CN103478412A - Microencapsulated multi-vitamin premix and preparation method thereof - Google Patents
Microencapsulated multi-vitamin premix and preparation method thereof Download PDFInfo
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- CN103478412A CN103478412A CN201310426324.7A CN201310426324A CN103478412A CN 103478412 A CN103478412 A CN 103478412A CN 201310426324 A CN201310426324 A CN 201310426324A CN 103478412 A CN103478412 A CN 103478412A
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Abstract
The invention relates to a type of microencapsulated multi-vitamin premix and a preparation method of the microencapsulated multi-vitamin premix and mainly relates to the field of agricultural biotechnologies and feed additives. The preparation method of the microencapsulated multi-vitamin premix is used for improving the uniformity of the multi-vitamin premix and the stability of multiple vitamins. According to the formula of the microencapsulated multi-vitamin premix, the microencapsulated multi-vitamin premix contains PEG, vitamin A, vitamin D3, vitamin E, vitamin K3 (MNB), vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, biotin, nicotinamide and calcium pantothenate. The preparation method includes the three steps of PEG fusion, homogenous emulsification and spraying condensation and is simple in process and easy to operate. The multi-vitamin premix produced with the preparation method is actually an interstitial solid solution, the vitamins are evenly distributed in the form of microcrystals or amorphous powder, the grading phenomenon is avoided in the transportation process, and the multi-vitamin premix is good in stability and thus can not be damaged easily in the storage and feed processing processes. In comparison with multi-vitamin premix produced with a traditional direct mixing method, the addition amount of the microencapsulated multi-vitamin premix prepared with the method in mixed feed can be reduced by 35-50%, and the production performance level of animals will not be affected.
Description
Technical field
The present invention is a kind of preparation method of microencapsulation complex vitamin premix, is mainly used in improving the uniformity of complex vitamin premix and the stability of various vitamins, relates generally to agricultural biotechnologies and feed additive field.
Background technology
Vitamin is to maintain the animal eubolism, grow and produce the low molecular nutrition material of a necessary class, and in feed cost, the accounting example is very little, but plays very important effect.Vitamin participates in absorption, utilization and the deposition of various nutriments with the pattern of coenzyme, there is no vitamin, animal will be restricted the utilization of energy, albumen etc., because the content of vitamin in the animal and fowl fodder raw material is extremely low, utilizability is poor, essential extra supplementing, just can reach and promote production performance, prevention hypovitaminosis, improves the purposes such as premunition and anti-stress level.Vitamin not only kind is many, and the requirement of livestock and poultry is atomic, directly adds and easily produces error, and optimal arbitrary way is to use complex vitamin premix.
The main method of producing at present complex vitamin premix is that various powdery vitamin raw materials are directly mixed with carriers such as corn flour, powdered rice hulls, maize cob meals, there is following problem in the complex vitamin premix that this method is produced: (1) mixture homogeneity is undesirable, even adopt state-of-the-art mixing plant, also can only guarantee that the mixture homogeneity coefficient of variation is less than 5%, from the different samples of same batch products, there is some difference for vitamin content; (2) the quality of complex vitamin premix product is subject to the impact of the physicochemical properties such as carrier moisture, granularity, unit weight, mobility, pH value to a great extent; (3) the classification phenomenon easily occurs in the complex vitamin premix that mixed method is produced in transportation; (4) vitamin is to temperature, pressure, metal ion, oxidant sensitivity, and the vitamin in the complex vitamin premix that mixed method is produced is attached to carrier surface, in naked state, easily in feed processing and storage process, wrecks.
In recent years, in order to improve the quality of complex vitamin premix, the researcher is from selection and the pretreatment of carrier both at home and abroad, the each side such as improvement of production equipment and production technology are carried out large quantity research, because these researchs fail to break away from the thoughtcast of " powder mixing ", although obtained certain effect, failed fundamentally to solve mixture homogeneity and stability problem.
Even, the stable dispersion that solution is comprised of many kinds of substance, if can adopt the method for similar obtain solution in the vitamin premix production process, just can fundamentally solve the problem that existing production method exists, prepare uniform and stable complex vitamin premix of new generation.
Polyethylene glycol (PEG) fusing point low (50-63 ℃), heating energy is melted into liquid, meets coldly can condense into solid again, still can keep this specific character after adding a certain amount of other compositions.Due to the PEG stable chemical nature, there is good compatibility with organic matter,, but studied always and applied at feedstuff industry through being commonly used for the matrix of dripping pill, suppository, tablet at pharmaceutical industry.
Summary of the invention
In order to overcome the shortcoming of direct mixed method, we adopt the solid solution preparation technique to invent a kind of microencapsulation complex vitamin premix and preparation method thereof.
The method be take PEG as carrier, and by processes such as heating and melting, emulsifying and spray congealings, vitamin is made finely dispersed microencapsulation complex vitamin premix the most at last.Due to the PEG mean molecule quantity, more than 3000, the vitamin molecules amount is below 440, and vitamin is protected because of the space that can enter the formation of PEG molecular spiral shape chain.The complex vitamin premix prepared with the present invention is actual is a kind of interstitial solid solution, wherein vitamin is uniformly distributed with crystallite or unformed pulverulence, the classification phenomenon can not occur in transportation, and good stability is difficult for destroyed in storage process and feed process.With the complex vitamin premix that the direct mixed method of tradition is produced, compare, the addition of microencapsulation complex vitamin premix in mixed feed prepared by the present invention can reduce 35-50%, and the production performance level of animal is unaffected.
The present invention reaches goal of the invention by following measure.First, by the PEG heating and melting, add successively various individual event vitamin and carry out emulsifying, finally by the spray congealing method, preparing the microencapsulation complex vitamin premix.
Contain PEG, vitamin A, vitamin D in the present invention's formula
3, vitamin E, vitamin K
3(MNB), Cobastab
1, Cobastab
2, Cobastab
6, Cobastab
12, folic acid, biotin, niacinamide, calcium pantothenate.
In formula, Contents of Main Components is: PEG 350-700g/kg, vitamin A 20-50g/kg, vitamin D
310-30g/kg, vitamin E 100-250g/kg, vitamin K
310-30g/kg, Cobastab
15-20g/kg, Cobastab
212-35g/kg, Cobastab
610-25g/kg, Cobastab
120.1-0.2g/kg, folic acid 3-10g/kg, biotin 0.1-1.5g/kg, niacinamide 50-200g/kg, calcium pantothenate 30-80g/kg.
PEG described in formula is two or more in PEG4000, PEG6000 and PEG8000.
Vitamin A described in formula can be one or more in retinyl acetate powder, retinyl acetate oil, and effective content is 1,000,000 IU/g.
Vitamin D described in formula
3it can be vitamin D
3powder, vitamin D
3one or more in oil, effective content is 500,000 IU/g.
Vitamin E described in formula can be one or more in pharmaceutical grade, food stage vitamin E oil, and effective content is 98%.
Preparation method of the present invention comprises the PEG melting, emulsifying, three steps of spray congealing.
The melting of PEG described in method can be any in normal pressure melting, negative pressure melting, require melting after the PEG temperature must not be over 80 ℃.
Emulsifying described in method adopts the high shear homogeneous emulsifying machine, and mulser is opened before adding various vitamin, and vitamin has added rear continuation emulsifying 5-10 minute.
During spraying described in method is cold, solidifying atomizing type can be any kind in centrifugal spraying, pressure type atomization, and condensing condition refers to the emulsion after atomization is directly sprayed into to the low temperature cold air, and air themperature requires lower than 10 ℃.
The specific embodiment
For further understanding the present invention, below with example, describe feature of the present invention, but example does not limit the right protection scope.It is only the part in the right protection scope.
Example
Formula: every 1000 gram content
Vitamin A 30 grams
Vitamin D
320 grams
Vitamin E 150 grams
Vitamin K
319 grams
Cobastab
111 grams
Cobastab
225 grams
Cobastab
612 grams
Cobastab
120.1 gram
Folic acid 5 grams
Biotin 0.4 gram
Niacinamide 100 grams
Calcium pantothenate 50 grams
PEG6000 577.5 grams
Preparation technology: the glass beaker that (1) 130 gram PEG6000 is added to 2000ml, beaker is placed in to heating while stirring on electric furnace, after its melting is liquid state, add gradually while stirring 447.5 gram PEG6000, the PEG6000 that total amount is 577.5 grams the most at last all melts for liquid state.(2) beaker is transferred on the emulsifier workbench of laboratory, the emulsifier working head is inserted to liquid PEG, open emulsifier, adjusting rotary speed makes liquid spin-up in beaker keep again the emulsifier working head below liquid level, adds successively the various individual event vitamins in formula.After all vitamin has added, heighten the emulsifier rotating speed, continue emulsification 5-10 minute.(3) the liquid B B-complex after emulsification is transferred in the container of manual paint sprayer, connect air compressor, pull trigger, directly vitamin is sprayed into to Cryogenic air (below 10 ℃), the drop of ejection forms granular substance and is the microencapsulation complex vitamin premix in the decline process.
The laying hen feeding experiment
25 week age, laying hen was 360, divided equally 4 groups, each 6 repetitions, and each repeats 15.Laying hen material experimental design is in Table 1.Test chicken free choice feeding, automatic drinking bowl drinking-water.Totally 4 weeks experimental period, the laying rate of determination test chicken, average egg weight, feed intake, feedstuff-egg ratio, result of the test is in Table 2.As seen from Table 2, test I group, contrast I group and test II group laying rate, feedstuff-egg ratio are without significant difference, but three groups of laying rate all are significantly higher than contrast II group, and feedstuff-egg ratio is all significantly lower than contrast II group.Contrast I group, test I group, test II group feed can both meet or the nutritional need to vitamin over laying hen.With respect to control group and test II group, test I group shows slight advantages in laying rate and two indexs of feedstuff-egg ratio, illustrates that its vitamin content has surpassed the laying hen nutritional need, and the slight advantages that show are from the improve of laying hen anti-stress ability.Contrast II laying rate and feed conversion rate, significantly lower than other three groups, prove that this group vitamin content can not meet the laying hen nutrition needs, and lower production performance causes by hypovitaminosis, and this shortage is relevant with the oxidation inactivation of storage life vitamin; Test II group vitamin premix addition is identical with contrast I group, but the production performance such as laying rate, feedstuff-egg ratio index is acted normally, show to test the II group and substantially can meet the nutritional need of laying hen to vitamin, be that vitamin stability in the microencapsulation complex vitamin premix is good, oxidational losses does not occur in storage process.
Table 1 laying hen material experimental design
Table 1 laying hen material experimental design
Table 2 laying hen material result of the test
The growing and fattening pigs feeding experiment
60 30 of age in days tri-crossbreedings, average weight 20kg, divide three groups, and control group adds 200 gram usual vitamin premixes, and test I group is added 200 gram example products, and test II organizes and adds 160 gram example products, 30 days experimental periods.The indexs such as the daily gain of determination test pig, feed intake, material anharmonic ratio, the results are shown in Table 3.As can be seen from Table 3, control group, test I group, test II group are in daily gain, feed intake, three indexs of material anharmonic ratio without significantly showing, product stability of the present invention is good, and addition reduces 40% can not affect the production performance of growing and fattening pigs.
Table 3 Performance of Finishing Pigs
Claims (10)
1. a microencapsulation complex vitamin premix formula, contain PEG, vitamin A, vitamin D
3, vitamin E, vitamin K
3(MNB), Cobastab
1, Cobastab
2, Cobastab
6, Cobastab
12, folic acid, biotin, niacinamide, calcium pantothenate.
2. a microencapsulation complex vitamin premix preparation method, comprise the PEG melting, emulsifying, three steps of spray congealing.
3. a microencapsulation complex vitamin premix formula as described as right 1, is characterized in that: PEG 350-700g/kg, vitamin A 20-50g/kg, vitamin D
310-30g/kg, vitamin E 100-250g/kg, Cobastab
120.1-0.2g/kg, biotin 0.1-1.5g/kg, vitamin K
310-30g/kg, Cobastab
15-20g/kg, Cobastab
212-35g/kg, Cobastab
610-25g/kg, folic acid 3-10g/kg, niacinamide 50-200g/kg, calcium pantothenate 30-80g/kg.
4. a microencapsulation complex vitamin premix as described as right 1 is filled a prescription, and it is characterized in that: PEG used is two or more in PEG4000, PEG6000 and PEG8000.
5. a microencapsulation complex vitamin premix as described as right 1 is filled a prescription, and it is characterized in that: vitamin A used can be one or more in feed grade retinyl acetate powder, food stage retinyl acetate oil, and effective content is 1,000,000 IU/g.
6. a microencapsulation complex vitamin premix formula as described as right 1, is characterized in that: vitamin D used
3it can be the feed grade vitamin D
3powder, food stage vitamin D
3one or more in oil, effective content is 500,000 IU/g.
7. a microencapsulation complex vitamin premix as described as right 1 is filled a prescription, and it is characterized in that: vitamin E used can be one or more in pharmaceutical grade vitamin E oil, food stage vitamin E oil, and effective content is 98%.
8. one kind as microencapsulation complex vitamin premix preparation method as described in right 2, it is characterized in that: the PEG melting can be any in normal pressure melting, negative pressure melting, require melting after the PEG temperature must not be over 80 ℃.
9. one kind as microencapsulation complex vitamin premix preparation method as described in right 2, and it is characterized in that: emulsifying adopts the high shear homogeneous emulsifying machine, and mulser is opened before adding various vitamin, and vitamin has added rear continuation emulsifying 5-10 minute.
10. one kind as microencapsulation complex vitamin premix preparation method as described in right 2, it is characterized in that: atomizing type can be any in centrifugal spraying, pressure type atomization, condensation method refers to the emulsion after atomization directly sprayed into to the low temperature cold air, and air themperature requires lower than 10 ℃.
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Cited By (6)
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| CN104351473A (en) * | 2014-10-22 | 2015-02-18 | 浙江万方生物科技有限公司 | Preparation method of water-soluble multivitamin micropills for livestock and poultry |
| CN104605142A (en) * | 2015-02-27 | 2015-05-13 | 浙江海洋学院 | Processing technology of microcapsule grouper microparticle feed |
| CN105831427A (en) * | 2016-03-24 | 2016-08-10 | 广州格雷特生物科技有限公司 | Sustained-release microcapsule-coated composite vitamin pre-mixed feed, preparation method and application thereof |
| CN107969704A (en) * | 2017-12-07 | 2018-05-01 | 山东禹王制药有限公司 | A kind of vitamin premix of suitable soft capsule preparation and preparation method thereof |
| CN108208344A (en) * | 2018-03-22 | 2018-06-29 | 广州立达尔生物科技股份有限公司 | A kind of feed addictive with liver protection and preparation method thereof |
| CN109170161A (en) * | 2018-09-03 | 2019-01-11 | 佛山市正典生物技术有限公司 | For improving the premix and preparation method thereof of pig feed intake and production performance |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104351473A (en) * | 2014-10-22 | 2015-02-18 | 浙江万方生物科技有限公司 | Preparation method of water-soluble multivitamin micropills for livestock and poultry |
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| CN104605142A (en) * | 2015-02-27 | 2015-05-13 | 浙江海洋学院 | Processing technology of microcapsule grouper microparticle feed |
| CN105831427A (en) * | 2016-03-24 | 2016-08-10 | 广州格雷特生物科技有限公司 | Sustained-release microcapsule-coated composite vitamin pre-mixed feed, preparation method and application thereof |
| CN107969704A (en) * | 2017-12-07 | 2018-05-01 | 山东禹王制药有限公司 | A kind of vitamin premix of suitable soft capsule preparation and preparation method thereof |
| CN108208344A (en) * | 2018-03-22 | 2018-06-29 | 广州立达尔生物科技股份有限公司 | A kind of feed addictive with liver protection and preparation method thereof |
| CN109170161A (en) * | 2018-09-03 | 2019-01-11 | 佛山市正典生物技术有限公司 | For improving the premix and preparation method thereof of pig feed intake and production performance |
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