CN101700385B

CN101700385B - Pharmaceutical composition medicinal liquor or tincture for curing white vein disease and preparation method thereof

Info

Publication number: CN101700385B
Application number: CN200910211266XA
Authority: CN
Inventors: 陈丽娟; 张国霞; 李波; 张樱山
Original assignee: Gansu Qizheng Tibetan Medicine Co Ltd
Current assignee: Gansu Qizheng Tibetan Medicine Co Ltd
Priority date: 2009-11-05
Filing date: 2009-11-05
Publication date: 2012-02-29
Anticipated expiration: 2029-11-05
Also published as: CN101700385A

Abstract

The invention discloses a pharmaceutical composition medicinal liquor or tincture for curing white vein disease and a preparation method thereof, and the invention is a medicinal liquor or tincture prepared by changing dosage form on the basis of prescription of traditional Tibetan medicine white vein ointment. The invention adopts an ultramicro preparation method which uses partial medicinal materials to extract partial medicinal materials, thus not only reserving effective components of medicinal materials, but also improving the content of crude drug components, increasing biological utilization degree and bettering the efficacy. The medicinal liquor or tincture in the invention has the advantages of rapid infiltration, endurable effect, obvious efficacy and the like, has simple and feasible preparation method, and is easy for industrialization and convenient in use; patients can accept easily and persist in treatment.

Description

A kind of pharmaceutical composition medicated wine of treating aortic arch syndrome or tincture and preparation method thereof

Invention field

The present invention relates to a kind of pharmaceutical composition medicated wine or tincture and preparation method thereof, particularly a kind of pharmaceutical composition medicated wine of treating aortic arch syndrome or tincture and preparation method thereof.

Technical background

The lung-pulse ointment is that the doctor among the people of Tibetan is carried according to " Tibetan medicine doctor certainly addendum releases difficulty ", the Four-Volume Medical Code two secretaries; In conjunction with the classical Tibetan medicine and pharmacology proved recipe that practical experience is formed, the lung-pulse ointment is former to be recorded in first 310 pages of " health drug standard promulgated by the ministries or commissions of the Central Government " 95 years version Tibetan medicines.The prescription of the lung-pulse ointment is:

Rhizoma Curcumae Longae 150g, Semen Myristicae 50g, Radix Et Rhizoma Nardostachyos 80g, Actinolitum 50g, Radix Glycyrrhizae 70g, artificial Moschus or Moschus 0.7g, Rhizoma Kaempferiae 100g, Fructus cari carvi 130g, Rhizoma Acori Calami 70g, Pericarpium Zanthoxyli 50g, JIANHUA 75g;

Method for making: above ten simply, and except that artificial Moschus or other porphyrize powder of Moschus, all the other are ground into fine powder altogether, sieve, and add artificial Moschus or Moschus fine powder facing-up, with butter and Adeps Sus domestica furnishing ointment, promptly get;

Function with cure mainly: relaxing muscles and tendons and activating QI and blood in the collateral.Be used for aortic arch syndrome, paralysis, hemiplegia, the muscle tendon is tetanic, meridians that wound causes and muscle tendon break wound, brothers' contraction urgency, limping etc.;

Theoretical according to the Tibetan medicine; Disorders of meridian is divided into the lung-pulse and Hei Mai, and wherein the lung-pulse is the venation that human body at first bears at embryo stage, also is the venation that fetal development obtains nutrition; These venations of birth back play again and absorb diet elite, conveying waste matter; To guarantee the normal circulation of three factors, seven materials,, can cause the generation of various diseases if the function of these venations gets muddled.The main pathogenic factor of aortic arch syndrome has following three aspects: aggravating activities, damage body venation; Pestilent toxicity pathogenic heat etc. is fallen in the arteries and veins; Mechanical damages such as weapons club cause rheumatism; In disorder and go into sering.The Tibetan medicine is the vital energy regualting and blood circulation-promoting collateral dredging to the regulation principle of aortic arch syndrome.Tibetan people is according to the Four-Volume Medical Code, " brilliant pearl book on Chinese herbal medicine " record; In conjunction with long-term practical experience, be the Tibetan medicine the lung-pulse ointment of raw material production with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Moschus, Fructus cari carvi, Pericarpium Zanthoxyli, JIANHUA, receive the trust of extensive patients with significant mass effect; But traditional Tibetan medicine the lung-pulse ointment preparation technology is modulated into ointment after all crude drug fine powders are mixed; Its technology is numerous and diverse, and batch production cycle is long, and production technology is unstable; Raw material and adjuvant source are unstable, are unfavorable for suitability for industrialized production; Part drug osmotic ability, bioavailability is low, can not guarantee curative effect fully, should not bring into play the curative effect of medicine; Product should not be deposited in addition, carries inconvenience; Because each side has greatly influenced the curative effect and the popularization of product.

Summary of the invention

It is pharmaceutical composition medicated wine or the tincture that basic square tube is crossed the treatment aortic arch syndrome that dosage changing form prepares that the object of the invention is to disclose a kind of prescription with traditional Tibetan medicine the lung-pulse ointment, and the object of the invention also is to disclose the method for preparing of this medicated wine or tincture.

The present invention seeks to realize through following technical scheme.

The crude drug of medicated wine of the present invention or tincture is formed and consumption is:

Rhizoma Curcumae Longae 30-40 weight portion, Semen Myristicae 10-15 weight portion, Radix Et Rhizoma Nardostachyos 15-25 weight portion, Actinolitum 10-15 weight portion, Radix Glycyrrhizae 15-20 weight portion, artificial Moschus or Moschus 0.15-0.2 weight portion, Rhizoma Zingiberis 20-28 weight portion, Fructus cari carvi 28-35 weight portion, Rhizoma Acori Calami 15-20 weight portion, Pericarpium Zanthoxyli 10-15 weight portion, JIANHUA 15-20 weight portion.

The crude drug of medicated wine of the present invention or tincture is formed and consumption is preferably:

Rhizoma Curcumae Longae 36.3 weight portions, Semen Myristicae 12.1 weight portions, Radix Et Rhizoma Nardostachyos 19.4 weight portions, Actinolitum 12.1 weight portions, Radix Glycyrrhizae 17.0 weight portions, artificial Moschus or Moschus 0.17 weight portion, Rhizoma Zingiberis 24.2 weight portions, Fructus cari carvi 31.5 weight portions, Rhizoma Acori Calami 17.0 weight portions, Pericarpium Zanthoxyli 12.1 weight portions, JIANHUA 18.2 weight portions.

The adjuvant of medicated wine of the present invention or tincture is formed and consumption is:

Edible distillate spirit or ethanol 200-5000 parts by volume.

The adjuvant of medicated wine of the present invention or tincture is formed and consumption is preferably:

Edible distillate spirit or ethanol 3000 parts by volume;

Or edible distillate spirit or ethanol 4800 parts by volume;

Or edible distillate spirit or ethanol 250 parts by volume;

Or edible distillate spirit or ethanol 1000 parts by volume;

Or edible distillate spirit or ethanol 2000 parts by volume;

Or edible distillate spirit or ethanol 4000 parts by volume;

Or edible distillate spirit or ethanol 800 parts by volume;

Or edible distillate spirit or ethanol 500 parts by volume.

The method for preparing of medicated wine of the present invention or tincture comprises the steps:

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

2. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA remove impurity, clean system, mixing;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mixing also is ground into coarse powder, and the edible distillate spirit of medicament gross weight 1-25 40-60% doubly or the soak with ethanol of 50-80% or percolation extract 1-5 time, needs 3-10 days during as if the employing immersion at every turn; Collect and merge extractive liquid; Add above-mentioned artificial Moschus or Moschus fine powder, stir, promptly get medicated wine of the present invention or tincture.

The method for preparing of medicated wine of the present invention or tincture preferably includes following steps:

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mix also to be ground into coarse powder, 50% edible distillate spirit of 5 times of medicament gross weights or 55% soak with ethanol or percolation extract 3 times, need 5 days if adopt when soaking at every turn; Collect and merge extractive liquid; Add above-mentioned artificial Moschus or Moschus fine powder, stir, promptly get medicated wine of the present invention or tincture.

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mix also to be ground into coarse powder, 45% edible distillate spirit of 15 times of medicament gross weights or 75% soak with ethanol or percolation extract 2 times, need 7 days if adopt when soaking at every turn; Collect and merge extractive liquid; Add above-mentioned artificial Moschus or Moschus fine powder, stir, promptly get medicated wine of the present invention or tincture.

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mix also to be ground into coarse powder, 55% edible distillate spirit of 20 times of medicament gross weights or 60% soak with ethanol or percolation extract 4 times, need 9 days if adopt when soaking at every turn; Collect and merge extractive liquid; Add above-mentioned artificial Moschus or Moschus fine powder, stir, promptly get medicated wine of the present invention or tincture.

The adjuvant of medicated wine of the present invention or tincture is formed can also add adsorbent on the basis of the above, and the consumption of adsorbent is:

Adsorbent: one or more in 0.5% kieselguhr 10-200 weight portion, active carbon 10-200 weight portion, silica gel 25-250 weight portion and the active hargil 25-250 weight portion.

The consumption that the adjuvant of medicated wine of the present invention or tincture is formed the adsorbent that can also add is preferably:

Adsorbent: one or more in 0.5% kieselguhr, 105 weight portions, active carbon 105 weight portions, silica gel 138 weight portions and active hargil 138 weight portions;

Or adsorbent: one or more in 0.5% kieselguhr, 15 weight portions, active carbon 195 weight portions, silica gel 30 weight portions and active hargil 245 weight portions;

Or adsorbent: one or more in 0.5% kieselguhr, 195 weight portions, active carbon 15 weight portions, silica gel 245 weight portions and active hargil 30 weight portions;

Or adsorbent: one or more in 0.5% kieselguhr, 195 weight portions, active carbon 105 weight portions, silica gel 245 weight portions and active hargil 105 weight portions.

The method for preparing of medicated wine of the present invention or tincture also comprises the steps:

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, the edible distillate spirit of medicament gross weight 1-25 40-60% doubly or the soak with ethanol of 50-80% or percolation extract 1-5 time; Need 3-10 days if adopt when soaking at every turn, and between soak period, add adsorbent, stir 1-3 every day; The semi-finished product that leave standstill are put in the freezing equipment, be cooled to-18 ℃-12 ℃ earlier, stop cooling; Temperature natural is gone up to 2 ℃-8 ℃, collect and merge extractive liquid,, add above-mentioned artificial Moschus or Moschus fine powder; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse is by the microporous filter membrane fine straining of 0.1% salt acid treatment, and encapsulation promptly gets medicated wine of the present invention or tincture then.

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 50% edible distillate spirit of 5 times of medicament gross weights or 60% soak with ethanol or percolation extract 3 times; Need 5 days if adopt when soaking at every turn, and between soak period, add adsorbent, stir every day 2 times; The semi-finished product that leave standstill are put in the freezing equipment, be cooled to-15 ℃ earlier, stop cooling; Temperature natural is gone up to 5 ℃, collect and merge extractive liquid,, add above-mentioned artificial Moschus or Moschus fine powder; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse is by the microporous filter membrane fine straining of 0.1% salt acid treatment, and encapsulation promptly gets medicated wine of the present invention or tincture then.

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 45% edible distillate spirit of 10 times of medicament gross weights or 75% soak with ethanol or percolation extract 5 times; Need 4 days if adopt when soaking at every turn, and between soak period, add adsorbent, stir every day 2 times; The semi-finished product that leave standstill are put in the freezing equipment, be cooled to-13 ℃ earlier, stop cooling; Temperature natural is gone up to 3 ℃, collect and merge extractive liquid,, add above-mentioned artificial Moschus or Moschus fine powder; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse is by the microporous filter membrane fine straining of 0.1% salt acid treatment, and encapsulation promptly gets medicated wine of the present invention or tincture then.

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 55% edible distillate spirit of 15 times of medicament gross weights or 70% soak with ethanol or percolation extract 2 times; Need 7 days if adopt when soaking at every turn, and between soak period, add adsorbent, stir every day 2 times; The semi-finished product that leave standstill are put in the freezing equipment, be cooled to-17 ℃ earlier, stop cooling; Temperature natural is gone up to 7 ℃, collect and merge extractive liquid,, add above-mentioned artificial Moschus or Moschus fine powder; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse is by the microporous filter membrane fine straining of 0.1% salt acid treatment, and encapsulation promptly gets medicated wine of the present invention or tincture then.

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 50% edible distillate spirit of 20 times of medicament gross weights or 55% soak with ethanol or percolation extract 1 time; Need 9 days if adopt when soaking at every turn, and between soak period, add adsorbent, stir every day 2 times; The semi-finished product that leave standstill are put in the freezing equipment, be cooled to-15 ℃ earlier, stop cooling; Temperature natural is gone up to 5 ℃, collect and merge extractive liquid,, add above-mentioned artificial Moschus or Moschus fine powder; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse is by the microporous filter membrane fine straining of 0.1% salt acid treatment, and encapsulation promptly gets medicated wine of the present invention or tincture then.

Medicated wine of the present invention or tincture are compared with prior art the lung-pulse ointment has following characteristics:

1, medicated wine of the present invention or tincture have advantages such as quick permeation, persistent, therapeutic effect be obvious.

2, method for preparing of the present invention is simple, is easy to industrialization.

3, medicated wine or the tincture processed of the inventive method is easy to use, and the patient is acceptant and can adhere to treatment.

Following experimental example and embodiment are used to further specify but are not limited to the present invention.

The pharmacological evaluation data of experimental example 1 medicated wine of the present invention and tincture

1 reagent, animal and instrument

1.1 reagent

The lung-pulse ointment (XiZang QiZheng Tibetan pharmaceuticals Co., Ltd provides) of conventional dosage forms;

The lung-pulse ointment 1 (method for preparing: 1. Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, JIANHUA 9g are made only, pulverize, mix homogeneously, subsequent use; 2. take by weighing 50% of mixed powder gross weight, volatile oil is collected in decocte with water 1 time simultaneously, and amount of water is 20 times of medical material gross weight, and 80 ℃ of temperature were fried in shallow oil 1.5 hours, collects decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.0 concentrated solution, and is subsequent use; 3. will remain medicated powder (50%) be ground into the medicated powder of 0.01 ~ 200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ subsequent use; 4. get the 100g lanoline; Gained mixed liquor in adding 3. when being warming up to 75 ℃ stirs, and is to place in the homogenizer under the condition of 0.09MPa to stir 20 minutes fast keeping vacuum pressure; Treat that temperature reduces to 30 ℃, add and promptly process ointment after the artificial Moschus stirs.)；

The lung-pulse ointment 2 (method for preparing: 1. Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, JIANHUA 9g are made only, pulverize, mix homogeneously, subsequent use; 2. take by weighing 50% of mixed powder gross weight, the alcohol reflux with 50% 1 time extracted 1.5 hours, and alcohol adding amount is 20 times of medical material gross weight, and 50 ℃ of temperature are collected extracting solution; Filter, be condensed into proportion and be 1.0 concentrated solution, subsequent use; 3. will remain medicated powder (50%) be ground into the medicated powder of 0.01 ~ 200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ subsequent use; 4. get the 100g lanoline; Gained mixed liquor in adding 3. when being warming up to 75 ℃ stirs, and is to place in the homogenizer under the condition of 0.09MPa to stir 20 minutes fast keeping vacuum pressure; Treat that temperature reduces to 30 ℃, add and promptly process ointment after the artificial Moschus stirs.)；

The lung-pulse ointment 3 (method for preparing: 1. Moschus is ground to form fine powder for 0.08 part; 2. with 20 parts in Rhizoma Curcumae Longae, 5 parts of Semen Myristicaes, 10 parts of Radix Et Rhizoma Nardostachyos, 5 parts of Actinolitum, 8 parts in Radix Glycyrrhizae,, 10 parts of 12 parts of Rhizoma Kaempferiaes, 15 parts of Fructus cari carvis, 8 parts of Rhizoma Acori Calamis, 7 parts in Pericarpium Zanthoxyli, JIANHUA pick totally, is ground into the superfine powder that particle diameter is 10 ~ 40 μ m; , 3. get step superfine powder 2. and place container for 20 parts, add 8 parts liquid paraffin therein, 8 parts glycerol; 9 parts of Tween-80s, 0.2 part of methyl hydroxybenzoate adds water to 100 parts, stirs system cream at 75 ~ 85 ℃; Add Moschus when waiting to be cooled to 35 ~ 40 ℃ and stir, process ointment, discharging; Room temperature was placed 3 ~ 8 hours, and the adding antiseptic is an amount of, and packing promptly gets.)；

Medicine 1 of the present invention (embodiment 7 is prepared from the description according to the present invention), medicine 2 of the present invention (embodiment 22 is prepared from the description according to the present invention), urethane etc.

1.2 instrument

Biological microscope.

1.3 animal

Kunming mouse, body weight 20 ± 2g, male.

2 methods and result

2.1 method

Get 70 of Kunming mouses; Be divided into 7 groups at random; Every group 10, establish the lung-pulse ointment group (II), the lung-pulse ointment 1 group of (III), the lung-pulse ointment 2 groups of (IV), the lung-pulse ointment 3 groups of (V), medicine of the present invention 1 group of (VI), 2 groups of medicines of the present invention (VII) of matched group (I), conventional dosage forms respectively.With barium sulfide the mouse back hair is sloughed before the experiment, smeared administration according to dosage back in the table 1.Matched group is smeared blank substrate liquid, the capillary vessel number in the anesthetized animal behind the last administration 30min, the same area of microscopic examination.

2.2 result

Adopt the SPSS11.5 deal with data; Variance analysis shows; Each group of matched group and other all has utmost point significant difference (P＜0.01); 1 group of the lung-pulse ointment group of conventional dosage forms and the lung-pulse ointment, 2 groups of the lung-pulse ointment, 3 groups of the lung-pulse ointment, 1 group of medicine of the present invention, medicine of the present invention all have utmost point significant difference (P＜0.01) for 2 groups; Do not have significant difference between 3 groups three groups of 1 group of the lung-pulse ointment, 2 groups of the lung-pulse ointment, the lung-pulse ointment, but 2 groups utmost point significant difference (P＜0.01) is arranged all, do not have significant difference between 2 groups of 1 group of medicine of the present invention and the medicines of the present invention with 1 group of medicine of the present invention, medicine of the present invention.The lung-pulse ointment group and 1 group of the lung-pulse ointment, 2 groups of the lung-pulse ointment, 3 groups of the lung-pulse ointment, 1 group of medicine of the present invention, medicine of the present invention that conventional dosage forms is described all can improve the animal blood circulation for 2 groups; 1 group of the lung-pulse ointment; 2 groups of the lung-pulse ointment, 3 groups of three groups of action effect difference of the lung-pulse ointment are little, but all are superior to the lung-pulse ointment group (P＜0.01) of conventional dosage forms, the action effect no difference of science of statistics of 1 group of medicine of the present invention, 2 groups of medicines of the present invention; But all be superior to other each groups (P＜0.01), result such as table 1.

Table 1 medicated wine of the present invention, tincture are to the microcirculatory influence of Mice Auricle blood vessel

(compare △ P＜0.05, △ △ P＜0.01 with the I group; Compare * P＜0.05, * * P＜0.01 with the II group; Compare ★ P＜0.05, ★ ★ P＜0.01 with the VII group)

Following embodiment all can realize the described effect of above-mentioned experimental example

The specific embodiment

Embodiment 1: medicated wine of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 50% edible distillate spirit 1000ml;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA remove impurity, clean system, mix;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mixing also is ground into coarse powder, and 50% edible distillate spirit that the medicament gross weight is 5 times soaks 3 times, each 5 days; Collect and merge extractive liquid; Add above-mentioned artificial Moschus's fine powder, stir, promptly get medicated wine of the present invention.

Embodiment 2: medicated wine of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 55% edible distillate spirit 3000ml.

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mixing also is ground into coarse powder, and 55% edible distillate spirit that the medicament gross weight is 15 times soaks 2 times, each 7 days; Collect and merge extractive liquid; Add above-mentioned artificial Moschus's fine powder, stir, promptly get medicated wine of the present invention.

Embodiment 3: medicated wine of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 60% edible distillate spirit 250ml;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mixing also is ground into coarse powder, and 60% edible distillate spirit that the medicament gross weight is 1.25 times soaks 5 times, each 5 days; Collect and merge extractive liquid; Add above-mentioned artificial Moschus's fine powder, stir, promptly get medicated wine of the present invention.

Embodiment 4: medicated wine of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 45% edible distillate spirit 2000ml;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mixing also is ground into coarse powder; The 45% edible distillate spirit percolation that the medicament gross weight is 10 times extracts 5 times, collects and merge extractive liquid,, adds above-mentioned artificial Moschus's fine powder; Stir, promptly get medicated wine of the present invention.

Embodiment 5: medicated wine of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 50% edible distillate spirit 4000ml;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mixing also is ground into coarse powder; The 50% edible distillate spirit percolation that the medicament gross weight is 20 times extracts 1 time, collects and merge extractive liquid,, adds above-mentioned artificial Moschus's fine powder; Stir, promptly get medicated wine of the present invention.

Embodiment 6: medicated wine of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 50% edible distillate spirit 500ml;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mixing also is ground into coarse powder; The 50% edible distillate spirit percolation that the medicament gross weight is 2.5 times extracts 3 times, collects and merge extractive liquid,, adds above-mentioned artificial Moschus's fine powder; Stir, promptly get medicated wine of the present invention.

Embodiment 7: medicated wine of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 40% edible distillate spirit 2000ml, 0.5% kieselguhr 105g, active carbon 105g, silica gel 138g, active hargil 138g;

Method for preparing:

1. Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 40% edible distillate spirit that the medicament gross weight is 10 times soaks 5 times, each 3 days; And between soak period, add 0.5% kieselguhr, active carbon, silica gel and active hargil, and stir every day 2 times, the semi-finished product that leave standstill are put in the freezing equipment, make temperature reduce to one 13 ℃; Stop cooling, let temperature natural go up, collect and merge extractive liquid,, add above-mentioned Moschus fine powder to 3 ℃; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse microporous filter membrane (the salt acid treatment with 0.1%) fine straining, encapsulation promptly gets medicated wine of the present invention.

Embodiment 8: medicated wine of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 50% edible distillate spirit 500ml, 0.5% kieselguhr 15g, active carbon 35g, silica gel 15g, active hargil 30g;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 50% edible distillate spirit that the medicament gross weight is 2.5 times soaks 4 times, each 5 days; And between soak period, add 0.5% kieselguhr, active carbon, silica gel and active hargil, and stir every day 2 times, the semi-finished product that leave standstill are put in the freezing equipment, make temperature reduce to one 13 ℃; Stop cooling, let temperature natural go up, collect and merge extractive liquid,, add above-mentioned Moschus fine powder to 3 ℃; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse microporous filter membrane (the salt acid treatment with 0.1%) fine straining, encapsulation promptly gets medicated wine of the present invention.

Embodiment 9: medicated wine of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 50% edible distillate spirit 4000ml, 0.5% kieselguhr 15g, active carbon 195g, silica gel 30g, active hargil 245g;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 50% edible distillate spirit that the medicament gross weight is 20 times soaks 1 time; Each 10 days, and between soak period, add 0.5% kieselguhr, active carbon, silica gel and active hargil, stir every day 2 times; The semi-finished product that leave standstill are put in the freezing equipment, made temperature reduce to one 15 ℃, stop cooling; Let temperature natural go up, collect and merge extractive liquid,, add above-mentioned artificial Moschus's fine powder to 5 ℃; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse microporous filter membrane (the salt acid treatment with 0.1%) fine straining, encapsulation promptly gets medicated wine of the present invention.

Embodiment 10: medicated wine of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 50% edible distillate spirit 800ml, 0.5% kieselguhr 20g, active carbon 45g;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 50% edible distillate spirit that the medicament gross weight is 4 times soaks 5 times, each 3 days; And between soak period, add 0.5% kieselguhr and active carbon, and stir every day 2 times, the semi-finished product that leave standstill are put in the freezing equipment, make temperature reduce to one 13 ℃; Stop cooling, let temperature natural go up, collect and merge extractive liquid,, add above-mentioned Moschus fine powder to 3 ℃; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse microporous filter membrane (the salt acid treatment with 0.1%) fine straining, encapsulation promptly gets medicated wine of the present invention.

Embodiment 11: medicated wine of the present invention

Crude drug is formed:

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, the 50% edible distillate spirit percolation that the medicament gross weight is 5 times extracts 3 times; The semi-finished product that leave standstill are put in the freezing equipment, made temperature reduce to one 15 ℃, stop cooling; Let temperature natural go up, collect and merge extractive liquid,, add above-mentioned artificial Moschus's fine powder to 5 ℃; Stir, earlier with suitable filter coarse filtration, reuse microporous filter membrane (salt acid treatment) fine straining with 0.1%; The storage of shady and cool lucifuge place is put in encapsulation, promptly gets medicated wine of the present invention.

Embodiment 12: medicated wine of the present invention

Crude drug is formed:

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, the 60% edible distillate spirit percolation that the medicament gross weight is 1.25 times extracts 5 times; The semi-finished product that leave standstill are put in the freezing equipment, made temperature reduce to one 15 ℃, stop cooling; Let temperature natural go up, collect and merge extractive liquid,, add above-mentioned artificial Moschus's fine powder to 5 ℃; Stir, earlier with suitable filter coarse filtration, reuse microporous filter membrane (salt acid treatment) fine straining with 0.1%; The storage of shady and cool lucifuge place is put in encapsulation, promptly gets medicated wine of the present invention.

Embodiment 13: medicated wine of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 55% edible distillate spirit 3000ml;

Method for preparing:

1. Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, the 55% edible distillate spirit percolation that the medicament gross weight is 15 times extracts 2 times; The semi-finished product that leave standstill are put in the freezing equipment, made temperature reduce to one 17 ℃, stop cooling; Let temperature natural go up, collect and merge extractive liquid,, add above-mentioned Moschus fine powder to 7 ℃; Stir, earlier with suitable filter coarse filtration, reuse microporous filter membrane (salt acid treatment) fine straining with 0.1%; Encapsulation promptly gets medicated wine of the present invention.

Embodiment 14: medicated wine of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 40% edible distillate spirit 4800ml;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, the 40% edible distillate spirit percolation that the medicament gross weight is 24 times extracts 2 times; The semi-finished product that leave standstill are put in the freezing equipment, made temperature reduce to one 15 ℃, stop cooling; Let temperature natural go up, collect and merge extractive liquid,, add above-mentioned artificial Moschus's fine powder to 5 ℃; Stir, earlier with suitable filter coarse filtration, reuse microporous filter membrane (salt acid treatment) fine straining with 0.1%; The storage of shady and cool lucifuge place is put in encapsulation, promptly gets medicated wine of the present invention.

Embodiment 15: tincture of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 75% ethanol 2000ml;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mixing also is ground into coarse powder, 75% soak with ethanol that the medicament gross weight is 10 times 5 times, each 4 days; Collect and merge extractive liquid; Add above-mentioned Moschus fine powder, stir, process tincture of the present invention.

Embodiment 16: tincture of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 80% ethanol 500ml;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mixing also is ground into coarse powder, 80% soak with ethanol that the medicament gross weight is 2.5 times 3 times, each 3 days; Collect and merge extractive liquid; Add above-mentioned Moschus fine powder, stir, process tincture of the present invention.

Embodiment 17: tincture of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 55% ethanol 4000ml;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mixing also is ground into coarse powder, 55% soak with ethanol that the medicament gross weight is 20 times 1 time, each 9 days; Collect and merge extractive liquid; Add above-mentioned Moschus fine powder, stir, process tincture of the present invention.

Embodiment 18: tincture of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 70% ethanol 3000ml;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mixing also is ground into coarse powder; 70% ethanol percolate extraction that the medicament gross weight is 15 times 2 times is collected and merge extractive liquid,, adds above-mentioned Moschus fine powder; Stir, process tincture of the present invention.

Embodiment 19: tincture of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 80% ethanol 250ml;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mixing also is ground into coarse powder; 80% ethanol percolate extraction that the medicament gross weight is 1.25 times 2 times is collected and merge extractive liquid,, adds above-mentioned Moschus fine powder; Stir, process tincture of the present invention.

Embodiment 20: tincture of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 60% ethanol 1000ml, 0.5% kieselguhr 195g, active carbon 15g, silica gel 245g, active hargil 30g;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 60% soak with ethanol that the medicament gross weight is 5 times 3 times, each 5 days; And between soak period, add 0.5% kieselguhr, active carbon, silica gel and active hargil, and stir every day 2 times, the semi-finished product that leave standstill are put in the freezing equipment, make temperature reduce to one 17 ℃; Stop cooling, let temperature natural go up, collect and merge extractive liquid,, add above-mentioned artificial Moschus's fine powder to 7 ℃; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse microporous filter membrane (the salt acid treatment with 0.1%) fine straining, encapsulation promptly gets tincture of the present invention.

Embodiment 21: tincture of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 80% ethanol 250ml, 0.5% kieselguhr 15g, active carbon 30g, silica gel 30g, active hargil 35g;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 80% soak with ethanol that the medicament gross weight is 1.25 times 7 times, each 3 days; And between soak period, add 0.5% kieselguhr, active carbon, silica gel and active hargil, and stir every day 2 times, the semi-finished product that leave standstill are put in the freezing equipment, make temperature reduce to one 15 ℃; Stop cooling, let temperature natural go up, collect and merge extractive liquid,, add above-mentioned artificial Moschus's fine powder to 5 ℃; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse microporous filter membrane (the salt acid treatment with 0.1%) fine straining, encapsulation promptly gets tincture of the present invention.

Embodiment 22: tincture of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 70% ethanol 3000ml, 0.5% kieselguhr 105g, active carbon 105g, silica gel 138g, active hargil 138g;

Method for preparing:

1. Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 70% soak with ethanol that the medicament gross weight is 15 times 2 times, each 7 days; And between soak period, add 0.5% kieselguhr, active carbon, silica gel and active hargil, and stir every day 2 times, the semi-finished product that leave standstill are put in the freezing equipment; Make temperature reduce to one 15 ℃, stop cooling, let temperature natural go up to 5 ℃; Collect and merge extractive liquid,, add above-mentioned Moschus fine powder, stir; Remove slag, earlier with suitable filter coarse filtration, reuse microporous filter membrane (salt acid treatment) fine straining with 0.1%; The storage of shady and cool lucifuge place is put in encapsulation, promptly gets tincture of the present invention.

Embodiment 23: tincture of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 50% ethanol 800ml, silica gel 30g, active hargil 50g;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 50% soak with ethanol that the medicament gross weight is 4 times 5 times, each 5 days; And between soak period, add silica gel and active hargil, and stir every day 2 times, the semi-finished product that leave standstill are put in the freezing equipment, make temperature reduce to one 15 ℃; Stop cooling, let temperature natural go up, collect and merge extractive liquid,, add above-mentioned artificial Moschus's fine powder to 5 ℃; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse microporous filter membrane (the salt acid treatment with 0.1%) fine straining, encapsulation promptly gets tincture of the present invention.

Embodiment 24: tincture of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 60% ethanol 4800ml, 0.5% kieselguhr 195g, active carbon 105g, silica gel 245g, active hargil 105g;

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 60% soak with ethanol that the medicament gross weight is 24 times 2 times, each 7 days; And between soak period, add 0.5% kieselguhr, active carbon, silica gel and active hargil, and stir every day 2 times, the semi-finished product that leave standstill are put in the freezing equipment, make temperature reduce to-17 ℃; Stop cooling, let temperature natural go up, collect and merge extractive liquid,, add above-mentioned artificial Moschus's fine powder to 7 ℃; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse microporous filter membrane (the salt acid treatment with 0.1%) fine straining, encapsulation promptly gets tincture of the present invention.

Embodiment 25: tincture of the present invention

Crude drug is formed:

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 75% ethanol percolate extraction that the medicament gross weight is 10 times 5 times; The semi-finished product that leave standstill are put in the freezing equipment, made temperature reduce to-15 ℃, stop cooling; Let temperature natural go up, collect and merge extractive liquid,, add above-mentioned artificial Moschus's fine powder to 5 ℃; Stir, earlier with suitable filter coarse filtration, reuse microporous filter membrane (salt acid treatment) fine straining with 0.1%; Encapsulation promptly gets tincture of the present invention.

Embodiment 26: tincture of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, 55% ethanol 4000ml;

Method for preparing:

1. Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 55% ethanol percolate extraction that the medicament gross weight is 20 times 1 time; The semi-finished product that leave standstill are put in the freezing equipment, made temperature reduce to-15 ℃, stop cooling; Let temperature natural go up, collect and merge extractive liquid,, add above-mentioned Moschus fine powder to 5 ℃; Stir, earlier with suitable filter coarse filtration, reuse microporous filter membrane (salt acid treatment) fine straining with 0.1%; Encapsulation promptly gets tincture of the present invention.

Embodiment 27: tincture of the present invention

Crude drug is formed:

Method for preparing:

1. the artificial Moschus is ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 80% ethanol percolate extraction that the medicament gross weight is 2.5 times 9 times; The semi-finished product that leave standstill are put in the freezing equipment, made temperature reduce to-15 ℃, stop cooling; Let temperature natural go up, collect and merge extractive liquid,, add above-mentioned artificial Moschus's fine powder to 5 ℃; Stir, earlier with suitable filter coarse filtration, reuse microporous filter membrane (salt acid treatment) fine straining with 0.1%; Encapsulation promptly gets tincture of the present invention.

Claims

1. a pharmaceutical composition medicated wine or tincture of treating aortic arch syndrome, its crude drug consists of: Rhizoma Curcumae Longae 30-40 weight portion, Semen Myristicae 10-15 weight portion, Radix Et Rhizoma Nardostachyos 15-25 weight portion, Actinolitum 10-15 weight portion, Radix Glycyrrhizae 15-20 weight portion, artificial Moschus or Moschus 0.15-0.2 weight portion, Rhizoma Zingiberis 20-28 weight portion, Fructus cari carvi 28-35 weight portion, Rhizoma Acori Calami 15-20 weight portion, Pericarpium Zanthoxyli 10-15 weight portion, JIANHUA 15-20 weight portion; The adjuvant that it is characterized in that this medicated wine or tincture consists of:

40-60% edible distillate spirit or 50-80% ethanol 200-5000 parts by volume.

2. medicated wine as claimed in claim 1 or tincture is characterized in that the crude drug of this medicated wine wherein or tincture consists of:

3. according to claim 1 or claim 2 medicated wine or tincture is characterized in that the adjuvant of this medicated wine or tincture consists of:

40-60% edible distillate spirit or 50-80% ethanol 3000 parts by volume;

Or 40-60% edible distillate spirit or 50-80% ethanol 4800 parts by volume;

Or 40-60% edible distillate spirit or 50-80% ethanol 250 parts by volume;

Or 40-60% edible distillate spirit or 50-80% ethanol 1000 parts by volume;

Or 40-60% edible distillate spirit or 50-80% ethanol 2000 parts by volume;

Or 40-60% edible distillate spirit or 50-80% ethanol 4000 parts by volume;

Or 40-60% edible distillate spirit or 50-80% ethanol 800 parts by volume;

Or 40-60% edible distillate spirit or 50-80% ethanol 500 parts by volume.

4. like arbitrary described medicated wine of claim 1-3 or tincture, it is characterized in that the adjuvant composition of this medicated wine or tincture also adds following additives:

5. medicated wine as claimed in claim 4 or tincture is characterized in that the additives that add in the adjuvant composition of this medicated wine or tincture are:

6. like the method for preparing of arbitrary described medicated wine of claim 1-3 or tincture, it is characterized in that this method comprises the steps:

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mixing also is ground into coarse powder, and the edible distillate spirit of medicament gross weight 1-25 40-60% doubly or the soak with ethanol of 50-80% or percolation extract 1-5 time, needs 3-10 days during as if the employing immersion at every turn; Collect and merge extractive liquid; Add above-mentioned artificial Moschus or Moschus fine powder, stir, promptly get medicated wine or tincture.

7. the method for preparing of medicated wine as claimed in claim 6 or tincture is characterized in that this method comprises the steps:

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mix also to be ground into coarse powder, 50% edible distillate spirit of 5 times of medicament gross weights or 55% soak with ethanol or percolation extract 3 times, need 5 days if adopt when soaking at every turn; Collect and merge extractive liquid; Add above-mentioned artificial Moschus or Moschus fine powder, stir, promptly get medicated wine or tincture.

8. the method for preparing of medicated wine as claimed in claim 6 or tincture is characterized in that this method comprises the steps:

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mix also to be ground into coarse powder, 45% edible distillate spirit of 15 times of medicament gross weights or 75% soak with ethanol or percolation extract 2 times, need 7 days if adopt when soaking at every turn; Collect and merge extractive liquid; Add above-mentioned artificial Moschus or Moschus fine powder, stir, promptly get medicated wine or tincture.

9. the method for preparing of medicated wine as claimed in claim 6 or tincture is characterized in that this method comprises the steps:

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material; Mix also to be ground into coarse powder, 55% edible distillate spirit of 20 times of medicament gross weights or 60% soak with ethanol or percolation extract 4 times, need 9 days if adopt when soaking at every turn; Collect and merge extractive liquid; Add above-mentioned artificial Moschus or Moschus fine powder, stir, promptly get medicated wine or tincture.

10. like the method for preparing of claim 4 or 5 described medicated wine or tincture, it is characterized in that this method comprises the steps:

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, the edible distillate spirit of medicament gross weight 1-25 40-60% doubly or the soak with ethanol of 50-80% or percolation extract 1-5 time; Need 3-10 days if adopt when soaking at every turn, and between soak period, add adsorbent, stir 1-3 every day; The semi-finished product that leave standstill are put in the freezing equipment, be cooled to-18 ℃-12 ℃ earlier, stop cooling; Temperature natural is gone up to 2 ℃-8 ℃, collect and merge extractive liquid,, add above-mentioned artificial Moschus or Moschus fine powder; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse is by the microporous filter membrane fine straining of 0.1% salt acid treatment, and encapsulation promptly gets medicated wine or tincture then.

11. the method for preparing of medicated wine as claimed in claim 10 or tincture is characterized in that this method comprises the steps:

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 50% edible distillate spirit of 5 times of medicament gross weights or 60% soak with ethanol or percolation extract 3 times; Need 5 days if adopt when soaking at every turn, and between soak period, add adsorbent, stir every day 2 times; The semi-finished product that leave standstill are put in the freezing equipment, be cooled to-15 ℃ earlier, stop cooling; Temperature natural is gone up to 5 ℃, collect and merge extractive liquid,, add above-mentioned artificial Moschus or Moschus fine powder; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse is by the microporous filter membrane fine straining of 0.1% salt acid treatment, and encapsulation promptly gets medicated wine or tincture then.

12. the method for preparing of medicated wine as claimed in claim 10 or tincture is characterized in that this method comprises the steps:

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 45% edible distillate spirit of 10 times of medicament gross weights or 75% soak with ethanol or percolation extract 5 times; Need 4 days if adopt when soaking at every turn, and between soak period, add adsorbent, stir every day 2 times; The semi-finished product that leave standstill are put in the freezing equipment, be cooled to-13 ℃ earlier, stop cooling; Temperature natural is gone up to 3 ℃, collect and merge extractive liquid,, add above-mentioned artificial Moschus or Moschus fine powder; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse is by the microporous filter membrane fine straining of 0.1% salt acid treatment, and encapsulation promptly gets medicated wine or tincture then.

13. the method for preparing of medicated wine as claimed in claim 10 or tincture is characterized in that this method comprises the steps:

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 55% edible distillate spirit of 15 times of medicament gross weights or 70% soak with ethanol or percolation extract 2 times; Need 7 days if adopt when soaking at every turn, and between soak period, add adsorbent, stir every day 2 times; The semi-finished product that leave standstill are put in the freezing equipment, be cooled to-17 ℃ earlier, stop cooling; Temperature natural is gone up to 7 ℃, collect and merge extractive liquid,, add above-mentioned artificial Moschus or Moschus fine powder; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse is by the microporous filter membrane fine straining of 0.1% salt acid treatment, and encapsulation promptly gets medicated wine or tincture then.

14. the method for preparing of medicated wine as claimed in claim 10 or tincture is characterized in that this method comprises the steps:

1. artificial Moschus or Moschus are ground to make and be uniformly dispersed;

3. take by weighing Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, JIANHUA medical material, mix and be ground into coarse powder, 50% edible distillate spirit of 20 times of medicament gross weights or 55% soak with ethanol or percolation extract 1 time; Need 9 days if adopt when soaking at every turn, and between soak period, add adsorbent, stir every day 2 times; The semi-finished product that leave standstill are put in the freezing equipment, be cooled to-15 ℃ earlier, stop cooling; Temperature natural is gone up to 5 ℃, collect and merge extractive liquid,, add above-mentioned artificial Moschus or Moschus fine powder; Stir, remove slag, earlier with suitable filter coarse filtration; Reuse is by the microporous filter membrane fine straining of 0.1% salt acid treatment, and encapsulation promptly gets medicated wine or tincture then.

15. be used for the application of the medicine of relaxing muscles and tendons and activating QI and blood in the collateral in preparation like the arbitrary described medicated wine of claim 1-5 or tincture.