CN104257887B - A kind of composition for promoting lead discharging and its application - Google Patents
A kind of composition for promoting lead discharging and its application Download PDFInfo
- Publication number
- CN104257887B CN104257887B CN201410568834.2A CN201410568834A CN104257887B CN 104257887 B CN104257887 B CN 104257887B CN 201410568834 A CN201410568834 A CN 201410568834A CN 104257887 B CN104257887 B CN 104257887B
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- fruit extract
- composition
- lead
- powder
- zinc
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- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention belongs to biological technical field, a kind of composition for promoting lead discharging and its application are disclosed.The composition for the promotion lead discharging that the present invention is provided includes seabuckthorn fruit extract and wolfberry fruit extract.The present invention generates after seabuckthorn fruit extract and wolfberry fruit extract compounding synergy, significantly improves lead discharging effect, can apply to prepare the health products or food for promoting lead discharging.The health products that the composition of the promotion lead discharging provided using the present invention is prepared into, can effectively facilitate body lead discharging.
Description
Technical field
The invention belongs to biological technical field, more particularly to a kind of composition for promoting lead discharging and its application.
Background technology
Lead is a kind of metallic element, can be used as the material of sulfuric acid corrosion resistant, anti-gamma ray, battery etc..However, lead pair
Body nerve, blood, digestion, internal system and internal body viscera organ are toxic, according to investigations in the toxic substance reported
In matter poisoning, lead poisoning event is most.With the rapid development of economy, lead is widely used in industry, traffic, building respectively
Individual field, pollutes increasingly serious；In chronic occupational disease, lead poisoning is first place, it was reported that national occupational lead poisoning illness rate
More than 10%.Lead poisoning endangers very big to body, and Long Term Contact lead and its compound can cause palpitaition, emotional, red blood cell
Increase；Lead is invaded after nervous system, insomnia occurs, dreaminess, hypomnesia, tired, so develop into it is manic, blind, mind mould
Paste, stupor, it is finally dead because of cerebrovascular anoxic；Lead can also carcinogenic, teratogenesis, mutagenesis.More seriously lead loss hinders baby children
Youngster is cognitive and the brain function such as neurobehavioral, influences it to grow and intelligence development.
Lead in vivo depot accumulation time length, excretion be slowly chronic lead poisoning and lead poisoning acute attack one of the main reasons,
Therefore body lead discharging is to prevent and treat one of Main Means of lead poisoning.At present, main lead discharging means are medicine lead discharging, main
The lead discharging medicine wanted includes chemistry clinical lead discharging medicine and natural plants lead discharging material.In chemistry clinical lead discharging medicine, grind at present
Studying carefully more medicine has natrium adetate, sodium dimercaptosuccinate, dimercaptosuccinic acid, penicillamine etc., but western medicine pair is made
With big, while the indispensable trace element of human body can be discharged, so being used just for the patient being seriously poisoned.For blood lead
Level is too high but is not up to the patient being seriously poisoned, and also lacks effective prevention and treatment means.
As the improvement of people's living standards, everybody increasingly focuses on body lead discharging, the mode of many people's selection dietotherapies is come
Promote body lead discharging, the discovery of this and natural plants lead-expelling function has great relation.According to research reports, using natural plants come
Promote body lead discharging that there is certain effect.At present, promote the natural plant product report of body lead discharging less, it is most only to contain
Single active ingredient, DeGrain, so, in addition it is also necessary to the material for promoting lead discharging is studied, preferably to prevent and treat body
Lead poisoning.
The content of the invention
In view of this, goal of the invention of the invention is to provide a kind of composition for promoting lead discharging and its application.The present invention
The composition of the promotion lead discharging of offer generates synergy, significantly by after seabuckthorn fruit extract and wolfberry fruit extract compounding
Lead discharging effect of composition is improved, can be applied to prepare the health products or food for promoting lead discharging.
In order to realize the goal of the invention of the present invention, the present invention is adopted the following technical scheme that：
The invention provides a kind of composition of promotion lead discharging, it includes seabuckthorn fruit extract and wolfberry fruit extract.
In the present invention, seabuckthorn fruit extract refers to fructus hippophae through pressure in the composition for the promotion lead discharging that the present invention is provided
Squeeze, sterilize, settle, the process such as dry is made, and 1000mg/100g is reached with ascorbic content in gained seabuckthorn fruit extract,
The content of general flavone reaches that 0.2% is defined.
In some embodiments of the invention, the seabuckthorn fruit extract in the composition for the promotion lead discharging that the present invention is provided
Preparation method is：Fructus hippophae → squeezing → high-temperature short-time sterilization → sedimentation, filtering → spray drying → sieving → filling → full item
Inspection → outer packing → storage.
The system that the source of seabuckthorn fruit extract in the composition for the promotion lead discharging that the present invention is provided is not provided by the present invention
The limitation of Preparation Method, those skilled in the art can prepare or buy according to actual conditions and obtain.
In the present invention, wolfberry fruit extract refers to that matrimony vine returns by pure water in the composition for the promotion lead discharging that the present invention is provided
Flow extract to be made, the content of polysaccharide reaches that 4% is defined in gained wolfberry fruit extract.
In some embodiments of the invention, in the composition for the promotion lead discharging that the present invention is provided, the system of wolfberry fruit extract
Preparation Method is：Matrimony vine raw material → pure water refluxing extraction → filtering → filtrate → vacuum concentration → drying → crushing → sieving → packaging
Obtain finished product.
The preparation that the source of wolfberry fruit extract in the composition for the promotion lead discharging that the present invention is provided is not provided by the present invention
The limitation of method, those skilled in the art can prepare or buy according to actual conditions and obtain.
In the present invention, the present invention generates after seabuckthorn fruit extract and wolfberry fruit extract compounding synergy, promoted
Body lead discharging is entered.Experimental result is confirmed, after the composition provided using the present invention, compared to control group, is significantly reduced
The content of lead in Mice Body in femur and liver, significant difference (P ＜ 0.05).
Preferably, in the composition that the present invention is provided, the mass ratio of seabuckthorn fruit extract and wolfberry fruit extract is (1:3)~
(2:1)。
In some embodiments of the invention, in the composition that the present invention is provided, seabuckthorn fruit extract and wolfberry fruit extract
Mass ratio be (3:8)~(8:5).In the other embodiment of the present invention, in the composition that the present invention is provided, fructus hippophae
The mass ratio of extract and wolfberry fruit extract is 3:8、1:2、5:8、1:1、8:5 or 2:1.Implement in the other of the present invention
In example, in the composition that the present invention is provided, the mass ratio of seabuckthorn fruit extract and wolfberry fruit extract is 8:5.
In some embodiments of the invention, in the composition that provides of the present invention, in addition to SKGM, vitamin C,
One or both of calcium, iron, zinc, water-soluble dietary fiber thing mixed above.
In the other embodiment of the present invention, in the composition that the present invention is provided, SKGM is provided by konjaku flour.
In the present invention, the konjaku flour in the composition that the present invention is provided refers to that fresh konjak stem tuber is made by processing, with gained evil spirit
The content of SKGM reaches that 70% is defined in taro powder.SKGM is a kind of high score extracted from the stem tuber of konjaku
Son, non-ionic water-soluble polysaccharide, also referred to as Glucomannan, are a kind of are difficult to by the hemicellulose of human consumption.Study table
Bright, SKGM has stronger specific binding capacity with lead, can reduce the absorption of alimentary canal lead and the storage of internal lead is stayed, and then drop
Low blood lead, liver lead, the content of brain lead or bone lead.
In the other embodiment of the present invention, in the composition that the present invention is provided, the preparation method of konjaku flour is：Newly
Fresh Amorphophallus rivieri stem tuber → peeling → cleaning → section → drying → konjaku angle → crushing → grinding → konjaku powder → alcohol-pickled →
Polishing → high pressure separation → secondary alcohol-pickled → colloid mill is levigate → centrifuge drying → vacuum drying → pneumatic conveying drying → sieve
Point → homogeneous → packaging.
Preparation method of the source of konjaku flour in the composition that the present invention is provided not by the offer of the present invention is limited, this
Art personnel can prepare or buy according to actual conditions and obtain.
In the other embodiment of the present invention, in the composition that the present invention is provided, vitamin C is provided by cherry powder.
In the other embodiment of the present invention, cherry powder refers to using acerola concentrate as raw material in the composition that the present invention is provided, main
Through the cherry powder made from technique such as enzymolysis, separation, concentration, dry 17% is reached with ascorbic content in gained cherry powder
It is defined.Vitamin C is rich in cherry powder, vitamin C can be combined generation ascorbic acid lead salt with lead, be discharged from enteron aisle, and then
Realize the effect for promoting lead discharging.
In the other embodiment of the present invention, in the composition that the present invention is provided, the preparation method of cherry powder is：Enzyme
Solution → separation → concentration → dehydration → spray drying → inspection → packaging.The preparation side of cherry powder in the composition that the present invention is provided
Method is not limited by the method that the present invention is provided, and those skilled in the art can prepare or buy according to actual conditions and obtain.
In the other embodiment of the present invention, in the composition that the present invention is provided, calcium is provided by cow's milk calcium powder.
In the other embodiment of the present invention, in the composition that the present invention is provided, iron is provided by ferrous gluconate.
In the other embodiment of the present invention, in the composition that the present invention is provided, zinc is provided by zinc gluconate.
Calcium, iron, Zn-ef ficiency and lead belong to divalent metal element together, have Competition in metabolic process in vivo, in small intestine
Same delivery associated proteins are competed, so the supply of calcium, iron, zinc can suppress the absorption of lead.
In the other embodiment of the present invention, the water-soluble dietary fiber in the composition that the present invention is provided belongs to meals
Eat fiber in one kind, it can not be digested by body, there is powerful capturing ability to lead, can in enteron aisle the heavy metal such as lead, mercury
Insoluble, nonabsorbable huge network structure compound is formed, is excluded in vitro, internal lead is effectively removed, lead poisoning is prevented and treated.
In the present invention, test result indicates that, what the present invention was provided includes the group of seabuckthorn fruit extract and wolfberry fruit extract
Compound can promote body lead discharging.In the other embodiment of the present invention, the present invention is carried seabuckthorn fruit extract, matrimony vine
One or both of thing and SKGM, vitamin C, calcium, iron, zinc, water-soluble dietary fiber thing mixed above is taken to compound it
Afterwards, effect that resulting composition promotes body lead discharging is further increased.In the other embodiment of the present invention, the present invention
The composition of offer can effectively facilitate children's lead discharging.In the other embodiment of the present invention, the combination that the present invention is provided
Thing can improve immunity.
In the other embodiment of the present invention, the composition that the present invention is provided is made up of the component of following parts by weight：
500~1000 parts of seabuckthorn fruit extracts, 500~1000 parts of wolfberry fruit extracts, 50~200 parts of SKGMs, 20~
50 parts of vitamin Cs, 50~200 parts of calcium, 6~20 parts of iron, 10~50 parts of zinc and 500~1500 parts of water-soluble dietary fibers.
The application in promoting the health products or food of lead discharging, said composition are being prepared present invention also offers a kind of composition
Including seabuckthorn fruit extract and wolfberry fruit extract.
The invention provides a kind of food, it includes a kind of composition, and said composition includes seabuckthorn fruit extract and matrimony vine
Extract.
Present invention also offers a kind of health products, it includes the composition of the invention provided and pharmaceutically acceptable auxiliary
Material, said composition includes seabuckthorn fruit extract and wolfberry fruit extract.
In some embodiments of the invention, in the health products that the present invention is provided, pharmaceutically acceptable auxiliary material includes rectifying
One or both of taste agent, filler, coating material, lubricant, disintegrant thing mixed above.
In some embodiments of the invention, in the health products that the present invention is provided, flavouring is isomalt, lemon
One or both of acid, orange flavor or Sucralose thing mixed above.
In the other embodiment of the present invention, in the health products that provide of the present invention, filler is starch, dextrin, micro-
One or both of crystalline cellulose thing mixed above.
In the other embodiment of the present invention, in the health products that the present invention is provided, coating material is film coating powder.
In the other embodiment of the present invention, in the health products that the present invention is provided, lubricant is silica, tristearin
One or both of sour magnesium, talcum powder thing mixed above.
In the other embodiment of the present invention, in the health products that the present invention is provided, disintegrant is PVPP, carboxylic
Methyl starch sodium, one or both of low substituted hydroxy-propyl methylcellulose thing mixed above.
Preferably, the formulation for the health products that the present invention is provided is chewable tablets, coating tablet or capsule.
In some embodiments of the invention, in the health products that the present invention is provided, when the formulation of the health products is chewable tablets
When, including following components：Promote composition, SKGM, vitamin C, calcium, iron, zinc, lubricant, the flavouring of lead discharging.
In the other embodiment of the present invention, in the health products that the present invention is provided, when the health products are chewable tablets,
Each component including following parts by weight：
500~1000 parts of seabuckthorn fruit extracts, 500~1000 parts of wolfberry fruit extracts, 50~200 parts of SKGMs, 20~
50 parts of vitamin Cs, 50~200 parts of calcium, 6~20 parts of iron, 10~50 parts of zinc, 1~4 part of lubricant, 100~250 parts of flavourings.
In the other embodiment of the present invention, in the health products that the present invention is provided, when the formulation of the health products is nozzle
When chewing piece, in addition to water-soluble dietary fiber.
In the other embodiment of the present invention, in the health products that the present invention is provided, the formulation of the health products is coating
During piece, including following components：Promote composition, SKGM, vitamin C, calcium, iron, zinc, disintegrant, the lubricant of lead discharging, fill out
Fill agent.
In the other embodiment of the present invention, in the health products that the present invention is provided, when the health products are coating tablet,
Each component including following parts by weight：
500~1000 parts of seabuckthorn fruit extracts, 500~1000 parts of wolfberry fruit extracts, 50~100 parts of SKGMs, 50~
100 parts of vitamin Cs, 200~500 parts of calcium, 20~50 parts of iron, 10~50 parts of zinc, 100~500 parts of disintegrants, 1~4 part of lubrication
Agent, 500~1500 parts of fillers.
In the other embodiment of the present invention, in the health products that the present invention is provided, when the formulation of the health products is bag
During garment piece, in addition to water-soluble dietary fiber.
In the other embodiment of the present invention, in the health products that the present invention is provided, the formulation of the health products is capsule
During agent, including following components：Promote composition, SKGM, vitamin C, calcium, iron, zinc, filler, the lubricant of lead discharging.
In the other embodiment of the present invention, in the health products that the present invention is provided, when the formulation of the health products is glue
During wafer, include each component of following parts by weight：
500~1000 parts of seabuckthorn fruit extracts, 500~1000 parts of wolfberry fruit extracts, 50~100 parts of SKGMs, 50~
100 parts of vitamin Cs, 200~500 parts of calcium, 20~50 parts of iron, 10~50 parts of zinc, 100~500 parts of disintegrants, 1~4 part of lubrication
Agent, 500~1500 parts of fillers.
In the other embodiment of the present invention, in the health products that the present invention is provided, when the formulation of the health products is glue
During wafer, in addition to water-soluble dietary fiber.
The invention provides a kind of composition for promoting lead discharging and its application.The composition of the promotion lead discharging includes fructus hippophae
Extract and wolfberry fruit extract.The present invention generates after seabuckthorn fruit extract and wolfberry fruit extract compounding synergy, shown
Work improves lead discharging effect, can apply to prepare the health products or food for promoting lead discharging.Experimental result is confirmed, is using this hair
After the composition of bright offer, compared to control group, the content of the lead in Mice Body in femur and liver is significantly reduced, difference shows
Write (P ＜ 0.05).In the other embodiment of the present invention, by seabuckthorn fruit extract, wolfberry fruit extract and SKGM, dimension
After one or both of raw element C, calcium, iron, zinc, water-soluble dietary fiber thing compounding mixed above, institute is further increased
Obtain effect that health products promote body lead discharging.In the other embodiment of the present invention, the composition that the present invention is provided can
Effectively facilitate children's lead discharging.In the other embodiment of the present invention, the composition that the present invention is provided can improve immunity.
Embodiment
The invention discloses a kind of composition for promoting lead discharging and its application.Those skilled in the art may be referred in herein
Hold, obtain the promotion lead discharging composition, realize that it is applied, it is accordingly required in particular to, it is noted that all similar replacements and change are to this
It is it will be apparent that they are considered as being included in the present invention for art personnel.The method of the present invention and application are
Through being described by preferred embodiment, related personnel substantially can not depart from present invention, in spirit and scope it is right
This paper preparation method and application are modified or suitably change is with combining, to realize and apply the technology of the present invention.
Used reagent and raw material Jun Keyou cities in a kind of composition for promotion lead discharging that the present invention is provided and its application
Field is bought.
In order that those skilled in the art better understood when technical scheme, with reference to implementation
Example, is expanded on further the present invention：
The seabuckthorn fruit extract of embodiment 1 and wolfberry fruit extract promote the efficacy study of body lead discharging
Experiment material
Animal：18~22g Kunming the kind bred from Test Animal Centre, Academy of Military Medical Sciences, P.L.A,
Healthy male mice 80, is randomly divided into 8 groups, every group 10.
Instrument：Atomic absorption spectrophotometer.
Acetic acid lead solution：Configure as desired, wherein Pb (Ac)2·3H2O concentration is that 1.0g/L, the concentration of acetic acid are
12.5 μ L/L, the addition of acetic acid can prevent lead salt, the cohesion of lead hydroxide.
Seabuckthorn fruit extract (pulvis), i.e. sea buckthorn juice powder, from fructus hippophae is referred to through squeezing, sterilizing is settled, dried
Etc. process.
Wolfberry fruit extract (pulvis), passes through pure water refluxing extraction from matrimony vine is referred to.
The preparation method of the composition of seabuckthorn fruit extract and wolfberry fruit extract is：Weigh, always mix.
Experimental method
The foundation of lead poisoning model and experiment packet：
Healthy Male Kunming strain mice 80, is randomly divided into 8 groups, is respectively labeled as Normal group, model control group, sun
Property control group, the first control group, the second control group, the first test group, the second test group, the 3rd test group, every group 10.Model
Control group and each dosage group of given the test agent drink lead acetate solution, make to stop modeling to lead after a certain amount of lead of accumulation in animal body,
Give model control group deionized water or basal feed again, each dosage group gavage give given the test agent or feeding containing various dose by
The feed of test agent.
Dosage regimen：
The mouse of each group is taken, is administered daily according to the corresponding relation of each group and testing sample as shown in table 1,
Administering mode is gavage.Wherein, the first control group, the second control group, the first test group, the second test group, the 3rd test group
Dosage is identical, is that 24h fasting for solids and liquids puts to death animal and takes liver and stock after each 13.33g/kg.bw, successive administration 30d
Bone.
The mouse of each group of table 1 and the corresponding relation of testing sample
Testing index：
The assay of femur lead and liver lead:Femur or liver are taken, sampling Graphite Furnace Atomic Absorption spectrophotometric determination is used
The content of lead in femur and liver.
Experimental result
Upon administration, each mouse is in good condition in experimentation, no abnormal for the mouse of different groups.Mouse
The content detection of lead the results are shown in Table 2 in femur and liver, and variance analysis is carried out to acquired results, and analysis result is shown in Table 2.
The mouse of the different group of table 2 upon administration in femur and liver lead content (X ± S) (mg/kg)
Note：Compared with Normal group, * represents P<0.05, * * represents P<0.01；Contrasted with model group,▲Represent P<
0.05,▲▲Represent P<0.01.
It can be seen from experimental result, compared to normal control, model control group femur lead content, liver lead content have significantly
Sex differernce (P ＜ 0.01), illustrates the success of mice with lead poisoning model construction；Contrast positive controls mouse and model control group mouse
Femur lead content, liver lead content understand, both significant differences, with statistical significance (P ＜ 0.01)；Compared to model comparison
Group, the first control group, the mouse femur lead content of the second control group, liver lead content are all significantly reduced, significant difference (P ＜
0.05)；Illustrate mice with lead poisoning after positive control medicine, seabuckthorn fruit extract, wolfberry fruit extract is received, femur and liver
In lead content decrease, promote body lead discharging.
It was found from experimental result, compared to model control group, in the first experimental group, the second experimental group, the lead of the 3rd experimental group
The femur lead and liver lead content of malicious model mice have an obvious reduction, difference and its significantly (P ＜ 0.01), illustrate sea-buckthorn
After berry extract and wolfberry fruit extract are compounded, still with significant lead-eliminating effect.Compared to the first control group, second pair
Understand that under the conditions of identical dosage, the lead discharging effect of the composition of seabuckthorn fruit extract and wolfberry fruit extract is obtained according to group
To significantly improving, lead content difference is statistically significant (P ＜ 0.01) in femur；Lead content significant difference in liver, (P ＜
0.01), illustrate after being compounded seabuckthorn fruit extract and wolfberry fruit extract, generate synergy, significantly improve group
Compound promotes effect of lead discharging, and resulting composition can be applied to prepare the health products or food for promoting lead discharging.
Embodiment 2 promotes the preparation of the composition of lead discharging
Experiment material
Seabuckthorn fruit extract (pulvis), i.e. sea buckthorn juice powder, from fructus hippophae is referred to through squeezing, sterilizing is settled, dried
Etc. process.
Wolfberry fruit extract (pulvis), passes through pure water refluxing extraction from matrimony vine is referred to.
Formula
Seabuckthorn fruit extract 500g；Wolfberry fruit extract 1500g；
Preparation method
The preparation method of the composition of seabuckthorn fruit extract and wolfberry fruit extract is：Weigh respectively, always mix 30min.
Embodiment 3 promotes the preparation of the composition of lead discharging
Experiment material
Seabuckthorn fruit extract (pulvis), i.e. sea buckthorn juice powder, from fructus hippophae is referred to through squeezing, sterilizing is settled, dried
Etc. process.
Wolfberry fruit extract (pulvis), passes through pure water refluxing extraction from matrimony vine is referred to.
Formula
Seabuckthorn fruit extract 1000g；Wolfberry fruit extract 500g；
Preparation method
The preparation method of the composition of seabuckthorn fruit extract and wolfberry fruit extract is：Various materials are weighed respectively, always mixed
30min。
Embodiment 4 promotes the preparation of the composition of lead discharging
Experiment material
Seabuckthorn fruit extract (pulvis), i.e. sea buckthorn juice powder, from fructus hippophae is referred to through squeezing, sterilizing is settled, dried
Etc. process.
Wolfberry fruit extract (pulvis), passes through pure water refluxing extraction from matrimony vine is referred to.
Konjaku flour refers to that fresh konjak stem tuber is made by processing, is reached with the content of SKGM in gained konjaku flour
70% is defined.
Cherry powder refers to using acerola concentrate as raw material, mainly through the cherry made from technique such as enzymolysis, separation, concentration, dry
Powder, ascorbic content reaches that 17% is defined in gained cherry powder.
Cow's milk calcium powder is derived from：Whey is raw material, through going the compositions such as isolating protein, lactose to process.Wherein calcium contains
Measure as 24.0-28.0%.
Ferrous gluconate is derived from：Chemical synthesis is made, and wherein the content of iron is 12.5%.
Zinc gluconate is derived from：Calcium gluconae is initiation material, acidified to be reacted with zinc compound or with grape
Saccharic acid lactone is raw material and the obtained zinc gluconate of Zinc compounds reaction.Wherein the content of zinc is 14.26%.
Water-soluble fibre is derived from：Cornstarch decolourizes by purifying, dries, screening, and the process such as packaging is made.
Formula
Seabuckthorn fruit extract 1000g, wolfberry fruit extract 500g, 71.5g konjaku flour (equivalent to 50g SKGMs), 580g
Cherry powder (equivalent to 100g vitamin Cs), 800g cow's milk calcium powder (equivalent to 200g calcium), 400g ferrous gluconates (equivalent to
50g iron), 70g zinc gluconates (equivalent to 10g zinc), 1000g water-soluble dietary fibers.
Preparation method:First ferrous gluconate and zinc gluconate are weighed according to formula ratio, 25min, Ran Houzai is mixed
Seabuckthorn fruit extract, wolfberry fruit extract, konjaku flour, cherry powder, the cow's milk calcium powder of input formula ratio, water-soluble dietary fiber, together
When add a certain amount of isomalt and anhydrous citric acid, orange flavor, the flavouring such as Sucralose is mixed, and is mixed
Time 30min.
Embodiment 5 promotes the preparation of the composition of lead discharging
Experiment material
Seabuckthorn fruit extract (pulvis), i.e. sea buckthorn juice powder, from fructus hippophae is referred to through squeezing, sterilizing is settled, dried
Etc. process.
Wolfberry fruit extract (pulvis), passes through pure water refluxing extraction from matrimony vine is referred to.
Konjaku flour refers to that fresh konjak stem tuber is made by processing, is reached with the content of SKGM in gained konjaku flour
70% is defined.
Cherry powder refers to using acerola concentrate as raw material, mainly through the cherry made from technique such as enzymolysis, separation, concentration, dry
Powder, ascorbic content reaches that 17% is defined in gained cherry powder.
Cow's milk calcium powder is derived from：Whey is raw material, through going the compositions such as isolating protein, lactose to process.Wherein calcium contains
Measure as 24.0-28.0%.
Ferrous gluconate is derived from：Chemical synthesis is made, and wherein the content of iron is 12.5%.
Zinc gluconate is derived from：Calcium gluconae is initiation material, acidified to be reacted with zinc compound or with grape
Saccharic acid lactone is raw material and the obtained zinc gluconate of Zinc compounds reaction.Wherein the content of zinc is 14.26%.
Water-soluble fibre is derived from：Cornstarch decolourizes by purifying, dries, screening, and the process such as packaging is made.
Formula
Seabuckthorn fruit extract 800g, wolfberry fruit extract 800g, 143g konjaku flour (equivalent to 100g SKGMs), 294g cherries
Peach powder (equivalent to 50g vitamin Cs), 2000g cow's milk calcium powder (equivalent to 500g calcium), 160g ferrous gluconates are (equivalent to 20g
Iron), 350g zinc gluconates (equivalent to 50g zinc), 500g water-soluble dietary fibers.
Preparation method：Put into formula ratio ferrous gluconate, zinc gluconate, seabuckthorn fruit extract, wolfberry fruit extract,
Konjaku flour, cherry powder, cow's milk calcium powder, water-soluble dietary fiber, while adding a certain amount of isomalt and anhydrous lemon
Acid, orange flavor, the flavouring such as Sucralose is mixed, incorporation time 30min.
Embodiment 6 promotes the preparation of the chewable tablets of lead discharging
Experiment material
Seabuckthorn fruit extract (pulvis), i.e. sea buckthorn juice powder, from fructus hippophae is referred to through squeezing, sterilizing is settled, dried
Etc. process.
Wolfberry fruit extract (pulvis), passes through pure water refluxing extraction from matrimony vine is referred to.
Konjaku flour refers to that fresh konjak stem tuber is made by processing, is reached with the content of SKGM in gained konjaku flour
70% is defined.
Cherry powder refers to using acerola concentrate as raw material, mainly through the cherry made from technique such as enzymolysis, separation, concentration, dry
Powder, ascorbic content reaches that 17% is defined in gained cherry powder.
Cow's milk calcium powder is derived from：Whey is raw material, through going the compositions such as isolating protein, lactose to process.Wherein calcium contains
Measure as 24.0-28.0%.
Ferrous gluconate is derived from：Chemical synthesis is made, and wherein the content of iron is 12.5%.
Zinc gluconate is derived from：Calcium gluconae is initiation material, acidified to be reacted with zinc compound or with grape
Saccharic acid lactone is raw material and the obtained zinc gluconate of Zinc compounds reaction.Wherein the content of zinc is 14.26%.
Formula
Seabuckthorn fruit extract 267g；Wolfberry fruit extract 167g；25g konjaku flours (equivalent to 17.5g SKGMs), 30g cherries
Peach powder (equivalent to 5.1g vitamin Cs), 133g cow's milk calcium powder (equivalent to 33.3g calcium), 9.3g ferrous gluconates (equivalent to
1.16g iron), 7g zinc gluconates (equivalent to 1g zinc), 247.7g isomalts, 220g microcrystalline celluloses, 35g crosslinkings it is poly-
Tie up ketone, 25g anhydrous citric acids, 10g orange flavors, 10g silica, 10g magnesium stearates, 4g Sucraloses.
Preparation method
Each component is weighed according to formula, it is standby；Seabuckthorn fruit extract, wolfberry fruit extract, cow's milk calcium powder, cherry are taken respectively
Powder sieving for standby；By konjaku flour, ferrous gluconate, zinc gluconate, isomalt, microcrystalline cellulose, the poly- dimension of crosslinking
Ketone, anhydrous citric acid, orange flavor, silica after Sucralose is well mixed, adds magnesium stearate and continues to mix, mixing
Uniformly.Tabletting machine, piece weight is 1.2g/ pieces,
It is prepared into 1000.
Embodiment 7 promotes the preparation of the chewable tablets of lead discharging
Experiment material
Seabuckthorn fruit extract (pulvis), i.e. sea buckthorn juice powder, from fructus hippophae is referred to through squeezing, sterilizing is settled, dried
Etc. process.
Wolfberry fruit extract (pulvis), passes through pure water refluxing extraction from matrimony vine is referred to.
Konjaku flour refers to that fresh konjak stem tuber is made by processing, is reached with the content of SKGM in gained konjaku flour
70% is defined.
Cherry powder refers to using acerola concentrate as raw material, mainly through the cherry made from technique such as enzymolysis, separation, concentration, dry
Powder, ascorbic content reaches that 17% is defined in gained cherry powder.
Cow's milk calcium powder is derived from：Whey is raw material, through going the compositions such as isolating protein, lactose to process.Wherein calcium contains
Measure as 24.0-28.0%.
Ferrous gluconate is derived from：Chemical synthesis is made, and wherein the content of iron is 12.5%.
Zinc gluconate is derived from：Calcium gluconae is initiation material, acidified to be reacted with zinc compound or with grape
Saccharic acid lactone is raw material and the obtained zinc gluconate of Zinc compounds reaction.Wherein the content of zinc is 14.26%.
Water-soluble dietary fiber is derived from：Cornstarch decolourizes by purifying, dries, screening, and the process such as packaging is made.
Formula
Seabuckthorn fruit extract 500g；Wolfberry fruit extract 1000g；71.4g konjaku flours (equivalent to 50g SKGMs), 588g
Cherry powder (equivalent to 100g vitamin Cs), 800g cow's milk calcium powder (equivalent to 200g calcium), 400g ferrous gluconates (equivalent to
50g iron), 70g zinc gluconates (equivalent to 10g zinc), 1000g water-soluble dietary fibers, 140g isomalts, 258.6g
Microcrystalline cellulose, 54g PVPPs, 50g anhydrous citric acids, 20g orange flavors, 24g silica, 24g magnesium stearates, g
Sucralose.
Preparation method
Each component is weighed according to formula, it is standby；Seabuckthorn fruit extract, wolfberry fruit extract, cow's milk calcium powder, cherry are taken respectively
Powder sieving for standby；By konjaku flour, ferrous gluconate, zinc gluconate, water-soluble dietary fiber, isomalt, crystallite
Cellulose, PVPP, anhydrous citric acid, orange flavor, silica after Sucralose is well mixed, adds stearic acid
Magnesium continues to mix, and is well mixed.Tabletting machine, piece weight is 4g/ pieces, is produced.
Embodiment 8 promotes the preparation of the chewable tablets of lead discharging
Experiment material
Seabuckthorn fruit extract (pulvis), i.e. sea buckthorn juice powder, from fructus hippophae is referred to through squeezing, sterilizing is settled, dried
Etc. process.
Wolfberry fruit extract (pulvis), passes through pure water refluxing extraction from matrimony vine is referred to.
Konjaku flour refers to that fresh konjak stem tuber is made by processing, is reached with the content of SKGM in gained konjaku flour
70% is defined.
Cherry powder refers to using acerola concentrate as raw material, mainly through the cherry made from technique such as enzymolysis, separation, concentration, dry
Powder, ascorbic content reaches that 17% is defined in gained cherry powder.
Cow's milk calcium powder is derived from：Whey is raw material, through going the compositions such as isolating protein, lactose to process.Wherein calcium contains
Measure as 24.0-28.0%.
Ferrous gluconate is derived from：Chemical synthesis is made, and wherein the content of iron is 12.5%.
Zinc gluconate is derived from：Calcium gluconae is initiation material, acidified to be reacted with zinc compound or with grape
Saccharic acid lactone is raw material and the obtained zinc gluconate of Zinc compounds reaction.Wherein the content of zinc is 14.26%.
Water-soluble dietary fiber is derived from：Cornstarch decolourizes by purifying, dries, screening, and the process such as packaging is made.
Formula
Seabuckthorn fruit extract 1000g；Wolfberry fruit extract 500g, 143g konjaku flour (equivalent to 100g SKGMs), 294g
Cherry powder (equivalent to 50g vitamin Cs), 2000g cow's milk calcium powder (equivalent to 500g calcium), 160g ferrous gluconates (equivalent to
20g iron), 350g zinc gluconates (equivalent to 50g zinc), 500g water-soluble dietary fibers, 100g isomalts, 150g it is micro-
Crystalline cellulose, 123g PVPPs, 80g anhydrous citric acids, 40g orange flavors, 30g silica, 30g magnesium stearates, g tri-
Chlorine sucrose.
Preparation method
Each component is weighed according to formula, it is standby；Seabuckthorn fruit extract, wolfberry fruit extract, cow's milk calcium powder, cherry are taken respectively
Powder sieving for standby；By konjaku flour, ferrous gluconate, zinc gluconate, water-soluble dietary fiber, isomalt, crystallite
Cellulose, PVPP, anhydrous citric acid, orange flavor, silica after Sucralose is well mixed, adds stearic acid
Magnesium continues to mix, and is well mixed.Tabletting machine, piece weight is 5.5g/ pieces, is produced.
Embodiment 9 promotes the preparation of the normal packet garment piece of lead discharging
Experiment material
Seabuckthorn fruit extract (pulvis), i.e. sea buckthorn juice powder, from fructus hippophae is referred to through squeezing, sterilizing is settled, dried
Etc. process.
Wolfberry fruit extract (pulvis), passes through pure water refluxing extraction from matrimony vine is referred to.
Konjaku flour refers to that fresh konjak stem tuber is made by processing, is reached with the content of SKGM in gained konjaku flour
70% is defined.
Cherry powder refers to using acerola concentrate as raw material, mainly through the cherry made from technique such as enzymolysis, separation, concentration, dry
Powder, ascorbic content reaches that 17% is defined in gained cherry powder.
Cow's milk calcium powder is derived from：Whey is raw material, through going the compositions such as isolating protein, lactose to process.Wherein calcium contains
Measure as 24.0-28.0%.
Ferrous gluconate is derived from：Chemical synthesis is made, and wherein the content of iron is 12.5%.
Zinc gluconate is derived from：Calcium gluconae is initiation material, acidified to be reacted with zinc compound or with grape
Saccharic acid lactone is raw material and the obtained zinc gluconate of Zinc compounds reaction.Wherein the content of zinc is 14.26%.
Film coating powder is derived from：Tianjin Aileyi Medicine Materials Co., Ltd..
Formula
Seabuckthorn fruit extract 267g；Wolfberry fruit extract 167g；25g konjaku flours (equivalent to 17.5g SKGMs), 30g cherries
Peach powder (equivalent to 5.1g vitamin Cs), 133g cow's milk calcium powder (equivalent to 33.3g calcium), 9.3g ferrous gluconates (equivalent to
1.16g iron), 7g zinc gluconates (equivalent to 1.0g zinc), 247.7g isomalts, 225g microcrystalline celluloses, 35g crosslinking
PVP, 10g silica, 10g magnesium stearates, 24g film coating powders.
Preparation method
Each component is weighed according to formula, it is standby；Seabuckthorn fruit extract, wolfberry fruit extract, cow's milk calcium powder, cherry are taken respectively
Powder sieving for standby；By konjaku flour, ferrous gluconate, zinc gluconate, isomalt, microcrystalline cellulose, the poly- dimension of crosslinking
Ketone, after silica is well mixed, adds magnesium stearate and continues to mix, be well mixed.Tabletting machine, piece weight is 1176mg/
Piece, takes film coating powder to be coated, gained coating tablet 1.2g/ pieces.
Embodiment 10 promotes the preparation of the normal packet garment piece of lead discharging
Experiment material
Seabuckthorn fruit extract (pulvis), i.e. sea buckthorn juice powder, from fructus hippophae is referred to through squeezing, sterilizing is settled, dried
Etc. process.
Wolfberry fruit extract (pulvis), passes through pure water refluxing extraction from matrimony vine is referred to.
Konjaku flour refers to that fresh konjak stem tuber is made by processing, is reached with the content of SKGM in gained konjaku flour
70% is defined.
Cherry powder refers to using acerola concentrate as raw material, mainly through the cherry made from technique such as enzymolysis, separation, concentration, dry
Powder, ascorbic content reaches that 17% is defined in gained cherry powder.
Cow's milk calcium powder is derived from：Whey is raw material, through going the compositions such as isolating protein, lactose to process.Wherein calcium contains
Measure as 24.0-28.0%.
Ferrous gluconate is derived from：Chemical synthesis is made, and wherein the content of iron is 12.5%.
Zinc gluconate is derived from：Calcium gluconae is initiation material, acidified to be reacted with zinc compound or with grape
Saccharic acid lactone is raw material and the obtained zinc gluconate of Zinc compounds reaction.Wherein the content of zinc is 14.26%.
Water-soluble dietary fiber is derived from：Cornstarch decolourizes by purifying, dries, screening, and the process such as packaging is made.
Film coating powder is derived from：Tianjin Aileyi Medicine Materials Co., Ltd..
Formula
Seabuckthorn fruit extract 300g；Wolfberry fruit extract 800g；71.4g konjaku flours (equivalent to 50g SKGMs), 588g cherries
Peach powder (equivalent to 100g vitamin Cs), 2000g cow's milk calcium powder (equivalent to 500g calcium), 400g ferrous gluconates (equivalent to
50g iron), 70g zinc gluconates (equivalent to 10g zinc), 1000g water-soluble dietary fibers, 314.6g isomalts, 240g
Microcrystalline cellulose, 54g PVPPs, 54g silica, 54g magnesium stearates, 54g film coating powders.
Preparation method
Each component is weighed according to formula, it is standby；Seabuckthorn fruit extract, wolfberry fruit extract, cow's milk calcium powder, cherry are taken respectively
Powder sieving for standby；By konjaku flour, ferrous gluconate, zinc gluconate, isomalt, microcrystalline cellulose, the poly- dimension of crosslinking
Ketone, after silica is well mixed, adds magnesium stearate and continues to mix, be well mixed.Tabletting machine, piece weight is
1336.5mg/ pieces, take film coating powder to be coated, gained coating tablet 1350g/ pieces
Formula is prepared into 4000.
Embodiment 11 promotes the preparation of the normal packet garment piece of lead discharging
Experiment material
Seabuckthorn fruit extract (pulvis), i.e. sea buckthorn juice powder, from fructus hippophae is referred to through squeezing, sterilizing is settled, dried
Etc. process.
Wolfberry fruit extract (pulvis), passes through pure water refluxing extraction from matrimony vine is referred to.
Konjaku flour refers to that fresh konjak stem tuber is made by processing, is reached with the content of SKGM in gained konjaku flour
70% is defined.
Cherry powder refers to using acerola concentrate as raw material, mainly through the cherry made from technique such as enzymolysis, separation, concentration, dry
Powder, ascorbic content reaches that 17% is defined in gained cherry powder.
Cow's milk calcium powder is derived from：Whey is raw material, through going the compositions such as isolating protein, lactose to process.Wherein calcium contains
Measure as 24.0-28.0%.
Ferrous gluconate is derived from：Chemical synthesis is made, and wherein the content of iron is 12.5%.
Zinc gluconate is derived from：Calcium gluconae is initiation material, acidified to be reacted with zinc compound or with grape
Saccharic acid lactone is raw material and the obtained zinc gluconate of Zinc compounds reaction.Wherein the content of zinc is 14.26%.
Film coating powder is derived from：Tianjin Aileyi Medicine Materials Co., Ltd..
Formula
Seabuckthorn fruit extract 1000g；Wolfberry fruit extract 500g；142.8g konjaku flours (equivalent to 100g SKGMs),
294g cherry powders (equivalent to 50g vitamin Cs), 800g cow's milk calcium powder (equivalent to 200g calcium), 160g ferrous gluconates are (quite
In 20g iron), 350g zinc gluconates (equivalent to 50g zinc), 500g water-soluble dietary fibers, 450.2g isomalts,
362g microcrystalline celluloses, 55g PVPPs, 45g silica, 45g magnesium stearates, 96g film coating powders.
Preparation method
Each component is weighed according to formula, it is standby；Seabuckthorn fruit extract, wolfberry fruit extract, cow's milk calcium powder, cherry are taken respectively
Powder sieving for standby；By konjaku flour, ferrous gluconate, zinc gluconate, isomalt, microcrystalline cellulose, the poly- dimension of crosslinking
Ketone, after silica is well mixed, adds magnesium stearate and continues to mix, be well mixed.Tabletting machine, piece weight is 1175mg/
Piece, takes film coating powder to be coated, gained coating tablet 1200g/ pieces.
Formula is prepared into 4000
Embodiment 12 promotes the preparation of the capsule of lead discharging
Experiment material
Seabuckthorn fruit extract (pulvis), i.e. sea buckthorn juice powder, from fructus hippophae is referred to through squeezing, sterilizing is settled, dried
Etc. process.
Wolfberry fruit extract (pulvis), passes through pure water refluxing extraction from matrimony vine is referred to.
Konjaku flour refers to that fresh konjak stem tuber is made by processing, is reached with the content of SKGM in gained konjaku flour
70% is defined.
Cherry powder refers to using acerola concentrate as raw material, mainly through the cherry made from technique such as enzymolysis, separation, concentration, dry
Powder, ascorbic content reaches that 17% is defined in gained cherry powder.
Cow's milk calcium powder is derived from：Whey is raw material, through going the compositions such as isolating protein, lactose to process.Wherein calcium contains
Measure as 24.0-28.0%.
Ferrous gluconate is derived from：Chemical synthesis is made, and wherein the content of iron is 12.5%.
Zinc gluconate is derived from：Calcium gluconae is initiation material, acidified to be reacted with zinc compound or with grape
Saccharic acid lactone is raw material and the obtained zinc gluconate of Zinc compounds reaction.Wherein the content of zinc is 14.26%.
Pregelatinized starch is derived from：Liaoning YingKou AODA Pharmaceutical CO.,LTD.
Formula
Seabuckthorn fruit extract 160g；Wolfberry fruit extract 100g；15g konjaku flours (equivalent to 10.5g SKGMs), 18g cherries
Peach powder (equivalent to 3g vitamin Cs), 80g cow's milk calcium powder (equivalent to 20g calcium), 5.6g ferrous gluconates are (equivalent to 0.7g
Iron), 4.2g zinc gluconates (equivalent to 0.6g zinc), 58.2g pregelatinized starch, 4.5g silica, 4.5g magnesium stearates.
Preparation method
Each component is weighed according to formula, it is standby；Sea buckthorn juice powder, wolfberry fruit extract, cow's milk calcium powder, cherry powder, konjaku
Powder, ferrous gluconate, zinc gluconate, pregelatinized starch adds magnesium stearate after silica mixing certain time and continued
It is well mixed.The material handled well is mixed into material uniform color discharging.Mould, grain weight 0.45g/ are filled using fixed
Grain, surveys sample capsule loading amount at regular intervals, when controlling capsule content uniformity, and checking capsule appearance and disintegration at any time
Limit, is produced.
Embodiment 13 promotes the preparation of the capsule of lead discharging
Experiment material
Seabuckthorn fruit extract (pulvis), i.e. sea buckthorn juice powder, from fructus hippophae is referred to through squeezing, sterilizing is settled, dried
Etc. process.
Wolfberry fruit extract (pulvis), passes through pure water refluxing extraction from matrimony vine is referred to.
Konjaku flour refers to that fresh konjak stem tuber is made by processing, is reached with the content of SKGM in gained konjaku flour
70% is defined.
Cherry powder refers to using acerola concentrate as raw material, mainly through the cherry made from technique such as enzymolysis, separation, concentration, dry
Powder, ascorbic content reaches that 17% is defined in gained cherry powder.
Cow's milk calcium powder is derived from：Whey is raw material, through going the compositions such as isolating protein, lactose to process.Wherein calcium contains
Measure as 24.0-28.0%.
Ferrous gluconate is derived from：Chemical synthesis is made, and wherein the content of iron is 12.5%.
Zinc gluconate is derived from：Calcium gluconae is initiation material, acidified to be reacted with zinc compound or with grape
Saccharic acid lactone is raw material and the obtained zinc gluconate of Zinc compounds reaction.Wherein the content of zinc is 14.26%.
Pregelatinized starch is derived from：Liaoning YingKou AODA Pharmaceutical CO.,LTD.
Formula
Seabuckthorn fruit extract 500g；Wolfberry fruit extract 1000g；71.4g konjaku flours (equivalent to 50g SKGMs), 588g
Cherry powder (equivalent to 100g vitamin Cs), 800g cow's milk calcium powder (equivalent to 200g calcium), 400g ferrous gluconates (equivalent to
50g iron), 70g zinc gluconates (equivalent to 10g zinc), water-soluble dietary fiber 500g, 480.6g pregelatinized starch, 45g dioxies
SiClx, 45g magnesium stearates.
Preparation method
Each component is weighed according to formula, it is standby；Sea buckthorn juice powder, wolfberry fruit extract, cow's milk calcium powder, cherry powder, konjaku
Powder, ferrous gluconate, zinc gluconate, water-soluble dietary fiber, pregelatinized starch, silica adds after mixing certain time
Enter magnesium stearate and continue well mixed.The material handled well is mixed into material uniform color discharging.Use fixed fill mould
Tool, grain weight 0.45g/, surveys sample capsule loading amount at regular intervals, controls capsule content uniformity, and check capsule at any time
Outward appearance and disintegration time limited, produce.
Embodiment 14 promotes the preparation of the capsule of lead discharging
Experiment material
Seabuckthorn fruit extract (pulvis), i.e. sea buckthorn juice powder, from fructus hippophae is referred to through squeezing, sterilizing is settled, dried
Etc. process.
Wolfberry fruit extract (pulvis), passes through pure water refluxing extraction from matrimony vine is referred to.
Konjaku flour refers to that fresh konjak stem tuber is made by processing, is reached with the content of SKGM in gained konjaku flour
70% is defined.
Cherry powder refers to using acerola concentrate as raw material, mainly through the cherry made from technique such as enzymolysis, separation, concentration, dry
Powder, ascorbic content reaches that 17% is defined in gained cherry powder.
Cow's milk calcium powder is derived from：Whey is raw material, through going the compositions such as isolating protein, lactose to process.Wherein calcium contains
Measure as 24.0-28.0%.
Ferrous gluconate is derived from：Chemical synthesis is made, and wherein the content of iron is 12.5%.
Zinc gluconate is derived from：Calcium gluconae is initiation material, acidified to be reacted with zinc compound or with grape
Saccharic acid lactone is raw material and the obtained zinc gluconate of Zinc compounds reaction.Wherein the content of zinc is 14.26%.
Pregelatinized starch is derived from：Liaoning YingKou AODA Pharmaceutical CO.,LTD.
Formula
Seabuckthorn fruit extract 1000g；Wolfberry fruit extract 500g；142.8g konjaku flours (equivalent to 100g SKGMs),
294g cherry powders (equivalent to 50g vitamin Cs), 2000g cow's milk calcium powder (equivalent to 500g calcium), 160g ferrous gluconate (phases
When in 20g iron), 350g zinc gluconates (equivalent to 50g zinc), water-soluble dietary fiber 1000g, 303.2g pregelatinized starch,
50g silica, 50g magnesium stearates.
Preparation method
Each component is weighed according to formula, it is standby；Sea buckthorn juice powder, wolfberry fruit extract, cow's milk calcium powder, cherry powder, konjaku
Powder, ferrous gluconate, zinc gluconate, water-soluble dietary fiber, pregelatinized starch, silica adds after mixing certain time
Enter magnesium stearate and continue well mixed.The material handled well is mixed into material uniform color discharging.Use fixed fill mould
Tool, grain weight 0.45g/, surveys sample capsule loading amount at regular intervals, controls capsule content uniformity, and check capsule at any time
Outward appearance and disintegration time limited, produce.
The evaluating drug effect of embodiment 15 is tested
Children's lead discharging effect experiment
Choosing 50 has a close contact lead history, Pb-B 10.0 μ g/dL (100 μ g/L) children, using itself and
Two kinds of control designs between group, test-meal group is by instructions of taking, dose daily sample is recommended, and control group takes placebo.By
Test agent gives the time 30 days.During experiment, do not change lifestyles, work and study environment does not change original life, and diet is practised
It is used.
The seabuckthorn fruit extract 500mg+ wolfberry fruit extract 800mg+ relevant auxiliary materials of test group 1
The seabuckthorn fruit extract 500mg+ wolfberry fruit extract 800mg+71.4g konjaku flours of test group 2 are (more equivalent to 50g konjakus
Sugar)+588g cherry powders (equivalent to 100g vitamin Cs)+800g cow's milk calcium powder (equivalent to 200g calcium)+400g ferrous gluconates
Other auxiliary materials of (equivalent to 50g iron)+70g zinc gluconates (equivalent to 10g zinc)+water-soluble dietary fiber 500g+
Influence (μ g/mL, x ± s) of the sample of table 3 to urinary calcium and urine zinc
After 30 days test, two test groups and control group are to urinary calcium and urine zinc discharge rate without significant changes (P>
0.05)。
Influence (μ g/dL, x ± s) of the sample of table 4 to blood lead
By the experiment of 30 days, the influence of test group 1 and test group 2 to blood lead all have statistical significance, experimental group 1 with
Control group is compared, P<0.05, the blood lead content of test group 2 is compared with control group, significant difference (P<0.01).
Influence (μ g/mL, x ± s) of the sample of table 5 to lead in urine
Remarks：* P is compared with control group<0.05, * * is compared P with control group<0.01, # before experiment with being compared P<0.05,##
Compared P with control group<0.01,
Test group 1 and test group 2 are compared with control group, and the influence to lead in urine all has statistical significance, wherein test group 1
10th, 20,30d with control group after significantly (P<0.05) notable (P behind, test group 2 the 10th, 20, with control group<0.05), 30d
With extremely significantly (P after control group<0.01).The influence of test group 1 and test group 2 to lead in urine is passed through after 10d, 20d with comparing before experiment
More significant (P<0.05), test group 2 is by experiment in 30 days and significantly (P before experiment<, and the experimental group time is longer, lead in urine 0.01)
Content it is higher, control group experiment before and after lead in urine change less (P>0.05).
Influence to immunity
Experimental animal and packet:Cleaning grade Male Kunming strain mice, body weight is 18-22g, totally 70, carries out delayed change
State reaction test, mouse antibodies cellulation number, NK cytoactive detections.
23 DEG C~25 DEG C of experimental situation Conditions Temperature, humidity 54%~68%
Key instrument and reagent:
Animal platform balance, assay balance, clean bench, CO2gas incubator, centrifuge, 722 spectrophotometers, constant temperature
Water bath, liquid glimmer instrument, microscope etc.；Sterile surgical instrument, slide measure, micro syringe, cell counter.
Reagent：Be three dosage groups by 2 points of above test group 1 and test group, each dosage group for human body recommended amounts (5,
10,20 times).
Sample to mouse weight, spleen/body weight, thymus gland/body weight influence difference all without conspicuousness (P>0.05) sample, is shown
Product increase on mouse weight without detail influence.
Influence of the sample of table 6 to mouse delayed allergy (DTH)
* compared with blank control group, P<0.05, * * is compared P with blank control group<0.01.
The middle and high dosage group of two test groups has statistical significance to mouse delayed allergy (DTH), wherein the
One test group (P<0.05), the second experimental group (P<0.01), showing that two samples all have promotes the delayed of mouse abnormal anti-
The effect answered.The sample effect of second test group is relatively preferable.
Influence of the sample of table 7 to mouse antibodies cellulation number
* compared with blank control group, P<0.05, * * is compared P with blank control group<0.01.
The middle and high dosage for there was only the second experimental group in two test groups has statistics meaning to mouse antibodies cellulation number
Justice (P<0.05), illustrate that this sample has fine effect to mouse antibodies cellulation number.
Influence of the sample of table 8 to NK cells in mice activity
* compared with blank control group, P<0.05, * * is compared P with blank control group<0.01.
First test group high dose and the second test group middle dose group are to NK cells in mice activity, with statistical significance (P
<0.05), the second test group high dose group is to NK cells in mice activity extremely significantly (P<0.01), NK cytoactives square root is anyway
String conversion value the second test group high dose group extremely significantly (P<0.01), agent in the middle and high dosage of the first test group and the second test group
Statistically significant (the P of measurer<0.05).Show that the sample is significantly improved to NK cells in mice activity.Two test groups are to small
Mouse all has the effect of strengthen immunity, and the effect of sample 2 is better than sample 1.
It the above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
The limitation of the present invention, protection scope of the present invention should be defined by claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (9)
1. a kind of composition of promotion lead discharging, it is characterised in that be made up of seabuckthorn fruit extract and wolfberry fruit extract；The sea-buckthorn
The mass ratio of berry extract and the wolfberry fruit extract is (1:3)~(2:1).
2. composition according to claim 1, it is characterised in that the seabuckthorn fruit extract and the wolfberry fruit extract
Mass ratio is (3:8)~(8:5).
3. composition according to claim 1 or 2, it is characterised in that its also include SKGM, vitamin C, calcium, iron,
One or both of zinc, water-soluble dietary fiber thing mixed above.
4. composition according to claim 3, it is characterised in that it is made up of the component of following parts by weight：
500~1000 parts of seabuckthorn fruit extracts, 500~1000 parts of wolfberry fruit extracts, 50~200 parts of SKGMs, 20~50 parts
Vitamin C, 50~200 parts of calcium, 6~20 parts of iron, 10~50 parts of zinc and 500~1500 parts of water-soluble dietary fibers.
5. the composition as any one of Claims 1-4 is preparing the application in promoting the health products or food of lead discharging.
6. a kind of food, it is characterised in that it includes the composition as any one of Claims 1-4.
7. a kind of health products, it is characterised in that it includes composition as any one of Claims 1-4 and pharmaceutically
Acceptable auxiliary material.
8. health products according to claim 7, it is characterised in that the pharmaceutically acceptable auxiliary material include flavouring,
One or both of filler, coating material, lubricant, disintegrant thing mixed above.
9. the health products according to claim 7 or 8, it is characterised in that its formulation is chewable tablets, coating tablet or capsule.
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| CN105192599A (en) * | 2015-08-14 | 2015-12-30 | 慧谷生命科技湖北有限公司 | Lead removing particles and preparation method thereof |
| CN105124593B (en) * | 2015-10-20 | 2017-07-11 | 王晓晓 | A kind of lead discharging food |
| CN105831771B (en) * | 2016-03-23 | 2019-04-23 | 江南大学 | A kind of dietary supplements with the probiotics and microelement of alleviating lead poisoning sexual function |
| CN105901741B (en) * | 2016-03-23 | 2019-03-19 | 江南大学 | A kind of dietary supplements with the probiotics and plant extracts of alleviating lead poisoning sexual function |
| CN106617114A (en) * | 2017-02-23 | 2017-05-10 | 青岛科技大学 | Chewable tablets containing kelp dietary fibre and calcium ions and preparation method thereof |
| CN107411104A (en) * | 2017-08-14 | 2017-12-01 | 安徽皓皓食品有限公司 | One kind promotes lead discharging extruding cake and preparation method |
| CN107802510B (en) * | 2017-11-14 | 2021-03-16 | 名臣健康用品股份有限公司 | Toothpaste composition with effects of promoting heavy metal discharge and enhancing immunity |
| CN109602837B (en) * | 2019-01-29 | 2021-04-20 | 哈工大机器人（山东）智能装备研究院 | Nano microcapsule with lead-removing function and preparation method thereof |
| JP7104926B1 (en) * | 2021-08-03 | 2022-07-22 | 宇航人ジャパン株式会社 | Agent for increasing helper T cells and food composition for increasing helper T cells |
| CN114504086A (en) * | 2022-02-28 | 2022-05-17 | 黑龙江飞鹤乳业有限公司 | Application of amazon berry |
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| CN1238008C (en) * | 2003-01-14 | 2006-01-25 | 江西江中药业股份有限公司 | Products for promoting human lead discharge and preparing method thereof |
| CN100366187C (en) * | 2006-01-04 | 2008-02-06 | 张东杰 | Health-care food for preventing and improving lead poisoning, and its prepn. method |
| CN101283722A (en) * | 2008-05-04 | 2008-10-15 | 王跃进 | Preparation method of coffee for enhancing intelligence |
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