CN102599501B - Healthcare Hongyang capsule or tablet product for lowering lipid and protecting liver - Google Patents
Healthcare Hongyang capsule or tablet product for lowering lipid and protecting liver Download PDFInfo
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- CN102599501B CN102599501B CN2012100669098A CN201210066909A CN102599501B CN 102599501 B CN102599501 B CN 102599501B CN 2012100669098 A CN2012100669098 A CN 2012100669098A CN 201210066909 A CN201210066909 A CN 201210066909A CN 102599501 B CN102599501 B CN 102599501B
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Abstract
A healthcare Hongyang capsule or tablet product for lowering lipid and protecting liver belongs to the field of healthcare food or medicine and preparation method thereof. The healthcare Hongyang capsule or tablet product is mainly technically characterized in that a method for preparing the healthcare Hongyang capsule or tablet product includes steps of taking pseudo-ginseng, American ginseng and red konjic rice powder by weight and are crushed into fine powder to be reserved at first; then taking broadleaf holly leaves to be crushed into threadlet and adding water into the threadlet to be stewed twice; adding water with the weight larger than that of raw materials by 5 times to 10 times for the first time, stewing for 1 hour to 5 hours, and extracting out stewing liquid; adding water with the weight larger than that of the raw materials by 5 times to 10 times for the second time, and stewing for 1 hour to 5 hours; mixing the stewing liquid, filtering the stewing liquid and decompressing the stewing liquid into liquid with relative weight density ranging from 1.15 to 1.25; mixing the liquid into the fine powder to form paste; decompressing and drying the paste; crushing the paste into powder with mesh of 60; preparing capsules or tablets; and packaging the capsules or tablets after sterilizing. The healthcare food or medicine can lower the blood lipid, relieves steatotic hepatocyte, prevents steatotic hepatocyte, has a healthcare function of preventing ethanol-induced liver damage, and accordingly has a remarkable effect for preventing and curing diseases of hyperlipidemia, fatty liver, ethanol-induced liver damage and the like.
Description
Technical field
The invention belongs to health food or Chinese medicine manufacturing technology field, particularly Chinese medicinal food and manufacture method thereof.
Technical background
Hyperlipemia refer to cholesterol in serum (TC), triglycerides (TG) and low-density lipoprotein (LDL) too high and (or) illness of the too low a kind of whole body fat metabolic disorder of serum high-density LP (HDL); Chemical damage is the hepar damnification that is caused by the chemistry Hepatoxic substance take alcohol as representative.
Along with improving constantly of China's living standards of the people, picked-up lipid food and the probability of drinking all increase, and cause the patient of hyperlipemia and chemical damage to increase rapidly, and health is caused very big infringement.Such as: hyperlipidemia is the major reason that causes the illness such as coronary heart disease, headstroke, myocardial infarction, hypertension, diabetes, artery sclerosis, fatty liver, cholelithiasis, obesity, pancreatitis, chronic nephritis, and the chance that the high fat of blood person suffers from a heart complaint is about four times of normal person.
Have on market some treatment hyperlipemias and chemical damages product, but these products mostly are the simple combination of Chinese medicine material or only process through elementary, effect is relatively limited to; And tend to toxic and side effect with hepar damnification with the blood fat-reducing product that chemical raw material is made.On the other hand, with DDB, Tiopronins etc. represent the treatment chemical damage preparation that raw material is made, because composition is too single, be difficult to treat the many-side damage that chemical damage brings, and the combination of formula Raw is not comprehensive, effect, adverse reaction rate irritated, digestive system is higher, sometimes even can increase the weight of chemical damage.For example, the Cai Hao of Beijing Ditan Hospital waits in east and reports, has 5 routine patients to cause that on the contrary hepatic lesion increases the weight of in taking DDB treatment hepatic lesion process.Therefore, research and develop out clinical effectiveness with natural constituent certain under instruction of Chinese Medicine theory, safety non-toxic can auxiliary antilipemic, again can to chemical damage have protective action health food be a problem highly significant.
Motherland's medical science thinks, the generation of hyperlipemia and chemical damage is all relevant with factors such as " temper virtual loss, essential resistance of turbid phlegm, stagnation of QI and blood ", under tcm theory instructs, hyperlipemia and chemical damage treated good curative effect.Therefore we in line with the principle of traditional Chinese medicine " strengthening the spleen and replenishing qi reduces phlegm that it is turbid to disappear, blood circulation promoting regulates qi ", select the natural material of high effect nontoxic, have developed the red foreign capsule of health food or the tablet of the lowering fat and protecting liver with effects such as auxiliary antilipemics.Have that clinical formulation is superior, technique is reasonable, effect is certain, taking convenience, safety non-toxic, can auxiliary antilipemic, simultaneously again can liver protecting, the characteristics such as treatment chemical damage have positive role aspect the human health level improving.The capsule preparations of this product has been obtained the strong word G20110657 health food certificate of approval of state's food that State Food and Drug Administration has auxiliary antilipemic, chemical damage had the assistant protection function effect in November, 2011.Wait at present official listing.
Summary of the invention
The purpose of this invention is to provide a kind of effect really, taking convenience, safety non-toxic, can auxiliary antilipemic, have again liver protecting simultaneously, the product of the characteristics such as treatment chemical damage.
The red foreign capsule of a kind of health food of lowering fat and protecting liver or tablet are made by the raw material of following weight parts: pseudo-ginseng 5-50 part, American Ginseng 5-50 part, red colouring agent for food, also used as a Chinese medicine 5-50 part, Ilex Latifolia Thunb 5-50 part.
The red foreign capsule of the health food of lowering fat and protecting liver or tablet prepare as follows: first get the pseudo-ginseng of above-mentioned weight, American Ginseng and red colouring agent for food, also used as a Chinese medicine are ground into 100-120 order fine powder standby.The lectuce tea powder of getting again above-mentioned weight is broken into the filament of 8-10mm, boiling 2 times.Add for the first time Ilex Latifolia Thunb weight 5-10 water doubly, decocted 1-5 hour, take out decocting liquid; Add again for the second time Ilex Latifolia Thunb weight 5-10 water doubly, decocted 1-5 hour.Collecting decoction filter, then reduced pressure concentration becomes relative weight density 1.15-1.25.Mix cream with above fine powder, 70-80 ℃ of drying under reduced pressure is ground into 60 order powder, makes capsule or tablet, packing after sterilization.
Pharmacology analysis:
Pseudo-ginseng (Panax no to ginseng (Burk) F.H.chen): being the root of Araliaceae herbaceos perennial pseudo-ginseng, is the distinctive medicinal material kind of China, since the Compendium of Material Medica record, and the history of existing more than 500 year.Modern study shows, pseudo-ginseng contains notoginsenoside, flavonoid glycoside, Quercetin, quercitin, β one sitosterol etc., and wherein notoginsenoside is main active.The research discovery, pseudo-ginseng has good auxiliary therapeutic action to auxiliary antilipemic and chemical damage.
The clinical research confirmation of Huang Zehua, Radix Notoginseng total glucosides tablet have the effect of obvious reduction triglycerides and cholesterol.The result of study that Shen Huiyun etc. carry out shows, high dose group obviously alleviates (P＜0.05) than the control group necrosis of liver cells.Film 5-N ', ATPase, SDH, NADPH activity be all than control group high (P＜0.05), and the prompting pseudo-ginseng has auxiliary protection function to liver tissues of rats damage due to carbon tetrachloride.Studies confirm that of Lee's Zhe etc., pseudo-ginseng can be improved the microcirculation of liver, significantly increases vascular flow, reduces the GPT in perfusate, alleviates the pathology damage of liver.
The function that has good and certain auxiliary antilipemic and auxiliary curing chemical damage due to pseudo-ginseng is one of raw material of this preparation so we select it.
American Ginseng (Panax quinquefolium L.): be the root of the perennial persistent root herbs of Araliaceae Panax, cool in nature, bitter but sweet flavor is Qi-tonifying drug important in Chinese medicine.
Qi-tonifying drug plays the subsidy of human righteousness's weakness, supporting role, and it has the effect of the low gene function group of activation, rise vigor, can promote vital movement.According to the literature, American ginseng saponin can reduce the abnormal lipoproteins-C concentration of high fat rat, alleviates hyperlipemia to the damage of blood vessel.Separately have result of study to show, American ginseng saponin has obvious growth promoting function to normal liver cell, and especially the American Ginseng growth-promoting effect is more obvious for the Hypoxic liver cell.
On the other hand, consider chemical damage from the angle of traditional Chinese medicine, the liver belonging to wood, spleen pertaining to the earth, Wood restricts earth on the five-element, therefore when hepatopathy occurring, the function of the digestion such as taste also easily sustains damage.During this time, the function of reinforcement taste is very necessary for human body.Just emphasize " seeing hepatopathy, first real spleen " in classic doctor's collection " Synopsis Golden Chamber ".Therefore, we enter prescription with the key medicine American Ginseng group of air making-up and spleen enlivening, and auxiliary pseudo-ginseng reaches the purpose of auxiliary curing high fat of blood and chemical damage jointly.And American Ginseng is cool in nature, mends and not dry, and clothes are difficult for getting angry for a long time, and this develops safely and effectively for us that health food is very useful.
Ilex Latifolia Thunb (Ilex kudingcha C.J.Tseng): the leaf that is mainly holly plant Cortex Ilicis Rotundae or Chinese holly.Ilex Latifolia Thunb includes polyphenol, triterpene, flavone compound, ursolic acid, β-amyrin, Lupeol, and the trace elements such as the selenium wanted of multiple physiologically active natural materials and needed by human body, zinc, to treatment liver disease, reducing blood lipid etc. effectively.
The experimental study of the Ilex Latifolia Thunb effect for reducing fat that Xiang Hualin etc. carry out shows, Ilex Latifolia Thunb can reduce cholesterol, reduces triglycerides, reduces LDL, and the ratio of the HDL/LDL that can raise.
Yang Biao etc. make its tissue that lipid peroxidation occurs under the inducing of derivant and cause the histocyte damage hepatic tissue is external; Then, with multiple Folum Ilicis extract, its antioxidation is studied.Experimental result shows, Folum Ilicis extract has inhibitory action to the external lipid peroxidation of rats'liver, and be dose-effect relationship in the finite concentration scope when various experimental concentration.
In recent years, protecting the liver one of research on mechanism focus is its anti-hepatic fibrosis, and lipid peroxidation plays an important role in the liver fibrosis process.Unming Medical College's Chen Guozhen etc. is studied Ilex Latifolia Thunb glycocide lipoid peroxidization resistant, result shows, ilexlutifolia thumb total glycosides and three kinds of time delays that glycocide can significantly reduce foundation of microsomal Lipid Peroxidation product MDA level, prolongation LDL oxidative modification, can also significantly reduce mice serum and liver MDA elevated levels, think that Ilex Latifolia Thunb has lipoid peroxidization resistant.
Red colouring agent for food, also used as a Chinese medicine (Red yeast rice): being called again red song, red bent, is the Chinese medicine of the traditional medicine-food two-purpose with the effect such as promoting blood circulation and removing blood stasis, reinforcing spleen to promote digestion of China.Its main component is HMG CoA (HMG2CoA) reductase inhibitor and multiple essential amino acid, unrighted acid and Flavonoid substances, has clear and definite lipopenicillinase and antiatherogenic effect.Result of study shows, dyslipidemia is had good curative effect.
The polyunsaturated fatty acid that is rich in red colouring agent for food, also used as a Chinese medicine can also stimulate liver L DL acceptor, and the increase acceptor quantity reaches the affinity with LDL, increases the mobility of acceptor, and the TC level is descended.
The GABA that contains in red colouring agent for food, also used as a Chinese medicine (GABA) can generate glutamic acid with the KG reaction, suppress the decarboxylic reaction of glutamic acid, ammonia concentration is effectively reduced, can also impel more glutamic acid to be combined generation urea with ammonia and excrete, releasing ammonia poison is promoted liver function.Also find when research red colouring agent for food, also used as a Chinese medicine effect for reducing blood fat, GABA has relieving alcohol to the effects such as toxicity of neuroblast.Alcohol has neurotoxicity, and form and the biochemical property of neuroblast had great impact.And GABA can relieving alcohol to the toxicity of neuroblast, be held in the phenotype of nerve cell, have neurotrophic effect.This chemical damage phenomenon that comparatively serious excessive consumption of alcohol causes for China's ubiquity has positive effect.
Studies show that in sum, pseudo-ginseng, American Ginseng, Ilex Latifolia Thunb, red colouring agent for food, also used as a Chinese medicine all have the effect of auxiliary antilipemic and auxiliary protection chemical damage aspect preferably.They can coordinate to promote aspect auxiliary antilipemic and protection chemical damage mutually, and toxic and side effect is very little, can make health food safely and effectively.
From the compatibility thought of science of TCM formulas, the compound material preparation that the effect aspect is more consistent often can be brought into play synergy.In this side, pseudo-ginseng and American Ginseng compatibility have good blood circulation promoting competent silt, and beneficial this effect of gas-solid is main medicine; The existing merit of invigorating blood circulation of red colouring agent for food, also used as a Chinese medicine has again the effect of invigorating the spleen, assists pseudo-ginseng and American Ginseng with it, and play the same tune on different musical instruments wonderful can be arranged; Help with Ilex Latifolia Thunb again, help loose wind-heat, dampness elimination is turbid, eliminating pathogen to support vital qi.The same use of all medicines can be played blood circulation promoting competent silt, beneficial gas-solid basis, the turbid merit of reducing phlegm altogether.And, between each raw material without incompatibility, consumption safety, exact efficacy, has chemical damage danger person edible for a long time at the person that is suitable for the Hyperlipidemia.So we with its prescription, make capsule or tablet.
The red foreign capsule of the refined elegant board of fragrant grass is through Beijing Disease Prevention and Control Centre, and the authoritative institution such as China TCM Academy of Sciences Xiyuan Hospital, carried out zoopery and human trial, and result confirms for reducing blood lipid and to chemical damage, remarkable result is arranged all.The capsule preparations of this product in November, 2011, has been obtained the strong word G20110657 health food certificate of approval of state's food that State Food and Drug Administration has auxiliary antilipemic, chemical damage had the assistant protection function effect.
This each stock yard of filling a prescription is without incompatibility, and health care is definite, can reach the health-care efficacy that has pair chemical damage that auxiliary protection function is arranged, and the raw material consumption is less, takes safety, is suitable for long-term edible.
The specific embodiment
The red foreign capsule of the health food of lowering fat and protecting liver or tablet are made by the raw material of following weight parts: pseudo-ginseng 5-50 part, American Ginseng 5-50 part, red colouring agent for food, also used as a Chinese medicine 5-50 part, Ilex Latifolia Thunb 5-50 part.
The parts by weight of raw materials of optimum ratio is: 30 parts of pseudo-ginseng, 30 parts of American Ginsengs, 30 parts, red colouring agent for food, also used as a Chinese medicine, 30 parts of Ilex Latifolia Thunbs.
The manufacture method of the red foreign capsule of the health food of lowering fat and protecting liver or tablet: first get the pseudo-ginseng of above-mentioned weight, American Ginseng and red colouring agent for food, also used as a Chinese medicine are ground into 100-120 order fine powder standby.The Ilex Latifolia Thunb part of getting again above-mentioned weight is ground into the filament of 8-10mm, boiling 2 times.Add for the first time Ilex Latifolia Thunb weight 5-10 water doubly, decocted 1-5 hour, take out decocting liquid; Add again for the second time Ilex Latifolia Thunb weight 5-10 water doubly, decocted 1-5 hour.Collecting decoction filter, then reduced pressure concentration becomes relative weight density 1.15-1.25.Mix cream with above fine powder, 70-80 ℃ of drying under reduced pressure is ground into 60 order powder, makes capsule or tablet, packing after sterilization.
The red foreign capsule of the health food of lowering fat and protecting liver of the present invention or tablet, everyone 2g every day of amount has obvious food therapy effect to high fat of blood and chemical damage.
Beijing Disease Prevention and Control Centre, and China TCM Academy of Sciences Xiyuan Hospital uses this preparation, to 100 satisfactory high fat of blood experimenters, is divided at random test-meal group and blank group, carried out the experiment of auxiliary antilipemic human experiment, its summary of results is as follows:
Table 1: before and after test-meal, cholesterol changes unit: (mmol/L)
| Number of cases | Before test-meal | After test-meal | Difference | Efficient % | |
| The test-meal group | 50 | 6.37±1.06 | 5.71±1.18 | 0.66±0.96** | 48 (24 examples) |
| Control group | 50 | 6.05±1.12 | 6.28±1.36 | -0.23±0.83# | 20 (10 examples) |
Self is relatively: #P＜0.05 relatively between * * P＜0.01 group
Table 2: before and after test-meal, triglycerides changes unit: (mmol/L)
| Number of cases | Before test-meal | After test-meal | Difference | Efficient % | |
| The test-meal group | 50 | 3.79±2.77 | 2.53±1.56 | 1.26±1.63** | 78 (39 examples) |
| Control group | 50 | 3.19±1.98 | 3.11±2.64 | 0.07±1.27# | 34 (17 examples) |
Self is relatively: #P＜0.05 relatively between * * P＜0.01 group
Main Conclusions is: have the auxiliary antilipemic effect.High fat of blood experimenter's sense of fatigue, the symptom such as uncomfortable in chest, dizzy, irritated are improved effect.Before and after test-meal, hemoglobin, red blood cell, leucocyte, total serum protein, albumin, glutamic-pyruvic transaminase, glutamic-oxalacetic transaminease, creatinine, urea, blood sugar, routine urinalysis, just conventionally etc. detect index substantially in normal range (NR), illustrate that this product has no adverse effects to the experimenter is healthy.Before and after examination trencherman test-meal, heart rate, blood pressure are in normal range (NR).Have no irritated and other bad reaction.
Beijing Disease Prevention and Control Centre uses this preparation to carry out the auxiliary antilipemic zoopery to 40 cleaning level Wister kind male rats, and its summary of results is as follows:
The impact of table 3. on the rat fat index
Self compares: * P＜0.05
Main Conclusions is: be determined with the effect of auxiliary antilipemic according to the criterion of auxiliary antilipemic zoopery detection method in Ministry of Public Health's " health food check and assessment technique standard " (version in 2003).
Beijing Disease Prevention and Control Centre uses this preparation to carry out that to 50 Male Kunming strain mice chemical damage is had auxiliary protection defencive function check (alcoholic hepatic injury model) zoopery, and its summary of results is as follows:
Table 4: on the impact of mda content in mouse liver
Compare with positive controls: * * P＜0.01
Main Conclusions is: tested material can reduce mda content in hepatic tissue.
Table 5: on the impact of reduced glutathione content in mouse liver
Compare with positive controls: * P＜0.05 * * P＜0.01
Main Conclusions is: tested material can effectively stop the exhaustion of reduced glutathione.
Table 6: on the impact of mouse liver triglycerides
With positive controls
Relatively: * * P＜0.01
Main Conclusions is: tested material can reduce the content of triglycerides in liver.
Table 7: the impact of liver fat being dripped distribution
Compare with positive controls: * P＜0.05 * * P＜0.01
The hepatic cell fattydegeneration standards of grading:
-liver cell lactones drips and is dispersed in, rareness.0 minute
+ contain the liver cell that fat drips to be no more than 1/4.1 minute
++ contain the liver cell that fat drips and be no more than 1/2.2 minutes
The liver cell that +++contain, fat dripped is no more than 3/4.3 minutes
++ ++ hepatic tissue is almost dripped replacement by fat.4 minutes
Main Conclusions is: this tested material can effectively stop ethanol to cause liver GSH (reduced glutathione) to exhaust and MDA (MDA) raises, and alleviates hepatic cell fattydegeneration, has prevention Ethanol hepatic injury function.
Claims (3)
1. the health-caring capsule of a lowering fat and protecting liver or tablet, belong to health food or medicine, it is characterized in that: the raw material by following weight parts is prepared from: pseudo-ginseng 5-50 part, American Ginseng 5-50 part, red colouring agent for food, also used as a Chinese medicine 5-50 part, Ilex Latifolia Thunb 5-50 part.
2. the health-caring capsule of lowering fat and protecting liver claimed in claim 1 or tablet, it is characterized in that: the raw material by following preferred weight part is prepared from: 30 parts of pseudo-ginseng, 30 parts of American Ginsengs, 30 parts, red colouring agent for food, also used as a Chinese medicine, 30 parts of Ilex Latifolia Thunbs.
3. the preparation method of the red foreign capsule of the health food of a lowering fat and protecting liver or tablet, is characterized in that, prepare through following method: first get the pseudo-ginseng of above-mentioned weight, American Ginseng and red colouring agent for food, also used as a Chinese medicine are ground into 100-120 order fine powder standby; The lectuce tea powder of getting again above-mentioned weight is broken into the filament of 8-10mm, and boiling 2 times adds Ilex Latifolia Thunb weight 5-10 water doubly for the first time, decocts 1-5 hour, takes out decocting liquid; Add for the second time Ilex Latifolia Thunb weight 5-10 water doubly again, decocted 1-5 hour, collecting decoction filters, reduced pressure concentration becomes relative weight density 1.15-1.25 again, mixes cream with above fine powder, 70-80 ℃ of drying under reduced pressure, be ground into 60 order powder, make capsule or tablet, packing after sterilization.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012100669098A CN102599501B (en) | 2012-03-15 | 2012-03-15 | Healthcare Hongyang capsule or tablet product for lowering lipid and protecting liver |
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| CN2012100669098A CN102599501B (en) | 2012-03-15 | 2012-03-15 | Healthcare Hongyang capsule or tablet product for lowering lipid and protecting liver |
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| CN102599501B true CN102599501B (en) | 2013-11-06 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103393114B (en) * | 2013-08-06 | 2016-01-13 | 西藏月王生物技术有限公司 | With the preparation method of highland barley monascus for the preparation of main hypolipemic and heart tonifying develop immunitypty |
| CN104127763A (en) * | 2014-06-27 | 2014-11-05 | 桂林浩新科技服务有限公司 | Traditional Chinese medicine preparation for treatment of hepatopathy |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1383871A (en) * | 2002-05-27 | 2002-12-11 | 云大科技股份有限公司 | Notoginseng and fermented red rice composition for preventing and treating cardiac and cerebral vascular diseases |
| CN1488367A (en) * | 2002-10-08 | 2004-04-14 | 朱上翔 | Taiwan lectuce herb-American ginseng capsule |
| CN1970008A (en) * | 2006-11-29 | 2007-05-30 | 李敬谋 | Health tea capable of lowering blood pressure and decreasing blood fat and preparation process thereof |
| CN101766666A (en) * | 2009-01-07 | 2010-07-07 | 谢永杰 | Chinese medicament for treating cardiovascular and cerebrovascular diseases |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1383871A (en) * | 2002-05-27 | 2002-12-11 | 云大科技股份有限公司 | Notoginseng and fermented red rice composition for preventing and treating cardiac and cerebral vascular diseases |
| CN1488367A (en) * | 2002-10-08 | 2004-04-14 | 朱上翔 | Taiwan lectuce herb-American ginseng capsule |
| CN1970008A (en) * | 2006-11-29 | 2007-05-30 | 李敬谋 | Health tea capable of lowering blood pressure and decreasing blood fat and preparation process thereof |
| CN101766666A (en) * | 2009-01-07 | 2010-07-07 | 谢永杰 | Chinese medicament for treating cardiovascular and cerebrovascular diseases |
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