CN107669763A - A kind of compound blood fat reducing health products of sea grass polysaccharide and preparation method thereof - Google Patents
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Abstract
The present invention provides a kind of compound blood fat reducing health products of sea grass polysaccharide.The health products are capsule or tablet or particle electuary, and the health products are made up of following raw material：50 70 parts of sea grass polysaccharide extract, 10 15 parts of kudzu root extract, 5 10 parts of Herb Gynostemmae Pentaphylli extract, 5 10 parts of haw thorn extract, 10 15 parts of red yeast rice ferment, each raw material number is parts by weight.The present invention also provides the preparation method of above-mentioned health products, and above-mentioned raw materials are mixed according to above-mentioned parts by weight, is molded, and dries, and packs, and examines, obtains finished product.
Description
Technical field
The invention belongs to field of health care products, especially a kind of compound blood fat reducing health products of sea grass polysaccharide and preparation method thereof.
Background technology
Cardiovascular and cerebrovascular disease is the general designation of cardiovascular and cranial vascular disease, refers to due to hyperlipemia, blood viscousness, moves
The diseases such as heart disease, cerebral thrombus, cerebral hemorrhage caused by pulse atherosclerosis, hypertension.Cardiovascular and cerebrovascular disease is died from the whole world every year
The number of disease is up to 15,000,000 people, and it is the first to occupy the various causes of the death.
High fat of blood is to induce blood pressure elevated arch-criminal repeatedly.Blood viscousness, blood flow are obstructed, and blood can only rely on the power of blood flow
Amount, extruding blood vessel could be by the way that the pressure to blood vessel constantly increases, and forms hypertension.Blood fat blocks seriously, directly triggers brain
Thrombus.Blood vessel can be swarmed in when the crowded pressure of blood flow is excessive and such as fatal crisis of cerebral hemorrhage, apoplexy occurs.
Enteromorpha (Enteromorpha prolifera, EP), it is Chlorophyta sea lettuce also referred to as " marine green algae " or " green alga "
The algae of mesh Ulvaceae Enteromorpha, as the wild green alga in Tideland resources, natural propagation ability is strong and produces for it
Measure huge, possess very high development and utilization value.Polysaccharide is the main active of Enteromorpha, and there are some researches show Enteromorpha at present
Polysaccharide has blood fat reducing function.
Separately there are some researches show the active component containing reducing blood lipid and antioxidation such as hawthorn, lotus leaf, tealeaves, by this
A little raw materials are configured to compound sea grass polysaccharide with sea grass polysaccharide, are expected to that sea grass polysaccharide dosage can be reduced, reduce cost of material, have simultaneously
Mutiple Targets, the effect of multicomponent collaboration may be played in terms of reducing blood lipid.
2015, Chen Jie and Lin Wenting in《Dalian Medical Univ's journal》On delivered a entitled " compound sea grass polysaccharide
The scientific and technical literature of reducing blood lipid and lipoid peroxidization resistant research ", discloses a kind of compound sea grass polysaccharide in the scientific and technical literature（By
Sea grass polysaccharide, haw thorn extract, Lotus Leafextract and Tea Polyphenols each 25% are formulated）, to feed the rat of high lipid food work
For live body, the compound sea grass polysaccharide gavage is intervened into live body 45d, measure is found：With the rat phase of non-gavage compound sea grass polysaccharide
T-CHOL (TC), triglycerides (TG), low-density lipoprotein than, gavage in the serum of the rat of compound sea grass polysaccharide
White cholesterol（LDL-C）Decline；And HDL-C (HDL-C) increases, it is thought：This is compound
Sea grass polysaccharide has the function that reducing blood lipid.
In fact, author-Chen Jie and Lin Wenting above belongs to the cooperative development people of the present inventor, the present inventor's early stage
Also Centre for Disease Control of Fujian Province will be delivered to according to compound sea grass polysaccharide product made from above-mentioned compound sea grass polysaccharide formula by, which having, enters
Animal experiment is gone, measurement result is：Compared with the rat of non-gavage compound sea grass polysaccharide, gavage compound sea grass polysaccharide it is big
T-CHOL (TC), triglycerides (TG), LDL-C in the serum of mouse（LDL-C）Become without obvious
Change；And HDL-C (HDL-C) increases, still, the amplitude of raising is smaller（Refer to table 1 below）.Therefore,
The conclusion that Centre for Disease Control of Fujian Province provides is：According to《Auxiliary lipid-lowering function evaluation method》（State's food medicine prison guarantorization
2012 ］ No. 107）In criterion, it is believed that the product without auxiliary reducing blood lipid effect.In addition, the product also by
The staff of Shandong Center for Disease Control ＆ Prevention informs：Both rat and human body matrix differences are big, and it is right to carry out clinic
What patients ' lives were responsible for, and in view of sea grass polysaccharide belongs to cold in the formula of the product, lotus leaf and tealeaves belong to cool property, only hawthorn
Belong to warm nature, in the warm nature of hawthorn and cool property effect it is very limited so that the compound sea grass polysaccharide is obvious excessively cool, and it is to subject
Digestive system stimulate big, side effect is obvious, and therefore, it cannot be used for normal human trial.In addition, in fact, even if through
Animal experiment has the function that also often do not have auxiliary reducing blood lipid when aiding in the product of effect for reducing blood fat to be used for clinical test,
Reason is：Using real as study subject, the study subject through the rat that high lipid food is fed in short term in animal experiment
It is short-term high fat of blood on border, blood lipids index easily declines, and for the natural person with diabetes or high fat of blood, its
It is long-term high fat of blood, blood lipids index decline is simultaneously less easy.
The existing compound sea grass polysaccharide product of table 1. is to rat fat（Mmol/L, n=10）Influence
The content of the invention
It is an object of the present invention to provide a kind of compound blood fat reducing health products of sea grass polysaccharide.
A kind of compound blood fat reducing health products of sea grass polysaccharide, the health products are capsule or tablet or particle electuary, the health products
It is made up of following raw material：Sea grass polysaccharide extract 50-70 parts, kudzu root extract 10-15 parts, Herb Gynostemmae Pentaphylli extract 5-10 parts, mountain
Short, bristly hair or beard extract 5-10 parts, red yeast rice ferment 10-15 parts, each raw material number is parts by weight.
The two of the object of the invention are the preparation method for providing the above-mentioned health products.
A kind of preparation method of the compound blood fat reducing health products of sea grass polysaccharide, comprises the following steps：
（1）Sea grass polysaccharide extract 50-70 parts, kudzu root extract 10-15 parts, Herb Gynostemmae Pentaphylli extract 5-10 parts, mountain are weighed respectively
Short, bristly hair or beard extract 5-10 parts, red yeast rice ferment 10-15 parts, mixing, obtain mixed material；
（2）Mixed material is molded, dried, is packed, examines, obtains finished product.
The present inventor is first by sea grass polysaccharide extract, kudzu root extract, Herb Gynostemmae Pentaphylli extract, haw thorn extract, red yeast rice
Five kinds of medicine organic assemblings of ferment use, and take into account comprehensively, to expand therapeutic domain, adapt to the needs of the state of an illness, meanwhile, supervise medicine
Strong and toxicity, eliminate to human body may caused by unfavorable factor.Kudzu root extract, haw thorn extract and red yeast rice ferment therein
Element belongs to warm nature, has effectively neutralized the cold of sea grass polysaccharide extract, effectively reduces the stimulation to digestive system, and enhancing enteron aisle is inhaled
Receive.Sea grass polysaccharide molecular weight therein is big, it is not easy to by hyperlipemic patients intestinal absorption, utilizes red yeast rice ferment（Fermentation extraction
Active bio bacterium）To improve the absorptivity of sea grass polysaccharide, the advantage of complementation is added.Also, contained potassium element in sea grass polysaccharide
Content is up to 3.99%, can promote the excretion of sodium, also there is good protective effect to blood vessel, meanwhile, sea grass polysaccharide is still rich in magnesium
The treasure-house of element.Research shows, takes in magnesium, energy prevention and cure of cardiovascular disease, protects artery, the endodermis of blood vessel.Further, root of kudzu vine work(
It can cure mainly：Expand blood vessel；Pueraria Flavonid and Puerarin in the root of kudzu vine can improve the oxygen metabolism of cardiac muscle, while it is micro- to expand blood vessel
Circulation, vascular resistence is reduced, increases CBF；Flavonoid substances can increase the blood flow of brain and coronary vasodilator, Puerarin
Coronary vascular resistance can be declined, coronary blood-flow volume increase, while Puerarin also has obvious effect of lowering blood sugar.Herb Gynostemmae Pentaphylli extract
Lipid can be prevented in the deposition of vascular wall, raising immunologic function, adverse reaction etc. caused by suppression glucocorticoid.In addition,
The content of sea grass polysaccharide, the root of kudzu vine, gynostemma pentaphylla, hawthorn, red yeast rice ferment is also further defined by the present inventor, not only
Realize and lipid-lowering effect is brought up into optimum level, it is thus also avoided that the generation of side effect, through disease prevention and control center's human body
Experiment, it was demonstrated that the compound blood fat reducing health products of sea grass polysaccharide of the application can be used as auxiliary blood lipid-lowering medicine to use.
Embodiment
A kind of compound blood fat reducing health products of sea grass polysaccharide, the health products are capsule or tablet or particle electuary, the health products
It is made up of following raw material：Sea grass polysaccharide extract 50-70 parts, kudzu root extract 10-15 parts, Herb Gynostemmae Pentaphylli extract 5-10 parts, mountain
Short, bristly hair or beard extract 5-10 parts, red yeast rice ferment 10-15 parts, each raw material number is parts by weight.
A kind of preparation method of the compound blood fat reducing health products of sea grass polysaccharide, comprises the following steps：
（1）Sea grass polysaccharide extract 50-70 parts, kudzu root extract 10-15 parts, Herb Gynostemmae Pentaphylli extract 5-10 parts, mountain are weighed respectively
Short, bristly hair or beard extract 5-10 parts, red yeast rice ferment 10-15 parts, mixing, obtain mixed material；
（2）Mixed material is molded, dried, is packed, examines, obtains finished product.
Wherein, the sea grass polysaccharide extract in the above-mentioned a kind of compound blood fat reducing health products of sea grass polysaccharide and preparation method is equal
Prepared according to the sea grass polysaccharide extracting method of the patent disclosure of application number 201310028640.9.
According to step in a kind of preparation method of the above-mentioned compound blood fat reducing health products of sea grass polysaccharide（1）Obtained mixing is former
Material carries out following 3 embodiments, is now specifically listed as follows the experimental condition of this 3 embodiments（It is shown in Table 2）：
Table 2
| The content of sea grass polysaccharide extract（Part） | The content of kudzu root extract（Part） | The content of Herb Gynostemmae Pentaphylli extract（Part） | The content of haw thorn extract（Part） | The content of red yeast rice ferment（Part） | |
| Embodiment 1 | 50 | 15 | 10 | 10 | 15 |
| Embodiment 2 | 60 | 12 | 8 | 8 | 12 |
| Embodiment 3 | 70 | 10 | 5 | 5 | 10 |
The compound blood fat reducing health products mixed material of sea grass polysaccharide that 3 embodiments of the application obtain carries out animal experiment, respectively
Blank control group, model control group, rat TC, TG, LDL-C value of gavage test sample group are determined, concrete outcome is listed as follows
（It is shown in Table 3, the blood sampling object of the blank control group in table 3 is：Feed the normal rats of normal diet；The blood sampling of model control group
Object is：Feed the rat of the non-gavage given the test agent of high lipid food；Embodiment 1-3 object is：Feed high lipid food and high agent
Measure the rat of gavage given the test agent）：
Table 3
The partial data that data in above-mentioned table 3 for the present inventor intercept in testing many times.As can be seen from Table 3, implement
Rat TC, TG, LDL-C value of example 1-3 gavage test sample group significantly decrease relative to model control group, and HDL-
C values have obvious rise relative to model control group.Therefore, the compound blood fat reducing health products mixing of sea grass polysaccharide of the invention is former
Material has auxiliary effect for reducing blood fat.
In addition, the compound blood fat reducing health products mixed material of sea grass polysaccharide that the present inventor obtains above-described embodiment 1 delivers to good fortune
Jian Sheng disease prevention and control centers carry out animal experiment（Registration Test accepts numbering：The strong 13-0173 of Min Jikongzhongxinwei inspections, report
Accuse book numbering：The strong 13-0173-3 of Min Jikongzhongxinwei inspections）, inspection result is as follows（Refer to table 4 below）：Using mixed type hyperlipemia
Disease animal model, after modeling 7 days, model control group serum cholesterol（TC）, triglycerides（TG）, LDL-C
（LDL-C）Value is higher than blank control group, and difference is statistically significant（P ＜ 0.05）, decision model establishment.Gavage is given by oral administration
After giving given the test agent 30 days, model control group TC, TG, LDL-C value are higher than blank control group, and difference is statistically significant（P ＜
0.05）；High dose group（That is gavage test sample group）Rat TC, TG value are less than model control group, and difference is statistically significant
（P ＜ 0.05）, LDL-C values are compared with model control group, no significant difference（P ＞ 0.05）.According to《Aid in reducing blood lipid work(
Can evaluation method》（State's food medicine prison guarantorization ［ 2012 ］ 107）In criterion, it is believed that the compound antilipemic healthy of the sea grass polysaccharide
Product mixed material plays the role of to aid in reducing blood lipid.
The compound blood fat reducing health products mixed material of sea grass polysaccharide of the present invention of table 4. is to rat fat（Mmol/L, n=
10）Influence
The present inventor again by according to the present invention the compound blood fat reducing health products preparation method of sea grass polysaccharide made from above-mentioned Enteromorpha
The compound blood fat reducing health products of formula identical sea grass polysaccharide of polysaccharide composite blood fat reducing health products mixed material deliver to Shandong Province's disease
Sick prevention and control center carries out human trial（Sample number into spectrum：GZ03920140305）, result of the test is as follows：Using itself and group
Between counter point, 102 hyperlipemia subjects, test-meal group 51, control group 51.Diet and habits and customs are not during test-meal
Become, test-meal group takes test specimen, and control group uses blank control, continuously takes 60 days.Serum cholesterol after test-meal（TC）Compared with
0.51 ± 0.39mmol/L is have dropped before test-meal, difference has conspicuousness（P ＜ 0.01）；Triglycerides（TG）It has dropped 0.28 ±
0.19mmol/L, difference have conspicuousness（P ＜ 0.01）；LDL-C（LDL-C）It has dropped 0.19 ±
0.18mmol/L, difference have conspicuousness（P ＜ 0.01）；It is brighter between test-meal group and control group group after TC, TG binomial index test-meal
Aobvious to reduce, difference has conspicuousness（P ＜ 0.01）, obvious reduction, difference have between test-meal group and control group group after LDL-C test-meals
Conspicuousness（P ＜ 0.01）；Test-meal group total effective rate is significantly higher than control group（P ＜ 0.01）, test structure show that the tested material has
Auxiliary lipid-lowering function.Blood, urine, feces routine and total serum protein, albumin, glutamic-oxalacetic transaminease, glutamic-pyruvic transaminase, urine after test-meal
Every safety indexes inspection such as plain nitrogen, creatinine, uric acid, blood glucose.Subject in normal range (NR), illustrates the subject to test-meal
Person's health has no adverse effects.General status during test-meal（Including spirit, sleep, diet, body weight, stool and urine, blood pressure,
Heart rate etc.）Normally, allergy and other adverse reactions are not observed.
Certainly, the sea grass polysaccharide extract in a kind of compound blood fat reducing health products of sea grass polysaccharide and preparation method of the invention
It is also limited to prepare according to the sea grass polysaccharide extracting method of the patent disclosure of application number 201310028640.9.
Claims (2)
1. a kind of compound blood fat reducing health products of sea grass polysaccharide, the health products are capsule or tablet or particle electuary, it is characterised in that：
The health products are made up of following raw material：Sea grass polysaccharide extract 50-70 parts, kudzu root extract 10-15 parts, Herb Gynostemmae Pentaphylli extract 5-
10 parts, haw thorn extract 5-10 parts, red yeast rice ferment 10-15 parts, each raw material number is parts by weight.
A kind of a kind of 2. preparation method of the compound blood fat reducing health products of sea grass polysaccharide described in claim 1, it is characterised in that bag
Include following steps：
（1）Sea grass polysaccharide extract 50-70 parts, kudzu root extract 10-15 parts, Herb Gynostemmae Pentaphylli extract 5-10 parts, mountain are weighed respectively
Short, bristly hair or beard extract 5-10 parts, red yeast rice ferment 10-15 parts, mixing, obtain mixed material；
（2）Mixed material is molded, dried, is packed, examines, obtains finished product.
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| PCT/CN2018/107271 WO2019100843A1 (en) | 2017-08-17 | 2018-09-25 | Enteromorpha prolifera polysaccharide composite blood lipid-lowering health care product and preparation method therefor |
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| CN2017107054985 | 2017-08-17 | ||
| CN201710705498 | 2017-08-17 |
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|---|---|---|---|---|
| WO2019100843A1 (en) * | 2017-08-17 | 2019-05-31 | 福建海兴保健食品有限公司 | Enteromorpha prolifera polysaccharide composite blood lipid-lowering health care product and preparation method therefor |
| CN113559114A (en) * | 2021-09-26 | 2021-10-29 | 汇泰渤海水产有限责任公司 | Application of enteromorpha polysaccharide in reducing foam cell lipid accumulation |
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| CN101518595A (en) * | 2008-02-28 | 2009-09-02 | 北京中泰天和科技有限公司 | Medical composition with functions of lowering lipid, reducing fat and oxidation resistance and preparation method thereof |
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| CN105726628A (en) * | 2016-03-30 | 2016-07-06 | 福建农林大学 | Compound enteromorpha polysaccharide composition with anti-EV71 virus effect |
| CN107669763B (en) * | 2017-08-17 | 2021-01-19 | 福建海兴保健食品有限公司 | Enteromorpha polysaccharide compound auxiliary blood fat reducing health-care product and preparation method thereof |
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| CN101518595A (en) * | 2008-02-28 | 2009-09-02 | 北京中泰天和科技有限公司 | Medical composition with functions of lowering lipid, reducing fat and oxidation resistance and preparation method thereof |
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| 孙安迪: "《超强抗病力 免疫权威的独门养生法》", 28 February 2015, 青岛出版社 * |
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|---|---|---|---|---|
| WO2019100843A1 (en) * | 2017-08-17 | 2019-05-31 | 福建海兴保健食品有限公司 | Enteromorpha prolifera polysaccharide composite blood lipid-lowering health care product and preparation method therefor |
| CN113559114A (en) * | 2021-09-26 | 2021-10-29 | 汇泰渤海水产有限责任公司 | Application of enteromorpha polysaccharide in reducing foam cell lipid accumulation |
| CN113559114B (en) * | 2021-09-26 | 2022-01-18 | 汇泰渤海水产有限责任公司 | Application of enteromorpha polysaccharide in reducing foam cell lipid accumulation |
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| WO2019100843A1 (en) | 2019-05-31 |
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