CN101698095B - Drug composition liniment or lotion for treating white vein diseases and preparation method thereof - Google Patents
Drug composition liniment or lotion for treating white vein diseases and preparation method thereof Download PDFInfo
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- CN101698095B CN101698095B CN2009102112621A CN200910211262A CN101698095B CN 101698095 B CN101698095 B CN 101698095B CN 2009102112621 A CN2009102112621 A CN 2009102112621A CN 200910211262 A CN200910211262 A CN 200910211262A CN 101698095 B CN101698095 B CN 101698095B
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Abstract
The invention discloses a drug composition liniment or lotion for treating white vein diseases and a preparation method thereof. The liniment or lotion is obtained by dosage form preparation with the prescription of white vein ointments, namely the traditional Tibetan drugs as the basic prescription. The invention adopts the preparation method of extracting part of the drugs and processing the other part of the drugs in an ultramicro manner, thus not only effectively retaining the active ingredients in the drugs, but also greatly increasing the content of the crude drug components, improving the bioavailability and bettering the curative effects. The liniment or lotion of the invention has the advantages of rapid seepage, lasting effects, obvious curative effects and the like. The preparation method is simple and practical and is easy for industrialization. Together with physiotherapy, the liniment or lotion can improve the curative effects, and the cases with excellent treatment effects are obviously increased. In addition, the liniment or lotion has obvious advantage in improving the efficiency.
Description
Invention field
The present invention relates to a kind of drug composition liniment or lotion and preparation method thereof, particularly a kind of drug composition liniment of treating aortic arch syndrome or lotion and preparation method thereof.
Technical background
The lung-pulse ointment is that the doctor among the people of Tibetan is carried according to " Tibetan medicine doctor certainly addendum releases difficulty ", the Four-Volume Medical Code two secretaries; In conjunction with the classical Tibetan medicine and pharmacology proved recipe that practical experience is formed, the lung-pulse ointment is former to be recorded in first 310 pages of " health drug standard promulgated by the ministries or commissions of the Central Government " 95 years version Tibetan medicines.The prescription of the lung-pulse ointment is:
Rhizoma Curcumae Longae 150g, Semen Myristicae 50g, Radix Et Rhizoma Nardostachyos 80g, Actinolitum 50g, Radix Glycyrrhizae 70g, artificial Moschus or Moschus 0.7g, Rhizoma Kaempferiae 100g, Fructus cari carvi 130g, Rhizoma Acori Calami 70g, Pericarpium Zanthoxyli 50g, JIANHUA 75g.
Method for making: above ten simply, and except that artificial Moschus or other porphyrize powder of Moschus, all the other are ground into fine powder altogether, sieve, and add artificial Moschus or Moschus fine powder facing-up, with butter and Adeps Sus domestica furnishing ointment, promptly get.
Function with cure mainly: relaxing muscles and tendons and activating QI and blood in the collateral.Be used for aortic arch syndrome, paralysis, hemiplegia, the muscle tendon is tetanic, meridians that wound causes and muscle tendon break wound, brothers' contraction urgency, limping etc.
Theoretical according to the Tibetan medicine; Disorders of meridian is divided into the lung-pulse and Hei Mai, and wherein the lung-pulse is the venation that human body at first bears at embryo stage, also is the venation that fetal development obtains nutrition; These venations of birth back play again and absorb diet elite, conveying waste matter; To guarantee the normal circulation of three factors, seven materials,, can cause the generation of various diseases if the function of these venations gets muddled.The main pathogenic factor of aortic arch syndrome has following three aspects: aggravating activities, damage body venation; Pestilent toxicity pathogenic heat etc. is fallen in the arteries and veins; Mechanical damages such as weapons club cause rheumatism; In disorder and go into sering.The Tibetan medicine is the vital energy regualting and blood circulation-promoting collateral dredging to the regulation principle of aortic arch syndrome.Tibetan people is according to the Four-Volume Medical Code, " brilliant pearl book on Chinese herbal medicine " record; In conjunction with long-term practical experience, be the Tibetan medicine the lung-pulse ointment of raw material production with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Moschus, Fructus cari carvi, Pericarpium Zanthoxyli, JIANHUA, receive the trust of extensive patients with significant mass effect; But traditional Tibetan medicine the lung-pulse ointment preparation technology is modulated into ointment after all crude drug fine powders are mixed; Its technology is numerous and diverse, and batch production cycle is long, and production technology is unstable; Raw material and adjuvant source are unstable, are unfavorable for suitability for industrialized production; Part drug osmotic ability, bioavailability is low, can not guarantee curative effect fully, should not bring into play the curative effect of medicine; Product should not be deposited in addition, carries inconvenience; Because each side has greatly influenced the curative effect and the popularization of product.
Summary of the invention
It is drug composition liniment or the lotion that basic square tube is crossed the treatment aortic arch syndrome that dosage changing form prepares that the object of the invention is to disclose a kind of prescription with traditional Tibetan medicine the lung-pulse ointment, and the object of the invention also is to disclose the method for preparing of this liniment or lotion.
The present invention seeks to realize through following technical scheme.
The crude drug of liniment of the present invention or lotion is formed and consumption is:
Rhizoma Curcumae Longae 30-40 weight portion, Semen Myristicae 10-15 weight portion, Radix Et Rhizoma Nardostachyos 15-25 weight portion, Actinolitum 10-15 weight portion, Radix Glycyrrhizae 15-20 weight portion, artificial Moschus or Moschus 0.15-0.2 weight portion, Rhizoma Zingiberis 20-28 weight portion, Fructus cari carvi 28-35 weight portion, Rhizoma Acori Calami 15-20 weight portion, Pericarpium Zanthoxyli 10-15 weight portion, JIANHUA 15-20 weight portion.
The crude drug of liniment of the present invention or lotion is formed and consumption is preferably:
Rhizoma Curcumae Longae 36.3 weight portions, Semen Myristicae 12.1 weight portions, Radix Et Rhizoma Nardostachyos 19.4 weight portions, Actinolitum 12.1 weight portions, Radix Glycyrrhizae 17.0 weight portions, artificial Moschus or Moschus 0.17 weight portion, Rhizoma Zingiberis 24.2 weight portions, Fructus cari carvi 31.5 weight portions, Rhizoma Acori Calami 17.0 weight portions, Pericarpium Zanthoxyli 12.1 weight portions, JIANHUA 18.2 weight portions.
The adjuvant of liniment of the present invention or lotion is formed and consumption is:
Ethanol 15-300 weight portion, glycerol 10-200 weight portion, liquid paraffin 5-100 weight portion, azone 5-100 weight portion and distilled water 150-4200 parts by volume; Or distilled water 150-4200 parts by volume.
The adjuvant of liniment of the present invention or lotion is formed and consumption is preferably:
Ethanol 150 weight portions, glycerol 100 weight portions, liquid paraffin 15 weight portions, azone 50 weight portions and distilled water 2200 parts by volume;
Or ethanol 20 weight portions, glycerol 190 weight portions, liquid paraffin 25 weight portions, azone 90 weight portions and distilled water 160 parts by volume;
Or ethanol 290 weight portions, glycerol 20 weight portions, liquid paraffin 6 weight portions, azone 10 weight portions and distilled water 4100 parts by volume;
Or ethanol 110 weight portions, glycerol 45 weight portions, liquid paraffin 15 weight portions, azone 24 weight portions and distilled water 650 parts by volume;
Or ethanol 85 weight portions, glycerol 30 weight portions, liquid paraffin 12 weight portions, azone 15 weight portions and distilled water 550 parts by volume;
Or ethanol 92 weight portions, glycerol 45 weight portions, liquid paraffin 18 weight portions, azone 25 weight portions and distilled water 250 parts by volume;
Or ethanol 70 weight portions, glycerol 25 weight portions, liquid paraffin 7 weight portions, azone 12 weight portions and distilled water 120 parts by volume;
Or alcohol 95 weight portion, glycerol 30 weight portions, liquid paraffin 10 weight portions, azone 18 weight portions and distilled water 300 parts by volume;
Or ethanol 300 weight portions, glycerol 145 weight portions, liquid paraffin 45 weight portions, azone 60 weight portions and distilled water 3400 parts by volume;
Or ethanol 300 weight portions, glycerol 200 weight portions, liquid paraffin 100 weight portions, azone 100 weight portions and distilled water 4200 parts by volume;
Or distilled water 2200 parts by volume; Or distilled water 500 parts by volume; Or distilled water 4200 parts by volume; Or distilled water 700 parts by volume; Or distilled water 850 parts by volume; Or distilled water 800 parts by volume; Or distilled water 150 parts by volume; Or distilled water 250 parts by volume; Or distilled water 3500 parts by volume.
The method for preparing of liniment of the present invention or lotion comprises the steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing the 10%-100% of above-mentioned mixed material medicine total amount; Boil 1-4 time with 5-20 times of weight decocting; The each decoction 0.5-3 hour, collection, merge extractive liquid, and volatile oil, it is the concentrated solution of 1.0-1.5 that filtration and concentrated extracting solution become relative density; And volatile oil joined in the concentrated solution, concentrated solution a;
3. will remain mixed material medicated powder and be broken into the medicated powder that particle diameter is 0.1-150 μ m;
4. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the medicated powder that 3. step obtains; The b that 4. step obtains stirs mix homogeneously at any time fast; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment of the present invention; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the medicated powder that 3. step obtains, and the b that 4. step obtains stirs at any time fast, and mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion of the present invention.
The method for preparing of liniment of the present invention or lotion preferably includes following steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 10% of above-mentioned mixed material medicine total amount, boil 4 times, decocted 3 hours at every turn with 5 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.25-1.35 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the superfine powder that particle diameter is 0.1-1 μ m;
4. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the superfine powder that 3. step obtains; The b that 4. step obtains stirs mix homogeneously at any time fast; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment of the present invention; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the medicated powder that 3. step obtains, and the b that 4. step obtains stirs at any time fast, and mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion of the present invention.
The method for preparing of liniment of the present invention or lotion preferably includes following steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 20% of above-mentioned mixed material medicine total amount, boil 3 times, decocted 1 hour at every turn with 15 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.35-1.45 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the superfine powder that particle diameter is 1-10 μ m;
4. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the superfine powder that 3. step obtains; The b that 4. step obtains stirs mix homogeneously at any time fast; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment of the present invention; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the medicated powder that 3. step obtains, and the b that 4. step obtains stirs at any time fast, and mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion of the present invention.
The method for preparing of liniment of the present invention or lotion preferably includes following steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 50% of above-mentioned mixed material medicine total amount, boil 1 time, decocted 1.5 hours at every turn with 20 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.15-1.25 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the superfine powder that particle diameter is 10-40 μ m;
4. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the superfine powder that 3. step obtains; The b that 4. step obtains stirs mix homogeneously at any time fast; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment of the present invention; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the medicated powder that 3. step obtains, and the b that 4. step obtains stirs at any time fast, and mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion of the present invention.
The method for preparing of liniment of the present invention or lotion preferably includes following steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 60% of above-mentioned mixed material medicine total amount, boil 2 times, decocted 2.5 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the medicated powder that particle diameter is 40-60 μ m;
4. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the medicated powder that 3. step obtains; The b that 4. step obtains stirs mix homogeneously at any time fast; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment of the present invention; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the medicated powder that 3. step obtains, and the b that 4. step obtains stirs at any time fast, and mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion of the present invention.
The method for preparing of liniment of the present invention or lotion preferably includes following steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 80% of above-mentioned mixed material medicine total amount, boil 3 times, decocted 1.5 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.25-1.35 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the medicated powder that particle diameter is 90-150 μ m;
4. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the medicated powder that 3. step obtains; The b that 4. step obtains stirs mix homogeneously at any time fast; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment of the present invention; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the medicated powder that 3. step obtains, and the b that 4. step obtains stirs at any time fast, and mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion of the present invention.
The method for preparing of liniment of the present invention or lotion preferably includes following steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 90% of above-mentioned mixed material medicine total amount, boil 2 times, decocted 2.5 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.15-1.25 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the medicated powder that particle diameter is 60-90 μ m;
4. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the medicated powder that 3. step obtains; The b that 4. step obtains stirs mix homogeneously at any time fast; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment of the present invention; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the medicated powder that 3. step obtains, and the b that 4. step obtains stirs at any time fast, and mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion of the present invention.
The method for preparing of liniment of the present invention or lotion preferably includes following steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing above-mentioned mixed material medicine, boil 3 times, decocted 2 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
4. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the b that 3. step obtains; At any time stir fast; Mix homogeneously filters, and adds distilled water and constantly stirring then at leisure; Be filled into bottle, promptly make liniment of the present invention; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the b that 3. step obtains, and stirring fast at any time, mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion of the present invention.
Liniment of the present invention or lotion are compared with prior art the lung-pulse ointment has following characteristics:
1, liniment of the present invention or lotion have advantages such as quick permeation, persistent, therapeutic effect be obvious.
2, method for preparing of the present invention is simple, is easy to industrialization.
3, with liniment of the present invention or lotion, add the therapeutic effect that the limbs physical therapy can improve medicine, treatment reaches produce effects case showed increased, on the raising effective percentage, remarkable advantages is arranged.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
Experimental example 1 liniment of the present invention and lotion to apoplexy after the clinical trial that changes of patient's limbs muscular tension observe
Tradition the lung-pulse ointment has the effect of relaxing muscles and tendons and activating QI and blood in the collateral, is mainly used in aortic arch syndrome clinically, paralysis, and hemiplegia, the muscle tendon is tetanic, meridians that wound causes and muscle tendon break wound, brothers' contraction urgency, limping etc.Adopt liniment of the present invention and lotion, clean cooperation limbs physical therapy treatment aortic arch syndrome, observe its clinical effectiveness.
1 clinical data
1.1 physical data is diagnosed as the patient of acute preceding circulation cerebral infarction, diagnostic criteria is according to the diagnostic criteria of the 4th the cerebrovascular academic conference revision in the whole nation.Age 40-80 year, male or female.Clear and definite focal neurological signs is arranged, and neurologic impairment NIHSS scoring is the 4-18 branch.Should fall ill first or fall ill in the past and do not leave the MRS of morbidity once more≤1 of sequela such as quadriplegia.
1.2 getting rid of, exclusion standard confirms on inspection by causers such as intracranial spaceoccupying lesions; The subarachnoid hemorrhage person; Back circulation infraction person; Using thrombolytic, anticoagulant, antiplatelet drug person; Gestation, women breast-feeding their children; Dysphagia and can not cooperation person; Other serious delayed ischemic neurological deficits persons such as multiple sclerosis, amyotrophic lateral sclerosis, tumor and hydrocephalus person, the long and patient that is difficult to treat of the course of disease or take maybe The Study of Interference medicine (like schizophrenia class medicine and cardiac drug) person; Severe cardiac hepatic renal dysfunction person (surpassing 1.5 times of ULN) is arranged, BLOOD DISEASE and bleeding tendency patient; Known or suspection has anaphylactoid patient's 64 examples to test drug or test Related product.
2 experiments and reagent
2.1 reagent
Medicine 1 of the present invention (embodiment 1 is prepared from the description according to the present invention);
Medicine 2 of the present invention (embodiment 7 is prepared from the description according to the present invention), the lung-pulse ointment (XiZang QiZheng Tibetan pharmaceuticals Co., Ltd provides) of conventional dosage forms;
The lung-pulse ointment 1 (method for preparing: 1. Moschus is ground to form fine powder for 0.08 part; 2. with 20 parts in Rhizoma Curcumae Longae, 5 parts of Semen Myristicaes, 10 parts of Radix Et Rhizoma Nardostachyos, 5 parts of Actinolitum, 8 parts in Radix Glycyrrhizae,, 10 parts of 12 parts of Rhizoma Kaempferiaes, 15 parts of Fructus cari carvis, 8 parts of Rhizoma Acori Calamis, 7 parts in Pericarpium Zanthoxyli, JIANHUA pick totally, is ground into the superfine powder that particle diameter is 10 ~ 40 μ m; , 3. get step superfine powder 2. and place container for 20 parts, add 8 parts liquid paraffin therein, 8 parts glycerol; 9 parts of Tween-80s, 0.2 part of methyl hydroxybenzoate adds water to 100 parts, stirs system cream at 75 ~ 85 ℃; Add Moschus when waiting to be cooled to 35 ~ 40 ℃ and stir, process ointment, discharging; Room temperature was placed 3 ~ 8 hours, and the adding antiseptic is an amount of, and packing promptly gets.)；
The lung-pulse ointment 2 (method for preparing: 1. Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, JIANHUA 9g are made only, pulverize, mix homogeneously, subsequent use; 2. take by weighing 50% of mixed powder gross weight, volatile oil is collected in decocte with water 1 time simultaneously, and amount of water is 20 times of medical material gross weight, and 80 ℃ of temperature were fried in shallow oil 1.5 hours, collects decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.0 concentrated solution, and is subsequent use; 3. will remain medicated powder (50%) be ground into the medicated powder of 0.01 ~ 200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ subsequent use; 4. get the 100g lanoline; Gained mixed liquor in adding 3. when being warming up to 75 ℃ stirs, and is to place in the homogenizer under the condition of 0.09MPa to stir 20 minutes fast keeping vacuum pressure; Treat that temperature reduces to 30 ℃, add and promptly process ointment after the artificial Moschus stirs.)；
The lung-pulse ointment 3 (method for preparing: 1. Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, JIANHUA 9g are made only, pulverize, mix homogeneously, subsequent use; 2. take by weighing 50% of mixed powder gross weight, the alcohol reflux with 50% 1 time extracted 1.5 hours, and alcohol adding amount is 20 times of medical material gross weight, and 50 ℃ of temperature are collected extracting solution; Filter, be condensed into proportion and be 1.0 concentrated solution, subsequent use; 3. will remain medicated powder (50%) be ground into the medicated powder of 0.01 ~ 200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ subsequent use; 4. get the 100g lanoline; Gained mixed liquor in adding 3. when being warming up to 75 ℃ stirs, and is to place in the homogenizer under the condition of 0.09MPa to stir 20 minutes fast keeping vacuum pressure; Treat that temperature reduces to 30 ℃, add and promptly process ointment after the artificial Moschus stirs.)。
2.2 Therapeutic Method
Establish respectively: medicine 1 of the present invention adds upper limb body physical therapy symptomatic treatment group (I), medicine of the present invention 2 and adds upper limb body physical therapy symptomatic treatment group (II), traditional the lung-pulse ointment and add upper limb body physical therapy symptomatic treatment group (III), the lung-pulse ointment 1 and add that upper limb body physical therapy symptomatic treatment group (IV), the lung-pulse ointment 2 add upper limb body physical therapy symptomatic treatment group (V), the lung-pulse ointment 3 adds upper limb body physical therapy symptomatic treatment group (VI).Got medicine 1 of the present invention and 2 an amount of scouring trouble limbs 15～25 minutes, every day 2 times, 7 days was 1 course of treatment, and other each groups are smeared corresponding the lung-pulse ointment, be applied to the lung-pulse in right amount and follow capable position, and 2～3 times/day, observe the curative effect after four courses of treatment.
2.3 curative effect determinate standard
The evaluation of muscular tension is by international Ashworth standards of grading, and promptly 0 grade: muscular tension is normal; The I level: muscular tension slightly increases, and when getting involved the part passive flexion and extension, unexpected blocking do not appear in ROM, discharges then or minimum resistance occurs; The I+ level: muscular tension slightly increases, and during passive flexion and extension, behind ROM, occurs suddenly in 50% scope blocking, and when the ROM inspection is carried through to the end in continuation, little resistance is arranged all the time; The II level: muscular tension more obviously increases, and during through ROM most of, resistance all more significantly increases, but the part of getting involved still can more easily move; The III level: muscular tension seriously increases, and carries out the ROM inspection and has any problem; The IV level, stiff, the part of getting involved can not be bent and stretched.Cure: 0 grade of muscular tension; Produce effects: muscular tension decline two-stage or more than the two-stage; Effectively: muscular tension decline one-level; Invalid: muscular tension does not descend or raises.
3 results
The patient after 4 courses of treatment is treated in observation, and compares result such as table 1 with other group therapeutic effect.
Table 1 Drug therapy of the present invention to apoplexy after the change evaluation of patient's limbs muscular tension
Patient's muscular hypertonia was effective after data result showed the lung-pulse Ointment in Treatment apoplexy; And medicine of the present invention is cleaned cooperation limbs physical therapy treatment; Impel the medicine focus of going directly, add the limbs physical therapy with conventional dosage forms and the lung-pulse ointment 1, the lung-pulse ointment 2, the lung-pulse ointment 3 and compare, medicine 1 of the present invention adds the therapeutic effect that the limbs physical therapy all can improve medicine with medicine 2 of the present invention; Treatment reaches produce effects case showed increased, on the raising effective percentage, remarkable advantages is arranged.
Following embodiment all can realize above-mentioned experimental example effect
The specific embodiment
Embodiment 1: lotion of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, distilled water 850ml.
Method for preparing:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 10% of above-mentioned mixed material medicine total amount, boil 4 times, decocted 3 hours at every turn with 5 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.25-1.35 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the medicated powder that particle diameter is 0.1-1 μ m;
4. artificial Moschus's grinding is made to be uniformly dispersed, obtain b;
5. the concentrated solution a that 2. above-mentioned steps is obtained, the medicated powder that 3. step obtains, the b that 4. step obtains stirs, and filters, and adds distilled water and constantly stirring then at leisure, is filled into bottle, promptly makes lotion of the present invention.
Embodiment 2 lotions of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, distilled water 700ml.
Method for preparing:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 20% of above-mentioned mixed material medicine total amount, boil 3 times, decocted 1 hour at every turn with 15 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.35-1.45 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the superfine powder that particle diameter is 1-10 μ m;
4. the Moschus grinding is made to be uniformly dispersed, obtain b;
5. the concentrated solution a that 2. above-mentioned steps is obtained, the superfine powder that 3. step obtains, the b that 4. step obtains stirs, and filters, and adds distilled water and constantly stirring then at leisure, is filled into bottle, promptly makes lotion of the present invention.
Embodiment 3: lotion of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, distilled water 800ml.
Method for preparing:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 50% of above-mentioned mixed material medicine total amount, boil 1 time, decocted 1.5 hours at every turn with 20 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.15-1.25 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the superfine powder that particle diameter is 10-40 μ m;
4. artificial Moschus's grinding is made to be uniformly dispersed, obtain b;
5. the concentrated solution a that 2. above-mentioned steps is obtained, the superfine powder that 3. step obtains, the b that 4. step obtains stirs, and filters, and adds distilled water and constantly stirring then at leisure, is filled into bottle, promptly makes lotion of the present invention.
Embodiment 4: lotion of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, distilled water 250ml.
Method for preparing:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 60% of above-mentioned mixed material medicine total amount, boil 2 times, decocted 2.5 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the medicated powder that particle diameter is 40-60 μ m;
4. the Moschus grinding is made to be uniformly dispersed, obtain b;
5. the concentrated solution a that 2. above-mentioned steps is obtained, the medicated powder that 3. step obtains, the b that 4. step obtains stirs, and filters, and adds distilled water and constantly stirring then at leisure, is filled into bottle, promptly makes lotion of the present invention.
Embodiment 5: lotion of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, distilled water 500ml.
Method for preparing:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 90% of above-mentioned mixed material medicine total amount, boil 2 times, decocted 2.5 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.15-1.25 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the medicated powder that particle diameter is 60-90 μ m;
4. the Moschus grinding is made to be uniformly dispersed, obtain b;
5. the concentrated solution a that 2. above-mentioned steps is obtained, the medicated powder that 3. step obtains, the b that 4. step obtains stirs, and filters, and adds distilled water and constantly stirring then at leisure, is filled into bottle, promptly makes lotion of the present invention.
Embodiment 6: lotion of the present invention
Crude drug consists of:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, distilled water 4200ml.
Method for preparing:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing above-mentioned mixed material medicine, boil 3 times, decocted 2 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
4. artificial Moschus's grinding is made to be uniformly dispersed, obtain b;
4. the concentrated solution a that 2. above-mentioned steps is obtained, the b that 3. step obtains stir, and filter, and add distilled water and constantly stirring then at leisure, are filled into bottle, promptly make lotion of the present invention.
Embodiment 7: liniment of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, ethanol 110g, glycerol 45g, liquid paraffin 15g, azone 24g, distilled water 650ml.
Method for preparing:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 10% of above-mentioned mixed material medicine total amount, boil 4 times, decocted 3 hours at every turn with 5 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.25-1.35 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the superfine powder that particle diameter is 0.1-1 μ m;
4. artificial Moschus's grinding is made to be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol, liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the superfine powder that 3. step obtains; The b that 4. step obtains; Stir, filter, add distilled water and constantly stirring then at leisure; Be filled into bottle, promptly make liniment of the present invention.
Embodiment 8: liniment of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, ethanol 85g, glycerol 30g, liquid paraffin 12g, azone 15g, distilled water 550ml.
Method for preparing:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 20% of above-mentioned mixed material medicine total amount, boil 3 times, decocted 1 hour at every turn with 15 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.35-1.45 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the superfine powder that particle diameter is 1-10 μ m;
4. the Moschus grinding is made to be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol, liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the superfine powder that 3. step obtains; The b that 4. step obtains; Stir, filter, add distilled water and constantly stirring then at leisure; Be filled into bottle, promptly make liniment of the present invention.
Embodiment 9: liniment of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, ethanol 92g, glycerol 45g, liquid paraffin 18g, azone 25g, distilled water 250ml.
Method for preparing:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 50% of above-mentioned mixed material medicine total amount, boil 1 time, decocted 1.5 hours at every turn with 20 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.15-1.25 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the superfine powder that particle diameter is 10-40 μ m;
4. the artificial Moschus is added an amount of distilled water and grind to form fine powder, obtain b;
5. get glycerol and add azone, ethanol, liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the superfine powder that 3. step obtains; The b that 4. step obtains; Stir, filter, add distilled water and constantly stirring then at leisure; Be filled into bottle, promptly make liniment of the present invention.
Embodiment 10: liniment of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, ethanol 70g, glycerol 25g, liquid paraffin 7g, azone 12g, distilled water 120ml.
Method for preparing:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 60% of above-mentioned mixed material medicine total amount, boil 2 times, decocted 2.5 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the medicated powder that particle diameter is 40-60 μ m;
4. artificial Moschus's grinding is made to be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol, liquid paraffin, process clear and bright mixed solvent, add above-mentioned concentrated solution, residue mixed powder; At any time stir fast, add above-mentioned Moschus porphyrize liquid, stir; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment of the present invention.
Embodiment 11: liniment of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, alcohol 95 g, glycerol 30g, liquid paraffin 10g, azone 18g, distilled water 300ml.
Method for preparing:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 90% of above-mentioned mixed material medicine total amount, boil 2 times, decocted 2.5 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.15-1.25 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the medicated powder that particle diameter is 60-90 μ m;
4. the Moschus grinding is made to be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol, liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the medicated powder that 3. step obtains; The b that 4. step obtains; Stir, filter, add distilled water and constantly stirring then at leisure; Be filled into bottle, promptly make liniment of the present invention.
Embodiment 12: liniment of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, ethanol 300g, glycerol 145g, liquid paraffin 45g, azone 60g, distilled water 3400ml.
Method for preparing:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA remove impurity, clean system, mixing;
2. take by weighing above-mentioned hybrid medicine, 10 times of water of medicament gross weight, decocte with water 2 times; The each decoction 2.5 hours, collection, merge extractive liquid, and volatile oil, it is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density; And volatile oil joined in the concentrated solution, concentrated solution a;
3. artificial Moschus's grinding is made to be uniformly dispersed, obtain b;
4. get glycerol and add azone, ethanol, liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the b that 3. step obtains stir; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment of the present invention.
Embodiment 13: liniment of the present invention
Crude drug is formed:
Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, ethanol 300g, glycerol 200g, liquid paraffin 100g, azone 100g, distilled water 4200ml.
Method for preparing:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA remove impurity, clean system, mixing;
2. take by weighing above-mentioned hybrid medicine, 10 times of water of medicament gross weight, decocte with water 2 times; The each decoction 2.5 hours, collection, merge extractive liquid, and volatile oil, it is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density; And volatile oil joined in the concentrated solution, concentrated solution a;
3. artificial Moschus's grinding is made to be uniformly dispersed, obtain b;
4. get glycerol and add azone, ethanol, liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the b that 3. step obtains stir; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment of the present invention.
Claims (13)
1. a drug composition liniment or lotion of treating aortic arch syndrome, its crude drug consists of: Rhizoma Curcumae Longae 30-40 weight portion, Semen Myristicae 10-15 weight portion, Radix Et Rhizoma Nardostachyos 15-25 weight portion, Actinolitum 10-15 weight portion, Radix Glycyrrhizae 15-20 weight portion, artificial Moschus or Moschus 0.15-0.2 weight portion, Rhizoma Zingiberis 20-28 weight portion, Fructus cari carvi 28-35 weight portion, Rhizoma Acori Calami 15-20 weight portion, Pericarpium Zanthoxyli 10-15 weight portion, JIANHUA 15-20 weight portion; The adjuvant that it is characterized in that this liniment or lotion consists of:
Ethanol 15-300 weight portion, glycerol 10-200 weight portion, liquid paraffin 5-100 weight portion, azone 5-100 weight portion and distilled water 150-4200 parts by volume; Or distilled water 150-4200 parts by volume.
2. liniment as claimed in claim 1 or lotion is characterized in that the adjuvant of this liniment or lotion consists of:
Ethanol 150 weight portions, glycerol 100 weight portions, liquid paraffin 15 weight portions, azone 50 weight portions and distilled water 2200 parts by volume;
Or ethanol 20 weight portions, glycerol 190 weight portions, liquid paraffin 25 weight portions, azone 90 weight portions and distilled water 160 parts by volume;
Or ethanol 290 weight portions, glycerol 20 weight portions, liquid paraffin 6 weight portions, azone 10 weight portions and distilled water 4100 parts by volume;
Or ethanol 110 weight portions, glycerol 45 weight portions, liquid paraffin 15 weight portions, azone 24 weight portions and distilled water 650 parts by volume;
Or ethanol 85 weight portions, glycerol 30 weight portions, liquid paraffin 12 weight portions, azone 15 weight portions and distilled water 550 parts by volume;
Or ethanol 92 weight portions, glycerol 45 weight portions, liquid paraffin 18 weight portions, azone 25 weight portions and distilled water 250 parts by volume;
Or ethanol 70 weight portions, glycerol 25 weight portions, liquid paraffin 7 weight portions, azone 12 weight portions and distilled water 120 parts by volume;
Or alcohol 95 weight portion, glycerol 30 weight portions, liquid paraffin 10 weight portions, azone 18 weight portions and distilled water 300 parts by volume;
Or ethanol 300 weight portions, glycerol 145 weight portions, liquid paraffin 45 weight portions, azone 60 weight portions and distilled water 3400 parts by volume;
Or ethanol 300 weight portions, glycerol 200 weight portions, liquid paraffin 100 weight portions, azone 100 weight portions and distilled water 4200 parts by volume;
Or distilled water 2200 parts by volume; Or distilled water 500 parts by volume; Or distilled water 4200 parts by volume; Or distilled water 700 parts by volume; Or distilled water 850 parts by volume; Or distilled water 800 parts by volume; Or distilled water 150 parts by volume; Or distilled water 250 parts by volume; Or distilled water 3500 parts by volume.
3. like arbitrary described liniment of claim 1-2 or lotion, it is characterized in that the crude drug of this liniment or lotion consists of:
Rhizoma Curcumae Longae 36.3 weight portions, Semen Myristicae 12.1 weight portions, Radix Et Rhizoma Nardostachyos 19.4 weight portions, Actinolitum 12.1 weight portions, Radix Glycyrrhizae 17.0 weight portions, artificial Moschus or Moschus 0.17 weight portion, Rhizoma Zingiberis 24.2 weight portions, Fructus cari carvi 31.5 weight portions, Rhizoma Acori Calami 17.0 weight portions, Pericarpium Zanthoxyli 12.1 weight portions, JIANHUA 18.2 weight portions.
4. like the method for preparing of arbitrary described liniment of claim 1-3 or lotion, it is characterized in that this method comprises the steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing the 10%-100% of above-mentioned mixed material medicine total amount; Boil 1-4 time with 5-20 times of weight decocting; The each decoction 0.5-3 hour, collection, merge extractive liquid, and volatile oil, it is the concentrated solution of 1.0-1.5 that filtration and concentrated extracting solution become relative density; And volatile oil joined in the concentrated solution, concentrated solution a;
3. will remain mixed material medicated powder and be broken into the medicated powder that particle diameter is 0.1-150 μ m;
4. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the medicated powder that 3. step obtains; The b that 4. step obtains stirs mix homogeneously at any time fast; Filter; Add distilled water and constantly stirring at leisure, be filled into bottle, promptly make liniment; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the medicated powder that 3. step obtains, and the b that 4. step obtains stirs at any time fast, and mix homogeneously filters, and adds distilled water at leisure and constantly stirs, and is filled into bottle, promptly makes lotion.
5. the method for preparing of liniment as claimed in claim 4 or lotion is characterized in that this method comprises the steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 10% of above-mentioned mixed material medicine total amount, boil 4 times, decocted 3 hours at every turn with 5 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.25-1.35 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the superfine powder that particle diameter is 0.1-1 μ m;
4. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the superfine powder that 3. step obtains; The b that 4. step obtains stirs mix homogeneously at any time fast; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the medicated powder that 3. step obtains, and the b that 4. step obtains stirs at any time fast, and mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion.
6. the method for preparing of liniment as claimed in claim 4 or lotion is characterized in that this method comprises the steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 20% of above-mentioned mixed material medicine total amount, boil 3 times, decocted 1 hour at every turn with 15 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.35-1.45 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the superfine powder that particle diameter is 1-10 μ m;
4. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the superfine powder that 3. step obtains; The b that 4. step obtains stirs mix homogeneously at any time fast; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the medicated powder that 3. step obtains, and the b that 4. step obtains stirs at any time fast, and mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion.
7. the method for preparing of liniment as claimed in claim 4 or lotion is characterized in that this method comprises the steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 50% of above-mentioned mixed material medicine total amount, boil 1 time, decocted 1.5 hours at every turn with 20 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.15-1.25 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the superfine powder that particle diameter is 10-40 μ m;
4. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the superfine powder that 3. step obtains; The b that 4. step obtains stirs mix homogeneously at any time fast; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the medicated powder that 3. step obtains, and the b that 4. step obtains stirs at any time fast, and mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion.
8. the method for preparing of liniment as claimed in claim 4 or lotion is characterized in that this method comprises the steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 60% of above-mentioned mixed material medicine total amount, boil 2 times, decocted 2.5 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the medicated powder that particle diameter is 40-60 μ m;
4. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the medicated powder that 3. step obtains; The b that 4. step obtains stirs mix homogeneously at any time fast; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the medicated powder that 3. step obtains, and the b that 4. step obtains stirs at any time fast, and mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion.
9. the method for preparing of liniment as claimed in claim 4 or lotion is characterized in that this method comprises the steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 80% of above-mentioned mixed material medicine total amount, boil 3 times, decocted 1.5 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.25-1.35 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the medicated powder that particle diameter is 90-150 μ m;
4. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the medicated powder that 3. step obtains; The b that 4. step obtains stirs mix homogeneously at any time fast; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the medicated powder that 3. step obtains, and the b that 4. step obtains stirs at any time fast, and mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion.
10. the method for preparing of liniment as claimed in claim 4 or lotion is characterized in that this method comprises the steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing 90% of above-mentioned mixed material medicine total amount, boil 2 times, decocted 2.5 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.15-1.25 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. will remain mixed material medicated powder and be broken into the medicated powder that particle diameter is 60-90 μ m;
4. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
5. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the medicated powder that 3. step obtains; The b that 4. step obtains stirs mix homogeneously at any time fast; Filter; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the medicated powder that 3. step obtains, and the b that 4. step obtains stirs at any time fast, and mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion.
11. the method for preparing of liniment as claimed in claim 4 or lotion is characterized in that this method comprises the steps:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;
2. take by weighing above-mentioned mixed material medicine, boil 3 times, decocted 2 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;
3. artificial Moschus or Moschus are ground to make and be uniformly dispersed, obtain b;
4. get glycerol and add azone, ethanol and liquid paraffin, process clear and bright mixed solvent, the concentrated solution a that 2. the adding above-mentioned steps obtains, the b that 3. step obtains; At any time stir fast, mix homogeneously filters; Add distilled water and constantly stirring then at leisure, be filled into bottle, promptly make liniment; Or directly get the concentrated solution a that 2. above-mentioned steps obtain, the b that 3. step obtains, and stirring fast at any time, mix homogeneously filters, and adds distilled water then at leisure and constantly stirs, and is filled into bottle, promptly makes lotion.
12. be used for the application of the medicine of relaxing muscles and tendons and activating QI and blood in the collateral in preparation like the arbitrary described liniment of claim 1-2 or lotion.
13. liniment as claimed in claim 3 or lotion are used for the application of the medicine of relaxing muscles and tendons and activating QI and blood in the collateral in preparation.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1840154A (en) * | 2006-01-25 | 2006-10-04 | 甘肃奇正藏药有限公司 | Ointment for treating nervous damage and preparation method thereof |
| CN101181623A (en) * | 2007-11-17 | 2008-05-21 | 甘肃奇正藏药有限公司 | Method for preparing alcohol extraction of white vein ointment |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1840154A (en) * | 2006-01-25 | 2006-10-04 | 甘肃奇正藏药有限公司 | Ointment for treating nervous damage and preparation method thereof |
| CN101181623A (en) * | 2007-11-17 | 2008-05-21 | 甘肃奇正藏药有限公司 | Method for preparing alcohol extraction of white vein ointment |
Non-Patent Citations (1)
| Title |
|---|
| 韩秀琴.复方硫磺洗剂配制方法的改进.《实用医药杂志》.2008,第25卷(第1期),125. * |
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