CN1857458A - Health product and medicine and their preparing method - Google Patents
Health product and medicine and their preparing method Download PDFInfo
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- CN1857458A CN1857458A CN 200610041923 CN200610041923A CN1857458A CN 1857458 A CN1857458 A CN 1857458A CN 200610041923 CN200610041923 CN 200610041923 CN 200610041923 A CN200610041923 A CN 200610041923A CN 1857458 A CN1857458 A CN 1857458A
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Abstract
The present invention relates to new use of water extract of plant. The leaves of Sibiraea angustata and Sibiraea laevigata of Sibiraea in Rosaceae are prepared into health tea and medicine capable of reducing blood fat, promoting digestion, eliminating constipation and slimming.
Description
Technical field
The present invention relates to the purposes of a class plant and the new purposes of this class vegetation water extract.The present invention more exactly relates to the new purposes of the water extract of a kind of purposes of rosaceous plant and this class plant.
Background technology
Certain plants makes it be subjected to scientific and technical personnel and pays close attention to owing to have special physiologically active.Prepare the health product of necessary for human and the medicine of preparation treatment some diseases is present stage scientific and technical personnel's a great research direction with the plant of this class.
Because the development of science and technology makes modern society that very big change take place, and has also improved mankind itself's life greatly.Cause the mankind but also make, particularly a series of distinctive modern diseases appear in the people in the developed regions life.For example: it is comparatively general that existing town dweller suffers from diseases such as hyperlipidemia, obesity.And dyspepsia and constipation symptom are increased because of unsuitable diet and living habit.
Hyperlipemia is multiple disease, for example the major incentive of diabetes, hypertension, coronary heart disease, myocardial infarction etc.; Many clinically Western medicine in order to blood fat reducing are as bezafibrate, Inositol Hexanicotinate, lovastatin etc.
Though constipation is not a kind of disease, being more common in after the medication of multiple disease bad should.Constipation usually causes person discomfort, and original disease increases the weight of, and quality of life descends, and may cause some diseases simultaneously.According to China's present situation, advocate based on Chinese medicine, from people's whole angle, rationally use qi-blood-body fluid, negative and positive internal organs basic theories, medication from different perspectives both can be controlled table, also can reach the purpose of effecting a permanent cure.
For the Drug therapy of constipation, have following seven kinds at present: 1. osmotic laxative (cellulose) can be strengthened colon or full gastrointestinal tract transhipment, and adsorption moisture makes the soft easy discharge of stool.As: pectin, Herba Plantaginis, plant cellulose etc.2. saline cathartic: in intestinal, be difficult for absorbing, form hyperosmotic state in the enteric cavity.As magnesium sulfate.3. irritant laxative: stimulate intestinal mucosa, promote enterokinesia, stop intestinal juice to be absorbed and play the catharsis effect by intestinal wall.As: Folium Sennae, phenolphthalein, Semen Ricini wet goods.4. osmotic laxative treatments: by osmosis Water-Electrolyte is stayed in the enteric cavity and by normal flora and be decomposed into lactic acid and acetic acid etc., further improve the osmotic pressure catharsis.As: lactulose etc.5. digestive tract power reinforcing medicine is as cisapride.6. emollient laxative: as glycerin, liquid Paraffin etc.7. Chinese medicine preparation: as Fructus Cannabis Bolus, BUZHONG YIQI TANG etc.
Obesity is the syndrome that is caused by multiple factors such as heredity, metabolism, endocrine disturbance and bad life habits, also is the risk factor of multiple diseases, such as hypertension, coronary heart disease, hyperlipidemia, diabetes and other diseases.Can cause the problem of a series of psychology and social adjustment aspect, as feel oneself inferior, degradation under forgetful, the mental retardation, social adjustment's power.Same side effect owing to Western medicine, making with the form of single compound recipe, becomes the new trend of current fat-reducing medication by more Chinese medicine.
The main method of medicine fat-reducing has: 1. appetite inhibiting; 2. promote the energy metabolism parahormone; 3. digest and assimilate inhibition; 4. local fat decomposition etc.
Though some can be treated or relief of symptoms at the synthetic drug of above-mentioned disease, this type of medicine is many with bad side effect.Utilize natural product, plant particularly, with and sufferers such as extract control hyperlipidemia, obesity be a current main research direction.The achievement of many this respects is disclosed on Chinese patent and other professional magazine.
Rosaceae (Rosaceae) Xianbei an ancient nationality in China Pittosporum (Sibiraea) plant narrow leaf Xianbei an ancient nationality in China spends (Sibiraea angustata) to be used to dispelling wind and heat pathogens in traditional Tibetan medicine, cures mainly calentura and eqpidemic disease.Have in Tibetan's traditional food in addition: the branch that narrow leaf Xianbei an ancient nationality in China is spent is simmered ripe with ash, or its infructescence is taken after mixing it with water after with the little stir-fry of little fire, in order to the clearing away stomach-heat building body.
The water of the open narrow leaf Xianbei an ancient nationality in China of existing document spray bar is carried thick extractum and is had anti-CCl
4The effect of hepatic injury, enhancing human body immunity function.
The 437th page of " Chinese herbal medicine " magazine of 1995 the 26th the 9th phases of volume once disclosed " research that willow tea is regulated the lipid metabolism effect ".This branch water that studies show that narrow leaf Xianbei an ancient nationality in China spends is carried thick extractum and is had the effect of regulating lipid metabolism.
The water extract of narrow leaf Xianbei an ancient nationality in China spray bar and the antitumor action that ethyl acetate extract has antioxidation, raising immunity are also disclosed at " progress of medicine willow tea among the people " (" Chinese practical Chinese and western medicine magazine " 2005.VOL. (18) NO.10P1531).
Existing research all is to spend at narrow leaf Xianbei an ancient nationality in China, and its to use all be to be main object with its branch, its resource is subjected to certain restriction, and can be unfavorable for the generation of plant to the harvesting of plants shoots, even the destruction to vegetation may occur.
Summary of the invention
The invention provides and utilize Rosaceae (Rosaceae) Xianbei an ancient nationality in China Pittosporum (Sibiraea) plant, narrow leaf Xianbei an ancient nationality in China spends (Sibiraea angustata) and Xianbei an ancient nationality in China to spend (Sibiraea laevigata (L.) Maxim), this class is the new purposes of plant greatly so, and the new purposes of the water extract of this class plant is provided simultaneously.
First purpose of the present invention is to spend (Sibiraea angustata) or Xianbei an ancient nationality in China to spend the blade of (Sibiraea laeviga (L.) Maxim) to prepare blood fat reducing with Rosaceae (Rosaceae) Xianbei an ancient nationality in China Pittosporum (Sibiraea) plant narrow leaf Xianbei an ancient nationality in China, or facilitating digestion, or the adjusting constipation, perhaps be used to the health tea of losing weight.Second purpose of the present invention is to spend (Sibiraea angustata) or Xianbei an ancient nationality in China to spend the blade of (Sibiraea laevigata (L.) Maxim) or the aqueous extract of branch or infructescence extraction with Rosaceae (Rosaceae) Xianbei an ancient nationality in China Pittosporum (Sibiraea) plant narrow leaf Xianbei an ancient nationality in China, the medicine of preparation blood fat reducing, perhaps dyspeptic medicine is treated in preparation, perhaps treat the medicine of constipation, perhaps be used to prepare the medicine of fat-reducing.
Therefore the present invention can make its available part increase greatly owing to be the blade that mainly adopts Xianbei an ancient nationality in China's flower plant, simultaneously the harvesting of the blade stage of more now adopting is plucked branch and will more help protection to plant and vegetation.
The present invention is to reach the effect of regulating constipation by strengthening small intestinal peristalsis power to the treatment constipation, it is advantageous that the stimulation of intestinal mucosa very for a short time, also can not cause the desaturation of defecating, and toxic and side effects is minimum; For fat-reducing, the advantage of this tea maximum is not can appetite-suppressing or absorption, and can reduce fat.Its effect is better than the medicine and the method for existing treatment constipation and fat-reducing.
The experiment that the present invention is correlated with shows that Xianbei an ancient nationality in China's flower plant belongs to innocuous substance, and it is edible to be safe.Relevant experiment also shows, Xianbei an ancient nationality in China's flower plant has the promotion intestinal peristalsis promoting, promote the function of intestinal propulsion, have digestant function and promote stool to drain, alleviate and the secret function of treatment potbellied, particularly the aid digestion convenient mechanism of this kind of plant is different fully with the mechanism of more existing treatment constipation medicines, and its effect will be better than prior art.Row's fat function that Xianbei an ancient nationality in China's flower plant is had makes it become a kind of ideal blood fat reducing, diet food or medicine.
The specific embodiment
1. the preparation method of Xianbei an ancient nationality in China's flower health tea:
Selecting leaf of Sibiraea laevigata (Linn.) Maxim. exsiccant, no insect pest to concoct (by the frying production method of ordinary tea leaves) through processing can direct boiled water bubble drink.
Drying that perhaps will be through selecting, the leaf of Sibiraea laevigata (Linn.) Maxim. of no insect pest be pulverized behind sauting, cross 20 mesh sieves, and splendid attire is in netted gauze pouch, every bag with 2 grams for well, boiled water steeps to be drunk.
This tea has been carried out Preliminary Clinical Observation, had 23 people and participate in (9 men, 14 woman), age 23-80 year; Teacher 3 people wherein, doctor 4 people, university student 7 people, retired cadre 6 people, professional 3 people.Physique differs, and wherein 2/3 left and right sides person has the constipation symptom.Take this tea 1-6 week and do not wait, institute's feedback information gathers as follows:
1) during taking the present invention, the generation of all reacting hunger sensation basically early 0.5-1 hour than usual, appetite increases; Illustrate that this tea is aid digestion, and the side effect of unrestraint appetite.If remain appetite at ordinary times, can reduce body weight.
2) take the present invention, can make free movement of the bowels, but do not have the symptom of diarrhea of following: stool is shaped, and has softening slightly; No desaturation or loose stool etc.1-2 took after week at interval, and between lay-off period, it is still unobstructed to defecate, and illustrates that this beverage has good constipation regulatory function.
3) during clothes the present invention, majority's reaction amount of drinking water increases to about original 1.5 times, and the urine number of times increases, and illustrates that this tea can promote the metabolism of human body by increasing the excretory effect of poisonous substance in the body body.
Take to observe during the present invention and show, take coldrex, depressor etc. simultaneously, uncomfortable reaction is not arranged.
2, exsiccant leaf of Sibiraea laevigata (Linn.) Maxim. is pulverized, crossed 20 mesh sieves; Get ground product 100g and place the 1000ml beaker, add water 500ml and soak 0.5h, boil back boiling 1h, filter; Residue adds water 250ml and extracts 1.5h; Filter, residue adds water 200ml and extracts 1h, filters, and merges 3 times filtrate, makes thick extractum, vacuum drying; Obtain being the solid of pitchy, its every g is equivalent to crude drug 6.24g.
3, Xianbei an ancient nationality in China's flower extract acute toxicity testing
With Kunming mouse, each 20 of male and female, by body weight random packet, every group 5 female 5 heros, dosage is respectively: 7.50g (suitable crude drug amount, as follows)/Kgbw, 15.00g/Kgbw, 30.00g/Kgbw, 60.00g/Kgbw, each group is behind the 16h that stops eating, and gastric infusion was observed 7 days continuously, write down the toxic reaction situation and the dead number of elements of each treated animal, to determine the median lethal dose(LD 50) (LD of extract to mice
50).
Viewing duration, each treated animal all finds no obvious toxic reaction, and also none example is dead, illustrates that Xianbei an ancient nationality in China's flower extract is LD to median lethal dose(LD 50) (acute toxicity) female, male mice
50＞60g/Kg.According to the acute toxicity classification, Xianbei an ancient nationality in China's flower extract should true border innocuous substance.The results are shown in Table 1:
| Table 1 Xianbei an ancient nationality in China spends the acute toxicity test of water extract to Kunming mouse | |||||
| Group and dosage (g/Kgbw) | The mice sex is female, male | Mice quantity (only) | Reaction of animals n | Death toll (only) | LD 50(g/Kg·bw) |
| 7.50 15.00 30.00 60.00 7.50 15.00 30.00 60.00 | Male and female | 5 5 5 5 5 5 5 5 | The normal 1 Zheng Chang Zhengchang of the normal 1 Zheng Chang Zhengchang Zheng Chang Zhengchang Zheng of Zheng | 0 0 0 0 0 0 0 0 | ＞60.00 ＞60.00 |
4, Xianbei an ancient nationality in China's flower extract is to the influence of mice enterokinesia
4.1 influence to the small intestine movement of mice propulsion functions
Get 40 of Kunming mouses, be divided into four groups at random, behind the water supply fasting 24h, gavage normal saline and high dose (15.00g/Kgbw), middle dosage (7.00g/Kgbw), low dosage (3.75g/Kgbw) the flower extract 0.02ml/g of Xianbei an ancient nationality in China respectively, every mouse gavaging 0.2mL5% charcoal end arabic gum suspension after 20 minutes.Treat after 20 minutes that with dislocation method with sacrifice of animal, the taking-up the intestines and stomach of cutting open the belly immediately is tiled on the glass plate, measure displacement and the small intestinal total length (from pylorus to ileocecus) of charcoal end head end in intestinal tube, be calculated as follows the propelling percentage rate:
Charcoal end propelling rate=(charcoal end front end is to the distance/small intestinal total length of pylorus) * 100%
3.2 influence to atropine hydrochloride load mouse small intestine propulsion functions
Get 40 of Kunming mouses, be divided into four groups at random, behind the water supply fasting 24h, the atropine hydrochloride of 5min subcutaneous injection 0.12mg/kg before gavaging administration, all the other methods are the same.
Experimental result shows, high, medium and low dosage Xianbei an ancient nationality in China flower extract all has facilitation to mice in body intestinal propulsion function, and wherein the effect of high dose group is the strongest, to normal and atropine load mice intestinal progradation, with the normal saline group relatively, P＜0.05.And middle dosage group only compares P＜0.05 with the normal saline group in to the intestinal progradation of atropine load mice; Low dose group also has facilitation, but not statistically significant.See Table 2.
| Table 2 Xianbei an ancient nationality in China spends the influence of the water extracted immersing paste to normal mouse and atropine hydrochloride load mouse small intestine propulsion functions | |||
| Group and dosage (g/Kgbw) | Mice quantity | Small intestinal charcoal end propelling rate (%) | |
| Normal mouse | Atropine load mice | ||
| Normal saline group high dose group, (15.00) dosage group in, (7.50) low dose group, (3.75) | 10 10 10 10 | 52.71±6.93 63.41±7.22 * 56.82±7.50 54.20±7.13 | 56.24±6.88 71.82±7.66 * 68.39±7.38 * 63.75±8.42 |
5, Xianbei an ancient nationality in China's flower extract is to the blood fat influence of experimental hyperlipemia rat
56 Wistar rats are pressed the body weight random packet, every group 8, totally 7 groups, be followed successively by: A (blank group), B (hyperlipidemia model group), C (high lipid food+high dose group), D (high lipid food+Herb Gynostemmae Pentaphylli group), E (high lipid food+middle dosage group), F (high lipid food+low dose group), G (normal feedstuff+middle dosage group.Freely drink water.Except that A, G group, all the other respectively organize every afternoon all by Emulsion 10ml/kgd, irritate and feed high lipoprotein emulsion, press experimental design amount gastric infusion the morning, and matched group is irritated stomach equal-volume distilled water, and once a day, after continuous 28 days, fasting 12h can't help water after the last administration.Morning next day, the carotid artery blood-letting, separation of serum is used to detect the every index of blood fat.
At experimental session, the outward appearance of experimental group rat, behavioral activity, the mental status, appetite, the defecation and the fur colour of skin etc. there is no abnormal phenomena, show that Xianbei an ancient nationality in China's flower extract does not influence the normal growth of rat, and experimental hyperlipemia rat exists metabolism disorder of blood lipid, the normal matched group of TC (T-CHOL), TG (triglyceride) and the every index of LDL-C (low-density lipoprotein cholesterol) all is significantly improved, and the modeling success is described.The positive drug Herb Gynostemmae Pentaphylli total glycosides tablet has in various degree reduction effect to the every index of Serum TC, TG and LDL-C.Giving Xianbei an ancient nationality in China spends water extract after 28 days, high, medium and low dosage all can significantly reduce high fat Serum TC (P＜0.01), TG (P＜0.05), LDL-C (P＜0.01), and its effect for reducing fat has dose dependent, to Serum HDL-C (HDL-C) content, each group difference does not have significance, is steady statue.
Xianbei an ancient nationality in China's flower extract all has the reduction effect to normal rat fat TC, TG and the every index of LDL-C, wherein to TG (P＜0.05) effect significantly; HDL-C there is the rising effect, but compares not statistically significant, see Table 3 with the blank group:
| Table 3 Xianbei an ancient nationality in China spend water extract to the influence of hyperlipidemia rat and normal rat blood lipid level (χ ± s, n=8) | ||||
| Group and dosage (g/Kgbw) | TC (mmol/L) | TG (mmol/L) | LDL-C (mmol/L) | HDL-C (mmol/L) |
| A B C(15.00) D(0.05) E(7.50) F(3.75) G(7.50) | 1.78±0.14 ## 3.13±0.17 ** 1.70±0.08 ## 1.79±0.13 ## 1.82±0.12 ## 1.83±0.13 ## 1.74±0.07 ## | 0.63±0.12 0.71±0.16 0.40±0.04 *# 0.45±0.04 *# 0.42±0.06 *# 0.46±0.04 # 0.39±0.03 * | 0.37±0.08 ## 0.81±0.09 ** 0.34±0.04 ## 0.41±0.04 ## 0.43±0.04 ## 0.45±0.04 ## 0.35±0.08 ## | 0.97±0.14 0.83±0.13 1.03±0.11 # 0.96±0.11 0.96±0.13 0.96±0.12 1.01±0.09 # |
Through the aqueous extract pharmacological evaluation is shown, 1. really genus is nontoxic in the present invention, is attributable to integration of edible and medicinal herbs; 2. the present invention has the function of intestinal propulsion, can be aid digestion, regulate constipation; 3. the present invention can be used for blood fat reducing, reduces the body weight of obese rat, so can be used for fat-reducing.
Claims (7)
1, a kind of health product is characterized in that preparing digestant tea with the branch and leaf of Rosaceae Xianbei an ancient nationality in China flower plant.
2, a kind of health product is characterized in that the branch and leaf of Rosaceae Xianbei an ancient nationality in China flower plant prepare the tea of regulating constipation.
3, a kind of health product is characterized in that the branch and leaf of Rosaceae Xianbei an ancient nationality in China flower plant prepare the tea of blood fat reducing, fat-reducing.
4, the extract of Rosaceae Xianbei an ancient nationality in China flower plant branch and leaf prepares digestant medicine.
5, the medicine of the extract of Rosaceae Xianbei an ancient nationality in China flower plant branch and leaf preparation treatment constipation.
6, the extract of Rosaceae Xianbei an ancient nationality in China flower plant branch and leaf prepares the medicine of blood fat reducing.
7, the medicine of the extract of Rosaceae Xianbei an ancient nationality in China flower plant branch and leaf preparation fat-reducing.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188515A (en) * | 2011-04-24 | 2011-09-21 | 兰州大学 | Purpose of the plant Sibiraea angustata |
| CN101732441B (en) * | 2010-01-22 | 2012-03-07 | 北京师范大学 | Extract of effective part of sibiraea augustata(rehd.) hand-mazz for preventing adiposity and lowering hyperlipoidemia, preparation method and application thereof |
| CN102422943A (en) * | 2011-10-30 | 2012-04-25 | 左权县馨源丰商贸有限公司 | Rosa multiflora flower tea and production method thereof |
| CN102641352A (en) * | 2012-04-24 | 2012-08-22 | 杭州柳茶医药科技有限公司 | Sibiraea effective-part extract, preparation method and use thereof |
| CN103621742A (en) * | 2013-12-10 | 2014-03-12 | 中国科学院成都生物研究所 | Rose tea as well as preparation method and application thereof |
| CN108260815A (en) * | 2016-12-30 | 2018-07-10 | 西藏天麦力健康品有限公司 | It is a kind of have the function of reducing blood lipid, weight-reducing health food and preparation method thereof |
| CN109105891A (en) * | 2018-07-25 | 2019-01-01 | 甘肃奇正实业集团有限公司 | A kind of raising Xianbei an ancient nationality in China spends or the method for the aid digestion effect of Sibiraea angustata and obtained product and application |
-
2006
- 2006-03-02 CN CNB2006100419237A patent/CN100525791C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732441B (en) * | 2010-01-22 | 2012-03-07 | 北京师范大学 | Extract of effective part of sibiraea augustata(rehd.) hand-mazz for preventing adiposity and lowering hyperlipoidemia, preparation method and application thereof |
| CN102188515A (en) * | 2011-04-24 | 2011-09-21 | 兰州大学 | Purpose of the plant Sibiraea angustata |
| CN102188515B (en) * | 2011-04-24 | 2012-12-12 | 兰州大学 | Purpose of the plant Sibiraea angustata |
| CN102422943A (en) * | 2011-10-30 | 2012-04-25 | 左权县馨源丰商贸有限公司 | Rosa multiflora flower tea and production method thereof |
| CN102641352A (en) * | 2012-04-24 | 2012-08-22 | 杭州柳茶医药科技有限公司 | Sibiraea effective-part extract, preparation method and use thereof |
| CN103621742A (en) * | 2013-12-10 | 2014-03-12 | 中国科学院成都生物研究所 | Rose tea as well as preparation method and application thereof |
| CN108260815A (en) * | 2016-12-30 | 2018-07-10 | 西藏天麦力健康品有限公司 | It is a kind of have the function of reducing blood lipid, weight-reducing health food and preparation method thereof |
| CN109105891A (en) * | 2018-07-25 | 2019-01-01 | 甘肃奇正实业集团有限公司 | A kind of raising Xianbei an ancient nationality in China spends or the method for the aid digestion effect of Sibiraea angustata and obtained product and application |
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