CN108208344A - A kind of feed addictive with liver protection and preparation method thereof - Google Patents
A kind of feed addictive with liver protection and preparation method thereof Download PDFInfo
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- CN108208344A CN108208344A CN201810238044.6A CN201810238044A CN108208344A CN 108208344 A CN108208344 A CN 108208344A CN 201810238044 A CN201810238044 A CN 201810238044A CN 108208344 A CN108208344 A CN 108208344A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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Abstract
A kind of feed addictive with liver protection and preparation method thereof.Being developed using natural plant extracts silymarin as principle active component a kind of has the function of the feed addictive of liver protection.The technical problem to be solved is that silymarin unstable chemcial property, it is not shelf-stable, addition is of high cost the problem of and how to promote its application effect in animal feed.The powdered coating microparticle compound of good fluidity is made up of a kind of combination process by the present invention for silymarin, it can make silymarin content stable for extended periods of time in microparticle compound, good product mobility effectively improves its using effect, and manufacturing cost is relatively low.Results of animal shows that a kind of feed addictive with liver protection of the present invention has good protection animal's liver effect, while can improve cultivated animals growth performance.
Description
Technical field
The invention belongs to animal health fields, more particularly to a kind of to have the function of the feed addictive of liver protection and its preparation side
Method.
Technical background
Since Reformation and development, with the growth of the market demand, the development of feed industry, aquaculture development is rapid.At present I
More than 2 hundreds of millions tons/year, aquatic feeds rank the first in the world, more than 18,000,000 tons/year in the world state's industry feed total output
On occupy critical role.
Liver takes part in the performance of various functions such as animal body removing toxic substances, immune, digestion, hematopoiesis, is that animal is most heavy
One of organ wanted.It is influenced by many factors such as breeding environment, cultivation density, feed quality, aquaculture managements, is cultivated in recent years
The liver problems of animal are more.By taking culture fishery as an example, what disease problem associated with " liver and gall syndrome " was brought every year
It loses hundreds of millions of, very big loss and waste is caused to industry.Solve the problems, such as that this has important theoretical significance
And application value realistic.
Part natural plant extracts have good liver-protecting efficacy, relative to chemical synthetic drug, extracted form natural plant
Object safety, toxic side effect are small, and with good effect, receive more and more attention.Silymarin is feverfew water
Fly the extract of Ji, a variety of liver-protecting activity compositions contained, having numerous studies on animal confirms it with anti-oxidant, raising
Immune level repairs liver cell, liver-protective effect, but is used as a kind of natural, and silymarin exists chemically
The problems such as matter is unstable, not shelf-stable, addition is of high cost, effect expression differs seriously affects its answering in animal feed
With value.
The research in terms of silymarin preparation and patent have much so far, be concentrated mainly on medical applications field compared with
It is more, for example, by silymarin be made dripping pill, tablet, capsule, lipid nano particle, nano-emulsion, solid dispersions, phosphatide complexes with
And salt derivative etc., the characteristics of production according to general animal feed additive, there are program complexity, efficiency are low for these technologies
Under, the problem of with high costs, grain size is larger, dosage form is not inconsistent etc., can not directly apply mechanically.Compared to answering for field of medicaments
With addition milk thistle is known as its particularity in feed, in terms of being at least embodied in following four：First, animal feed composition of raw materials
Component is more, complicated component, and when addition needs to consider its influence to silymarin.Second, in animal feed production raw material it is mixed
Close the uniformity and directly affect product effect, the fineness and mobility of the additive kind raw material small to raw material especially additive amount have compared with
High request.Third, the packaging of animal feed, condition of storage are poor, certain unfavorable shadow may be caused to the stability of silymarin
It rings.Fourth, animal feed, to more demanding in terms of cost control, the manufacturing cost for the silymarin preparation being added in feed needs
It fully considers.The above problem is resolved, needs to be innovated in terms of the dosage form and processing technology of silymarin preparation.
Invention content
The present invention is a kind of guarantor developed using the extract silymarin in natural plants fine grinding Ji as principle active component
Protect the feed addictive of animal's liver.The technical problem to be solved is that silymarin unstable chemcial property, it is not shelf-stable, add
Add the problem of of high cost and how to promote its application effect in animal feed.The present invention is by a kind of combination process by water
The powdered coating microparticle compound of good fluidity is made in winged silibin, and silymarin content in microparticle compound can be made long
Phase keeps stablizing, and good product mobility effectively promotes its using effect, and manufacturing cost is relatively low.
The present invention solve above-mentioned technical problem technical solution be：
It is a kind of protect animal's liver feed addictive, using natural plants fine grinding Ji extract silymarin for mainly effectively into
Point, the powdered coating microparticle compound of good fluidity is made into using a kind of combination process, and pass through culture experiment
It is examined to protect animal's liver effect.
Further, the combination process includes six key steps.
Step 1: by spare by 200 mesh screens after silymarin ultramicro grinding；
It is made to be melt into liquid Step 2: coating agent is heated to 70 ~ 90 DEG C；
It is melted Step 3: silymarin sieving prepared by 10 parts by weight step 1 is added to 20 ~ 1000 parts by weight, 70 ~ 90 DEG C of heating
In the coating agent melted, the two is sufficiently mixed uniformly using high shear agitation method；
Step 4: mixture made from step 3 is delivered to cooling granulation top of tower by heat preservation charging pump, mixture passes through
Atomizer forms fine particle, and acting on rapid cooling and solidifying with cooling wind in granulation tower forms round bead shape solid granule, leads to
It crosses automatic sedimentation or cyclone separator separates and collects；
Step 5: particulate matter made from step 4 is made primary compound by 80 mesh reciprocating sieves, do not pass through big of sieve
High speed shear mixes secondary use to grain object again after 70 ~ 90 DEG C of heating meltings；
Step 6: by the primary compound described in 10 parts by weight step 5 and the rice bran of 1 ~ 100 parts by weight, maize cob meal, starch,
One or more ingredients in zeolite powder, silica, calcium carbonate are uniformly mixed, and the powdered coating that good fluidity is made is micro-
Particle composites.
Further, the silymarin includes silymarin or legalon contained by silymarin, different milk thistle
One or more of guest, silydianin, Silychristin.
Further, the coating agent described in combination process step 3, including stearic acid monoglyceride, lauric monoglyceride
One or more of ester, polyethylene glycol, poloxamer.
Further, the high speed shear mixed method described in combination process step 3 is, molten mixture is with blowing wall
Stirring（50~500rpm）And high-speed stirred（1400~2800rpm）High shear agitation machine in stir 30 ~ 120 minutes；
Further, the atomizer described in combination process step 4 can be centrifugal or pressure atomizer.
Further, the cooling wind described in combination process step 4 is prepared by refrigeration unit, inlet air temperature control for 5 ~
10 DEG C, leaving air temp control is 30-40 DEG C.
Further, a kind of to have the function of the feed addictive of liver protection, purposes is for producing animal feed.
The powdered microparticle compound of good fluidity of the present invention has the characteristics that：
1st, at low cost, material cost is not high, and preparation process is succinctly efficient, available for feed addictive large-scale production；
2nd, stability is good, and 1 year loss of effective components rate of normal temperature storage is less than 3%, and pellet processing loss is less than 4%, routine
3 months loss lates of feed storage are less than 5%；
3rd, mixture homogeneity is good, and powdered coating microparticle compound dispersibility, good fluidity, sample are added to feeding
The coefficient of variation CV values of effective ingredient are less than 4% in material, the professional standard less than 5%；
4th, effect expression is good, and by zoopery, product can protect liver, improve growth performance index, and effect is better than
Common silymarin.
Specific embodiment
Embodiment 1
A kind of preparation with liver protection functional feed additive：
1. Step 1: it is spare that silymarin ultramicro grinding is crossed 200 mesh screens；
2. it is made to be melt into clear weak yellow liquid Step 2: stearic acid monoglyceride is heated to 85 DEG C；
3. Step 3: silymarin prepared by 150 kilograms of step 1, which crosses reciprocating sieve, is added to 750 kilograms of 85 DEG C of heating meltings
Stearic acid monoglyceride in, with scrape wall stirring（60rpm）And high-speed stirred（2800rpm）High shear agitation machine in
Stirring 45 minutes；
4. Step 4: mixture made from step 3 is delivered to cooling granulation top of tower by heat preservation charging pump, mixture leads to
It crosses atomizer and forms fine particle, acting on rapid cooling and solidifying with cooling wind in granulation tower forms round bead shape solid granule,
It is separated and collected by automatic sedimentation or cyclone separator；
5. primary 720 kilograms of compound is made Step 5: collecting particulate matter from discharge port and crossing 80 mesh reciprocating sieves, it is not sieved big
Mixing machine high speed shear mixing secondary use is backed into after the 85 DEG C of heating meltings of grain object；
6. Step 6: by the primary compound described in 720 kilograms of step 5 and 480 kilograms of zeolite powder in powder mixer
Powdered 1200 kilograms of the coating microparticle compound of good fluidity is made in mixing 20 minutes.
Above description is only one of embodiment of the present invention, is not intended to limit scope of the presently claimed invention.
Embodiment 2
A kind of preparation with liver protection functional feed additive：
1. Step 1: it is spare that silymarin ultramicro grinding is crossed 200 mesh screens；
2. it is made to be melt into clear colourless liquid Step 2: polyethylene glycol is heated to 80 DEG C；
3. Step 3: silymarin prepared by 100 kilograms of step 1, which crosses reciprocating sieve, is added to 500 kilograms of 70 DEG C of heating meltings
Macrogol 4000 in, with scrape wall stirring（100rpm）And high-speed stirred（2500rpm）High shear agitation machine in
Stirring 60 minutes；
4. Step 4: mixture made from step 3 is delivered to cooling granulation top of tower by heat preservation charging pump, mixture leads to
It crosses atomizer and forms fine particle, acting on rapid cooling and solidifying with cooling wind in granulation tower forms round bead shape solid granule,
It is separated and collected by automatic sedimentation or cyclone separator；
5. primary 510 kilograms of compound is made Step 5: collecting particulate matter from discharge port and crossing 80 mesh reciprocating sieves, it is not sieved big
Mixing machine high speed shear mixing secondary use is backed into after the 80 DEG C of heating meltings of grain object；
6. Step 6: by the primary compound described in 510 kilograms of step 5 and 510 kilograms of rice bran, 510 kilograms of titanium dioxide
Silicon mixes 20 minutes in powder mixer, and powdered 1530 kilograms of the coating microparticle compound of good fluidity is made.
Above description is only one of embodiment of the present invention, is not intended to limit scope of the presently claimed invention.
Embodiment 3：Bin stability is tested
3 batch samples of feed addictive of the present invention are taken, each batch sample, which is uniformly mixed, is divided into 6 bags, every bag
20g, aluminium foil bag hermetic package.Sample is packed, is placed under room temperature disposed within, detects initial silymarin content
（HPLC）With place 12 months after content.All samples involved in experiment are tested by identical lab technician.It is each flat
Row sample is detected simultaneously by two lab technicians, and the arithmetic mean of instantaneous value for taking both sides is final result.Detection shows 12 months shelf lifes
Sample active ingredient silymarin loss late is respectively 2.19%, 2.03% and 2.16%, average value 2.13%, active constituent content
Loss late is little, illustrates that product stability is good.
Embodiment 4：Mixture homogeneity is tested
Tilapia mossambica basal feed formula, by weight percentage：Fish meal 5%, dregs of beans 20%, rapeseed meal 25%, cotton dregs 18%, flour 25%,
Soyabean lecithin oil 2%, soybean oil 3%, calcium dihydrogen phosphate 0.2%, vitamin premix 0.5%, mineral substance premix 0.5%, chlorination courage
Alkali 0.2%, salt 0.6%.The of the present invention of addition 0.02% has the function of the feeding of liver protection in Tilapia mossambica basal feed formula
1 ton of Tilapia mossambica pellet is made in feed additives.
6 parts of samples of random acquisition in feed are tested from above-mentioned 1 ton of Tilapia mossambica, are contained using HPLC analytic approach detection silymarin
Amount, data measured is respectively 9.42,8.87,8.56,8.62,8.85,9.25ppm, coefficient of variation CV values are 3.84%, sample
Mobility, mixture homogeneity are good.
Embodiment 5：Feed processing, storage stability experiment
Tilapia mossambica basal feed formula, by weight percentage：Fish meal 5%, dregs of beans 20%, rapeseed meal 25%, cotton dregs 18%, flour 25%,
Soyabean lecithin oil 2%, soybean oil 3%, calcium dihydrogen phosphate 0.2%, vitamin premix 0.5%, mineral substance premix 0.5%, chlorination courage
Alkali 0.2%, salt 0.6%.The of the present invention of addition 0.02% has the function of the feeding of liver protection in Tilapia mossambica basal feed formula
1 ton of Tilapia mossambica pellet is made in feed additives, and silymarin theoretical content is 9.22ppm in feed.
6 parts of samples of random acquisition in feed are tested from above-mentioned 1 ton of Tilapia mossambica, every part of 200g is separated into 2 parts, and 12 is small altogether
Part, it is respectively charged into common valve bag and preserves, silymarin content and room temperature in fresh feed are detected using HPLC analytic approach
Store silymarin content in three months feeds.Measure silymarin content in fresh feed be respectively 9.42,8.87,8.56,
8.62nd, 8.85,9.25ppm, average value 8.93ppm, processing loss 3.15%；Measure milk thistle in three months feeds of storage
Cellulose content is respectively 9.33,8.90,8.48,8.45,8.76,8.79ppm, average value 8.78ppm, three months standing losses rates
1.68%.Generally added in feed it is of the present invention there is the feed addictive of liver protection, during processing, storage
The loss late of active ingredient silymarin is little.
Embodiment 6：Liver of hybrid tilapia protects zoopery
Tilapia mossambica basal feed formula, by weight percentage：Fish meal 5%, dregs of beans 20%, rapeseed meal 25%, cotton dregs 18%, flour 25%,
Soyabean lecithin oil 2% aoxidizes soybean oil 3%, calcium dihydrogen phosphate 0.2%, vitamin premix 0.5%, mineral substance premix 0.5%, chlorine
Change choline 0.2%, salt 0.6%.
The feed addition with liver protection of the present invention of addition 0.02% in Tilapia mossambica basal feed formula
Tilapia mossambica experiment feed 1 is made in agent, and addition is with testing the general of 1 equivalent active ingredient of feed in Tilapia mossambica basal feed formula
Tilapia mossambica experiment feed 2 is made in logical silymarin.
Above-mentioned Tilapia mossambica basal feed and Tilapia mossambica is selected to test feed and carry out culture of Penaeus vannamei contrast test, is fed
The group of basal feed is set as control group, and the group for feeding experiment feed 1 is set as experimental group 1, and the group for feeding experiment feed 2 is set as testing
Group 2, each group sets 3 repetitions.20 square metres of 9 open area, consistent cement pit is selected to carry out experiment.Culture experiment water
Deep control is 1.0 meters, and pH controls are 7.8-8.5, ammonia control be 0.6ppm hereinafter, nitrite control be 0.3ppm hereinafter,
28-32 DEG C of water temperature, mainly by blowdown, change water adjusting control water quality.Every mouthful of experiment pool puts average size 56 ± 0.46g/ tails in a suitable place to breed
50 tail of Tilapia mossambica, planning of experiments cultivate two months, feed 3 meal feeds daily.
The practical culturing time of this experiment Tilapia mossambica is 63 days, and experiment terminates control group survival rate, feed coefficient, rate of body weight gain point
Not Wei 84.7%, 1.37,373.2, and feed and be added to the experimental group with the feed addictive of liver protection of the present invention
1 survival rate, feed coefficient, rate of body weight gain are respectively 98.0%, 1.05,413.5,2 survival rate of experimental group, feed coefficient, rate of body weight gain point
Not Wei 92.6%, 1.16,402.7, result of the test shows in terms of production performance that experimental group 1 is added to and of the present invention has
The feed addictive best results of liver protection function.
Experiment terminates every mouthful of pond and takes 2 fish dissections at random, observes liver color, and detect liver pancreas biochemical indicator.Control
Group feed is added to oxidation grease, and liver of hybrid tilapia is caused to be damaged, and hepatic fibrosis-renal tubular ectasia syndrome, blushing are apparent, and adds the present invention
A kind of 1 hepatic fibrosis-renal tubular ectasia syndrome situation of experimental group with liver protection functional feed additive obtains being relieved even unknown
Aobvious, liver also gain color, experimental group 2 also has good result compared to the control group, but the ruddy of liver, smooth degree are not so good as experimental group
1, illustrate that one kind of the present invention has liver protection functional feed additive to hepar damnification protective effect caused by oxidation grease
It is best.
Embodiment 7
Penaeus Vannmei liver protecting zoopery
Penaeus Vannmei basal feed formula, by weight percentage：Fish meal 20%, dregs of beans 26%, cotton dregs 6%, rapeseed meal 10%, peanut
The dregs of rice 15%, wheat-middlings 17%, premix 5%, grease 1%.
The feed with liver protection of the present invention of addition 0.01% adds in Penaeus Vannmei basal feed formula
Add agent, Penaeus Vannmei experiment feed 1 is made, being added in Penaeus Vannmei basal feed formula has with experiment 1 equivalent of feed
The common silymarin of ingredient is imitated, Penaeus Vannmei experiment feed 2 is made.
Above-mentioned Penaeus Vannmei basal feed and Penaeus Vannmei is selected to test feed and carry out culture of Penaeus vannamei comparison
Experiment, the group for feeding basal feed are set as control group, and the group for feeding experiment feed 1 is set as experimental group 1, feed experiment feed 2
Group is set as experimental group 2, and each group sets 3 repetitions.20 square metres of 9 open area, consistent cement pit is selected to carry out experiment.It supports
Grow the control of the experiment pool depth of water for 1.0 meters, it is 7.8-8.5 that the control of water salinity, which be 3 ‰, pH controls, ammonia control be 0.6ppm with
Under, nitrite control is 0.3ppm hereinafter, 28-32 DEG C of water temperature, mainly by blowdown, change water adjusting control water quality.Per cause for gossip
10000 tail of Penaeus Vannmei two generations juvenile prawn that average size 0.5g/ tails are put in pond in a suitable place to breed is tested, planning of experiments cultivates two months, throws daily
Feed 3 meal feeds.
The practical culturing time of this experiment prawn is 63 days, and experiment terminates control group survival rate, feed coefficient, rate of body weight gain difference
Be 81.2%, 1.26,2766.3, feed be added to the experimental group 1 with the feed addictive of liver protection of the present invention into
Motility rate, feed coefficient, rate of body weight gain are respectively 89.5%, 1.12,3240.6,2 survival rate of experimental group, feed coefficient, rate of body weight gain difference
It is 86.3%, 1.19,3071.4, production performance index, which is added to, of the present invention has the function of the feed addictive of liver protection
Experimental group 1 is best.During entire experiment, the shrimp vigor of experimental group 1 is good, ingests that fast, body colour blueness is bright, and especially hepatopancrease color begins
Sepia is kept eventually, and hepatopancrease white coating is clear, complete, generally prawn of the performance better than other two groups.Recent year
Shrimp culture industry is by AHPND（Acute Hepatic pancreatic necrosis）It influences, average product offset sharper slowdowns, the present invention is to restoring prawn industry
Development has potential value.
Claims (7)
1. a kind of preparation method with the feed addictive of liver protection, combination process includes six key steps：
Step 1: by spare by 200 mesh screens after silymarin ultramicro grinding；
It is made to be melt into liquid Step 2: coating agent is heated to 70 ~ 90 DEG C；
It is melted Step 3: silymarin sieving prepared by 10 parts by weight step 1 is added to 20 ~ 1000 parts by weight, 70 ~ 90 DEG C of heating
In the coating agent melted, the two is sufficiently mixed uniformly using high shear agitation method；
Step 4: mixture made from step 3 is delivered to cooling granulation top of tower by heat preservation charging pump, mixture passes through
Atomizer forms fine particle, and acting on rapid cooling and solidifying with cooling wind in granulation tower forms round bead shape solid granule, leads to
It crosses automatic sedimentation or cyclone separator separates and collects；
Step 5: particulate matter made from step 4 is made primary compound by 80 mesh reciprocating sieves, do not pass through big of sieve
High speed shear mixes secondary use to grain object again after 70 ~ 90 DEG C of heating meltings；
Step 6: by the primary compound described in 10 parts by weight step 5 and the rice bran of 1 ~ 100 parts by weight, maize cob meal, starch,
One or more ingredients in zeolite powder, silica, calcium carbonate are uniformly mixed, and the powdered coating that good fluidity is made is micro-
Particle composites.
A kind of there is the feed addictive of liver protection 2. according to claim 1, which is characterized in that with natural plant water
Fly feed addictive of the extract silymarin for a kind of protection animal's liver of principle active component exploitation in Ji.
A kind of there is the feed addictive of liver protection 3. according to claim 1, which is characterized in that a kind of mobility is good
Good powdered coating microparticle compound.
4. coating agent according to claim 1, which is characterized in that including stearic acid monoglyceride, lauric monoglyceride,
One or more of polyethylene glycol, poloxamer.
5. atomizer according to claim 1, which is characterized in that can be centrifugal or pressure atomizer.
6. silymarin according to claim 1, which is characterized in that including the fine grinding contained by silymarin or silymarin
One or more of Ji guest, Isosilybin, silydianin, Silychristin.
7. a kind of described in has the function of the feed addictive of liver protection, and purposes is for producing animal feed.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109170161A (en) * | 2018-09-03 | 2019-01-11 | 佛山市正典生物技术有限公司 | For improving the premix and preparation method thereof of pig feed intake and production performance |
| CN109601722A (en) * | 2018-12-17 | 2019-04-12 | 广东有机宝生物科技股份有限公司 | A kind of preparation method of lauric monoglyceride coating plants essential oil |
| CN109699820A (en) * | 2019-03-06 | 2019-05-03 | 广州立达尔生物科技股份有限公司 | A kind of preparation method, additive and the feed of the natural alkaloid feed addictive improving prawn culturing survival rate |
| EP4014757A1 (en) * | 2020-09-04 | 2022-06-22 | GITES GmbH | Preparation comprising silymarin, method for producing and use thereof |
| CN116035123A (en) * | 2022-12-29 | 2023-05-02 | 东北农业大学 | Application of silybin in preparing feed additive for regulating and controlling rumen methane emission of ruminant |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109170161A (en) * | 2018-09-03 | 2019-01-11 | 佛山市正典生物技术有限公司 | For improving the premix and preparation method thereof of pig feed intake and production performance |
| CN109601722A (en) * | 2018-12-17 | 2019-04-12 | 广东有机宝生物科技股份有限公司 | A kind of preparation method of lauric monoglyceride coating plants essential oil |
| CN109699820A (en) * | 2019-03-06 | 2019-05-03 | 广州立达尔生物科技股份有限公司 | A kind of preparation method, additive and the feed of the natural alkaloid feed addictive improving prawn culturing survival rate |
| EP4014757A1 (en) * | 2020-09-04 | 2022-06-22 | GITES GmbH | Preparation comprising silymarin, method for producing and use thereof |
| CN116035123A (en) * | 2022-12-29 | 2023-05-02 | 东北农业大学 | Application of silybin in preparing feed additive for regulating and controlling rumen methane emission of ruminant |
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Application publication date: 20180629 |