CN104922167A - Ganoderma lucidum spore powder electuary and preparation method thereof - Google Patents
Ganoderma lucidum spore powder electuary and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a ganoderma lucidum spore powder electuary. The electuary comprises a raw material and an auxiliary material; the mass ratio of the raw material to the auxiliary material is 1-3:3-5, the raw material is cell-wall-broken ganoderma lucidum spore powder, and the auxiliary material is a mixture of cyclodextrin and maltodextrin. The preparation method of the ganoderma lucidum spore powder electuary comprises the steps that the cell-wall-broken ganoderma lucidum spore powder is prepared to be used as the raw material, the cyclodextrin and the maltodextrin are weighed respectively, and the weighed cyclodextrin and the weighed maltodextrin are evenly mixed to serve as the auxiliary material; the raw material and the auxiliary material are weighed respectively and mixed evenly, then a wetting agent is sprayed to a mixture, and the mixture is stirred evenly to be used as a standby; the mixture is prepared into particles, then the particles are dried under the condition of 60 DEG C, finally the particles pass through a screen with the mesh number ranging from 20 to 100, vacuum packing is conducted, and the finished product is obtained. The ganoderma lucidum spore powder electuary is easy to carry and can be drunk by dissolving directly, all ingredients of the electuary supplement one another, the electuary is easy to absorb, the preparation method is easy, mass production and use are convenient, and the healthcare function that the immunity can be boosted is achieved.
Description
Technical field
The present invention relates to a kind of Chinese herbal and crude drugs preparations, in particular to a kind of Ganoderma spore medicinal granules of powder, and the preparation method of this Ganoderma spore medicinal granules of powder.
Background technology
Ganoderma spore powder contains Ganoderma albumen, polysaccharide, the various active compositions such as triterpene, there is antitumor, protecting liver and detoxication, angiocardiopathy preventing, antiallergic, defying age, neurasthenia, treatment hypertension, chronic bronchitis, the effects such as bronchial asthma, particularly there is obvious inhibitory action to kinds of tumor cells, coordinate the radiotherapy being used for malignant tumor patient, chemotherapy, the toleration of patient can be strengthened, alleviate side effect, improve hemopoietic function of bone marrow, increase leukocytic transfer, recurrence, strengthen immunocompetence, patient with advanced cancer can health invigorating and anti-cancer ability after taking, alleviate generation and the development of complication, extend survival period.
Except medical application, Ganoderma spore powder also occupies certain market and status in industries such as food, beverage and health product, has higher economic worth.Ganoderma spore powder had both been different from the therapeutical effect of general medicine to certain disease; also be different from general nutritional health food only to carry out supplementing and strengthening to the deficiency of nutrient in a certain respect; its unique distinction is mainly two-ways regulation function of human body to balance on the whole; transfer internal body vigor; regulate human metabolism; improve autoimmune ability, impel whole internal organs or organ function normalization, thus fundamentally reach the object of health care of promoting health and curing diseases.
At present, the application for Ganoderma spore powder still needs, just can use after decoction method formation decoction, to carry and drink equal inconvenience.Although Chinese scholars has carried out the research to different instant particles as Chinese medicine granule, and obtain certain achievement, as, Radix Rehmanniae Compatible Granule, Astragalus granules, permanently happy granule, male Chinese herbaceous peony granule, control strongly fragrant granule, Radix Isatidis granule etc., exempt to decoct because this electuary has, the advantage such as portable, taking convenience, enjoy doctors and patients to favor.But up to the present, development about Ganoderma spore medicinal granules of powder was not also reported, the research for Ganoderma spore medicinal granules of powder still belongs to the market vacancy, therefore, how to solve Ganoderma spore powder because of not Portable belt, drink and limit its application, be that this field needs the difficult problem that solves at present.
Summary of the invention
The object of this invention is to provide a kind of Ganoderma spore medicinal granules of powder and preparation method thereof, this Ganoderma spore medicinal granules of powder has easy to carry, can the advantage of direct taking medicine after mixing with water, the preparation method of this Ganoderma spore medicinal granules of powder have technique simple, implement the feature that is easy to.
For the application solving Ganoderma spore powder in prior art needs with just drinkable after decoction method formation decoction, carry and drink all inconvenient technical problem, the invention provides a kind of Ganoderma spore medicinal granules of powder and preparation method thereof, this Ganoderma spore medicinal granules of powder comprises stock and adjunct, the mass ratio of raw material and adjuvant is 1 ~ 3:3 ~ 5, raw material is Ganoderma spore powder with cellular wall broken, and adjuvant is the mixture of cyclodextrin and maltodextrin.
Further, a kind of Ganoderma spore medicinal granules of powder of the present invention, wherein, the mass ratio of adjuvant cyclodextrin and maltodextrin is 3:2 ~ 7:3.
Further, a kind of Ganoderma spore medicinal granules of powder of the present invention, wherein, cyclodextrin is beta-schardinger dextrin-.
Further, a kind of Ganoderma spore medicinal granules of powder of the present invention, this electuary also comprises Fructus Crataegi, Fructus Hordei Germinatus (parched), and the mass percent of two kinds of compositions in electuary is respectively 1% ~ 3%.
The preparation method of Ganoderma spore medicinal granules of powder provided by the invention, comprises the following steps:
(1) Ganoderma spore powder with cellular wall broken is prepared as raw material, for subsequent use;
(2) take cyclodextrin and maltodextrin respectively, and using after the cyclodextrin after taking and maltodextrin Homogeneous phase mixing as adjuvant, the mass ratio of cyclodextrin and maltodextrin is 3:2 ~ 7:3;
(3) take stock and adjunct respectively, by raw material and adjuvant Homogeneous phase mixing, to be then sprayed in mixture with wetting agent and for subsequent use after stirring, the mass ratio of raw material and adjuvant is 1 ~ 3:3 ~ 5;
(4) mixture in step (3) is made granule, and be carry out dried under the condition of 60 DEG C in temperature by granule, then be that 20 ~ 100 object screen clothes screen by the granule after dried by order number, finally the material after screening carried out vacuum packaging and obtain finished product.
Further, the preparation method of Ganoderma spore medicinal granules of powder provided by the invention, wherein, in described step (1), the concrete grammar preparing Ganoderma spore powder with cellular wall broken is:
1. use lywallzyme to be Ganoderma spore of degrading under the condition of 20 ~ 50 DEG C in temperature, obtain degradation solution;
2. to step 1. in the degradation solution that obtains carry out freezing, melt processed successively, and process 2 ~ 5 times continuously;
3. under maintaining the temperature at the condition of 20 ~ 50 DEG C, carry out ultrasonication process to the degradation solution after 2. processing through step, the degradation solution after fragmentation obtains Ganoderma spore powder with cellular wall broken after the drying baker of 60 DEG C carries out dried.
Further, the preparation method of Ganoderma spore medicinal granules of powder provided by the invention, wherein, described step 1. in, lywallzyme is one or more the mixture in lysozyme, Snailase, cellulase, hemicellulase.
Further, the preparation method of Ganoderma spore medicinal granules of powder provided by the invention, wherein, in described step (3), wetting agent is the ethanol of 60% ~ 80%.
Further, the preparation method of Ganoderma spore medicinal granules of powder provided by the invention, wherein, when this electuary also comprises Fructus Crataegi, Fructus Hordei Germinatus (parched), described step (3) is: take Fructus Crataegi, Fructus Hordei Germinatus (parched), raw material and adjuvant respectively, Fructus Crataegi, Fructus Hordei Germinatus (parched) are obtained pressed powder after carrying out co-grinding process, and by pressed powder and raw material, adjuvant Homogeneous phase mixing, then be sprayed in mixture with wetting agent, for subsequent use after stirring, the mass ratio of raw material and adjuvant is 1 ~ 3:3 ~ 5, and Fructus Crataegi, the Fructus Hordei Germinatus (parched) mass percent in electuary is 1% ~ 3%.
Further, the preparation method of Ganoderma spore medicinal granules of powder provided by the invention, wherein, concrete grammar Fructus Crataegi, Fructus Hordei Germinatus (parched) being carried out to co-grinding process is: first, mix homogeneously after Fructus Crataegi, Fructus Hordei Germinatus (parched) being cleaned, adds the water of solid amount 3 times, boils 3 times, then, after 100 object screen filtrations, by filtrate evaporate to dryness, the solids of acquisition, finally, the pressed powder of Fructus Crataegi and Fructus Hordei Germinatus (parched) is obtained after being pulverized by solids.
The present invention compared with prior art has following beneficial effect: Ganoderma spore medicinal granules of powder provided by the invention overcomes the blank of not relevant Ganoderma spore medicinal granules of powder in prior art, the application solving Ganoderma spore powder in prior art is just drinkable after needing to form decoction with decoction method, carries and drink all inconvenient technical problem.Ganoderma spore medicinal granules of powder of the present invention can direct taking medicine after mixing with water, and electuary Raw and adjuvant complement each other, and are conducive to the abundant absorption of nutritional labeling and ingredient.Raw material adopts Ganoderma spore powder with cellular wall broken, after its effective ingredient is fully absorbed by human body, has the health-care effect of enhancing immunity, is applicable to immunocompromised person and uses, also have the health-care effects such as adjusting immunity of human body function, Tumor suppression, slow down aging; Cyclodextrin in adjuvant and maltodextrin can make electuary have good moisture resistance and melting, have good granularity, bulk density and mobility simultaneously, are conducive to production, subpackage and storage.The preparation method of Ganoderma spore medicinal granules of powder provided by the invention have technique simple, implement the feature that is easy to, be conducive to large-scale production.
Detailed description of the invention
First it should be noted that, this invention provides both a kind of Ganoderma spore medicinal granules of powder, further provide the preparation method of this Ganoderma spore medicinal granules of powder.For ease of statement, by way of example the present invention is described in further detail respectively below.
Embodiment 1, a kind of Ganoderma spore medicinal granules of powder provided by the invention, this electuary comprises stock and adjunct, and the mass ratio of raw material and adjuvant is 1:3, and raw material is Ganoderma spore powder with cellular wall broken, and adjuvant is the mixture of cyclodextrin and maltodextrin.
Embodiment 2, a kind of Ganoderma spore medicinal granules of powder provided by the invention, this electuary comprises stock and adjunct, and the mass ratio of raw material and adjuvant is 1:2, and raw material is Ganoderma spore powder with cellular wall broken, and adjuvant is the mixture of cyclodextrin and maltodextrin.
Embodiment 3, a kind of Ganoderma spore medicinal granules of powder provided by the invention, this electuary comprises stock and adjunct, and the mass ratio of raw material and adjuvant is 3:5, and raw material is Ganoderma spore powder with cellular wall broken, and adjuvant is the mixture of cyclodextrin and maltodextrin.
From above-described embodiment, the adjuvant of a kind of Ganoderma spore medicinal granules of powder of the present invention adopts the mixture of cyclodextrin and maltodextrin, the granule obtained can be made to have good moisture resistance and melting, there is good granularity, bulk density and mobility simultaneously, the requirement of production, subpackage and storage can be met; Raw material adopts Ganoderma spore powder with cellular wall broken, after electuary of directly taking after mixing it with water is drunk, is convenient to the abundant absorption of human body to Ganoderma spore powder.To learn in conjunction with the dose that patient can take through test of many times, when a kind of raw material of Ganoderma spore medicinal granules of powder of the present invention and the mass ratio of adjuvant are set as 1 ~ 3:3 ~ 5, granulation requirement can be met, the content of Ganoderma spore powder with cellular wall broken medicinal ingredient can be improved again to greatest extent, thus ensure drug effect.Further preferably, under the prerequisite of satisfied requirement of granulating, the mass ratio of raw material and adjuvant is set as that 1:2 is the most suitable by the present invention.
Typically, Ganoderma spore powder with cellular wall broken is compared with not Ganoderma spore powder with cellular wall broken, in Ganoderma spore powder with cellular wall broken, the content of Ganoderma albumen, polysaccharide, triterpene isoreactivity composition is higher, cyclodextrin in the present invention in adjuvant and maltodextrin have the moisture resistance of enhancing electuary granule and the effect of melting, in electuary taking medicine after mixing with water process, raw material and adjuvant complement each other, and are conducive to the abundant absorption of human body to nutritional labeling and ingredient.
Embodiment 4, a kind of Ganoderma spore medicinal granules of powder provided by the invention, this electuary comprises stock and adjunct, and the mass ratio of raw material and adjuvant is 1 ~ 3:3 ~ 5, and raw material is Ganoderma spore powder with cellular wall broken, and adjuvant is cyclodextrin and maltodextrin mixture.For improve electuary granule formability, bulk density, angular stop, dissolve rate, hygroscopicity, number of bacteria etc., the mass ratio of cyclodextrin and maltodextrin is set as 3:2 ~ 7:3 by the present embodiment.Preferably, cyclodextrin adopts beta-schardinger dextrin-.
Experiment one: by following experiment, the impact of the different quality comparison electuary granular mass of checking adjuvant cyclodextrin and maltodextrin.
Based on the technical scheme that embodiment 4 provides, adjuvant is prepared successively according to the different quality ratio of following table (table one) cyclodextrin and maltodextrin, and quality testing is carried out to the electuary granule that adjuvant becomes with mixed raw material, quality testing comprises following several:
1. the mensuration of mouldability: weigh 30g electuary granule, is 20 ~ 100 object screen clothes by 30g electuary granule by order number, gathers sieve quantity and quantity of not sieving, weigh, repeat 3 times, granular mass × 100% before granular mass after using ratio of briquetting=sieve/sieve, calculates ratio of briquetting.
2. the mensuration of bulk density: adopt graduated cylinder method, weighs 20 grams of electuary granules, weighed granule is put into the graduated cylinder of drying, hand-held graduated cylinder is vertically dropped on plank by 5cm eminence, repeatedly measures particle volume after 5 times, then calculates bulk density, repeat 5 times.
3. the mensuration of angular stop: adopt fixed funnel method, 3 funnels are connected and is fixed on the At The Height of 1cm on the graph paper of horizontal positioned, carefully granule is poured into along hopper walls in the funnel gone up most, until the granule cone tips that graph paper is formed touches bell mouth, the diameter of conical base is measured by graph paper, calculate angular stop tga=H/R, repeat 5 times.
4. the mensuration of rate is dissolved: in the 5mL centrifuge tube (minimum scale 0.1mL) of dry constant weight, add accurately weighed electuary granule 1g, precision adds boiling water 5mL, stir vibration 5 minutes, 3000r/ minute centrifugal 15 minutes, abandon toward supernatant, at 80 DEG C, residue is dried to constant weight, accurately weighed, rate is dissolved in calculating, dissolves rate=dissolve granular mass/granular mass × 100%.
5. hygroscopic mensuration: get a certain amount of extract powder, to put in 30 DEG C of baking ovens constant weight 48 hours.Bottom is placed with timing in the glass desicator of NaCl saturated solution and puts NaCl into until form NaCl supersaturated solution, the relative humidity now in exsiccator is 75%.Bottom the flat weighing botle of constant weight, put into electuary granule, correctly weigh and be placed in above-mentioned exsiccator.Weigh after 48 hours, calculate moisture absorption percentage.
6. the mensuration of number of bacteria: get 1g electuary granule, preparation 10ml solution, dilutes 10 times, serial dilution 4 times, cultivation, microscopy, statistics colony count successively.
Respectively quality testing is carried out to the electuary granule that cyclodextrin and the maltodextrin preparation of different quality ratio are formed by said method, detects data as shown in following table (table one):
Drawn by above table: 1. electuary grain forming rate increases along with the ratio of cyclodextrin and maltodextrin, ratio of briquetting is in downward trend after first raising, and when ratio is 7:3, ratio of briquetting reaches maximum 95%.Maltodextrin is more sticky, and cyclodextrin loosely, when the ratio of maltodextrin reaches 80% ~ 100%, due to too sticky, does not become granule; When the ratio of cyclodextrin reaches more than 90%, due to cyclodextrin loosely, granule is very easily broken, and in the industry, grain forming rate standard gauge is decided to be > 85%, therefore, reaches and all can reach standard when proportioning is 3:2 ~ 7:3.2. along with the ratio of cyclodextrin and maltodextrin increases, bulk density is in downward trend gradually, and in the industry, bulk density standard gauge is decided to be 200 ~ 600kg/m
3, therefore, except≤1:4, other proportionings are all up to standard.3. along with the ratio of cyclodextrin and maltodextrin increases, angular stop is in the trend increased afterwards that first diminishes, when ratio is 7:3 and 4:1, angular stop is minimum, and angular stop less explanation particle surface is more smooth, good fluidity when it is generally acknowledged angular stop tg α=0.577 (30 °), the demand of mobility in production process can be met when th α=0.839 (40 °), and the data th α of this experiment be all less than=0.577, therefore, angular stop all reaches requirement.4. data display adjuvant all melts (adjuvant: Ganoderma spore powder is 1 ~ 3:3 ~ 5), and spore powder slight haze, reaches the requirement of the rate of dissolving substantially.5. hydroscopicity standard gauge be decided to be≤6%, data display be all significantly less than 6%, therefore, hydroscopicity is all up to standard.6. Health Regulations antibacterial standard is≤10000/g, and data display number of bacteria is well below standard, and therefore, product number of bacteria all meets hygienic requirements.
As can be seen here, according to above-mentioned experimental result, due to granule preparation easy moisture absorption in production and storage process, mainly adopt and take after mixing it with water, so the moisture resistance of adjuvant and melting most important, this experimental study shows: the mass ratio of adjuvant cyclodextrin and maltodextrin is set to 3:2 ~ 7:3, and obtained granule has good moisture resistance and melting, there are good granularity, bulk density and mobility simultaneously, can meet and produce subpackage and shelf appeal.
Embodiment 5, a kind of Ganoderma spore medicinal granules of powder provided by the invention, this electuary comprises stock and adjunct, and the mass ratio of raw material and adjuvant is 1 ~ 3:3 ~ 5, and raw material is Ganoderma spore powder with cellular wall broken, and adjuvant is the mixture of cyclodextrin and maltodextrin.For improve electuary granule formability, bulk density, angular stop, dissolve rate, hygroscopicity, number of bacteria etc., the mass ratio that the present embodiment further defines cyclodextrin and maltodextrin is 3:2 ~ 7:3.Further, this electuary also comprises Fructus Crataegi, Fructus Hordei Germinatus (parched), and the mass percent of two kinds of compositions in electuary is respectively 1%.Preferably, cyclodextrin adopts beta-schardinger dextrin-.
Embodiment 6, a kind of Ganoderma spore medicinal granules of powder provided by the invention, this electuary comprises stock and adjunct, and the mass ratio of raw material and adjuvant is 1 ~ 3:3 ~ 5, and raw material is Ganoderma spore powder with cellular wall broken, and adjuvant is the mixture of cyclodextrin and maltodextrin.For improve electuary granule formability, bulk density, angular stop, dissolve rate, hygroscopicity, number of bacteria etc., the mass ratio that the present embodiment further defines cyclodextrin and maltodextrin is 3:2 ~ 7:3.Further, this electuary also comprises Fructus Crataegi, Fructus Hordei Germinatus (parched), and the mass percent of two kinds of compositions in electuary is respectively 2%.Preferably, cyclodextrin is beta-schardinger dextrin-.
Embodiment 7, the invention provides a kind of Ganoderma spore medicinal granules of powder, this electuary comprises stock and adjunct, and the mass ratio of raw material and adjuvant is 1 ~ 3:3 ~ 5, and raw material is Ganoderma spore powder with cellular wall broken, and adjuvant is the mixture of cyclodextrin and maltodextrin.For improve electuary granule formability, bulk density, angular stop, dissolve rate, hygroscopicity, number of bacteria etc., the mass ratio that the present embodiment further defines cyclodextrin and maltodextrin is 3:2 ~ 7:3.Further, this electuary also comprises Fructus Crataegi, Fructus Hordei Germinatus (parched), and the mass percent of two kinds of compositions in electuary is respectively 3%.Preferably, cyclodextrin is beta-schardinger dextrin-.
Fructus Crataegi has very high nutritive value and medical value, and old people often eats haw products energy appetite strengthening, improving water flood, and keep the constant of calcium in skeleton and blood, prevention of arterial is atherosis; Fructus Hordei Germinatus (parched) is used for dispersing the stagnated live-QI to relieve the stagnation of QI, for the hypochondriac pain, abdominal pain etc. of irritability stasis or incoordination between the liver and stomach.Fructus Crataegi and Fructus Hordei Germinatus (parched) and Ganoderma spore powder with cellular wall broken can complement each other, and are easy to absorb, and have the health-care effect of enhancing immunity, are applicable to immunocompromised person and use, have the health-care effects such as adjusting immunity of human body function, Tumor suppression, slow down aging.
Embodiment 8, the preparation method of a kind of Ganoderma spore medicinal granules of powder provided by the invention, specifically comprises the following steps:
(1) Ganoderma spore powder with cellular wall broken is prepared as raw material, for subsequent use; Further, the concrete grammar preparing Ganoderma spore powder with cellular wall broken is:
1. use lywallzyme to be Ganoderma spore of degrading under the condition of 20 ~ 50 DEG C in temperature, obtain degradation solution; Lywallzyme adopts one or more the mixture in lysozyme, Snailase, cellulase, hemicellulase;
2. to step 1. in the degradation solution that obtains carry out freezing, melt processed successively, and process 2 ~ 5 times continuously;
3. under maintaining the temperature at the condition of 20 ~ 50 DEG C, carry out ultrasonication process to the degradation solution after 2. processing through step, the degradation solution after fragmentation obtains Ganoderma spore powder with cellular wall broken after the drying baker of 60 DEG C carries out dried;
(2) take cyclodextrin and maltodextrin respectively, and using after the cyclodextrin after taking and maltodextrin Homogeneous phase mixing as adjuvant, the mass ratio of cyclodextrin and maltodextrin is 3:2 ~ 7:3;
(3) take stock and adjunct respectively, by raw material and adjuvant Homogeneous phase mixing, to be then sprayed in mixture with wetting agent and for subsequent use after stirring, the mass ratio of raw material and adjuvant is 1 ~ 3:3 ~ 5; Further, the wetting agent that this step uses is the ethanol of 60% ~ 80%.
(4) mixture in step (3) is made granule, and be carry out dried under the condition of 60 DEG C in temperature by granule, then be that 20 ~ 100 object screen clothes screen by the granule after dried by order number, finally the material after screening carried out vacuum packaging and obtain finished product.
Embodiment 9, the preparation method of a kind of Ganoderma spore medicinal granules of powder provided by the invention, specifically comprises the following steps:
(1) Ganoderma spore powder with cellular wall broken is prepared as raw material, for subsequent use; Further, the concrete grammar preparing Ganoderma spore powder with cellular wall broken is:
1. use lywallzyme to be Ganoderma spore of degrading under the condition of 20 ~ 50 DEG C in temperature, obtain degradation solution; Lywallzyme adopts one or more the mixture in lysozyme, Snailase, cellulase or hemicellulase;
2. to step 1. in the degradation solution that obtains carry out freezing, melt processed successively, and process 2 ~ 5 times continuously;
3. under maintaining the temperature at the condition of 20 ~ 50 DEG C, carry out ultrasonication process to the degradation solution after 2. processing through step, the degradation solution after fragmentation obtains Ganoderma spore powder with cellular wall broken after the drying baker of 60 DEG C carries out dried;
(2) take cyclodextrin and maltodextrin respectively, and using after the cyclodextrin after taking and maltodextrin Homogeneous phase mixing as adjuvant, the mass ratio of cyclodextrin and maltodextrin is 3:2 ~ 7:3;
(3) when this electuary also comprises Fructus Crataegi, Fructus Hordei Germinatus (parched), take Fructus Crataegi, Fructus Hordei Germinatus (parched), raw material and adjuvant respectively, Fructus Crataegi, Fructus Hordei Germinatus (parched) are obtained pressed powder after carrying out co-grinding process, and by pressed powder and raw material, adjuvant Homogeneous phase mixing, then be sprayed in mixture with wetting agent, for subsequent use after stirring, the mass ratio of raw material and adjuvant is 1 ~ 3:3 ~ 5, and Fructus Crataegi, the Fructus Hordei Germinatus (parched) mass percent in electuary is 1% ~ 3%; Further, concrete grammar Fructus Crataegi, Fructus Hordei Germinatus (parched) being carried out to co-grinding process is: first, mix homogeneously after Fructus Crataegi, Fructus Hordei Germinatus (parched) being cleaned, adds the water of solid amount 3 times, boils 3 times, then, after 100 object screen filtrations, by filtrate evaporate to dryness, the solids of acquisition, finally, the pressed powder of Fructus Crataegi and Fructus Hordei Germinatus (parched) is obtained after being pulverized by solids.
(4) mixture in step (3) is made granule, and be carry out dried under the condition of 60 DEG C in temperature by granule, then be that 20 ~ 100 object screen clothes screen by the granule after dried by order number, finally the material after screening carried out vacuum packaging and obtain finished product.
Experiment two: by following experiment, verifies that ganoderma lucidium spore powder wall breaking is from broken wall treatment mode is not different, on the impact of active component in electuary granule.
By above-mentioned preparation method, respectively use Ganoderma spore powder with cellular wall broken and not Ganoderma spore powder with cellular wall broken make electuary granule as raw material, respectively Ganoderma albumen, ganoderan, Ganoderma triterpenoids isoreactivity composition in granule are carried out detection and are analyzed, detect data as shown in following table (table two):
| Spore powder processing mode | Ganoderma albumen (mg/ml) | Ganoderan (mg/ml) | Ganoderma triterpenoids (mg/ml) |
| Not breaking cellular wall | 0.025bB | 0.31bB | 0.32bB |
| Breaking cellular wall | 0.079aA | 0.39aA | 0.38aA |
From tables of data, content containing Ganoderma albumen, ganoderan, Ganoderma triterpenoids three kinds of active component in Ganoderma spore powder with cellular wall broken is all higher than not Ganoderma spore powder with cellular wall broken, and there is pole significant difference, mainly due to the cell wall rich cellulose, chitin etc. of Ganoderma spore, complex structure, and acid and alkali-resistance, hinder the release of active substance, breaking trachytectum of glossy ganoderma process is conducive to the stripping of the effective ingredient such as Ganoderma triterpenoids in Ganoderma spore powder, ganoderan and Ganoderma albumen, adds the probability that human body absorbs above-mentioned substance and utilizes.
In addition, the concrete wall-breaking method of Ganoderma spore powder provided by the invention, wall-breaking method is simple, convenient operation, there is following defect in Mechanical Crushing of the prior art: the rising of food and the surface area contacted increase of canister and temperature all can increase material stripping in rustless steel container, if under the spore powder after breaking cellular wall is exposed to the environment of aerobic, can there is autoxidation in its unsaturated fatty acid contained on the one hand, produce peroxide and be then degraded into volatile aldehyde, the complex mixture of ketone and acid, microorganism on the other hand in air can be decomposed into free fatty and glycerol oils and fats, these fatty acids can produce volatile lower ketones through serial enzymatic reaction, glycerol then can be oxidized to has 1 of foreign odor, 2-epoxy propionic aldehyde, these harmful substances can destroy other effective ingredient in spore powder, have a strong impact on the quality of spore powder and then harm is produced to the health of people, this wall-breaking method is simple to operate, convenient operation.
Experiment three: by following experiment, verify that different alcohol concentration is on the impact of electuary granular mass in Ganoderma spore medicinal granules of powder preparation method.
According to the preparation method of the Ganoderma spore medicinal granules of powder that embodiment 8 and 9 provides, the alcohol of choice for use variable concentrations is for electuary granule successively, and carries out quality testing to electuary granule respectively, and quality testing comprises following several (table three):
Learnt by above-mentioned tables of data, 1. along with the increase of alcohol concentration, ratio of briquetting is in first raising rear downward trend, when alcohol concentration is 60%, ratio of briquetting reaches maximum 95%, grain forming rate standard gauge is decided to be > 85%, therefore, when alcohol concentration is 60% ~ 80%, ratio of briquetting all reaches standard.2. the increase of alcohol concentration, bulk density is in the trend risen that declines gradually, and the ethanol of high concentration makes particle viscosity increase, and minima is 443.5kg/m
3, maximum is 501.3kg/m
3, and bulk density is all up to standard, and (standard gauge is decided to be 200 ~ 600kg/m
3).3. the increase of alcohol concentration, angular stop is in the trend increased, and angular stop minima is 0.42, and maximum is 0.49, and therefore, angular stop all reaches requirement (standard th α≤0.839 (40 °)).4. along with the increase of alcohol concentration, adjuvant all melts, spore powder slight haze, substantially reaches the requirement of the rate of dissolving; 5. hydroscopicity standard gauge be decided to be≤6%, data display maximum be 1.3%, far below standard value, therefore, hydroscopicity all reaches standard.6. Health Regulations antibacterial standard is≤10000/g, and ethanol has bactericidal action, and data show process number of bacteria used all well below standard, and therefore, product number of bacteria all meets hygienic requirements.
As can be seen here, according to above-mentioned experimental result and data analysis, when alcohol concentration is 60% ~ 80%, its viscosity is applicable to Ganoderma spore powder and granulates, and granulate and more meet the requirements, therefore the preferred wetting agent of the present invention is the ethanol of 60% ~ 80%.
Ganoderma spore medicinal granules of powder provided by the invention strictly controls each step in preparation method, comprise the drying to composition, mixing, pulverizing etc., each stage is checked on, overall process is strictly monitored, in addition, electuary curative effect key is just the content of the ganoderma active material often contained by bag electuary, only has content to reach standard, the drug effect of its application of competence exertion.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a Ganoderma spore medicinal granules of powder, is characterized in that, this electuary comprises stock and adjunct, and the mass ratio of raw material and adjuvant is 1 ~ 3:3 ~ 5, and raw material is Ganoderma spore powder with cellular wall broken, and adjuvant is the mixture of cyclodextrin and maltodextrin.
2. Ganoderma spore medicinal granules of powder according to claim 1, is characterized in that, the mass ratio of described adjuvant cyclodextrin and maltodextrin is 3:2 ~ 7:3.
3. Ganoderma spore medicinal granules of powder according to claim 1, is characterized in that, described cyclodextrin is beta-schardinger dextrin-.
4. Ganoderma spore medicinal granules of powder according to claim 1, is characterized in that, this electuary also comprises Fructus Crataegi, Fructus Hordei Germinatus (parched), and the mass percent of two kinds of compositions in electuary is respectively 1% ~ 3%.
5. a preparation method for Ganoderma spore medicinal granules of powder described in claim 1, it is characterized in that, the method comprises the following steps:
(1) Ganoderma spore powder with cellular wall broken is prepared as raw material, for subsequent use;
(2) take cyclodextrin and maltodextrin respectively, and using after the cyclodextrin after taking and maltodextrin Homogeneous phase mixing as adjuvant, the mass ratio of cyclodextrin and maltodextrin is 3:2 ~ 7:3;
(3) take stock and adjunct respectively, by raw material and adjuvant Homogeneous phase mixing, to be then sprayed in mixture with wetting agent and for subsequent use after stirring, the mass ratio of raw material and adjuvant is 1 ~ 3:3 ~ 5;
(4) mixture in step (3) is made granule, and be carry out dried under the condition of 60 DEG C in temperature by granule, then be that 20 ~ 100 object screen clothes screen by the granule after dried by order number, finally the material after screening carried out vacuum packaging and obtain finished product.
6. the preparation method of Ganoderma spore medicinal granules of powder according to claim 5, is characterized in that, in described step (1), the concrete grammar preparing Ganoderma spore powder with cellular wall broken is:
1. use lywallzyme to be Ganoderma spore of degrading under the condition of 20 ~ 50 DEG C in temperature, obtain degradation solution;
2. to step 1. in the degradation solution that obtains carry out freezing, melt processed successively, and process 2 ~ 5 times continuously;
3. under maintaining the temperature at the condition of 20 ~ 50 DEG C, carry out ultrasonication process to the degradation solution after 2. processing through step, the degradation solution after fragmentation obtains Ganoderma spore powder with cellular wall broken after the drying baker of 60 DEG C carries out dried.
7. the preparation method of Ganoderma spore medicinal granules of powder according to claim 6, is characterized in that, described step 1. in, lywallzyme is one or more the mixture in lysozyme, Snailase, cellulase, hemicellulase.
8. the preparation method of Ganoderma spore medicinal granules of powder according to claim 5, is characterized in that, in described step (3), wetting agent is the ethanol of 60% ~ 80%.
9. the preparation method of Ganoderma spore medicinal granules of powder according to claim 5, it is characterized in that, when this electuary also comprises Fructus Crataegi, Fructus Hordei Germinatus (parched), described step (3) is: take Fructus Crataegi, Fructus Hordei Germinatus (parched), raw material and adjuvant respectively, Fructus Crataegi, Fructus Hordei Germinatus (parched) are obtained pressed powder after carrying out co-grinding process, and by pressed powder and raw material, adjuvant Homogeneous phase mixing, then be sprayed in mixture with wetting agent, for subsequent use after stirring, the mass ratio of raw material and adjuvant is 1 ~ 3:3 ~ 5, and Fructus Crataegi, the Fructus Hordei Germinatus (parched) mass percent in electuary is 1% ~ 3%.
10. the preparation method of Ganoderma spore medicinal granules of powder according to claim 9, it is characterized in that, concrete grammar Fructus Crataegi, Fructus Hordei Germinatus (parched) being carried out to co-grinding process is: first, mix homogeneously after Fructus Crataegi, Fructus Hordei Germinatus (parched) being cleaned, add the water of solid amount 3 times, boil 3 times, then, after 100 object screen filtrations, by filtrate evaporate to dryness, the solids obtained, finally, obtains the pressed powder of Fructus Crataegi and Fructus Hordei Germinatus (parched) after being pulverized by solids.
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