CN105288190A - Anoectochilus roxburghii extract tablet and preparation method thereof - Google Patents
Anoectochilus roxburghii extract tablet and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an anoectochilus roxburghii extract tablet and a preparation method thereof. The preparation method comprises the following steps: placing dried anoectochilus roxburghii in a beaker, adding water to infiltrate anoectochilus roxburghii, heating and decocting anoectochilus roxburghii through a water bath; carrying out reduced-pressure suction filtration to obtain a water extract of anoectochilus roxburghii, performing reduced-pressure heating and concentration to obtain anoectochilus roxburghii extract; grinding xylitol by a high-speed pulverizer, sieving the powder by a No.7 officinal sieve; then adding anoectochilus roxburghii extract into the powder, fully kneading the components to obtain a soft material, wherein the soft material can be kneaded into a ball by hands and the balls can be broken up by light touch; sieving the soft material by a 24-mesh sieve through extrusion to prepare wet particles, evenly paving the particles on an enamel disc, placing the enamel disc in an electrothermal constant-temperature drying box to dry the particles; sieving the particles by a No.1 officinal sieve to remove the large particles, then sieving the particles by a No.6 officinal sieve to remove the fine powder; adding MS, filling the particles into bags, evenly mixing; adjusting the rotation speed and pressure, wherein the pressure is 26 to 30 Kn, and finally pressing the particles into tablets. The nutrients of five tablets of anoectochilus roxburghii extract are equal to that of one granule of dried anoectochilus roxburghii. The anoectochilus roxburghii extract tablet has a precise dosage, is easy to store and carry, and is user-friendly.
Description
Technical field
The present invention relates to field of traditional Chinese, particularly relate to a kind of Herba Anoectochili roxburghii extractum sheet and preparation method thereof.
Background technology
Herba Anoectochili roxburghii is orchid Anoectochilus Roxburghii Anoectochilusroxburghii (Wall) Lindl, another name Anoectochilus nefiliforme (Nakai) hara, Herba Melicae Scabrosae, have the laudatory title such as " king of medicine ", " gold grass ", " refreshing medicine ", " black Radix Ginseng ", " Fujian Province's prepared slices of Chinese crude drugs concocted specification version in 2012 " is recorded, Herba Anoectochili roxburghii has clearing away heat and cooling blood, expelling wind and removing dampness, removing toxic substances.Cure mainly cough due to lung-heat, spitting of blood, hematuria, acute infantile convulsion wind, jaundice, edema, stranguria, quenches one's thirst, rheumatic arthralgia, traumatic injury, venom.Modern for hepatitis, nephritis, cystitis, diabetes, bronchitis, the diseases such as rheumatic arthritis.Herba Anoectochili roxburghii is Fujian platform characteristic Chinese herbal medicine, the title have " king of medicine " among the people.
The generation of Chinese medical concrete tablet, not only to the improvement of the conventional dosage forms such as decoction, pill, is carry out processing the product extracting and make to Chinese crude drug.The dissolution of extract tablet and the more full powder tablet of bioavailability good; Except better than the dissolution of full powder tablet, extract tablet also maintains the advantage of full powder tablet: dosage is accurate, and in tablet, medicament contg difference is less; Steady quality; Take, carry, transport and storage etc. all more convenient; The mechanization degree of tablet is high, and output is large, and cost is low.At present, Chinese medicinal tablet has become wide in variety, output is large, purposes is wide, take and store and transport convenience, the main dosage form of stay-in-grade Chinese medicine.Compared to granule, both crude drugs all will be processed through extracting, but extract tablet can brew directly to be taken, and needs to brew convenient taking than granule.
In the market main with fresh Herba Anoectochili roxburghii, dry Herba Anoectochili roxburghii and Herba Anoectochili roxburghii tea in sale; Small part Herba Anoectochili roxburghii compound oral liquid and spray is had to cure the disease use to patient as hospital preparation in addition; Also have the instant powder of relevant Herba Anoectochili roxburghii, superfine powder, granule agent full powder tablet patent to solve Herba Anoectochili roxburghii to take, carry inconvenient problem, but hospital preparation only to be cured the disease use for patient in hospital, is not suitable for the daily health caring of ruck; And be no matter the instant powder of Herba Anoectochili roxburghii, superfine powder or the product of granule be all designed to the type that needs to brew with water, inconvenience is directly oral;
Summary of the invention
The object of the present invention is to provide a kind of dosage accurately, easily to store, carry simply and take the preparation method of Herba Anoectochili roxburghii extract tablet easily.
For achieving the above object, the invention provides a kind of preparation method of Herba Anoectochili roxburghii extractum sheet, it is characterized in that, step is,
Infiltrate and extract: get dry jewel orchid in beaker, after adding water infiltration, heating decocts; Decompress filter obtains the Aqueous extracts of Herba Anoectochili roxburghii;
Concentrated: Herba Anoectochili roxburghii Aqueous extracts heating under reduced pressure is concentrated to obtain Herba Anoectochili roxburghii extractum;
Soft material processed: get xylitol high speed disintegrator and pulverize, crosses No. 7 pharmacopeia sieves; Get the xylitol after sieving, add Herba Anoectochili roxburghii extractum, and said components is fully rubbed evenly, reach the soft material of " hands is pinched agglomerating, flicking and namely fallen apart ";
Granulation, drying: soft material is crossed 24 mesh sieves in the mode of extruding and makes wet granular, uniform spreading, on enamel tray, puts into Constant Temp. Oven, dry;
Granulate: screen out bulky grain by a pharmacopeia, then No. six pharmacopeia sieve sieves remove fine powder;
Tabletting: add MS, pack, mix homogeneously; Adjusting rotary speed and pressure tabletting.
Further, in described infiltration extraction step, the part by weight of dry jewel orchid and water is 1:(40-60); More than 80 DEG C decoct 60-90 minute; The wet weight of described dry jewel orchid is 6-12%.
Further, in described infiltration extraction step, the part by weight of dry jewel orchid and water is 1:40; 80 DEG C decoct 75 minutes.
Further, in described concentration step, heating-up temperature is 50-60 DEG C, and concentration time is 30-110 minute; Preferably 55 DEG C, concentration time is 70-110min; More preferably concentration time is 90 minutes.
Further, in described soft material step processed, the part by weight of Herba Anoectochili roxburghii extractum and xylitol is 60:(250-350); The part by weight of preferred Herba Anoectochili roxburghii extractum and xylitol is 60:(280-300).
Further, in described granulation, drying steps, baking temperature 45-55 DEG C, dry 1.7-3.6 hour.
Further, in described tableting step, add the hydrophobic lubricant MS of 1% weight.
Further, in described tableting step, rotary tablet machine pressure 26-30kN.
The Herba Anoectochili roxburghii extractum sheet that the present invention also provides the preparation method of described Herba Anoectochili roxburghii extractum sheet to prepare.
In tablet preparation, the object of granulation is not only mobility, dustability, adhesion in order to improve material and is conducive to accurate measurement, protection production environment etc., also must ensure the shape size of granule evenly, good looking appearance etc.Method of granulating has multiple.Method of granulating is different, even same prescription, it is also different for obtaining the shape of granulation thing, size, intensity, and disintegrative, dissolubility are also different, thus produces different drug effects.After Herba Anoectochili roxburghii extractum sheet adopts Herba Anoectochili roxburghii extractum and excipient elder generation Homogeneous phase mixing, then add adhesive and make its moistened surface, produce adhesion between powder, powder coalesces together thus prepares the method for granule.Therefore applicant of the present invention is through creationary research, obtain technical scheme of the present invention, adopt Herba Anoectochili roxburghii extractum to prepare tablet, and the nutritional labeling of Herba Anoectochili roxburghii is the highest, the tablet finally obtained is complete bright and clean, and without piebaldism, disintegration and tablet hardness meet the requirements.
The nutrition of the every 5 Herba Anoectochili roxburghii extract tablets of the present invention is equivalent to the nutrition of 1 dry jewel orchid.
Detailed description of the invention
Be described below in detail embodiments of the invention, the example of described embodiment is intended to for explaining the present invention, and can not be interpreted as limitation of the present invention.Unreceipted concrete technology or condition person in embodiment, according to the technology described by the document in this area or condition or carry out according to product description.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional products of commercial acquisition.
Embodiment: the preparation of Herba Anoectochili roxburghii extract tablet
Preparation process: infiltrate and extract: get dry jewel orchid in beaker, add water infiltration, through 1:10,1:20,1:40,1:60, the part by weight of 1:80, and ensure that the amount added water is advisable (if do not have submergence, Herba Anoectochili roxburghii can be cut off process, not have to make its submergence) with submergence Herba Anoectochili roxburghii, find that Herba Anoectochili roxburghii and water ratio are that the above effect of impregnation of 1:40 weight ratio is better, but the subsequent concentration process of 1:60,1:80 can extend the operating time, therefore Herba Anoectochili roxburghii and water ratio is adopted to be 1:40 weight ratio.Heating in water bath decocts (T=80 DEG C); Decompress filter obtains the Aqueous extracts of Herba Anoectochili roxburghii;
Concentrated: the heating of Herba Anoectochili roxburghii Aqueous extracts is condensed into extractum;
Soft material processed: get xylitol high speed disintegrator and pulverize, crosses No. 7 sieves; Get the xylitol after sieving, add concentration step gained extractum, said components is fully rubbed evenly, reach the soft material of " hands is pinched agglomerating, flicking and namely fallen apart ";
Granulation, drying: soft material is crossed pharmacopeia sieve series in the mode of extruding and becomes wet granular, uniform spreading, on enamel tray, puts into Constant Temp. Oven, dry;
Granulate: screen out bulky grain with a sieve, then No. six sieve sieves remove fine powder; Tabletting: add appropriate MS, pack, mix homogeneously; Adjusting rotary speed and pressure, tabletting.
1, best decoction temperature is determined, in table 1 according to total flavonoid glycoside content in Aqueous extracts.
The result of Anoectochilus roxburghii chemical composition pharmacological research shows, active polysaccharide wherein and total flavones are presumed to the main active of Herba Anoectochili roxburghii, flavone compound is rich in Herba Anoectochili roxburghii, main based on isorhamnetin, Quercetin and Rhizoma Kaempferiae phenolic flavonol glycosides, therefore flavones content is as an important indicator of Herba Anoectochili roxburghii quality control.
Table 1 difference decocts temperature to anoectochilus formosanus total flavonol glycosides content impact table
Inventor decocts temperature to Herba Anoectochili roxburghii and screens, decoct 60 minutes at decoction temperature is respectively 40 DEG C, 50 DEG C, 60 DEG C, 70 DEG C, 80 DEG C, 90 DEG C, 100 DEG C, detected total flavonoids content in the decoction liquor of different decoction temperature by chromatograph of liquid, filter out optimum extraction temperature.Total flavonoid alcohol glycoside is one of effective ingredient in Herba Anoectochili roxburghii, and mainly play antioxidation, anti-radical action, total flavonoid alcohol glycosides content is higher, illustrates that the active constituent content that it extracts is more from the side, and the effect of extraction is better.
Get each 32ml of decoction liquor that decocting time is respectively 40 DEG C, 50 DEG C, 60 DEG C, 70 DEG C, 80 DEG C, 90 DEG C, 100 DEG C, do the pre-treatment that high performance liquid chromatograph detects, in decoction liquor, add each 8ml of 36 volume % hydrochloric acid respectively obtain mixed liquor, mixed liquor refluxes 30 minutes (hydrochloric acid reflux adding 25 volume % makes flavone compound desaccharide) respectively at heating in water bath in 250ml round-bottomed flask, let cool to room temperature, be transferred to 50ml volumetric flask, adding distil water standardize solution, shake up, obtain test sample, parallel test three groups; And the concentration of each reference substance obtained is Quercetin 0.0318mg/ml, kaempferol 0.0309mg/ml, isorhamnetin 0.0221mg/ml.Accurate absorption reference substance solution and each 10 μ l of need testing solution respectively, injection liquid chromatography, measures, calculates the content of Quercetin, kaempferol and isorhamnetin respectively, be converted into the content of total flavonoids by following formula.
Total flavonoids content=(quercetin content+kaempferide content+isorhamnetin content) × 2.51.
Can be obtained by table 1, under decocting time is 60 minutes, decocting temperature is under 40 DEG C, 50 DEG C, 60 DEG C, 70 DEG C, 80 DEG C conditions, convert total flavonoids content is respectively 0.083%, 0.135%, 0.205%, 0.224%, 0.235%, the content of total flavonoids raises gradually with the rising decocting temperature, at decoction temperature 80 DEG C, 90 DEG C, 100 DEG C, total flavonoids content is 0.235%, and content no longer raises.Consider the saving energy, and other compositions of at utmost preserving capital Anoectochilus roxburghii are not at pyrolytic, the optimum temperature of decoction is more than 80 DEG C, preferably 80 DEG C.
2, according to the total flavonoids content determination optimum extraction time in decocting liquid.In table 2.
Table 2 hplc determination is total flavonoids table in 80 DEG C of different decoction duration decoction liquor
Get the decoction liquor that decocting time is respectively 30min, 45min, 60min, 75min, 90min, 105min, 120min, draw total flavonoids content by high performance liquid chromatograph measuring and calculating.
Can be found out by table 1 total flavonoid alcohol glycosides content, extraction time first time, the content of the total flavonoid alcohol glycosides in extracting solution raised gradually, is elevated to 0.254% by 0.143% from 30min to 75min, after 75min, content tends towards stability, and content is 0.254% to 0.255%.Therefore decocting time is selected effective at 60-90min, wherein 75min is best.
3, concentration technology experiment
The decoction liquor of above-mentioned 80 DEG C of decocting time 75min gained is placed in Rotary Evaporators concentrating under reduced pressure by applicant, is condensed into extractum, also explores concentration technology, in table 3,4 water-bath 55 DEG C.
Table 3 vacuum concentration equipment is at different temperatures to extracting solution concentrated effect table
| Extracting temperature/DEG C | Aqueous extracts state |
| 30 | Without boiling |
| 40 | Without boiling |
| 50 | Sometimes have and emit minute bubbles |
| 60 | Boiling |
| 70 | Bumping |
Extracting solution is poured in Rotary Evaporators by applicant, different bath temperature 30 DEG C, 40 DEG C, 50 DEG C, 60 DEG C, at 70 DEG C, extracting solution is concentrated, result is at 30 DEG C and 40 DEG C, extracting solution does not seethe with excitement, namely extracting solution does not reach boiling point, evaporation effect is not obvious, do not reach concentrated object, under 70 DEG C of bath temperatures, extracting solution bumping pours condensing unit, cannot effective Separation of Water steam, 50 DEG C and 60 DEG C of water-baths, extracting solution sometimes has and emits minute bubbles and boiling, illustrate that extracting solution reaches boiling point, start evaporation and concentration, therefore between the bath temperature optimal zone of vacuum concentration equipment between 50 DEG C-60 DEG C, therefore the intermediate value that applicant gets between optimal zone is tested again, at vacuum concentration equipment bath temperature 55 DEG C, extracting solution emits minute bubbles regularly, reach boiling point, therefore decompressor water-bath Wen Di is optimum temperature at 55 DEG C.
Table 4 different concentration time extractum density contrast table
| Concentration time/min | Extractum density ml/g |
| 30 | 0.98 |
| 50 | 1.00 |
| 70 | 1.01 |
| 90 | 1.08 |
| 110 | 1.12 |
| 130 | 1.13 |
| 150 | 1.15 |
| 170 | 1.16 |
Decoction liquor is poured on vacuum concentration equipment by applicant, 55 DEG C of concentrating under reduced pressure, the density of concentrated solution is measured respectively at 30min, 50min, 70min, 90min, 110min, 130min, 150min, 170min, be respectively 0.98ml/g, 1.00ml/g, 1.01ml/g, 1.02ml/g, 1.04ml/g, 1.05ml/g, 1.08ml/g, 1.09ml/g, can find out, along with the increase of concentration time, decoction liquor volume reduces, and density increases gradually.Extractum concentration is low, concentrated solution not only in every ml soln the active constituent content of Herba Anoectochili roxburghii lower, in the tablet made, active constituent content is also low, dose is large, therefore the density of extractum is higher, in the tablet made, the active constituent content of Herba Anoectochili roxburghii is higher, and dose is less.But extractum concentration is too high, then can too thickness, be unfavorable for toppling over.Extractum too thickness after this experiment is concentrated after 130min, is unfavorable for toppling over.Therefore, the preferred concentration time of the present invention is 70-110min, and best preferred concentration time is 90min, and its extractum concentration is proper.
3, granulation drying process experiment
When preparing granular preparation, applicant has carried out a large amount of groping, in table 5 and table 6 to the xylitol after sieving and the weight ratio of the concentration step gained extractum added.
The different extractum of table 5 and xylitol ratio make the effect table (1) of soft material
| Extractum, xylitol ratio (g) | Soft material effect |
| 60:200 | Soft material is excessively soft, excessively glutinous, and hands is pinched agglomerating, and flicking does not fall apart |
| 60:250 | Soft material is partially soft, and hands is pinched agglomerating, and that presses then falls apart |
| 60:300 | Soft material hands is pinched agglomerating, and namely flicking falls apart |
| 60:350 | Soft material is partially dry, and hands is pinched agglomerating, and namely flicking falls apart |
| 60:400 | Soft material is too dry, and viscosity is not enough, and hands is pinched more difficult agglomerating and with fine powder |
Applicant makes soft material by a certain percentage by Herba Anoectochili roxburghii concentrated extract (density is 1.08ml/g) and xylitol, screens soft material Contrast on effect example.
Herba Anoectochili roxburghii extractum and xylitol weight (g) are respectively 60:200, when 60:250,60:300,60:350,60:400, are mixed in proportion making soft material, and wherein the soft material made of 60:200 ratio is excessively soft, excessively glutinous; The soft material that 60:400 makes is partially dry, and viscosity is not enough, and with fine powder, the soft material poor effect that above two kinds of ratios are made, with 60:250,60:300, the soft material effect that 60:350 ratio is made is better, therefore segments in 60:250 to 60:350 interval, table 4 between result of the test again.
The different extractum of table 6 and xylitol ratio make the effect table (2) of soft material
| Extractum, xylitol ratio (g) | Soft material effect |
| 60:260 | Soft material is partially soft, and hands is pinched agglomerating, and that presses then falls apart |
| 60:280 | Soft material hands is pinched agglomerating, and namely flicking falls apart |
| 60:300 | Soft material hands is pinched agglomerating, and namely flicking falls apart |
| 60:320 | Soft material hands is pinched agglomerating, and namely flicking falls apart, with micro-fine powder |
| 60:340 | Soft material is partially dry, and hands is pinched agglomerating, and namely flicking falls apart, with a small amount of fine powder |
As can be seen from Table 6, contrast the soft material effect made, the soft material that extractum, xylitol part by weight 60:260 make is partially soft.And the soft material that 60:320 and 60:340 ratio is made is partially dry, stickiness is slightly not enough, less effective, the soft material made with 60:280 and 60:300 is held agglomerating, and namely flicking falls apart, best results.
Applicant has also carried out a series of exploration to the baking temperature in drying and granulating process and time, refers to table 7.
Table 7: different dry temperature and time affects table to result
As known from Table 7, the present invention selects 45-55 DEG C, and 1.7-3.6h carries out drying, dried particle drying, color and luster can be made consistent, lump on a small quantity, without deliquescence.
Dry granulation, applicant has also carried out probing in a large number, in table 8 to tablet appearance, disintegration and hardness under tablet machine different pressures.
The different tablet machine pressure of table 8 on tablet appearance, disintegration, hardness affect table
Applicant checks tablet appearance, and draw samples 20 is laid on white background plate, is placed in 60cm place under 75W light source, and sentencing perusal 30 seconds at distance tablet 30cm, check that whether complete tablet is bright and clean, uniform color, with or without serious piebaldism or foreign body.First under tablet machine 20Kn, 22Kn pressure, due to insufficient pressure, tablet portion is loose imperfect, and under 24-32Kn pressure, tablet is complete bright and clean, without piebaldism;
Applicant probes into the disintegration of tablet time limit again, first lift disintegration tester is checked, hanging basket is hung on metal rack by the stainless steel shaft of upper end, immerses in 1000ml beaker, in cup, fill the thermostatted water that temperature is 37 DEG C ± 1 DEG C, when regulating height of water level to be hanging basket rising, screen cloth is at 15mm place, underwater, and during decline, screen cloth is apart from beaker bottom 25mm, support moves up and down distance for 55mm ± 2mm, and roundtrip frequency is 30-32 time per minute.The former powder sheet of depletion Anoectochilus roxburghii 6, is placed in the glass tubing of hanging basket, often manages and add 1, add baffle plate, starts disintegration tester and checks, calculate the meansigma methods of 6 disintegrations.Result is under 20Kn, 22kN, 24Kn, 26Kn, 28Kn, 30Kn pressure, the disintegration of tablet is respectively 4min, 7min, 18min, 22min, 24min, 26min, and under 32Kn pressure, disintegration is 38min, long (" Chinese Pharmacopoeia " 2015 editions four 0921 regulations of disintegration time, each of Chinese medicine full powder sheet all should whole disintegrate in 30min), thus the disintegration of tablet time limit of making under 20-30Kn pressure meet the requirements.
The inspection of tablet hardness, with Meng Shan all durometers, stands between two pressing plates by tablet, the pressurization slowly along tablet diameters direction, until broken, measure and makes broken required power.Wherein under 20Kn, 22kN, 24Kn pressure, tablet hardness is respectively 1.7Kg, 1.8Kg, 1.8Kg, hardness is less than normal, easily break up in transportation, the integrity of tablet can not be ensured, general Chinese medicinal tablet hardness is at 2-3Kg: under 26Kn, 28Kn, 30Kn, 32Kn pressure, tablet hardness is respectively 2.3Kg, 2.6Kg, 2.9Kg, 3.2Kg, and hardness meets the requirements.
In sum, tablet machine is best under 26-30Kn pressure, and tablet is complete bright and clean, and without piebaldism, disintegration and tablet hardness meet the requirements.
4, tablet dose inspection
The active constituent content of tablet is stablized, relevant with tablet weight, only has tablet weight variation at bottom line, and the every sheet of guarantee, containing the stable effective ingredients of Herba Anoectochili roxburghii, guarantees that taking dose is accurate.
Technological parameter is: dry Herba Anoectochili roxburghii: water is 1:40 weight ratio, and 80 DEG C decoct 75 minutes, and 55 DEG C of concentrating under reduced pressure 90 minutes, concentrated extract and xylosic alcohol powder are that 60:300 weight ratio makes soft material, and wet granular, 45 DEG C of dryings 3.6 hours, becomes tablet at 28Kn pressure.
Applicant does tablet weight variation inspection, because in tablet manufacture, some factor is as the uniformity of granule and flow velocity, and the uniformity of lubricant etc. all can cause tablet weight variation.Weight differential is large, then affect the content of main Herba Anoectochili roxburghii effective ingredient in sheet, therefore the weight differential of tablet must be controlled in bottom line.
Inspection method is as follows: the tablet made under doing 2 batches of same process parameters, often criticize depletion Anoectochilus roxburghii extract tablet 20, accurately weighed gross weight, after trying to achieve average sheet weight, in the weight of accurately weighed each of difference, every sheet weight, compared with average weight, specifies according to " Chinese Pharmacopoeia ", the medicine exceeding limits of error angle value (± 0.05 gram) more than 2, and must not must not have one times of 1 overrun.Data are in table 9;
Table 9 tablet weight variation table
Note: wherein the limit of error is the value that every sheet weight deducts the average weight of 20, the meansigma methods of the limit of error is after 20 limits of error angle value ask absolute value, summation, then tries to achieve weighted mean.
As can be seen from Table 9, according to the tablet that the preparation technology parameter of Herba Anoectochili roxburghii extractum is made, random choose 20, accurately weighed, first average weight is 0.333759 gram, the limit of error weighted mean of weight is 0.00474 gram, and does not have a slice to exceed limits of error angle value (0.05 gram); First average weight is 0.33532 gram, and the limit of error weighted mean of weight is 0.00263 gram, and does not have a slice to exceed limits of error angle value (0.05 gram).So the weight differential of tablet conforms with the regulations.
Although illustrate and describe embodiments of the invention above, be understandable that, above-described embodiment is exemplary, can not be interpreted as limitation of the present invention, those of ordinary skill in the art can change above-described embodiment within the scope of the invention when not departing from principle of the present invention and aim, revising, replacing and modification.
Claims (9)
1. a preparation method for Herba Anoectochili roxburghii extractum sheet, is characterized in that, step is,
Infiltrate and extract: get dry jewel orchid in beaker, after adding water infiltration, heating decocts; Decompress filter obtains the Aqueous extracts of Herba Anoectochili roxburghii;
Concentrated: Herba Anoectochili roxburghii Aqueous extracts heating under reduced pressure is concentrated to obtain Herba Anoectochili roxburghii extractum;
Soft material processed: get xylitol high speed disintegrator and pulverize, crosses No. 7 pharmacopeia sieves; Get the xylitol after sieving, add Herba Anoectochili roxburghii extractum, and said components is fully rubbed evenly, reach the soft material of " hands is pinched agglomerating, flicking and namely fallen apart ";
Granulation, drying: soft material is crossed 24 mesh sieves in the mode of extruding and makes wet granular, uniform spreading, on enamel tray, puts into Constant Temp. Oven, dry;
Granulate: screen out bulky grain by a pharmacopeia, then No. six pharmacopeia sieve sieves remove fine powder;
Tabletting: add MS, pack, mix homogeneously; Adjusting rotary speed and pressure tabletting.
2. the preparation method of Herba Anoectochili roxburghii extractum sheet described in claim 1, is characterized in that, in described infiltration extraction step, the part by weight of dry jewel orchid and water is 1:(40-60); More than 80 DEG C decoct 60-90 minute; The wet weight of described dry jewel orchid is 6-12%.
3. the preparation method of Herba Anoectochili roxburghii extract tablet described in claim 1, is characterized in that, in described infiltration extraction step, the part by weight of dry jewel orchid and water is 1:40; 80 DEG C decoct 75 minutes.
4. the preparation method of Herba Anoectochili roxburghii extractum sheet described in claim 1, is characterized in that, in described concentration step, heating-up temperature is 50-60 DEG C, and concentration time is 30-110 minute; Preferably 55 DEG C, concentration time is 70-110min; More preferably concentration time is 90 minutes.
5. the preparation method of Herba Anoectochili roxburghii extractum sheet described in claim 1, is characterized in that, in described soft material step processed, the part by weight of Herba Anoectochili roxburghii extractum and xylitol is 60:(250-350); The part by weight of preferred Herba Anoectochili roxburghii extractum and xylitol is 60:(280-300).
6. the preparation method of Herba Anoectochili roxburghii extractum sheet described in claim 1, is characterized in that, in described granulation, drying steps, and baking temperature 45-55 DEG C, dry 1.7-3.6 hour.
7. the preparation method of Herba Anoectochili roxburghii extractum sheet described in claim 1, is characterized in that, in described tableting step, adds the hydrophobic lubricant MS of 1% weight.
8. the preparation method of Herba Anoectochili roxburghii extractum sheet described in claim 1, is characterized in that, in described tableting step, and rotary tablet machine pressure 26-30kN.
9. the Herba Anoectochili roxburghii extractum sheet for preparing of the preparation method of Herba Anoectochili roxburghii extractum sheet described in any one of claim 1-8.
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Cited By (2)
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| CN105685997A (en) * | 2016-02-23 | 2016-06-22 | 康连飞 | Diet therapy product for resisting cell senescence and promoting cell regeneration and method for preparing diet therapy product |
| CN115644286A (en) * | 2022-08-30 | 2023-01-31 | 中国农业科学院茶叶研究所 | Anoectochilus roxburghii health-preserving tea tablet and preparation method thereof |
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| CN105685997B (en) * | 2016-02-23 | 2018-11-13 | 康连飞 | A kind of anti-cell aging and the dietary product and preparation method thereof for promoting cytothesis |
| CN115644286A (en) * | 2022-08-30 | 2023-01-31 | 中国农业科学院茶叶研究所 | Anoectochilus roxburghii health-preserving tea tablet and preparation method thereof |
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