CN102379415A - Antioxidant healthcare capsule and preparation method thereof - Google Patents
Antioxidant healthcare capsule and preparation method thereof Download PDFInfo
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- CN102379415A CN102379415A CN2010102674922A CN201010267492A CN102379415A CN 102379415 A CN102379415 A CN 102379415A CN 2010102674922 A CN2010102674922 A CN 2010102674922A CN 201010267492 A CN201010267492 A CN 201010267492A CN 102379415 A CN102379415 A CN 102379415A
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Abstract
The invention relates to an antioxidant healthcare capsule and a preparation method thereof. The capsule is made of grape seed extract, tea polyphenol, chitosan, vitamin E, vitamin C and fillers. The method comprises the steps of: 1) weighing all components according to proportions; 2) crushing the grape seed extract, the tea polyphenol and the chitosan, passing through an 80-mesh sieve and mixing to obtain mixed powder A; 3) passing the vitamin E, the vitamin C and starch through the 80-mesh sieve and mixing to obtain mixed powder B; 4) evenly mixing the mixed powder A and the mixed powder B through an equivalent increasing method to obtain overall mixed powder; and 5) filling the overall mixed powder into capsules. The antioxidant healthcare capsule has the advantage of antioxidation.
Description
Technical field
The present invention relates to a kind of anti-oxidation health capsule and preparation method thereof.
Background technology
At present, China formally gets into " aged epoch ", and the elderly is because health is constantly old and feeble, and resistance descends, and is very easily sick, and quality of life reduces.In the face of this huge elderly population, set up the prevention from suffering from the diseases consciousness of putting prevention first, could be from the most fundamentally improving the life in old age quality, therefore, the health care demand of elderly population is more much bigger than the population of other age brackets, and is much also more urgent.
Summary of the invention
The technical problem that the present invention will solve provides a kind of anti-oxidation health capsule and preparation method thereof.
Technical scheme of the present invention is:
A kind of anti-oxidation health capsule, its special character is: comprise the capsule that grape seed extract, Tea Polyphenols, shitosan, vitamin E, vitamin C and filler are processed.
Above-mentioned filler is a starch.
Above-mentioned each constituent content is:
Grape seed extract 37.5g
Tea Polyphenols 150g
Shitosan 82.5g
Vitamin E 4.5g
Vitamin C 4g
Starch 21.5g.
A kind of preparation is the method for capsule according to claim 1, and its special character is to comprise following steps:
1), claims grape seed extract, Tea Polyphenols, shitosan, vitamin E, vitamin C and starch by formula rate;
2), grape seed extract, Tea Polyphenols and shitosan pulverized 80 mesh sieves, fine powder; Grape seed extract, Tea Polyphenols and shitosan fine powder mix 20 minutes to evenly, get mixed powder A;
3), vitamin E, vitamin C and starch crosses 80 mesh sieves, fine powder; Vitamin E, vitamin C and starch dust mix about 20 minutes to evenly, get mixed powder B;
4), mixed powder A and mixed powder B are mixed to evenly with the equivalent incremental method again, total mixed powder;
5), with total mixed powder filled capsules.
Above-mentioned steps 5) in, loading amount is the 0.3g/ grain, the bottling of polishing back, and certified products carry out external packing after the quality inspection, the finished product warehouse-in.
Above-mentioned steps 1)～step 5) accomplishes in 100,000 grades of clean areas.
Technique effect of the present invention is:
1, anti-oxidant.
2, capsule can carry at any time, can take at any time, and dose is definite; Constant product quality does not need special holding conditions simultaneously, does not receive the restriction of time, place and condition; Conveniently take, covered poor taste, make the consumer be easier to accept through capsule.
3, the raw materials used solid forms that is of this product is suitable for processing capsule, is material powder and external isolation through processing the bottling of capsule grain; Do not receive effects such as water in air branch, oxygen, it is rotten to be difficult for the moisture absorption, can cover disagreeable taste; Supplementary product consumption is few simultaneously; Technology is simple, and cost is lower, good stability.
The specific embodiment
Health food of the present invention has anti-oxidation function, and to this function, primary raw material used in the present invention has: grape seed extract, Tea Polyphenols, shitosan, vitamin E and vitamin C all have clear and definite anti-oxidant pharmacology effect.
Fill a prescription as follows:
Grape seed extract 37.5g
Tea Polyphenols 150g
Shitosan 82.5g
Vitamin E 4.5g
Vitamin C 4g
Starch 21.5g
Amount to 300g, process 1000, the 0.3g/ grain.
Grape seed extract is the one type of material with certain effect that from the seed of grape, extracts.The OPC compound that is rich in grape pip or the claret not only has very strong non-oxidizability, but also has many effects relevant with non-oxidizability, like Prevention of Cardiovascular illness, inhibition tumour etc.Existing research shows, grape seed extract have anti-inflammatory, antirheumatic, antiallergic action, antitumor, alleviate ischemical reperfusion injury, alzheimer's disease and Parkinson's disease development process and regulate the vascular cell function, suppress LDL oxidation and reduce protective effects such as platelet aggregation delay senility, slow down.Up to the present, from grape pip, isolate the number of chemical composition, related generally to fatty oils, flavones and polyatomic phenol etc.Flavones and polyhydric phenols mainly are the oligomer of flavanoid and OPC.OPC is a kind of powerful antioxidant and strong free radical scavenger, mainly is made up of through valence link construction units such as catechin, epicatechin or texifolins, is divided into monomer, oligomer and many bodies according to the number of construction unit.This type of anti-oxidant is to the capture ability of free radical, even is greater than classical vitamins anti-oxidant.The consumption of grape seed extract is 150mg/ days in this prescription, and wherein procyanidin content is 60% (mass percent).OPC compound in the grape pip is one of active ingredient in the grape pip of generally acknowledging at present, therefore classifies OPC one of as functional component.
Tea Polyphenols is the complex that separates more than the 30 kind of phenolic compound of purifying in the natural plants tealeaves, accounts for 20%～30% of tealeaves dry matter weight.Tea polyphenolic compounds comprises flavanols, flavandiols, flavonoids and 4 types of materials of phenolic acid.The promptly common alleged catechin of flavanols accounts for 70% of Tea Polyphenols.Catechin mainly comprises Epigallo-catechin gallate (EGCG) (EGCG), epigallocatechin (EGC), L-Epicatechin gallate (ECG), epicatechin (EC), nutgall catechin and catechin; Wherein EGCG content is the highest, accounts for 80% of catechin.That Tea Polyphenols has is antitumor, reducing blood lipid, antiatherosclerosis, cardiac stimulant, anti-arrhythmia, multiple biologically active such as anti-ageing and antibiotic, and these biologically actives are all relevant with its antioxidation.Tea Polyphenols is a kind of good natural, and also there are synergy in Tea Polyphenols and other anti-oxidants, like Vc, V
E, carotenoid and glutathione etc., these synergies have strengthened the antioxidant effect of Tea Polyphenols.Its anti-oxidant mechanism is for directly removing active oxygen radical, suppress peroxidatic reaction of lipid, inducing the interior anti-oxidative defense system of transition metal ions complexing, active cell of oxidation.The consumption of Tea Polyphenols is 360mg/ days in this prescription.
Shitosan (chitosan) is that chitin (chidn) in shellfish (like shrimp, crab), insect and other invertebrate shells is through the deacetylated a kind of natural macromolecule amylose body that makes; Medical circle is its 6th vital principle of being described as needed by human after sugar, protein, fat, vitamin, mineral matter (inorganic salts), has advantages such as nontoxic, good biocompatibility, degradable.Shitosan has lipopenicillinase, antibiotic, antitumor, anticoagulant, antiacid, antiulcer, anti-oxidant isoreactivity.Shitosan can alleviate the peroxidatic reaction of lipid due to the endogenous free radical that produces after the motion effectively, strengthens oxidation resistance.Vitamin C suppresses the fat digestion absorption to shitosan and plays synergy; Under the sour environment of stomach, vitamin C can make just degree reduction of shitosan, and just shitosan mixes with fatty material more fully; Under the alkaline environment of small intestine; Vitamin C can promote the formation of chitosan gel rubber, strengthens the ability of bound fat and the activity that reduces sterol, makes fat and cholesterol be difficult for being excreted by little intestinal absorption.So when taking shitosan, add vitamin C, will play synergy to lipopenicillinase.Shitosan is a kind of stable raw material, in batching, belongs to booster action.
Vitamin E (V
E) be a kind of liposoluble vitamin, have the high-efficiency antioxidant effect, the major physiological function is an antioxidation.Protect cell to avoid free radical damage in vivo.Vitamin E is antioxidant system in superoxide dismutase, glutathione peroxidase constituting body; Protection biomembrane (comprising cell membrane, organelle film) is gone up the sulfydryl of poly aliphatic acid, cytoskeleton and other protein and is avoided the free radical attack, therefore has a series of physiological actions: 1. anti arteriosclerosis effect; 2. antitumaous effect; 3. raising immunity.
Vitamin C (Vc) is a kind of water soluble vitamin, is to keep normal human's metabolism and the requisite material of physiological function.Human body is because of lacking lipoxidase in the gulose, self can not synthetic vitamin C, must obtain vitamin C from meals.Vitamin C has different physiological roles in human body: 1. the confactor of dihydroxylation process substrate and enzyme; 2. antioxidation; 3. promote that iron absorbs; 4. raising immunity of organisms.Vitamin C is a kind of reversible low molecule polyphenoils, and many-sided anti-oxidation function is arranged, and it mainly acts on is to shift through electronics to make the vitamin E free radical recover reducing activity.Vitamin E and vitamin C are united the oxidation resistance that use can be strengthened vitamin E.
Starch (auxiliary material) serves as filler in this prescription, have good flowability.
Product form of the present invention mainly adopts raw meal to mix filled hard capsules, processes capsule preparations commonly used in the modern pharmaceutical.Production technology is pressed the hard capsule design, has taked solid material is pulverized, and mixes encapsulated process route.Starch is filler, and no consumption restriction on pharmacy is so confirm consumption according to the technology actual needs.
In the selected recipe ingredient: (by percentage to the quality)
Grape seed extract, its procyanidin content are >=60%;
Tea Polyphenols, its polyphenol content are >=60%;
Shitosan, its deacetylation >=85%;
Vitamin E, its content of vitamin E are >=40%;
Vitamin C, its Vitamin C content are >=93.0%.
Product processes involved in the present invention is following:
1, claims grape seed extract, Tea Polyphenols, shitosan, vitamin E, vitamin C and starch by formula rate;
2, grape seed extract, Tea Polyphenols and shitosan were pulverized 80 mesh sieves, got fine powder; Grape seed extract, Tea Polyphenols and shitosan fine powder mix 20 minutes to evenly, get mixed powder A;
3, vitamin E, vitamin C and starch are crossed 80 mesh sieves, get fine powder; Vitamin E, vitamin C and starch dust mix about 20 minutes to evenly, get mixed powder B;
4, mixed powder A and mixed powder B are mixed to evenly with the equivalent incremental method again, get total mixed powder;
5, with total mixed powder filled capsules, loading amount is the 0.3g/ grain, polishing, and bottling (being 60/bottle), quality inspection, certified products carry out external packing, the finished product warehouse-in.
Step 1～5 need in 100,000 grades of clean areas, to accomplish.
Embodiment one:
1, sample:
Capsule involved in the present invention.
2, dosage design:
These article human body recommended amounts is 1.2g/60kg every day.Basic, normal, high three dose groups are established in this experiment, are respectively 0.10,0.20,0.60g/kg, are equivalent to 5 times, 10 times and 30 times of human dose respectively.Other establishes the distilled water control group.
3, sample treatment:
Sample thief 0.10,0.20,0.60g, adding distil water makes into even suspension to 10ml respectively, is the test liquid of basic, normal, high three dosage.
4, animal used as test:
Rat, 12 monthly ages, body weight 400～500 grams, male.20～25 ℃ of laboratory animal breeding room's temperature, relative humidity 40～70%.
5, provisions approach:
Irritate stomach, irritate stomach volume 1ml/100g.
6, experimental technique and result:
Each dose groups is given sample, and control group is irritated stomach with distilled water, continuous 30 days.The 31st day, 4 treated animals are plucked eyeball and got blood, and were centrifugal, get serum.Measure following biochemical indicator: lipid peroxide catabolite MDA (MDA) content, (SOD) vigor of superoxide dismutase in the blood and glutathione peroxidase (GSH-Px) in the blood.Experimental result is added up with Spss software.
Sample is to the influence of the weight of animals
Visible by last table, each dose groups of sample is compared with aged control, difference that there are no significant.
Lipid peroxide catabolite MDA (MDA) content in the blood
Visible by last table, sample 0.60g/kg dose groups is compared with aged control, and significant difference is arranged.(SOD) vigor of superoxide dismutase in the blood and glutathione peroxidase content
Visible by last table, superoxide dismutase (SOD) vigor and glutathione peroxidase (GSH-Px) content are compared with aged control in sample 0.20g/kg, the 0.60g/kg dose groups blood, and significant difference is all arranged.
7, conclusion:
Sample has anti-oxidation function to animal.
Embodiment two:
1, materials and methods
1.1, sample:
Capsule involved in the present invention, human body recommended intake are 0.3g * 4/ day/people.
1.2, experimenter crowd:
Select to meet criterion person by the principle of voluntariness.
1.2.1, experimenter's choice criteria:
Select age at 45～65 years old, physical condition is good, does not have obvious brain, the heart, liver, lung, kidney, blood illness, does not have the history of taking medicine for a long time, the elderly that aspiration is tried and guaranteed to cooperate.
1.2.2, experimenter's exclusion standard:
Pregnancy period or women breast-feeding their children; Be associated with serious disease patients such as cardiovascular, liver, kidney and hemopoietic system; Took the article person relevant in 30 days with being tried function; Not by the regulation person that takes the given the test agent; Data is not judged effect or security person completely without method.
1.3, experimental design and grouping:
The experimenter is divided into each 55 people of test-meal group and control group at random, considers to influence result's principal element such as age, sex, living and diet custom etc. as far as possible, with the comparativity between the assurance group.Adopt two kinds of research methods of contrast between self cross-reference and group.Test back rejects by exclusion standard that the test-meal group is 51 people behind 5 people, and control group is 54 people.
1.4, taking dose and time:
The test-meal group is obeyed 1.2g (4 of every days) everyone every day, takes continuously 3 months.Control group is not done any processing.The duration of test experimenter does not change original life and eating habit, normal diet.
1.5, observation index
1.5.1, general situation:
Comprise spirit, sleep, diet, stool and urine, blood pressure of experimenter etc.
1.5.2, safety indexes:
Routine blood test, stool and urine routine, the fluoroscopy of chest of X line, Abdominal B type ultrasonography, electrocardiogram, liver function, renal function etc.
1.5.3, effect property index:
1.5.3.1, lipid peroxide content.
1.5.3.2, superoxide dismutase.
1.5.3.3, glutathione peroxidase.
1.6, the experimental data statistical analysis:
Use medical science encyclopedia statistical package (PEMS3.1) to carry out statistical analysis.The relatively employing paired t-test of difference before and after each index test.Test the relatively employing two sample mean t check of forward and backward test-meal group and control group group difference, adopt t ' check during heterogeneity of variance.
2, result
2.1, general situation:
Duration of test experimenter's spirit, diet, sleep, stool and urine etc. are no abnormality seen all.
2.2, the safety indexes observed result:
The preceding two groups of subject age of examination trencherman, sex all do not have significant difference (P＞0.05), and data was relatively seen table 1 as test-meal was last.Duration of test experimenter's spirit, diet, sleep, stool and urine situation etc. are no abnormality seen all.Heart rate, blood pressure, electrocardiogram, the fluoroscopy of chest of X line, Abdominal B type ultrasonography inspection etc. are all in normal range (NR) before and after the test, and routine blood test, blood biochemistry index and stool and urine routine inspection result are also at normal range (NR) (seeing table 2).
Data compared
as table 1 test-meal was last
Hematological indices is measured result
before and after table 2 test
2.3, effect property index observing result:
2.3.1, blood lipid peroxide (MDA) content situation before and after the test: see table 3.Test-meal group and control group comparison MDA content do not have significant difference (P＞0.05) before the test; Test-meal group test back does not have significant difference (P＞0.05) with the preceding relatively MDA content of test, does not more also have significant difference (P＞0.05) with control group.
MDA assay result
before and after table 3 test
2.3.2, blood superoxide dismutase (SOD) activity change situation before and after the test:
See table 4.Test-meal group SOD activity and control group relatively do not have significant difference (P＞0.05) before the test, and the test-meal group is tested the back and tested the active significantly rising (P＜0.01) of the preceding SOD of comparison, with significantly rising (P＜0.01) of control group.
Blood SOD determination of activity result
before and after table 4 test
2.3.3, blood glutathione peroxidase (GSH-Px) activity change situation before and after the test:
See table 5.Compare the active no significant difference (P＞0.05) of GSH-Px with control group before the test of test-meal group; Test-meal group test back and the active no marked change (P＞0.05) of the preceding relatively GSH-Px of test more also do not have significant difference (P＞0.05) with control group.
Blood GSH-Px determination of activity result
before and after table 5 test
3, brief summary
Capsule antioxidation human feeding trial result of the present invention shows, no abnormality seens such as duration of test experimenter's spirit, diet, sleep, stool and urine, and health check-up each item safety indexes is no abnormality seen also, shows that the present invention has no adverse effects to human body.
Test-meal group and control group comparison MDA content and GSH-Px activity all do not have significant difference (P＞0.05) before and after the test.Test-meal group test back significantly raises (P＜0.01) with the preceding relatively SOD of test is active, with significantly rising (P＜0.01) of control group.By evaluation criterion, the present invention has anti-oxidation function.
Claims (6)
1. an anti-oxidation health capsule is characterized in that: comprise the capsule that grape seed extract, Tea Polyphenols, shitosan, vitamin E, vitamin C and filler are processed.
2. anti-oxidation health capsule according to claim 1 is characterized in that: said filler is a starch.
3. anti-oxidation health capsule according to claim 2 is characterized in that, said each constituent content is:
Grape seed extract 37.5g
Tea Polyphenols 150g
Shitosan 82.5g
Vitamin E 4.5g
Vitamin C 4g
Starch 21.5g.
4. one kind prepares the method for capsule according to claim 1, it is characterized in that, comprises following steps:
1), claims grape seed extract, Tea Polyphenols, shitosan, vitamin E, vitamin C and starch by formula rate;
2), grape seed extract, Tea Polyphenols and shitosan pulverized 80 mesh sieves, fine powder; Grape seed extract, Tea Polyphenols and shitosan fine powder mix 20 minutes to evenly, get mixed powder A;
3), vitamin E, vitamin C and starch crosses 80 mesh sieves, fine powder; Vitamin E, vitamin C and starch dust mix about 20 minutes to evenly, get mixed powder B;
4), mixed powder A and mixed powder B are mixed to evenly with the equivalent incremental method again, total mixed powder;
5), with total mixed powder filled capsules.
5. preparation method according to claim 4 is characterized in that: in the said step 5), loading amount is the 0.3g/ grain, the bottling of polishing back, and certified products carry out external packing after the quality inspection, the finished product warehouse-in.
6. according to claim 4 or 5 described preparation methods, it is characterized in that:
Step 1)～step 5) is accomplished in 100,000 grades of clean areas.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102674922A CN102379415A (en) | 2010-08-30 | 2010-08-30 | Antioxidant healthcare capsule and preparation method thereof |
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| CN2010102674922A CN102379415A (en) | 2010-08-30 | 2010-08-30 | Antioxidant healthcare capsule and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104473149A (en) * | 2014-11-10 | 2015-04-01 | 浙江大学 | Health food with antioxidant effect |
| CN106075412A (en) * | 2016-07-29 | 2016-11-09 | 陈石良 | A kind of antioxidation SOD compound enzyme capsule and preparation method thereof |
| CN106262883A (en) * | 2016-08-02 | 2017-01-04 | 刘永潇 | A kind of Folium Bambusae soft polyphenol capsule and preparation method thereof |
| CN106360179A (en) * | 2016-08-31 | 2017-02-01 | 宣城柏维力生物工程有限公司 | Electrolyte sports beverage and preparation process thereof |
| CN106387586A (en) * | 2016-08-31 | 2017-02-15 | 宣城柏维力生物工程有限公司 | Whey protein and beta-hydroxy-methyl butyrate sport drink and production technology thereof |
| CN107897888A (en) * | 2017-11-08 | 2018-04-13 | 深圳瑞德源健康科技有限公司 | A kind of jerusalem artichoke capsule and preparation method thereof |
| CN108684884A (en) * | 2018-05-23 | 2018-10-23 | 南京中生生物科技有限公司 | A kind of composition and preparation method thereof of chitosan oligosaccharide, green-tea extract |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104473149A (en) * | 2014-11-10 | 2015-04-01 | 浙江大学 | Health food with antioxidant effect |
| CN106075412A (en) * | 2016-07-29 | 2016-11-09 | 陈石良 | A kind of antioxidation SOD compound enzyme capsule and preparation method thereof |
| CN106262883A (en) * | 2016-08-02 | 2017-01-04 | 刘永潇 | A kind of Folium Bambusae soft polyphenol capsule and preparation method thereof |
| CN106360179A (en) * | 2016-08-31 | 2017-02-01 | 宣城柏维力生物工程有限公司 | Electrolyte sports beverage and preparation process thereof |
| CN106387586A (en) * | 2016-08-31 | 2017-02-15 | 宣城柏维力生物工程有限公司 | Whey protein and beta-hydroxy-methyl butyrate sport drink and production technology thereof |
| CN107897888A (en) * | 2017-11-08 | 2018-04-13 | 深圳瑞德源健康科技有限公司 | A kind of jerusalem artichoke capsule and preparation method thereof |
| CN108684884A (en) * | 2018-05-23 | 2018-10-23 | 南京中生生物科技有限公司 | A kind of composition and preparation method thereof of chitosan oligosaccharide, green-tea extract |
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Application publication date: 20120321 |