CN100366187C - Health-care food for preventing and improving lead poisoning, and its prepn. method - Google Patents
Health-care food for preventing and improving lead poisoning, and its prepn. method Download PDFInfo
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- CN100366187C CN100366187C CNB2006100096067A CN200610009606A CN100366187C CN 100366187 C CN100366187 C CN 100366187C CN B2006100096067 A CNB2006100096067 A CN B2006100096067A CN 200610009606 A CN200610009606 A CN 200610009606A CN 100366187 C CN100366187 C CN 100366187C
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- 206010027439 Metal poisoning Diseases 0.000 title description 10
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Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a health food for preventing and relieving plumbism. Bean peptide obtained by being enzymolyzed, separated and purified from bean proteins is used instead of chitosan, and the molecular weight of the bean peptide is less than 2000; the bean peptide is mixed with a glycyrrhetic acid extracting solution, vitamins, a traditional Chinese medicine extracting solution, soluble zinc salt and soluble calcium powder, an excipient is added to prepare the health food for preventing and relieving the plumbism, and the health food performs protective action on organisms. The health food comprises the constituents in the fo1 lowing contents measured by weight percentage: 5 to 19% of bean peptide, 1 to 14% of glycyrrhetic acid, 20 to 60% of vitamins, 8 to 68% of traditional Chinese medicine extracting solution, 0.5 to 15% of soluble zinc salt and 0.5 to 20% of soluble calcium salt. Since the bean peptide contains a large quantity of base groups, such as hydroxy groups, amino groups, etc., the bean peptide has the capabilities of adsorption and collection for plumbum ions in a human body, and the plumbum ions are discharged out of the human body after being combined with the bean peptide to form stable chelates without any adverse effects on beneficial mineral elements, such as calcium, ferrum, zinc, etc., in the human body. Sulfur amino acids contained in the bean peptide can be converted into glutathione in cells to participate in the process of the detoxification of toxic substances and improve the bioavailability of the bean peptide.
Description
One, technical field: the invention belongs to health-care products, what be specifically related to is a kind ofly to contain beans peptide and Chinese medicinal ingredients, can prevent and improve saturnine health food and form and preparation method thereof.
Two, background technology: lead poisoning is one of hot issue of paying close attention to of food, nourishing healthy and medical educational circles to the harm of human body and prevention thereof and improvement always, and is especially more serious than the adult to children's harm.In absorbing plumbous main path-alimentary canal, the adult is 5%～10% to the absorptivity of lead, children are then up to 42%～53%, plumbous absorptivity in respiratory tract and lung also is grown up to high, be 1.6～2.7 times that are grown up approximately, store up the lead that stays in the brain as untimely elimination, the continuous maturation with growing may cause children's brain permanent lesion and feeblemindedness.The organ of lead poisoning mainly is hemopoietic system and heart, shows as influence erythrocytic functional lifetime, disorderly heart vegetative nerve, the new albumen that plays a crucial role in the long-term memory is synthetic to forming in damage, cranial nerve cell and infringement renal tubular function etc.Because lead poisoning does not have significantly in the early stage mostly and the typical clinical features performance, its generation and development are more hidden.At present, in clinical and health care, mainly be to adopt Western medicine to treat agent and Chinese medicinal formulae prevention and treatment lead poisoning.Common technological means is to drive plumbous treatment with the complexing medicine, specifically is by driving plumbous medicine in conjunction with the lead in blood and the tissue, plumbous bond with medicine is discharged through urine or stool, reach and reduce lead load in the body, stoping plumbous the continuation the effect of body toxigenicity.Comparatively Chang Yong complexing medicine is mainly following two classes: 1, the competitive antidote of sulfydryl (DMSA) class, with active sulfydryl capture with cell and enzyme system in the lead that combines, promote plumbously to dissociate and get rid of, the decorporation of other useful metal ions is had certain selectivity from tissue.2, egg carboxylic complexing (EDTA) metalloid chelating agent is driven away with carboxyl and plumbous chelating, can with the part competition heavy metal in the body, and be combined into big molecule chelate with heavy metal.So both can prevent heavy metal ion to combine, can also separate the heavy metal ion that has combined with part in the body with part in the body.The problem that exists is: lead discharging is not thorough in addition to drive plumbous non-selectivity, makes the lead that is accumulated in bone tissue and internal organs enter blood again under certain condition, causes the Lead Toxicity infringement once again.
Chinese patent CN1465285A discloses a kind of lead-removing health care food and preparation method thereof.Should middle health food be solid-state health products, and mainly be to close absorption by the effective huge legendary turtle of macromolecular substances such as shitosan to quicken plumbous eliminating, thereby reach the purpose of detoxifcation.Yet, the process complexity that shitosan extracts, the shitosan price after the extraction is expensive.Therefore, the health food of development and utilization wholefood medicine source material is applied to not reach crowd's prevention of poisoning clinical treatment standard for a certain amount of lead of body accumulation and improve lead poisoning, has even more important meaning.
Three, summary of the invention: the objective of the invention is provides a kind of saturnine health food and preparation method thereof that prevents and improve at the problems referred to above; this health food replaces shitosan with low molecule beans peptide; mix with glycyrrhizic acid, vitamin, Chinese medicine extract, soluble zinc salt, soluble calcium salt; contain a large amount of carboxyls, amino and pure hydroxyl in the product of producing and swash the isoreactivity group; can close other useful mineral element of balance in harmful heavy ions such as lead, ion concentration huge legendary turtle; be used for prevention and improve lead poisoning, body is played a protective role.
The present invention is achieved by the following technical programs:
(1) component of health food and content
Prevention and improve saturnine health food and mainly comprise beans peptide, glycyrrhizic acid, vitamin, Chinese medicine extract, soluble zinc salt, soluble calcium salt, its component and content are by weight percentage: beans peptide (A component) is 5～19%, glycyrrhizic acid (B component) is 1～14%, vitamin (C component) 20～60%, Chinese medicine extract (D component) 8～68%, soluble zinc salt (E component) 0.5～15%, soluble calcium salt 0.5～20% (F component).
Above-mentioned component and content are by weight percentage: beans peptide (A component) is 8～15%, glycyrrhizic acid (B component) is 5～11%, vitamin (C component) 25～60%, Chinese medicine extract (D component) 12～59%, soluble zinc salt (E component) 1.2～8%, soluble calcium salt (F component) 1.5～10%.
A component in the scheme is that enzymolysis separate to be purified the molecular weight that obtains less than 2000 beans peptide from legumin; B component market sale 98% pure product; The C component is a kind of of Cobastab, C or E; The D component is the extract of Poria cocos, matrimony vine, chrysanthemum, rhizoma alismatis, pawpaw or Asiatic plantain, and extract concentration is 400～850 mg/litre; The E component is zinc acetate, zinc chloride, zinc gluconate, animal bone zinc; The F component is calcium acetate, calcium chloride, calcium gluconae and animal bone calcium (powder).
B component preferred weight percentage concentration was 5～11% (also can replace product with commercially available pure product).Product purity 98%.
D component in the scheme is two or more mixed extracts of Poria cocos, matrimony vine, chrysanthemum, rhizoma alismatis, pawpaw or Asiatic plantain.
During preparation, the each component sum in the scheme is 100%.
(2) preparation method:
1, the preparation of component
A component (molecular weight less than 2000 beans peptide): preferred weight percentage is that the condition that 8～15% beans peptides are produced is: preferred 35～65 ℃ of hydrolysis temperature, and pH preferred 7.5～10 during enzymolysis; Preferred 2.5～5h of hydrolysis time time; The concentration of soybean protein preferred 3～7%; Alkali protease (Alcalase) addition 1% (W/V); The control temperature range of enzymolysis preferably is spray dried to Powdered under 65～85 ℃.
D component (Chinese medicine extract): adopt traditional water formulation second extraction to prepare Chinese medicine extract.Concrete preparation is to add 10 times of warm water to dose to boil, and water temperature is controlled at 60～95 ℃, and (0～20mbar) is concentrated into 1/3～4/5 of original volume, and concentration is 400～850 mg/litre (preferred 500～650 mg/litre) to merge extracted twice liquid final vacuum.For example: Chinese medicine matrimony vine chrysanthemum soaked 6 hours by 1: 2 weight ratio, the traditional hot reflow method extracts secondary, adding 10 times of warm water to dose boils, water temperature is controlled at 80 ℃, merge extracted twice liquid final vacuum and be concentrated into 1/3 of original volume, concentration is 750 mg/litre, and the normal temperature high voltage sterilization is stand-by after 5 minutes.
Wherein: B (purity 98%), C, E, F component are commercially available finished product, and the D component can be made by oneself, also can buy commercially available finished product.
2, the preparation of health food
(1) earlier vitamin and beans peptide are evenly mixed;
(2) the D component is produced by Chinese medicine extract, normal temperature, autoclaving are stand-by after 5 minutes;
(3) (1) and (2) is evenly mixed in proportion, being stirred to solution does not have precipitation and suspension, and making color is dark-brown mixed solution.
(4) the powdering preparation of placing or spray is preserved in the sterilization of (3) normal temperature high voltage.
Mixed solution that said method makes or powderous preparations add the excipients that accounts for gross weight 0～5% again.Used excipients can be selected pectin for use, Arabic gum, one or more in lactose, honey, stearic acid, the sweet mellow wine.
The present invention uses from legumin enzymolysis to separate to purify the molecular weight that obtains to mix with glycyrrhizic acid extract, vitamin, Chinese medicine extract, soluble zinc salt, soluble calcium salt less than 2000 beans peptide and adds excipients and make by above-mentioned composition, content and preparation method, beans peptide during product is formed contains a large amount of sulfur-containing amino acid, in cell, can be converted into glutathione, participate in the poisonous substance detoxification processes, increase its bioavailability.Owing to contain a large amount of hydroxyls, amino groups in the beans peptide, lead ion in the human body is had absorption and trapping ability, and behind the stable a flat iron plate for making cakes compound of its formation it is excreted, and, but have no adverse effects beneficial mineral elements such as calcium, iron and zinc in the human body.Multiple organic acids such as butanedioic acid, tartaric acid, pectic acid are rich in glycyrrhizic acid and decomposition glucoside unit thereof, and strong complexing of organic acid and part anti-inflammatory diuresis function play lead discharging; Vitamin in the C component can promote lead to dissociate and drainage aspect drive away lead poisoning, especially Cobastab, C can constitute chelate ring by hydroxyl wherein or the C=O base that is formed by two molecule vitamins, generate soluble complex with plumbous the combination, strengthen the lead-dispelling effect of chelating agent.The employed Chinese medicine of D component, it is eliminating evil to base oneself upon detoxifcation, is aided with invigorating the spleen and sets upright, and makes drink can reduce the lead load of body effectively.Compare with Western medicine, adverse side effect is little, lead discharging selectivity height advantages such as (the metabolic process influence to other element are less), especially contained active component of Chinese medicine and trace element are of a great variety, therefore Chinese medical extract is held concurrently in drink and is all prevented and treatment, and can play the Total tune effect, can prevent and improve lead poisoning after eating.
This health functional food also can be used for preventing and treating the poisoning symptom of mercury, cadmium etc.
The present invention has the following advantages and beneficial effect: the present invention passes through a, external pharmacodynamics test: artificial in-vitro simulated manufacturing gastric environment, under similar acidity and ionic strength conditions, carry out, and observe the huge legendary turtle of this health food treadle-operated tilt hammer for hulling rice lead ion close adsorption capacity; Pharmacodynamics test in b, the animal body: select 120 of other male cleaning level Male Kunming strain mice of unicity for use, body weight 18～20g, be 1～2 week reproduction age, adaptability is divided into 6 groups by body weight after raising a week.Experimental session, 12h throws light at interval, and at 20 ℃, humidity is to observe, test under 50% the condition, proves to have the following advantages and good effect:
1, contain a large amount of hydroxyls and carboxyl in little molecule beans peptide, vitamin and the Chinese traditional medicine biology active component of Shi Yonging, can be bonded to big molecule by calcium ion, form various forms of hydrogen bond associations, drink adsorpting lead ion amount is big.
2, drink of the present invention can also be replenished the calcium and zinc in decorporation lead, strengthens immunologic function, and that coordinates iron absorbs and regulate cholesterol metabolic, is improving and the prevention lead poisoning, effectively can replenish zinc and calcium constituent in the decorporation lead.
3, the each component among the present invention is drawn materials from natural medicine-food homology material, and the health products of producing have human body is had no side effect, drinks conveniently, takes into account saturnine prevention and treatment, cost is low.
Four, the specific embodiment:
Embodiment 1:
Earlier molecular weight is fully mixed less than 2000 Soybean Peptide 10%, glycyrrhizic acid 5%, vitamin C 30%, zinc chloride 1.2% and calcium chloride 1.8%; Chinese medicine matrimony vine, chrysanthemum soaked 6 hours by 1: 2 weight ratio, the traditional hot reflow method extracts secondary, adding 10 times of warm water to dose boils, water temperature is controlled at 80 ℃, merge extracted twice liquid final vacuum and be concentrated into 2/3 of original volume, concentration is the Chinese medicine extract of 580 mg/litre, and the normal temperature high voltage sterilization is stand-by after 5 minutes.The solid mixture and the 52% Chinese medicine extract magnetic force of Soybean Peptide, glycyrrhizic acid, vitamin C, calcium chloride and zinc chloride are added thermal agitation, and temperature is at 45 ℃, and evenly being mixed to solution does not have precipitation and suspension, till color is dark brown, and normal temperature high voltage sterilization, can.
Embodiment 2:
Earlier molecular weight is fully mixed less than 1000 Soybean Peptide 8%, glycyrrhizic acid 6%, vitamin B2 8%, Shark cartilage calcium salt 2.5% and zinc gluconate 1.8%; Chinese medicine Poria cocos, pawpaw and chrysanthemum soaked 9 hours by 2: 1 weight ratios, the traditional hot reflow method extracts secondary, adding 10 times of warm water to dose boils, water temperature is controlled at 89 ℃, merge extracted twice liquid final vacuum and be concentrated into 3/5 of original volume, concentration is the Chinese medicine extract of 580 mg/litre, and the normal temperature high voltage sterilization is stand-by after 5 minutes.The solid mixture and the heating of 53.7% traditional Chinese medicine extraction fluid power of Soybean Peptide, glycyrrhizic acid, Cobastab, Shark cartilage calcium salt and zinc gluconate are stirred, temperature is at 40 ℃, also can add 3.5% Arabic gum evenly be mixed to solution do not have the precipitation and suspension, till color was dark brown, the normal temperature high voltage sterilization was preserved and is placed.
Embodiment 3:
Earlier molecular weight is fully mixed less than 2000 mung bean peptide 10%, glycyrrhizic acid 5%, vitamin E 32%, calisanin 5% and zinc acetate 3%; Chinese medicine matrimony vine Poria cocos soaked 8 hours by 1: 2 weight ratio, the traditional hot reflow method extracts secondary, adding 10 times of warm water to dose boils, water temperature is controlled at 85 ℃, merge extracted twice liquid final vacuum and be concentrated into 4/5 of original volume, concentration is the Chinese medicine extract of 440 mg/litre, and the normal temperature high voltage sterilization is stand-by after 5 minutes.The solid mixture and the 59% Chinese medicine extract magnetic force of Soybean Peptide, glycyrrhizic acid, vitamin E, calisanin and zinc acetate are added thermal agitation, temperature is at 51 ℃, also can add 3% pectin evenly be mixed to solution do not have the precipitation and suspension, till color is dark brown, be spray dried to pulvis.
Embodiment 4:
Earlier Soybean Peptide 8%, glycyrrhizic acid 7%, Catergen 5%, calcium acetate 3% and the zinc acetate 3% of molecular weight in the 780-1500 part fully mixed; Chinese medicine rhizoma alismatis and Asiatic plantain were soaked 8 hours by 1: 2 weight ratio, the traditional hot reflow method extracts secondary, adding 10 times of warm water to dose boils, water temperature is controlled at 85 ℃, merge extracted twice liquid final vacuum and be concentrated into 3/4 of original volume, concentration is the Chinese medicine extract of 480 mg/litre, and the normal temperature high voltage sterilization is stand-by after 5 minutes.The solid mixture and the 54% Chinese medicine extract magnetic force of Soybean Peptide, glycyrrhizic acid, vitamin C, calcium acetate and zinc acetate are added thermal agitation, temperature is at 38 ℃, also can add 4% stearic acid evenly be mixed to solution do not have the precipitation and suspension, till color is dark brown, make powder, add the plumbous health food of one-tenth decorporation in the food to.
Embodiment 5:
Earlier molecular weight is fully mixed less than 1500 Soybean Peptide 12%, glycyrrhizic acid 7%, vitamin E 35%, shark calcium salt 2.9% and zinc acetate 1.7%; Chinese medicine chrysanthemum and rhizoma alismatis were soaked 8 hours by 2: 1 weight ratios, the traditional hot reflow method extracts secondary, adding 10 times of warm water to dose boils, water temperature is controlled at 85 ℃, merge extracted twice liquid final vacuum and be concentrated into 2/3 of original volume, concentration is the Chinese medicine extract of 530 mg/litre, and the normal temperature high voltage sterilization is stand-by after 5 minutes.The solid mixture and the 49.4% Chinese medicine extract magnetic force of Soybean Peptide, glycyrrhizic acid, vitamin E, calcium acetate and zinc acetate are added thermal agitation, temperature is at 50 ℃, add Arabic gum and pectin etc. and evenly mix, do not have precipitation and suspension to solution till, make pulvis and capsule.
Embodiment 6:
Earlier molecular weight is fully mixed less than 1500 black soya bean peptide 8%, glycyrrhizic acid 5%, vitamin B2 5%, calcium chloride 6% and zinc gluconate 2.8%; Chinese medicine chrysanthemum and rhizoma alismatis were soaked 8 hours by 1: 2 weight ratio, the traditional hot reflow method extracts secondary, adding 10 times of warm water to dose boils, water temperature is controlled at 85 ℃, merge extracted twice liquid final vacuum and be concentrated into 1/2 of original volume, concentration is the Chinese medicine extract of 610 mg/litre, and the normal temperature high voltage sterilization is stand-by after 5 minutes.The solid mixture and the 53.2% Chinese medicine extract magnetic force of Soybean Peptide, glycyrrhizic acid, Cobastab, calcium acetate and zinc gluconate are added thermal agitation, and temperature adds Arabic gum and pectin etc. and evenly mixes at 55 ℃, adds an amount of disintegrant, makes tablet.
Embodiment 7:
Earlier molecular weight is fully mixed less than 1000 Soybean Peptide 8%, glycyrrhizic acid 8%, vitamin B2 9%, Shark cartilage calcium salt 5.5% and zinc gluconate 3.5%; Chinese medicine Poria cocos, pawpaw and chrysanthemum soaked 7 hours by 2: 1: 1 weight ratios, the traditional hot reflow method extracts secondary, adding 10 times of warm water to dose boils, water temperature is controlled at 87 ℃, merge extracted twice liquid final vacuum and be concentrated into 3/5 of original volume, concentration is the Chinese medicine extract of 580 mg/litre, and the normal temperature high voltage sterilization is stand-by after 5 minutes.The solid mixture and the 46% Chinese medicine extract magnetic force of Soybean Peptide, glycyrrhizic acid, Cobastab, Shark cartilage calcium salt and zinc gluconate are added thermal agitation, temperature is at 45 ℃, also can add honey 4% evenly be mixed to solution do not have the precipitation and suspension, till color was dark brown, the normal temperature high voltage sterilization was preserved and is placed.
Claims (6)
1. one kind is prevented and improves saturnine health food, it is characterized in that: this health food mainly comprises beans peptide, glycyrrhizic acid, vitamin, Chinese medicine extract, soluble zinc salt, soluble calcium salt, and its component and content are by weight percentage: beans peptide A component 5～19%, glycyrrhizic acid B component 1～14%, vitamin C component 20～60%, Chinese medicine extract D component 8～68%, soluble zinc salt E component 0.5～15%, soluble calcium salt F component 0.5～20%; Described Chinese medicine extract is the extract of Poria cocos, matrimony vine, chrysanthemum, rhizoma alismatis, pawpaw or Asiatic plantain, and extract concentration is 400～850 mg/litre.
2. prevention according to claim 1 and improve saturnine health functional food, it is characterized in that: above-mentioned component and content are by weight percentage: beans peptide A component is 8～15%, glycyrrhizic acid B component is 5～11%, vitamin C component 25～60%, Chinese medicine extract D component 12～59%, soluble zinc salt E component 1.2～8%, soluble calcium salt F component 1.5～10%.
3. prevention according to claim 1 and 2 and improve saturnine health functional food is characterized in that: the beans peptide is that enzymolysis separates to purify and obtains from legumin, and molecular weight is less than 2000.
4. prevention according to claim 1 and 2 and improve saturnine health food, it is characterized in that: vitamin is vitamin C, Cobastab or vitamin E.
5. prevention according to claim 1 and 2 and improve saturnine health food, it is characterized in that: Chinese medicine extract is selected two or more of Poria cocos, matrimony vine, chrysanthemum, rhizoma alismatis, pawpaw and Asiatic plantain for use.
6. prevention according to claim 1 and 2 and improve saturnine health food, it is characterized in that: soluble zinc salt is selected from zinc acetate, zinc chloride, zinc gluconate or animal bone zinc; Soluble calcium salt is selected from calcium acetate, calcium chloride, calcium gluconae or animal bone calcium.
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| CN100998742B (en) * | 2006-12-25 | 2010-09-15 | 刘秀萍 | Traditional Chinese medicine decoction for treating lead poisoning |
| CN102726721A (en) * | 2011-12-21 | 2012-10-17 | 聂存良 | Balanced trace element lead-removing oral liquid |
| CN103190506A (en) * | 2013-04-25 | 2013-07-10 | 北京绿源求证科技发展有限责任公司 | Food health tea electuary capable of promoting lead detoxification |
| CN103211065B (en) * | 2013-05-10 | 2014-02-12 | 北京绿源求证科技发展有限责任公司 | Pabular health tea electuary for promoting lead excretion |
| CN103250841A (en) * | 2013-06-07 | 2013-08-21 | 北京绿源求证科技发展有限责任公司 | Food health protection tea electuary for promoting discharging of lead |
| CN104257887B (en) * | 2014-10-22 | 2017-11-07 | 汤臣倍健股份有限公司 | A kind of composition for promoting lead discharging and its application |
| CN106539093A (en) * | 2017-01-13 | 2017-03-29 | 王卫东 | A kind of gene repair fully nutrient |
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| CN1181204A (en) * | 1996-11-04 | 1998-05-13 | 青岛海洋大学 | Bean milk powder for removing lead |
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