CN103006921A - Composition having health care effects on cardiovascular and cerebrovascular anoxia and on toxicity of excess oxidation to human body, and preparation method thereof - Google Patents
Composition having health care effects on cardiovascular and cerebrovascular anoxia and on toxicity of excess oxidation to human body, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a composition having health care effects on cardiovascular and cerebrovascular anoxia and on toxicity of excess oxidation to a human body and a preparation method for the composition. The composition comprises a ginkgo biloba extract, a rhodiola root extract, a kudzu root extract, a grape seed extract and a wolfberry fruit extract, wherein the mass content of general flavone in the composition is 10 to 20%, and the mass content of rhodioloside is 1 to 5%. The preparation method for the composition comprises a step of extraction of the extracts from natural plant raw materials and a second step of uniformly mixing the extracts, wherein the extracts can be made into a capsule or tablet. The capsule or tablet of the composition has the advantages of no toxicity and side effects, a good curative effect and health care effects on cardiovascular and cerebrovascular anoxia and on toxicity of excess oxidation to the human body.
Description
Technical field
The present invention relates to a kind of health product, what be specifically related to is that the cardiovascular and cerebrovascular vessel anoxia is reached the compositions that human body excessive oxidation toxicity is had health-care effect.
Background technology
People replenish the understanding deficiency to having the food that improves anoxia endurance and antioxidation in daily life, and irrational dietary structure, be difficult to the raising anoxia endurance of picked-up q.s from diet and antioxidant with the deficiency of antioxidant reductase in the ability that improves anoxia in the body and the additional human body.Develop this product for the situation that improves anoxia endurance and antioxidant intake deficiency in people's diet, choose and have the raw material that improves anoxia endurance and anti-oxidation function, the convenient easily health food of clothes of exploitation, thus can weaken the interior anoxia of body to the extent of injury of body and remove the purpose that free radical too much in the body reaches slow down aging and prevention cardiovascular and cerebrovascular disease.The incidence rate of the aging of present domestic population, cardiovascular and cerebrovascular vessel and tumor disease sharply increases, but does not also treat preferably measure, and visible prophylactic generation is most important.
The mankind enter 21 century, allegro life, the condition of material life, along with science and technology is constantly maked rapid progress and is constantly improved, yet the excessive exploitation of earth resource, the environmental pollution that causes, made our living environment quality go from bad to worse, in with serious pollution like this environment, more accelerated anoxia to the injury of human body and the aging degree of human body, in addition, fast pace, high-intensity living environment makes increasing modern step into subhealth state, and medical model will be changed to the prevention and health care type by therapeutic type, and health food becomes the necessary of people's life the most at last.At home, the anti-oxidation function health food is all had an optimistic view of by manufacturing enterprise always.And have the anoxia endurance of raising and the bifunctional health food of antioxidation and few, along with human society steps into senescence, improving anoxia endurance and the proportion of antioxidant functional food in health industry will continue to increase.Therefore this product is put on market as the daily edible health food of people, and for this situation that China has a large amount of suitable crowds at present, wide market will be arranged.
Anoxia is a kind of stressor, can cause that body produces various irritability reactions.Cross strong or long-term oxygen deprivation stress and then can bring serious harm to body, finally can cause the important organs such as the body heart, brain dead because energy supply is not enough, also affect the oxidation energy supply of the various metabolism of body and body.The energy of body mainly obtains by aerobic metabolism, in strenuous exercise, and the ability supply that body requirement is a large amount of.When occurring supporting deficiency, myocyte's aerobic capacity reduces, and glycolysis is mobilized, and causes the lactic acid accumulation and produces tired.The raising of hypoxia ability, mainly be since the cell function of body to the adaptive change of anaerobic environment.
The interior free yl oxidation is the relevant bad reaction of biochemistry of people's energy i (in vivo) metabolism, confirm now: the generation of some diseases is because interference and the destruction of free radical have certain relation such as people's aging, the generation of tumor, deterioration, radiation damage, some heart, hepatopathy and the Refractory Shock etc. of inflammation with free radical with increasing the weight of.Under normal circumstances, remove rapidly but internal metabolism produces in a small amount of free radical body various antioxidant reductases etc., be unlikely to overheap, cause the damage of tissue and cell.But under the free radical scavenging systemic-function under the degradation abnormal conditions, cross polyradical and will cause various injuries in vivo.Interior free yl scavenging system function then depends on rational diet nutrition, to keep normal anti-oxidation function, the deficiency if various antioxidation nutrient substance are ingested for a long time will reduce anti-oxidation function, weakens body and removes the free radical ability and caused presenility and the generation other diseases.
Summary of the invention:
Technical problem to be solved by this invention is the defective that overcomes above-mentioned prior art, and purpose is to provide a kind of basic avirulence and side effect, the eutherapeutic compositions that has the cardiovascular and cerebrovascular vessel anoxia and human body excessive oxidation toxicity is had health-care effect.
Another object of the present invention is the preparation method that is to provide a kind of Simple fast of above-mentioned composition.
A further object of the invention is to be to provide a kind of basic avirulence and side effect, the eutherapeutic health product that cardiovascular and cerebrovascular vessel anoxia and human body excessive oxidation toxicity had health-care effect.
The invention provides a kind of compositions that cardiovascular and cerebrovascular vessel anoxia and human body excessive oxidation toxicity is had health-care effect, it is characterized in that, per 100 gram compositionss are comprised of the extract of following weight parts: Folium Ginkgo extract 5g-15g, Radix Rhodiolae extract 10g-20g, Radix Puerariae extract 40g-50g, Semen Vitis viniferae extract 10g-20g, Fructus Lycii extract are got thing 15g-20g; The mass content of total flavones is 10-20% in the described compositions, and the mass content of rhodioloside is 1-5%.
It is respectively to prepare by extracting in natural plant raw material Folium Ginkgo, Radix Rhodiolae, Radix Puerariae, Semen Vitis viniferae and the Fructus Lycii that described Folium Ginkgo extract, Radix Rhodiolae extract, Radix Puerariae extract, Semen Vitis viniferae extract and Fructus Lycii extract are got thing.
The present invention also provides a kind of preparation method of as mentioned above compositions, comprise following preparation process: the respectively preparation of the extract of (1) each composition: will use twice lixiviate of ethanol after the natural plant raw material chopping, the mixture that obtains after the lixiviate is filtered, and filtrate is concentrated, Recycled ethanol; The decorating film of concentrated rear gained again dilute with water is mixture solution, and wherein, the mass ratio of mixture solution and decorating film is 4:1; Described mixture solution is collected stripping liquid by after the chromatographic column chromatography, the concentrated and Recycled ethanol with stripping liquid, and the dry thing of gained is required after the drying; Described twice lixiviate: for the first time lixiviate is to be reflux, extract, 2.5～3.5h under the condition of 1:7～9 at the solid-liquid mass ratio with 60～65% ethanol with natural plant raw material, and the lixiviate second time is to be reflux, extract, 1.5～2.5h under the condition of 1:6～8 at the solid-liquid mass ratio with 60～65% ethanol; Described chromatography is with behind the mixed liquor upper prop after the dilution, first with clear water washing to the water of from post, emitting be colourless after, with 60～65% ethanol desorbings;
(2) extract of each composition of making is respectively sieved be mixed.
Natural plant raw material is chopped into the strip of 0.5-1.0cm length in the above-mentioned preparation method.
Recycled ethanol all is to be not more than 45 ℃ in temperature in the above-mentioned preparation method, vacuum is-0.8Mpa under, distilling under reduced pressure is reclaimed.
The present invention also provides a kind of health product that cardiovascular and cerebrovascular vessel anoxia and human body excessive oxidation toxicity had health-care effect, and above-described compositions is effective ingredient, adds corresponding pharmaceutical necessities and makes capsule or tablet.
Product of the present invention utilizes the Chinese Traditional Medicine health preserving theoretical, and in conjunction with the modern medicine theory, forms by formulated of the present invention take Folium Ginkgo extract, Radix Rhodiolae extract, Radix Puerariae extract, Semen Vitis viniferae extract and Fructus Lycii extract as primary raw material.Have definite functions, edible safety, quality controllable characteristics can be expected to reach and be improved anoxia endurance and oxidation-resisting health-care functional effect.
The medicine integration of edible and medicinal herbs that the present invention is selected, without any Side effect, its prescription property of medicine is better, can effectively improve human body cardio-cerebrovascular function and particularly the cardiovascular of middle-aged and elderly people be had health care and treatment meaning, as reduce the content of blood fat in the blood, cholesterol, triglyceride, reduce platelet aggregation and peroxide, the symptoms such as hyperpietic's headache, dizzy, cardiopalmus, tinnitus, insomnia, agitation, soreness of the waist and knees, numb limbs and tense tendons are improved significantly and regulating action.Good experiment effect of the present invention is concrete visible with lower specific implementation method.At the innovation initial stage of the present invention, choosing on the composition basis of above-mentioned 5 kinds of extracts, but still feeling to be still and to determine for the content of the composition of each extract.And the drawing of above scope in the technical solution of the present invention also is after the present invention passes through many times zoopery and failed trial, to sum up out gradually, and drawn the following good experiment effect of the present invention.
The specific embodiment
Capsule of the present invention improves the anoxia tolerant function test report
The l materials and methods
1.1 sample: adopting compositions of the present invention is that effective ingredient is made capsule, includes the bronzing powder, puts shady and cool dry place and preserves.The oral recommended dose of human body is x2 tablets/time x2 times/day of 0.45g/ grain, calculates with everyone 60kg body weight, amounts to dosage 0.03g/kg/ days.Get capsule 's content for subsequent use.
1.2 laboratory animal: 120 of the cleaning level Male Kunming strain mice that is provided by the laboratory animal department of the Chinese Academy of Sciences of University Of Nanhua, body weight is 18～22g, the laboratory animal production licence number is SCXK (Hunan) 2004-0009.
1.3 experimental situation condition: 22 ℃～24 ℃ of temperature, humidity 52%～58%, the laboratory animal occupancy permit number is SYXK (Hunan) 2003-0002 number.
1.4 animal grouping and dosage are selected: laboratory animal is divided into three large groups, 40 mices of every large group.Experiment I group is carried out the experiment of normal pressure anoxia enduring, and experiment II group is carried out the experiment of Ischemia Injury in Brain anoxia, experiment III group and carried out the sodium nitrite survival experiment of poisoning.Every large group is divided into four groups at random according to the weight of animals, every group of 10 mices.If being respectively 0.15g/kg*bw, 0.30g/kg*bw, 0.90g/kg*bw(, the basic, normal, high dosage of capsule of the present invention is equivalent to respectively 5,10,30 times of human body recommended dose).During test, take by weighing respectively Star's happy heart-soothing capsule content adding distil water of 1.50g, 3.00g, 9.00g madder to 200mL, be made into corresponding dosage and be subjected to test solution, press 0.2mL/l0g.bw volume gavage for each dosage group mice.The matched group gavage gives the equal-volume distilled water.Once a day, continuous 30 days.The experimental session animal drinking-water of freely ingesting.Observe activity and the growing state of animal every day.
1.5 instrument and reagent: electronic balance, 250mL wide mouthed bottle, inferior sour sodium, sodica calx, medical ventolin, operating scissors, stopwatch, tweezers, medicine spoon, 1mL syringe etc.
1.6 experimental technique:
1.6.1 normal pressure hypoxia endurance test: each organizes mice by 1.4 gavages 30 days, after the last gavage 1 hour, each group mice is put into respectively the 250mL port grinding bottle (1 every bottle) that fills the 5g sodica calx, seal bottleneck with vaseline, cover tightly, make it air tight, immediately timing, take respiratory arrest as index, observe mice because of the anoxia Post-dead duration.
16.2 sodium nitrite poisoning survival test: each organizes mice by 1.4 gavages 30 days, after the last gavage 1 hour, each treated animal is by 240mg/kg*bw dosage lumbar injection sodium nitrite (injection volume is 0.lmL/l0g*bw), and the animals survived time is recorded in immediately timing.
1.6.3 Ischemia Injury in Brain hypoxia test: each organizes mice by 1.4 gavages 30 days, after the last gavage 1 hour, each treated animal (under the ether light anaesthesia) from cervical region by broken end only, immediately by behind the stopwatch record mice broken end to the dwell time of breathing of dehiscing.
1.7 statistical analysis is processed: carry out data with Spss software and transform and add up bone and analyse.Relatively the time, first data are carried out homogeneity test of variance with the Spss software statistics, if variance is neat, adopt one factor analysis of variance totally to compare, find differences again and to carry out comparing in twos between a plurality of dosage groups and matched group mean with the Dunnett method.If heterogeneity of variance then carries out the conversion of suitable variable to initial data, satisfy homogeneity test of variance after, add up with the data after changing; If do not reach yet the neat purpose of variance after the variable conversion, use rank test instead and add up, find totally more variantly, then adopt the Tamhane'sT2 that does not require homogeneity of variance to check and compare in twos.
2 results
2.1 sample sees Table 1-5 to the impact of Mouse Weight.
Through the variance test of homogeneity, each organize mouse experiment just, experiment mid-term, that the experiment opisthosoma heavily reaches experimental session weight of mice variance is neat, adopts one factor analysis of variance, the result shows, the overall there was no significant difference (P〉0.05) relatively of These parameters between each group.
Table 1 capsule of the present invention improves anoxia endurance test I group Mouse Weight
Table 2 capsule of the present invention improves anoxia endurance test II group Mouse Weight
Table 3 capsule of the present invention improves anoxia endurance test III group Mouse Weight
2.2 sample sees Table 4 to the impact of mice Hypoxia under normal pressure.
Through the variance test of homogeneity, it is neat that each organizes mice Hypoxia under normal pressure variance, the one factor analysis of variance demonstration, overall relatively there was no significant difference between each group (P〉0.05).
Table 4 capsule of the present invention is on the impact of mice Hypoxia under normal pressure
2.3 sample is on the impact of poisoning time-to-live of mice sodium nitrite
Through the variance test of homogeneity, it is neat that each organizes mice sodium nitrite poisoning time-to-live variance, and one factor analysis of variance shows between each group significant difference (P=0.037) is arranged relatively totally.Further carry out a plurality of with the Durmett method
Comparing in twos between dosage group and matched group mean, the result shows that low dose group mice sodium nitrite poisons the time-to-live than matched group significant prolongation (P＜0.05 sees Table 5).
2.4 sample sees Table 6 to the impact of chmice acute cerebral ischemia anoxia time.
Through the variance test of homogeneity, it is neat that each organizes chmice acute cerebral ischemia anoxia time variance, and single factor program analysis shows between each group significant difference (P=0.012) is arranged relatively totally.Further carry out comparing in twos between a plurality of dosage groups and matched group mean with the Dunneit method, the result asks than matched group significant prolongation (P＜0.01) when showing low dose group mice normal pressure anoxia enduring.
Table 5 capsule of the present invention is on the impact of poisoning time-to-live of mice sodium nitrite
Table 6 capsule of the present invention is on the impact of anoxia time of chmice acute cerebral ischemia
3 conclusions
The per os gavage gives the capsule 's content of the present invention 30 days of mice 0.15/kg*bw, 0.30g/kg*bw, 0.90g/kg*bw dosage, 0.1Sg/kg*bw dosage can significant prolongation mice sodium nitrite poison time-to-live and Ischemia Injury in Brain anoxia time (P＜0.05 or P＜0.01.).To mice Hypoxia under normal pressure do not make significant difference (P〉0.05).The prompting submitted sample has the raising anoxia tolerant function.
Capsules On Anti oxidative function human experiment laboratory report of the present invention
1 materials and methods
1.1 sample
Capsule No.1 of the present invention, No. 2 provide by Hunan Qiangsheng Pharmacy Co., Ltd., and the two is basically identical on packing, outward appearance, color and luster and mouthfeel, and one of them is capsule of the present invention, and another is placebo, each two of human oral, every twice-daily.
1.2 the experimenter selects
1.2.1 inclusive criteria: experimenter's male or female.Age 45-65 year, physical condition is good, without obviously brain, the heart, liver, lung, kidney, Hematological Diseases, without the trial volunteer of Long-term taking medicine history and guarantee to cooperate.
1.2.2 experimenter's exclusion standard: gestation or women breast-feeding their children, to the health food allergy sufferers: merge have the inclination, the serious disease patients such as liver, kidney and hemopoietic system; Take in a short time the article relevant with tested function, have influence on judgement person as a result; Do not meet inclusive criteria, eat in accordance with regulations given the test agent, can't judge effect or data not umbra sound effect or safety judgement person.
1.3 experimental design and grouping
Adopt two kinds of control design between self and group.Be divided at random capsule test-meal group of the present invention and placebo group by experimenter's Serum MDA (MDA), superoxide dismutase (SOD), glutathion peroxidase (GSH-Px) level.And consider as far as possible affect result's principal element such as age, sex etc., and carry out harmony and check, with the comparability between the assurance group, carry out test-meal by double-blind method and test.
14 test methods
The trial volunteer of receiving eight standards and guaranteeing compatibility test be will meet, tested group and matched group will be divided at random.In on 09 27th, 2006, tested group with matched group take sample or placebo by recommended dose, continuous 180 days.Duration of test does not change original dietary habit, normal diet.
2 observation index
Each measures once every observation index when test-meal on-test and end.
2.1 safety indexes
2.1.1 general physical examination: inquire in detail and consult experimenter's utilized health card before the test, the situations such as understanding experimenter's spirit, sleep, diet, defecation, blood pressure, heart rate are carried out conventional physical examination and necessary lab testing to all experimenters.
2.1.2 routine blood test: red blood cell count(RBC), numeration of leukocyte, content of hemoglobin mensuration etc.
2.1.3 routine urinalysis: pH value, leukocyte, glucose in urine etc.
2.1.4 stool for routine: worm's ovum inspection etc.
2.1.5 biochemistry detection: total serum protein (TP), albumin (ALB), glutamate pyruvate transaminase (ALT), glutamic oxaloacetic transaminase, GOT (AST), cholesterol (CHOL), triglyceride (TG), blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA), blood glucose (GLU) are measured.
2.1.6 the inspections such as electrocardiogram, Abdominal B type ultrasonography, Chest X-rays.
2.1.7 untoward reaction is observed.
2.2 effect index
2.2.1 LPO: variation and the MDA rate of descent of MDA before and after the viewing test.
MDAX100% before MDA rate of descent=(the rear MDA of MDA-test before the test)/test
2.2.2 superoxide dismutase: the variation of SOD and the rate of rise of SOD before and after the viewing test.
SOD * 100% before SOD rate of rise=(the front SOD of SOD-test after the test)/test
2.2.3 glutathion peroxidase: the variation of GSH-Px and the rate of rise of GSH-Px before and after the viewing test.
GSH-Px * 100% before GSH-Px rate of rise=(the front GSH-Px of GSH-Px-test after the test)/test
3. the result judges
3.1 between group statistical significance is arranged more all after each functional observation index Test front and back self comparison and the test-meal, can judge this index.
3.2 each experimental result is positive in LPO, superoxide dismutase, three experiments of glutathion peroxidase, can judge that given the test agent has the anti-oxidation function effect.
4. statistical procedures.
Data result represents with mean ± standard deviation, self paired data adopts paired t-test, test group and the contrast knob between under the prerequisite of homogeneity of variance, mean relatively adopts in groups t check, otherwise adopt the t check after carrying out satisfying homogeneity of variance after variable transforms, if variance is still uneven, adopt rank test.
5. result
Double-blind method is observed and is finished to make known: take No. 2 persons and be capsule of the present invention, take No. 1 person and be placebo.
5.1 ordinary circumstance: initial trial crowd's test group 51 examples, matched group 51 examples, after test in 180 days, test group have 0 routine experimenter because of data not all or none method judge that curative effect is screened out, matched group have O example experimenter because of data not all or none method judge that curative effect is screened out.Last efficiency test crowd test group 51 examples, matched group 51 examples.Before and after the test-meal, experimenter's mental status, sleep state, defecation situation no abnormality seen.Matched group: male/female is 27/24, and the age is 53.84 ± 6.11; The test-meal group: male/female is 25/26, and the age is 53.90 ± 6.83.
5.2 safety is observed
5.2.1 body weight, blood pressure, heart rate, routine urinalysis, stool routine examination, routine blood test and biochemical indicator see Table 7,8.
Edible tested material is after 180 days, and test-meal group and matched group body weight, blood pressure, heart rate, routine urinalysis, stool routine examination, routine blood test and biochemical indicator are showed no obvious abnormalities variation, point out capsule of the present invention to body health without obvious damage.
Body weight before and after table 7 test-meal, blood pressure, heart rate, routine urinalysis, stool routine examination, routine blood test situation of change (x ± s)
Before and after table 8 test-meal at, index situation of change (x ± s)
5.2.2. electrocardiogram, Abdominal B type ultrasonography, Chest X-rays inspection are all within normal range.
5.2.3 have no the obviously untoward reaction relevant with sample during the test-meal.
5.3 functional observation
Serum MDA, the horizontal situation of change of SOD, GSH-Px see Table 9,10 before and after the test-meal test.Before the test, matched group and test-meal group serum MDA, SOD, GSH-Px level compare, and the P value is pointed out between two groups to have comparability all greater than 0.05.Compare before test-meal group GSH-Px in serum vigor and matched group and self test after the test, difference has significance (P＜0.05).Compare before test-meal group SOD in serum, MDA and matched group and self test after the test-meal, no significant difference (P〉0.05).The test group SOD in serum is tested front rising 9.10%, and serum MDA is tested front reduction by 10.24%, and the GSH-Px in serum vigor is tested front rising 15.55%.
Serum MDA, SOD, GSH-Px level are relatively before and after table 9 test-meal
Annotate: with * P＜O.05 relatively before the test-meal, with matched group #P＜O.05 relatively
Serum MDA, SOD, GSH-Px rate of change before and after table 10 test-meal
6. brief summary
The experimenter took tested material after 180 days, the result shows: test-meal group SOD in serum, GSH-Px vigor improve 9.10%, 15.55% before the test respectively after the test-meal, serum MDA is tested front reduction by 10.24%, wherein compare before GSH-Px vigor and matched group and self test, difference has significance (P＜0.05).The safety indexes such as blood, urine, stool routine examination, hepatic and renal function, electrocardiogram, B ultrasonic are showed no obvious abnormalities change before and after the test-meal, and do not find untoward reaction.The above results prompting submitted sample GSH-Px vigor experimental result is positive, and there is anti-oxidation function in the county.
Claims (6)
1. compositions that cardiovascular and cerebrovascular vessel anoxia and human body excessive oxidation toxicity is had health-care effect, it is characterized in that, per 100 gram compositionss are comprised of the extract of following weight parts: Folium Ginkgo extract 5g-15g, Radix Rhodiolae extract 10g-20g, Radix Puerariae extract 40g-50g, Semen Vitis viniferae extract 10g-20g, Fructus Lycii extract are got thing 15g-20g; The mass content of total flavones is 10-20% in the described compositions, and the mass content of rhodioloside is 1-5%.
2. it is respectively to prepare by extracting in natural plant raw material Folium Ginkgo, Radix Rhodiolae, Radix Puerariae, Semen Vitis viniferae and the Fructus Lycii that compositions according to claim 1, described Folium Ginkgo extract, Radix Rhodiolae extract, Radix Puerariae extract, Semen Vitis viniferae extract and Fructus Lycii extract are got thing.
3. the preparation method of the described compositions of claim 2, it is characterized in that, comprise following preparation process: the respectively preparation of the extract of (1) each composition: will use twice lixiviate of ethanol after the natural plant raw material chopping, the mixture that obtains after the lixiviate is filtered, and filtrate is concentrated, Recycled ethanol; The decorating film of concentrated rear gained again dilute with water is mixture solution, and wherein, the mass ratio of mixture solution and decorating film is 4:1; Described mixture solution is collected stripping liquid by after the chromatographic column chromatography; Concentrated and the Recycled ethanol with stripping liquid, the dry thing of dry rear gained is required; Described twice lixiviate: for the first time lixiviate is to be reflux, extract, 2.5～3.5h under the condition of 1:7～9 at the solid-liquid mass ratio with 60～65% ethanol with natural plant raw material, and the lixiviate second time is to be reflux, extract, 1.5～2.5h under the condition of 1:6～8 at the solid-liquid mass ratio with 60～65% ethanol; Described chromatography is with behind the mixed liquor upper prop after the dilution, first with clear water washing to the water of from post, emitting be colourless after, with 60～65% ethanol desorbings;
(2) extract of each composition of making is respectively sieved be mixed.
4. method as claimed in claim 3 is characterized in that, biological raw material is chopped into the strip of 0.5-1.0cm length.
5. method as claimed in claim 3 is characterized in that, wherein Recycled ethanol all is to be not more than 45 ℃ in temperature, vacuum is-0.8Mpa under, distilling under reduced pressure is reclaimed.
6. health product that cardiovascular and cerebrovascular vessel anoxia and human body excessive oxidation toxicity had health-care effect is characterized in that, take claim 1 or 2 described compositionss as effective ingredient, add corresponding pharmaceutical necessities and make capsule or tablet.
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Application publication date: 20130403 |