CN104997937B - A kind of blood sugar reducing food containing fructus lycii, health care product or pharmaceutical composition - Google Patents
A kind of blood sugar reducing food containing fructus lycii, health care product or pharmaceutical composition Download PDFInfo
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- CN104997937B CN104997937B CN201510445858.3A CN201510445858A CN104997937B CN 104997937 B CN104997937 B CN 104997937B CN 201510445858 A CN201510445858 A CN 201510445858A CN 104997937 B CN104997937 B CN 104997937B
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Abstract
The present invention provides a kind of blood sugar reducing food containing fructus lycii, health care product or pharmaceutical composition, raw material is grouped as by the group of following weight proportion: 1~10 part of fructus lycii, 10~20 parts of Hubei Chinese flowering crabapple leaf.The research of the invention finds that having played synergistic function, hypoglycemic activity gets a promotion, better than the exclusive use of the two after fructus lycii and Hubei Chinese flowering crabapple leaf are applied in combination.Meanwhile the present invention has further been found that (5: 15) after combining fructus lycii under specific proportion with Hubei Chinese flowering crabapple leaf, effect of lowering blood sugar is be more good, better than other proportions (1: 10,10: 10) in experiment.Based on the studies above, the present invention provides a kind of new hypoglycemic compositions, provide new selection for clinical application and health therapy.
Description
Technical field
The invention belongs to field of health care products, and in particular to a kind of blood sugar reducing food containing fructus lycii, health care product or drug
Composition.
Technical background
According to statistics, the number of patients of China's diabetes has had reached 92,400,000 at present, occupies (Yang W, et first of the whole world
Al.N Engl J Med, 2010,362 (12): 1090-1101).Diabetes mellitus in China medical expense is up to 173,400,000,000 yuan every year, sugar
Urine disease caused by direct medical expenses accounted for Chinese medical total expenses 13% (Alcorn T, et al.Lancet,
2012,379 (9833): 2227-2228).It it can be seen that diabetes not only seriously endanger the health of the people, but also is national band
Carry out heavy financial burden.Thus, prevention and treatment diabetes are very urgent.
Fructus lycii is plant of Solanaceae China fructus lycii Lycium chinense Mill. or lycium barbarum Lycium
The ripening fruits of barbarum L., can be nourishing liver and kidney, strengthening the essence blood-nourishing, and improving eyesight disappears screen, and moistening lung to arrest cough cures mainly the kidney deficiency atrophic debility of bones, impotence
Spermatorrhea, long infertility, senilism early ageing, poliosis, blood deficiency chlorosis, postpartum cream is few, and mesh is secretly unknown, interior external opculopathy eye, Heat Diabetes,
The hot hectic fever due to yin of labor, tuberculosis cough, dry cough lack the diseases such as phlegm.
The tender leaf or old that Hubei Chinese flowering crabapple leaf is rosaceous plant Hubei Chinese flowering crabapple Malus hupehensis (Pamp.) Rehd.
Leaf, tender leaf make tea can disperse accumulationization it is stagnant, stomach function regulating invigorating the spleen, staple food product stagnate；Indigestion；Dysentery；Infantile malnutrition due to digestive disturbances or intestinalparasites.Modern pharmacological research hair
Existing, Hubei Chinese flowering crabapple leaf has certain hypoglycemic effect.
It yet there are no the relevant report that fructus lycii and Hubei Chinese flowering crabapple leaf are used in combination.
Summary of the invention
The purpose of the present invention is to provide a kind of hypoglycemic compositions.The present invention also provides the preparation sides of the composition
Method and purposes.
Specifically, the present invention provides a kind of hypoglycemic food, health care product or pharmaceutical composition, raw material by weighing as follows
The group of amount proportion is grouped as:
1~10 part of fructus lycii, 10~20 parts of Hubei Chinese flowering crabapple leaf.
Further, raw material is grouped as by the group of following weight proportion:
5~10 parts of fructus lycii, 15~20 parts of Hubei Chinese flowering crabapple leaf.
Further, raw material is grouped as by the group of following weight proportion:
5 parts of fructus lycii, 15 parts of Hubei Chinese flowering crabapple leaf.
Each raw material weight proportioning of soup processed of the present invention, is calculated with dry product, if fresh goods or aqueous product, can change according to water content
It calculates.
Wherein, the composition is orally to take dosage form.
Further, the dosage form of orally taking is selected from granule, powder, medicinal tea, pill, tablet or capsule.
The present invention also provides the preparation methods of above-mentioned food, health care product or pharmaceutical composition, it includes following operation step
It is rapid:
Raw material is taken according to the ratio；
After mixing by raw material, extracting in water, extracting solution be added appropriate amount of auxiliary materials or complementary ingredient be prepared food,
Health care product or pharmaceutical composition.
The present invention also provides another preparation methods of above-mentioned food, health care product or pharmaceutical composition, it includes as follows
Operating procedure:
Raw material is taken according to the ratio；
After mixing by raw material, alcohol water is double mentions, extract is added appropriate amount of auxiliary materials or complementary ingredient be prepared food,
Health care product or pharmaceutical composition.
The present invention also provides above-mentioned compositions to prepare the purposes in hypoglycemic drug, health care product or food.
Further, the drug, health care product or food are preventions or treat I type, type-2 diabetes mellitus or/and diabetes simultaneously
Send out drug, health care product or the food of disease.
The research of the invention finds that synergistic function has been played after fructus lycii and Hubei Chinese flowering crabapple leaf will be applied in combination, drop
Blood glucose activity gets a promotion, better than the exclusive use of the two.Meanwhile the present invention has further been found that fructus lycii and Hu Beihai
After Chinese bush cherry leaf combines under specific proportion (5: 15), effect of lowering blood sugar is be more good, better than in experiment other proportion (1: 10,
10:10).Based on the studies above, the present invention provides a kind of new hypoglycemic compositions, provide for clinical application and health therapy
New selection.
Specific embodiment
Embodiment 1: the preparation of the present composition
Fructus lycii and Hubei Chinese flowering crabapple leaf are taken, the two weight ratio is 5: 15 (calculating by dry product), after mixing, adds water to cook and mentions
It takes 2 times, each 30min, combined extract is to get decoction.
Embodiment 2: the preparation of the present composition
Fructus lycii and Hubei Chinese flowering crabapple leaf are taken, the two weight ratio is 1: 10 (calculating by dry product), after mixing, successively with 70%
V/v ethyl alcohol, water refluxing extraction 2 times, each 30min, ethanol extract merges after recycling ethyl alcohol with Aqueous extracts, is concentrated, and is added suitable
Amount dextrin and microcrystalline cellulose prepare granule.
Embodiment 3: the preparation of the present composition
Fructus lycii and Hubei Chinese flowering crabapple leaf are taken, the two weight ratio is 10: 20 (calculating by dry product), and dry, crushing mixes,
Appropriate microcrystalline cellulose is added, after mixing, prepares powder.
Embodiment 4: the preparation of the present composition
Fructus lycii and Hubei Chinese flowering crabapple leaf are taken, the two weight ratio is 5: 15 (calculating by dry product), after dry, is mixed, preparation
Tea bag.
The experiment of 5 present composition hypoglycemic effect of embodiment
1) experimental drug:
A group: taking fructus lycii and the total 200g of Hubei Chinese flowering crabapple leaf, and the two weight ratio is 5: 15 (calculating by dry product), after mixing,
Extraction 2 times, each 30min is added water to cook, combined extract is concentrated into 200ml, and gained extractum A is spare.
B group: taking fructus lycii and the total 200g of Hubei Chinese flowering crabapple leaf, and the two weight ratio is 1: 10 (calculating by dry product), after mixing,
Extraction 2 times, each 30min is added water to cook, combined extract is concentrated into 200ml, and gained medicinal extract B is spare.
C group: taking fructus lycii and the total 200g of Hubei Chinese flowering crabapple leaf, and the two weight ratio is 10: 10 (calculating by dry product), mixing
Afterwards, extraction 2 times, each 30min is added water to cook, combined extract is concentrated into 200ml, and gained medicinal extract C is spare.
D group: taking fructus lycii 200g, adds water to cook extraction 2 times, each 30min, combined extract is concentrated into 200ml, institute
It is spare to obtain medicinal extract D.
E group: taking Hubei Chinese flowering crabapple leaf 200g, adds water to cook extraction 2 times, each 30min, combined extract is concentrated into
200ml, gained medicinal extract E are spare.
For dosage based on rat body weight, stomach-filling low dosage, middle dosage, high dose are respectively 1ml/kg, 2ml/kg, 4ml/kg
(medicinal extract meter).
2) animal: four week old Kunming rats, male, regular grade, 135g are provided by Gansu Chinese of Traditional Chinese Medicine.In in laboratory
It is placed in raise in mouse cage and is tested (10, every cage, 22 ± 1 DEG C of temperature, humidity 42% ± 2%) after a week.Grouping: respectively
For blank group (intravenous injection the non-modeling of citrate buffer solution, ultrapure water stomach-filling), and model group (tail vein injection STZ modeling, it is ultrapure
Water stomach-filling), positive drug group (tail vein injection STZ modeling, glibenclamide 20mg/kg stomach-filling), low dose of pharmaceutical composition of the present invention
Amount group A1, B1, C1 (tail vein injection STZ modeling, pharmaceutical composition stomach-filling 1ml/kg of the present invention), in pharmaceutical composition of the present invention
Dosage group A2, B2, C2 (tail vein injection STZ modeling, pharmaceutical composition stomach-filling 2ml/kg of the present invention), pharmaceutical composition of the present invention
High dose group A3, B3, C3 (tail vein injection STZ modeling, pharmaceutical composition stomach-filling 4ml/kg of the present invention).Modeling method: in advance
Fasting 16h then carries out STZ (citrate buffer solution preparation) tail vein injection 60mg/kg to it, after injection, surveys it within 72 hours
Blood glucose, testing model success or not.
3) experimentation: taking healthy SD rat, random to be grouped, and is divided into blank group, model group, positive drug group and low, in, it is high
Dosage group.Distilled water is given in blank group and the daily stomach-filling of model group；The daily stomach-filling of positive drug group is given glibenclamide 1 time；To by
The examination daily stomach-filling of medicine group is given pharmaceutical composition 1 time of the present invention, and each group continuously gives 28d, and 12h surveys blood after the last administration
Sugar, and record.
4) pharmaceutical composition of the present invention reduces the result for suffering from the intracorporal blood glucose of diabetes rat
Influence (Mean ± SD) of the pharmaceutical composition of the present invention of table 1 to the STZ rat blood sugar induced
Note: compared with normal groupaP < 0.05,aaP < 0.01；Compared with model groupbP < 0.05,bbP < 0.01；With A group
Same dose group is comparedcP < 0.05,ccP < 0.01
As shown in Table 1, pharmaceutical composition each group of the present invention has to reduce and make to the blood glucose of the STZ diabetes rat induced
With, and be in certain dose-effect relationship, there is significant difference (p < 0.05 or 0.01) with model group.
Meanwhile A, B of the present invention, component C do not have 3 kinds of different ratios, three it was found that, A group is more excellent compared with B, C group (with phase
The p < 0.05 compared with dosage A group), therefore, the preferred A group proportion of the present invention is optimal proportion.
In addition, the fructus lycii or Hubei Chinese flowering crabapple leaf of same concentrations is used alone, although having in low dosage reduces blood glucose
Trend, but hypoglycemic effect is unobvious, and model group comparative significant difference (p > 0.05), hypoglycemic activity is obviously not
And the combination of the two has played synergistic function after this also turns out that fructus lycii and Hubei Chinese flowering crabapple leaf are applied in combination the present invention,
Hypoglycemic activity gets a promotion.
Claims (7)
1. a kind of hypoglycemic pharmaceutical composition, it is characterised in that: its raw material is grouped as by the group of following weight proportion:
5 parts of fructus lycii, 15 parts of Hubei Chinese flowering crabapple leaf.
2. pharmaceutical composition according to claim 1, it is characterised in that: the composition is orally to take dosage form.
3. pharmaceutical composition according to claim 2, it is characterised in that: the dosage form of orally taking is selected from granule, dissipates
Agent, medicinal tea, pill, tablet or capsule.
4. the preparation method of claim 1 described pharmaceutical composition, it is characterised in that: it includes following operating procedure:
(1) raw material is taken according to the ratio；
(2) after mixing by raw material, extracting in water, appropriate amount of auxiliary materials is added in extracting solution or medicine group is prepared in complementary ingredient
Close object.
5. the preparation method of claim 1 described pharmaceutical composition, it is characterised in that: it includes following operating procedure:
(1) raw material is taken according to the ratio；
(2) after mixing by raw material, alcohol water is double mentions, and appropriate amount of auxiliary materials is added in extract or medicine group is prepared in complementary ingredient
Close object.
6. composition described in claims 1 to 3 any one is preparing the purposes in hypoglycemic drug.
7. purposes according to claim 6, it is characterised in that: the drug is prevention or treatment I type, type-2 diabetes mellitus
Or/and the drug of diabetic complication.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510445858.3A CN104997937B (en) | 2015-07-21 | 2015-07-21 | A kind of blood sugar reducing food containing fructus lycii, health care product or pharmaceutical composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510445858.3A CN104997937B (en) | 2015-07-21 | 2015-07-21 | A kind of blood sugar reducing food containing fructus lycii, health care product or pharmaceutical composition |
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| CN104997937A CN104997937A (en) | 2015-10-28 |
| CN104997937B true CN104997937B (en) | 2019-11-29 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104256618A (en) * | 2014-09-29 | 2015-01-07 | 青海唐古特生物科技有限公司 | Food, health care product or medicine composition with blood sugar reduction function |
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2015
- 2015-07-21 CN CN201510445858.3A patent/CN104997937B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104256618A (en) * | 2014-09-29 | 2015-01-07 | 青海唐古特生物科技有限公司 | Food, health care product or medicine composition with blood sugar reduction function |
Non-Patent Citations (2)
| Title |
|---|
| 枸杞降血糖作用的药效学研究;谭淑敏;《南方医科大学学报》;20081231;第28卷;第2104页4讨论 * |
| 湖北海棠叶治疗2型糖尿病疗效观察;公丕军等;《实用糖尿病杂志》;20111231;第7卷(第4期);第35页3讨论项下 * |
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