CN104523829B - A kind of propolis Radix Salviae Miltiorrhizae health food - Google Patents
A kind of propolis Radix Salviae Miltiorrhizae health food Download PDFInfo
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- CN104523829B CN104523829B CN201410785701.0A CN201410785701A CN104523829B CN 104523829 B CN104523829 B CN 104523829B CN 201410785701 A CN201410785701 A CN 201410785701A CN 104523829 B CN104523829 B CN 104523829B
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Abstract
The present invention relates to a kind of propolis Radix Salviae Miltiorrhizae health foods, comprise the following components in percentage by weight：Propolis 6% 18%, Salvia root P.E 6% 18%, gadol extract 4% 18%, squash polyoses 4% 16%, oenothera odorata oil 40% 55%, auxiliary material 5% 10%.It can be made into soft capsule.Propolis in the present invention, Salvia root P.E, gadol extract blood pressure lowering, blood fat, blood glucose, compounding use can have synergistic effect simultaneously, arrange in pairs or groups oenothera odorata oil and squash polyoses, the unrighted acid of high-content to invention effect more preferably.Raw material composition of the present invention is simple, reasonable, and ingredient is natural, and proportioning is appropriate, convenient to take, safe, without toxic side effect, has no adverse reaction, and will not generate dependence effect, is suitble to long-term use of.Have effects that reduce blood fat and blood glucose.
Description
Technical field
The present invention relates to a kind of health food, specifically a kind of propolis Radix Salviae Miltiorrhizae health food.
Background technology
Hyperlipidemia, hypertension, hyperglycaemia are referred to as " three high ", are to threaten diabetic's health and the main hazard of life
Factor.Three is closely related, and hyperlipidemia can aggravate diabetes, so diabetic is in addition to hyperglycaemia is treated, it is also necessary to adjust
Blood fat is the key that reduce diabetic's death rate and disability rate.Diabetic should be noted that adjusting blood fat：Diabetes merge
Hyperlipidemia is easier to cause headstroke, coronary heart disease, limb necrosis, eyeground pathological changes, renal lesions, neuropathy etc., these glycosurias
The long term complication of disease is the main reason for causing diabetic's deformity or premature death.There are about 1.6 hundred million sugar at present in the whole world
Patient is urinated, the death rate ranks the 3rd.Great harm is generated to human health.Reducing blood sugar and blood lipid is mostly with change currently on the market
It learns based on synthetic drug, easily generates dependence, and easily generate complication.And Hypoglycemic Constituents of Natural Products has following spy
Point：1. action temperature and, stablize and persistently；2. toxic reaction is very low；3. generally have the work(such as reducing blood lipid and platelet aggregation-against concurrently
Energy；4. in natural products, usual a variety of sugar-lowering components are simultaneously deposited；5. most of Hypoglycemic Constituents of Natural Products properties are stablized, can lead to
Oral medication is crossed, it is convenient to take.
The content of the invention
The technical problems to be solved by the invention are to overcome above-mentioned the deficiencies in the prior art, provide a kind of raw material composition letter
Single, reasonable, ingredient is natural, and proportioning is appropriate, convenient to take, has effects that the propolis Radix Salviae Miltiorrhizae health food for reducing blood fat and blood glucose.
The present invention solve above-mentioned technical problem the technical solution adopted is that：A kind of propolis Radix Salviae Miltiorrhizae health food, feature exist
In：It is comprised the following components in percentage by weight：Propolis 12%, Salvia root P.E 12%, gadol extract 12%, pumpkin
Polysaccharide 8%, oenothera odorata oil 49%, auxiliary material 7%, the auxiliary material are made of phosphatide, beeswax, and the weight percent of the phosphatide is
3%, beeswax 4%, the content of tanshinone is 10% in Salvia root P.E, and the content of rhodioside is in gadol extract
2%, gamma -linolenic acid content is 8%-14% in oenothera odorata oil.
Soft capsule content prepared by the present invention is suspension feed liquid, can pass through dispensing, pelleting, drying, wash the processes systems such as ball
Into soft capsule, the weight-losing soft capsules food that content content is 500mg-750mg/ is produced.The flexible glue utricule be by
The preparations such as gelatin, glycerine, water.
Usage and dosage of the present invention are：Daily recommended amounts of being grown up are 1000mg/60kg.BW.It is by human body recommended intake
2 times a day, 1-2 tablets each time, imitated for the sake of 15 days, it can be long-term use of.
Flavonoid substances, polysaccharide material in the present invention in propolis, which have, adjusts body metabolism, enhances the work of immunocompetence
With.Salvia root P.E purchase tanshinone content is more than 10%, can increase coronary flow, improve myocardial ischemia, infraction and heart work(
Can, the rhythm of the heart is adjusted, and peripheral blood vessel can be expanded, improve microcirculation.Determination of Salidroside is 2% in gadol extract, can be promoted
Into the metabolism of cholesterol and fat, blood viscosity is reduced, anti-platelet aggregation reduces the blood fat of hyperlipemia, antithrombotic shape
Into.Squash polyoses can efficiently control the symptom of diabetes, and may be because promoting the secretion of insulin, and reaching reduces blood glucose
Effect.Oenothera odorata oil is rich in aliphatic acid (20%-25%), enzyme and various bioactivators, wherein gamma-Linolenic acid (GLA)
Content is up to 8%-14%, and metabolite can prevent blood lipid deposition, inhibits platelet aggregation, to cardiovascular and cerebrovascular diseases, diabetes,
Rheumatism etc. is all effective in cure.Propolis and Salvia root P.E of the present invention, gadol extract contain substantial amounts of flavones, glycoside, ketone
Substance can prevent that lipoid material from too being absorbed, and may also suppress the synthesis of cholesterol, remove the rubbish in blood, painstaking effort in time
Pipe is protected simultaneously, has built a good human body environment, and triple combination is enhanced using synergistic effect, and effect is more notable.Make
The glucose utilization of high sugar HepG 2 cell line increases, and the glucose utilization of the HepG2 cells of insulin stimulating is increased
Added with synergistic effect, the blood glucose of diabetic mice caused by alloxan can be reduced.Squash polyoses and oenothera odorata oil contain a large amount of battalion
Element is supported, can meet the needs of human body is to nutriment, while it is excessive to be unlikely to fat and sugar class material absorbing again.The two is assisted
Same-action enhances, and effect is more notable.Squash polyoses simultaneously can acetin liver T lymphocytes generation, increase liver functions of expelling toxin,
Enhance the ability of liver glycogen biosynthesis, it is horizontal to reduce Xue Tiangang in blood.The unsaturated fatty acids contained have linoleic acid, α-
Leukotrienes, DHA and EPA etc., except can lipid-loweringing, reduce serum cholesterol in addition to, also have blood sugar reducing function.
Raw material composition of the present invention is simple, reasonable, and ingredient is natural, and proportioning is appropriate, convenient to take, safe, without poison pair
Effect, has no adverse reaction, and will not generate dependence effect, be suitble to long-term use.Have effects that reduce blood fat and blood glucose.
Specific embodiment
In conjunction with embodiment, the present invention will be further described.
A kind of propolis Radix Salviae Miltiorrhizae health food, comprises the following components in percentage by weight：Propolis 6%-18%, Radix Salviae Miltiorrhizae carry
Take object 6%-18%, gadol extract 4%-18%, squash polyoses 4%-16%, oenothera odorata oil 40%-55%, auxiliary material 5%-
10%.It can be made into soft capsule.
Further preferred embodiment is that the weight percent of each component is：Propolis 12%, Salvia root P.E 12%,
Gadol extract 12%, squash polyoses 8%, oenothera odorata oil 49%, auxiliary material 7%.
Further, the auxiliary material is made of phosphatide, beeswax, and the weight percent of the phosphatide is 2%-5%, and beeswax is
3%-5%.
Soft capsule content of the present invention is suspension feed liquid, can pass through dispensing, pelleting, drying, wash the processes such as ball flexible glue is made
Capsule produces the weight-losing soft capsules food that content content is 500mg-750mg/.The flexible glue utricule is by gelatin, sweet
The preparations such as oil, water.The specific preparation process of soft capsule of the present invention belongs to the prior art, repeats no more.
Usage and dosage of the present invention are：Daily recommended amounts of being grown up are 1000mg/60kg.BW.It is by human body recommended intake
2 times a day, 1-2 tablets each time, imitated for the sake of 15 days, it can be long-term use of.
Each component effect is as follows in the present invention.Propolis can improve body's immunity, increase disease resistance.In propolis
Flavonoid substances, polysaccharide material, which have, adjusts body metabolism, enhances the effect of immunocompetence.Propolis energy antibacterial, it is antiviral, resist true
Bacterium, antiprotozoan.The active ingredient killed the virus in propolis rich in Galangin, Kaempferol, Quercetin, isopentyl ferulate etc..
Propolis can be solved liver poison, had treatment and protection to acute, chronic hepatitis, fatty liver, hepatic sclerosis and a variety of toxic liver injuries with protect liver
Effect.Research also confirms that the lignanoid in propolis can improve influence of the poisonous substance to liver, promote the recovery of liver cell.Bee
Glue has good anticancer, antitumor action, can mitigate radiotherapy, side effects of chemotherapy.Propolis can adjust blood glucose, increase hypoglycemic medication
Effect improves diabetic symptom, prevents diabetic complication.Flavonoids and terpenoid substance in propolis, which have, promotes exogenous Portugal
The effect of grape sugar synthesis hepatic glycogen and bidirectional modulation blood glucose, can significantly reduce blood glucose.Propolis can adjust blood fat, reduce excessively high
Cholesterol, triglyceride and low-density albumen, increasing high density lipoprotein.Propolis can soften blood vessel, enhance antiotasis, drop
The permeability of low fragility of blood vessels and exception.
Salvia root P.E is purchased from Hanzhong day Rangu, tanshinone content 10%.Its energy coronary artery dilator, increases coronary artery stream
Amount improves myocardial ischemia, infraction and cardiac function, adjusts the rhythm of the heart, and can expand peripheral blood vessel, improves microcirculation；Machine can be improved
Body hypoxia-bearing capability；There is anticoagulation, promote fibrinolytic, inhibit platelet aggregation, the effect of inhibition thrombosis；Blood fat can be reduced,
Inhibit coronary atherosclerosis to be formed；It can inhibit or mitigate degeneration of liver cells, necrosis and inflammatory reaction, promote liver cell regeneration, and
There is anti-fibrosis effect；The convalescence of red blood cell and hemochrome can be shortened, increase Reticulocyte, the reparation of tissue can be promoted,
Accelerate the healing of fracture；There is nervous centralis to have inhibitory action；There is antitumor action；Body's immunity can be enhanced；Blood can be reduced
Sugar；There is inhibitory action to various bacterias such as tubercle bacilluses.
Gadol extract is purchased from Hanzhong day Rangu, Determination of Salidroside 2%.It can promote the generation of cholesterol and fat
It thanks, reduction blood viscosity, anti-platelet aggregation, reduces the blood fat (triglyceride) of hyperlipemia, antithrombus formation makes them
It is not deposited on blood vessel, so as to prevent the generation of cardiovascular and cerebrovascular diseases and development.Rhodiola root can reduce the load of heart, improve heart
Function can enhance the blood-pumping function of Ischemic Heart, accelerate blood flow, correct the cardiac blood caused by ischemic to a certain extent and flow
The disorder of mechanics；Because it has effects that QI invigorating, promoting blood circulation, change are become silted up, blood vessel rubbish can be removed, improves amount of hemoglobin, is improved
The oxygen content of blood, therefore there is protective effect to myocardial anoxia, and impaired cardiac muscle cell can be repaired, recover heart vigor, make
With better than compound Danshen Root；Rhodiola root can reduce the area of myocardial infarction；Rhodioloside and ketone can significantly reduce blood pressure in short time.
Squash polyoses are purchased from the bright biology in side, content 30%.Cucurbita cucurbitaceous plant, pulp is rich in amino acid, albumen
Matter, cellulose, starch, trigonelline, carbohydrate and part trace element.Pumpkin have tonifying middle-Jiao and Qi, toxin expelling, reduce blood pressure and
Cholesterol and other effects particularly has diabetes extraordinary curative effect.Pumpkin contains abundant cobalt, containing brill in all kinds of vegetables
Amount ranks first.Cobalt can enliven the metabolism of human body, promote hematopoiesis function, and in participant's body vitamin B12 synthesis, be people
Micro- necessary to body islet cells, to preventing diabetes, reducing blood glucose has the effect of special.In recent years, both at home and abroad
Useful pumpkin powder is reported to treat the example of diabetes.It is demonstrated experimentally that squash polyoses can reduce alloxan diabetes rats
Fasting blood sugar, and animal subject general activity situation becomes multiple normal, this shows that squash polyoses can efficiently control diabetes
Symptom, and may be because promoting the secretion of insulin, and have the function that reduce blood glucose.
Oenothera odorata oil is rich in aliphatic acid (20%-25%), enzyme and various bioactivators, wherein gamma-Linolenic acid
(GLA) content is up to 8%-14%, and metabolite can prevent blood lipid deposition, inhibit platelet aggregation, to cardiovascular and cerebrovascular diseases, sugar
Urine disease, rheumatism etc. are all effective in cure, it is demonstrated experimentally that oenothera odorata oil can lower the blood glucose, blood fat and the formation for inhibiting thrombus of white mouse,
It is the vegetable oil of new type health.
Propolis and Radix Salviae Miltiorrhizae of the present invention, gadol extract contains substantial amounts of flavones, glycoside, letones can prevent fats
Substance is too absorbed, and may also suppress the synthesis of cholesterol, removes the rubbish in blood in time, and angiocarpy is protected simultaneously, is built
One good human body environment.Triple combination increases the glucose utilization of high sugared HepG 2 cell line, to pancreas
The glucose utilization increase for the HepG2 cells that island element stimulates has synergistic effect, can reduce diabetic mice caused by alloxan
Blood glucose.Squash polyoses and oenothera odorata oil contain macronutrient, can meet the needs of human body is to nutriment, while again
It is excessive to be unlikely to fat and sugar class material absorbing.Squash polyoses simultaneously can acetin liver T lymphocytes generation, increase liver toxin expelling
Function enhances the ability of liver glycogen biosynthesis, horizontal to reduce Xue Tiangang in blood.The unsaturated fatty acids that the two contains have
Linoleic acid, alpha-linolenic acid, DHA and EPA etc., except can lipid-loweringing, reduce serum cholesterol in addition to, also have blood sugar reducing function.
For the various composition of the present invention all there are many effect, component is natural, all with a variety of natural active matters, synergistic effect
Enhancing so that product compatibility more science, effect are more notable.Can simultaneously blood pressure lowering, blood fat, blood glucose.Three is avoided one
Mutually converting under fixed condition.The present invention is safe, without toxic side effect, has no adverse reaction, and will not generate dependence effect,
It is suitble to long-term use.
Embodiment 1：A kind of propolis Radix Salviae Miltiorrhizae health food, consisting of propolis 6%, Salvia root P.E 18%, rhodiola root carry
Take object 4%, squash polyoses 16%, oenothera odorata oil 47%, beeswax 2%, phosphatidase 5 %.
Embodiment 2：A kind of propolis Radix Salviae Miltiorrhizae health food, consisting of propolis 18%, Salvia root P.E 6%, rhodiola root carry
Take object 18%, squash polyoses 4%, oenothera odorata oil 46%, beeswax 5%, phosphatidase 3 %.
Embodiment 3：A kind of propolis Radix Salviae Miltiorrhizae health food, consisting of propolis 12%, Salvia root P.E 12%, rhodiola root carry
Take object 12%, squash polyoses 8%, oenothera odorata oil 49%, beeswax 4%, phosphatidase 3 %.
Finished product involved by embodiment 1-3 is to be pressed into soft capsule according to soft capsule technique.
Illustrate various functions that the invention has below by zoopery.
1. material and method
1.1 sample：Embodiment 1-3 soft capsules, human oral's recommended dose are daily 2g, are calculated with everyone 60kg weight,
Equivalent dosage is 0.033g/kg.bw.
1.2 experimental animals and environmental condition：SPF grades of male SD rats 50 are only by Changsha Kaifu District Dong Chuan experimental animals section
Skill service department provides, experimental animal production licence number SCXK (Hunan) 2009-0012.Feed is provided by same unit.Test item
Part is barrier environment, and during the experiment experimental situation temperature is 22-24 DEG C, humidity 52%-56%.Experimental animal uses credit number
For SYXK (Hunan) 2005-0001.
1.3 high lipid food：78.8% basal feed, 1% cholesterol, 10% yolk powder, 10% lard, 0.2% cholate are planted
Object oil.
1.4 alloxan causes diabetes group：When mouse fasting 12 is small after pneumoretroperitoneum injection alloxan 200mg/kg, 3d,
Fasting 5h.
1.5 experimental method：
1.5.1 dose design：According to human oral's recommended amounts, if soft capsule embodiment 1-3 is respectively 0.33g/kg.bw
(10 times that are equivalent to human body recommended amounts).According to the dosage to rat oral gavage, once a day, continuous gavage 30 days.Compare gavage
Group gives isometric solvent.
1.5.2 animal packet：Rat observation is fed with basal feed after a week, and fasting 16h takes tail blood, measures cholesterol, sweet
Oily three esters, high-density lipoprotein, take into account TG according to TC levels and animal are divided to four groups at random：Control group high in fat and embodiment 1-3 tetra-
A tested material group.Since formal test, each group animal uses high lipid food instead, at the same according to 1.5.1 dose designs to each group by
Try animal gavage.Cutting tail point takes blood to survey blood glucose, and it is diabetic mice to filter out fasting blood-glucose in the mouse of more than 11.1mol/l,
It is fed respectively by embodiment 1-3, medication therapy groups are positive controls.30d posterior orbits take blood, measure blood glucose value.
1.5.3 index determining：Off-test fasting 16h pulls out eyeball blood sampling and measures serum TG, TC, HDL-C.
1.6 data processing：Data excel, spss11.0 software carry out statistical analysis.
2 results
Influence of 2.1 samples to Serum TC.
It is horizontal that table 1 tests front and rear each group Serum TC
Influence of 2.2 samples to rat blood serum TG.
It is horizontal that table 2 tests front and rear each group rat blood serum TG
Influence of 2.3 samples to rat blood serum HDL-C.
It is horizontal that table 3 tests front and rear each group rat blood serum HDL-C
Influence of 2.4 samples to rat blood sugar value.
It is horizontal that table 4 tests front and rear each group rat blood sugar
After experiment, control group serum TC high in fat, TG, HDL-C are significantly raised, and compared with before experiment, difference has notable
Property (P ＜ 0.05), show modeling success.Compared with control group high in fat, embodiment 1-3 can significantly reduce the total courage of rat blood serum and consolidate
Alcohol and triglyceride levels (P ＜ 0.05), each dosage do not make significant difference to rat blood serum high-density lipoprotein cholesterol (P ＞
0.05).Therefore the product has auxiliary lipid-lowering function to animal.It can be seen from Table 4 that rat blood sugar level is bright after experiment
It is aobvious to reduce, wherein changing maximum with embodiment 3.Therefore it can judge that the invention plays an important role of to reduce blood-fat and blood sugar simultaneously.
Claims (1)
1. a kind of propolis Radix Salviae Miltiorrhizae health food, it is characterised in that：It is comprised the following components in percentage by weight：Propolis 12%,
Salvia root P.E 12%, gadol extract 12%, squash polyoses 8%, oenothera odorata oil 49%, auxiliary material 7%, the auxiliary material is by phosphorus
Fat, beeswax composition, the weight percent of the phosphatide is 3%, beeswax 4%；The content of tanshinone in the Salvia root P.E
For 10%, the content of rhodioside is 2% in the gadol extract, and gamma -linolenic acid content is in the oenothera odorata oil
8%-14%.
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| CN105533596A (en) * | 2015-12-14 | 2016-05-04 | 山东天地健生物工程有限公司 | Propolis, radix salviae miltiorrhizae and ginkgo leaf capsules and preparation method thereof |
| CN105495617A (en) * | 2015-12-18 | 2016-04-20 | 新疆维阿堂制药有限公司 | Health-care food capable of losing weight and assisting in blood lipid reduction and preparation method thereof |
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| CN1679851A (en) * | 2005-01-18 | 2005-10-12 | 辽宁东宁药业有限公司 | Bee product tablets for diabetes and their making method |
| CN1864708A (en) * | 2005-05-17 | 2006-11-22 | 张亚斌 | Blood sugar-decreasing health food |
| CN103622027A (en) * | 2013-12-18 | 2014-03-12 | 绿之韵生物工程集团有限公司 | Health-care food composition for reducing blood glucose |
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2014
- 2014-12-18 CN CN201410785701.0A patent/CN104523829B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679851A (en) * | 2005-01-18 | 2005-10-12 | 辽宁东宁药业有限公司 | Bee product tablets for diabetes and their making method |
| CN1864708A (en) * | 2005-05-17 | 2006-11-22 | 张亚斌 | Blood sugar-decreasing health food |
| CN103622027A (en) * | 2013-12-18 | 2014-03-12 | 绿之韵生物工程集团有限公司 | Health-care food composition for reducing blood glucose |
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| 中国已获批准的保健食品现状分析;束云等;《中国食品卫生杂志》;20061231;第18卷(第5期);第401-405页 * |
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