CN104306553B - A kind of food of reducing blood lipid, health care product or pharmaceutical composition - Google Patents

A kind of food of reducing blood lipid, health care product or pharmaceutical composition Download PDF

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CN104306553B
CN104306553B CN201410542503.1A CN201410542503A CN104306553B CN 104306553 B CN104306553 B CN 104306553B CN 201410542503 A CN201410542503 A CN 201410542503A CN 104306553 B CN104306553 B CN 104306553B
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parts
health care
care product
pharmaceutical composition
raw material
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CN104306553A (en
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胡娜
周武
索有瑞
尤志海
舒红辉
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QINGHAI TANGGUTE BIOTECHNOLOGY Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction

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Abstract

The present invention provides a kind of food of reducing blood lipid, health care product or pharmaceutical composition, raw material is grouped as by the group of following weight proportion: 3-7 parts of black fruit fructus lycii of 1-5 parts of snow chrysanthemum 5-15 parts of white thorn 5-10 parts of wolfberry leaf 5-15 parts of Leaves of Hippophae L of 5-15 parts of safflower.The research of the invention finds that having played synergistic function for after each taste material combination use, effect for reducing blood fat is substantially better than other compatibility prescriptions；Meanwhile the raw material that uses of the composition it is civil be also edible, good security, be conducive to diabetes patient and take for a long time.

Description

A kind of food of reducing blood lipid, health care product or pharmaceutical composition
Technical field
The present invention provides a kind of food of reducing blood lipid, health care product or pharmaceutical compositions.
Background technique
Hyperlipidemia refers to that blood lipid level is excessively high, can directly cause some diseases for seriously endangering human health, such as artery Atherosis, coronary heart disease, pancreatitis etc..Hyperlipidemia can be divided into primary and secondary two class.Primary and congenital and something lost Pass it is related, be due to single-gene defect or polygenes defect, make participate in lipoprotein transhipment and metabolism receptor, enzyme or apolipoprotein Caused by abnormal, or caused due to environmental factor (diet, nutrition, drug) and by unknown mechanism.It is secondary to mostly occur in generation Thank sexual disorder disease (diabetes, hypertension, myxoedema, hypothyroidism, obesity, liver and kidney disease, adrenal cortex Hyperfunction), or with the other factors age, gender, season, drink, smoke, diet, physical exertion, stress, mood it is living It is dynamic etc. related.
Current hyperlipidemia patient is numerous, research and development treatment can reducing blood lipid drug be medical field research hot topic.
Summary of the invention
The purpose of the present invention is to provide food, health care product or the pharmaceutical compositions of a kind of effective reducing blood lipid.
Specifically, the present invention provides a kind of food of reducing blood lipid, health care product or pharmaceutical compositions, and raw material by weighing as follows The group of amount proportion is grouped as:
3-7 parts of black fruit fructus lycii of 1-5 parts of snow chrysanthemum 5-15 parts of white thorn 5-10 parts of wolfberry leaf 5-15 parts of Leaves of Hippophae L of 5-15 parts of safflower.
Further, raw material is grouped as by the group of following weight proportion:
4-6 parts of black fruit fructus lycii of 2-4 parts of snow chrysanthemum 8-12 parts of white thorn 6-9 parts of wolfberry leaf 8-12 parts of Leaves of Hippophae L of 8-12 parts of safflower.
Closer, raw material is grouped as by the group of following weight proportion:
3 parts of snow chrysanthemum, 5 parts of black fruit fructus lycii, 10 parts of 7 parts of wolfberry leaf, 10 parts of Leaves of Hippophae L of 10 parts of safflowers of white thorn.
Snow chrysanthemum:
Compendium of Materia Medica: snow chrysanthemum, former times people calls it can be except wind-heat, and kidney-nourishing tonifying yin, with all public attention mesh are controlled, purport is profound and subtle.Book on Chinese herbal medicine warp Dredge: snow chrysanthemum pacifies stomach, and Li Wumai adjusts four limbs, sharp qi and blood person.Book on Chinese herbal medicine is newly organized: snow chrysanthemum, smell is gently clear, and function is also very slow, must suitable long term usage Begin effect, can not blame with nearly function, and only for mesh pain suddenly with it, success is very fast, remaining, all can take effect in the slow beginning.The need for doing tea tender tea leaves are taken again, Think improving eyesight." Xinhua's book on Chinese herbal medicine outline ": herb: it is sweet in flavor, it is mild-natured.There is clearing heat and detoxicating, dampness elimination function.For acute and chronic dysentery Disease, red eye, swell pain, hygropyretic dysentery, dysentery etc..Medical value record in successive dynasties pharmacopeia about snow chrysanthemum is a lot of: mostly in Qin Han dynasty " legendary god of farming hundred grass warp ", column snow chrysanthemum is hundred careless top grades, and say: snow chrysanthemum bitter is flat, and head dazzles swelling and pain, and mesh is intended to take off, lacrimation, and skin is dead Famine, long term usage benefit qi and blood, resistance to old macrobiosis of making light of one's life by commiting suicide.Name doctor's Tao Hongjing says that chrysanthemum cures mainly " wind is dizzy, and hair can be enabled not white ".
Chinese medicine thinks: coreopsis tinctoria is cool in nature, there is dispelling wind and heat, brain nourishing and eyesight improving, removing toxicity for detumescence and other effects.And snow chrysanthemum is to gold Staphylococcus aureus, corynebacterium diphtheriae and shigella dysenteriae have stronger inhibiting effect, therefore to pneumonia, rhinitis, bronchitis, throat Swelling and pain etc. have obvious curative effects, have effects that sterilization, antibacterial, anti-inflammatory, preventing cold and chronic enteritis.
Snow chrysanthemum has the function of that adjusting three is high, can soften blood vessel, removal internal rubbish, reach the isohydria of human body, Mainly there is special curative effect to coronary heart disease, hyperlipidemia.
Black fruit fructus lycii:
" Uygur medicine will " is recorded, and Uygur doctor often uses lycium ruthenicum fruit and root skin to treat urethral calculus, tinea scabies, tooth Oulorrhagia etc., it is civil to be used as strengthening by means of tonics, improving eyesight and depressor.
The Tibetan medicines classical works such as the Four-Volume Medical Code, " Jingzhubencao " record lycium ruthenicum be used for: treatment cardiopyretic disease, heart disease, Irregular menstruation, menopause etc. and drug effect is significant.It is civil to make strengthening by means of tonics, it is depressured medicinal.Black fruit fructus lycii can be enhanced immunity, delay Aging, tonifying kidney and benefiting sperm, pre- anti-cancer promote the production of body fluid to quench thirst, improve circulation, and blood-enriching tranquillizing improves sleep, moistening lung to arrest cough, delaying senility. Black fruit fructus lycii can have apparent antifatigue, liver protection, moreover it is possible to which Cardiovascular System is protected in antitumor, dredging vascellum, decompression.
White thorn:
White thorn medical value with higher, is used as medicine with a long history in northwest minority areas, the white thorn of the husky area people Cold, flu, the history had a headache and have a stomach upset existing centuries are treated, it is also how on the books.Ming Dynasty's physician's Li Shizhen (1518-1593 A.D.) once existed It is described in Compendium of Material Medica, " smell is pungent, cold, nontoxic for white thorn.Cure mainly the swollen routed purulence of angina pectoris, pain, analgesic.It is deficient to treat husband, impotence Essence goes out certainly, kidney tonifying gas, benefiting quintessence etc. ".White thorn ancient name Wei Dong Se, husky fluffy rice, popular name western sand cherry.Northern Wei Dynasty Important Arts for the People's Welfare: " east Se, drought-enduring saline-alkali tolerant, seed is used as medicine, edible ".Supplement to the Herbal: " Dong Se, sweet taste, nontoxic, QI invigorating is made light of one's life by commiting suicide, and long term usage is not hungry, Hard muscles and bones ".To be utilized as Chinese herbal medicine, fruit has strengthening the spleen and stomach, aid digestion, hypertensive tranquilizing, the function of inducing diaphoresis for its fruit and branches and leaves Effect, leaf are civil for treating spasm, neuralgia and cardiac arrhythmia.In Xinjiang, Nitraria sibirica is that medicine is commonly used by the Uygur nationality Object claims Acker sheep Plutarch crow to draw lid, has strengthening the spleen and stomach, blood pressure lowering, regulating menstruation and activating blood, stimulating milk secretion and other effects.Local ethnic group is with white Bur treats the diseases such as indigestion and hypertension dizziness, significant in efficacy.Nitraria tangutorum is also common civil in anaesthetic Drug, referred to as craze for Japanese pop culture not lattice.Can strengthening the spleen and stomach, aid digestion, the effect of there are also tranquilizing the mind inducing diaphoresis, cure mainly weakness of the spleen and the stomach, qi-blood deficiency, disappear Change the diseases such as bad and neurasthenia.White thorn used in the present invention is white bur.
Wolfberry leaf:
Early in the Ming Dynasty, Li Shizhen (1518-1593 A.D.) mentions " spring adopts wolfberry leaf, name day essence grass ", day essence mentioned here in Compendium of Material Medica Grass refers in particular to the wolfberry leaf tender shoots of " rhizome and spend reality, tidy up no gurry ".
Lycium leaf tea, which has, mitigates frigidity, stomach invigorating, and liver protecting and kidney invigorating inhibits pulmonary tuberculosis, eliminates constipation, and relieving insomnia is adjusted Low blood pressure, anaemia are managed, treats various eye illnesses and oral inflammation, and can be with skin-protecting face nursing.Long-term drinking, even more can be with treatment Deficient cold constitution, resistance building, can play the role of certain improvement constitution.Mainly contain glycine betaine, carrotene, Vitamin C Acid, linoleic acid, ten several amino acid needed by human such as have asparatate, glutamic acid, methionine, taurine, and it is rich in calcium A variety of the essential trace elements of the human bodys such as Ca, iron Fe, zinc Zn, selenium Se, vitamin B1, vitamin B2, vitamin C.Calcic height with The relationship of blood pressure lowering and reducing blood lipid.Research has shown that blood pressure can be effectively reduced in intake high calcium, and educating new Lycium leaf tea has apparent drop blood Pressure effect, it is related with containing calcium abundant.Fructus lycii leaf protein rich in Lycium leaf tea.
Safflower:
Compendium of Material Medica records safflower and " can invigorate blood circulation, moisturize, relieve pain, dissipate swollen promoting menstruation ".Safflower acrid flavour, micro- is thought in Chinese medicine Bitter, warm-natured, return heart and Liver Channel have effects that blood circulation, removing blood stasis and acesodyne, lowering blood pressure and blood fat, for amenorrhoea, dysmenorrhea, fall Beat the diseases such as damage, coronary heart diseases and angina pectoris and hypertension.Safflower becomes in modern clinic prevents and treats coronary heart disease, cardiac muscle The important Chinese medicine of the diseases such as infarct and cerebral thrombosis.Modern pharmacology experiment shows: safflower can improve heart and brain blood oxygen supply, mitigate ischemic Property damage anticoagulation, resists myocardial ischemia, inhibits platelet aggregation, is anti-oxidant, antitumor and anti-inflammatory etc. pharmacological actions.
Leaves of Hippophae L:
Have the function of effective Adjust-blood lipid, control weight, can be used for preventing and treating hyperlipidemia.Blood can be reduced The effect of cholesterol and triglycerides.
Wherein, it is to be prepared by the powder of raw material, the water of bulk pharmaceutical chemicals or/and extractive with organic solvent for active constituent Dosage form.
The organic solvent can be selected from ethyl alcohol, methanol, n-butanol, ethyl acetate, chloroform etc..Certainly, pacify to ensure Quan Xing can only select ethyl alcohol, still, if removing organic residue technology using existing, other organic solvents also can be used.
Further, the dosage form is through gastrointestinal administration dosage form.
For example, the dosage form is medicinal tea, granule, capsule, powder, tablet, pill or oral solution.In the dosage form, It can also include conventional use of auxiliary material, such as excipient, adhesive, disintegrating agent, lubricant, corrigent.
The present invention also provides the preparation methods of above-mentioned food, health care product or pharmaceutical composition, it includes following operation step It is rapid:
(1) raw material crushing is weighed according to the ratio；
(2) by smashed raw material extracting in water, gained water extract carries out preparation.
Extracting in water of the present invention can be warm leaching, decocting, ultrasound or refluxing extraction.
The present invention also provides above-mentioned food, health care product or pharmaceutical composition the preparation food of reducing blood lipid, health care product or Purposes in drug.
The present invention also provides above-mentioned food, health care product or pharmaceutical compositions to prevent, treat or assist in the treatment of height in preparation Purposes in the food of pionemia, health care product or drug.
Wherein, the food, health care product or pharmaceutical composition are to reduce TC, TG, LDL-C level, improve HDL-C level Food, health care product or drug.
The research of the invention finds that having played synergistic function, effect for reducing blood fat is bright for after each taste material combination use It is aobvious to be better than other compatibility prescriptions；Meanwhile the raw material that uses of the composition it is civil be also edible, good security, be conducive to glycosuria Patient takes for a long time.
Specific embodiment
The preparation of 1 present composition of embodiment
Prescription: the white thorn 10g wolfberry leaf 7g safflower 10g Leaves of Hippophae L 10g of snow chrysanthemum 3g black fruit fructus lycii 5g.
Preparation method: weighing each medicinal material by prescription, is placed in dries pulverizing in 50~60 DEG C of baking ovens, merges and decocts 3 times, and first Secondary plus 12 times of amount water impregnate 1 hour, and heating is separately added into 10 times of amount water decoction 1h after boiling 1h every time, and filtering merges filter Liquid is concentrated under reduced pressure, appropriate microcrystalline cellulose is added, capsule is conventionally made.
The preparation of 2 present composition of embodiment
Prescription: the white thorn 12g wolfberry leaf 9g safflower 12g Leaves of Hippophae L 12g of snow chrysanthemum 2g black fruit fructus lycii 6g.
Preparation method: weighing each medicinal material by prescription, is placed in dries pulverizing in 50~60 DEG C of baking ovens, merges and decocts 2 times, and first 1.5h is boiled in secondary plus 10 times of amount water, immersion 1 hour, heating, and second of addition, 8 times of amount water decoct 1.5h, filters, merging filtrate, It is concentrated under reduced pressure, appropriate dextrin is added, granule is conventionally made.
The preparation of 3 present composition of embodiment
Prescription: the white thorn 8g wolfberry leaf 6g safflower 8g Leaves of Hippophae L 8g of snow chrysanthemum 4g black fruit fructus lycii 4g.
Preparation method: weighing each medicinal material by prescription, is placed in dries pulverizing in 50~60 DEG C of baking ovens, merges and decocts 3 times, and first Secondary plus 8 times of amount water impregnate 0.5 hour, and 10 times of amount water of addition decoct 1h, third time plus 6 times of amount decoctings after 0.5h is boiled in heating 0.5h is boiled, is filtered, merging filtrate, is concentrated under reduced pressure, appropriate amount of starch, dextrin and magnesium stearate is added, piece is conventionally made Agent.
The preparation of 4 present composition of embodiment
Prescription: the white thorn 5g wolfberry leaf 5g safflower 5g Leaves of Hippophae L 5g of snow chrysanthemum 5g black fruit fructus lycii 3g.
Preparation method: each component dry product is weighed respectively, is rinsed well with water drenching, measures moisture respectively, is placed in drying chamber and dries It does or dries, be then placed into pulverizer and crushed respectively, be sieved, continue to employ the qualified coarse powder between 10-40 mesh, by gained Qualified coarse powder is dried again, and the water content of coarse powder is controlled within 5%, underproof coarse powder is crushed again, mistake Sieve, continues to employ the qualified coarse powder between 10-40 mesh, weighs the coarse powder of each component qualification by weight percentage, and it is mixed to be placed in three-dimensional motion It is mixed in conjunction machine, after infrared sterilizing, sampling inspection carries out being packaged into bag in packaging machine of tea bag after the assay was approved, Outer packaging, as finished product are carried out again.
The drug activity of 5 present composition of embodiment is studied
In the present embodiment test, the composition of the preparation of embodiment 1 is selected.Dosage is with crude drug meter.
One, reducing blood lipid effect experiment
1. materials and methods
1.1 material
Experimental animal takes Wister rat, and rat body weight 160-190g is male, and 100.
1.2 animal packets and method
100 rats, are divided into 2 groups, and Normal group gives normal diet, remaining animal gives high lipid food.Feeding high in fat The preparation of material: refined lard 15%, cholesterol 2% (sterling), sucrose 2% is added in conventional feed 81%.Animal free water. 15th day high in fat group of animal orbital venous plexus takes blood, measures serum total cholesterol and triglycerides, is divided at random according to blood lipid level For hyperlipidemia model group, pravastatin sodium group (western medicine group), of the present invention group.Physiological saline, rouge are given in Normal group stomach-filling Model group gives high lipid food and physiological saline, remaining each administration group gives high lipid food and relative medicine, Chinese medicine of the present invention Composition group is given be equivalent to crude drug amount 1.5g/kg weight respectively, and pravastatin sodium group is administered by 3.6mg/kg weight.Continuously After administration 40 days, animal is put to death, abdominal vein takes blood, and total cholesterol, triglycerides, highly dense is measured on automatic clinical chemistry analyzer Spend the indexs such as lipoprotein cholesterol, concentration of low density lipoprotein cholesterol.
In addition, the composition of different prescriptions is chosen, influence of the more different prescription compages objects to rat lipid-lowering effect:
Extract A: 3 parts of snow chrysanthemum+white 10 parts of thorn
Extract B: 10 parts of 10 parts+Leaves of Hippophae L of 5 parts+wolfberry leaf of black fruit fructus lycii, 7 parts+safflower
The extracting method of said extracted object is the same as embodiment 1.
2. experimental result
The serum TC (total cholesterol) of each group rat, TG (triglycerides), HDL-C (high-density lipoprotein cholesterol) and LDL-C (low density lipoprotein cholesterol) changes of contents is shown in Table 1
Influence (mean ± SD) (mmol/L) of 1 Chinese medicinal compound extract of table to rat fat
Compared with Normal group, Δ P < 0.05；Δ Δ P < 0.01；Compared with hyperlipidemia model group, * P < 0.05；**P < 0.01.
The result shows that hyperlipidemia model group is significantly improved compared with Normal group TC, TG, LDL-C level, HDL-C is significantly reduced, Prompt hyperlipidemia rats modeling success.The traditional chinese medicine composition of the invention group can significantly reduce TC, TG, LDL- compared with hyperlipidemia model group C is horizontal, improves HDL-C level, and experimental result prompts the traditional chinese medicine composition of the invention to have apparent effect for reducing blood fat.
Although respectively display has certain effect to effect for reducing blood fat by extract A and B, by two groups of drug combinations of A, B Afterwards, under identical crude drug dosage, effect for reducing blood fat is significantly improved, and illustrates that compatibility of drugs of the present invention produces synergistic work With.
Two, infective use
Materials and methods
1.1 material
This group case 100, meet hyperlipidemia diagnostic criteria, what all cases were formulated in strict accordance with the Ministry of Public Health " guideline of clinical investigations of new Chinese medicine treatment hyperlipidemia " [Zheng Xiao cornel new Chinese medicine guideline of clinical investigations [M] .11 version.Beijing: China Medical Science Press, 2002:85.] in diagnosis, case selection standard.Patient is randomly divided into two Group, treatment group 50, wherein male 25, female 25；Average age (54.1 ± 5.8) year；Control group 50, wherein male 25, Female 25；Average age (53.8 ± 4.1) year.
1.2 treatment method
Treatment group takes the traditional chinese medicine composition of the invention, 3 times a day, each 4-8g (with crude drug meter)；Control group takes orally blood lipid Recovering capsule, each 0.4g, 3 times a day.Two groups of courses for the treatment of are 10 weeks, do not apply other lipid-lowering medicines in therapeutic process.Medication 10 weeks Blood TC, TG, HDL-C, LDL-C are checked afterwards.
1.3 criterion of therapeutical effect
Referring to " guideline of clinical investigations of new Chinese medicine treatment hyperlipidemia " criterion of therapeutical effect in 2002 [in Zheng Xiao cornel .11 editions Beijing of medicine Clinical Researches of New Drugs guideline [M]: China Medical Science Press, 2002:85].It is effective: TC after treatment Drop to normal range (NR) or decline >=20%；TG drops to normal range (NR) or decline >=40%；HDL-C rising >=0.26mmol/ L；LDL-C decline 20%.Effective: TC declines 10-20%；TG decline 20%~40%；HDL-C rises 0.104-0.26mmol/ L；LDL-C declines 10-20%.Invalid: lipids detection, which is not improved or improves, after treatment is not achieved effective standard.It the results are shown in Table 2, table 3.
2 two groups of Clinical efficacy comparisons (n=50) of table
3 two groups of pretherapy and post-treatment Blood Lipids of table (mmol/L, mean ± SD, n=50) compared with
Project Before treatment group's treatment After treatment group's treatment Before control group treatment After control group treatment
TC 7.22±1.87 5.78±0.67**Δ 7.31±1.23 6.67±0.97*
TG 3.43±1.34 2.47±0.54**Δ 3.49±1.02 2.91±0.76*
HDL-C 1.54±0.32 1.83±0.33**Δ 1.58±0.33 1.65±0.32*
LDL-C 5.56±0.65 4.42±0.59**Δ 5.61±0.59 4.89±0.55*
Note: each group compares * P < 0.05 before and after treatment；* P < 0.01；Δ P < 0.05 compared with the control group
The above results, which can be seen that the traditional chinese medicine composition of the invention group, has obvious therapeutic action to hyperlipidemia patient, can be with It is horizontal to reduce TC, TG, LDL-C, improves HDL-C level, also, its drug activity is even also advantageous over the prescribed preparation blood lipid of listing Recovering capsule provides new selection for clinical application.
In summary test is as it can be seen that the present invention after each taste material combination use, will play synergistic function, drop blood Rouge effect is substantially better than other compatibility prescriptions；Meanwhile the raw material that uses of the composition it is civil be also edible, good security, Conducive to diabetes patient's long-term use.

Claims (9)

1. the health care product or pharmaceutical composition of a kind of reducing blood lipid, it is characterised in that: its raw material is grouped by the group of following weight proportion At:
4-6 parts of black fruit fructus lycii of 2-4 parts of snow chrysanthemum 8-12 parts of white thorn 6-9 parts of wolfberry leaf 8-12 parts of Leaves of Hippophae L of 8-12 parts of safflower.
2. health care product according to claim 1 or pharmaceutical composition, it is characterised in that: its raw material is by following weight proportion Group is grouped as:
3 parts of snow chrysanthemum, 5 parts of black fruit fructus lycii, 10 parts of 7 parts of wolfberry leaf, 10 parts of Leaves of Hippophae L of 10 parts of safflowers of white thorn.
3. health care product according to claim 1 or 2 or pharmaceutical composition, it is characterised in that: it is powder by raw material, original Expect the dosage form that water or/and the extractive with organic solvent of medicine are prepared for active constituent.
4. health care product according to claim 3 or pharmaceutical composition, it is characterised in that: the dosage form is through gastrointestinal administration Dosage form.
5. health care product according to claim 3 or pharmaceutical composition, it is characterised in that: the dosage form be medicinal tea, granule, Capsule, powder, tablet, pill or oral solution.
6. the preparation method of health care product described in claim 1-5 any one or pharmaceutical composition, it is characterised in that: it includes such as Lower operating procedure:
(1) raw material crushing is weighed according to the ratio；
(2) by smashed raw material extracting in water, gained water extract carries out preparation.
7. health care product described in Claims 1 to 5 any one or pharmaceutical composition are in the health care product or drug of preparation reducing blood lipid Purposes.
8. health care product described in Claims 1 to 5 any one or pharmaceutical composition prevent, treat or assist in the treatment of in preparation high in fat The health care product of mass formed by blood stasis or the purposes in drug.
9. purposes according to claim 7 or 8, it is characterised in that: the health care product or pharmaceutical composition be reduce TC, TG, LDL-C are horizontal, improve the health care product or drug of HDL-C level.
CN201410542503.1A 2014-09-29 2014-09-29 A kind of food of reducing blood lipid, health care product or pharmaceutical composition Expired - Fee Related CN104306553B (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1416731A (en) * 2001-11-01 2003-05-14 中国科学院西北高原生物研究所 Blood fat-reducing anti-fatigue health food composition
CN101377059A (en) * 2007-08-30 2009-03-04 东丽纤维研究所（中国）有限公司 Durability natural object machining textile
CN103168890A (en) * 2013-04-08 2013-06-26 瓜州亿得生物科技有限公司 Medlar coreopsis tinctoria flower tea
CN103340263A (en) * 2013-06-23 2013-10-09 乌鲁木齐市海缘承乾商贸有限公司 Sanvitalia procumbens herbal tea and preparation method thereof
CN103977157A (en) * 2014-05-17 2014-08-13 苟春虎 Lycium ruthenicum eyesight-improving eye-protecting tea

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1416731A (en) * 2001-11-01 2003-05-14 中国科学院西北高原生物研究所 Blood fat-reducing anti-fatigue health food composition
CN101377059A (en) * 2007-08-30 2009-03-04 东丽纤维研究所（中国）有限公司 Durability natural object machining textile
CN103168890A (en) * 2013-04-08 2013-06-26 瓜州亿得生物科技有限公司 Medlar coreopsis tinctoria flower tea
CN103340263A (en) * 2013-06-23 2013-10-09 乌鲁木齐市海缘承乾商贸有限公司 Sanvitalia procumbens herbal tea and preparation method thereof
CN103977157A (en) * 2014-05-17 2014-08-13 苟春虎 Lycium ruthenicum eyesight-improving eye-protecting tea

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