CN108185412A - A kind of auxiliary blood-fat reducing composition and its preparation method and application - Google Patents
A kind of auxiliary blood-fat reducing composition and its preparation method and application Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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Abstract
The present invention relates to a kind of auxiliary blood-fat reducing compositions and its preparation method and application, and the auxiliary blood-fat reducing composition includes the raw material of following parts by weight proportioning：2~6 parts of pueraria lobata, 2~4 parts of Radix Angelicae Sinensis, 1~3 part of Rhizoma Chuanxiong, 0.5~1.5 part of Radix Notoginseng, 0.5~1.5 part of Radix Glycyrrhizae, 3~7 parts of gynostemma pentaphylla.The auxiliary blood-fat reducing composition by the raw material it is soaking, decoct, concentrate, dry, crush, mix.The ratio that auxiliary blood-fat reducing composition provided by the present invention passes through preferred Yi Shang ingredient, make to act synergistically between each ingredient, by tonifying the liver and kidney, invigorating the spleen for eliminating dampness, dispersing stagnated hepatoqi, promoting blood circulation and removing blood stasis, clearing away heat and loosing the bowels, the measures such as eliminate indigestion and phlegm improve blood fat, the effect of auxiliary reducing blood lipid can be preferably played, improves blood lipid.Tea bag is made in above-mentioned auxiliary blood-fat reducing composition, user is supplied to take in the form of health products, patient is made blood fat can be made adjusted in daily drinking period, so as to play the role of assisting reducing blood lipid.
Description
Technical field
The present invention relates to technical field of health care food, more particularly to a kind of auxiliary blood-fat reducing composition and preparation method thereof and
Using.
Background technology
Hyperlipidemia is a kind of common disease, refers to that blood lipid level is excessively high, some can directly be caused to seriously endanger health
Disease, such as atherosclerosis, coronary heart disease, pancreatitis, cerebral thrombus, cerebral hemorrhage, be cerebral apoplexy, coronary heart disease, myocardial infarction,
Cardiac sudden death is independent and important risk factor, threat to life.Modern is since living standard improves, and feed is fatty and courage is consolidated
Alcohol group food is excessive, and hyperlipidemia incidence improves year by year.The external symptom of general hyperlipidemia show as more dizziness, spiritlessness and weakness,
Insomnia forgetfulness, extremity numbness, uncomfortable in chest, palpitaition etc. have seriously affected the quality of life of people with hyperlipidemia.In traditional Chinese medicine, according to
Its etiology and pathogenesis and clinical manifestation can belong to the range of turbid phlegm, blood stasis, dizziness, apoplexy etc..The traditional Chinese medical science thinks the hair of hyperlipemia
It is raw include internal cause and external cause two in terms of, wherein external cause is mainly the product of overfeeding greasy and surfeit flavour, delicious food, and property sweet in flavor is delayed, it is slow then
Temper is stagnant, it is impossible to change turbid and give birth to phlegm wet；Internal cause is visceral dysfunction, and failure of qi transforming fluid, then phlegm is turbid stops up stagnant, functional activity of QI being not smooth, train of thought
Stasis blocking.Although existing hypolipidemic can change serology index, the internal cause for inducing hyperlipidemia can not be eliminated, human body is to drop
Blood fat medicine can generate dependence.
Invention content
For existing hypolipidemic only from change serology index, cannot eliminate induce hyperlipidemia internal cause the problem of, this hair
It is bright that a kind of auxiliary blood-fat reducing composition is provided.
And the present invention also provides a kind of preparation methods for assisting blood-fat reducing composition.
And the present invention also provides a kind of tea bags.
And the present invention also provides a kind of applications for assisting blood-fat reducing composition as auxiliary blood fat reducing health products.
To achieve the above object of the invention, the embodiment of the present invention employs following technical solution：
A kind of auxiliary blood-fat reducing composition includes the raw material of following parts by weight proportioning：2~6 parts of pueraria lobata, Radix Angelicae Sinensis 2~4
Part, 1~3 part of Rhizoma Chuanxiong, 0.5~1.5 part of Radix Notoginseng, 0.5~1.5 part of Radix Glycyrrhizae, 3~7 parts of gynostemma pentaphylla.
Relative to the prior art, auxiliary blood-fat reducing composition provided by the present invention is by preferably comprising the upper of special ratios
State component, make to act synergistically between each ingredient, by tonifying the liver and kidney, invigorating the spleen for eliminating dampness, dispersing stagnated hepatoqi, promoting blood circulation and removing blood stasis, clearing away heat and loosing the bowels,
The measures of grade that eliminate indigestion and phlegm improve blood fat, and the effect of auxiliary reducing blood lipid is played in terms of the internal cause for inducing hyperlipidemia is eliminated,
Improve blood lipid.
The present invention also provides a kind of preparation method of above-mentioned auxiliary blood-fat reducing composition, the auxiliary blood-fat reducing compositions
By the raw material it is soaking, decoct, concentrate, dry, crush, mix.
The preparation method process increases the time of contact of solid material and water by impregnating process, improve effectively into
The extraction effect divided；By decocting process, the bioavilability for decocting active ingredient in raw material is significantly improved, it is easier to absorb
And play effect；Solvent in solution is reduced by concentration technology, the time of follow-up drying process can be improved, improves production effect
Rate；Concentrate is made to become solid by drying process, so as to be conducive to be made a variety of oral products.
The present invention also provides a kind of tea bag, the content of the tea bag is by above-mentioned auxiliary blood-fat reducing composition and tax
Shape agent is made.
Tea bag is convenient to take as a kind of health products form, can improve the compliance of user, and promote to make indirectly
User drinks more water, and then multiple rows of urine, exclusion toxins in body, so as to preferably play the effect of auxiliary reducing blood lipid.
The present invention also provides application of the above-mentioned auxiliary blood-fat reducing composition as auxiliary blood fat reducing health products.
The present invention is supplied to user by the way that above-mentioned auxiliary blood-fat reducing composition is made tea bag in the form of health products
It takes, patient is made blood fat can be made adjusted in daily drinking period, so as to play the role of assisting reducing blood lipid.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, below in conjunction with specific embodiment, to this
Invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, not
For limiting the present invention.
The embodiment of the present invention provides a kind of auxiliary blood-fat reducing composition, includes the raw material of following parts by weight proportioning：Pueraria lobata 2
~6 parts, 2~4 parts of Radix Angelicae Sinensis, 1~3 part of Rhizoma Chuanxiong, 0.5~1.5 part of Radix Notoginseng, 0.5~1.5 part of Radix Glycyrrhizae, 3~7 parts of gynostemma pentaphylla.
Relative to the prior art, the ratio provided by the present invention for assisting blood-fat reducing composition by preferred Yi Shang ingredient,
Make to act synergistically between each ingredient, by tonifying the liver and kidney, invigorating the spleen for eliminating dampness, dispersing stagnated hepatoqi, promoting blood circulation and removing blood stasis, clearing away heat and loosing the bowels, digestion-promoting
The measures such as phlegm improve blood fat, and the effect of auxiliary reducing blood lipid is played in terms of the internal cause for inducing hyperlipidemia is eliminated, and improve and suffer from
Person's blood lipid level.
Pueraria lobata is sweet in flavor, pungent, cool in nature, returns spleen, stomach, lung channel.Pharmacological property rises floating, energy sending up the lucid yang, inspires on the taste gas of sun clearly
It rises；Acrid flavour row dissipates, can clearing and activating the channels and collaterals.With strand blue phase 5, can enhance replenish qi to invigorate the spleen, the work(of sending up the lucid yang.Pueraria lobata is in the present invention
With for monarch drug in a prescription in the auxiliary blood-fat reducing composition provided.
Radix Angelicae Sinensis is sweet in flavor, pungent, warm-natured, Return liver, the heart, the spleen channel.《Japan hanako materia medica》It is claimed " to cure mainly a wind cutting, all blood mend one
Qie Lao breaks extravesated blood, supports new blood and main Disorder addictions.”《Jing Yue's complete work book on Chinese herbal medicine is just》Cloud：" Radix Angelicae Sinensis, it is sweet in flavor and weigh, therefore can specially enrich blood,
Its gas is light and pungent, thus again can promoting circulation of blood, bowl spares has, there is benefit in row, the gas medicine in sincere blood, also the panacea in blood." bowl spares has
Row has a benefit in row, promoting circulation of blood not blood trouble.Have effects that good enrich blood, invigorate blood circulation.Pueraria lobata, Radix Angelicae Sinensis enhance dredging collateral promoting blood circulation and removing blood stasis with using
Work(, Radix Angelicae Sinensis it is provided by the present invention auxiliary blood-fat reducing composition in be used as ministerial drug.
Rhizoma Chuanxiong acrid flavour, warm-natured, Return liver, courage, pericardium channel.《Collected statements on the herbal foundation》Say its " the uplink head, lower menstruation regulating water, in open it is strongly fragrant
It ties, gas medicine in blood.Tasting is made by Radix Angelicae Sinensis, and Fei Zhi blood is active, and controls gas also god tests." there is blood-activating and qi-promoting.Gas row
Then blood, Rhizoma Chuanxiong and Radix Notoginseng, pueraria lobata, Radix Angelicae Sinensis phase 5, can enhance the work(of dredging collateral promoting blood circulation and removing blood stasis.Rhizoma Chuanxiong is provided by the present invention auxiliary
It helps and is used as adjutant in blood-fat reducing composition.
Radix Notoginseng is sweet in flavor, slight bitter, warm-natured, Return liver, stomach.《Chinese Medicine voluminous dictionary》It records：" Radix Notoginseng function is enriched blood, stasis eliminatings
Damage, hemostasis nosebleed, can lead to can mend, and effect is most good, be the most precious person in prescription.Radix Notoginseng eats it raw, and stasis eliminatings life is new, detumescence ding-tong, and
There is hemostasis not stay hemostasis, the advantages of new is not hindered in promoting circulation of blood；Ripe clothes can help be healthy and strong." Radix Notoginseng has good work(promoting blood circulation and removing blood stasis.Radix Notoginseng
With gynostemma pentaphylla with use, make gas foot and blood is unobstructed, tonifying Qi promoting circulation of blood, disperse blood stasis and dredge collateral.Radix Notoginseng is in auxiliary drop blood provided by the present invention
It is used as monarch drug in a prescription in oil/fat composition.
Radix Glycyrrhizae is sweet in flavor, mild-natured, the thoughts of returning home, lung, spleen, stomach.《Book on Chinese herbal medicine is just》Claiming it, " taste to property that is sweet, must neutralizing has and adjusts benefit
Work(." have invigorate the spleen and benefit qi, eliminating the phlegm, coordinating the drug actions of a prescription work(.Radix Glycyrrhizae and gynostemma pentaphylla, the same use of pueraria lobata, performance can be assisted to replenish qi to invigorate the spleen,
The work(of sending up the lucid yang, and energy coordinating the drug actions of a prescription are used as making medicine in auxiliary blood-fat reducing composition provided by the present invention.
Gynostemma pentaphylla bitter, micro-sweet, cool in nature, return lung, spleen, kidney channel.《Chinese Clinical Chinese Materia Medica》Say its " strengthening the spleen and replenishing qi.”《Face
Bed Chinese medicine dictionary》Calling its energy, " invigorating the spleen qi-regulating, qi and activate blood circulation promote the production of body fluid to quench thirst, detoxification and promoting urination." have strengthening the spleen and replenishing qi, clearing heat and eliminating phlegm it
Work(has the good reputation of " south ginseng ", and tonifying Qi effect is notable, available for physically weak weak, hyperlipidemia etc..Gynostemma pentaphylla is in institute of the present invention
It is used as monarch drug in a prescription in the auxiliary blood-fat reducing composition of offer.
Hyperlipidemia morbidity is in the deficient of liver,spleen,kidney, and phlegm-blood stasis is to mark, asthenia in origin and asthenia in superficiality, simulataneous insufficiency and excessive.The present invention takes benefit
Liver and kidney benefiting, dispersing stagnated hepatoqi, promoting blood circulation and removing blood stasis, clearing away heat and loosing the bowels, eliminates indigestion and phlegm to be improved at invigorating the spleen for eliminating dampness, and QI invigorating is with promoting circulation of blood, from
And the turbid lipid-loweringing of having the function that.There is no incompatibility in auxiliary blood-fat reducing composition provided by the present invention, it is safe and effective,
For Hyperlipidemia and belong to qi deficiency to blood stasis, turbid fat accumulates long-pending crowd, can effectively play auxiliary reducing blood lipid healthcare function.
The embodiment of the present invention also provides a kind of preparation method of above-mentioned auxiliary blood-fat reducing composition, the auxiliary reducing blood lipid group
Close object by the raw material it is soaking, decoct, concentrate, dry, crush, mix.
The preparation method process increases the time of contact of solid material and water by impregnating process, improve effectively into
The extraction effect divided；By decocting process, the bioavilability for decocting active ingredient in raw material is significantly improved, it is easier to absorb
And play effect；Solvent in solution is reduced by concentration technology, the time of follow-up drying process can be improved, improves production effect
Rate；Concentrate is made to become solid by drying process, so as to be conducive to be made a variety of oral products.
Specifically, above-mentioned preparation method specifically includes following steps：
Step a, each raw material components are weighed by raw material proportioning, pueraria lobata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Radix Glycyrrhizae is soaked, decocted
It boils；
Step b, it filters, water is added into filtrate, decoct；Repeat this step 1~2 time；
Step c, merging filtrate, concentration, dry, crushing；
Step d, gynostemma pentaphylla is sterilized, crushed；
Step e, step c products therefroms with step d products therefroms are mixed, oral products is made..
It is further preferred that the quality for adding water described in step a and step b is 8~12 times of quality of material, water foot
To be impregnated with raw material components, and excessively dilute solution, extension subsequent concentration and the time of drying will not be made due to water is excessive；In step a
Described to impregnate to impregnate 1.5~2.5 hours, the bulk pharmaceutical chemicals by immersion are easier to be extracted；It is decocted described in step a and step b
It boiling to decoct 1.5~2.5 hours, preferred decocting time can make the active ingredient in bulk pharmaceutical chemicals be fully extracted out, when
Between it is too short, extract insufficient, cause the waste of raw material, overlong time can't significantly improve recovery rate, but when can extend production
Between, increase production cost.
It is further preferred that sterilizing described in step c sterilizes for 60Coradiation, irradiation dose is 3.5~4.5kGy.Co 60
, can be with desinsection, fresh-keeping, sprout inhibition, sterilizing with very strong penetration power, and noresidue after irradiating can be killed in gynostemma pentaphylla
Microorganism, extend its shelf-life.The too low then sterilization effect of irradiation dose is poor, and irradiation dose is excessively high, it is possible that generating other pairs
Product.
It is further preferred that concentration described in step c is is concentrated under reduced pressure, temperature is 55~75 DEG C, the drying is decompression
Dry, temperature is 55~65 DEG C, is concentrated under reduced pressure and is dried under reduced pressure within the scope of preferred temperature, can improve dry effect
Rate saves production cost.
It is further preferred that being crushed described in step c to be crushed to 60~100 mesh sieve, crushed described in step d as powder
Be broken to 60~100 mesh sieve, preferred range of being sieved can ensure that raw material has higher specific surface area, make in raw material it is effective into
Divide and be easier to be extracted or release, so as to play preferably auxiliary effect for reducing blood fat.
The embodiment of the present invention also provides a kind of tea bag, and the content of the tea bag is by above-mentioned auxiliary blood-fat reducing composition
It is made with excipient.Tea bag is convenient to take as a kind of health products form, can improve the compliance of user, and indirectly
User is promoted to drink more water, and then multiple rows of urine, exclusion toxins in body, so as to preferably play the effect of auxiliary reducing blood lipid.
The embodiment of the present invention also provides application of the above-mentioned auxiliary blood-fat reducing composition as auxiliary blood fat reducing health products.
In order to better illustrate embodiment of the present invention, illustrated below by embodiment is further.
Embodiment 1
An embodiment of the present invention provides a kind of auxiliary blood-fat reducing compositions, include the raw material of following parts by weight proportioning：Pueraria lobota
2 parts of root, 2 parts of Radix Angelicae Sinensis, 1 part of Rhizoma Chuanxiong, 0.5 part of Radix Notoginseng, 0.5 part of Radix Glycyrrhizae, 3 parts of gynostemma pentaphylla.
Preparation method：
Step a, each raw material components are weighed by raw material proportioning, pueraria lobata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Radix Glycyrrhizae is added into 8 times of quality
Water impregnates 1.5 hours, decocts 1.5 hours；
Step b, it filters, the water of 8 times of quality is added into filtrate, decoct 1.5 hours；Repeat this step 2 times；
Step c, merging filtrate, 55 DEG C of reduced pressures, 55 DEG C are dried under reduced pressure, and crushing sieves with 100 mesh sieve；
Step d, gynostemma pentaphylla is sterilized with 60Coradiation, irradiation dose 3.5kGy, crushing sieves with 100 mesh sieve；
Step e, step c products therefroms with step d products therefroms are mixed, adds in 85% mass concentration, mix powder
The ethyl alcohol softwood of quality 30% crosses 20 mesh sieve series grains, 55 DEG C dry), tea bag, every bag of 6g is made in 20 mesh sieve whole grain.
Application method：
Tea bag is placed in 80 DEG C or more hot water after impregnating 15 minutes and drunk, can brewed repeatedly 3~7 times.
Embodiment 2
An embodiment of the present invention provides a kind of auxiliary blood-fat reducing compositions, include the raw material of following parts by weight proportioning：Pueraria lobota
3 parts of root, 2.5 parts of Radix Angelicae Sinensis, 1.5 parts of Rhizoma Chuanxiong, 0.8 part of Radix Notoginseng, 0.8 part of Radix Glycyrrhizae, 4 parts of gynostemma pentaphylla.
Preparation method：
Step a, each raw material components are weighed by raw material proportioning, pueraria lobata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Radix Glycyrrhizae is added into 9 times of quality
Water impregnates 1.8 hours, decocts 1.8 hours；
Step b, it filters, the water of 9 times of quality is added into filtrate, decoct 1.8 hours；Repeat this step 2 times；
Step c, merging filtrate, 60 DEG C of reduced pressures, 60 DEG C are dried under reduced pressure, and crushing sieves with 100 mesh sieve；
Step d, gynostemma pentaphylla is sterilized with 60Coradiation, irradiation dose 3.5kGy, crushing sieves with 100 mesh sieve；
Step e, step c products therefroms with step d products therefroms are mixed, adds in 85% mass concentration, mix powder
The ethyl alcohol softwood of quality 30% crosses 20 mesh sieve series grains, 55 DEG C dry), tea bag, every bag of 6g is made in 20 mesh sieve whole grain.
Application method：
Tea bag is placed in 80 DEG C or more hot water after impregnating 15 minutes and drunk, can brewed repeatedly 3~7 times.
Embodiment 3
An embodiment of the present invention provides a kind of auxiliary blood-fat reducing compositions, include the raw material of following parts by weight proportioning：Pueraria lobota
4 parts of root, 3 parts of Radix Angelicae Sinensis, 2 parts of Rhizoma Chuanxiong, 1 part of Radix Notoginseng, 1 part of Radix Glycyrrhizae, 5 parts of gynostemma pentaphylla.
Preparation method：
Step a, each raw material components are weighed by raw material proportioning, pueraria lobata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Radix Glycyrrhizae is added into 10 times of quality
Water impregnates 2 hours, decocts 2 hours；
Step b, it filters, the water of 10 times of quality is added into filtrate, decoct 2 hours；Repeat this step 1 time；
Step c, merging filtrate, 60 DEG C of reduced pressures, 60 DEG C are dried under reduced pressure, and crushed 80 mesh sieve；
Step d, gynostemma pentaphylla is sterilized with 60Coradiation, irradiation dose 4kGy crushed 80 mesh sieve；
Step e, step c products therefroms with step d products therefroms are mixed, adds in 85% mass concentration, mix powder
The ethyl alcohol softwood of quality 30% crosses 20 mesh sieve series grains, 55 DEG C dry), tea bag, every bag of 6g is made in 20 mesh sieve whole grain.
Application method：
Tea bag is placed in 80 DEG C or more hot water after impregnating 15 minutes and drunk, can brewed repeatedly 3~7 times.
Embodiment 4
An embodiment of the present invention provides a kind of auxiliary blood-fat reducing compositions, include the raw material of following parts by weight proportioning：Pueraria lobota
5 parts of root, 3.5 parts of Radix Angelicae Sinensis, 2.5 parts of Rhizoma Chuanxiong, 1.2 parts of Radix Notoginseng, 1.2 parts of Radix Glycyrrhizae, 6 parts of gynostemma pentaphylla.
Preparation method：
Step a, each raw material components are weighed by raw material proportioning, pueraria lobata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Radix Glycyrrhizae is added into 11 times of quality
Water impregnates 2.2 hours, decocts 2.2 hours；
Step b, it filters, the water of 11 times of quality is added into filtrate, decoct 2.2 hours；Repeat this step 1 time；
Step c, merging filtrate, 65 DEG C of reduced pressures, 65 DEG C are dried under reduced pressure, and crushed 60 mesh sieve；
Step d, gynostemma pentaphylla is sterilized with 60Coradiation, irradiation dose 4kGy crushed 60 mesh sieve；
Step e, step c products therefroms with step d products therefroms are mixed, adds in 85% mass concentration, mix powder
The ethyl alcohol softwood of quality 30% crosses 20 mesh sieve series grains, 55 DEG C dry), tea bag, every bag of 6g is made in 20 mesh sieve whole grain.
Application method：
Tea bag is placed in 80 DEG C or more hot water after impregnating 15 minutes and drunk, can brewed repeatedly 3~7 times.
Embodiment 5
An embodiment of the present invention provides a kind of auxiliary blood-fat reducing compositions, include the raw material of following parts by weight proportioning：Pueraria lobota
6 parts of root, 4 parts of Radix Angelicae Sinensis, 3 parts of Rhizoma Chuanxiong, 1.5 parts of Radix Notoginseng, 1.5 parts of Radix Glycyrrhizae, 7 parts of gynostemma pentaphylla.
Preparation method：
Step a, each raw material components are weighed by raw material proportioning, pueraria lobata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Radix Glycyrrhizae is added into 12 times of quality
Water impregnates 2.5 hours, decocts 2.5 hours；
Step b, it filters, the water of 12 times of quality is added into filtrate, decoct 2.5 hours；Repeat this step 1 time；
Step c, merging filtrate, 65 DEG C of reduced pressures, 65 DEG C are dried under reduced pressure, and crushed 60 mesh sieve；
Step d, gynostemma pentaphylla is sterilized with 60Coradiation, irradiation dose 4.5kGy crushed 60 mesh sieve；
Step e, step c products therefroms with step d products therefroms are mixed, adds in 85% mass concentration, mix powder
The ethyl alcohol softwood of quality 30% crosses 20 mesh sieve series grains, 55 DEG C dry), tea bag, every bag of 6g is made in 20 mesh sieve whole grain.
Application method：
Tea bag is placed in 80 DEG C or more hot water after impregnating 15 minutes and drunk, can brewed repeatedly 3~7 times.
Pharmacodynamics test
Experimental animal：SPF grades of SD rats totally 50, weight (200 ± 20) g, male.Per 5, cage, separately raise.It adapts to
Property raising 5 days, feed normal diet and drinking water.
Test material：The gained auxiliary blood-fat reducing composition of embodiment 3 is made after tea bag with 80 DEG C or more hot-water soaks 5
It is secondary, it impregnates 15 minutes every time, solid is made after being concentrated under reduced pressure, being dried under reduced pressure in leachate, face the used time with according to dosage using respectively
Drinking water is dissolved into solution, is divided into and carries out gavage to experimental animal three times, and gavage capacity is 10mL/kg.
High lipid food formula：50% basal feed, 20% sucrose, 15% lard, 5% cholesterol, 10% albumen powder are made
It is blocky.
Animal packet：SD rats after adaptability is raised 5 days are randomly divided into 5 groups：Blank control group 10, hyperlipidemia model
Control group 10, low dosage test group 10, middle dosage test group 10, high dose test group 10.Auxiliary in the present invention
The dosage of blood-fat reducing composition is every bag of 6g, is calculated by adult human body weight 70kg, low dosage test group, middle dosage test group, height
The dosage of dosetest group is respectively that 0.86g/kg, 1.71g/kg, 2.57g/kg (are respectively equivalent to human body recommended dose
10 times, 20 times, 30 times).
Test method：Blank control group feeds normal diet, hyperlipidemia model control group and low dosage test group, middle dosage
Test group, high dose test group feed high lipid food.After 4 weeks, endocanthion takes blood, measures each group Rat Cholesterol TC, glycerine three
Ester TG, high-density lipoprotein HDL-C and low-density lipoprotein LDL-C are horizontal.It the results are shown in Table 1.
Table 1 assists influence of the blood-fat reducing composition to rat fat
Compared with blank control group, the horizontal significantly raising (P of TC, TG, LDL-C of hyperlipidemia model control group<0.05), HDL-
The horizontal poles of C significantly reduce (P<0.01).Compared with hyperlipidemia model control group, TC, LDL-C of basic, normal, high dosetest group are horizontal
Significantly reduce (P<0.05), the horizontal significantly raising (P of HDL-C<0.05), the horizontal poles of TG significantly reduce (P<0.01).
By more than clinical testing data as it can be seen that the auxiliary blood-fat reducing composition that is provided of the embodiment of the present invention 3 is for dropping
During blood fat, have clear improvement for blood fat indices.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
Any modification, equivalent replacement or improvement made within refreshing and principle etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of auxiliary blood-fat reducing composition, it is characterised in that：Include the raw material of following parts by weight proportioning：2~6 parts of pueraria lobata,
2~4 parts of Radix Angelicae Sinensis, 1~3 part of Rhizoma Chuanxiong, 0.5~1.5 part of Radix Notoginseng, 0.5~1.5 part of Radix Glycyrrhizae, 3~7 parts of gynostemma pentaphylla.
2. auxiliary blood-fat reducing composition according to claim 1, it is characterised in that：Include the original of following parts by weight proportioning
Material：3~5 parts of pueraria lobata, 1.5~2.5 parts of Rhizoma Chuanxiong, 0.8~1.2 part of Radix Notoginseng, 0.8~1.2 part of Radix Glycyrrhizae, twists 2.5~3.5 parts of Radix Angelicae Sinensis
Stock is 4~6 parts blue.
3. auxiliary blood-fat reducing composition according to claim 2, it is characterised in that：Include the original of following parts by weight proportioning
Material：4 parts of pueraria lobata, 3 parts of Radix Angelicae Sinensis, 2 parts of Rhizoma Chuanxiong, 1 part of Radix Notoginseng, 1 part of Radix Glycyrrhizae, 5 parts of gynostemma pentaphylla.
4. a kind of preparation method of claim 1-3 any one of them auxiliary blood-fat reducing composition, which is characterized in that described auxiliary
Help blood-fat reducing composition by the raw material it is soaking, decoct, concentrate, dry, crush, mix.
5. the preparation method of auxiliary blood-fat reducing composition according to claim 4, which is characterized in that include the following steps：
Step a, each raw material components are weighed by raw material proportioning, pueraria lobata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Radix Glycyrrhizae is soaked, decocted；
Step b, it filters, water is added into filtrate, decoct；Repeat this step 1~2 time；
Step c, merging filtrate, concentration, dry, crushing；
Step d, gynostemma pentaphylla is sterilized, crushed；
Step e, step c products therefroms with step d products therefroms are mixed, oral products is made.
6. the preparation method of auxiliary blood-fat reducing composition according to claim 5, which is characterized in that institute in the step a
It states plus the quality of water is 8~12 times of quality of material；And/or
The quality for adding water described in the step b is 8~12 times of quality of material；And/or
It is impregnated described in the step a to impregnate 1.5~2.5 hours；And/or
It is decocted described in the step a to decoct 1.5~2.5 hours；And/or
It is decocted described in the step b to decoct 1.5~2.5 hours.
7. the preparation method of auxiliary blood-fat reducing composition according to claim 5, which is characterized in that described in the step c
It sterilizes as Co 60,4kGy irradiation sterilizations.
8. the preparation method of auxiliary blood-fat reducing composition according to claim 5, which is characterized in that institute in the step c
Concentration is stated to be concentrated under reduced pressure, temperature is 55~75 DEG C；And/or
Dry to be dried under reduced pressure described in the step c, temperature is 55~65 DEG C；And/or
It is crushed described in the step c to be crushed to 60~100 mesh sieve；
It is crushed described in the step d to be crushed to 60~100 mesh sieve.
9. a kind of tea bag, which is characterized in that the content of the tea bag is dropped by any one of claims 1 to 3 auxiliary
Blood fat composition is made with excipient.
10. application of any one of the claim 1-3 auxiliary blood-fat reducing compositions as auxiliary blood fat reducing health products.
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| CN109007788A (en) * | 2018-08-23 | 2018-12-18 | 辽宁兴海制药有限公司 | A kind of blood-fat reducing composition and its preparation method and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895300A (en) * | 2012-05-23 | 2013-01-30 | 刘宗奎 | Traditional Chinese medicine compound capsule for reducing blood sugar, blood fat and blood pressure and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895300A (en) * | 2012-05-23 | 2013-01-30 | 刘宗奎 | Traditional Chinese medicine compound capsule for reducing blood sugar, blood fat and blood pressure and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109007788A (en) * | 2018-08-23 | 2018-12-18 | 辽宁兴海制药有限公司 | A kind of blood-fat reducing composition and its preparation method and application |
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Effective date of registration: 20200527 Address after: No.012, Jiazhuang administrative village, Jiazhuang Town, Mudan District, Heze City, Shandong Province Applicant after: Lan Xiang Address before: 101300, No. two, 1 road, Shunyi Park, Zhongguancun science and Technology Park, Beijing, Shunyi District Applicant before: ZHONGTAI YIJIA HEALTH TECHNOLOGY (BEIJING) Co.,Ltd. |