CN101703753B

CN101703753B - Medicinal composition powders or granules for treating whitevein and preparation method thereof

Info

Publication number: CN101703753B
Application number: CN2009102112602A
Authority: CN
Inventors: 张樱山; 陈丽娟; 张国霞; 李波
Original assignee: Gansu Qizheng Tibetan Medicine Co Ltd
Current assignee: Gansu Qizheng Tibetan Medicine Co Ltd
Priority date: 2009-11-05
Filing date: 2009-11-05
Publication date: 2011-08-17
Anticipated expiration: 2029-11-05
Also published as: CN101703753A

Abstract

The invention discloses a medicinal composition powders or granules for treating whitevein and a preparation method thereof. The powders or granules are prepared by taking a formula of conventional Tibetan medicament white-plus unguent as a basic formula and modifying the formulation. In the invention, an adopted preparation method of extracting some medicinal materials and making other medicinal materials into superfine powder effectively retains the active ingredients in the medicinal materials, greatly improves the raw medicament component content and improves bioavailability, so that the curative effect of the gel is better. The powders or granules of the invention adopt a medicated bath therapy which is favorable for the absorption of medicaments and increases the effect of a medicament therapy. The method for preparing the medicinal composition powders or granules is easy and feasible, and is easy for industrialization.

Description

A kind of medicinal composition powders for the treatment of aortic arch syndrome or granule and preparation method thereof

Invention field

The present invention relates to a kind of medicinal composition powders or granule and preparation method thereof, particularly a kind of medicinal composition powders for the treatment of aortic arch syndrome or granule and preparation method thereof.

Background technology

The lung-pulse ointment is that the doctor among the people of Tibetan is carried according to " Tibetan medicine doctor certainly addendum releases difficulty ", the Four-Volume Medical Code two secretaries, in conjunction with the classical Tibetan medicine and pharmacology proved recipe that practical experience is formed, the lung-pulse ointment is former to be recorded in first 310 pages of " health drug standard promulgated by the ministries or commissions of the Central Government " 95 years version Tibetan medicines.The prescription of the lung-pulse ointment is:

Rhizoma Curcumae Longae 150g, Semen Myristicae 50g, Radix Et Rhizoma Nardostachyos 80g, Actinolitum 50g, Radix Glycyrrhizae 70g, artificial Moschus or Moschus 0.7g, Rhizoma Kaempferiae 100g, Fructus cari carvi 130g, Rhizoma Acori Calami 70g, Pericarpium Zanthoxyli 50g, trona 75g.

Method for making: above ten simply, and except that artificial Moschus or other porphyrize powder of Moschus, all the other are ground into fine powder altogether, sieve, and add artificial Moschus or Moschus fine powder facing-up, with butter and Adeps Sus domestica furnishing ointment, promptly.

Function with cure mainly: relaxing muscles and tendons and activating QI and blood in the collateral.Be used for aortic arch syndrome, paralysis, hemiplegia, the muscle tendon is tetanic, meridians that wound causes and muscle tendon break wound, brothers' contraction urgency, limping etc.

According to Tibetan medicine's theory, disorders of meridian is divided into the lung-pulse and Hei Mai, wherein the lung-pulse is the venation that human body at first bears at embryo stage, it also is the venation that fetal development obtains nutrition, these venations of birth back play again and absorb diet elite, conveying waste matter, to guarantee the normal circulation of three factors, seven materials,, can cause the generation of various diseases if the function of these venations gets muddled.The main pathogenic factor of aortic arch syndrome has following three aspects: aggravating activities, damage body venation; Pestilent toxicity pathogenic heat etc. is fallen in the arteries and veins; Mechanical damages such as weapons club cause rheumatism; In disorder and go into sering.The Tibetan medicine is the vital energy regualting and blood circulation-promoting collateral dredging to the regulation principle of aortic arch syndrome.Tibetan people is according to the Four-Volume Medical Code, " brilliant pearl book on Chinese herbal medicine " record, in conjunction with long-term practical experience, with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Moschus, Fructus cari carvi, Pericarpium Zanthoxyli, trona is the Tibetan medicine the lung-pulse ointment of raw material production, be subjected to the trust of extensive patients with significant mass effect, but traditional Tibetan medicine the lung-pulse ointment preparation technology is modulated into ointment after all crude drug fine powders are mixed, its technology is numerous and diverse, and batch production cycle is long, the production technology instability; Raw material and adjuvant source are unstable, are unfavorable for suitability for industrialized production; Part drug osmotic ability, bioavailability is low, can not guarantee curative effect fully, should not bring into play the curative effect of medicine; Product should not be deposited in addition, carries inconvenience; Because each side has greatly influenced the curative effect and the popularization of product.

Summary of the invention

It is medicinal composition powders or the granule that basic square tube is crossed the treatment aortic arch syndrome that dosage changing form prepares that the object of the invention is to disclose a kind of prescription with traditional Tibetan medicine the lung-pulse ointment, and the object of the invention also is to disclose the preparation method of this powder or granule.

The present invention seeks to be achieved through the following technical solutions.

The crude drug of powder of the present invention or granule is formed and consumption is:

Rhizoma Curcumae Longae 30-40 weight portion, Semen Myristicae 10-15 weight portion, Radix Et Rhizoma Nardostachyos 15-25 weight portion, Actinolitum 10-15 weight portion, Radix Glycyrrhizae 15-20 weight portion, artificial Moschus or Moschus 0.15-0.2 weight portion, Rhizoma Zingiberis 20-28 weight portion, Fructus cari carvi 28-35 weight portion, Rhizoma Acori Calami 15-20 weight portion, Pericarpium Zanthoxyli 10-15 weight portion, trona 15-20 weight portion.

The crude drug of powder of the present invention or granule is formed and consumption is preferably:

Rhizoma Curcumae Longae 36.3 weight portions, Semen Myristicae 12.1 weight portions, Radix Et Rhizoma Nardostachyos 19.4 weight portions, Actinolitum 12.1 weight portions, Radix Glycyrrhizae 17.0 weight portions, artificial Moschus or Moschus 0.17 weight portion, Rhizoma Zingiberis 24.2 weight portions, Fructus cari carvi 31.5 weight portions, Rhizoma Acori Calami 17.0 weight portions, Pericarpium Zanthoxyli 12.1 weight portions, trona 18.2 weight portions.

The adjuvant of powder of the present invention and consumption are:

Antibacterial: one or more in methyl hydroxybenzoate 0-10 weight portion, ethyl hydroxybenzoate 0-10 weight portion, butoben 0-10 weight portion and the sodium benzoate 0-10 weight portion.

The adjuvant and the consumption of powder of the present invention are preferably:

Antibacterial: one or more in methyl hydroxybenzoate 2-8 weight portion, ethyl hydroxybenzoate 2-8 weight portion, butoben 2-8 weight portion and the sodium benzoate 2-8 weight portion.

Antibacterial: one or more in methyl hydroxybenzoate 5 weight portions, ethyl hydroxybenzoate 5 weight portions, butoben 5 weight portions and sodium benzoate 5 weight portions;

Or antibacterial: one or more in methyl hydroxybenzoate 1 weight portion, ethyl hydroxybenzoate 9 weight portions, butoben 9 weight portions and sodium benzoate 1 weight portion;

Or antibacterial: one or more in methyl hydroxybenzoate 9 weight portions, ethyl hydroxybenzoate 1 weight portion, butoben 1 weight portion and sodium benzoate 9 weight portions.

The adjuvant of granule of the present invention is formed and consumption is:

Lactose 0-2000 weight portion, dextrin 0-500 weight portion, polyvinylpyrrolidone 0-500 weight portion, carboxymethyl starch sodium 0-1000 weight portion and antibacterial; Wherein antibacterial is one or more in methyl hydroxybenzoate 0-10 weight portion, ethyl hydroxybenzoate 0-10 weight portion, butoben 0-10 weight portion and the sodium benzoate 0-10 weight portion.

The adjuvant and the consumption of granule of the present invention are preferably:

Lactose 50-1500 weight portion, dextrin 50-450 weight portion, polyvinylpyrrolidone 50-450 weight portion, carboxymethyl starch sodium 50-800 weight portion and antibacterial; Wherein antibacterial is one or more in methyl hydroxybenzoate 2-8 weight portion, ethyl hydroxybenzoate 2-8 weight portion, butoben 2-8 weight portion and the sodium benzoate 2-8 weight portion.

Lactose 1000 weight portions, dextrin 250 weight portions, polyvinylpyrrolidone 250 weight portions, carboxymethyl starch sodium 400 weight portions and antibacterial; Wherein antibacterial is one or more in methyl hydroxybenzoate 5 weight portions, ethyl hydroxybenzoate 5 weight portions, butoben 5 weight portions and sodium benzoate 5 weight portions;

Or lactose 1200 weight portion dextrin 300 weight account polyethylene ketopyrrolidines 300 weight portion carboxymethyl starch sodium 600 weight portions;

Or lactose 1900 weight portion dextrin 10 weight account polyethylene ketopyrrolidines 490 weight portion carboxymethyl starch sodium 10 weight portions;

Or lactose 10 weight portion dextrin 490 weight account polyethylene ketopyrrolidines 10 weight portion carboxymethyl starch sodium 990 weight portions;

Or lactose 67 weight portion dextrin 16.5 weight account polyethylene ketopyrrolidines 16.5 weight portion carboxymethyl starch sodium 33.5 weight portions;

Or lactose 88 weight portion dextrin 22 weight account polyethylene ketopyrrolidines 22 weight portion carboxymethyl starch sodium 44 weight portions, ethyl hydroxybenzoate 5.0 weight portions;

Or lactose 400 weight portion dextrin 100 weight account polyethylene ketopyrrolidines 100 weight portion carboxymethyl starch sodium 200 weight portions;

Or lactose 415 weight portion dextrin 104 weight account polyethylene ketopyrrolidines 104 weight portion carboxymethyl starch sodium 207.5 weight portions, sodium benzoate 3.5 weight portions;

Or lactose 100 weight portion dextrin 25 weight account polyethylene ketopyrrolidines 25 weight portion carboxymethyl starch sodium 50 weight portions, butoben 5.0 weight portions;

Or lactose 1938 weight portion dextrin 484.5 weight account polyethylene ketopyrrolidines 484.5 weight portion carboxymethyl starch sodium 969 weight portions;

Or lactose 100 weight portion dextrin 25 weight account polyethylene ketopyrrolidines 25 weight portion carboxymethyl starch sodium 50 weight portions;

Or lactose 160 weight portion dextrin 40 weight account polyethylene ketopyrrolidines 40 weight portion carboxymethyl starch sodium 80 weight portions, methyl hydroxybenzoate 6.5 weight portions;

Or lactose 168 weight portion dextrin 42 weight account polyethylene ketopyrrolidines 42 weight portion carboxymethyl starch sodium 84 weight portions;

Or lactose 144 weight portion dextrin 36 weight account polyethylene ketopyrrolidines 36 weight portion carboxymethyl starch sodium 72 weight portions.

The preparation method of powder of the present invention or granule comprises a kind of in A and the B method:

The A method:

1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are carried out remove impurity, cleaning, drying respectively, be ground into the medicated powder that particle diameter is 0.1-150 μ m;

2. artificial Moschus or Moschus are ground to form fine powder;

3. the medicated powder mix homogeneously that makes in 1. of artificial Moschus that 2. step is obtained or Moschus fine powder and above-mentioned steps or add antibacterial is again made powder of the present invention;

Medicated powder and adjuvant mix homogeneously that artificial Moschus that 2. step is obtained or Moschus fine powder and above-mentioned steps make in are 1. made granule of the present invention;

The B method:

1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona remove impurity, clean system, mixing;

2. artificial Moschus or Moschus are ground to form fine powder;

3. take by weighing the 10%-100% of above-mentioned mixed material medicine total amount, boil 1-4 time with 5-20 times of weight decocting, the each decoction 0.5-3 hour, collection, merge extractive liquid, and volatile oil, it is the concentrated solution of 1.0-1.5 that filtration and concentrated extracting solution become relative density, and volatile oil joined in the concentrated solution, concentrated solution a;

Or take by weighing the 10%-100% of above-mentioned mixed material medicine total amount, and with the 30-90% ethanol extraction of 5-20 times of weight 1-4 time, extracted 0.5-24 hour at every turn, collect extracting solution, filtration, being condensed into relative density is the concentrated solution a of 1.0-1.5;

4. will remain hybrid medicine and be ground into medicated powder and above-mentioned concentrated solution a, artificial Moschus or the Moschus fine powder mix homogeneously that particle diameter is 0.1-150 μ m, or add antibacterial again, make powder of the present invention;

The residue hybrid medicine is ground into medicated powder and above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder and the adjuvant mix homogeneously that particle diameter is 0.1-150 μ m, makes granule of the present invention.

The preparation method of powder of the present invention or granule preferably includes a kind of in A and the B method:

The A method:

1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are carried out remove impurity, cleaning, drying respectively, be ground into the superfine powder that particle diameter is 0.1-1 μ m;

2. artificial Moschus or Moschus are ground to form fine powder;

3. the superfine powder mix homogeneously that makes in 1. of artificial Moschus that 2. step is obtained or Moschus fine powder and above-mentioned steps or add antibacterial is again made powder of the present invention;

Superfine powder and adjuvant mix homogeneously that artificial Moschus that 2. step is obtained or Moschus fine powder and above-mentioned steps make in are 1. made granule of the present invention;

The B method:

1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and trona remove impurity, clean system is mixed;

2. take by weighing 10% of above-mentioned mixed material medicine total amount, boil 4 times, decocted 3 hours at every turn with 5 times of weight decoctings, collection, merge extractive liquid, and volatile oil, it is the concentrated solution of 1.25-1.35 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Or take by weighing 10% of above-mentioned mixed material medicine total amount, and with 30% ethanol extraction of 5 times of weight 4 times, extracted 3 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.25-1.35;

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into superfine powder and above-mentioned concentrated solution a, artificial Moschus or the Moschus fine powder mix homogeneously that particle diameter is 0.1-1 μ m, or add antibacterial again, make powder of the present invention;

The residue hybrid medicine is ground into superfine powder and above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder and the adjuvant mix homogeneously that particle diameter is 0.1-1 μ m, makes granule of the present invention.

The A method:

1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are carried out remove impurity, cleaning, drying respectively, be ground into the superfine powder that particle diameter is 1-10 μ m;

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

2. take by weighing 20% of above-mentioned mixed material medicine total amount, boil 3 times, decocted 1 hour at every turn with 15 times of weight decoctings, collection, merge extractive liquid, and volatile oil, it is the concentrated solution of 1.35-1.45 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Or take by weighing 20% of above-mentioned mixed material medicine total amount, and with 40% ethanol extraction of 15 times of weight 3 times, extracted 1 hour at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.35-1.45;

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into superfine powder and above-mentioned concentrated solution a, artificial Moschus or the Moschus fine powder mix homogeneously that particle diameter is 1-10 μ m, or add antibacterial again, make powder of the present invention;

The residue hybrid medicine is ground into superfine powder and above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder and the adjuvant mix homogeneously that particle diameter is 1-10 μ m, makes granule of the present invention.

The A method:

1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are carried out remove impurity, cleaning, drying respectively, be ground into the superfine powder that particle diameter is 10-40 μ m;

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

2. take by weighing 50% of above-mentioned mixed material medicine total amount, boil 1 time, decocted 1.5 hours at every turn with 20 times of weight decoctings, collection, merge extractive liquid, and volatile oil, it is the concentrated solution of 1.15-1.25 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Or take by weighing 50% of above-mentioned mixed material medicine total amount, and with 50% ethanol extraction of 20 times of weight 1 time, extracted 1.5 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.15-1.25;

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into superfine powder and above-mentioned concentrated solution a, artificial Moschus or the Moschus fine powder mix homogeneously that particle diameter is 10-40 μ m, or add antibacterial again, make powder of the present invention;

The residue hybrid medicine is ground into superfine powder and above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder and the adjuvant mix homogeneously that particle diameter is 10-40 μ m, makes granule of the present invention.

The A method:

1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are carried out remove impurity, cleaning, drying respectively, be ground into the medicated powder that particle diameter is 40-60 μ m;

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

2. take by weighing 60% of above-mentioned mixed material medicine total amount, boil 2 times, decocted 2.5 hours at every turn with 10 times of weight decoctings, collection, merge extractive liquid, and volatile oil, it is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Or take by weighing 60% of above-mentioned mixed material medicine total amount, and with 80% ethanol extraction of 10 times of weight 2 times, extracted 20 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.05-1.15;

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into medicated powder and above-mentioned concentrated solution a, artificial Moschus or the Moschus fine powder mix homogeneously that particle diameter is 40-60 μ m, or add antibacterial again, make powder of the present invention;

The residue hybrid medicine is ground into medicated powder and above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder and the adjuvant mix homogeneously that particle diameter is 40-60 μ m, makes granule of the present invention.

The A method:

1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are carried out remove impurity, cleaning, drying respectively, be ground into the medicated powder that particle diameter is 60-90 μ m;

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

2. take by weighing 90% of above-mentioned mixed material medicine total amount, boil 2 times, decocted 2.5 hours at every turn with 10 times of weight decoctings, collection, merge extractive liquid, and volatile oil, it is the concentrated solution of 1.15-1.25 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Or take by weighing 90% of above-mentioned mixed material medicine total amount, and with 90% ethanol extraction of 10 times of weight 1 time, extracted 24 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.15-1.25;

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into medicated powder and above-mentioned concentrated solution a, artificial Moschus or the Moschus fine powder mix homogeneously that particle diameter is 60-90 μ m, or add antibacterial again, make powder of the present invention;

The residue hybrid medicine is ground into medicated powder and above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder and the adjuvant mix homogeneously that particle diameter is 60-90 μ m, makes granule of the present invention.

The A method:

1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are carried out remove impurity, cleaning, drying respectively, be ground into the medicated powder that particle diameter is 90-150 μ m;

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

2. take by weighing above-mentioned mixed material medicine, boil 3 times, decocted 2 hours at every turn with 10 times of weight decoctings, collection, merge extractive liquid, and volatile oil, it is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Or take by weighing above-mentioned mixed material medicine, and use 60% ethanol extraction 3 times of 10,8,6 times of medicine gross weights respectively, extracted respectively 90,60,30 minutes at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.05-1.15;

3. artificial Moschus or Moschus are ground to form fine powder;

4. with above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder mix homogeneously, or add antibacterial again, make powder of the present invention;

With above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder and adjuvant mix homogeneously, make granule of the present invention.

Powder of the present invention or granule are compared with prior art the lung-pulse ointment has following characteristics:

1, powder of the present invention or granule adopt the dipping treatment, help the absorption of medicine, and increase the effect of Drug therapy.

2, preparation method of the present invention is simple, is easy to industrialization.

3, the present invention adopts the preparation method of part medicinal material extract part medical material micronizing, has both kept effective ingredient in the medical material effectively, has improved the content of crude drug composition again greatly, has improved bioavailability and stripping, makes curative effect better.

Following experimental example and embodiment are used to further specify but are not limited to the present invention.

The adjuvant screening experiment of experimental example 1 granule of the present invention

1. the screening experiment of single adjuvant

According to bibliographical information and practical experience, determine the kind of the single adjuvant of screening, experimental design sees Table 1.

The screening of the single adjuvant of table 1

Take by weighing Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g, earlier the artificial Moschus is ground to form fine powder; All the other medical materials 10 times of water of medicine gross weight, decoct 2 times, the each decoction 2.5 hours, collection, merge extractive liquid, and volatile oil, it is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density, and volatile oil joined in the concentrated solution, add the artificial Moschus and grind to form fine powder, stir.Get 9 parts of concentrated solutions, every part of 50g tests by table 1 scheme, adds each 50g of listed corresponding auxiliary material in the table in medicinal liquid, mixing, with 75% ethanol system soft material, cross 14 mesh sieves and granulate 60 ℃ of oven dry, cross No. 1 sieve and No. 4 sieves successively, collect by No. 1 sieve and can not weigh, calculate ratio of briquetting by the granule of No. 4 sieves; Get the about 2.0g of above-mentioned each sample particle, after 60 ℃ of constant weights, accurate claim surely, placing relative humidity is 75% close drying device, and room temperature is placed, and measures once its hygroscopicity every 8h, to the granule jog full moisture absorption caking that do not clear.Measure ratio of briquetting and moisture absorption percentage rate, the results are shown in Table 2.

Single adjuvant ratio of briquetting of table 2 and the percentile measurement result of moisture absorption

Ratio of briquetting (%)=can not weigh * 100% by No. 4 sieve granule weight/sample particles by No. 1 sieve

Weight * 100% before moisture absorption percentage rate (%)=(the preceding weight of weight-moisture absorption after the moisture absorption)/moisture absorption

The ratio of briquetting and the moisture absorption percentage rate of the sample particle that different auxiliary material is made carry out comprehensive grading, total points 100 minutes, and wherein, ratio of briquetting accounted for 30 fens, and hydroscopicity accounted for 70 fens, determined best single adjuvant, the results are shown in Table 3.

The single adjuvant screening of table 3 comprehensive grading

Conclusion: No. 1 sample concentration liquid is directly granulated, and from observing in appearance, its hygroscopicity is stronger, and is less than 30min being the moisture absorption caking, therefore, minimum in comprehensive grading.With starch and mannitol is that adjuvant is granulated, and ratio of briquetting is low slightly, but its moisture absorption percentage rate is higher, and promptly part is lumpd behind 30min, thereby causes comprehensive grading on the low side; And lactose and dextrin be as the grain forming rate height of adjuvant, and hygroscopicity is little, meets the prescription of granule adjuvant; Carboxymethyl starch sodium is compared with microcrystalline Cellulose, ratio of briquetting height and hygroscopicity is little, polyvinylpyrrolidone is compared with 50% ethanol, and its ratio of briquetting height and hygroscopicity is little is so the present invention selects lactose, dextrin, carboxymethyl starch sodium and the polyvinylpyrrolidone adjuvant as pharmaceutical composition of the present invention.

2. the screening experiment of mixed accessories

According to single adjuvant The selection result, with lactose, dextrin, carboxymethyl starch sodium, polyvinylpyrrolidone is that mixed accessories screens its proportioning, adopt orthogonal experiment, with curcumin content serves as to investigate index, select lactose, dextrin, carboxymethyl starch sodium, polyvinylpyrrolidone as the investigation factor, adopt L ₉(3 ⁴) Orthogonal Experiment and Design tests, the factor level arrangement sees Table 4.

Table 4 factor level table

With concentrated solution 50g is 1 part, presses orthogonal test table 4 schemes and adds ormal weight proportioning adjuvant, mixing, prepare the granule method as single adjuvant and be prepared into granule, get the granule 2.0g under the orthogonal test item, the accurate title, decide, and puts in the tool plug conical flask, the accurate methanol 10ml that adds, claim to decide weight, reflux 30min is put cold, claim to decide weight again, supply the weight that subtracts mistake with methanol, shake up, centrifugal, precision is measured subsequent filtrate 1ml, put in the 20ml measuring bottle, add methanol and be diluted to scale, shake up, survey its curcumin content, result of the test sees Table 5.

Table 5 orthogonal experiments

Conclusion: consider that with the content of curcumin as seen each factor is followed successively by C＞D＞B＞A to the influence degree that effective ingredient extracts, i.e. polyvinylpyrrolidone＞carboxymethyl starch sodium＞dextrin＞lactose, the optimum level of each factor is A ₃B ₁C ₁D ₂, promptly the best proportioning of adjuvant is a lactose: dextrin: polyvinylpyrrolidone: carboxymethyl starch sodium=4: 1: 1: 2.

The clinical experimental data of experimental example 2 powders of the present invention and granule

Powder of the present invention and granule are adopted in this experiment, and bathing treatment aortic arch syndrome is observed its clinical effectiveness.

1 clinical data

1.1 physical data is diagnosed as the patient of acute preceding circulation cerebral infarction, diagnostic criteria is according to the diagnostic criteria of the 4th the cerebrovascular academic conference revision in the whole nation.Age 40-80 year, male or female.Clear and definite focal neurological signs is arranged, and neurologic impairment NIHSS scoring is the 4-18 branch.Should fall ill first or fall ill in the past and do not leave the MRS of morbidity once more≤1 of sequela such as quadriplegia.

1.2 getting rid of, exclusion standard confirms on inspection by causers such as intracranial spaceoccupying lesions; The subarachnoid hemorrhage person; Back circulation infraction person; Using thrombolytic, anticoagulant, antiplatelet drug person; Gestation, women breast-feeding their children; Dysphagia and can not cooperation person; Other serious delayed ischemic neurological deficits persons such as multiple sclerosis, amyotrophic lateral sclerosis, tumor and hydrocephalus person, the long and patient that is difficult to treat of the course of disease or take may The Study of Interference medicine (as schizophrenia class medicine and cardiac drug) person; Severe cardiac hepatic renal dysfunction person (surpassing 1.5 times of upper limits of normal) is arranged, hematologic disease and bleeding tendency patient; Known or suspection has anaphylactoid patient's 70 examples to test drug or test Related product.

2 experiment and reagents

2.1 reagent

The lung-pulse ointment (XiZang QiZheng Tibetan pharmaceuticals Co., Ltd provides) of conventional dosage forms;

The lung-pulse ointment 1 (preparation method: 1. Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g are made only, pulverize, mix homogeneously, standby; 2. take by weighing 50% of mixed powder gross weight, decoct with water 1 time, collect volatile oil simultaneously, amount of water is 20 times of medical material gross weight, and 80 ℃ of temperature were fried in shallow oil 1.5 hours, collects decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.0 concentrated solution, and is standby; 3. will remain medicated powder (50%) be ground into the medicated powder of 0.01 ~ 200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ standby; 4. get the 100g lanoline, gained mixed liquor in adding 3. when being warming up to 75 ℃ stirs, and is to place in the homogenizer under the condition of 0.09MPa to stir 20 minutes fast keeping vacuum pressure, treat that temperature reduces to 30 ℃, add and promptly make ointment after the artificial Moschus stirs.)；

The lung-pulse ointment 2 (preparation method: 1. Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g are made only, pulverize, mix homogeneously, standby; 2. take by weighing 50% of mixed powder gross weight, the alcohol reflux with 50% 1 time extracted 1.5 hours, and alcohol adding amount is 20 times of medical material gross weight, and 50 ℃ of temperature are collected extracting solution; Filter, be condensed into proportion and be 1.0 concentrated solution, standby; 3. will remain medicated powder (50%) be ground into the medicated powder of 0.01 ~ 200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ standby; 4. get the 100g lanoline, gained mixed liquor in adding 3. when being warming up to 75 ℃ stirs, and is to place in the homogenizer under the condition of 0.09MPa to stir 20 minutes fast keeping vacuum pressure, treat that temperature reduces to 30 ℃, add and promptly make ointment after the artificial Moschus stirs.)；

The lung-pulse ointment 3 (preparation method: 1. Moschus is ground to form fine powder for 0.08 part; 2. with 20 parts in Rhizoma Curcumae Longae, 5 parts of Semen Myristicaes, 10 parts of Radix Et Rhizoma Nardostachyos, 5 parts of Actinolitum, 8 parts in Radix Glycyrrhizae,, 10 parts of 12 parts of Rhizoma Kaempferiaes, 15 parts of Fructus cari carvis, 8 parts of Rhizoma Acori Calamis, 7 parts in Pericarpium Zanthoxyli, trona pick totally, is ground into the superfine powder that particle diameter is 10 ~ 40 μ m; , 3. get step superfine powder 2. and place container for 20 parts, add 8 parts liquid paraffin therein, 8 parts glycerol, 9 parts of Tween-80s, 0.2 part of methyl hydroxybenzoate, add water to 100 parts, stir system cream at 75 ~ 85 ℃, add Moschus when waiting to be cooled to 35 ~ 40 ℃ and stir, make ointment, discharging, room temperature was placed 3 ~ 8 hours, and the adding antiseptic is an amount of, and packing promptly.)；

Medicine 1 of the present invention (embodiment 1 is prepared from the description according to the present invention), medicine 2 of the present invention (embodiment 15 is prepared from the description according to the present invention).

2.2 Therapeutic Method

Establish respectively: traditional the lung-pulse ointment adds upper limb body physical therapy symptomatic treatment group (I), the lung-pulse ointment 1 and adds upper limb body physical therapy symptomatic treatment group (II), the lung-pulse ointment 2 and add upper limb body physical therapy symptomatic treatment group (III), the lung-pulse ointment 3 and add that upper limb body physical therapy symptomatic treatment group (IV), medicine of the present invention 1 add upper limb body physical therapy symptomatic treatment group (V), medicine of the present invention 2 adds upper limb body physical therapy symptomatic treatment group (VI).Get an amount of eliminating cold for resuscitation water of medicine of the present invention brew (1000～1500ml), soak to suffer from limb 15～30 minutes, every day 2 times, 7 days was 1 course of treatment, other each groups are smeared corresponding the lung-pulse ointment, are applied to the lung-pulse in right amount and follow capable position 2～3 times/day, observe the curative effect after four courses of treatment.

2.3 curative effect determinate standard

The evaluation of muscular tension is by international Ashworth standards of grading, and promptly 0 grade: muscular tension is normal; The I level: muscular tension slightly increases, and when getting involved the part passive flexion and extension, unexpected blocking do not appear in ROM, discharges then or minimum resistance occurs; The I+ level: muscular tension slightly increases, and during passive flexion and extension, occurs suddenly in 50% scope blocking behind ROM, when the ROM inspection is carried through to the end in continuation, little resistance is arranged all the time; The II level: muscular tension more obviously increases, and during by ROM most of, resistance all more significantly increases, but the part of getting involved still can more easily move; The III level: muscular tension seriously increases, and carries out the ROM inspection and has any problem; The IV level, stiff, the part of getting involved can not be bent and stretched.Cure: 0 grade of muscular tension; Produce effects: muscular tension decline two-stage or more than the two-stage; Effectively: muscular tension decline one-level; Invalid: muscular tension does not descend or raises.

3 results

The patient after 4 courses of treatment is treated in observation, and compares result such as table 6 with other group therapeutic effect.

Table 6 powder of the present invention and the treatment of granule bathing are to the change evaluation of patient's limbs muscular tension after the apoplexy

Patient's muscular hypertonia was effective after data result showed the lung-pulse Ointment in Treatment apoplexy, medicine 1 of the present invention and medicine of the present invention 2 adopt bathing treatment aortic arch syndrome, all can improve the utilization rate of medicine, reach better therapeutic effect, total effective rate is higher than total effective rate that traditional the lung-pulse ointment, the lung-pulse ointment 1, the lung-pulse ointment 2, the lung-pulse ointment 3 add each group of upper limb body physical therapy symptomatic treatment.

Following embodiment all can realize the described effect of above-mentioned experimental example.

The specific embodiment

Embodiment 1: powder of the present invention

Crude drug and adjuvant are formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g, methyl hydroxybenzoate 4.5g.

Preparation method:

3. the artificial Moschus is ground to form fine powder;

4. will remain hybrid medicine and be ground into the superfine powder that particle diameter is 0.1-1 μ m;

5. with above-mentioned concentrated solution a drying, pulverize, add above-mentioned artificial Moschus's fine powder, superfine powder, methyl hydroxybenzoate, mix homogeneously, packing is promptly; Extraction ratio is 12.50%, and per 1 gram powder contains crude drug 1.0g.

Embodiment 2: powder of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g;

Preparation method:

2. Moschus is ground to form fine powder;

3. the superfine powder that Moschus fine powder that 2. step is obtained and above-mentioned steps make in 1., mix homogeneously, packing is promptly; Per 1 gram powder contains crude drug 1.0g.

Embodiment 3: powder of the present invention

Crude drug and adjuvant consist of:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g, sodium benzoate 5.0g;

Preparation method:

2. take by weighing 50% of above-mentioned mixed material medicine total amount, with 50% ethanol extraction of 20 times of weight 1 time, extracted 1.5 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.15-1.25;

3. Moschus is ground to form fine powder;

4. will remain hybrid medicine and be ground into the superfine powder that particle diameter is 10-40 μ m;

5. with above-mentioned concentrated solution a drying, pulverize, add above-mentioned Moschus fine powder, superfine powder, sodium benzoate, mix homogeneously, packing is promptly; Extraction ratio is 14.92%, per 1 gram powder contains crude drug 1.0g.

Embodiment 4: powder of the present invention

Crude drug consists of:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g, ethyl hydroxybenzoate 5g;

Preparation method:

2. the artificial Moschus is ground to form fine powder;

3. medicated powder, ethyl hydroxybenzoate mix homogeneously that artificial Moschus's fine powder that 2. step is obtained and above-mentioned steps make in 1., packing is promptly; Per 1 gram powder contains crude drug 1.0g.

Embodiment 5: powder of the present invention

Crude drug and adjuvant consist of:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g, ethyl hydroxybenzoate 2.5g;

Preparation method:

3. Moschus is ground to form fine powder;

4. will remain hybrid medicine and be ground into the medicated powder that particle diameter is 60-90 μ m;

5. with above-mentioned concentrated solution a drying, pulverize, add above-mentioned Moschus fine powder, medicated powder, ethyl hydroxybenzoate, mix homogeneously, packing is promptly; Extraction ratio is 13.58%, per 1 gram powder contains crude drug 1.0g.

Embodiment 6: powder of the present invention

Crude drug consists of:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g, butoben 9g;

Preparation method:

2. Moschus is ground to form fine powder;

3. medicated powder, butoben that Moschus fine powder that 2. step is obtained and above-mentioned steps make in 1., mix homogeneously, packing is promptly; Per 1 gram powder contains crude drug 1.0g.

Embodiment 7: powder of the present invention

Crude drug consists of:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g, sodium benzoate 1g;

Preparation method:

2. take by weighing 20% of above-mentioned mixed material medicine total amount, with 40% ethanol extraction of 15 times of weight 3 times, extracted 1 hour at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.35-1.45;

3. Moschus is ground to form fine powder;

4. will remain hybrid medicine and be ground into the medicated powder that particle diameter is 1-10 μ m;

5. with above-mentioned concentrated solution a drying, pulverize, add above-mentioned Moschus fine powder, medicated powder, sodium benzoate, mix homogeneously, packing is promptly; Extraction ratio is 11.92%, per 1 gram powder contains crude drug 1.0g.

Embodiment 8: powder of the present invention

Crude drug consists of:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g, methyl hydroxybenzoate 1g;

Preparation method:

1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are carried out remove impurity, cleaning, drying respectively, be ground into the medicated powder that particle diameter is 0.1-1 μ m;

2. Moschus is ground to form fine powder;

3. medicated powder, methyl hydroxybenzoate that Moschus fine powder that 2. step is obtained and above-mentioned steps make in 1., mix homogeneously, packing is promptly; Per 1 gram powder contains crude drug 1.0g.

Embodiment 9: powder of the present invention

Crude drug and adjuvant consist of:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g, butoben 3.0g;

Preparation method:

3. the artificial Moschus is ground to form fine powder;

4. will remain hybrid medicine and be ground into the medicated powder that particle diameter is 40-60 μ m;

5. with above-mentioned concentrated solution a drying, pulverize, add above-mentioned Moschus fine powder, medicated powder, butoben, mix homogeneously, packing is promptly; Extraction ratio is 13.61%, per 1 gram powder contains crude drug 1.0g.

Embodiment 10: powder of the present invention

Crude drug consists of:

Preparation method:

1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are carried out remove impurity, cleaning, drying respectively, be ground into the medicated powder that particle diameter is 10-40 μ m;

2. Moschus is ground to form fine powder;

3. the medicated powder that Moschus fine powder that 2. step is obtained and above-mentioned steps make in 1., mix homogeneously, packing is promptly; Per 1 gram powder contains crude drug 1.0g.

Embodiment 11: powder of the present invention

Crude drug consists of:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g;

Preparation method:

2. take by weighing above-mentioned mixed material medicine, use 60% ethanol extraction 3 times of 10,8,6 times of medicine gross weights respectively, extracted respectively 90,60,30 minutes at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.05-1.15;

3. the artificial Moschus is ground to form fine powder;

4. with above-mentioned concentrated solution a drying, pulverize, add above-mentioned Moschus fine powder, medicated powder, mix homogeneously, packing is promptly; Extraction ratio is 14.57%, per 1 gram powder contains crude drug 1.0g.

Embodiment 12: powder of the present invention

Crude drug consists of:

Preparation method:

2. Moschus is ground to form fine powder;

Embodiment 13: granule of the present invention

Crude drug is formed:

Adjuvant consists of:

Lactose 67g, dextrin 16.5g, polyvinylpyrrolidone 16.5g, carboxymethyl starch sodium 33.5g.

Preparation method:

2. Moschus is ground to form fine powder;

3. superfine powder, lactose, dextrin, polyvinylpyrrolidone, carboxymethyl starch sodium that Moschus fine powder that 2. step is obtained and above-mentioned steps make in 1., mix homogeneously is granulated with spray granulation, granulate, packing is promptly; Per 1 gram granule contains crude drug 0.6g.

Embodiment 14: granule of the present invention

Crude drug is formed:

Adjuvant consists of:

Preparation method:

1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are carried out remove impurity, cleaning, drying respectively, be ground into the superfine powder that particle diameter is 60-90 μ m;

2. Moschus is ground to form fine powder;

Embodiment 15: granule of the present invention

Crude drug is formed:

Adjuvant consists of:

Lactose 88g, dextrin 22g, polyvinylpyrrolidone 22g, carboxymethyl starch sodium 44g, ethyl hydroxybenzoate 5.0g.

2. take by weighing 10% of above-mentioned mixed material medicine total amount, with 30% ethanol extraction of 5 times of weight 4 times, extracted 3 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.25-1.35;

3. the artificial Moschus is ground to form fine powder;

4. will remain hybrid medicine and be ground into the superfine powder that particle diameter is 0.1-1 μ m, and with above-mentioned concentrated solution a, artificial Moschus's fine powder, lactose, dextrin, polyvinylpyrrolidone, carboxymethyl starch sodium, ethyl hydroxybenzoate, mix homogeneously is granulated with spray granulation, granulate, packing are promptly; The extractum extraction ratio is 21.56%, and per 1 gram granule contains crude drug 0.6g.

Embodiment 16: granule of the present invention

Crude drug is formed:

Adjuvant consists of:

Lactose 400g, dextrin 100g, polyvinylpyrrolidone 100g, carboxymethyl starch sodium 200g.

Preparation method:

2. the artificial Moschus is ground to form fine powder;

3. superfine powder, lactose, dextrin, polyvinylpyrrolidone, carboxymethyl starch sodium that artificial Moschus's fine powder that 2. step is obtained and above-mentioned steps make in 1., mix homogeneously is granulated with spray granulation, granulate, packing is promptly; Per 1 gram granule contains crude drug 0.2g.

Embodiment 17: granule of the present invention

Crude drug is formed:

Adjuvant consists of:

Lactose 415g, dextrin 104g, polyvinylpyrrolidone 104g, carboxymethyl starch sodium 207.5g, sodium benzoate 3.5g.

Preparation method:

3. Moschus is ground to form fine powder;

4. will remain hybrid medicine and be ground into the superfine powder that particle diameter is 1-10 μ m, and with above-mentioned concentrated solution a, Moschus fine powder, lactose, dextrin, polyvinylpyrrolidone, carboxymethyl starch sodium, sodium benzoate, mix homogeneously is granulated with spray granulation, granulate, packing are promptly; Extraction ratio is 24.12%, per 1 gram granule contains crude drug 0.2g.

Embodiment 18: granule of the present invention

Crude drug is formed:

Adjuvant consists of:

Lactose 100g, dextrin 25g, polyvinylpyrrolidone 25g, carboxymethyl starch sodium 50g, butoben 5.0g.

Preparation method:

2. the artificial Moschus is ground to form fine powder;

3. superfine powder, lactose, dextrin, polyvinylpyrrolidone, carboxymethyl starch sodium, butoben that artificial Moschus's fine powder that 2. step is obtained and above-mentioned steps make in 1., mix homogeneously is granulated with spray granulation, granulate, packing is promptly; Per 1 gram granule contains crude drug 0.5g.

Embodiment 19: granule of the present invention

Crude drug is formed:

Adjuvant consists of:

Lactose 1938g, dextrin 484.5g, polyvinylpyrrolidone 484.5g, carboxymethyl starch sodium 969g.

Preparation method:

3. the artificial Moschus is ground to form fine powder;

4. will remain hybrid medicine and be ground into the superfine powder that particle diameter is 10-40 μ m, and with above-mentioned concentrated solution a, artificial Moschus's fine powder, lactose, dextrin, polyvinylpyrrolidone, carboxymethyl starch sodium, mix homogeneously is granulated with spray granulation, granulate, packing is promptly; Extraction ratio is 24.22%, per 1 gram granule contains crude drug 0.05g.

Embodiment 20: granule of the present invention

Crude drug is formed:

Adjuvant consists of:

Lactose 100g, dextrin 25g, polyvinylpyrrolidone 25g, carboxymethyl starch sodium 50g.

Preparation method:

2. Moschus is ground to form fine powder;

3. medicated powder, lactose, dextrin, polyvinylpyrrolidone, carboxymethyl starch sodium that Moschus fine powder that 2. step is obtained and above-mentioned steps make in 1., mix homogeneously is granulated with spray granulation, granulate, packing is promptly; Per 1 gram granule contains crude drug 0.5g.

Embodiment 21: granule of the present invention

Crude drug is formed:

Adjuvant consists of:

Lactose 160g, dextrin 40g, polyvinylpyrrolidone 40g, carboxymethyl starch sodium 80g, methyl hydroxybenzoate 6.5g.

Preparation method:

3. the artificial Moschus is ground to form fine powder;

4. will remain hybrid medicine and be ground into the medicated powder that particle diameter is 40-60 μ m, and with above-mentioned concentrated solution a, artificial Moschus's fine powder, lactose, dextrin, polyvinylpyrrolidone, carboxymethyl starch sodium, methyl hydroxybenzoate, mix homogeneously is granulated with spray granulation, granulate, packing are promptly; Extraction ratio is 20.78%, per 1 gram granule contains crude drug 0.5g.

Embodiment 22: granule of the present invention

Crude drug consists of:

Adjuvant consists of:

Preparation method:

The A method:

2. Moschus is ground to form fine powder;

Embodiment 23: granule of the present invention

Crude drug consists of:

Adjuvant consists of:

Lactose 168g, dextrin 42g, polyvinylpyrrolidone 42g, carboxymethyl starch sodium 84g.

Preparation method:

2. take by weighing 90% of above-mentioned mixed material medicine total amount, with 90% ethanol extraction of 10 times of weight 1 time, extracted 24 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.15-1.25;

3. the artificial Moschus is ground to form fine powder;

4. will remain hybrid medicine and be ground into the medicated powder that particle diameter is 60-90 μ m, and with above-mentioned concentrated solution a, artificial Moschus's fine powder, lactose, dextrin, polyvinylpyrrolidone, carboxymethyl starch sodium, mix homogeneously is granulated with spray granulation, granulate, packing is promptly; Extraction ratio is 25.02%, per 1 gram granule contains crude drug 0.5g.

Embodiment 24: granule of the present invention

Crude drug is formed:

Adjuvant consists of:

Preparation method:

2. Moschus is ground to form fine powder;

3. medicated powder, lactose, dextrin, polyvinylpyrrolidone, carboxymethyl starch sodium that Moschus fine powder that 2. step is obtained and above-mentioned steps make in 1., mix homogeneously is granulated with spray granulation, granulate, packing is promptly; Per 1 gram granule contains crude drug 0.6g.

Embodiment 25: granule of the present invention

Crude drug is formed:

Adjuvant consists of:

Lactose 144g, dextrin 36g, polyvinylpyrrolidone 36g, carboxymethyl starch sodium 72g.

Preparation method:

3. the artificial Moschus is ground to form fine powder;

4. with above-mentioned concentrated solution a, artificial Moschus's fine powder, lactose, dextrin, polyvinylpyrrolidone, carboxymethyl starch sodium, mix homogeneously, with the spray granulation granulate of granulating, packing is promptly; Extraction ratio is 22.65%, per 1 gram granule contains crude drug 0.6g.

Claims

1. powder for the treatment of aortic arch syndrome, its crude drug consists of: Rhizoma Curcumae Longae 30-40 weight portion, Semen Myristicae 10-15 weight portion, Radix Et Rhizoma Nardostachyos 15-25 weight portion, Actinolitum 10-15 weight portion, Radix Glycyrrhizae 15-20 weight portion, artificial Moschus or Moschus 0.15-0.2 weight portion, Rhizoma Zingiberis 20-28 weight portion, Fructus cari carvi 28-35 weight portion, Rhizoma Acori Calami 15-20 weight portion, Pericarpium Zanthoxyli 10-15 weight portion, trona 15-20 weight portion; The adjuvant that it is characterized in that this powder consists of:

2. the powder of treatment aortic arch syndrome as claimed in claim 1 is characterized in that the adjuvant of this powder consists of:

3. the powder of treatment aortic arch syndrome as claimed in claim 1 is characterized in that the adjuvant of this powder consists of:

4. as the powder of the arbitrary described treatment aortic arch syndrome of claim 1-3, it is characterized in that the crude drug of this powder consists of:

5. as the preparation method of the powder of the arbitrary described treatment aortic arch syndrome of claim 1-4, it is characterized in that this method comprises a kind of in following A and the B method:

The A method:

2. artificial Moschus or Moschus are ground to form fine powder;

3. the medicated powder mix homogeneously that makes in 1. of artificial Moschus that 2. step is obtained or Moschus fine powder and above-mentioned steps or add antibacterial is again made powder;

The B method:

2. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into medicated powder and above-mentioned concentrated solution a, artificial Moschus or the Moschus fine powder mix homogeneously that particle diameter is 0.1-150 μ m, or add antibacterial again, make powder.

6. the preparation method of the powder of treatment aortic arch syndrome as claimed in claim 5 is characterized in that this method comprises a kind of in following A and the B method:

The A method:

2. artificial Moschus or Moschus are ground to form fine powder;

3. the superfine powder mix homogeneously that makes in 1. of artificial Moschus that 2. step is obtained or Moschus fine powder and above-mentioned steps or add antibacterial is again made powder;

The B method:

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into superfine powder and above-mentioned concentrated solution a, artificial Moschus or the Moschus fine powder mix homogeneously that particle diameter is 0.1-1 μ m, or add antibacterial again, make powder.

7. the preparation method of the powder of treatment aortic arch syndrome as claimed in claim 5 is characterized in that this method comprises a kind of in following A and the B method:

The A method:

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into superfine powder and above-mentioned concentrated solution a, artificial Moschus or the Moschus fine powder mix homogeneously that particle diameter is 1-10 μ m, or add antibacterial again, make powder.

8. the preparation method of the powder of treatment aortic arch syndrome as claimed in claim 5 is characterized in that this method comprises a kind of in following A and the B method:

The A method:

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into superfine powder and above-mentioned concentrated solution a, artificial Moschus or the Moschus fine powder mix homogeneously that particle diameter is 10-40 μ m, or add antibacterial again, make powder.

9. the preparation method of the powder of treatment aortic arch syndrome as claimed in claim 5 is characterized in that this method comprises a kind of in following A and the B method:

The A method:

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into medicated powder and above-mentioned concentrated solution a, artificial Moschus or the Moschus fine powder mix homogeneously that particle diameter is 40-60 μ m, or add antibacterial again, make powder.

10. the preparation method of the powder of treatment aortic arch syndrome as claimed in claim 5 is characterized in that this method comprises a kind of in following A and the B method:

The A method:

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into medicated powder and above-mentioned concentrated solution a, artificial Moschus or the Moschus fine powder mix homogeneously that particle diameter is 60-90 μ m, or add antibacterial again, make powder.

11. the preparation method of the powder of treatment aortic arch syndrome as claimed in claim 5 is characterized in that this method comprises a kind of in following A and the B method:

The A method:

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

3. artificial Moschus or Moschus are ground to form fine powder;

4. with above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder mix homogeneously, or add antibacterial again, make powder.

12. be used for the application of the medicine of relaxing muscles and tendons and activating QI and blood in the collateral in preparation as the powder of the arbitrary described treatment aortic arch syndrome of claim 1-4.

13. a granule for the treatment of aortic arch syndrome, its crude drug consists of: Rhizoma Curcumae Longae 30-40 weight portion, Semen Myristicae 10-15 weight portion, Radix Et Rhizoma Nardostachyos 15-25 weight portion, Actinolitum 10-15 weight portion, Radix Glycyrrhizae 15-20 weight portion, artificial Moschus or Moschus 0.15-0.2 weight portion, Rhizoma Zingiberis 20-28 weight portion, Fructus cari carvi 28-35 weight portion, Rhizoma Acori Calami 15-20 weight portion, Pericarpium Zanthoxyli 10-15 weight portion, trona 15-20 weight portion; The adjuvant that it is characterized in that this granule consists of:

14. the granule of treatment aortic arch syndrome as claimed in claim 13 is characterized in that the adjuvant of this granule consists of:

15., it is characterized in that the adjuvant of this granule consists of as the granule of claim 13 or 14 described treatment aortic arch syndromes:

16., it is characterized in that the crude drug of this granule consists of as the granule of the arbitrary described treatment aortic arch syndrome of claim 13-15:

17., it is characterized in that this method comprises a kind of in following A and the B method as the preparation method of the granule of the arbitrary described treatment aortic arch syndrome of claim 13-16:

The A method:

2. artificial Moschus or Moschus are ground to form fine powder;

3. the medicated powder and the adjuvant mix homogeneously that make in 1. of artificial Moschus that 2. step is obtained or Moschus fine powder and above-mentioned steps made granule;

The B method:

2. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into medicated powder and above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder and the adjuvant mix homogeneously that particle diameter is 0.1-150 μ m, make granule.

18. the preparation method of the granule of treatment aortic arch syndrome as claimed in claim 17 is characterized in that this method comprises a kind of in following A and the B method:

The A method:

2. artificial Moschus or Moschus are ground to form fine powder;

3. the superfine powder and the adjuvant mix homogeneously that make in 1. of artificial Moschus that 2. step is obtained or Moschus fine powder and above-mentioned steps made granule;

The B method:

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into superfine powder and above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder and the adjuvant mix homogeneously that particle diameter is 0.1-1 μ m, make granule.

19. the preparation method of the granule of treatment aortic arch syndrome as claimed in claim 17 is characterized in that this method comprises a kind of in following A and the B method:

The A method:

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into superfine powder and above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder and the adjuvant mix homogeneously that particle diameter is 1-10 μ m, make granule.

20. the preparation method of the granule of treatment aortic arch syndrome as claimed in claim 17 is characterized in that this method comprises a kind of in following A and the B method:

The A method:

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into superfine powder and above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder and the adjuvant mix homogeneously that particle diameter is 10-40 μ m, make granule.

21. the preparation method of the granule of treatment aortic arch syndrome as claimed in claim 17 is characterized in that this method comprises a kind of in following A and the B method:

The A method:

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into medicated powder and above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder and the adjuvant mix homogeneously that particle diameter is 40-60 μ m, make granule.

22. the preparation method of the granule of treatment aortic arch syndrome as claimed in claim 17 is characterized in that this method comprises a kind of in following A and the B method:

The A method:

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

3. artificial Moschus or Moschus are ground to form fine powder;

4. will remain hybrid medicine and be ground into medicated powder and above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder and the adjuvant mix homogeneously that particle diameter is 60-90 μ m, make granule.

23. the preparation method of the granule of treatment aortic arch syndrome as claimed in claim 17 is characterized in that this method comprises a kind of in following A and the B method:

The A method:

2. artificial Moschus or Moschus are ground to form fine powder;

The B method:

3. artificial Moschus or Moschus are ground to form fine powder;

4. with above-mentioned concentrated solution a, artificial Moschus or Moschus fine powder and adjuvant mix homogeneously, make granule.

24. be used for the application of the medicine of relaxing muscles and tendons and activating QI and blood in the collateral in preparation as the granule of the arbitrary described treatment aortic arch syndrome of claim 13-16.