CN103735687B - A kind of Weight reducing compound and preparation method thereof - Google Patents
A kind of Weight reducing compound and preparation method thereof Download PDFInfo
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- CN103735687B CN103735687B CN201310745455.1A CN201310745455A CN103735687B CN 103735687 B CN103735687 B CN 103735687B CN 201310745455 A CN201310745455 A CN 201310745455A CN 103735687 B CN103735687 B CN 103735687B
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Abstract
The present invention provides a kind of Weight reducing compound and preparation method thereof, and described Weight reducing compound includes the raw material of following weight portion: Citrus young fruit extract 100-400, Fructus Mali pumilae young fruit extract 50-500 and green coffee bean extract 200-600.Weight reducing compound provided by the invention, Citrus young fruit extract, Fructus Mali pumilae young fruit extract, green coffee bean extract are carried out composite in specific proportions, the Citrus polyphenol contained in compositions and apple polyphenol can suppress fat digestion activity, suppress the human body absorption to fat food, green coffee bean extract has acceleration body metabolism, improves burning of body fat, when normal diet, effectively reduce the absorption of energy, decontrol body weight.
Description
Technical field
The present invention relates to field of health care products, specifically, relate to a kind of Weight reducing compound and preparation method thereof.
Background technology
Obesity is that Energy intaking exceedes energy expenditure and causes that body fat gathers too much, and reaches a kind of chronic metabolic disease of the extent of injury.At present, there are overweight or nearly 300,000,000 people of overweight people in China, and wherein overweight the or fat ratio of more than 18 years old adult respectively reaches 22.8% and 7.1%.Along with the raising of health perception, increasing it is recognized that obesity has become the very important able-bodied risk factor of serious threat people.
At present, the fat-reducing article on market include appetrol and slimming health food, although the fat-reducing effect of appetrol is more apparent, but ubiquity side effect greatly, the shortcoming that drug dependence is strong.Although and slimming health food is absent from side effect and dependency, but how inconspicuous fat-reducing effect is.
Polyatomic phenol material is widely present in fruit and vegetable, and polyphenol content is different because of fruit maturity, and the polyphenol content of crude fruit is 10 times of mellow fruit, therefore extraction Citrus and apple polyphenol adopt crude fruit to be advisable.Citrus young fruit extract, Fructus Mali pumilae young fruit extract all contain the fruit polyphenol of high level, polyphenol substance is except having effect of antioxidation and antiinflammatory, also has the effect of Weight-reducing and lipid-lowering, Li Jianxin in 2008 shows in Food Science periodical result of publishing an article, apple polyphenol can effectively reduce Mouse Weight and fat weight, has the effect reducing cholesterolemia and triglyceride simultaneously.Green coffee bean extract derives from the seed of Maguireothamnus speciosus Coffea arabica, middle fruit coffee and big fruit coffee.It is mainly composed of chlorogenic acid, has the effects such as blood pressure lowering, antitumor, the kidney invigorating, antioxidation, fat-reducing.
Summary of the invention
It is an object of the invention to provide a kind of Weight reducing compound and preparation method thereof.
In order to realize the object of the invention, a kind of Weight reducing compound of the present invention, including the raw material of following weight portion: Citrus young fruit extract 100-400, Fructus Mali pumilae young fruit extract 50-500 and green coffee bean extract 200-600.
Preferably, described Weight reducing compound includes the raw material of following weight portion: Citrus young fruit extract 200-300, Fructus Mali pumilae young fruit extract 200-400 and green coffee bean extract 300-500.
The Weight reducing compound of the present invention also includes 100-10000 part excipient.Excipient is selected from one or more in starch, dextrin, Pulvis Talci, cane sugar powder, ethanol, microcrystalline Cellulose, lactose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, magnesium stearate and micropowder silica gel etc..
The Weight reducing compound of the present invention can be made different dosage form, for instance tablet, capsule or granule etc..
The weight portion related in the present invention can be the known measurement units of field of food such as μ g, mg, g, kg.
The preparation method that the present invention also provides for described Weight reducing compound, weighs each raw material by proportioning, sieves, and mixes and get final product.
Wherein, the preparation method of Citrus young fruit extract is: 80% ethanol extraction of 6 times of young fruit weight of addition 2 times in Citrus young fruit, each 1.5 hours, and united extraction liquid reclaims ethanol, and vacuum concentrates, and spray drying obtains Citrus young fruit extract.
The preparation method of Fructus Mali pumilae young fruit extract is: 70% ethanol extraction of 5 times of young fruit weight of addition 2 times in Fructus Mali pumilae young fruit, each 1.5 hours, and united extraction liquid reclaims ethanol, and vacuum concentrates, and spray drying obtains Fructus Mali pumilae young fruit extract.
The preparation method of green coffee bean extract is: the water extraction of 8 times of coffee bean weight of addition 2 times in green coffee bean, each 2 hours, and united extraction liquid, vacuum concentrates, and spray drying obtains green coffee bean extract.
Weight reducing compound provided by the invention, Citrus young fruit extract, Fructus Mali pumilae young fruit extract, green coffee bean extract are carried out composite in specific proportions, the Citrus polyphenol contained in compositions and apple polyphenol can suppress fat digestion activity, suppress the human body absorption to fat food, green coffee bean extract has acceleration body metabolism, improves burning of body fat, when normal diet, effectively reduce the absorption of energy, decontrol body weight.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.If not specializing, the conventional means that technological means used in embodiment is well known to those skilled in the art, raw materials used it is commercial goods.
Embodiment 1 Weight reducing compound capsule and preparation thereof
With Citrus young fruit extract, Fructus Mali pumilae young fruit extract, green coffee bean extract for raw material, cross 40 mesh sieves respectively, standby.
Weigh following raw material respectively: Citrus young fruit extract 100g, Fructus Mali pumilae young fruit extract 500g, green coffee bean extract 200g, starch 800g, then each raw material is mixed, stir, pour capsule into and fill in mould, fill capsule, polishing, subpackage, obtains 4000,0.4g/ grain.Wherein, every containing Citrus young fruit extract 0.025g, Fructus Mali pumilae young fruit extract 0.125g, green coffee bean extract 0.05g.
Embodiment 2 Weight reducing compound granule and preparation thereof
With Citrus young fruit extract, Fructus Mali pumilae young fruit extract, green coffee bean extract for raw material, cross 40 mesh sieves respectively, standby.
Weigh following raw material respectively: Citrus young fruit extracts 400g, Fructus Mali pumilae young fruit extract 50g, green coffee bean extract 600g, cane sugar powder 3950g, then raw material is mixed, stir; use 50% ethanol as binding agent; soft material processed, makes granule by above-mentioned soft material in the oscillating granulator of 14 eye mesh screens, is moved into by granule in multi-functional boiling drier; 50 DEG C of airpillow-dry about 40 minutes; control pellet moisture 5%, then granulate, subpackage; obtain 5000g, 5g/ bag.Wherein, every bag containing Citrus young fruit extract 0.4g, Fructus Mali pumilae young fruit extract 0.05g, green coffee bean extract 0.6g.
Embodiment 3 Weight reducing compound tablet and preparation thereof
With Citrus young fruit extract, Fructus Mali pumilae young fruit extract, green coffee bean extract for raw material, cross 80 mesh sieves respectively, standby.
Weigh following raw material respectively: Citrus young fruit extracts 200g, Fructus Mali pumilae young fruit extract 400g, green coffee bean extract 300g, lactose 900g, microcrystalline Cellulose 180g; then raw material is mixed; stir; use 50% ethanol as binding agent; soft material processed, makes granule by above-mentioned soft material in the oscillating granulator of 14 eye mesh screens, is moved into by granule in drying machine; 50 DEG C dry about 40 minutes; control pellet moisture 5%, granulate, in granule, then add magnesium stearate 20g; total mixed; tabletting, film coating, subpackage; obtain 4000,0.5g/ sheet.Wherein, every containing Citrus young fruit extract 0.05g, Fructus Mali pumilae young fruit extract 0.1g, green coffee bean extract 0.075g.
Embodiment 4 Weight reducing compound capsule and preparation thereof
With the preparation method in embodiment 1, prescription is different.
The prescription of the present embodiment is: Citrus young fruit extract 300g, Fructus Mali pumilae young fruit extract 200g, green coffee bean extract 500g, starch 600g.Obtain 4000 capsules, 0.4g/ grain altogether.Wherein, every containing Citrus young fruit extract 0.075g, Fructus Mali pumilae young fruit extract 0.05g, green coffee bean extract 0.125g.
Embodiment 5 Weight reducing compound capsule and preparation thereof
With the preparation method in embodiment 1, prescription is different.
The prescription of the present embodiment is: Citrus young fruit extract 260g, Fructus Mali pumilae young fruit extract 280g, green coffee bean extract 460g, starch 600g.Obtain 4000 capsules, 0.4g/ grain altogether.Wherein, every containing Citrus young fruit extract 0.065g, Fructus Mali pumilae young fruit extract 0.07g, green coffee bean extract 0.115g.
The application effect of embodiment 6 Weight reducing compound of the present invention
1 experimental subject and method
1.1 experimental subjecies
The whole experimenter of this experiment carries out constitutional index assessment on pretreatment respectively and is obese people, male 20 examples in 42 example experimenters, female 22 example；Age between 21-55 year, year mean age (39.7 ± 8.5)；
1.2 experimental techniques
Packet: 42 experimenters are randomly divided into three groups, negative control group (N=7), positive control one group (N=7), positive control two groups (N=7), positive control three groups (N=7), experimental group one group (N=7), tests two groups (N=7).Negative control group takes placebo, 4/day；Positive control one group takes Citrus young fruit extract capsule, 4/day；Positive control two groups takes Fructus Mali pumilae young fruit extract capsule, 4/day；Positive control three groups takes green coffee bean extract capsule, 4/day；Test one group of fat-reducing composite capsule group (embodiment 1) taking the present invention, 4/day；Test two groups of fat-reducing composite capsule groups (embodiment 5) taking the present invention, 4/day；Take 4 weeks continuously.During whole experiment, do not keep on a diet, deliberately do not increase motion, and taboo takes other diet food and medicine.
1.3 test indexs
1.3.1 body composition test: adopt weekly the body weight of DX200 super strong type body composition test instrument test experimenter, body fat percentage before experiment and after experiment.
1.4 data statisticss
The data obtained Excel process, adopts mono blind method and t inspection that test data are carried out statistical analysis, represents with mean ± SD.
2 experimental results and analysis
2.1 body composition analysis results
2.1.1 subject re-detection result before and after experiment
Experimenter's body weight situation of change before and after table 1 experiment
There is significant difference (P < 0.05) before and after note: * experiment, before and after * * experiment, have pole significant difference (P < 0.01)
As can be seen from Table 1, negative control group, positive controls and experimental group test after compared with before experiment body weight all decrease, wherein positive controls has significant difference (P < 0.05), and experimental group has pole significant difference (P < 0.01)；The amplitude of experimental group weight loss is greater than positive controls.
2.1.2 body fat percentage testing result before and after experiment
Table 2 experimenter's body fat percentage testing result
* there is significant difference (P < 0.05) before and after experiment, before and after * * experiment, have pole significant difference (P < 0.01)
As can be seen from Table 2, negative control group, positive controls and experimental group test after compared with before experiment body fat percentage all decrease, wherein positive controls has significant difference (P < 0.05), and experimental group has pole significant difference (P < 0.01)；The amplitude that experimental group body fat percentage declines is greater than positive controls.
2.2 take slimming capsule subjective feeling
All there is not obvious adverse reaction during taking in all experimenters.There is 1 experimenter that the symptom of anorexia, constipation occurred at the initial stage of taking medicine, above transference cure after taking 1 week.
3 conclusions
After testing, the Weight reducing compound for other embodiments of different prescriptions has slimming effect equally, reduces percent weight simultaneously.
Although, above the present invention is described in detail with a general description of the specific embodiments, but on basis of the present invention, it is possible to it is made some modifications or improvements, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (6)
1. a Weight reducing compound, it is characterized in that, the active component of described Weight reducing compound is made up of the raw material of following weight portion: Citrus young fruit extract 100-400, Fructus Mali pumilae young fruit extract 50-500 and green coffee bean extract 200-600, the preparation method of described Citrus young fruit extract is: 80% ethanol extraction of 6 times of young fruit weight of addition 2 times in Citrus young fruit, each 1.5 hours, united extraction liquid, reclaim ethanol, vacuum concentrates, and spray drying obtains Citrus young fruit extract；The preparation method of described Fructus Mali pumilae young fruit extract is: 70% ethanol extraction of 5 times of young fruit weight of addition 2 times in Fructus Mali pumilae young fruit, each 1.5 hours, and united extraction liquid reclaims ethanol, and vacuum concentrates, and spray drying obtains Fructus Mali pumilae young fruit extract；The preparation method of described green coffee bean extract is: the water extraction of 8 times of coffee bean weight of addition 2 times in green coffee bean, each 2 hours, and united extraction liquid, vacuum concentrates, and spray drying obtains green coffee bean extract.
2. Weight reducing compound according to claim 1, it is characterised in that the active component of described Weight reducing compound is made up of the raw material of following weight portion: Citrus young fruit extract 200-300, Fructus Mali pumilae young fruit extract 200-400 and green coffee bean extract 300-500.
3. Weight reducing compound according to claim 1, it is characterised in that described Weight reducing compound also includes 100-10000 part excipient.
4. Weight reducing compound according to claim 3, it is characterized in that, described excipient is selected from one or more in starch, dextrin, Pulvis Talci, cane sugar powder, ethanol, microcrystalline Cellulose, lactose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, magnesium stearate and micropowder silica gel.
5. the Weight reducing compound according to any one of claim 1-4, it is characterised in that the dosage form of described Weight reducing compound is tablet, capsule or granule.
6. the preparation method of Weight reducing compound described in any one of claim 1-5, it is characterised in that weigh each raw material by proportioning, sieve, mix and get final product.
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| CN104138002A (en) * | 2014-08-05 | 2014-11-12 | 溧阳市天目湖保健品有限公司 | Health food with weight reducing function and preparing method of health food |
| CN104546736A (en) * | 2014-12-25 | 2015-04-29 | 北京科源创欣科技有限公司 | Pediatric loperamide hydrochloride granules and preparation process thereof |
| TWI667036B (en) * | 2017-04-03 | 2019-08-01 | 大江生醫股份有限公司 | Use of plant extracts on regulating pdgfc, fgf2, igf1r, ptgis, nos3, edn1, plat, proc, vwf, f3, serpine1, il-8, icam1, vcam1 and casp8 genes |
| CN107048365B (en) * | 2017-04-20 | 2018-07-03 | 北京市永康年健康科技有限责任公司 | A kind of citrus guarana product for being used for weight-reducing and its preparation method and application |
| CN107307406B (en) * | 2017-08-01 | 2020-08-25 | 湖南康琪壹佰生物科技有限公司 | Weight-losing tablet and preparation method thereof |
| CN107625122A (en) * | 2017-09-27 | 2018-01-26 | 高恩来 | A kind of vegetable protein compounds powder nutritious food |
| CN107637746A (en) * | 2017-10-20 | 2018-01-30 | 成都天美膳营养食品有限公司 | It is a kind of that there is fruity compound solid beverage that is anti-oxidant and improving metabolic function |
| CN115969045A (en) * | 2021-10-14 | 2023-04-18 | 南京盛德生物科技研究院有限公司 | Composition with weight health management function and preparation method and application thereof |
| CN115053963A (en) * | 2022-06-28 | 2022-09-16 | 仙乐健康科技股份有限公司 | Composition for improving body temperature and promoting body surface microcirculation |
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| KR100728055B1 (en) * | 2005-02-24 | 2007-06-13 | (주)바이오뉴트리젠 | food for preventing fatness and hyperlipemia |
| CN101390975A (en) * | 2008-11-25 | 2009-03-25 | 湖南农业大学 | Extraction method of citrus active ingredient |
| CN103099873A (en) * | 2013-02-28 | 2013-05-15 | 安吉依思味食品有限公司 | Green coffee bean extract sustained-release tablet and preparation method thereof |
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