CN104256618B - A kind of hypoglycemic food, health products or pharmaceutical composition - Google Patents
A kind of hypoglycemic food, health products or pharmaceutical composition Download PDFInfo
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- CN104256618B CN104256618B CN201410542588.3A CN201410542588A CN104256618B CN 104256618 B CN104256618 B CN 104256618B CN 201410542588 A CN201410542588 A CN 201410542588A CN 104256618 B CN104256618 B CN 104256618B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention provides a kind of hypoglycemic food, health products or pharmaceutical composition, its raw material is made up of the component of following weight proportion: snow chrysanthemum 15 parts, black fruit lyceum 37 parts, white thorn 5 10 parts, folium lycii 5 10 parts, 5 15 parts of safflower, Leaves of Hippophae L 5 15 parts.The present invention studies discovery, after being used by each taste material combination, has played synergistic function, and its hypoglycemic activity is substantially better than other compatibility prescriptions；Meanwhile, the raw material that said composition uses among the people also be edible, security well, beneficially diabetes patient's long-term taking.
Description
Technical field
The invention provides a kind of hypoglycemic food, health products or pharmaceutical composition.
Background technology
Diabetes are one group of metabolic diseases being characterized with hyperglycaemia.Hyperglycaemia be then due to defect of insulin secretion or
Its biological agent is impaired, or both have concurrently and cause.Long-standing hyperglycaemia during diabetes, causes various tissue, particularly eye,
Kidney, heart, blood vessel, neural chronic lesion, dysfunction.
Diabetes B original name, Adult Onset's patients with type Ⅰ DM, how 35～the sequela of 40 years old, accounts for diabetic 90%
Above.Diabetes B produces the ability of insulin in the patient and not completely loses, and the insulin in the patient having even produces
Too much, but the action effect of insulin is poor, and insulin the most in the patient is a kind of shortage relatively, can pass through some mouth
Take the secretion of insulin in medicine irritation body.But some client need use of exogenous insulins are still had to the later stage.
Diabetes B diagnostic criteria in 2010: 1. Glycohemoglobin HbA1c >=6.5%.2. fasting blood-glucose FPG >=
7.0mmol/l.In being defined as at least 8 hours on an empty stomach, empty calory is taken in.3. 2 hours blood glucoses during oral glucose tolerance test >=
11.1mmol/l.4. with typical hyperglycaemia or the patient of hyperglycaemia crisis symptom, random blood sugar >=11.1mmol/l.?
During without clear and definite hyperglycaemia, standard 1～3 should be confirmed by duplicate detection.
Current diabetes mellitus patient is numerous, and research and development treatment can hypoglycemic medicine be that the research of medical circle is popular.
Summary of the invention
It is an object of the invention to provide a kind of effective hypoglycemic food, health products or pharmaceutical composition.
Specifically, the invention provides a kind of hypoglycemic food, health products or pharmaceutical composition, its raw material is by weighing as follows
The component composition of amount proportioning:
Snow chrysanthemum 1-5 part, black fruit lyceum 3-7 part, white thorn 5-10 part, folium lycii 5-10 part, safflower 5-15 part, Leaves of Hippophae L 5-15
Part.
The present invention studies discovery, after above-mentioned 6 taste material combination are used, and hypoglycemic drug activity under equal dosage
It is significantly better than snow chrysanthemum and the formula of black fruit lyceum 2 taste medicine, and white thorn, folium lycii, safflower and the formula of Leaves of Hippophae L 4 taste medicine, this
After 6 taste material combinations are used by the one result explanation present invention, create synergistic function.
Further, its raw material is made up of the component of following weight proportion:
Snow chrysanthemum 2-4 part, black fruit lyceum 4-6 part, white thorn 6-9 part, folium lycii 6-9 part, safflower 7-12 part, Leaves of Hippophae L 7-12
Part.
Further, its raw material is made up of the component of following weight proportion:
Snow chrysanthemum 3 parts, black fruit lyceum 5 parts, white thorn 7 parts, folium lycii 7 parts, 10 parts of safflower, Leaves of Hippophae L 10 parts.
Snow chrysanthemum:
Compendium of Materia Medica: snow chrysanthemum, former times people calls it can remove wind-heat, kidney-nourishing tonifying yin, and with controlling all public attention mesh, its purport is profound and subtle.Book on Chinese herbal medicine warp
Dredge: snow chrysanthemum peace stomach, Li Wumai, adjust four limbs, profit qi and blood person.In successive dynasties pharmacopeia, the medical value about snow chrysanthemum is recorded a lot of: many
Becoming " the legendary god of farming hundred grass warp " of Qin Han dynasty, its row snow chrysanthemum is that hundred grass are top grade, says: snow chrysanthemum bitter is put down, and head is dazzled and swollen and ache, and mesh is intended to take off,
Lacrimation, skin is the most hungry, for a long time clothes profit qi and blood, makes light of one's life by commiting suicide and resistance to always prolongs life.Well-known doctor's Tao Hongjing says that chrysanthemum cures mainly that " wind is dizzy, can make hair not
In vain ".
The traditional Chinese medical science is thought: coreopsis tinctoria is cool in nature, has the effects such as wind and heat dispersing, brain nourishing and eyesight improving, removing toxicity for detumescence.And avenge chrysanthemum to gold
Staphylococcus aureus, corynebacterium diphtheriae and shigella dysenteriae have stronger inhibitory action, therefore to pneumonia, rhinitis, bronchitis, throat
Swelling and ache etc. has obvious curative effects, has sterilization, antibacterial, anti-inflammatory, preventing cold and effect of chronic enteritis.
Snow chrysanthemum has regulation three high effects, can reach the isohydria of human body with rubbish in softening blood vessel, removing body,
Mainly coronary heart disease, high fat of blood there is special curative effect.
Black fruit lyceum:
" Uygur medicine will " is recorded, and Uygur doctor commonly uses lycium ruthenicum fruit and root skin treatment urethral calculus, tinea scabies, tooth
Oulorrhagia etc., among the people as strengthening by means of tonics, improving eyesight and depressor.
The Tibetan medicine classical works such as the Four-Volume Medical Code, " Jingzhubencao " record black matrimony vine be used for: treatment cardiopyretic disease, heart disease,
Irregular menstruation, menelipsis etc. and drug effect are notable.Strengthening by means of tonics of making among the people, depressor is used.Black fruit lyceum can strengthen immunity, delay
Aging, tonifying kidney and benefiting sperm, pre-anti-cancer, promote the production of body fluid to quench thirst, improve circulation, blood-enriching tranquillizing, improve sleep, moisten the lung and relieve the cough, delaying senility.
Black fruit lyceum can have obvious antifatigue, protects the liver, moreover it is possible to antitumor, dredging vascellum, step-down, protects Cardiovascular System.
White thorn:
White thorn has higher medical value, is used as medicine in northwest minority areas with a long history, and the husky district people use white thorn
Treat the history of existing centuries of catching cold, catch a cold, have a headache and have a stomach upset, much the most on the books.Ming Dynasty's physician's Li Shizhen (1518-1593 A.D.) once existed
Describing in Compendium of Material Medica, " smell is pungent, cold, nontoxic for white thorn.Cure mainly angina pectoris, the swollen purulence of bursting of pain, pain relieving.Treat husband deficient, impotence
Essence goes out certainly, kidney tonifying gas, benefit marrow etc. ".The entitled east of Bai Cigu, husky fluffy rice, popular name western sand cherry.The Northern Wei Dynasty Important Arts for the People's Welfare: " east
, drought-enduring Salt And Alkali Tolerance, seed is used as medicine, edible ".Supplement to the Herbal: " east, taste is sweet flat, nontoxic, and benefit gas is made light of one's life by commiting suicide, and clothes are the most hungry for a long time,
Hard muscles and bones ".Its fruit and branches and leaves are to be utilized as Chinese herbal medicine, and fruit has strengthening the spleen and stomach, aid digestion, hypertensive tranquilizing, the merit induced sweat
Effect, its leaf is among the people for treating spasm, neuralgia and cardiac arrhythmia.In Xinjiang, Nitraria sibirica is that medicine is commonly used by the Uygur nationality
Thing, claims Acker sheep Plutarch crow to draw lid, has the effects such as strengthening the spleen and stomach, hypotensive, regulating menstruation and activating blood, lactagogue.Local ethnic group is with white
The diseases such as bur treatment indigestion and hypertension dizziness, evident in efficacy.Nitraria tangutorum is also conventional among the people in anaesthetic
Medicine, referred to as craze for Japanese pop culture not lattice.Can strengthening the spleen and stomach, aid digestion, effect induced sweat of also calming the nerves, cure mainly weakness of the spleen and the stomach, qi-blood deficiency, disappear
Change the diseases such as bad and neurasthenia.Sting in vain used by the present invention, for white bur.
Folium lycii:
As far back as the Ming Dynasty, Li Shizhen (1518-1593 A.D.) mentions " spring adopts folium lycii, name sky essence grass ", sky mentioned here essence in Compendium of Material Medica
Grass i.e. refers in particular to the folium lycii tender shoots of " rhizome with spend reality, tidy up without gurry ".
Lycium leaf tea has and alleviates frigidity, stomach invigorating, liver protecting and kidney invigorating, suppresses pulmonary tuberculosis, eliminates constipation, relieving insomnia, adjusts
Reason low blood pressure, anaemia, treat various eye illness and oral inflammation, and can be with skin-protecting face nursing.Drink for a long time, especially can be with treatment
The physique cold of insufficiency type, builds up resistance, it is possible to play certain effect improving physique.Main containing glycine betaine, carrotene, Vitamin C
Acid, linoleic acid, there is the amino acid of ten several needed by human such as asparatate, glutamic acid, methionine, taurine, and rich in calcium
The trace element of the multiple needed by human such as Ca, iron Fe, zinc Zn, selenium Se, vitamin B1, vitamin B2, vitamin C.Calcic high with
The hypotensive relation with reducing blood lipid.Research proves, taking in high calcium can effectively reduce blood pressure, and educating new Lycium leaf tea has and significantly drop blood
Pressure effect, relevant with containing the calcium enriched.Containing abundant folium lycii albumen in Lycium leaf tea.
Safflower:
Compendium of Material Medica records safflower can " invigorate blood circulation, moisturize, pain relieving, dissipate swollen stimulating the menstrual flow ".Think in the traditional Chinese medical science that safflower taste is pungent, micro-
Bitter, warm in nature, the thoughts of returning home and Liver Channel, having invigorates blood circulation stimulates the menstrual flow, effect of blood stasis removing analgesic, lowering blood pressure and blood fat, for amenorrhoea, dysmenorrhoea, falls
Beat the diseases such as damage, coronary heart diseases and angina pectoris and hypertension.Safflower becomes prevention and treatment coronary heart disease, cardiac muscle in modern clinic
The important Chinese medicine of the disease such as infarct and cerebral thrombus.Modern pharmacology experiment shows: safflower can improve heart and brain blood oxygen supply, alleviate ischemic
Property damage, anticoagulation, resist myocardial ischemia, suppress the pharmacological actions such as platelet aggregation, anti-oxidant, antitumor and anti-inflammatory.
Leaves of Hippophae L:
There is effective Adjust-blood lipid, the effect of control body weight, may be used for prevention and treatment hyperlipidemia.Blood can be reduced
Cholesterol and effect of triglycerides.
Wherein, described composition be by the powder of raw material, bulk drug water or/and extractive with organic solvent is active component
The formulation being prepared from.
Described organic solvent can be selected from ethanol, methyl alcohol, n-butanol, ethyl acetate, chloroform etc..Certainly, in order to ensure peace
Quan Xing, can only select ethanol, but, if utilizing existing except organic residue technology, other organic solvents also can be used.
Further, described formulation is through gastrointestinal administration formulation.
Further, described formulation is medicinal tea, granule, capsule, powder, tablet, pill or oral liquid.
In described formulation, it is also possible to include conventional use of auxiliary material, such as excipient, adhesive, disintegrant, lubricant, rectify
Taste agent etc..
Present invention also offers the preparation method of above-mentioned food, health products or pharmaceutical composition, it includes operating as follows step
Rapid:
(1) weigh raw material by proportioning to pulverize；
(2) the raw material extracting in water after pulverizing, gained water extract carries out preparation.
Extracting in water of the present invention can be temperature leaching, decocting, ultrasonic, microwave or refluxing extraction.
In one specific embodiment of the present invention, the mode of decocting is used to extract, such as decocting 3 times, each 5-15
Times amount water, decocts 0.5-2h every time.
Present invention also offers above-mentioned food, health products or pharmaceutical composition prepare hypoglycemic food, health products or
Purposes in medicine.
Present invention also offers above-mentioned food, health products or pharmaceutical composition and prevent, treat or assist treatment sugar in preparation
Purposes in food, health products or medicine that urine is sick.
The present invention studies discovery, after being used by each taste material combination, has played synergistic function, and its hypoglycemic activity is bright
Show and be better than other compatibility prescriptions；Meanwhile, the raw material that said composition uses among the people also be edible, security well, beneficially glycosuria
Patient's long-term taking.
Detailed description of the invention
The preparation of embodiment 1 present composition
Prescription: snow chrysanthemum 3g, black fruit lyceum 5g, sting 7g, folium lycii 7g, safflower 10g, Leaves of Hippophae L 10g in vain.
Preparation method: weigh each medicinal material by prescription, is placed in 50～60 DEG C of baking ovens drying and pulverizes, merging decoction 3 times, and first
The secondary 12 times amount water that add, soak 1 hour, and heating is separately added into 10 times amount soak by water 1h after boiling 1h every time, filter, and merge filter
Liquid, reduced pressure concentration, add appropriate microcrystalline cellulose, conventionally make capsule.
The preparation of embodiment 2 present composition
Prescription: snow chrysanthemum 2g, black fruit lyceum 6g, sting 9g, folium lycii 9g, safflower 12g, Leaves of Hippophae L 12g in vain.
Preparation method: weigh each medicinal material by prescription, is placed in 50～60 DEG C of baking ovens drying and pulverizes, merging decoction 2 times, and first
The secondary 10 times amount water that add, soak 1 hour, and 1.5h is boiled in heating, and second time adds 8 times amount soak by water 1.5h, filters, merging filtrate,
Reduced pressure concentration, adds appropriate dextrin, conventionally makes granule.
The preparation of embodiment 3 present composition
Prescription: snow chrysanthemum 4g, black fruit lyceum 4g, sting 6g, folium lycii 6g, safflower 7g, Leaves of Hippophae L 7g in vain.
Preparation method: weigh each medicinal material by prescription, is placed in 50～60 DEG C of baking ovens drying and pulverizes, merging decoction 3 times, and first
The secondary 8 times amount water that add, soak 0.5 hour, and heating adds 10 times amount soak by water 1h after boiling 0.5h, and third time adds 6 times amount decoctings
Boil 0.5h, filter, merging filtrate, reduced pressure concentration, add appropriate amount of starch, dextrin and magnesium stearate, conventionally make sheet
Agent.
The preparation of embodiment 4 present composition
Prescription: snow chrysanthemum 3g, black fruit lyceum 5g, sting 7g, folium lycii 7g, safflower 10g, Leaves of Hippophae L 10g in vain.
Preparation method:: weigh each component dry product respectively, rinse well with trickle, measure moisture respectively, be placed in drying room baking
Do or dry, being then placed in pulverizer pulverizing respectively, sieve, continue to employ the qualified meal between 10-40 mesh, by gained
Qualified meal is dried again, by the water content control of meal within 5%, is pulverized by underproof meal, mistake again
Sieve, continues to employ the qualified meal between 10-40 mesh, weighs the meal that each component is qualified by weight percentage, is placed in three-dimensional motion and mixes
Conjunction machine mixes, after infrared sterilizing, sampling inspection, after the assay was approved, carry out being packaged into bag in packaging machine of tea bag,
Carry out outer packaging again, be finished product.
The drug activity research of embodiment 5 present composition
In the present embodiment test, all select the composition of embodiment 1 preparation.Dosage is with crude drug gauge.
1. intact animal hypoglycemic experiment
Select healthy adult mouse, be grouped by the fasting blood sugar level of 4 hours, select 1 control group and 1 dosage group at random.
Control group gives the distilled water of same volume, and dosage group gives the high dose concentration present composition (1.6g/kg), and continuous 30
My god, survey fasting blood sugar (before fasting is with experiment), compare two treated animal blood glucose values.
2. hyperglycemia model hypoglycemic experiment
2.1 modeling method
Select healthy adult mouse, after adapting to 1 day, take 15 animal fasting 4 hours at random, survey fasting blood-glucose, as this batch
Secondary animal basal plasma glucose value.Animal fasting subsequently 24 hours (freely drinking water), injects alloxan (using front Fresh) modeling,
Mouse 48mg/kg BW.iv.Animal fasting 4 hours after 5 days, survey blood sugar, and blood glucose value 10-25mmol/L is hyperglycemia model success
Animal.
2.2 hyperglycemia model animal hypoglycemic is tested
Select hyperglycemia model animal to be grouped by the fasting blood sugar level of 4 hours, select 1 model control group and 3 agent at random
Amount group (between group, difference is not more than 1.1mmol/L).Dosage group gives the variable concentrations present composition [large, medium and small 3 dosage groups
(1.6,0.8,0.4g/kg)], model control group gives the distilled water of same volume, continuous 30 days, surveys fasting blood sugar (fasting
Before experiment), relatively each treated animal blood glucose value and blood sugar declines percentage.
3. prescription contrast test
Be currently known can Traditional Chinese medicine for decreasing blood sugar large number of, but, how can obtain compatibility good group precise and appropriate, active
Compound, is the problem constantly studied of researcher.In addition to the present composition, inventor's early stage also have selected other two and joins
Side, and according to the method for 2.2, the hypoglycemic activity of each composition is compared:
A extract group: snow chrysanthemum 3 parts, black fruit lyceum 5 parts
B extract group: white thorn 7 parts, folium lycii 7 parts, 10 parts of safflower, Leaves of Hippophae L 10 parts
C extract group: snow chrysanthemum 3 parts, black fruit lyceum 5 parts, white thorn 7 parts, folium lycii 7 parts, 10 parts of safflower, Leaves of Hippophae L 10 parts.
Each group extracting method is all carried out according to embodiment 1.
(3) experimental result
1, the capsule of the present invention impact on normal mouse fasting blood-glucose: normal mouse fasting blood-glucose is had no significant effect (P ＞
0.05), experimental result is shown in Table 1.
The impact on normal mouse fasting blood-glucose of table 1 present composition
2, hyperglycemia model hypoglycemic experiment
2.1 results observing modeling: test result indicate that, the blood glucose value of model group mouse is 18.987 ± 4.012,
It is hyperglycemia model success animal between 10-25mmol/L, the results are shown in Table 2.
Table 2 alloxan induced diabetes mouse model result
2.2 hyperglycemia model animal hypoglycemics experiment: as shown in Table 3, capsule of the present invention large, medium and small dosage group blood glucose value and
Blood sugar declines percentage and all reduces, and compares with model group and has significant statistical significance (P ＜ 0.01), and experimental result is shown in Table 3.
The impact on blood glucose in diabetic mice of table 3 present composition
Note: * * is p ＜ 0.01 compared with model group
2.3 by table 4 experimental result it is recognized that while extract A and B the most all show hypoglycemic activity is had conspicuousness effect
Really, but, after each material combination is used by the present invention, the drug activity under Isodose is substantially better than extract A, B (p ＜
0.05), show that each material combination creates synergistic function.
The impact on blood glucose in diabetic mice of table 4 different components
Note: * * is p ＜ 0.01 compared with model group；Δ is p ＜ 0.05 compared with C group
Embodiment 6 infective use:
(1) experiment material
1, given the test agent: make capsule, 4g crude drug/grain according to method described in the embodiment of the present invention 1.
2, experimenter selects: select by " health food inspection and assessment technique specification " requirement, the equal warp of each experimenter
Cross Hospital Physical Examination and turn out to be diabetes B patient.
3, experimental design and packet: standard compliant diabetes B patient is balancedly randomly divided into test-meal group and compares
Group, wherein test-meal group 100 example, control group 100 example.
(2) experimental technique
Test-meal group takes the capsule made according to method described in the embodiment of the present invention 1, each 2,3 times on the one, control group
Taking placebo, instructions of taking, dosage are identical with test-meal group, Continuous Observation 90 days.
(3) experimental result
1, safety indexes
(1) general status sign: test-meal group and control group on pretreatment after, spirit, sleep, diet, stool and urine, blood pressure etc.
Without significant change, all act normally.
(2) blood, urine, feces routine inspection: test-meal group and control group on pretreatment after, blood, urine, feces routine inspection are all without obvious
Change.
(3) Liver and kidney function inspection: test-meal group and control group on pretreatment after, Liver and kidney function inspection has no significant change.
(4) Chest X-rays, electrocardiogram, Abdominal B type ultrasonography inspection: test-meal group and control group on pretreatment, Chest X-rays, electrocardiogram, Abdominal B type ultrasonography
Check the most normal.
2, efficacy measures
(1) fasting blood-glucose:
Comparing with before test-meal after test-meal group test-meal, fasting blood-glucose has declined, and has significant difference (* * P ＜ 0.01)；Two
Before group test-meal, there was no significant difference for fasting blood-glucose, test-meal group fasting blood-glucose fall and decline percentage and control group after test-meal
Relatively, there is significant difference (* * P ＜ 0.01), and test-meal group is evaluated fasting blood-glucose and declined percentage ＞ 10%, and the present invention is described
Composition has the effect significantly reducing fasting blood-glucose, and experimental result is shown in Table 5
The change of fasting blood-glucose before and after table 5 test-meal
Note: compare with control group, * * P ＜ 0.01
(2) 2h-plasma glucose:
After test-meal group test-meal, postprandial blood sugar compares with before test-meal, has significant difference (* * P ＜ 0.01)；Two groups of meal before test-meal
There was no significant difference for rear 2h blood sugar, and after test-meal, test-meal group postprandial blood sugar fall and decline percentage compare with control group, have
Significant difference (* * P ＜ 0.01), and test-meal group evaluation fasting blood-glucose decline percentage ＞ 10%, illustrate that capsule of the present invention has aobvious
Writing the effect reducing 2h-plasma glucose, experimental result is shown in Table 6.
The change of 2h-plasma glucose before and after table 6 test-meal
Note: compare with control group, * * P ＜ 0.01
Summary test is visible, after each taste material combination is used by the present invention, has played synergistic function, and it drops blood
Sugar effect is substantially better than other compatibility prescriptions；Meanwhile, the raw material that said composition uses among the people also be edible, security well,
It is beneficial to diabetes patient's long-term taking.
Claims (9)
1. a hypoglycemic food, health products or pharmaceutical composition, it is characterised in that: its raw material is by the group of following weight proportion
It is grouped into:
Snow chrysanthemum 1-5 part, black fruit lyceum 3-7 part, white thorn 5-10 part, folium lycii 5-10 part, safflower 5-15 part, Leaves of Hippophae L 5-15 part.
Food the most according to claim 1, health products or pharmaceutical composition, it is characterised in that: its raw material is by following weight
The component composition of proportioning:
Snow chrysanthemum 2-4 part, black fruit lyceum 4-6 part, white thorn 6-9 part, folium lycii 6-9 part, safflower 7-12 part, Leaves of Hippophae L 7-12 part.
Food the most according to claim 2, health products or pharmaceutical composition, it is characterised in that: its raw material is by following weight
The component composition of proportioning:
Snow chrysanthemum 3 parts, black fruit lyceum 5 parts, white thorn 7 parts, folium lycii 7 parts, 10 parts of safflower, Leaves of Hippophae L 10 parts.
4. according to food, health products or the pharmaceutical composition described in claims 1 to 3 any one, it is characterised in that: it be by
The powder of raw material, bulk drug water or/and extractive with organic solvent is the formulation that active component is prepared from.
Food the most according to claim 4, health products or pharmaceutical composition, it is characterised in that: described formulation is through stomach and intestine
Canal drug administration formulation.
Food the most according to claim 4, health products or pharmaceutical composition, it is characterised in that: described formulation be medicinal tea,
Granula, capsule, powder, tablet, pill or oral liquid.
7. food, health products or the preparation method of pharmaceutical composition described in claim 1-6 any one, it is characterised in that: it
Including following operating procedure:
(1) weigh raw material by proportioning to pulverize；
(2) the raw material extracting in water after pulverizing, gained water extract carries out preparation.
8. described in claim 1～6 any one, food, health products or pharmaceutical composition are preparing hypoglycemic food, health care
Purposes in product or medicine.
9. pharmaceutical composition described in claim 1～6 any one prevents in preparation, treat or assists the medicine for the treatment of diabetes
In purposes.
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| CN201410542588.3A CN104256618B (en) | 2014-09-29 | 2014-09-29 | A kind of hypoglycemic food, health products or pharmaceutical composition |
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| CN104256618B true CN104256618B (en) | 2016-08-24 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104997937B (en) * | 2015-07-21 | 2019-11-29 | 中国科学院西北高原生物研究所 | A kind of blood sugar reducing food containing fructus lycii, health care product or pharmaceutical composition |
| CN107484854A (en) * | 2016-06-12 | 2017-12-19 | 李忱 | A kind of white thorn tea and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416731A (en) * | 2001-11-01 | 2003-05-14 | 中国科学院西北高原生物研究所 | Blood fat-reducing anti-fatigue health food composition |
| CN103168890A (en) * | 2013-04-08 | 2013-06-26 | 瓜州亿得生物科技有限公司 | Medlar coreopsis tinctoria flower tea |
| CN103340263A (en) * | 2013-06-23 | 2013-10-09 | 乌鲁木齐市海缘承乾商贸有限公司 | Sanvitalia procumbens herbal tea and preparation method thereof |
| KR101377059B1 (en) * | 2012-11-16 | 2014-04-01 | 김재현 | Manufacturing method of enhanced flavor tea using dried chrysanthemum flower and dried wolfberry |
| CN103977157A (en) * | 2014-05-17 | 2014-08-13 | 苟春虎 | Lycium ruthenicum eyesight-improving eye-protecting tea |
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2014
- 2014-09-29 CN CN201410542588.3A patent/CN104256618B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416731A (en) * | 2001-11-01 | 2003-05-14 | 中国科学院西北高原生物研究所 | Blood fat-reducing anti-fatigue health food composition |
| KR101377059B1 (en) * | 2012-11-16 | 2014-04-01 | 김재현 | Manufacturing method of enhanced flavor tea using dried chrysanthemum flower and dried wolfberry |
| CN103168890A (en) * | 2013-04-08 | 2013-06-26 | 瓜州亿得生物科技有限公司 | Medlar coreopsis tinctoria flower tea |
| CN103340263A (en) * | 2013-06-23 | 2013-10-09 | 乌鲁木齐市海缘承乾商贸有限公司 | Sanvitalia procumbens herbal tea and preparation method thereof |
| CN103977157A (en) * | 2014-05-17 | 2014-08-13 | 苟春虎 | Lycium ruthenicum eyesight-improving eye-protecting tea |
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