CN101518595A - Medical composition with functions of lowering lipid, reducing fat and oxidation resistance and preparation method thereof - Google Patents
Medical composition with functions of lowering lipid, reducing fat and oxidation resistance and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a medical composition with functions of lowering lipid, reducing fat and oxidation resistance and a preparation method thereof. The composition is made from the following raw materials by weight ratio: 0.5 portion to 2.0 portions of gynostemma pentaphyllum extract, 0.5 portion to 3.0 portions of tuber fleeceflower root extract, 0.5 portion to 3.0 portions of kudzuvine root extract, 0.5 portion to 2.0 portions of green tea extract and 0.5 portion to 2.0 portions of hawthorn extract. The medical composition has obvious functions of lowering lipid, reducing fat and oxidation resistance, can effectively delay the process of aging and has actual curative effect, stable quality and safety and innocuity.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, belong to technical field of Chinese medicines with lowering blood-fat and reducing weight, anti-oxidation function.
Background technology
Along with improving constantly of people's living standard, the sickness rate of hyperlipemia presents the rising trend that significantly goes up.The absorption of saturated fatty acid, smoking and relevant disease such as bad life style, diabetes and inducements such as complication, medicine and the mental status such as drink all can increase the incidence rate of dyslipidemia in the meals.
Obesity belongs to the ciril disease of modern society, and along with growth in the living standard, involving in of immobilized animation and high calorie foods is to cause fat most important risk factor.The sickness rate of modern obesity presents significant ascendant trend, and rejuvenation trend is obvious, has become one of modern medicine most significant problems.Obesity has contained each crowd, each age level, and it is in close relations with hypertension, coronary heart disease, diabetes, osteoarthritis and some cancer etc., having a strong impact on teen-age normal growth grows, brought many worries for people's orthobiosis, and threaten to human health.
Old and feeble then go up in the life continuation process must experience physiological process, yet, anyone does not wish to allow the wheel in years take away once appearance, in today that people's living standard improves constantly, healthy, natural, young pursuit has been become the main flow that people pay close attention to, therefore, exploitation has the medicine of antioxidation, delaying senility function, will have better economic and social meaning.
Treatment for chronic disease, past is controlled by dialectical the executing of Traditional Chinese medical theory mostly, and recently, along with the modern continuous development of medicine, the progress of making a breakthrough property aspect the research of effective site, effective ingredient in natural drug, on the basis of China's traditional Chinese medicine theory, clinical experience, in conjunction with the modern study means, extraction exploitation effective site, effective ingredient are the new ways of drug research from natural drug.
Summary of the invention
One of purpose of the present invention is to provide a kind of determined curative effect, take safe pharmaceutical composition with lowering blood-fat and reducing weight, anti-oxidation function, said composition has significant functions of lowering blood-fat and reducing weight, and has significant anti-oxidation function, can effectively delay the body aging process, steady quality, safety non-toxic.
Two of purpose of the present invention is to provide this preparation of drug combination method.
The present invention is on the basis of clinical treatment experience for many years to the human body Simple Obesity, the ingredient that preferably has lowering blood-fat and reducing weight, antioxidation, through the pharmaceutical preparation that technology is made such as extracting, concentrate with fat-reducing, anti-oxidation function, clinical hyperlipemia, the obesity of being used for the treatment of, treating both the principal and secondary aspects of a disease, determined curative effect, and can effectively regulate free radical metabolism, suppress its infringement, delay the body aging process body.
Pharmaceutical composition with lowering blood-fat and reducing weight, anti-oxidation function provided by the invention is characterized in that said composition is to be made by following raw materials by weight proportions:
Herb Gynostemmae Pentaphylli extract 0.5~2.0 weight portion Radix Polygoni Multiflori extract 0.5~3.0 weight portion
Radix Puerariae extract 0.5~3.0 weight portion green tea extract 0.5~2.0 weight portion
Fructus Crataegi extract 0.5~2.0 weight portion
Further, on the basis that the above-mentioned raw materials medicine is formed, the weight proportion of the crude drug of pharmaceutical composition of the present invention can be adopted as especially:
Herb Gynostemmae Pentaphylli extract 10 weight portion Radix Polygoni Multiflori extracts 15 weight portions
Radix Puerariae extract 15 weight portion green tea extracts 10 weight portions
Fructus Crataegi extract 10 weight portions
Obesity mainly is because the disorder of body lipid absorption metabolic function, causing lipid gathers in a large number in vivo and forms, in the pharmaceutical composition of the present invention, Herb Gynostemmae Pentaphylli extract is through extracting by Herb Gynostemmae Pentaphylli, prepared such as concentrating forms, its main effective ingredient is a Herb Gynostemmae Pentaphylli total glycosides, Herb Gynostemmae Pentaphylli has the effect that spleen invigorating is regulated the flow of vital energy, modern pharmacological research is the result show, Herb Gynostemmae Pentaphylli can suppress adipose cell and produce free fatty and synthetic neutral fat, has significant effect for reducing fat, can significantly reduce serum total cholesterol, triglyceride, low density lipoprotein, LDL (LDL-ch) and very low density lipoprotein (VLDL) (VDL-ch) content, high density lipoprotein increasing (the ratio of HDL/LDL, simultaneously, Herb Gynostemmae Pentaphylli extract has significant raising superoxide dismutase (SOD) activity, the antagonism brain, the heart, the liver lipofuscin increase collection, remove the effect of active oxygen and human body immunity improving function; Radix Polygoni Multiflori has the effect of liver and kidney tonifying, Radix Polygoni Multiflori extract is that Radix Polygoni Multiflori is through water extraction, concentrate and be prepared from, has obvious cholesterol reducing, triglyceride, beta lipoprotein content, reduce lipidosis, increase the effect of serum high-density LP cholesterol, the contained anthraquinone effective constituents of Radix Polygoni Multiflori can promote enterokinesia, suppress the again absorption of cholesterol at intestinal, and can promote cholesterol metabolism, hexichol alkene constituents in the Radix Polygoni Multiflori also can significantly reduce the total cholesterol level in the serum, and simultaneously, Radix Polygoni Multiflori has significant delaying senility function, pharmacological research proves, Radix Polygoni Multiflori can significantly increase protein content in the brain regulating liver-QI, can reduce MDA content in the brain regulating liver-QI, strengthens brain regulating liver-QI SOD activity, can obviously suppress monoamine oxidase-B in the brain regulating liver-QI (MAO-B) activity, increase 5-HT in the cerebral tissue, NE and DA content; Contained puerarin in the Radix Puerariae extract has the effect that reduces serum TG and LDL-C, but and increased SOD, reduce MDA, and can raise serum NO level, NOS and PGI2, blood lipid regulation, antioxidant activity had; The main effective ingredient of green tea extract is a polyphenol compound, can reduce the differentiation and the propagation of adipose cell, lipogenesis, fat mass, body weight, fat absorption, plasma tg, FFA, cholesterol, glucose, insulin and leptin, simultaneously, increase beta oxidation and themogenesis, clinical research is found, green tea can reduce body weight and body fat, increase fat oxidation and themogenesis simultaneously, simultaneously, Polyphenols composition in the green tea has significant antioxidant role, can improve superoxide dismutase (SOD) activity, effectively suppress and remove interior free yl, thereby suppress the infringement of senescence-factor body; Flavonoid substances in the Fructus Crataegi can reduce serum TC, TG level, can obviously increase the concentration of HDL and subfraction HD2 thereof, clinical treatment hyperlipemia definite effect.
Herb Gynostemmae Pentaphylli extract, Radix Polygoni Multiflori extract, Radix Puerariae extract, green tea extract, Fructus Crataegi extract share among the present invention, can reduce the absorption of exogenous lipid on the one hand, mainly are the absorptions that reduces cholesterol; Can reduce the synthetic of endogenous lipid on the one hand; Can promote the transhipment and the drainage of lipid on the one hand; The scalable lipid metabolism reaches blood fat reducing, slimming effect on the one hand.
Because old and feeble all cards of hyperlipemia, obesity and body are the secular pathology and the physiological reaction of human body, cause of disease complexity is selected for use the present invention to treat and is had many target spots, the little advantage of side effect, and therapeutic effect is definite, promptly do not have addiction, can not produce drug dependence yet.
The present invention realizes by following preparation method:
Get Herb Gynostemmae Pentaphylli extract, Radix Polygoni Multiflori extract, Radix Puerariae extract, green tea extract, Fructus Crataegi extract mix homogeneously, formulation method adds suitable pharmaceutic adjuvant routinely, is processed into clinical acceptable forms, as tablet, capsule, soft capsule etc.
Extract is realized by following preparation method among the present invention:
(1) Herb Gynostemmae Pentaphylli extract preparation method
Get Herb Gynostemmae Pentaphylli powder and be broken into coarse powder, with 6~10 times of amount 50%~80% alcohol reflux 2~3 times, each 2~3 hours, extract pure liquid and merge, filter, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.10~1.20 clear paste, spray drying, promptly.
(2) Radix Polygoni Multiflori extract preparation method
Get Radix Polygoni Multiflori powder and be broken into coarse powder, decoct 2~3 times with 8~12 times of water gagings, each 1~3 hour, decocting liquid merged, and filtered, and filtrate is evaporated to relative density under 50~70 ℃ of conditions be 1.10~1.20 clear paste, spray drying, promptly.
(3) Radix Puerariae extract preparation method
Get powder of Radix Puerariae and be broken into coarse powder, with 6~10 times of amount 60~95% alcohol reflux 2~3 times, each 2~3 hours, extract pure liquid and merge, filter, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.10~1.20 clear paste, spray drying, promptly.
(4) green tea extract preparation method
Get green tea powder and be broken into coarse powder, with 6~10 times of amount 60~95% alcohol reflux 2~3 times, each 2~3 hours, extract pure liquid and merge, filter, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.10~1.20 clear paste, spray drying, promptly.
(5) Fructus Crataegi extract preparation method
Get Fructus Crataegi powder and be broken into coarse powder, 6~10 times of amount 60~95% alcohol reflux 2~3 times, each 2~4, extract pure liquid and merge, filter, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.10~1.20 clear paste, spray drying, promptly.
For guaranteeing the Chinese crude drug extract of the present invention and the quality of the pharmaceutical preparations, formulated the quality standard of Herb Gynostemmae Pentaphylli extract, Radix Polygoni Multiflori extract, Radix Puerariae extract, green tea extract and Fructus Crataegi extract, stipulated the content limit of main effective ingredient in the extract, and the method for quality control of pharmaceutical preparation of the present invention studied, formulated method of quality control stable, easy, favorable reproducibility.
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.
Embodiment 1
(1) gets Herb Gynostemmae Pentaphylli powder and be broken into coarse powder,, extract pure liquid and filter with 10 times of amount 60% alcohol reflux 2 hours; Medicinal residues added 8 times of amount 60% alcohol reflux 2 hours, extracted pure liquid and filtered; Medicinal residues add 8 times of amount 60% alcohol reflux 2 hours again, extract pure liquid and merge, filter, and decompression filtrate recycling ethanol and to be concentrated into relative density be 1.15 clear paste, spray drying, standby;
(2) get Radix Polygoni Multiflori powder and be broken into coarse powder, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1 hour, and decocting liquid filters; Medicinal residues add 8 times of water gagings again and decocted 1 hour, and decocting liquid merges, and filter, and filtrate is evaporated to relative density under 55 ℃ of conditions be 1.10 clear paste, and spray drying is standby;
(3) get powder of Radix Puerariae and be broken into coarse powder,, extract pure liquid and filter with 8 times of amount 85% alcohol reflux 3 hours; Medicinal residues added 8 times of amount 85% alcohol reflux 2 hours, extracted pure liquid and filtered; Medicinal residues add 8 times of amount 85% alcohol reflux 2 hours again, extract pure liquid and merge, filter, and decompression filtrate recycling ethanol and to be concentrated into relative density be 1.15 clear paste, spray drying, standby;
(4) get green tea powder and be broken into coarse powder,, extract pure liquid and filter with 10 times of amount 80% alcohol reflux 2 hours; Medicinal residues add 8 times of amount 80% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount 80% alcohol reflux 2 hours again, extract pure liquid and merge, filter, and decompression filtrate recycling ethanol and to be concentrated into relative density be 1.15 clear paste, spray drying, standby;
(5) get Fructus Crataegi powder and be broken into coarse powder,, extract pure liquid and filter with 10 times of amount 85% alcohol reflux 4 hours; Medicinal residues add 8 times of amount 85% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount 85% alcohol reflux 2 hours again, extract pure liquid and merge, filter, and decompression filtrate recycling ethanol and to be concentrated into relative density be 1.10 clear paste, spray drying, standby;
(6) get Herb Gynostemmae Pentaphylli extract 50g, Radix Polygoni Multiflori extract 75g, Radix Puerariae extract 75g, green tea extract 50g, Fructus Crataegi extract 50g, be ground into fine powder, mix homogeneously, add starch 75g, magnesium stearate 25g, mix homogeneously, packing, check gets 1000 of capsules.
Embodiment 2
(1) gets Herb Gynostemmae Pentaphylli powder and be broken into coarse powder,, extract pure liquid and filter with 8 times of amount 50% alcohol reflux 3 hours; Medicinal residues added 8 times of amount 50% alcohol reflux 2 hours, extracted pure liquid and filtered; Medicinal residues add 8 times of amount 50% alcohol reflux 2 hours again, extract pure liquid and merge, filter, and decompression filtrate recycling ethanol and to be concentrated into relative density be 1.15 clear paste, spray drying, standby;
(2) get Radix Polygoni Multiflori powder and be broken into coarse powder, decocted 2 hours with 10 times of water gagings, decocting liquid filters; Medicinal residues add 8 times of water gagings and decocted 1 hour, and decocting liquid filters; Medicinal residues add 8 times of water gagings again and decocted 1 hour, and decocting liquid merges, and filter, and filtrate is evaporated to relative density under 60 ℃ of conditions be 1.15 clear paste, and spray drying is standby;
(3) get powder of Radix Puerariae and be broken into coarse powder,, extract pure liquid and filter with 10 times of amount 80% alcohol reflux 3 hours; Medicinal residues added 8 times of amount 80% alcohol reflux 2 hours, extracted pure liquid and filtered; Medicinal residues add 8 times of amount 80% alcohol reflux 2 hours again, extract pure liquid and merge, filter, and decompression filtrate recycling ethanol and to be concentrated into relative density be 1.15 clear paste, spray drying, standby;
(4) get green tea powder and be broken into coarse powder,, extract pure liquid and filter with 8 times of amount 85% alcohol reflux 2 hours; Medicinal residues add 8 times of amount 85% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount 85% alcohol reflux 2 hours again, extract pure liquid and merge, filter, and decompression filtrate recycling ethanol and to be concentrated into relative density be 1.15 clear paste, spray drying, standby;
(5) get Fructus Crataegi powder and be broken into coarse powder,, extract pure liquid and filter with 8 times of amount 75% alcohol reflux 3 hours; Medicinal residues add 8 times of amount 75% alcohol reflux 3 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount 75% alcohol reflux 2 hours again, extract pure liquid and merge, filter, and decompression filtrate recycling ethanol and to be concentrated into relative density be 1.15 clear paste, spray drying, standby;
(6) get Herb Gynostemmae Pentaphylli extract 30g, Radix Polygoni Multiflori extract 45g, Radix Puerariae extract 45g, green tea extract 30g, Fructus Crataegi extract 30g, pulverize, cross 120 mesh sieves, mix homogeneously is made suspended matter with vegetable oil, Cera Flava by 1:1:0.02;
(7) get gelatin, G ﹠ W is made rubber with the ratio of 1:0.35:0.9;
(8) suspended matter is pressed into 1000 soft capsules.
Claims (3)
1, the pharmaceutical composition that has lowering blood-fat and reducing weight, anti-oxidation function is characterized in that said composition is to be made by following raw materials by weight proportions:
Herb Gynostemmae Pentaphylli extract 0.5~2.0 weight portion Radix Polygoni Multiflori extract 0.5~3.0 weight portion
Radix Puerariae extract 0.5~3.0 weight portion green tea extract 0.5~2.0 weight portion
Fructus Crataegi extract 0.5~2.0 weight portion.
2, the pharmaceutical composition that has lowering blood-fat and reducing weight, anti-oxidation function according to claim 1 is characterized in that the weight proportion of this pharmaceutical composition can be adopted as especially:
Herb Gynostemmae Pentaphylli extract 10 weight portion Radix Polygoni Multiflori extracts 15 weight portions
Radix Puerariae extract 15 weight portion green tea extracts 10 weight portions
Fructus Crataegi extract 10 weight portions
3, preparation of drug combination method as claimed in claim 1 or 2 is characterized in that this method is:
Get Herb Gynostemmae Pentaphylli extract, Radix Polygoni Multiflori extract, Radix Puerariae extract, green tea extract, Fructus Crataegi extract mix homogeneously, formulation method adds suitable pharmaceutic adjuvant routinely, is processed into clinical acceptable forms, as tablet, capsule, soft capsule etc.
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101664481B (en) * | 2009-09-09 | 2011-03-16 | 济南宏济堂制药有限责任公司 | Health care product with effects of enhancing immunity and reducing lipid and preparation method thereof |
CN102008103A (en) * | 2010-10-21 | 2011-04-13 | 铜陵市松马食品包装机械制造有限责任公司 | Health care beverage and preparation method thereof |
CN102342499A (en) * | 2010-07-30 | 2012-02-08 | 陕西安康秦东魔芋食品有限公司 | Health food with auxiliary blood sugar and blood lipid lowering functions |
CN103251043A (en) * | 2012-03-23 | 2013-08-21 | 山东德圣医药科技有限公司 | Auxiliary hypolipidemic health-care food |
CN105832851A (en) * | 2016-05-31 | 2016-08-10 | 新疆环拓生物科技有限公司 | Healthcare traditional Chinese medicine preparation for weight loss |
CN106176440A (en) * | 2016-08-25 | 2016-12-07 | 江苏天晟药业股份有限公司 | There is Chinese medicine composition of collaborative antioxidation and its preparation method and application |
CN107551065A (en) * | 2016-07-01 | 2018-01-09 | 捷通国际有限公司 | The composition and application method based on plant for body weight control |
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2008
- 2008-02-28 CN CN200810101178A patent/CN101518595A/en active Pending
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101664481B (en) * | 2009-09-09 | 2011-03-16 | 济南宏济堂制药有限责任公司 | Health care product with effects of enhancing immunity and reducing lipid and preparation method thereof |
CN102342499A (en) * | 2010-07-30 | 2012-02-08 | 陕西安康秦东魔芋食品有限公司 | Health food with auxiliary blood sugar and blood lipid lowering functions |
CN102008103A (en) * | 2010-10-21 | 2011-04-13 | 铜陵市松马食品包装机械制造有限责任公司 | Health care beverage and preparation method thereof |
CN102008103B (en) * | 2010-10-21 | 2013-02-20 | 铜陵市松马食品包装机械制造有限责任公司 | Health care beverage and preparation method thereof |
CN103251043A (en) * | 2012-03-23 | 2013-08-21 | 山东德圣医药科技有限公司 | Auxiliary hypolipidemic health-care food |
CN105832851A (en) * | 2016-05-31 | 2016-08-10 | 新疆环拓生物科技有限公司 | Healthcare traditional Chinese medicine preparation for weight loss |
CN107551065A (en) * | 2016-07-01 | 2018-01-09 | 捷通国际有限公司 | The composition and application method based on plant for body weight control |
CN106176440A (en) * | 2016-08-25 | 2016-12-07 | 江苏天晟药业股份有限公司 | There is Chinese medicine composition of collaborative antioxidation and its preparation method and application |
CN107669763A (en) * | 2017-08-17 | 2018-02-09 | 福建海兴保健食品有限公司 | A kind of compound blood fat reducing health products of sea grass polysaccharide and preparation method thereof |
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