CN103340891A - B vitamins containing composition and preparation method thereof - Google Patents
B vitamins containing composition and preparation method thereof Download PDFInfo
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- CN103340891A CN103340891A CN201310229828XA CN201310229828A CN103340891A CN 103340891 A CN103340891 A CN 103340891A CN 201310229828X A CN201310229828X A CN 201310229828XA CN 201310229828 A CN201310229828 A CN 201310229828A CN 103340891 A CN103340891 A CN 103340891A
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- folic acid
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Abstract
The invention relates to a B vitamins containing composition and a preparation method thereof. The composition comprises the following active components: vitamin B1, vitamin B2, nicotinamide, vitamin B6, pantothenic acid, folic acid and vitamin 12. The composition provided by the invention avoids the disadvantage of excess or insufficient B vitamins content in the conventional products.
Description
Technical field
The present invention relates to contain the compositions of vitamin, be specifically related to a kind of composition and method of making the same that contains vitamin B group.
Background technology
Vitamin B group is to keep the indispensable water soluble vitamins of the normal function of human body and metabolic activity, comprises vitamin B
1, vitamin B
2, nicotiamide, pantothenic acid, vitamin B
6, folic acid, vitamin B
12Deng.Human body can't be made synthetic vitamin B group voluntarily, must additionally replenish.If lack vitamin B, cell function reduces at once, causes dysbolismus etc.
Vitamin B
1Claim thiamine or aneurine again, by pyrimidine ring and thiazole ring be combined into.Vitamin B
1Can blood circulation promoting, the auxiliary salt processed with acid is made and blood flow forms, and helps the brain function performance, energy metabolism, growth, appetite, learning capacity is all played a part positive, and can help human body opposing aging and tobacco and wine to the adverse effect of human body.
Vitamin B
2Being riboflavin again, is erythrocyte formation, antibody manufacturing, cellular respiration and the necessary a kind of vitamin of growing.Can easing eyes fatigue, prevention cataract, the metabolism of auxiliary saccharide, fat, protein.
Nicotiamide (vitamin B
3) be nadide and coenzyme II ingredient, become the coenzyme of many dehydrogenases.Be used for to supplement the nutrients and treatment glossitis, dermatitis, help nervous tissue to exercise the normal physiological function, participate in saccharide, fat, protein-based metabolism and the manufacturing of hydrochloric acid, participate in the synthetic of bile and gastric juice gonadal hormone, but cholesterol reducing improves blood circulation.
Pantothenic acid (vitamin B
5) be the important composition element of coenzyme, participate in the manufacturing of adrenal hormone and the formation of antibody, assist the conversion of the utilization of other vitamin and saccharide, fat, protein energy, prevent anemia, keep the digestive tract normal function.
Vitamin B
6Be a kind of vitamin B group that contains pyridoxol or 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine. or pyridoxamine, can assist to keep sodium-potassium balance in the health, promote erythrocytic formation, enhancing human body immunity power, prevent arteriosclerosis, stop the formation of renal calculus, the cell enlargement of control DNA and hereditary materials such as division, RNA synthetic etc.
Folic acid (vitamin B
9) be cell division, the indispensable vitamin of growing, organizing that all growth promoter or metabolism are vigorous needs that all enough folic acid supplies are arranged.Under-supply, the regeneration of cell is just hindered, and causes megaloblastic anemia; In addition, can cause that also undergrowth, hair become ash, tongue inflammation, gastrointestinal upset, intelligence degeneration.The anemia of pregnant woman lacks folic acid can cause premature labor, miscarriage and neonate low birth weight.Conceived early stage shortage folic acid is the main cause that causes the fetal neural tube deformity.In addition, folic acid can also slow down the generation of senile dementia.
Vitamin B
12Be cobalamine again, the major physiological function is to participate in making the bone marrow erythrocyte, prevents pernicious anemia, prevents that cerebral nerve is damaged.
Existing a lot of about the patent of vitamin B group:
CN201120437605.9 discloses a kind of soft capsule that comprises multiple vitamin B group, its content comprise vitamin B
1, vitamin B
2, vitamin B
6, vitamin B
12, nicotiamide, folic acid, calcium pantothenate, suspending agent, vegetable oil, its concrete consumption is vitamin B
11-3 part, vitamin B
21-3 part, vitamin B
60.5-1.5 part, vitamin B
120.0001-0.005 part, nicotiamide 2-6 part, folic acid 0.1-0.07 part, calcium pantothenate 1-3 part, suspending agent 2-8 part, vegetable oil 70-90 part.The content of this invention nicotiamide, folic acid, pantothenic acid is lower, the amount of pantothenic acid especially, and it is daily required to satisfy the normal person.
CN200910086276.5 discloses a kind of prevention and treatment hyperhomocysteinemiainjury or the pharmaceutical composition of the disease that raises with homocysteine, and its composition comprises folic acid, vitamin B
6, vitamin B
12, vitamin B
1, vitamin B
2, in vitamin PP, biotin and the pantothenic acid one or more.
CN200810106518.8 discloses the compositions that is formed by one or more derivative of vitamin B group and other kind vitamin, wherein the preferred compositions mode is, the compositions that any one or multivitamin B family's derivant and any one or multivitamin B family original shape composition form.Be used for prophylactic treatment vitamin B and the various diseases that causes improves immunity of organisms for want of.
CN200610051041.9 discloses a kind of composite vitamin pharmaceutical formulation, and it is by vitamin B
120-60mg, vitamin B
23-10mg, vitamin B
65-20mg, vitamin B
380-300mg, vitamin B
122-8 μ g, vitamin B
55-20mg and vitamin C 100-400mg and suitable auxiliary material excipient are made.
The soup minister doubly is good for the vitamin B complex sheet by vitamin B
1, vitamin B
2, vitamin B
6, vitamin B
12, nicotiamide, calcium pantothenate, biotin, folic acid, calcium carbonate, corn starch, dextrin, magnesium stearate form, wherein every contains: vitamin B
11.23mg, vitamin B
21.25mg, vitamin B
61.25mg, vitamin B
121.87 μ g, nicotinic acid 8.28mg, pantothenic acid 3.09mg, biotin 19.25 μ g, folic acid 187 μ g, calcium 75.9mg.
Kind unit hall vitamin B complex soft capsule, its primary raw material is: vitamin B
1, vitamin B
2, vitamin B
6, vitamin B
12, folic acid, nicotiamide, calcium pantothenate, soybean oil, Cera Flava, gelatin, glycerol, water, titanium dioxide, carmine, Cacao pigment, every contains: vitamin B
110mg, vitamin B
210mg, vitamin B
64mg, vitamin B
124.5 μ g, folic acid 200 μ g, nicotiamide 20mg, pantothenic acid 10mg.This product is health product, wherein B
1, B
2, B
6Consumption is higher, and excessive B
1With B
2May have side effects to human body.
Existing its composition proportion of product about vitamin B group has nothing in common with each other, and people can be according to the different choice product of individual to every kind of vitamin B group demand, to satisfy people to the needs of vitamin B group.In addition, the tablet of existing vitamin B group product is colored sheet more, and irregular colour is even, and the content of per unit preparation is also inhomogeneous.
Summary of the invention
The purpose of this invention is to provide a kind of compositions that contains vitamin B group.
The invention provides a kind of compositions that contains vitamin B group, said composition contains following active component: vitamin B
1, vitamin B
2, nicotiamide, vitamin B
6, pantothenic acid, folic acid, vitamin B
12
Concrete, active component composition and content are respectively in the said composition per unit preparation: vitamin B
10.96-1.92mg, vitamin B
20.96-1.92mg, nicotiamide 5.28-10.56mg, vitamin B
60.96-1.92mg, pantothenic acid 4-8mg, folic acid 0.1-0.24mg, vitamin B
122-6 μ g.
Preferably, active component composition and content are respectively in the said composition per unit preparation:
Vitamin B
11.0-1.8mg, vitamin B
21.0-1.8mg, nicotiamide 5.5-7.92mg, vitamin B
61-1.8mg, pantothenic acid 4.5-7.5mg, folic acid 0.12-0.21mg, vitamin B
123-5 μ g.
In the above-mentioned composition:
Described vitamin B
1Provided by thiamine hydrochloride.
Described vitamin B
2Provided by riboflavin.
Described pantothenic acid is vitamin B
5, provided by the D-calcium pantothenate.
Described vitamin B
6Provided by pyridoxine hydrochloride.
Described vitamin B
12Provided by cyanocobalamin.
The present invention also provides the preparation that contains above-mentioned composition, and described preparation is made up of said composition and pharmaceutically acceptable carrier.
Described preparation is tablet or capsule.
Described pharmaceutically acceptable carrier is filler, binding agent, fluidizer.
Concrete, described tablet contains the composition of following weight portion: the fluidizer of the filler of the compositions of 5-7 part, 79-87 part, the binding agent of 6-12 part and 0.5-3.5 part.
Also can contain coating materials in the described tablet, the consumption of described coating materials is the heavy 1-3% of sheet.
In the above-mentioned tablet:
Described filler is dextrin, microcrystalline Cellulose, starch;
Described binding agent is hypromellose E5, hypromellose E15, carboxymethyl starch sodium, hydroxypropyl cellulose or starch;
Described fluidizer is magnesium stearate, silicon dioxide, lactose.
The present invention also provides the preparation method of above-mentioned tablet, and this method may further comprise the steps:
1) preparation of vitamin B group mixed powder: get vitamin B
1, vitamin B
2, nicotiamide, D-calcium pantothenate, vitamin B
6, folic acid, vitamin B
12Cross the 80-120 mesh sieve respectively.Claim the dextrin of total amount 16-20%, the microcrystalline Cellulose of 43-50%, standby; With vitamin B
1, vitamin B
2, vitamin B
6Press equivalent incremental method mixing with the dextrin of equivalent, cross the 80-120 mesh sieve, make A and doubly loose; With folic acid, vitamin B
12Press equivalent incremental method mixing with the microcrystalline Cellulose of equivalent, cross the 80-120 mesh sieve, make B and doubly loose; Nicotiamide, D-calcium pantothenate by equivalent incremental method mixing, are crossed the 80-120 mesh sieve, make C and doubly loose; Then A is doubly loose, B doubly looses and C doubly looses mixing, and then add the microcrystalline Cellulose of equivalent, mixing namely gets the vitamin B group mixed powder;
2) premix: after the starch of 13-23% and remaining microcrystalline Cellulose crossed the 80-120 mesh sieve respectively, mixing, standby;
3) granulate: the binding agent of 6-12% is prepared into the binder solution that concentration is 5-10%, adds mixed powder and the step 2 of step 1) then) the premix powder, granulate, dry granulate is then with 0.5-3.3% fluidizer, the granule mixing for preparing, tabletting.
Also comprise coating steps in the said method behind tabletting, the coating materials that described coating uses is the transparent coating agent.
In the said method:
Described concentration is 5-10% hypromellose E5, and wherein the concentration of 5-10% refers to 100g purified water dissolving 5-10g hypromellose E5.
The invention provides a kind of compositions and preparation thereof that contains vitamin B group has the following advantages:
1, compositions consumption
1) in the compositions that contains vitamin B group provided by the invention, vitamin B
1, vitamin B
2, nicotiamide, vitamin B
6, pantothenic acid, folic acid, vitamin B
12Weight ratio be 0.96-1.92:0.96-1.92:5.28-10.56:0.96-1.92:4-8:0.1-0.24:0. 002-0.006, each composition proportion is reasonable, using dosage satisfies needed by human body, and soup minister B in the strong sheet doubly
12Low excessively with the amount of pantothenic acid.B in the kind unit hall vitamin B complex soft capsule
1, B
2, B
6Consumption is higher, and excessive B
1With B
2May have side effects to human body;
2) in the compositions provided by the invention, the consumption of pantothenic acid and folic acid is more than the consumption in the existing product more than 2 times, and within the scope that human body can absorb, can fully assist the conversion of the utilization of other vitamin B group and saccharide, fat, protein energy, guarantee that growth promoter and metabolism are required.
2, preparation:
1) among the preparation technology of vitamin B group composition tablet provided by the invention, use the 80-120 order to sieve, loose powder is thinner, and material can evenly mix, and guarantees that every content is uniform and stable;
2) preparation A doubly looses earlier in the technology of the present invention, B doubly looses and C doubly looses, because the consumption of every kind of vitamin is less, therefore adopts the equivalent incremental method (such as 4.5g B
1, B
2, B
6Mix with the 4.5g dextrin, more mixed 9g material mixed with the 9g dextrin again) carry out mixing of materials, vitamin B among the present invention
1, vitamin B
2, vitamin B
6The raw material use amount suitable, folic acid and vitamin B
12Quite, nicotiamide is suitable with the D-calcium pantothenate, therefore adopts the mode of this mixing, can make mixing of materials more even.
3) the present invention uses the granulation of 20-24 order nylon mesh, granulate, and granule is thinner, guarantees that the content of per unit preparation is even, unilateral color even, attractive in appearance, and glossy;
4) the present invention uses hypromellose E5, hypromellose E15, hydroxypropyl cellulose, carboxymethyl starch sodium or starch to prepare binding agent, magnesium stearate, silicon dioxide, lactose, as fluidizer, the tablet of preparation is complete bright and clean, color and luster is even, suitable hardness is arranged, and easy disintegrating.
In sum, compositions provided by the invention has been avoided the shortcoming excessive or in shortage of existing product.Preparation technology of the present invention can guarantee that every content is even, and complete bright and clean, color and luster is even, and suitable hardness is arranged, and easy disintegrating, has solved the shortcoming of existing product flower sheet.
The specific embodiment
Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Described vitamin B
1Provided by thiamine hydrochloride, thiamine hydrochloride contains the vitamin B of 98.5%-101.5%
1, its manufacturer is Huazhong Pharmaceutical Co., Ltd..
Described vitamin B
2Riboflavin (the vitamin B that contains 98%-102% is provided by riboflavin
2), its manufacturer is Guanji, Hubei Pharmaceutical limited company.
Described pantothenic acid is vitamin B
5, provided by the D-calcium pantothenate, D-calcium pantothenate (amount 97% that contains pantothenic acid), its manufacturer is New Development pharmaceutcal corporation, Ltd.
Described vitamin B
6Provided by pyridoxine hydrochloride, pyridoxine hydrochloride contains the vitamin B of 98%-100.5%
6, its manufacturer is Huazhong Pharmaceutical Co., Ltd..
Folic acid, content are 10% folic acid, and its manufacturer is Ji, Hebei weighing apparatus (group) pharmaceutcal corporation, Ltd.
Described vitamin B
12Provided by cyanocobalamin, contain 1% B
12, its manufacturer is Hebei beautiful star biological engineering company limited.
Above-mentioned source should not be construed as limiting the invention just for the source property of its raw material is described.
Embodiment 1:B vitamin tablet (1000)
1, raw material and each active component such as following table:
2, preparation method
1) preparation of vitamin B group mixed powder: get vitamin B
1, vitamin B
2, nicotiamide, D-calcium pantothenate, vitamin B
6, folic acid, vitamin B
12It is standby to cross 100 mesh sieves respectively;
With vitamin B
1, vitamin B
2, vitamin B
6Mix by the equivalent incremental method with the 50g dextrin and to cross 100 mesh sieves after 5 minutes, make A and doubly loose; (illustrate: the equivalent incremental method is the 3.69g vitamin B
1, vitamin B
2, vitamin B
6Mix with the 3.69g dextrin, 7.38g mixed powder afterwards mixes with the 7.38g dextrin again, obtains the 14.76g mixed powder and mixes with the 14.76g dextrin, obtains the 29.52g mixed powder and mixes with remaining 25.83g dextrin.Down together)
With folic acid, vitamin B
12Mixed 10 minutes by the equivalent incremental method with the 50g microcrystalline Cellulose, cross 100 mesh sieves, make B and doubly loose;
Nicotiamide, D-calcium pantothenate were mixed 5 minutes by the equivalent incremental method, cross 100 mesh sieves, make C and doubly loose;
With A doubly loose, B doubly looses and C doubly looses mixed 5 minutes earlier, adds the 50g microcrystalline Cellulose again, remixes 10 minutes, gets the vitamin B group mixed powder.
2) premix: after starch, 50g microcrystalline Cellulose crossed 100 mesh sieves respectively, mixed 20 minutes.
3) granulate: in advance 30g hypromellose E5 being prepared concentration with 300g water is 5% hypromellose E5,5% hypromellose E5 is added in the mixed powder, stir 10min, granulate with 24 order nylon mesh, be about 3.0% being dried to moisture under 80 ℃, with 24 order nylon mesh granulate.
4) total mixing: the 1.5g magnesium stearate was mixed tabletting, coating 20 minutes with granule behind vitamin B group premix material and the granulate.
3, specification: 0.3g/ sheet.
Embodiment 2:B vitamin sheet (1000)
1, raw material and each active component such as following table:
2, preparation method:
1) preparation of vitamin B group mixed powder: get vitamin B
1, vitamin B
2, nicotiamide, D-calcium pantothenate, vitamin B
6, folic acid, vitamin B
12It is standby to cross 80 mesh sieves respectively;
With vitamin B
1, vitamin B
2, vitamin B
6Mix by the equivalent incremental method with the 50g dextrin and to cross 80 mesh sieves after 5 minutes, make A and doubly loose;
With folic acid, vitamin B
12Mixed 10 minutes by the equivalent incremental method with the 50g microcrystalline Cellulose, cross 80 mesh sieves, make B and doubly loose;
Nicotiamide, D-calcium pantothenate were mixed 5 minutes by the equivalent incremental method, cross 80 mesh sieves, make C and doubly loose;
With A doubly loose, B doubly looses and C doubly looses mixed 5 minutes earlier, adds the 50g microcrystalline Cellulose again, remixes 10 minutes, gets the vitamin B group mixed powder.
2) premix: after 42.04g starch, 50g microcrystalline Cellulose crossed 80 mesh sieves respectively, mixed 20 minutes.
3) granulate: getting 35g starch, to prepare concentration with 350g water be 10% starch slurry, 10% starch slurry added in the mixed powder stirring 10min.Granulating with 20 order nylon mesh, is about 3.0% being dried to moisture under 75 ℃, with 20 order nylon mesh granulate.
4) total mixing: 2.5g silicon dioxide was mixed 20 minutes with granule behind vitamin B group premix material and the granulate, press the average weight tabletting of 0.3g, coating.
3, specification: 0.3g/ sheet.
Embodiment 3:B vitamin sheet (1000)
1, raw material and each active component such as following table:
2, preparation technology:
1) preparation of vitamin B group mixed powder:
Get vitamin B
1, vitamin B
2, nicotiamide, D-calcium pantothenate, vitamin B
6, folic acid, vitamin B
12It is standby to cross 120 mesh sieves respectively;
With vitamin B
1, vitamin B
2, vitamin B
6Mix by the equivalent incremental method with the 50g dextrin and to cross 120 mesh sieves after 5 minutes, make A and doubly loose;
With folic acid, vitamin B
12Mixed 10 minutes by the equivalent incremental method with the 50g microcrystalline Cellulose, cross 120 mesh sieves, make B and doubly loose;
Nicotiamide, D-calcium pantothenate were mixed 5 minutes by the equivalent incremental method, cross 120 mesh sieves, make C and doubly loose;
With A doubly loose, B doubly looses and C doubly looses mixed 5 minutes earlier, adds the 50g microcrystalline Cellulose again, remixes 10 minutes, gets the vitamin B group mixed powder.
2) premix: after 38.92g starch, 50g microcrystalline Cellulose crossed 120 mesh sieves respectively, mixed 20 minutes.
3) granulate: it is 10% hydroxypropyl cellulose that 30g hypromellose E15 is prepared concentration with 300g water, 10% hydroxypropyl cellulose is added in the mixed powder, stir 10min, granulate with 20 order nylon mesh, be about 3.0% being dried to moisture under 85 ℃, with 20 order nylon mesh granulate.
4) total mixing: lactose was mixed 20 minutes with granule behind vitamin B group premix material and the granulate, press the average weight tabletting of 0.3g, coating.
3, specification: 0.3g/ sheet.
Embodiment 4:B vitamin sheet (1000)
1, raw material and each active component such as following table:
2, preparation technology:
1) preparation of vitamin B group mixed powder: get vitamin B
1, vitamin B
2, nicotiamide, D-calcium pantothenate, vitamin B
6, folic acid, vitamin B
12It is standby to cross 120 mesh sieves respectively;
With vitamin B
1, vitamin B
2, vitamin B
6Mix by the equivalent incremental method with the 60g dextrin and to cross 120 mesh sieves after 5 minutes, make A and doubly loose;
With folic acid, vitamin B
12Mixed 10 minutes by the equivalent incremental method with the 50g microcrystalline Cellulose, cross 120 mesh sieves, make B and doubly loose;
Nicotiamide, D-calcium pantothenate were mixed 5 minutes by the equivalent incremental method, cross 120 mesh sieves, make C and doubly loose;
With A doubly loose, B doubly looses and C doubly looses mixed 5 minutes earlier, adds the 50g microcrystalline Cellulose again, remixes 10 minutes, gets the vitamin B group mixed powder.
2) premix: after 70.14g starch, 30g microcrystalline Cellulose crossed 120 mesh sieves respectively, mixed 20 minutes.
3) granulate: it is 5% carboxymethyl starch sodium that 20g hypromellose E15 is prepared into concentration with 400g water, 5% carboxymethyl starch sodium is added in the mixed powder, stir 10min, granulate with 24 order nylon mesh, be about 3.0% being dried to moisture under 75 ℃, with 24 order nylon mesh granulate.
4) total mixing: the 1.5g magnesium stearate was mixed 20 minutes with granule behind vitamin B group premix material and the granulate, press the average weight tabletting of 0.3g, coating.
3, specification: 0.3g/ sheet.
Embodiment 5:B vitamin tablet (1000)
1, raw material and each active component such as following table:
2, preparation technology:
1) preparation of vitamin B group mixed powder: get vitamin B
1, vitamin B
2, nicotiamide, D-calcium pantothenate, vitamin B
6, folic acid, vitamin B
12It is standby to cross 100 mesh sieves respectively;
With vitamin B
1, vitamin B
2, vitamin B
6Mix by the equivalent incremental method with the 50g dextrin and to cross 100 mesh sieves after 5 minutes, make A and doubly loose;
With folic acid, vitamin B
12Mixed 10 minutes by the equivalent incremental method with the 50g microcrystalline Cellulose, cross 100 mesh sieves, make B and doubly loose;
Nicotiamide, D-calcium pantothenate were mixed 5 minutes by the equivalent incremental method, cross 100 mesh sieves, make C and doubly loose;
With A doubly loose, B doubly looses and C doubly looses mixed 5 minutes earlier, adds the 50g microcrystalline Cellulose again, remixes 10 minutes, gets the vitamin B group mixed powder.
2) premix: after 54.62g starch, 40g microcrystalline Cellulose crossed 100 mesh sieves respectively, mixed 20 minutes.
3) granulate: it is 10% hypromellose E15 that 30g hypromellose E15 is prepared concentration with 100g water, 10% hypromellose E15 is added in the mixed powder, stir 10min, granulate with 20 order nylon mesh, be about 3.0% being dried to moisture under 80 ℃, with 20 order nylon mesh granulate.
4) total mixing: the 5g hydroxymethyl starch was mixed 20 minutes with granule behind vitamin B group premix material and the granulate, press the average weight tabletting of 0.3g, coating.
3, specification: 0.3g/ sheet.
Experimental example 1: detect
The compositions that embodiment 1-5 is provided detects, and concrete detection method is:
Be numbered GB/T4789.3-2010 according to standard, standard name is that the method in the food safety national standard microbiological Test escherichia coli counting is measured the coli-group number;
Be numbered GB/T4789.4 according to standard, standard name is that the food safety national standard food microbiological analysis Salmonella method of inspection is measured Salmonella;
Be numbered GB/T4789.5 according to standard, standard name is that the food safety national standard food microbiological analysis shigella method of inspection is measured shigella;
Be numbered GB4789.10-2010 according to standard, standard name is measured staphylococcus aureus for the method in the check of food microbiological analysis staphylococcus aureus;
Be numbered GB/T4789.11 according to standard, standard name is measured Hemolytic streptococcus for the method for microbiological test of food hygiene Hemolytic streptococcus check;
Be numbered GB/T4789.15-2010 according to standard, standard name is that the method in food safety national standard microbiological Test mycete and the yeast counting is measured mycete and yeast count;
Be numbered GB/T5009.197 according to standard, standard name is that the method in the mensuration of thiamine hydrochloride pyridoxine hydrochloride nicotinic acid nicotiamide and caffeine in the health food is measured vitamin B
1Amount with nicotiamide;
Be numbered GB/T5009.85 according to standard, standard name is that vitamin B is measured in the method for measuring of riboflavin in the food
2Amount;
Be numbered GB/T5009.210 according to standard, standard name is the amount that the method in the mensuration of pantothenic acid in the food is measured pantothenic acid;
Be numbered GB/T5009.154 according to standard, standard name is vitamin B in the food
6Mensuration in method measure vitamin B
6Amount;
Be numbered GB/T5009.211 according to standard, standard name is the amount that the method in the mensuration of folic acid in the food is measured folic acid;
Be numbered GB/T5413.14 according to standard, standard name is vitamin B in infant food and the milk
12Mensuration in method measure vitamin B
12Amount;
Be numbered GB/T5009.4 according to standard, standard name is that the method in the mensuration of ash in the food is measured ash;
Be numbered GB/T5009.11 according to standard, standard name is that the method in the mensuration of total arsenic and inorganic arsenic in the food is measured arsenic content;
Be numbered GB/T5009.12 according to standard, standard name is that the method in the mensuration plumbous in the food is measured lead tolerance.
The testing result of embodiment 1-5 sees Table 1:
Table 1: embodiment 1-5B vitamin compositions physical and chemical index
Table 1 is the result show, the equal conformance with standard requirement of every physical and chemical index of embodiment 1-5 preparation, and the character of tablet is complete bright and clean, and color and luster is even, does not have the phenomenon of flower sheet.
Though, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. compositions that contains vitamin B group, said composition contains following active component: vitamin B
1, vitamin B
2, nicotiamide, vitamin B
6, pantothenic acid, folic acid, vitamin B
12
2. compositions according to claim 1 is characterized in that, active component composition and content are respectively in the said composition per unit preparation: vitamin B
10.96-1.92mg, vitamin B
20.96-1.92mg, nicotiamide 5.28-10.56mg, vitamin B
60.96-1.92mg, pantothenic acid 4-8mg, folic acid 0.1-0.24mg, vitamin B
122-6 μ g.
3. compositions according to claim 1 is characterized in that, active component composition and content are respectively in the said composition per unit preparation: vitamin B
11.0-1.8mg, vitamin B
21.0-1.8mg, nicotiamide 5.5-7.92mg, vitamin B
61-1.8mg, pantothenic acid 4.5-7.5mg, folic acid 0.12-0.21mg, vitamin B
123-5 μ g.
4. according to each described compositions of claim 1-3, it is characterized in that described pantothenic acid is vitamin B
5, provided by calcium pantothenate.
5. contain the preparation that right requires each described compositions of 1-4, it is characterized in that described preparation is made up of said composition and pharmaceutically acceptable carrier.
6. preparation according to claim 5 is characterized in that, described preparation is tablet or capsule.
7. preparation according to claim 6 is characterized in that, described tablet contains the composition of following weight portion: the fluidizer of the filler of the compositions of 5-7 part, 79-87 part, the binding agent of 6-12 part and 0.5-3.5 part.
8. preparation according to claim 7 is characterized in that, described filler is dextrin, microcrystalline Cellulose, starch; Described fluidizer is magnesium stearate, silicon dioxide, lactose.
9. preparation according to claim 7 is characterized in that, described binding agent is hypromellose E5, hypromellose E15, carboxymethyl starch sodium, hydroxypropyl cellulose or starch.
10. a method for preparing each described preparation of claim 7-9 is characterized in that, this method may further comprise the steps:
1) preparation of vitamin B group mixed powder: get vitamin B
1, vitamin B
2, nicotiamide, D-calcium pantothenate, vitamin B
6, folic acid, vitamin B
12Cross the 80-120 mesh sieve respectively.Claim the dextrin of total amount 16-20%, the microcrystalline Cellulose of 43-50%, standby; With vitamin B
1, vitamin B
2, vitamin B
6Press equivalent incremental method mixing with the dextrin of equivalent, cross the 80-120 mesh sieve, make A and doubly loose; With folic acid, vitamin B
12Press equivalent incremental method mixing with the microcrystalline Cellulose of equivalent, cross the 80-120 mesh sieve, make B and doubly loose; Nicotiamide, D-calcium pantothenate by equivalent incremental method mixing, are crossed the 80-120 mesh sieve, make C and doubly loose; Then A is doubly loose, B doubly looses and C doubly looses mixing, and then add the microcrystalline Cellulose of equivalent, mixing namely gets the vitamin B group mixed powder;
2) premix: after the starch of 13-23% and remaining microcrystalline Cellulose crossed the 80-120 mesh sieve respectively, mixing, standby;
3) granulate: the binding agent of 6-12% is prepared into the binder solution that concentration is 5-10%, adds mixed powder and the step 2 of step 1) then) the premix powder, granulate, dry granulate is then with 0.5-3.3% fluidizer, the granule mixing for preparing, tabletting.
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| CN105168221A (en) * | 2015-10-14 | 2015-12-23 | 康普药业股份有限公司 | Medicine composition for treating beriberi |
| CN105962379A (en) * | 2016-05-03 | 2016-09-28 | 宣城柏维力生物工程有限公司 | Vitamin B tablets and preparation method thereof |
| CN107969704A (en) * | 2017-12-07 | 2018-05-01 | 山东禹王制药有限公司 | A kind of vitamin premix of suitable soft capsule preparation and preparation method thereof |
| CN111249245A (en) * | 2020-03-24 | 2020-06-09 | 上海峰林生物科技有限公司 | Vitamin B2Quick release tablet and preparation method thereof |
| CN111419816A (en) * | 2020-04-28 | 2020-07-17 | 广东润源中天生物科技有限公司 | Vitamin B tablets and production method thereof |
| CN113498862A (en) * | 2021-08-27 | 2021-10-15 | 上海英库商务咨询有限公司 | Diet formula capable of preventing beriberi, herpes and corner inflammation and losing weight |
| CN114617901A (en) * | 2022-03-11 | 2022-06-14 | 陕西必康制药集团控股有限公司 | Composition for preventing and treating diseases caused by B vitamins and vitamin C deficiency and preparation method thereof |
| CN115515574A (en) * | 2020-03-11 | 2022-12-23 | 博士伦爱尔兰有限公司 | Compositions and methods comprising high concentrations of vitamins for use in age-related eye diseases |
| CN117256861A (en) * | 2023-10-12 | 2023-12-22 | 广东润智源健康科技有限公司 | Multi-effect vitamin B nutrition tablet and preparation method thereof |
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| CN105168221A (en) * | 2015-10-14 | 2015-12-23 | 康普药业股份有限公司 | Medicine composition for treating beriberi |
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| CN105962379B (en) * | 2016-05-03 | 2020-01-14 | 宣城柏维力生物工程有限公司 | Vitamin B tablets and preparation method thereof |
| CN107969704A (en) * | 2017-12-07 | 2018-05-01 | 山东禹王制药有限公司 | A kind of vitamin premix of suitable soft capsule preparation and preparation method thereof |
| CN115515574A (en) * | 2020-03-11 | 2022-12-23 | 博士伦爱尔兰有限公司 | Compositions and methods comprising high concentrations of vitamins for use in age-related eye diseases |
| CN111249245A (en) * | 2020-03-24 | 2020-06-09 | 上海峰林生物科技有限公司 | Vitamin B2Quick release tablet and preparation method thereof |
| CN111419816A (en) * | 2020-04-28 | 2020-07-17 | 广东润源中天生物科技有限公司 | Vitamin B tablets and production method thereof |
| CN113498862A (en) * | 2021-08-27 | 2021-10-15 | 上海英库商务咨询有限公司 | Diet formula capable of preventing beriberi, herpes and corner inflammation and losing weight |
| CN114617901A (en) * | 2022-03-11 | 2022-06-14 | 陕西必康制药集团控股有限公司 | Composition for preventing and treating diseases caused by B vitamins and vitamin C deficiency and preparation method thereof |
| CN117256861A (en) * | 2023-10-12 | 2023-12-22 | 广东润智源健康科技有限公司 | Multi-effect vitamin B nutrition tablet and preparation method thereof |
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Application publication date: 20131009 |