CN104256618A - Food, health care product or medicine composition with blood sugar reduction function - Google Patents

Food, health care product or medicine composition with blood sugar reduction function Download PDF

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Publication number
CN104256618A
CN104256618A CN201410542588.3A CN201410542588A CN104256618A CN 104256618 A CN104256618 A CN 104256618A CN 201410542588 A CN201410542588 A CN 201410542588A CN 104256618 A CN104256618 A CN 104256618A
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parts
food
health products
pharmaceutical composition
raw material
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CN104256618B (en
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胡娜
周武
索有瑞
尤志海
舒红辉
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QINGHAI TANGGUTE BIOTECHNOLOGY Co Ltd
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QINGHAI TANGGUTE BIOTECHNOLOGY Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention provides food, health care product or medicine composition with a blood sugar reduction function. The food, health care product or medicine composition comprises components of raw materials in parts by weight as follows: 1-5 parts of sanvitalia procumbens, 3-7 parts of lycium ruthenicum murray, 5-10 parts of nitraria tangutorum bobr, 5-10 parts of folium lycii, 5-15 parts of flos carthami and 5-15 parts of seabuckthorn leaves. Research finds that raw materials are compatibly matched and used, the synergistic interaction is exerted, and the blood sugar reduction effect is remarkably superior to that of other matched prescription; and meanwhile, raw materials used by the composition are edible in civil society, the safety property is excellent, and the food, health care product or medicine composition is suitable for being taken by patients with diabetes for a long time.

Description

A kind of hypoglycemic food, health products or pharmaceutical composition
Technical field
The invention provides a kind of hypoglycemic food, health products or pharmaceutical composition.
Background technology
The metabolic disease of diabetes to be one group with hyperglycaemia be feature.Hyperglycaemia be then due to defect of insulin secretion or its biological agent impaired, or both have concurrently and cause.Long-standing hyperglycaemia during diabetes, causes various tissue, particularly eye, kidney, heart, blood vessel, neural chronic lesion, dysfunction.
Diabetes B original name, Adult Onset's patients with type Ⅰ DM, how the sequela of 35 ~ 40 years old, accounts for diabetic more than 90%.The ability producing insulin in diabetes B patient body not completely loses, in some patient bodies, insulin even produces too much, but the action effect of insulin is poor, the insulin therefore in patient body is a kind of shortage relatively, can be stimulated the secretion of insulin in body by some oral drugs.But still have some client need use of exogenous insulins to the later stage.
Diabetes B diagnostic criteria in 2010: 1. Glycohemoglobin HbA1c >=6.5%.2. fasting blood-glucose FPG >=7.0mmol/l.Be defined as empty calory at least 8 hours on an empty stomach to take in.3. 2 hours blood glucoses >=11.1mmol/l during oral glucose tolerance test.4. the patient with typical hyperglycaemia or hyperglycaemia crisis symptom, random blood sugar >=11.1mmol/l.When without clear and definite hyperglycaemia, standard 1 ~ 3 should be confirmed by duplicate detection.
Current diabetes mellitus patients pool, research and development treatment can hypoglycemic medicine be that the research of medical circle is popular.
Summary of the invention
The object of the present invention is to provide a kind of effective hypoglycemic food, health products or pharmaceutical composition.
Particularly, the invention provides a kind of hypoglycemic food, health products or pharmaceutical composition, its raw material is made up of the component of following weight proportion:
Snow chrysanthemum 1-5 part, black fruit lyceum 3-7 part, white thorn 5-10 part, folium lycii 5-10 part, safflower 5-15 part, Leaves of Hippophae L 5-15 part.
The present invention studies discovery, after above-mentioned 6 taste material combination are used, the formula of chrysanthemum and black fruit lyceum 2 taste medicine is significantly better than at the equal dosage hypoglycemic drug activity that snows, and white thorn, folium lycii, safflower and Leaves of Hippophae L 4 formula of taste medicine, after the result shows that 6 taste material combinations use by the present invention, create synergistic function.
Further, its raw material is made up of the component of following weight proportion:
Snow chrysanthemum 2-4 part, black fruit lyceum 4-6 part, white thorn 6-9 part, folium lycii 6-9 part, safflower 7-12 part, Leaves of Hippophae L 7-12 part.
Further, its raw material is made up of the component of following weight proportion:
Snow chrysanthemum 3 parts, black fruit lyceum 5 parts, white thorn 7 parts, folium lycii 7 parts, 10 parts, safflower, Leaves of Hippophae L 10 parts.
Snow chrysanthemum:
Compendium of Materia Medica: snow chrysanthemum, former times people calls it can remove wind-heat, kidney-nourishing tonifying yin, and with controlling all public attention orders, its purport is profound and subtle.Bencao Jingshu: snow chrysanthemum peace stomach, Li Wumai, adjusts four limbs, sharp qi and blood person.Record a lot of about the medical value of snow chrysanthemum in successive dynasties pharmacopeia: " the careless warp of the legendary god of farming hundred " that be formed in Qin Han dynasty, its row snow chrysanthemum is that hundred grass are top grade, says: snow chrysanthemum bitter is put down, and head is dazzled and swollen and ache more, and order is for de-, and lacrimation, skin is extremely hungry, takes sharp qi and blood for a long time, makes light of one's life by commiting suicide resistance toly always to prolong life.Well-known doctor's Tao Hongjing says that chrysanthemum cures mainly " wind is dizzy, can make hair not white ".
The traditional Chinese medical science is thought: the Kunlun snow chrysanthemum is cool in nature, has the effects such as wind and heat dispersing, brain nourishing and eyesight improving, removing toxicity for detumescence.And avenge chrysanthemum and have stronger inhibitory action to staphylococcus aureus, corynebacterium diphtheriae and shigella dysenteriae, therefore have obvious curative effects to pneumonia, rhinitis, bronchitis, abscess of throat etc., there is effect of sterilization, antibacterial, anti-inflammatory, preventing cold and chronic enteritis.
Snow chrysanthemum has the high effect of adjustment three, can softening blood vessel, rubbish in removing body, reaches the isohydria of human body, mainly has special curative effect to coronary heart disease, high fat of blood.
Black fruit lyceum:
" Uygur medicine will " is recorded, and Uygur doctor commonly uses lycium ruthenicum fruit and the treatment of root skin urethral calculus, tinea scabies, gingiva bleeding gingival hemorrhage etc., among the people as strengthening by means of tonics, improving eyesight and depressor.
The Tibetan medicine such as the Four-Volume Medical Code, " Jingzhubencao " classical works are recorded black matrimony vine and are used for: treatment cardiopyretic disease, heart disease, irregular menstruation, menelipsis etc. and drug effect is remarkable.Among the peoplely make strengthening by means of tonics, depressor is used.Black fruit lyceum can develop immunitypty, delay senility, tonifying kidney and benefiting sperm, pre-anti-cancer, promote the production of body fluid to quench thirst, improve circulation, blood-enriching tranquillizing, improving water flood, moisten the lung and relieve the cough, delaying senility.Black fruit lyceum can have obvious antifatigue, protects the liver, can also be antitumor, dredging vascellum, step-down, protection Cardiovascular System.
White thorn:
White thorn has higher medical value, is used as medicine with a long history in northwest minority areas, and the husky district people treat the history of existing centuries of catching cold, catch a cold, have a headache and have a stomach upset by white thorn, also how on the books.Ming Dynasty's physician's Li Shizhen (1518-1593 A.D.) once described in Compendium of Material Medica, and " smell is pungent, cold, nontoxic for white thorn.Cure mainly angina pectoris, the swollen purulence of bursting of pain, pain relieving.Treat husband deficient, impotence essence goes out certainly, kidney tonifying gas, beneficial marrow etc. ".Bai Cigu is called eastern Se, husky fluffy rice, popular name western sand cherry.The Northern Wei Dynasty Important Arts for the People's Welfare: “ Dong Se, drought-enduring Salt And Alkali Tolerance, seed is used as medicine, edible ".Supplement to the Herbal: “ Dong Se, taste is sweet flat, nontoxic, and beneficial gas is made light of one's life by commiting suicide, and clothes are not hungry for a long time, hard muscles and bones ".Its fruit and branches and leaves are to be utilized as Chinese herbal medicine, and fruit tool strengthening the spleen and stomach, aid digestion, hypertensive tranquilizing, the effect of inducing sweat, its leaf is among the people is used for the treatment of spasm, neuralgia and cardiac arrhythmia.In Xinjiang, Nitraria sibirica is that medicine is commonly used by the Uygur nationality, claims Acker sheep Plutarch crow to draw lid, has the effects such as strengthening the spleen and stomach, hypotensive, regulating menstruation and activating blood, lactagogue.The local ethnic group diseases such as white bur treatment indigestion and hypertension dizziness, evident in efficacy.Nitraria tangutorum is also conventional folk medicine in anaesthetic, is called craze for Japanese pop culture not lattice.Can strengthening the spleen and stomach, aid digestion, effect of inducing sweat of calming the nerves in addition, cures mainly the diseases such as weakness of the spleen and the stomach, qi-blood deficiency, indigestion and neurasthenia.The present invention's white thorn used is white bur.
Folium lycii:
As far back as the Ming Dynasty, Li Shizhen (1518-1593 A.D.) is mentioned in Compendium of Material Medica " spring adopts folium lycii, name sky essence grass ", the folium lycii tender shoots that namely sky mentioned here essence grass refers in particular to " rhizome with spend reality, tidy up without gurry ".
Lycium leaf tea has and alleviates frigidity, stomach invigorating, liver protecting and kidney invigorating, suppresses pulmonary tuberculosis, eliminates constipation, relieving insomnia, and conditioning low blood pressure, anaemia, treat various eye illness and oral inflammation, and can skin-protecting face nursing.Drink for a long time, to treat the physique cold of insufficiency type, can build up resistance especially, the effect of certain improvement physique can be played.Main containing betaine, carrotene, ascorbic acid, linoleic acid, have the amino acid of tens kinds of needed by human such as asparatate, glutamic acid, methionine, taurine, and be rich in the trace element of the multiple needed by human such as calcium Ca, iron Fe, zinc Zn, selenium Se, vitamin B1, vitamin B2, vitamin C.Calcic height and relation that is hypotensive and reducing blood lipid.Research proves, taking in high calcium can effectively reduce blood pressure, and educating new Lycium leaf tea has obvious hypotensive activity, relevant with containing abundant calcium.Containing abundant folium lycii albumen in Lycium leaf tea.
Safflower:
Compendium of Material Medica records safflower can " invigorate blood circulation, moisturize, pain relieving, loose swollen to stimulate the menstrual flow ".The traditional Chinese medical science is thought pungent, the micro-hardship of safflower taste, warm in nature, the thoughts of returning home and Liver Channel, there is effect of activating blood to promote menstruation, blood stasis removing analgesic, hypotensive, reducing blood lipid, for diseases such as amenorrhoea, dysmenorrhoea, traumatic injury, coronary heart diseases and angina pectoris and hypertension.Safflower becomes the important Chinese medicine of the diseases such as prevention and therapy coronary heart disease, myocardial infarction and cerebral thrombus in modern clinic.Modern pharmacology experiment shows: the pharmacological actions such as safflower can improve the supply of heart and brain blood oxygen, alleviates ischemia injury, anticoagulation, resists myocardial ischemia, Antiaggregating activity on platelet, anti-oxidant, antitumor and anti-inflammatory.
Leaves of Hippophae L:
There is effective Adjust-blood lipid, control the effect of body weight, may be used for prevention and therapy hyperlipidemia.Effect of cholesterolemia and triglycerides can be reduced.
Wherein, described composition is or/and extractive with organic solvent is the formulation of active fraction preparation by the powder of raw material, the water of bulk drug.
Described organic solvent can be selected from ethanol, methyl alcohol, n-butanol, ethyl acetate, chloroform etc.Certainly, in order to guarantee safety, only ethanol can be selected, but, if utilize existing except organic residue technology, also other organic solvents can be adopted.
Further, described formulation is through gastrointestinal administration formulation.
Further, described formulation is medicinal tea, granule, capsule, powder, tablet, pill or oral liquid.
In described formulation, the conventional auxiliary material used can also be comprised, as excipient, adhesive, disintegrant, lubricant, flavouring etc.
Present invention also offers the preparation method of above-mentioned food, health products or pharmaceutical composition, it comprises following operating procedure:
(1) take raw material by proportioning to pulverize;
(2) by the raw material extracting in water after pulverizing, gained water extract carries out preparation.
Extracting in water of the present invention can be temperature leaching, decocting, ultrasonic, microwave or refluxing extraction.
In the embodiment that the present invention one is concrete, adopt the mode of decocting to extract, as decocting 3 times, each 5-15 times water gaging, decocts 0.5-2h at every turn.
Present invention also offers above-mentioned food, health products or the pharmaceutical composition purposes in preparation hypoglycemic food, health products or medicine.
Present invention also offers above-mentioned food, health products or the pharmaceutical composition purposes in preparation prevention, treatment or the food of adjuvant therapy of diabetes, health products or medicine.
The present invention studies discovery, and after being used by each taste material combination, played synergistic function, its hypoglycemic activity is obviously better than other compatibility prescriptions; Meanwhile, the raw material that said composition uses among the people also be edible, security well, is beneficial to diabetes patient's long-term taking.
Detailed description of the invention
The preparation of embodiment 1 present composition
Prescription: avenge chrysanthemum 3g, black fruit lyceum 5g, sting 7g, folium lycii 7g, safflower 10g, Leaves of Hippophae L 10g in vain.
Preparation method: take each medicinal material by prescription, be placed in 50 ~ 60 DEG C of baking ovens and dry pulverizing, merge decoction 3 times, first time adds 12 times of water gagings, soaks 1 hour, heating is boiled 1h and is added 10 times amount soak by water 1h respectively later at every turn, filter, merging filtrate, reduced pressure concentration, add appropriate microcrystalline cellulose, conventionally make capsule.
The preparation of embodiment 2 present composition
Prescription: avenge chrysanthemum 2g, black fruit lyceum 6g, sting 9g, folium lycii 9g, safflower 12g, Leaves of Hippophae L 12g in vain.
Preparation method: take each medicinal material by prescription, be placed in 50 ~ 60 DEG C of baking ovens and dry pulverizing, merge decoction 2 times, first time adds 10 times of water gagings, soak 1 hour, 1.5h is boiled in heating, and second time adds 8 times amount soak by water 1.5h, filters, merging filtrate, reduced pressure concentration, adds appropriate dextrin, conventionally makes granule.
The preparation of embodiment 3 present composition
Prescription: avenge chrysanthemum 4g, black fruit lyceum 4g, sting 6g, folium lycii 6g, safflower 7g, Leaves of Hippophae L 7g in vain.
Preparation method: take each medicinal material by prescription, be placed in 50 ~ 60 DEG C of baking ovens and dry pulverizing, merge decoction 3 times, first time adds 8 times of water gagings, soak 0.5 hour, add 10 times amount soak by water 1h after 0.5h is boiled in heating, third time adds 6 times amount soak by water 0.5h, filters, merging filtrate, reduced pressure concentration, adds appropriate amount of starch, dextrin and dolomol, conventionally makes tablet.
The preparation of embodiment 4 present composition
Prescription: avenge chrysanthemum 3g, black fruit lyceum 5g, sting 7g, folium lycii 7g, safflower 10g, Leaves of Hippophae L 10g in vain.
Preparation method:: take each component dry product respectively, rinse well with trickle, measure moisture respectively, be placed in drying room dry or dry, then be positioned in pulverizer and pulverize respectively, sieve, continue to employ the qualified meal between 10-40 order, qualified for gained meal is dried again, by the water content control of meal within 5%, underproof meal is pulverized again, sieve, continue to employ the qualified meal between 10-40 order, take the meal that each component is qualified by weight percentage, be placed in three-dimensional motion mixer to mix, after infrared sterilizing, sampling inspection, after the assay was approved, carry out being packaged into bag in packaging machine of tea bag, carry out outer packaging again, be finished product.
The drug activity research of embodiment 5 present composition
In the present embodiment test, all select composition prepared by embodiment 1.Dosage is with crude drug gauge.
1. intact animal hypoglycemic experiment
Select healthy adult mouse, by the grouping of the fasting blood sugar level of 4 hours, select 1 control group and 1 dosage group at random.Control group gives the distilled water of same volume, and dosage group gives the high dose concentration present composition (1.6g/kg), continuous 30 days, surveys fasting blood sugar (fasting is with before experiment), compares two treated animal blood glucose values.
2. hyperglycemia model hypoglycemic experiment
2.1 modeling method
Select healthy adult mouse, adapt to after 1 day, get 15 animal fasting 4 hours at random, survey fasting blood-glucose, as this batch of animal basal plasma glucose value.Animal fasting subsequently 24 hours (freely drinking water), injection alloxan (using front Fresh) modeling, mouse 48mg/kg BW.iv.Animal fasting 4 hours after 5 days, surveys blood sugar, and blood glucose value 10-25mmol/L is hyperglycemia model success animal.
2.2 hyperglycemia model animal hypoglycemic experiments
Select hyperglycemia model animal by the grouping of the fasting blood sugar level of 4 hours, select 1 model control group and 3 dosage groups (between group, difference is not more than 1.1mmol/L) at random.Dosage group gives the variable concentrations present composition [large, medium and small 3 dosage groups (1.6,0.8,0.4g/kg)], model control group gives the distilled water of same volume, continuous 30 days, survey fasting blood sugar (fasting is with before experiment), more each treated animal blood glucose value and blood sugar decline percentage.
3. prescription contrast test
Known at present can hypoglycemic Chinese medicine One's name is legion, but how can obtain precise and appropriate, the active good composition of compatibility, be the problem that researcher constantly studies.Except the present composition, inventor also have selected all the other two formulas early stage, and the method for foundation 2.2, the hypoglycemic activity of each composition is compared:
A extract group: snow chrysanthemum 3 parts, black fruit lyceum 5 parts
B extract group: white thorn 7 parts, folium lycii 7 parts, 10 parts, safflower, Leaves of Hippophae L 10 parts
C extract group: snow chrysanthemum 3 parts, black fruit lyceum 5 parts, white thorn 7 parts, folium lycii 7 parts, 10 parts, safflower, Leaves of Hippophae L 10 parts.
Each group of extracting method is all carried out according to embodiment 1.
(3) experimental result
1, capsule of the present invention is on the impact of normal mouse fasting blood-glucose: have no significant effect (P > 0.05) normal mouse fasting blood-glucose, experimental result is in table 1.
Table 1 present composition is on the impact of normal mouse fasting blood-glucose
2, hyperglycemia model hypoglycemic experiment
The result of 2.1 observation modelings: experimental result shows, the blood glucose value of model group mouse is 18.987 ± 4.012, is hyperglycemia model success animal, the results are shown in Table 2 between 10-25mmol/L.
Table 2 alloxan induced diabetes mouse model result
2.2 hyperglycemia model animal hypoglycemic experiments: as shown in Table 3, capsule of the present invention large, medium and small dosage group blood glucose value and blood sugar decline percentage all reduce, compare with model group and have significant statistical significance (P < 0.01), experimental result is in table 3.
Table 3 present composition is on the impact of blood glucose in diabetic mice
Note: * * is p < 0.01 compared with model group
2.3 from table 4 experimental result, although extract A and B all show separately have conspicuousness effect to hypoglycemic activity, but, after each material combination uses by the present invention, drug activity under Isodose is obviously better than extract A, B (p < 0.05), shows that each material combination creates synergistic function.
Table 4 different components is on the impact of blood glucose in diabetic mice
Note: * * is p < 0.01 compared with model group; Δ is p < 0.05 compared with C group
Embodiment 6 infective use:
(1) experiment material
1, given the test agent: make capsule according to method described in the embodiment of the present invention 1,4g crude drug/grain.
2, experimenter selects: select by " health food inspection and assessment technical specification " requirement, each experimenter all turns out to be diabetes B patient through Hospital Physical Examination.
3, experimental design and grouping: standard compliant diabetes B patient is balancedly divided into test-meal group and control group at random, wherein test-meal group 100 example, control group 100 example.
(2) experimental technique
Test-meal group takes the capsule made according to method described in the embodiment of the present invention 1, each 2, and 3 times on the one, control group takes placebo, and instructions of taking, dosage are identical with test-meal group, Continuous Observation 90 days.
(3) experimental result
1, safety indexes
(1) general status sign: test-meal group and control group on pretreatment after, spirit, sleep, diet, stool and urine, blood pressure etc., without significant change, are all acted normally.
(2) blood, urine, feces routine inspection: test-meal group and control group on pretreatment after, blood, urine, feces routine inspection have no significant change.
(3) Liver and kidney function inspection: test-meal group and control group on pretreatment after, Liver and kidney function inspection has no significant change.
(4) Chest X-rays, electrocardiogram, Abdominal B type ultrasonography inspection: on pretreatment, Chest X-rays, electrocardiogram, Abdominal B type ultrasonography inspection are all normal for test-meal group and control group.
2, efficacy measures
(1) fasting blood-glucose:
Compare with before test-meal after the test-meal of test-meal group, fasting blood-glucose declines to some extent, has significant difference (* * P < 0.01); Fasting blood-glucose there was no significant difference before two groups of test-meals, after test-meal, test-meal group fasting blood-glucose fall and decline percentage compare with control group, there is significant difference (* * P < 0.01), and test-meal group evaluates fasting blood-glucose decline percentage > 10%, illustrate that the present composition has the effect significantly reducing fasting blood-glucose, experimental result is in table 5
The change of fasting blood-glucose before and after table 5 test-meal
Note: compare with control group, * * P < 0.01
(2) 2h-plasma glucose:
After the test-meal of test-meal group, postprandial blood sugar compares with before test-meal, has significant difference (* * P < 0.01); Two groups of 2h-plasma glucose there was no significant differences before test-meal, after test-meal, test-meal group postprandial blood sugar fall and decline percentage compare with control group, there is significant difference (* * P < 0.01), and test-meal group evaluates fasting blood-glucose decline percentage > 10%, illustrate that capsule of the present invention has the effect significantly reducing 2h-plasma glucose, experimental result is in table 6.
The change of 2h-plasma glucose before and after table 6 test-meal
Note: compare with control group, * * P < 0.01
Comprehensive above-mentioned test is visible, and after each taste material combination uses by the present invention, played synergistic function, its hypoglycemic activity is obviously better than other compatibility prescriptions; Meanwhile, the raw material that said composition uses among the people also be edible, security well, is beneficial to diabetes patient's long-term taking.

Claims (9)

1. hypoglycemic food, health products or a pharmaceutical composition, is characterized in that: its raw material is made up of the component of following weight proportion:
Snow chrysanthemum 1-5 part, black fruit lyceum 3-7 part, white thorn 5-10 part, folium lycii 5-10 part, safflower 5-15 part, Leaves of Hippophae L 5-15 part.
2. food according to claim 1, health products or pharmaceutical composition, is characterized in that: its raw material is made up of the component of following weight proportion:
Snow chrysanthemum 2-4 part, black fruit lyceum 4-6 part, white thorn 6-9 part, folium lycii 6-9 part, safflower 7-12 part, Leaves of Hippophae L 7-12 part.
3. food according to claim 2, health products or pharmaceutical composition, is characterized in that: its raw material is made up of the component of following weight proportion:
Snow chrysanthemum 3 parts, black fruit lyceum 5 parts, white thorn 7 parts, folium lycii 7 parts, 10 parts, safflower, Leaves of Hippophae L 10 parts.
4. the food according to claims 1 to 3 any one, health products or pharmaceutical composition, is characterized in that: it is or/and extractive with organic solvent is the formulation of active fraction preparation by the powder of raw material, the water of bulk drug.
5. formulation according to claim 4, is characterized in that: described formulation is through gastrointestinal administration formulation.
6. the formulation according to claim 4 or 5, is characterized in that: described formulation is medicinal tea, granule, capsule, powder, tablet, pill or oral liquid.
7. the preparation method of food, health products or pharmaceutical composition described in claim 1-6 any one, is characterized in that: it comprises following operating procedure:
(1) take raw material by proportioning to pulverize;
(2) by the raw material extracting in water after pulverizing, gained water extract carries out preparation.
8. the purposes in preparation hypoglycemic food, health products or medicine of food, health products or pharmaceutical composition described in claim 1 ~ 6 any one.
9. the purposes in preparation prevention, treatment or the food of adjuvant therapy of diabetes, health products or medicine of food, health products or pharmaceutical composition described in claim 1 ~ 6 any one.
CN201410542588.3A 2014-09-29 2014-09-29 A kind of hypoglycemic food, health products or pharmaceutical composition Expired - Fee Related CN104256618B (en)

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CN104997937A (en) * 2015-07-21 2015-10-28 中国科学院西北高原生物研究所 Hypoglycemic food or health-care product or medicine composition containing Chinese wolfberry fruits
CN107484854A (en) * 2016-06-12 2017-12-19 李忱 A kind of white thorn tea and preparation method thereof

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CN1416731A (en) * 2001-11-01 2003-05-14 中国科学院西北高原生物研究所 Blood fat-reducing anti-fatigue health food composition
CN103168890A (en) * 2013-04-08 2013-06-26 瓜州亿得生物科技有限公司 Medlar coreopsis tinctoria flower tea
CN103340263A (en) * 2013-06-23 2013-10-09 乌鲁木齐市海缘承乾商贸有限公司 Sanvitalia procumbens herbal tea and preparation method thereof
KR101377059B1 (en) * 2012-11-16 2014-04-01 김재현 Manufacturing method of enhanced flavor tea using dried chrysanthemum flower and dried wolfberry
CN103977157A (en) * 2014-05-17 2014-08-13 苟春虎 Lycium ruthenicum eyesight-improving eye-protecting tea

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Publication number Priority date Publication date Assignee Title
CN1416731A (en) * 2001-11-01 2003-05-14 中国科学院西北高原生物研究所 Blood fat-reducing anti-fatigue health food composition
KR101377059B1 (en) * 2012-11-16 2014-04-01 김재현 Manufacturing method of enhanced flavor tea using dried chrysanthemum flower and dried wolfberry
CN103168890A (en) * 2013-04-08 2013-06-26 瓜州亿得生物科技有限公司 Medlar coreopsis tinctoria flower tea
CN103340263A (en) * 2013-06-23 2013-10-09 乌鲁木齐市海缘承乾商贸有限公司 Sanvitalia procumbens herbal tea and preparation method thereof
CN103977157A (en) * 2014-05-17 2014-08-13 苟春虎 Lycium ruthenicum eyesight-improving eye-protecting tea

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104997937A (en) * 2015-07-21 2015-10-28 中国科学院西北高原生物研究所 Hypoglycemic food or health-care product or medicine composition containing Chinese wolfberry fruits
CN104997937B (en) * 2015-07-21 2019-11-29 中国科学院西北高原生物研究所 A kind of blood sugar reducing food containing fructus lycii, health care product or pharmaceutical composition
CN107484854A (en) * 2016-06-12 2017-12-19 李忱 A kind of white thorn tea and preparation method thereof

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