JP2008094754A - Nutrient composition for diabetes or blood sugar control - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a nutrient composition for diabetes or blood sugar control, effective for the blood sugar control and complication prevention of a diabetes patient, enabling sufficient nutritional management, and having good flavor. <P>SOLUTION: The nutrient composition for the diabetes or the blood sugar control contains glucides, proteins, lipids, dietary fiber, vitamins and minerals as nutrient components. The composition further contains catechins originated from tea, and L-arabinose and/or an extract of leaves of mulberry. The content of vitamin C per 100 kcal is 30-150 mg, and the content of vitamin E per 100 kcal is 3-10 mg. The ratio by weight of the catechins originated from the tea to the L-arabinose and/or the extract of the leaves of the mulberry is (1:2) to (1:5). The content of the dietary fiber is preferably 5-10 wt.% based on the whole solid components. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a nutritional composition for controlling diabetes or blood glucose level. More specifically, the present invention contains tea-derived catechins, L-arabinose and / or mulberry leaf extract, and specific amounts of vitamin C and vitamin E, in addition to the usual nutritional components. The present invention relates to a nutritional composition for controlling diabetes or blood glucose level capable of preventing diabetes and its complications.

The number of diabetic patients and their reserves in Japan has been increasing year by year with the westernization of meals, and according to a 2002 Ministry of Health, Labor and Welfare survey, there are 16 million people. Diabetes is one of the causative diseases of metabolic syndrome, and its treatment is very important.
For the treatment of diabetes, diet therapy is most important in combination with drug therapy and exercise therapy. Patients should take into account the necessary balance of energy and nutrients while maintaining adequate blood sugar control. However, there are many cases of so-called energy-restricted diets that limit carbohydrates and energy intake in diabetic diets during hospital meals and home treatments, considering ingredients and compositions that are effective for the treatment of diabetes. The fact is that no menu is provided.
The cause may be easy dependence on easy drug therapy, but in hospitals and homes, patients and healthcare professionals in terms of labor and costs for preparing special menus and obtaining materials, etc. There is a heavy burden on

  Furthermore, diabetic patients may suffer from other illnesses and injuries, and thus may not be adequately replenished with necessary energy and nutrients, resulting in poor nutritional status and insufficient treatment of diabetes. For example, for elderly people, it is difficult to have sufficient diet due to decreased appetite or living alone, and when cancer patients have diabetes, appetite decreases due to side effects of anticancer drugs and sufficient diet Often cannot be implemented. Furthermore, when a surgical invasion is applied to a living body, such as a postoperative patient or trauma patient, postoperative hyperglycemia tends to occur due to a decrease in glycolytic enzyme activity. However, due to gastrointestinal dysfunction and loss of appetite, it is often impossible to consume a normal diet.

  When considering the QOL of a diabetic patient, a normal diet is the most natural and desirable form of dietary therapy if possible. However, if oral intake is not possible due to anorexia, etc., but the patient's gastrointestinal function is normal, in principle, enteral nutrition should be selected over parenteral nutrition. Enteral nutrition is useful for reducing medical costs and maintaining gastrointestinal function. In parenteral nutrition, glucose in the preparation is administered directly in a large amount directly into the blood vessels without going through the intestine, which is preferable for diabetics. Because there is no.

  Thus, enteral nutrition is an essential nutritional management method for diabetic patients more than patients with other diseases, and several enteral nutrition products are sold for that purpose. These existing products are slightly different in composition of carbohydrates and lipids from general enteral nutrition products, and have been devised to prevent the rapid increase in blood glucose level. In the diet therapy for diabetic patients, sufficient blood glucose control is an important goal, but on the other hand, prevention of serious complications and suppression of progress in diabetic patients associated with hyperglycemia are also important goals. Of the two goals of this diet therapy, there are no nutritional products that are useful in terms of glycemic control but have the effect of suppressing the glycation reaction of biological protein components, which is a major factor in preventing complications.

  For this reason, providing a diabetic patient with a nutritional composition containing appropriate amounts of both active ingredients for glycemic control and complication prevention is effective in treating diabetes and preventing the progression of symptoms, such as insulin and hypoglycemic drugs. It is believed that drug dosage can be reduced. Therefore, it is desired to provide a product that is such a nutritional composition and that is free of labor and cost.

Patent Document 1 discloses that by using mulberry leaf extract and tea catechin in a ratio of 1: 1 to 1: 5, it is possible to normalize glycemic control in diabetic patients by inhibiting carbohydrate digestive enzyme activity. It is disclosed.
However, when the present inventors examined, the nutritional composition prepared by using the mulberry leaf extract and the tea catechin in this ratio has too much tea-derived catechin amount relative to the mulberry leaf, Absorption of carbohydrates and fats was hindered, making it unsuitable for patient nutritional management.

Patent Document 2 discloses 1-deoxynojirimycin (1 weight ratio), which is an active ingredient in mulberry leaves, and a flavonoid-containing substance (0.025 to 5 weight ratio) obtained from green tea and / or mulberry tea. A food / beverage composition for improving blood glucose is disclosed.
However, when 1-deoxynojirimycin and tea catechin in the mulberry leaf extract were mixed at a weight ratio described in Patent Document 2, a nutritional composition was prepared. Too much, bitterness and astringent taste derived from mulberry leaf extract were strong, and the flavor was extremely inappropriate for oral intake as an enteral nutrient.
JP 2004-105157 A Japanese Patent No. 3530657

  The present invention solves the above-mentioned problems of the prior art, is effective in controlling blood glucose and preventing complications in diabetic patients, can perform sufficient nutritional management, and has good flavor or diabetes control It is an object to provide a nutritional composition.

As a result of intensive studies to solve the above problems, the present inventors have found that, in addition to the main nutrient components, tea-derived catechin, mulberry leaves and / or L-arabinose, specific amounts of vitamin C and vitamin E, The present inventors have found that a nutritional composition containing can control blood glucose and is effective in preventing and progressing complications.
That is, the present invention provides a nutritional composition for diabetes or blood sugar level control containing saccharides, proteins, lipids, dietary fibers, vitamins and minerals as nutritional components, tea-derived catechins, L-arabinose and And / or a mulberry leaf extract, wherein the content of vitamin C per 100 kcal is 30 to 150 mg, and the content of vitamin E per 100 kcal is 3 to 10 mg. .
It contains carbohydrates, proteins, lipids, dietary fibers, vitamins and minerals as nutritional components, and contains tea-derived catechins and L-arabinose and / or mulberry leaf extract. A nutritional composition for controlling diabetes or blood glucose level.
In the present invention, the weight ratio of tea-derived catechins to L-arabinose and / or mulberry leaf extract is 1: 2 to 1: 5, and the content of dietary fiber is 5 per total solid content. The nutritional composition for diabetes or blood glucose level control of 10% by weight or more.
The present invention also provides the nutritional composition for controlling diabetes or blood glucose level, comprising polyphenols as antioxidant components other than tea-derived catechins.
The present invention also provides the diabetes or blood glucose wherein the polyphenol is a grape seed extract, olive leaf extract, guava leaf extract, tomorrow leaf extract, ginkgo biloba extract, rutin or flavonoids derived from citrus or berries. It is a nutritional composition for value control.

  According to the present invention, it is an object to provide a nutritional composition for diabetes or blood glucose control that is effective for blood glucose control and complication prevention in diabetic patients, can perform sufficient nutritional management, and has good flavor. To do.

The present invention will be described in detail below.
The nutritional composition for controlling diabetes or blood glucose level of the present invention contains carbohydrates, proteins, lipids, dietary fibers, vitamins and minerals as nutritional components, and catechins derived from tea as other essential components, It contains L-arabinose and / or mulberry leaf extract and specific amounts of vitamin C and vitamin E.

Among nutrient components, carbohydrates, proteins, and lipids are not particularly limited, and conventional components can be blended in conventional amounts.
As vitamins, it is preferable to contain vitamins A, D, K, B1, B2, B6, B12, folic acid, pantothenic acid, and niacin in addition to vitamin C and vitamin E having an antioxidant action.
Vitamin C is contained in an amount of 30 to 150 mg per 100 kcal of the nutritional composition of the present invention.
Moreover, 5-10 mg of vitamin E is contained per 100 kcal of the nutritional composition of the present invention.
Vitamin C and Vitamin E are nutrients with strong antioxidant properties, and when combined in this amount, an anti-glycation effect is obtained, and a synergistic effect with tea-derived catechins has the effect of preventing diabetic complications. Can be increased.
Incidentally, the amount of vitamin C and vitamin E contained in a commercially available normal nutritional composition is 5 to 25 mg and 0.3 to 3 mg, respectively, per 100 kcal, which is significantly lower than the nutritional composition of the present invention. It has become.
Further, the minerals are not particularly limited, but preferable examples include organic or inorganic salt mixtures such as Na, K, Ca, Mg, P, Cl, Fe, Se, I, Mo, Mn, and Cr. it can.

Dietary fiber has the effect of increasing the viscosity of the gastrointestinal tract contents, slowing down postprandial hyperglycemia in diabetics and impaired glucose tolerance, and contributing to normalization of blood glucose control. Although dietary fiber is not specifically limited, It is preferable to contain 5-10 weight% with respect to the total solid of the nutrition composition of this invention. By setting the blending amount of dietary fiber to 5 to 10% by weight, a rapid increase in blood glucose after meal can be suppressed together with other components.
In the nutritional composition of the present invention, by using dietary fiber and L-arabinose and / or mulberry leaf extract in combination, postprandial hyperglycemia can be efficiently suppressed by different mechanisms of action. .
The dietary fiber is not particularly limited, but agar, cellulose, beet fiber, wheat bran, glucomannan, galactomannan, carrageenan, gum arabic, locust bean gum, pectin, guar gum, guar gum degradation product, alginic acid, sodium alginate, poly Dextrose, indigestible dextrin and the like are preferable examples, and these can be used alone or in combination of two or more.

The nutritional composition for controlling diabetes or blood glucose level of the present invention contains tea-derived catechins.
Examples of tea include, but are not limited to, green tea, oolong tea and black tea. Tea-derived catechins have an excellent effect of preventing complications of diabetes, that is, suppressing glycation reaction of biological proteins.
The tea-derived catechins are not particularly limited. For example, after immersing the dried tea leaf for 15 minutes, and then drying and pulverizing the tea leaf extract obtained by steam blanching (100 ° C., 10 minutes), Those prepared by sterilizing with hot air of 180 ° C. for 3 seconds can be used.

In addition to the tea-derived catechins, other substances having an antioxidative action can be added to the nutritional composition of the present invention.
Examples of other substances having an antioxidative action include polyphenols. As polyphenols, tannin, which is a polymer of tea-derived catechin, guava leaf extract, tomorrow leaf extract, ginkgo biloba extract, rutin, grape seed-derived proanthocyanidins, olive leaf-derived oleuropein, Examples include flavonoids that are abundant in citrus fruits and berries. Examples of other substances having an antioxidative action include carotenoids, histidine-containing dipeptides composed of anserine-carnosine contained in animal extracts, vitamin C, vitamin E, and the like.
When these antioxidant components are used in combination with tea-derived catechins, the effect of suppressing the saccharification reaction can be enhanced by a synergistic effect.

  The content of tea-derived catechins in the nutritional composition of the present invention, or the total content when tea-derived catechins and other antioxidant components are used in combination is 0.1 wt% to 2 wt% per total solid content. % Is preferable. If the content is less than 0.1% by weight, the glycation-inhibiting effect cannot be obtained, and if it exceeds 2% by weight, the flavor of the nutritional composition decreases, and in extreme cases, even the astringent taste is felt. It is not preferable.

The nutritional composition for controlling diabetes or blood glucose level of the present invention contains L-arabinose and / or mulberry leaf extract as an essential component. L-arabinose and / or mulberry leaf extract can suppress a rapid increase in blood glucose after a meal, as with dietary fiber.
L-arabinose is a pentose, suppresses digestion and absorption of sucrose by specifically inhibiting sucrose, and suppresses postprandial hyperglycemia by regulating an increase in blood sugar. As L-arabinose, those manufactured by Unitika Ltd. can be used.
The mulberry leaf extract contains 1-deoxynojirimycin and has α-glucosidase inhibitory activity, so it regulates digestion and absorption of carbohydrates and suppresses postprandial hyperglycemia. The mulberry leaf extract manufactured by Minato Pharmaceutical Co., Ltd. can be used. Alternatively, a mulberry leaf prepared by an extraction method such as a hot water extraction method may be used. Furthermore, mulberry leaves themselves can also be used.
Any one of L-arabinose and / or mulberry leaf extract may be used or a mixture of both may be used.
The blending amount of L-arabinose and / or mulberry leaf extract in the nutritional composition of the present invention is preferably 0.2 wt% to 5.0 wt% per total solid content.

In the nutritional composition for controlling diabetes or blood glucose level of the present invention, the weight ratio of tea-derived catechins to L-arabinose and / or mulberry leaf extract is 1: 2 to 1: 5. preferable.
When the weight ratio of tea-derived catechins and mulberry leaf extract and / or L-arabinose is outside the above range, postprandial hyperglycemia, sugar and lipid absorption is suppressed, and diarrhea occurs. Since the tendency becomes strong, it is not preferable.

By having the composition as described above, the nutritional composition for controlling diabetes or blood glucose level according to the present invention can suppress a rapid increase in blood glucose after meals, suppress glycation reaction of biological proteins, and diabetic complications. It can be prevented and is extremely effective in the nutritional management of diabetics.
In addition, the nutritional composition of the present invention has a good flavor and does not have a bitter or astringent taste.

The form of the nutritional composition of the present invention is not particularly limited, and it is a powder mixture obtained by powder-mixing each active ingredient and each nutritional component, a liquid one obtained by dissolving in water, or a liquid one Preferable examples include gels obtained by mixing gelling agents and powders obtained by drying liquids.
The nutritional composition of the present invention can be produced in any form by a conventional production method. In addition to the components specified above, conventional components can also be contained. For example, emulsifiers such as phospholipids, glycerin fatty acid esters, and sucrose fatty acid esters may be used in the preparation of the liquid nutritional composition as necessary. Moreover, you may use gelling agents, such as agar, pectin, carrageenan, gellan gum, locust bean gum, alginic acid, sodium alginate, for preparation of a gel-like nutritional composition as needed.

The administration form of the nutritional composition of the present invention is not particularly limited, and can be changed depending on the patient's condition and the patient's condition, and can be administered either orally, by tube or enteral.
Further, the nutritional composition for controlling diabetes or blood glucose level of the present invention may be used alone, but may be used in combination with a normal meal, a half meal or an appropriate amount of meal.
In addition, although the nutrition composition for diabetes or blood glucose level control of this invention changes with a patient's symptom, age, etc., it is preferable to take in about 1200 kcal-1800 kcal per day and divide into 1 to several times.

  Hereinafter, the present invention will be described in more detail with reference to examples and test examples. However, these are merely examples and do not limit the scope of the present invention. Note that what is simply described as “%” indicates “% by weight” unless otherwise specified.

(Example 1)
(Manufacture of gel nutrition composition)
With the formulation shown in Table 1, a gel-like nutritional composition was prepared according to a conventional method.
The amount of tea-derived catechin added to the nutritional composition of this example was 1.8% by weight based on the total solid content. The amount of mulberry leaf extract added was 3.7% by weight based on the total solid content. As dietary fiber, indigestible dextrin and agar were used, and the amount added as dietary fiber was 7.3% by weight based on the total solid content. Moreover, the olive leaf extract was used as polyphenols, and the compounding quantity was 0.4 weight% per total solid. Vitamin C and E were 50 mg and 5 mg per 100 kcal, respectively. Minerals are organic or inorganic salt mixtures of Na, K, Ca, Mg, P, Cl, Fe, Se, I, Mo, Mn and Cr. Vitamins other than vitamins C and E are vitamins A, D, K , B1, B2, B6, B12, a mixture of folic acid, pantothenic acid, and niacin were blended so as to meet the Japanese dietary intake standards.

(Example 2)
(Preparation of liquid nutritional composition)
With the formulation shown in Table 2, a liquid nutritional composition was prepared according to a conventional method.
The amount of tea-derived catechins added to the nutritional composition of this example was 1.2% by weight based on the total solid content. The amount of mulberry leaf extract added was 2.4% by weight based on the total solid content. Indigestible dextrin and agar were used as dietary fiber, and the amount added as dietary fiber was 8.6% by weight based on the total solid content. Moreover, the grape seed extract was used as polyphenol, and the compounding quantity was 0.4 weight% per total solid. Vitamin C and E were 100 mg and 7 mg per 100 kcal, respectively. Minerals are organic or inorganic salt mixtures of Na, K, Ca, Mg, P, Cl, Fe, Se, I, Mo, Mn and Cr. Vitamins other than vitamins C and E are vitamins A, D, K , B1, B2, B6, B12, a mixture of folic acid, pantothenic acid, and niacin were blended so as to meet the Japanese dietary intake standards.

(Test Example 1)
(Effect on blood glucose level in healthy rats)
Using the nutritional compositions A to E having the formulations shown in Table 3, the effect on the blood glucose level of healthy rats was examined. About the compounding quantity of each compounding component of nutrition composition AE, it shows in Table 4.
A 5-week-old Sprague-Dawley male rat (manufactured by Claire Japan) was preliminarily raised on a CE2 feed (manufactured by Claire Japan) for 1 week, and then subjected to this test at 6 weeks of age. After the rats were fasted for 18 hours, the blood glucose level in the tail vein of each individual was measured, and the nutritional composition A administration group, the B administration group shown in Table 3, The C administration group and the comparative control group were divided into a total of 5 groups: a nutrition composition D administration group and a nutrition composition E administration. The number of individuals in each group was 10. The comparison between each group was made by the Tukey-Kramer test method, and P <0.05 was considered significant.
For each group, the nutritional compositions A to E shown in Table 3 were forcibly orally administered using a stomach sonde for rats so as to be 10.0 kcal per kg body weight. Before administration (0 minutes), 30 minutes, 60 minutes, 90 minutes, and 120 minutes after administration, the blood glucose level of tail vein blood was measured with a small colorimetric blood glucose meter (Medisafe Reader: Terumo). The results are shown in FIG.
In FIG. 1, when the blood glucose level transition of each group is compared, the nutrient composition D increased to about 149 mg / dL after 30 minutes, whereas the blood glucose levels of the nutrition composition A, B, C, and E administration groups were respectively It was significantly suppressed to 124 mg / dL, 121 mg / dL, 115 mg / dL, and about 119 mg / dL.
Moreover, the blood glucose level transition of the nutrition composition E administration group which mix | blended L-arabinose and dietary fiber excessively was substantially the same as that of the nutrition composition A, B, and C groups. From these results, it was found that the nutritional compositions A, B, and C containing the nutritional components based on the present invention are effective in suppressing postprandial hyperglycemia.

(Test Example 2)
(Effect on blood glucose level of streptozotocin-induced type 1 diabetic rats)
Using the blended nutritional composition shown in Table 3, the effect on blood glucose levels of streptozotocin-induced type 1 diabetes model rats was examined. It shows in Table 4 about each nutrient component compounding quantity of each nutrition composition A, B, C, D, and E used for the test.
A 5-week-old Sprague-Dawley male rat (manufactured by Claire Japan) was preliminarily raised on a CE2 feed (manufactured by Claire Japan) for 1 week, and then subjected to this test at 6 weeks of age. Streptozotocin (hereinafter referred to as STZ) -induced type 1 diabetes model rats were prepared by dissolving STZ (manufactured by Wako Pure Chemical Industries, Ltd.) in a citrate buffer solution (pH 4.5, 0.05 M) to a concentration of 14 mg / mL, and immediately 5 mL / kg was prepared by injection into the abdominal cavity of rats. After injection of STZ, CE2 (manufactured by CLEA Japan) and water were ingested and bred for 1 week. Thereafter, the rats were fasted for 18 hours, the blood glucose level in the tail vein of each individual was measured, and the nutritional composition A administration group and B administration shown in Table 3 were made so that the average blood glucose level was the same among the groups. The group, C administration group and comparative control group were divided into a total of 5 groups: nutrition composition D administration group and single-use nutrition composition E administration. The number of individuals in each group was 10. The comparison between each group was made by the Tukey-Kramer test method, and P <0.05 was considered significant.
For each group, the nutritional composition A, B, C, D or E shown in Table 3 was orally administered by gavage using a gastric sonde for rats so as to be 10.0 kcal per kg body weight. A small colorimetric blood glucose meter (Medisafe Leader: manufactured by Terumo Corporation) before administration (0 minutes), 30 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, and 180 minutes after administration. ). The results are shown in FIG.

  In FIG. 2, when the blood glucose level transition after intake of each nutritional composition is compared, the nutritional composition D increased to about 328 mg / dL after 30 minutes, whereas the nutritional composition A, B, C, and E administration groups The blood glucose levels were significantly suppressed to about 289 mg / dL, 274 mg / dL, 288 mg / dL and 289 mg / dL, respectively. Moreover, the blood glucose level transition of the nutrition composition E administration group which mix | blended L-arabinose and dietary fiber excessively was substantially the same as that of the nutrition composition A, B, and C groups. From these results, it was found that the nutritional compositions A, B, and C containing the nutritional components based on the present invention are effective in suppressing postprandial hyperglycemia.

(Test Example 3)
(Effect on blood glucose level of spontaneous type 2 diabetic rats (GK rats))
Using the blended nutritional composition shown in Table 3, the effect on the blood glucose level of GK rats was examined. Table 4 shows the amount of each nutritional component of each nutritional composition A, B, C, D, E used in the test.
5-week-old GK male rats (manufactured by Claire Japan) were preliminarily raised on CE2 feed (manufactured by Claire Japan) for 1 week and then subjected to the test at 6 weeks of age. After the rats were fasted for 18 hours, the blood glucose level in the tail vein of each individual was measured, and the nutritional composition A administration group, the B administration group shown in Table 3, The C administration group and the comparative control group were divided into a total of 5 groups: a nutrition composition D administration group and a single use nutrition composition E administration. The number of individuals in each group was 10. The comparison between each group was made by the Tukey-Kramer test method, and P <0.05 was considered significant.
For each group, the nutritional composition A, B, C, D or E shown in Table 3 was orally administered by gavage using a gastric sonde for rats so as to be 10.0 kcal per kg body weight. A small colorimetric blood glucose meter (Medisafe Leader: manufactured by Terumo Corporation) before administration (0 minutes), 30 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, and 180 minutes after administration. ). Furthermore, each nutritional composition was freely ingested for 5 weeks, and the growth amount, intake amount and intake energy amount were measured. The results are shown in FIG. 3, FIG. 4, and FIG.

In FIG. 3, when the blood glucose level transition after intake of each nutritional composition is compared, the nutritional composition D increased to about 180 mg / dL after 30 minutes, whereas the nutritional composition A, B, C and E administration groups The blood glucose levels were about 169 mg / dL, 160 mg / dL, 159 mg / dL, and 162 mg / dL, respectively. Moreover, the blood glucose level transition of the nutrition composition E administration group which mix | blended L-arabinose and dietary fiber excessively was substantially the same as that of the nutrition composition A, B, and C groups. From these results, it was suggested that the nutritional compositions A, B, and C containing the nutritional components based on the present invention are effective in suppressing postprandial hyperglycemia.
In addition, the amount of growth and intake when the respective nutritional compositions shown in FIGS. 4 and 5 were freely ingested for 5 weeks were significantly reduced in the nutritional composition E group containing a large amount of catechins. As a result. Catechin is known to exhibit astringency and astringency when the amount is excessive. Therefore, it was thought that the amount of intake in the nutrition composition E group may have decreased. From this result, it was found that the nutritional composition E is not suitable for nutritional management by free intake.

(Test Example 4)
(Effect on blood glucose level and HbA1c when used as a supplement in clinical human studies)
Using the nutritional composition shown in Table 5, healthy adult men and women were recruited. The nutritional composition C is designed according to the present invention, the nutritional composition F is Inslow (manufactured by Meiji Dairies), which is a nutritional composition for diabetics, and the nutritional composition G uses a nutritional composition for general people did. In accordance with the spirit of the Declaration of Helsinki, explain the purpose of the test, test method, expected results, participation will not be detrimental, explain the matters related to privacy protection, and fully understand and agree Healthy adults who voluntarily submitted a certificate and whose fasting blood glucose level was within the reference value (70 mg / dL or more and less than 120 mg / dL) were employed as subjects (single intake test: 36 people, average age 45. 3 ± 11.3 years). In the long-term study, adults with a fasting blood glucose level of 120 mg / dL or more and less than 150 mg / dL who voluntarily submitted a consent form were adopted as subjects (long-term continuous intake test: 15 subjects) , Average 39. ± 9.5 years).
In the single intake test, fasting was conducted after 21:00 on the day before the test, and 36 subjects (18 males and 18 females) were randomly divided into 3 groups of C, F, and G groups, with 12 persons per group. After receiving a doctor's inquiry on the morning of the test day, blood was collected in an empty stomach, and then the stress test was started within 1 hour. The test subjects were fed 50 g of loaded food onigiri (energy: about 80 kcal) with the nutritional composition within 15 minutes, blood was collected again at 30, 60, 90, and 120 minutes after the meal, and the blood glucose level was measured. All measured values were expressed as mean ± standard deviation, and comparison between groups was performed by Tukey-Kramer test method, and P <0.05 was considered significant. The results are shown in FIG.
In FIG. 6, when the blood glucose level transition after intake of each nutritional composition was compared, the nutritional compositions F and G rose to about 180 mg / dL and 186 mg / dL after 30 minutes, whereas the nutritional composition C administration group The blood glucose level was about 164 mg / dL. From this result, the nutritional composition C containing the nutritional component based on the present invention is significantly higher in postprandial hyperglycemia than the nutritional composition F for the diabetic and the nutritional composition G for the general population, even when ingested with a normal diet. It was found to suppress.

In the long-term intake test, 15 (8 males, 7 females) subjects took the nutritional composition C three times a day for 12 weeks with meals. Blood samples were collected before the start of intake (0 week), 4 weeks, 8 weeks, 12 weeks, 16 weeks and weeks, and fasting blood glucose levels and hemoglobin A1c (hereinafter referred to as HbA1c), which are indicators of diabetic conditions, were measured. All measured values were expressed as mean ± standard deviation. The respective results are shown in FIGS.
In FIG. 7, when the blood glucose level transition after ingestion of the nutritional composition is compared, the nutritional composition C shows a low value in the fourth, eighth, twelfth, sixteenth, and twentyth week from the 0th week of ingestion, and 20 In the week, the fasting blood glucose level was about 110 mg / dL, which is a normal value. Moreover, the HbA1c value in FIG. 8 also showed a low value at 4, 8, 12, 16, and 20 weeks from the 0th week of ingestion. HbA1c is obtained by binding glucose to hemoglobin contained in erythrocytes and is an index of glycation. From these results, it can be seen that the nutritional composition C containing the nutritional component based on the present invention is beneficial for normalization of fasting blood glucose and prevention of glycation by continuing to take, and prevents diabetes and complications. It was.

  The nutritional composition for diabetes or blood sugar level control of the present invention is effective for blood sugar control and prevention of complications, is capable of sufficient nutrition management, is good in flavor, and is useful as a nutritional composition for diabetic patients It is.

It is a graph which shows the influence which acts on the blood glucose level of a healthy rat. It is a graph which shows the influence which acts on the blood glucose level of streptozotocin induction type 1 diabetes. It is a graph which shows the influence which acts on the blood glucose level in a GK rat. It is a graph which shows the influence which acts on the growth amount in a GK rat. It is a graph which shows the influence which it has on the intake energy amount in a GK rat. It is a graph which shows the influence which acts on the blood glucose level after ingestion of a normal diet and each nutrition composition. It is a graph which shows the change of the fasting blood glucose by the long-term feeding of the nutrition composition C. It is a graph which shows the change of blood HbAlc by the long-term feeding of the nutrition composition C.

Claims (4)

In a nutritional composition for diabetes or blood sugar level control containing carbohydrates, proteins, lipids, dietary fibers, vitamins and minerals as nutritional components, catechins derived from tea, and L-arabinose and / or mulberry leaf extract A nutritional composition for controlling diabetes or blood glucose level, wherein the content of vitamin C per 100 kcal is 30 to 150 mg and the content of vitamin E per 100 kcal is 3 to 10 mg. The weight ratio of tea-derived catechins to L-arabinose and / or mulberry leaf extract is 1: 2 to 1: 5, and the content of dietary fiber is 5 to 10% by weight based on the total solid content The nutrition composition for diabetes or blood glucose level control according to claim 1. 3. The nutritional composition for diabetes or blood glucose level control according to claim 1 or 2, comprising polyphenols as antioxidant components other than tea-derived catechins. The diabetes or blood glucose level according to claim 3, wherein the polyphenol is a grape seed extract, olive leaf extract, guava leaf extract, tomorrow leaf extract, ginkgo biloba extract, rutin or flavonoids derived from citrus or berries. Nutritional composition for control.

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