CN108497498A - A kind of functional food of relieving alcoholism and protecting liver and preparation method thereof - Google Patents
A kind of functional food of relieving alcoholism and protecting liver and preparation method thereof Download PDFInfo
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- CN108497498A CN108497498A CN201810507238.1A CN201810507238A CN108497498A CN 108497498 A CN108497498 A CN 108497498A CN 201810507238 A CN201810507238 A CN 201810507238A CN 108497498 A CN108497498 A CN 108497498A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention provides a kind of functional food of relieving alcoholism and protecting liver, in terms of mass parts, is made by the raw material including following components：5~20 parts of 20~40 parts of raisin tree seed extract, 20~40 parts of kudzu root extract, 5~30 parts of Honegsukle flower P.E, 5~30 parts of green-tea extract and licorice.The functional food of the present invention is by combining the raisin tree seed extract of specific proportioning, kudzu root extract, Honegsukle flower P.E, green-tea extract and licorice; synergistic effect is played each other; obtain the functional food with relieving alcoholism and protecting liver effect; its is nontoxic; hepatic tissue ADH activity can be improved; promote alcohol metabolism; reduce concentration of ethanol in serum; the supersession rate of accelerating alcohol metabolism product; mitigate the damage of tissue and cell, play the promoting wakening that relieves the effect of alcohol, protects liver; the dependence and use to drug are reduced, to reduce the toxic side effect of drug.
Description
Technical field
The present invention relates to field of functional food, more particularly, to the functional food and its system of a kind of relieving alcoholism and protecting liver
Preparation Method.
Background technology
Characters of Chinese Alcoholic Drink Culture is of long standing and well established, and spirits culture is Chinese nation's cooking culture-a important component.A small amount of drink
Wine body health benefits, energy degrading the channel, arteries and veins of invigorating blood circulation, solution is tired, beneficial to body；More drinks then can " drunk ", " middle wine poison ", it is modern
Medicine is known as alcoholism, extremely harmful to body.
On the one hand, alcohol can generate stimulation to gastric mucosa, cause gastric ulcer threat to life；On the other hand, heavy drinking is also
It can influence pregnant woman's development of fetus and mankind spermatozoon forms even cerebral cortical atrophy, be easy to injure with paripheral zone to itself.Also
Have, long-term alcohol is easy to generate dependence to alcohol, prodigious injury can be caused to each organ of body, especially to the damage of liver
Evil, easily causes alcoholic liver injury.Alcoholic liver injury (alcoholic liver disease, ALD) is because taking in alcohol
Excessively cause ethyl alcohol (alcohol) in liver and acetaldehyde to be sharply increased, liver cell is finally made to repeated steatosis, bad
A kind of dead alcoholic liver disease.There is data to show that U.S.'s alcoholic liver disease death occupies the tenth, China is in recent years caused by alcohol
Hepatic lesion also be in ascendant trend, alcohol have become the Etiological for leading to hepatic lesion after virus hepatitis year by year.Alcoholic
The diverse clinical manifestations of hepatic injury, symptom is various, such as weak, loss of appetite, nausea and vomiting and weight loss, can also have serious
Symptom such as hepatic encephalopathy, renal failure and massive bleeding from upper digestive tract etc..
Currently, disintoxicating product mostly be the ingredients such as excitant, vitamin and amino acid, can rapidly play relieve the effect of alcohol, work of sobering up
With, but most chemicals relieving mechanism is to be only capable of that alcohol is promoted to decompose, and plays temporary mitigation, it is difficult to rise
To liver protection effect.
Functional food refer to have trophic function, sensory function and adjust physiological activity function food, including：Enhancing
The food of human body constitution (enhancing immunocompetence, activation lymphatic system etc.)；Prevent disease (hypertension, diabetes, coronary heart disease, just
Secret and tumour etc.) food；It gets well the food of (control cholesterol prevents platelet aggregation, adjusts hematopoiesis function etc.)；It adjusts
Save the food of the food and anti-aging of body rhythms (nerve center, nerve ending, intake and absorption function etc.).Functionality food
The research and development of product still belong to new branch of science and field in China, are the products of multidisciplinary, multi-field continuous mixing together, are related to
Nutrition, pharmacy, physiology, preventive medicine, bioengineering, Food Science.
Therefore, the functional food for developing safely and effectively relieving alcoholism and protecting liver is very urgent, is not only in that relieving alcoholism and protecting liver, also exists
In damage of the prevention alcohol to human body comprehensively.
Invention content
In view of the problems of the existing technology, the present invention provides functional food and its preparation side of a kind of relieving alcoholism and protecting liver
Method, functional food of the invention can promote alcohol metabolism, mitigate damage of the alcohol to tissue and cell, and protect liver
It is dirty.
The present invention provides a kind of functional food of relieving alcoholism and protecting liver, in terms of mass parts, by the raw material system for including following components
：20~40 parts of raisin tree seed extract, 20~40 parts of kudzu root extract, 5~30 parts of Honegsukle flower P.E, green-tea extract 5~
30 parts and 5~20 parts of licorice.
In above-mentioned technical proposal, by by the raisin tree seed extract of specific proportioning, kudzu root extract, Honegsukle flower P.E,
Green-tea extract and licorice combination, play synergistic effect each other, obtain the functional food with relieving alcoholism and protecting liver effect
Product, it is nontoxic, hepatic tissue ADH activity can be improved, promotes alcohol metabolism, reduces concentration of ethanol in serum, accelerating alcohol metabolism
The supersession rate of product mitigates the damage of tissue and cell, plays the promoting wakening that relieves the effect of alcohol, and protects liver.
Preferably, the functional food of the relieving alcoholism and protecting liver is made in terms of mass parts by the raw material including following components：
30~40 parts of raisin tree seed extract, 20~30 parts of kudzu root extract, 10~15 parts of Honegsukle flower P.E, green-tea extract 10~20
10~15 parts of part and licorice.
As a kind of preferred embodiment of the present invention, the functional food is in terms of mass parts, by including following
The raw material of component is made：40 parts of raisin tree seed extract, 20 parts of kudzu root extract, 15 parts of Honegsukle flower P.E, green-tea extract 15
10 parts of part and licorice.
Preferably, the raw material is by raisin tree seed extract, kudzu root extract, Honegsukle flower P.E, green-tea extract and sweet
Careless extract composition.
Preferably, the dosage form of the functional food is capsule, tablet or electuary.
These three above dosage form stabilities of selection are good, and manufacturing cost is relatively low, take with it is easy to carry.Capsule is oral
Afterwards in the disintegration time of gastrointestinal tract than very fast, general 5~10 minutes, GI irritation was small, it is not easy to generate damage to gastric mucosa；
Tablet active constituent is high, and bioavilability is high；It can quickly be dissolved and absorbed after granule is oral, it is in good taste, it is suitble to different crowd.
The present invention also provides a kind of preparation methods of above-mentioned functional food, including：Each component is mixed according to the ratio,
Drying, sterilizing crush and cross 60~100 mesh sieve, and target formulation finally is made in sieving gained fine powder.
Above-mentioned preparation method is simple for process, and will be preferably minimized on the influence of the active constituent of each raw material component, makes obtained
Product efficacy is best.
Preferably, water content is 10wt%~20wt% before each component is mixed.
Preferably, each component mixed, dry after water content be 4wt%~7wt%.
Within the above range by water content control, ensure that mobility of particle is good, convenient for tabletting, filling capsule or packing particle
When Weight control, loading amount error is small.
Preferably, the drying and described sterilize in microwave frequency are 2.45GHz ± 25MHz, and temperature is 60~80 DEG C of items
It is carried out under part.It can achieve the effect that preferably to dry and sterilize in this way, and ensure that product efficacy is unaffected.
Preferably, the sieving was 80 mesh sieve.
The functional food of the present invention is by extracting the raisin tree seed extract, kudzu root extract, honeysuckle of specific proportioning
Object, green-tea extract and licorice combination, play synergistic effect, obtain the functionality with relieving alcoholism and protecting liver effect each other
Food, it is nontoxic, hepatic tissue ADH activity can be improved, promotes alcohol metabolism, reduces concentration of ethanol in serum, accelerating alcohol generation
It thanks to the supersession rate of product, mitigates the damage of tissue and cell, play the promoting wakening that relieves the effect of alcohol, protect liver, reduce to drug
It relies on and uses, to reduce the toxic side effect of drug.
Specific implementation mode
With reference to specific embodiment, the specific implementation mode of the present invention is described in further detail.Following embodiment
For illustrating the present invention, but it is not limited to the scope of the present invention.
Embodiment 1
The present embodiment provides a kind of functional foods of relieving alcoholism and protecting liver to be made by following components in terms of mass parts：Hoveniae semoveniae semen
10 parts of 40 parts of extract, 20 parts of kudzu root extract, 15 parts of Honegsukle flower P.E, 15 parts of green-tea extract and licorice.Institute
It is powder raw material to state five kinds of raw materials, and purchase is from Xi'an day Biotechnology Ltd., similarly hereinafter.
The present embodiment also provides the preparation method of the functional food of above-mentioned relieving alcoholism and protecting liver, including：(Q/ will first be complied with standard
It is quality standard in WHF 0013S-2012, the same below) raisin tree seed extract, kudzu root extract, Honegsukle flower P.E, green tea carries
Take object and licorice by said ratio put into blender in, stir evenly, and control raw material moisture content be 10wt%~
20wt%；The material mixed is uniformly laid in microwave dryer by the thickness of 2~2.5cm again, 60~80 DEG C of temperature,
It is sterilized and is dried under the conditions of 4~10min of time, moisture is less than 7wt% after drying；It then, will be after drying and sterilizing
Material crush, cross 80 mesh sieve to obtain fine powder；Finally, it requires fine powder capsule is made according to functions of the state food technology,
Or tablet or electuary, it is packed.
Embodiment 2
The present embodiment provides a kind of functional foods of relieving alcoholism and protecting liver to be made by following components in terms of mass parts：Hoveniae semoveniae semen
10 parts of 30 parts of extract, 30 parts of kudzu root extract, 10 parts of Honegsukle flower P.E, 20 parts of green-tea extract and licorice.Its
The preparation method is the same as that of Example 1.
Embodiment 3
The present embodiment provides a kind of functional foods of relieving alcoholism and protecting liver to be made by following components in terms of mass parts：Hoveniae semoveniae semen
10 parts of 35 parts of extract, 25 parts of kudzu root extract, 10 parts of Honegsukle flower P.E, 20 parts of green-tea extract and licorice.Its
The preparation method is the same as that of Example 1.
Embodiment 4
The present embodiment provides a kind of functional foods of relieving alcoholism and protecting liver to be made by following components in terms of mass parts：Hoveniae semoveniae semen
10 parts of 25 parts of extract, 35 parts of kudzu root extract, 10 parts of Honegsukle flower P.E, 20 parts of green-tea extract and licorice.Its
The preparation method is the same as that of Example 1.
Embodiment 5
The present embodiment provides a kind of functional foods of relieving alcoholism and protecting liver to be made by following components in terms of mass parts：Hoveniae semoveniae semen
10 parts of 25 parts of extract, 25 parts of kudzu root extract, 20 parts of Honegsukle flower P.E, 20 parts of green-tea extract and licorice.Its
The preparation method is the same as that of Example 1.
Embodiment 6
The present embodiment provides a kind of functional foods of relieving alcoholism and protecting liver to be made by following components in terms of mass parts：Hoveniae semoveniae semen
20 parts of 25 parts of extract, 25 parts of kudzu root extract, 10 parts of Honegsukle flower P.E, 20 parts of green-tea extract and licorice.Its
The preparation method is the same as that of Example 1.
Comparative example 1
A kind of functional food of this comparative example offer is made in terms of mass parts by following components：Raisin tree seed extract 15
Part, 15 parts of kudzu root extract, 35 parts of Honegsukle flower P.E, 10 parts of green-tea extract and 25 parts of licorice.Preparation method
With embodiment 1.
Comparative example 2
A kind of functional food of this comparative example offer is made in terms of mass parts by following components：Raisin tree seed extract 60
Part, 10 parts of kudzu root extract, 10 parts of Honegsukle flower P.E, 10 parts of green-tea extract and 10 parts of licorice.Preparation method
With embodiment 1.
Comparative example 3
A kind of functional food of this comparative example offer is made in terms of mass parts by following components：Raisin tree seed extract 45
Part, 35 parts of kudzu root extract, 5 parts of Honegsukle flower P.E, 10 parts of green-tea extract and 5 parts of licorice.Preparation method is same
Embodiment 1.
Test example
Toxotest
Oral toxicity experiment, binomial mutagenicity test (mouse have been carried out to the functional food of the embodiment of the present invention 1~6
Polychromatic erythrocyte number micronucleus test and sperm malformation test) and 30 days feeding trials safety evaluatio experiment and disease
Tissue examination and gross anatomy experiment are managed, test data does not find that given the test agent has apparent toxic effect, by acute toxicity
Grade scale is evaluated, which belongs to nontoxic grade.
Functional experiment is tested
Efficacy test is carried out to the functional food of the embodiment of the present invention 1 and comparative example 1~3 respectively, including to drunk latent
Fu Qi, the influence in incubation period, drunk rate and the death rate, the influence to equilibrium sensation after acute alcoholism, in acute alcohol
The influence of glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminease (AST) content after poison.
1 materials and methods
1.1 drugs and reagent
Test sample：The functional food of the embodiment of the present invention 1 is provided by Kazakhstan Foucault skill (Wuhan) Group Co., Ltd, rule
Lattice 0.5g/ pieces, human body recommended amounts 50mg/kg*d；The functional food of comparative example 1~3, specification 0.5g/ pieces.
Positive drug：Hai Wangjin cups (the strong word (2002) the 0396th of health, lot number：20160921, Shenzhen sea Wang Jiankang are sent out
Open up Co., Ltd's production)；Or Bifendate (Chinese medicines quasi-word H44023176, lot number：20160907, Guangzhou group of stars share has
Limit company produces).
Reagent：(Bioengineering Research Institute's production, lot number are built up in Nanjing to GPT kits：20160429)；GOT kits (south
Bioengineering Research Institute's production, lot number are built up in capital：20160429)；(bio-engineering research is built up in Nanjing to Coomassie brilliant blue kit
It is produced, lot number：20160429)；Strong, colourless liquor distilled from sorghum (Beijing star Wine Co., Ltd, lot number：20170909).
1.2 experimental animal
Kunming mice, male and female dual-purpose, weight 18-25g are provided by Hubei Province's animal experimental center.
1.3 key instruments and equipment
HH-6 digital displays thermostat water bath (Medical Instruments factory of Jintan City)；Ultraviolet-visible luminosity device (the general analysis general instrument in Beijing
Device Co., Ltd, model：The T6 new centuries)；EL204 electronic analytical balances (plum Teller-support benefit instrument (Shanghai) limited public affairs
Department, model：JB/T 5374-1991)；Electrometer treasure (Jin Li electronic scales Co., Ltd of Zhongshan city, model：ACS-LT)；
XZC-4B types tired instrument of transfer rod formula (medicine section of Shandong Province academy of sciences's equipment station).
2 experimental methods and result
The influence in 2.1 pairs of drunk incubation periods, incubation period, drunk rate and the death rate
80 mouse are taken to be randomly divided into 8 groups：High dose group, middle dose group, low dose group, positive drug group, model group (56
Degree), 1 group of comparative example, 3 groups of 2 groups of comparative example and comparative example, every group 10.Each group mouse elder generation fasting 12h, model group according to
The dosage gavage physiological saline of 0.2mL/10g；Positive drug group according to a concentration of 1.0g/mL of dosage gavage of 0.2mL/10g sea
Wang Jin cup solution；High dose group, middle dose group and low dose group give respectively embodiment 1 functional food 2.0g/kg,
1.0g/kg, 0.5g/kg gavage；1 group of comparative example is according to the functional food in 2.0g/kg dosage gavages comparative example 1；Comparative example 2
Group is according to the functional food in 2.0g/kg dosage gavages comparative example 2；3 groups of comparative example is according to 2.0g/kg dosage gavage comparative examples
Functional food in 3.56 degree of Erguotou wine 0.2mL/10g of the equal gavage of each group mouse after 30min, record mice drunk are latent
Phase, duration, in 6h mice drunk rate and for 24 hours in mouse death rate, data withIt indicates, is made using SPSS130 softwares
Statistical procedures the results are shown in Table 1.
Influence of 1 functional food of table to drunk incubation period, duration, rate of sobering up and the death rate
Compared with model group：*Indicate P<0.05,**Indicate P<0.01.
As shown in Table 1, functional food provided by the invention can be obviously prolonged the drunk latent of acute alcoholism mice
Phase shortens the duration, and the functional food of high dose can significantly reduce the death rate of acute alcoholism mice, with positive drug
Group is similar.
The influence of equilibrium sensation after 2.2 pairs of acute alcoholisms
The basic principle of rotating rods method：Animal keeps one's balance and will not fall on the stick of rotation, needs to rotation
The opposite direction of stick moves, so limb muscle is needed to carry out Coordinating Activity.It is moved with animal muscle after a large amount of central depressants
Weaken, the time that animal falls from stick can be shortened.This law can be used to measure the inhibiting effect of drug Central nervous.
By being randomly divided into 8 groups by the mouse not fallen from transfer rod in pre-selection 3min, (animal packet and administration are same
2.1).Each group mouse is according to 56 degree of Erguotou wines of 0.2mL/20g dosage gavage after 30min, respectively at gavage after drinking 20min,
Animal is put into 16 turns/min tired instrument of transfer rod formula when 90min, 120min, per room one, is recorded in 3min not from transfer rod
It falls number of mice, as shown in table 2.Each group of data sees whether that data are by the inspection of card side with significant difference compared with model group
It tests and is handled.
The influence that 2 functional food of table balances acute alcoholism mice
Compared with model group：*Indicate P<0.05,**Indicate P<0.01.
As shown in Table 2, functional food provided by the invention make mouse after to alcohol each period (3 points on transfer rod
Clock) quantity of not falling is significantly increased, and result is more excellent than positive drug group, illustrates that it soon plays to relieve the effect of alcohol and promotees awake effect.
The influence of 2.3 pairs of acute alcoholism mice glutamic-pyruvic transaminase (ALT) and glutamic-oxalacetic transaminease (AST) content
Animal packet and processing：80 mouse, half male and half female is randomly divided into 8 groups, every group 10, i.e. model group (physiology
Brine group, 0.9%), positive drug group (Bifendate group, 0.2g/kg), the low dose group of 1 functional food of embodiment
(0.5g/kg), middle dose group (1.0g/kg) and high dose group (2.0g/kg), comparative example 1 group (2.0g/kg), 2 groups of comparative example
(2.0g/kg) and comparative example 3 groups (2.0g/kg).The equal gastric infusion of each group, 1 time/d, continuous 10d, gavage volume is 0.2mL/
After 10g, daily gastric infusion 30min, 56 degree of strong, colourless liquor distilled from sorghum white wine 0.16mL/10g of the equal gavage of each group mouse are prohibited on the 10th day after drinking
Food can't help water, weigh afterwards for 24 hours, acquires liver specimens, makees coherent detection.
Specific experimental method is as follows：
(1) it cuts open and kills the previous day disconnected feeding, mouse takes disconnected cervical vertebra execution immediately after blood, cuts open the belly and takes liver, is rushed with 4 DEG C of physiological saline
It washes, filter paper blots, and weighs；
(2) ALT, AST are by kit specification colorimetric method for determining；
(3) data use variance analysis, t inspections to carry out analysis comparison, the results are shown in Table 3.
3 functional food of table influences the content of acute alcoholism mice ALT and AST
Compared with model group：*Indicate P<0.05,**Indicate P<0.01.
As shown in Table 3, functional food of the invention can effectively reduce the raising of ALT and AST, to the liver of drunk mouse
With protective effect.
In conclusion a kind of functional food of relieving alcoholism and protecting liver of the present invention can reduce drunk rate, postpone the drunk time, contracts
It is short to sober up the time, the death rate is reduced, ALT and AST raisings are inhibited, there is significant rush of relieving the effect of alcohol to wake up and liver-protective effect.
Finally, method of the invention is only preferable embodiment, is not intended to limit the scope of the present invention.It is all
Within the spirit and principles in the present invention, any modification, equivalent replacement, improvement and so on should be included in the protection of the present invention
Within the scope of.
Claims (10)
1. a kind of functional food of relieving alcoholism and protecting liver, which is characterized in that in terms of mass parts, by the raw material system for including following components
：20~40 parts of raisin tree seed extract, 20~40 parts of kudzu root extract, 5~30 parts of Honegsukle flower P.E, green-tea extract 5~
30 parts and 5~20 parts of licorice.
2. functional food according to claim 1, which is characterized in that in terms of mass parts, by the original including following components
Material is made：30~40 parts of raisin tree seed extract, 20~30 parts of kudzu root extract, 10~15 parts of Honegsukle flower P.E, green tea extraction
10~15 parts of 10~20 parts of object and licorice.
3. functional food according to claim 2, which is characterized in that in terms of mass parts, by the original including following components
Material is made：40 parts of raisin tree seed extract, 20 parts of kudzu root extract, 15 parts of Honegsukle flower P.E, 15 parts of green-tea extract and Radix Glycyrrhizae
10 parts of extract.
4. according to claims 1 to 3 any one of them functional food, which is characterized in that the raw material is extracted by hoveniae semoveniae semen
Object, kudzu root extract, Honegsukle flower P.E, green-tea extract and licorice composition.
5. according to Claims 1 to 4 any one of them functional food, which is characterized in that the dosage form of the functional food
For capsule, tablet or electuary.
6. the preparation method of Claims 1 to 5 any one of them functional food, which is characterized in that including：Each component is pressed
Proportioning is mixed, is dried, is sterilized, crushed and is crossed 60~100 mesh sieve, and target formulation finally is made in sieving gained fine powder.
7. preparation method according to claim 6, which is characterized in that water content is before each component is mixed
10wt%~20wt%.
8. preparation method according to claim 6, which is characterized in that each component mixed, dry after water content
For 4wt%~7wt%.
9. preparation method according to claim 6, which is characterized in that the drying and the sterilizing are in microwave frequency
2.45GHz ± 25MHz, temperature carry out under the conditions of being 60~80 DEG C.
10. preparation method according to claim 6, which is characterized in that the sieving was 80 mesh sieve.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109045273A (en) * | 2018-11-09 | 2018-12-21 | 何蓉蓉 | A kind of Chinese medicinal alcoholism-relieving composition and preparation method thereof |
| CN109432386A (en) * | 2018-11-08 | 2019-03-08 | 武汉森澜生物科技有限公司 | A kind of corn peptide combinations of relieving alcoholism and protecting liver and preparation method thereof |
| CN115487280A (en) * | 2022-10-19 | 2022-12-20 | 浙江中医药大学 | Traditional Chinese medicine composition for relieving alcoholism, protecting liver and promoting liver regeneration, preparation and preparation method thereof |
| CN115777817A (en) * | 2022-12-20 | 2023-03-14 | 广东格林邦卡新材料生物科技有限公司 | Plant extraction composition for dispelling effects of alcohol, protecting liver and loosening bowel to relieve constipation, health tea and preparation method |
| CN115777817B (en) * | 2022-12-20 | 2024-04-26 | 湖北嫦娥生物股份有限公司 | Plant extract composition for dispelling effects of alcohol, protecting liver, moistening intestines and relaxing bowels, health tea and preparation method |
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| CN103859515A (en) * | 2014-03-26 | 2014-06-18 | 哈尔滨天合力制药有限公司 | Composite kudzu root and cherry drink and preparation method thereof |
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| CN109432386A (en) * | 2018-11-08 | 2019-03-08 | 武汉森澜生物科技有限公司 | A kind of corn peptide combinations of relieving alcoholism and protecting liver and preparation method thereof |
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| CN115487280A (en) * | 2022-10-19 | 2022-12-20 | 浙江中医药大学 | Traditional Chinese medicine composition for relieving alcoholism, protecting liver and promoting liver regeneration, preparation and preparation method thereof |
| CN115487280B (en) * | 2022-10-19 | 2023-12-19 | 浙江中医药大学 | Traditional Chinese medicine composition for dispelling effects of alcohol, protecting liver and promoting liver regeneration as well as preparation and preparation method thereof |
| CN115777817A (en) * | 2022-12-20 | 2023-03-14 | 广东格林邦卡新材料生物科技有限公司 | Plant extraction composition for dispelling effects of alcohol, protecting liver and loosening bowel to relieve constipation, health tea and preparation method |
| CN115777817B (en) * | 2022-12-20 | 2024-04-26 | 湖北嫦娥生物股份有限公司 | Plant extract composition for dispelling effects of alcohol, protecting liver, moistening intestines and relaxing bowels, health tea and preparation method |
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