CN104922167B - A kind of Reishi sporule medicinal granules of powder and preparation method thereof - Google Patents
A kind of Reishi sporule medicinal granules of powder and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Reishi sporule medicinal granules of powder, which includes raw material and auxiliary material, and the mass ratio of raw material and auxiliary material is 1~3:3~5, raw material is ganoderma spove powder, and auxiliary material is the mixture of cyclodextrin and maltodextrin；Reishi sporule medicinal granules of powder preparation method disclosed by the invention is：Ganoderma spove powder is prepared as raw material；Cyclodextrin and maltodextrin are weighed respectively, and regard the cyclodextrin after weighing and maltodextrin as auxiliary material after evenly mixing；Raw material and auxiliary material are weighed respectively, and raw material is uniformly mixed with auxiliary material, is then sprayed in mixture with wetting agent, is stirred evenly rear spare；Mixture is made particle, and particle is dried under conditions of temperature is 60 DEG C, after final granule by mesh number is the sieve of 20~100 mesh, vacuum packaging obtains finished product.The present invention is easy to carry, can direct taking medicine after mixing with water, each ingredient complements each other in electuary, is easy to absorb, and preparation method is simple, is convenient for use of large-scale production, the healthcare function with strengthen immunity.
Description
Technical field
The present invention relates to a kind of Chinese herbal and crude drugs preparations, in particular to a kind of Reishi sporule medicinal granules of powder and the ganoderma lucidum spore
The preparation method of sub- medicinal granules of powder.
Background technology
Lucidum spore powder contains a variety of active ingredients such as ganoderma lucidum albumen, polysaccharide, triterpene, with antitumor, protecting liver and detoxication, in advance
Anti- angiocardiopathy, antiallergy, anti-aging, neurasthenia, the works such as treatment hypertension, chronic bronchitis, bronchial asthma
With especially having an obvious inhibiting effect to kinds of tumor cells, radiotherapy of the cooperation for malignant tumor patient, chemotherapy can enhance
The tolerance of patient mitigates side effect, improves hemopoietic function of bone marrow, increases transfer, the recurrence of leucocyte, enhances immunocompetence,
Patient with advanced cancer can build up health after taking and anti-cancer ability, alleviates the occurrence and development of complication, extends survival period.
In addition to medical application, lucidum spore powder the industries such as food, drink and health products also occupy certain market with
Status has higher economic value.Lucidum spore powder is both different from therapeutic effect of the general drug to certain disease, also different
Only the deficiency of nutrient in a certain respect is supplemented and strengthened in general nutritional health food, its unique distinction essentially consists in
It bidirectional modulation function of human body can balance on the whole, transfer internal body vigor, adjust human metabolism, improve autoimmunity
Ability promotes whole internal organ or organ function normalization, to fundamentally achieve the purpose that health care of promoting health and curing diseases.
Currently, for lucidum spore powder application still need with decoction method formed decoction of medicinal ingredients after just can be used, carry and
Drink equal inconvenience.Although domestic and foreign scholars have carried out the research to different instant particles as Chinese medicine particles, and obtain certain achievement,
Such as, fresh rehmannia root Compatible Granule, Astragalus granules, permanently happy granule, male Chinese herbaceous peony granule, control strongly fragrant particle, Radix Isatidis granule
Deng because this electuary has many advantages, such as to exempt to decoct, portable, convenient to take, receiving doctors and patients' favor.But up to the present, about spirit
The development of Ganoderma lucidum spore medicinal granules of powder does not report that the research for Reishi sporule medicinal granules of powder still falls within the market vacancy, therefore, such as also
What solve lucidum spore powder because not Portable belt, drink due to limit its application, be that the current field needs the problem solved.
Invention content
The object of the present invention is to provide a kind of Reishi sporule medicinal granules of powder and preparation method thereof, which has
It is easy to carry, can direct taking medicine after mixing with water the advantages of, the preparation method of the Reishi sporule medicinal granules of powder have it is simple for process, implement to be easy
The characteristics of.
Ability is drinkable after application needs to solve lucidum spore powder in the prior art form decoction of medicinal ingredients with decoction method, carries
With the technical problem for drinking equal inconvenience, the present invention provides a kind of Reishi sporule medicinal granules of powder and preparation method thereof, the ganoderma lucidum spores
Sub- medicinal granules of powder includes raw material and auxiliary material, and the mass ratio of raw material and auxiliary material is 1~3:3~5, raw material is ganoderma spove powder, auxiliary
Material is the mixture of cyclodextrin and maltodextrin.
Further, a kind of Reishi sporule medicinal granules of powder of the present invention, wherein the mass ratio of auxiliary material cyclodextrin and maltodextrin
It is 3:2~7:3.
Further, a kind of Reishi sporule medicinal granules of powder of the present invention, wherein cyclodextrin is beta-cyclodextrin.
Further, a kind of Reishi sporule medicinal granules of powder of the present invention, which further includes hawthorn, coloured malt, and two kinds of ingredients exist
Mass percent in electuary is respectively 1%~3%.
The preparation method of Reishi sporule medicinal granules of powder provided by the invention, includes the following steps：
(1) ganoderma spove powder is prepared as raw material, it is spare；
(2) cyclodextrin and maltodextrin are weighed respectively, and the cyclodextrin after weighing and maltodextrin are made after evenly mixing
For auxiliary material, the mass ratio of cyclodextrin and maltodextrin is 3:2~7:3；
(3) raw material and auxiliary material are weighed respectively, and raw material is uniformly mixed with auxiliary material, is then sprayed in mixture with wetting agent
And stirring evenly rear spare, the mass ratio of raw material and auxiliary material is 1~3:3~5；
(4) particle is made in the mixture in step (3), and place is dried under conditions of temperature is 60 DEG C in particle
Then reason is screened the particle after drying process by the sieve that mesh number is 20~100 mesh, finally by the pellet after screening
It is vacuum-packed to obtain finished product.
Further, the preparation method of Reishi sporule medicinal granules of powder provided by the invention, wherein in the step (1), system
It is for the specific method of ganoderma spove powder：
1. degrading Reishi sporule under conditions of temperature is 20~50 DEG C using lywallzyme, degradation solution is obtained；
2. to step 1. in the degradation solution that obtains freezed successively, melt processed, and continuous processing 2~5 times；
3. maintaining the temperature under conditions of 20~50 DEG C, to being carried out at ultrasonication through step 2. treated degradation solution
Reason, broken degradation solution obtain ganoderma spove powder after processing is dried in 60 DEG C of drying box.
Further, the preparation method of Reishi sporule medicinal granules of powder provided by the invention, wherein the step 1. in, it is molten
Wall enzyme is the mixture of one or more of lysozyme, glusulase, cellulase, hemicellulase.
Further, the preparation method of Reishi sporule medicinal granules of powder provided by the invention, wherein wet in the step (3)
Moisten the alcohol that agent is 60%~80%.
Further, the preparation method of Reishi sporule medicinal granules of powder provided by the invention, wherein when the electuary further includes mountain
When short, bristly hair or beard, coloured malt, the step (3) is：Hawthorn, coloured malt, raw material and auxiliary material are weighed respectively, and hawthorn, coloured malt are mixed
Solid powder is obtained after closing pulverization process, and solid powder is uniformly mixed with raw material, auxiliary material, is then sprayed to wetting agent mixed
It closes in object, stirs evenly rear spare, the mass ratio of raw material and auxiliary material is 1~3:3~5, the quality of hawthorn, coloured malt in electuary
Percentage is 1%~3%.
Further, the preparation method of Reishi sporule medicinal granules of powder provided by the invention, wherein hawthorn, coloured malt are carried out
Co-grinding processing specific method be：First, it is uniformly mixed after hawthorn, coloured malt being cleaned, 3 times of solid amount is added
Water is boiled 3 times, then, after the screen filtration by 100 mesh, filtrate is evaporated, the solids of acquisition, finally, by solids powder
The solid powder of hawthorn and coloured malt is obtained after broken.
The present invention has the advantages that compared with prior art：Reishi sporule medicinal granules of powder provided by the invention overcomes
In the prior art without the blank of related Reishi sporule medicinal granules of powder, solve lucidum spore powder in the prior art application need with
Ability is drinkable after decoction method forms decoction of medicinal ingredients, carries and drink the technical problem of equal inconvenience.The lucidum spore powder punching of the present invention
Agent can direct taking medicine after mixing with water, and raw material complements each other with auxiliary material in electuary, is conducive to the abundant of nutritional ingredient and drug ingedient
It absorbs.Raw material uses ganoderma spove powder, after active ingredient is fully absorbed by human body, the health care with strengthen immunity
Effect is suitble to immunocompromised person to use, and also has the function of to adjust body immunity, the health cares such as tumour, anti-aging is inhibited to make
With；Cyclodextrin in auxiliary material can make electuary have preferable moisture resistance and melting with maltodextrin, while have good
Granularity, heap density and mobility are conducive to production, packing and storage.The preparation side of Reishi sporule medicinal granules of powder provided by the invention
Method has the characteristics that simple for process, implementation is easy, and is conducive to mass produce.
Specific implementation mode
Firstly the need of explanation, this invention provides both a kind of Reishi sporule medicinal granules of powder, and provide the Reishi sporule
The preparation method of medicinal granules of powder.For ease of statement, present invention is further described in detail by way of examples separately below.
Embodiment 1, a kind of Reishi sporule medicinal granules of powder provided by the invention, the electuary include raw material and auxiliary material, raw material with it is auxiliary
The mass ratio of material is 1:3, raw material is ganoderma spove powder, and auxiliary material is the mixture of cyclodextrin and maltodextrin.
Embodiment 2, a kind of Reishi sporule medicinal granules of powder provided by the invention, the electuary include raw material and auxiliary material, raw material with it is auxiliary
The mass ratio of material is 1:2, raw material is ganoderma spove powder, and auxiliary material is the mixture of cyclodextrin and maltodextrin.
Embodiment 3, a kind of Reishi sporule medicinal granules of powder provided by the invention, the electuary include raw material and auxiliary material, raw material with it is auxiliary
The mass ratio of material is 3:5, raw material is ganoderma spove powder, and auxiliary material is the mixture of cyclodextrin and maltodextrin.
By above-described embodiment it is found that a kind of auxiliary material of Reishi sporule medicinal granules of powder of the present invention is using cyclodextrin and maltodextrin
Mixture can make particle obtained have preferable moisture resistance and melting, while have preferable granularity, heap density and stream
Dynamic property can meet the requirement of production, packing and storage；Raw material uses ganoderma spove powder, after electuary of directly taking after mixing it with water is drunk,
Lucidum spore powder is fully absorbed convenient for human body.The dose that can be taken by test of many times and in conjunction with patient learns, this hair
A kind of raw material of bright Reishi sporule medicinal granules of powder and the mass ratio of auxiliary material are set as 1~3:When 3~5, granulation can be met and required, again
The content that ganoderma spove powder medicinal ingredient can be improved to greatest extent, to ensure drug effect.It is further preferred that meeting
Under the premise of granulation requires, the mass ratio of raw material and auxiliary material is set as 1 by the present invention:2 is most appropriate.
Typically, ganoderma spove powder is compared with not ganoderma spove powder, ganoderma lucidum egg in ganoderma spove powder
In vain, polysaccharide, the content of triterpene isoreactivity ingredient are higher, and the cyclodextrin and maltodextrin in the present invention in auxiliary material have enhancing electuary
The effect of the moisture resistance and melting of particle, during electuary taking medicine after mixing with water, raw material complements each other with auxiliary material, is conducive to human body
Nutritional ingredient and drug ingedient are fully absorbed.
Embodiment 4, a kind of Reishi sporule medicinal granules of powder provided by the invention, the electuary include raw material and auxiliary material, raw material with it is auxiliary
The mass ratio of material is 1~3:3~5, raw material is ganoderma spove powder, and auxiliary material is cyclodextrin and maltodextrin mixture.To carry
The formability of high granule granule, angular stop, dissolves rate, hygroscopicity, number of bacteria etc. at heap density, the present embodiment by cyclodextrin and
The mass ratio of maltodextrin is set as 3:2~7:3.Preferably, cyclodextrin uses beta-cyclodextrin.
Experiment one：By following experiment, the different quality for verifying auxiliary material cyclodextrin and maltodextrin compares granule granule
The influence of quality.
Based on the technical solution that embodiment 4 provides, successively according to following table (table one) cyclodextrin and maltodextrin
Different quality ratio carries out quality testing, quality testing packet to prepare auxiliary material to the granule granule that auxiliary material and raw material are mixed
It includes following several：
1. the measurement of mouldability：Weigh 30g granule granules, by 30g granule granules by mesh number be 20~100 mesh sieve
Net, acquisition sieving quantity and quantity of not being sieved, weigh, are repeated 3 times, use before granular mass/sieving after ratio of briquetting=sieving
Grain quality × 100%, to calculate ratio of briquetting.
2. the measurement of heap density：Using graduated cylinder method, 20 grams of granule granules are weighed, weighed particle is put into dry graduated cylinder
In, hand-held graduated cylinder is vertically fallen on plank by 5cm eminences, is measured particle volume after 5 times repeatedly, is then calculated heap density, repeat 5
It is secondary.
3. the measurement of angular stop：Using fixed funnel method, 3 funnels are connected and are fixed on horizontal positioned graph paper
At the height of 1cm, carefully particle is poured into along hopper walls in the funnel on most, until the particle cone formed on graph paper
Until nib contacts to bell mouth, the diameter of conical base is measured by graph paper, is calculated angular stop tga=H/R, is repeated 5 times.
4. dissolving the measurement of rate：Accurately weighed rush is added in the 5mL centrifuge tubes (minimum scale 0.1mL) of dry constant weight
Agent particle 1g, precision add boiling water 5mL, and stirring oscillation 5 minutes is centrifuged 15 minutes, abandoned toward supernatant, at 80 DEG C for 3000r/ minutes
By residue, drying to constant weight, accurately weighed, and rate is dissolved in calculating, dissolves rate=dissolve granular mass/granular mass × 100%.
5. hygroscopic measurement：A certain amount of extract powder is taken, constant weight 48 hours in 30 DEG C of baking ovens are set.Bottom is placed with NaCl
Periodically put into the glass desicator of saturated solution NaCl until formed NaCl supersaturated solutions, it is relatively wet in drier at this time
Degree is 75%.It is put into granule granule in the flat measuring cup bottom of constant weight, correctly weighs and is placed in above-mentioned drier.48 hours
After weigh, calculate moisture absorption percentage.
6. the measurement of number of bacteria：1g granule granules are taken, 10ml solution is prepared, successively 10 times of dilution, serial dilution 4 times,
Culture, microscopy, statistics colony count.
By the above method respectively to different quality than cyclodextrin and maltodextrin prepare the granule granule to be formed and carry out
Quality testing, shown in detection data such as following table (table one)：
It is obtained by above table：1. granule granule ratio of briquetting increases with the ratio of cyclodextrin and maltodextrin, ratio of briquetting
In downward trend after first increasing, when ratio is 7:Ratio of briquetting reaches maximum value 95% when 3.Maltodextrin is relatively viscous, cyclodextrin compared with
Loosely, when the ratio of maltodextrin is up to 80%~100%, due to too viscous, not at particle；When cyclodextrin ratio up to 90% with
When upper, loosely due to cyclodextrin, particle is easily broken, and grain forming rate standard is defined as ＞ 85% in the industry, therefore, matches
Than being 3:2~7:Standard can be reached by reaching when 3.2. with the ratio of cyclodextrin and maltodextrin increase, heap density be in by
Gradually downward trend, heap density criterion is defined as 200~600kg/m in the industry3, therefore, remove≤1:Other than 4, other proportionings
It is up to standard.3. as the ratio of cyclodextrin and maltodextrin increases, angular stop is in increased trend after first becoming smaller, when ratio is 7:
3 and 4:When 1, angular stop is minimum, and angular stop is smaller to illustrate that particle surface is more smooth, it is considered that α=0.577 angular stop tg
Good fluidity when (30 °), can meet the needs of mobility in production process when α=0.839 th (40 °), and the number of this experiment
It is respectively less than=0.577 according to th α, therefore, angular stop reaches requirement.4. data show that auxiliary material all melts (auxiliary material：Reishi sporule
Powder is 1~3:3~5), conidia powder slight turbid basically reaches the requirement for the rate of dissolving.5. hydroscopicity standard is defined as≤6%, number
It is significantly less than 6% according to display, therefore, hydroscopicity is up to standard.6. Health Regulations bacterium standard is≤10000/g, data are aobvious
Show number of bacteria well below standard, therefore, product number of bacteria meets hygienic requirements.
It can be seen that according to above-mentioned experimental result, since granule preparation is easy the moisture absorption during producing and storing,
Mainly using taking after mixing it with water, so the moisture resistance and melting of auxiliary material are most important, this experimental study shows：By auxiliary material cyclodextrin
It is set as 3 with the mass ratio of maltodextrin:2~7:3, particle obtained has good moisture resistance and melting, while having good
Granularity, heap density and mobility, can meet production packing and shelf appeal.
Embodiment 5, a kind of Reishi sporule medicinal granules of powder provided by the invention, the electuary include raw material and auxiliary material, raw material with it is auxiliary
The mass ratio of material is 1~3:3~5, raw material is ganoderma spove powder, and auxiliary material is the mixture of cyclodextrin and maltodextrin.For
It improves the formability of granule granule, heap density, angular stop, dissolve rate, hygroscopicity, number of bacteria etc., the present embodiment further limits
The mass ratio for having determined cyclodextrin and maltodextrin is 3:2~7:3.Further, which further includes hawthorn, coloured malt, two kinds
Mass percent of the ingredient in electuary is respectively 1%.Preferably, cyclodextrin uses beta-cyclodextrin.
Embodiment 6, a kind of Reishi sporule medicinal granules of powder provided by the invention, the electuary include raw material and auxiliary material, raw material with it is auxiliary
The mass ratio of material is 1~3:3~5, raw material is ganoderma spove powder, and auxiliary material is the mixture of cyclodextrin and maltodextrin.For
It improves the formability of granule granule, heap density, angular stop, dissolve rate, hygroscopicity, number of bacteria etc., the present embodiment further limits
The mass ratio for having determined cyclodextrin and maltodextrin is 3:2~7:3.Further, which further includes hawthorn, coloured malt, two kinds
Mass percent of the ingredient in electuary is respectively 2%.Preferably, cyclodextrin is beta-cyclodextrin.
Embodiment 7, the present invention provides a kind of Reishi sporule medicinal granules of powder, which includes raw material and auxiliary material, raw material with it is auxiliary
The mass ratio of material is 1~3:3~5, raw material is ganoderma spove powder, and auxiliary material is the mixture of cyclodextrin and maltodextrin.For
It improves the formability of granule granule, heap density, angular stop, dissolve rate, hygroscopicity, number of bacteria etc., the present embodiment further limits
The mass ratio for having determined cyclodextrin and maltodextrin is 3:2~7:3.Further, which further includes hawthorn, coloured malt, two kinds
Mass percent of the ingredient in electuary is respectively 3%.Preferably, cyclodextrin is beta-cyclodextrin.
Hawthorn has very high nutritive value and medical value, the elderly often to eat haw products and can whet the appetite, and improves sleep,
Keep constant, the prevention of arterial atherosis of calcium in bone and blood；Coloured malt is used for soothing liver-qi stagnation, is used for irritability stasis or liver
Hypochondriac pain, abdominal pain of stomach discord etc..Hawthorn and coloured malt can complement each other with ganoderma spove powder, are easy to absorb, have
The health-care efficacy of strengthen immunity is suitble to immunocompromised person to use, and has the function of to adjust body immunity, inhibits tumour, prolongs
The health-care effects such as slow aging.
A kind of embodiment 8, preparation method of Reishi sporule medicinal granules of powder provided by the invention, specifically includes following steps：
(1) ganoderma spove powder is prepared as raw material, it is spare；Further, the specific of ganoderma spove powder is prepared
Method is：
1. degrading Reishi sporule under conditions of temperature is 20~50 DEG C using lywallzyme, degradation solution is obtained；Lywallzyme is adopted
With the mixture of one or more of lysozyme, glusulase, cellulase, hemicellulase；
2. to step 1. in the degradation solution that obtains freezed successively, melt processed, and continuous processing 2~5 times；
3. maintaining the temperature under conditions of 20~50 DEG C, to being carried out at ultrasonication through step 2. treated degradation solution
Reason, broken degradation solution obtain ganoderma spove powder after processing is dried in 60 DEG C of drying box；
(2) cyclodextrin and maltodextrin are weighed respectively, and the cyclodextrin after weighing and maltodextrin are made after evenly mixing
For auxiliary material, the mass ratio of cyclodextrin and maltodextrin is 3:2~7:3；
(3) raw material and auxiliary material are weighed respectively, and raw material is uniformly mixed with auxiliary material, is then sprayed in mixture with wetting agent
And stirring evenly rear spare, the mass ratio of raw material and auxiliary material is 1~3:3~5；Further, the wetting agent which uses is
60%~80% alcohol.
(4) particle is made in the mixture in step (3), and place is dried under conditions of temperature is 60 DEG C in particle
Then reason is screened the particle after drying process by the sieve that mesh number is 20~100 mesh, finally by the pellet after screening
It is vacuum-packed to obtain finished product.
A kind of embodiment 9, preparation method of Reishi sporule medicinal granules of powder provided by the invention, specifically includes following steps：
(1) ganoderma spove powder is prepared as raw material, it is spare；Further, the specific of ganoderma spove powder is prepared
Method is：
1. degrading Reishi sporule under conditions of temperature is 20~50 DEG C using lywallzyme, degradation solution is obtained；Lywallzyme is adopted
With the mixture of one or more of lysozyme, glusulase, cellulase or hemicellulase；
2. to step 1. in the degradation solution that obtains freezed successively, melt processed, and continuous processing 2~5 times；
3. maintaining the temperature under conditions of 20~50 DEG C, to being carried out at ultrasonication through step 2. treated degradation solution
Reason, broken degradation solution obtain ganoderma spove powder after processing is dried in 60 DEG C of drying box；
(2) cyclodextrin and maltodextrin are weighed respectively, and the cyclodextrin after weighing and maltodextrin are made after evenly mixing
For auxiliary material, the mass ratio of cyclodextrin and maltodextrin is 3:2~7:3；
(3) when the electuary further includes hawthorn, coloured malt, hawthorn, coloured malt, raw material and auxiliary material are weighed respectively, by hawthorn,
Coloured malt obtains solid powder after carrying out co-grinding processing, and solid powder is uniformly mixed with raw material, auxiliary material, then with wet
Profit agent is sprayed in mixture, stirs evenly rear spare, and the mass ratio of raw material and auxiliary material is 1~3:3~5, hawthorn, coloured malt exist
Mass percent in electuary is 1%~3%；Further, the specific method of co-grinding processing is carried out to hawthorn, coloured malt
For：First, it is uniformly mixed after hawthorn, coloured malt being cleaned, the water of 3 times of solid amount is added, boils 3 times, then, passes through 100
After purpose screen filtration, filtrate is evaporated, the solids of acquisition, finally, hawthorn and coloured malt is obtained after solids is crushed
Solid powder.
(4) particle is made in the mixture in step (3), and place is dried under conditions of temperature is 60 DEG C in particle
Then reason is screened the particle after drying process by the sieve that mesh number is 20~100 mesh, finally by the pellet after screening
It is vacuum-packed to obtain finished product.
Experiment two：By following experiment, verification ganoderma lucidium spore powder wall breaking is different from not broken wall treatment mode, to granule granule
The influence of interior active constituent.
By above-mentioned preparation method, using ganoderma spove powder and not, ganoderma spove powder is made as raw material respectively
Granule granule is detected analysis, testing number to ganoderma lucidum albumen, ganoderma lucidum polysaccharide, ganodenic acid isoreactivity ingredient in particle respectively
According to shown in such as following table (table two)：
| Conidia powder processing mode | Ganoderma lucidum albumen (mg/ml) | Ganoderma lucidum polysaccharide (mg/ml) | Ganodenic acid (mg/ml) |
| Not broken wall | 0.025bB | 0.31bB | 0.32bB |
| Broken wall | 0.079aA | 0.39aA | 0.38aA |
By tables of data it is found that in ganoderma spove powder containing ganoderma lucidum albumen, ganoderma lucidum polysaccharide, three kinds of activity of ganodenic acid at
The content divided is above not ganoderma spove powder, and there are pole significant differences, mainly due to the cell wall of Reishi sporule richness
Containing cellulose, chitin etc., it is complicated, and acid and alkali-resistance, the release of active material is hindered, breaking trachytectum of glossy ganoderma processing is advantageous
The dissolution of the active ingredients such as ganodenic acid, ganoderma lucidum polysaccharide and ganoderma lucidum albumen, increases human body to above-mentioned object in lucidum spore powder
The possibility that matter is absorbed and utilized.
In addition, the specific wall-breaking method of lucidum spore powder provided by the invention, wall-breaking method is simple, easy to operation, existing
Mechanical Crushing in technology has the following defects：Food and the surface area contacted increase of canister and the raising of temperature can all increase
Substance in rustless steel container is added to dissolve out, if the conidia powder after broken wall is exposed under aerobic environment, on the one hand it contains not
Autoxidation can occur for saturated fatty acid, generate the complex mixture that peroxide is then degraded into volatile aldehyde, ketone and acid, separately
Grease can be decomposed into free fatty and glycerine by the microorganism in one side air, these aliphatic acid are through serial enzymatic reaction meeting
Volatile lower ketones are generated, glycerine can then be oxidized to 1, the 2- epoxy propionic aldehyde with foreign odor, these harmful substances can be destroyed
Other active ingredients in conidia powder seriously affect the quality of conidia powder and then generate harm, the wall-breaking method to the health of people
It is easy to operate, it is easy to operation.
Experiment three：By following experiment, verify in Reishi sporule medicinal granules of powder preparation method, different alcohol concentrations are to electuary
The influence of granular mass.
According to the preparation method for the Reishi sporule medicinal granules of powder that embodiment 8 and 9 provides, selection successively uses the wine of various concentration
Essence prepares granule granule, and carries out quality testing to granule granule respectively, and quality testing includes following several (tables three)：
It is learnt by above-mentioned tables of data, 1. with the increase of alcohol concentration, ratio of briquetting works as wine in downward trend after first increasing
Ratio of briquetting reaches maximum value 95% when essence a concentration of 60%, and grain forming rate standard is defined as ＞ 85%, and therefore, alcohol concentration is
Ratio of briquetting reaches standard when 60%~80%.2. the increase of alcohol concentration, heap density is in be gradually reduced the trend of rising, highly concentrated
The alcohol of degree makes particle viscosity increase, minimum value 443.5kg/m3, maximum value 501.3kg/m3, and heap density (mark up to standard
Standard is defined as 200~600kg/m3).3. the increase of alcohol concentration, angular stop is in increased trend, and angular stop minimum value is
0.42, maximum value 0.49, therefore, angular stop reach requirement (α≤0.839 standard th (40 °)).4. with alcohol concentration
Increase, auxiliary material all melts, and conidia powder slight turbid basically reaches the requirement for the rate of dissolving；5. hydroscopicity standard is defined as≤
6%, data show that maximum value is 1.3%, are far below standard value, therefore, hydroscopicity reaches standard.6. Health Regulations bacterium mark
Standard is≤10000/g, and alcohol has a bactericidal effect, and data shows the used number of bacteria that handles well below standard, therefore,
Product number of bacteria meets hygienic requirements.
It can be seen that according to above-mentioned experimental result and data analysis, when alcohol concentration is 60%~80%, viscosity is suitble to
Lucidum spore powder is pelletized, and granulation is more in line with requirement, therefore the alcohol that currently preferred wetting agent is 60%~80%.
Reishi sporule medicinal granules of powder provided by the invention strictly controls each step in preparation method, includes being done to ingredient
Dry, mixing, crushing etc., check on to each stage, overall process strictly monitors, in addition, electuary curative effect key is that every packet electuary
The content of contained ganoderma active substance, only content have reached standard, the drug effect of its application of competence exertion.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, any made by repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (5)
1. a kind of Reishi sporule medicinal granules of powder, which is characterized in that the electuary includes raw material and auxiliary material, and the mass ratio of raw material and auxiliary material is
1~3:3~5, raw material is ganoderma spove powder, and auxiliary material is the mixture of beta-cyclodextrin and maltodextrin；
The preparation method of the electuary is：
(1) ganoderma spove powder is prepared as raw material, it is spare；
(2) beta-cyclodextrin and maltodextrin are weighed respectively, and the beta-cyclodextrin after weighing and maltodextrin are made after evenly mixing
For auxiliary material, the mass ratio of cyclodextrin and maltodextrin is 3:2~7:3；
(3) raw material and auxiliary material are weighed respectively, raw material is uniformly mixed with auxiliary material, are then sprayed to 60%~80% alcohol mixed
It closes in object and stirs evenly rear spare, the mass ratio of raw material and auxiliary material is 1~3:3~5；
(4) particle is made in the mixture in step (3), and processing is dried under conditions of temperature is 60 DEG C in particle,
Then by the particle after drying process by mesh number be 20~100 mesh sieve screen, finally by the pellet after screening into
Row vacuum packaging obtains finished product.
2. a kind of Reishi sporule medicinal granules of powder, which is characterized in that the electuary by ganoderma spove powder, beta-cyclodextrin, maltodextrin,
Hawthorn and coloured malt are made, and the mass ratio of ganoderma spove powder and beta-cyclodextrin, maltodextrin mixture is 1~3:3~5,
Hawthorn, coloured malt, mass percent of two kinds of ingredients in electuary is respectively 1%~3%；
The preparation method of the electuary is：
(1) ganoderma spove powder is prepared, it is spare；
(2) beta-cyclodextrin and maltodextrin are weighed respectively, and the beta-cyclodextrin after weighing and maltodextrin are made after evenly mixing
For auxiliary material, the mass ratio of beta-cyclodextrin and maltodextrin is 3:2~7:3；
(3) hawthorn, coloured malt, the ganoderma spove powder in step (1), the beta-cyclodextrin in step (2) and wheat are weighed respectively
Hawthorn, coloured malt are obtained solid powder by bud cyclodextrin mixtures after carrying out co-grinding processing, and by solid powder and step
(1) beta-cyclodextrin in ganoderma spove powder, step (2) and maltodextrin mixture in uniformly mix, then with 60%
~80% alcohol is sprayed in mixture, is stirred evenly rear spare；
(4) particle is made in the mixture in step (3), and processing is dried under conditions of temperature is 60 DEG C in particle,
Then by the particle after drying process by mesh number be 20~100 mesh sieve screen, finally by the pellet after screening into
Row vacuum packaging obtains finished product.
3. Reishi sporule medicinal granules of powder according to claim 2, which is characterized in that carry out co-grinding to hawthorn, coloured malt
The specific method of processing is：First, it is uniformly mixed after hawthorn, coloured malt being cleaned, the water of 3 times of solid amount is added, boils 3
It is secondary, then, after the screen filtration by 100 mesh, filtrate is evaporated, the solids of acquisition, finally, is obtained after solids is crushed
The solid powder of hawthorn and coloured malt.
4. Reishi sporule medicinal granules of powder according to claim 1 or 2, which is characterized in that in the step (1), prepare broken
The specific method of wall lucidum spore powder is：
1. degrading Reishi sporule under conditions of temperature is 20~50 DEG C using lywallzyme, degradation solution is obtained；
2. to step 1. in the degradation solution that obtains freezed successively, melt processed, and continuous processing 2~5 times；
3. maintaining the temperature under conditions of 20~50 DEG C, to carrying out ultrasonication processing through step 2. treated degradation solution, break
Degradation solution after broken obtains ganoderma spove powder after processing is dried in 60 DEG C of drying box.
5. Reishi sporule medicinal granules of powder according to claim 4, which is characterized in that the step 1. in, lywallzyme be it is molten
The mixture of one or more of bacterium enzyme, glusulase, cellulase, hemicellulase.
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| CN105851387A (en) * | 2016-05-04 | 2016-08-17 | 叶阿彬 | Preparation process of compound lucid ganoderma and red date tea |
| CN106845383B (en) | 2017-01-16 | 2023-06-06 | 腾讯科技（上海）有限公司 | Human head detection method and device |
| CN107149632A (en) * | 2017-05-17 | 2017-09-12 | 武夷山元生泰生物科技有限公司 | It is a kind of that there is the Reishi sporule radix tetrastigme pulvis and preparation method for treating lung cancer effect |
| CN109480271A (en) * | 2017-09-11 | 2019-03-19 | 孙继勇 | A kind of preparation method of ganoderma spove powder dripping pill |
| KR102440441B1 (en) * | 2017-09-28 | 2022-09-06 | (주)아모레퍼시픽 | Method for producing extracts of Ganoderma lucidum, the extracts produced thereby, and the anti-aging cosmetic composition containing the same |
| CN108338358A (en) * | 2018-05-24 | 2018-07-31 | 安徽省霍山县品堂生物科技有限公司 | A kind of preparation method of Reishi sporule amyloid proteins electuary |
| CN108904548A (en) * | 2018-09-14 | 2018-11-30 | 江苏安惠生物科技有限公司 | The method of room temperature extraction edible and medical fungi effective component |
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