CN104173585A - Adaptogen preparation containing rhodiola rosea and preparation method thereof - Google Patents
Adaptogen preparation containing rhodiola rosea and preparation method thereof Download PDFInfo
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- CN104173585A CN104173585A CN201410437729.5A CN201410437729A CN104173585A CN 104173585 A CN104173585 A CN 104173585A CN 201410437729 A CN201410437729 A CN 201410437729A CN 104173585 A CN104173585 A CN 104173585A
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Abstract
The invention discloses an adaptogen preparation containing rhodiola rosea and a preparation method thereof. Raw materials of the adaptogen preparation containing rhodiola rosea comprise rhodiola rosea or rhodiola rosea extract; besides, American ginseng, eleutherococcus senticosus, gynostemma pentaphyllum, Chinese wolfberry fruit, sea-buckthorn, schisandra chinensis and the like can be combined. The adaptogen preparation containing the rhodiola rosea has the effect of improving the hypoxia tolerance.
Description
Technical field
The present invention relates to Chinese medicine, health food, relate in particular to adaptogen preparation containing Radix Rhodiolae and preparation method thereof.
Background technology
Body can feel uncomfortable to some extent for abnormal environment under many circumstances, especially, under the anoxia conditions such as plateau, therefore needs a kind of adaptogen preparation that can improve anoxia endurance.
Summary of the invention
The object of this invention is to provide a kind of adaptogen preparation containing Radix Rhodiolae and preparation method thereof, to improving anoxia endurance.
Adaptogen preparation containing Radix Rhodiolae of the present invention, its raw material packet contains Radix Rhodiolae or Radix Rhodiolae extract.
Optionally, the adaptogen preparation containing Radix Rhodiolae of the present invention, its raw material comprises the each component of following weight portion:
1～6 part of Radix Rhodiolae,
1～6 part of Fructus Lycii,
1～6 part of Fructus Hippophae.
Optionally, the adaptogen preparation containing Radix Rhodiolae of the present invention, its raw material comprises the each component of following weight portion:
1～6 part of Radix Rhodiolae,
1～6 part of Radix Et Caulis Acanthopanacis Senticosi,
1～6 part of Herb Gynostemmae Pentaphylli,
1～6 part of Fructus Lycii,
1～6 part of Fructus Hippophae,
1～6 part of Fructus Schisandrae Chinensis.
Optionally, the described adaptogen preparation containing Radix Rhodiolae, its raw material comprises the each component of following weight portion:
0.15～0.9 part of Radix Rhodiolae extract,
0.1～0.6 part of Fructus Lycii extract,
0.1～0.6 part of Fructus Hippophae extract.
Optionally, the described adaptogen preparation containing Radix Rhodiolae, its raw material comprises the each component of following weight portion:
0.15～0.9 part of Radix Rhodiolae extract,
0.15～0.9 part of Radix Et Caulis Acanthopanacis Senticosi extract,
0.15～0.9 part of Herb Gynostemmae Pentaphylli extract,
0.1～0.6 part of Fructus Lycii extract,
0.1～0.6 part of Fructus Hippophae extract,
0.1～0.6 part of Fructus Schisandrae Chinensis extrat.
The preparation method of the adaptogen preparation containing Radix Rhodiolae of the present invention, the former material of the crude drug of take when prepared by raw material, comprises the following steps:
(a), by proportioning, take each component and carry out cleaning treatment;
(b), add drinking water and decoct extraction, extracting solution concentrates, and makes concentrated solution;
(c), concentrated solution adds adjuvant, soft material processed sieve granulation, be dried, granulate, make dry granule; Or extract concentrated solution and add adjuvant, through one-step-granulating method, make dry granule; Or concentrated solution drying and crushing sieves and make extract powder, then add adjuvant, soft material processed sieve granulation, dry, granulate, make dry granule.
(d), packing.
The preparation method of the adaptogen preparation containing Radix Rhodiolae of the present invention, take the extract of crude drug when prepared by raw material, comprises the following steps:
(a), by proportioning, take each component and sieve;
(b), each extract mix homogeneously is obtained to total mixture;
(c), in total mixture, add adjuvant, soft material processed sieve granulation, dry, granulate, make dry granule; Or add adjuvant in total mixture, through one-step-granulating method, make dry granule;
(d), packing.
A kind of adaptogen health food containing Radix Rhodiolae of the present invention has the effect that improves anoxia endurance.
The preparation method of described Radix Rhodiolae extract, Radix Et Caulis Acanthopanacis Senticosi extract, Herb Gynostemmae Pentaphylli extract, Fructus Lycii extract, Fructus Hippophae extract, Fructus Schisandrae Chinensis extrat is as follows:
1, Radix Rhodiolae extract preparation method: 8 times of amount alcohol reflux of 70% 2 times for Radix Rhodiolae, 2h for the first time, 1h, filters for the second time, obtains extracting solution.Extracting solution, at temperature 60-70 ℃, is concentrated into relative density 1.10-1.20 under vacuum 0.07-0.08MPa, obtain concentrated solution.Concentrated solution is sprayed at inlet temperature 170-180 ℃ leaving air temp 70-80 ℃ dry, obtain spray powder.Spray powder is crossed to 80 mesh sieves, obtain Radix Rhodiolae extract.
2, Radix Et Caulis Acanthopanacis Senticosi extract preparation method:
8 times of amount alcohol reflux of 70% 2 times for Radix Et Caulis Acanthopanacis Senticosi, 2h for the first time, 1h, filters for the second time, obtains extracting solution.Extracting solution, at temperature 60-70 ℃, is concentrated into relative density 1.10-1.20 under vacuum 0.07-0.08MPa, obtain concentrated solution.Concentrated solution is sprayed at inlet temperature 170-180 ℃ leaving air temp 70-80 ℃ dry, obtain spray powder.Spray powder is crossed to 80 mesh sieves, obtain Radix Et Caulis Acanthopanacis Senticosi extract.
3, Herb Gynostemmae Pentaphylli extract production technology explanation:
8 times of amount alcohol reflux of 70% 2 times for Herb Gynostemmae Pentaphylli, 2h for the first time, 1h, filters for the second time, obtains extracting solution.Extracting solution, at temperature 60-70 ℃, is concentrated into relative density 1.10-1.20 under vacuum 0.07-0.08MPa, obtain concentrated solution.Concentrated solution is sprayed at inlet temperature 170-180 ℃ leaving air temp 70-80 ℃ dry, obtain spray powder.Spray powder is crossed to 80 mesh sieves, obtain Herb Gynostemmae Pentaphylli extract.
4, the production technology of Fructus Lycii extract explanation:
Fructus Lycii is pulverized, and obtains coarse powder.Fructus Lycii coarse powder is measured purified water extraction 2 times with 10 times, and each 2h, filters, and merges, and obtains extracting solution.Extracting solution, at temperature 70-80 ℃, is concentrated into relative density 1.10-1.20 under vacuum 0.07-0.08MPa, obtain concentrated solution.Concentrated solution adds ethanol to determining alcohol 80%, and standing 24h filters, and obtains precipitate.After the precipitate obtaining is redissolved with distilled water, carry out spray dried dry, obtain spray powder.Spray powder is crossed to 80 mesh sieves, obtain Fructus Lycii extract.
5, the production technology of Fructus Hippophae extract (seabuckthorn fruit powder) explanation:
Selected sea-buchthorn fresh fruit is cleaned with clear water, after draining, packed into disintegrating machine and pulverize, obtain Fructus Hippophae sarcocarp.Sarcocarp after pulverizing is put into juice extractor and squeeze the juice, the marc of squeezing the juice for the first time adds 15% clear water, after stirring, squeezes the juice for the second time.Merge for the first time, fruit juice for the second time, cross 100 mesh filter screens, obtain juice of Fructus Hippophae.The juice of Fructus Hippophae obtaining, at 50-60 ℃, under the condition of 0.06-0.08MPa, is evaporated to relative density 1.10-1.20 (60 ℃ of surveys), obtains Fructus Hippophae concentrated juice.By Fructus Hippophae concentrated juice instantaneous ultrahigh-temperature sterilization 15s at the temperature of 135-145 ℃, obtain the Fructus Hippophae concentrated juice after sterilizing.Fructus Hippophae concentrated juice after sterilized is sprayed under the condition of inlet temperature 170-180 ℃, leaving air temp 70-80 ℃ dry, obtain spray powder.Juice of Fructus Hippophae spray powder is crossed to 80 mesh sieves, obtain seabuckthorn fruit powder.
6, Fructus Schisandrae Chinensis extrat production technology explanation:
8 times of amount alcohol reflux of 70% 2 times for Fructus Schisandrae Chinensis, 2h for the first time, 1h, filters for the second time, obtains extracting solution.Extracting solution, at temperature 60-70 ℃, is concentrated into relative density 1.10-1.20 under vacuum 0.07-0.08MPa, obtain concentrated solution.Concentrated solution is sprayed at inlet temperature 170-180 ℃ leaving air temp 70-80 ℃ dry, obtain spray powder.Spray powder is crossed to 80 mesh sieves, obtain Fructus Schisandrae Chinensis extrat.
The instructions of taking of the adaptogen preparation containing Radix Rhodiolae of the present invention is: takes after mixing it with water, and every day 1 time, a 1-4 gram.
The composition of the rhodiola rosea formulated product of enhancing immunity of the present invention is carried out to analytic explanation from pharmacology aspect below.
Radix Rhodiolae
Be called as " plateau Radix Ginseng ".
Pharmacopeia regulation this product is dry root and the rhizome of crassulaceae plants Radix Rhodiolae Rhodiolacrenulata (Hook.f.et Thoms.) H.Ohba.Sweet, bitter, flat.Return lung, heart channel.Benefiting QI for activating blood circulation, promotes blood circulation and relievings asthma.For blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia asthma.
That Radix Rhodiolae mainly grows in is high and cold, anoxia, blast, ultraviolet radiation is strong, day and night temperature is large, great majority are all grown in height above sea level 3500-5000 rice left and right, under high mountain flowstone or scrub forest.Severe living environment makes Radix Rhodiolae possess special adaptability material from heredity, has the effect of the former state of adaptation.Be described as " plateau Radix Ginseng ".Be listed in < < Sheng Nong's herbal classic > > top grade, " the main life of supporting is with Ying Tian, nontoxic, takes clothes of a specified duration more and does not hurt sb.'s feelings ".The effect that has " QI invigorating of making light of one's life by commiting suicide, always do not prolong life ".Ming Dynasty Li Shizhen (1518-1593 A.D.) < < Compendium of Materia Medica > > thinks that " Radix Rhodiolae, herbal classic is top grade, eliminating evil bad odor, benefit various symptoms and signs of deficiency " is " in known tonic, institute is rare ".Qing Dynasty's Radix Rhodiolae is used as tribute and offers or present to emperor, once follows on Emperor Kangxi and crosses battlefield, and the envelope of being admired is " Radix Rhodiolae ".Because Siberia people's tradition is used as strong nourishing agent by Radix Rhodiolae, thereby promoted that also it is defined as a kind of adaptogen to the scientist of the former Soviet Union the most at last to its research.Human trial all shows the effects such as Radix Rhodiolae tool resisting fatigue, anti-stress, anti-hypoxia, anticancer, antioxidation, low temperature resistant, radioprotective, enhancing immunity, sexual function improving.Radix Rhodiolae has started for preventing altitude sickness, slow down aging clinically, the adjuvant drug for the treatment of coronary heart diseases and angina pectoris, arrhythmia, antitumor and chemotherapy.
Radix Et Caulis Acanthopanacis Senticosi
Be called as " Radix Acanthopanacis Senticosi ".
Pharmacopeia regulation this product is dry root and rhizome or the stem of Araliaceae Radix Et Caulis Acanthopanacis Senticosi Acanthopanazsentico.sus (Rupr.et Maxim.) Harms.Pungent, micro-hardship, temperature.Return spleen, kidney, heart channel.Replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.For deficiency of both the splenic and pulmonary QI, body void is weak, inappetence, deficiency of both the lung and kidney, chronic cough dyspnea due to deficiency, the soreness of waist and knee joint of suffering from a deficiency of the kidney, deficiency of both the heart and spleen, insomnia and dreamful sleep.
It,, at folks of china hyoscine very early, is a kind of of Chinese medicine Cortex Acanthopancis.In " Compendium of Materia Medica " of Ming Dynasty's Li Shizhen (1518-1593 A.D.), just note has the word of praise of " Ning get Yi slender acanthopanax, need not the full car of gold and jade ", and state clearly take Cortex Acanthopancis can " enter diet, strong strength, forget things ", " clothes are made light of one's life by commiting suicide and are endured hardships for a long time ".The pharmacological action main manifestations of Radix Et Caulis Acanthopanacis Senticosi is: improve body nonspecific resistance, regulate the physiological function of each organ and make it recover normal, the efficiency of physical strength reinforcing and mental activity.Its effect is substantially identical with Radix Ginseng or higher than Radix Ginseng.
Herb Gynostemmae Pentaphylli
Be called as " southern Radix Ginseng ".
Hunan Province's Chinese crude drug standard (2009 editions) is recorded, and Herb Gynostemmae Pentaphylli is bitter, micro-sweet, cool.Return lung, spleen, kidney channel.Tonify deficiency, heat clearing away, removing toxic substances.Weak for body void, nephrasthenia emission, leukopenia, hyperlipemia, viral hepatitis, chronic gastroenteritis, chronic tracheitis.
Herb Gynostemmae Pentaphylli name starts from bright < < Herbal for Relief of Famines > >, and the Radix Rhodiolae of meaning among the people, has life lengthening effect.Modern pharmacological research confirms, Herb Gynostemmae Pentaphylli contains the gypenoside (GPS) that kind more than 80 and ginsenoside have similar structures.GPS has resisting fatigue, strengthening by means of tonics, promotes cell metabolism, fat-reducing, reduces the multiple physiologically actives similar to ginsenoside such as blood fat, atherosclerosis, defying age, enhancing immunity.
Fructus Schisandrae Chinensis
Pharmacopeia regulation this product is the dry mature fruit of magnoliaceae schisandra Schisandrachinensis (Turcz.) Baill..Practise and claim " Radix Schisandrae Bicoloris ".Sour, sweet, temperature.Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous sweating, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, palpitation and insomnia.
Fructus Schisandrae Chinensis is gained the name because it has acid, sweet, bitter, peppery, salty five kinds of tastes in the sense of taste." impairment caused by overstrain is won thin for main QI invigorating, cough with dyspnea, tonifying for the deficiency, reinforcing YIN-essence, beneficial man's essence in < < herbal classic > > record." to list in the earliest Sheng Nong's herbal classic top grade for Fructus Schisandrae Chinensis, herbal function is the power of strengthening by means of tonics.Fructus Schisandrae Chinensis contains multiple components, and mainly, containing lignanoid, polysaccharide, volatile oil, triterpene, organic acid, aminoacid and inorganic elements etc., Main Ingredients and Appearance is lignanoids.Modern pharmacological research shows that Fructus Schisandrae Chinensis has the central nervous excitation of increasing, and strengthens human body spirit, muscle power and cardiovascular system tension force and cardiac contractile force, reduces Patients with Viral Hepatitis serum glutamic pyruvic transminase (ALT) isoreactivity.Also have analgesia, stable, refrigeration function, can promote cardiomotility and breathing, corticocerebral excitement and process of inhibition are also had to impact.
Fructus Lycii
Pharmacopeia regulation this product is the dry mature fruit of plant of Solanaceae lycium barbarum Lyciumbarbarum L..Sweet, flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
< < Compendium of Materia Medica > > records: " Fructus Lycii, kidney-tonifying sperm-generating, nourishing the liver, improving eyesight, hard smart bone, fatigue taking away, easily color, bleaches, and improving eyesight is calmed the nerves, and makes us long-lived." just point out in the > > of < < Sheng Nong's herbal classic: take for a long time hard muscles and bones; < < Mingyi Bielu > > meaning Fructus Lycii is good at " nourishing the essence and strengthening QI "; < < Treatise on Dietetic Therapy > > also records Fructus Lycii " the beneficial people of energy; remove asthenia " modern medicine study and shows, Fructus Lycii has the effects such as antioxidation, defying age, immunomodulating, blood sugar lowering, blood fat reducing.
Fructus Hippophae
This strain Mongols, Tibetan's conventional crude drugs.Dry mature fruit for Elaeangnaceae plant Fructus Hippophae Hippophaethamnoides L..Sour, puckery, temperature.Return spleen, stomach, lung, heart channel.Strengthening the spleen to promote digestion, eliminating phlegm and stopping cough, promoting blood circulation to remove blood stasis.For insufficiency of the spleen lack of appetite, abdominal pain due to retention of food, cough with copious phlegm, obstruction of qi in the chest and cardialgia, blood stasis amenorrhea, falls and flutters congestive edema.
Fructus Hippophae flavone is the pure natural medical of the diseases such as treatment ischemic heart desease, angina pectoris, myocardial infarction, at aspects such as defying age, antiallergic, antiviral and enhancing immunity, has pharmacological effect widely.The Fructrs Hippophae seed oil extracting from hippophae rhamnoides seed has defying age, antiulcer, treatment burn, gynaecopathia, and the effect such as radioprotective, clinical in preventing and treating some cardiovascular diseases, digestive tract disease and hepatitis etc.The hepatic injury that the Oleum Hippophae extracting from sarcocarp brings out carbon tetrachloride and acetaminophen has obvious protective effect.External has obvious therapeutical effect to animal skin scald, burn, wound.
Compatibility
All class medicines that can improve body nonspecific resistance, are called " adaptogen ".Former Soviet Union's S .M.Kirov Military medical academy is when finding analeptic, find some plant amedica energy enhancing body to adverse environmental factors (comprise physics, chemistry with biology) opposing (adaptation) ability, thereby make vital movement maintain normal condition.Propose this type of medicine and have the effect of the former state of adaptation.By anoxia enduring, cold resistant, the relevant experiments such as high temperature resistant and resisting fatigue, confirm to have a batch of tonification class Chinese medicine and some non-tonification class Chinese medicine to have the effect of the former state of adaptation.As Radix Rhodiolae, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli, Fructus Lycii, Fructus Hippophae, Fructus Schisandrae Chinensis etc. and some compound preparations.Radix Rhodiolae, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli, Fructus Lycii, Fructus Hippophae, Fructus Schisandrae Chinensis compatibility, Radix Rhodiolae is called as " plateau Radix Ginseng ", Radix Et Caulis Acanthopanacis Senticosi is called as " southern Radix Ginseng " by " Radix Acanthopanacis Senticosi ", Herb Gynostemmae Pentaphylli, be to be respectively grown in the medicine that different regions and Radix Ginseng have similar pharmacologically active, there is the effect of the former state of adaptation.Fructus Lycii, Fructus Hippophae are the adaptation former state fruit class medicines that originates in northwest, common and Radix Rhodiolae compatibility; Fructus Schisandrae Chinensis is the adaptation former state fruit class medicine that mainly originates in northeast, common and Radix Et Caulis Acanthopanacis Senticosi compatibility.The medicine (Radix Rhodiolae, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli) of all similar Radix Ginsengs be take as main in full side, Yiyang gas increases energy, take all fruit class medicines (Fructus Lycii, Fructus Hippophae, Fructus Schisandrae Chinensis) as auxiliary, yin nourishing blood yin fluid astringing Tianjin, two class compatibility of drugss, benefiting QI and nourishing blood is invigorated blood circulation, and the opposing adaptive capacity of enhancing body to all kinds of pessimal stimulations, particularly improves anoxia endurance.The Radix Rhodiolae (benefiting QI for activating blood circulation) and the Fructus Lycii (nourishing blood), Fructus Hippophae (invigorating blood circulation) compatibility that originate in northwest that wherein originate in northwest plateau anaerobic environment, have the effect that improves anoxia endurance.
The specific embodiment
Embodiment 1
The adaptogen preparation containing Radix Rhodiolae in the present embodiment formula is by weight: 0.75 part of Radix Rhodiolae extract, 0.24 part of lactose, 0.01 part of stevioside.
The preparation method of the adaptogen preparation containing Radix Rhodiolae of the present embodiment comprises the following steps:
1. sieve
By each supplementary material sieving for standby.
2. mix
After sieving, supplementary material mix homogeneously, obtains mixed powder.
3. granulate
Mixed powder is granulated with dry granulating machine, cross 16 mesh sieve granulate, obtain granule.
4. inner packing
Inner packing adopts aluminum-plastic composite membrane, 1g/ bag.
5. outer package
Outer package adopts corrugated case to pack.
6. check
According to company standard, test.
7. finished product is put in storage
Product is through putting in storage after the assay was approved.
Embodiment 2
The adaptogen preparation containing Radix Rhodiolae in the present embodiment formula is by weight: 0.15～0.9 part of Radix Rhodiolae extract, 0.1～0.6 part of Fructus Lycii extract, 0.1～0.6 part of Fructus Hippophae extract (seabuckthorn fruit powder).
The preparation method of the preparation of the present embodiment comprises the following steps:
1 sieves
By each former auxiliary sieving for standby.
2 mix
By each supplementary material mix homogeneously, obtain total mixed powder.
3 granulate
Mixed material is granulated with dry granulating machine, cross 16 mesh sieve granulate, obtain granule.
4 inner packings
Inner packing adopts aluminum-plastic composite membrane (standard No. YBB00132002), every bag of 2g.
5 outer package
Adopt corrugated case to carry out outer package.
6 checks
According to company standard, test.
7 warehouse-ins
Product is through putting in storage after the assay was approved.
Get this compositions that the preparation per os gavage in embodiment 2 gives mice various dose (333.3mg/kgBW, 666.7mg/kgBW, 1000mg/kgBW) after 30 days, the results are shown in Table 21-table 22.
The impact of this preparation of table 21 on mice Hypoxia under normal pressure
As seen from Table 21, each dosage group mice Hypoxia under normal pressure of sample is all higher than negative control group, and difference has significance (P<0.05).
This preparation of table 22 is on the impact of anoxia time of chmice acute cerebral ischemia
As seen from Table 22, the Ischemia Injury in Brain anoxia time of each dosage group mice of sample is all higher than negative control group, and difference has significance (P<0.05).
From the experimental data of showing 21-table 22, can find out, the preparation in the present embodiment has the function of the anoxia endurance that improves body.
In the present embodiment, containing the adaptogen preparation of Radix Rhodiolae formula by weight, can be specially (but being not limited to following formula):
A: 0.15 part of Radix Rhodiolae extract, 0.6 part of Fructus Lycii extract, 0.1 part of Fructus Hippophae extract.
B: 0.5 part of Radix Rhodiolae extract, 0.3 part of Fructus Lycii extract, 0.3 part of Fructus Hippophae extract.
C: 0.9 part of Radix Rhodiolae extract, 0.1 part of Fructus Lycii extract, 0.1 part of Fructus Hippophae extract.
D: 0.9 part of Radix Rhodiolae extract, 0.6 part of Fructus Lycii extract, 0.6 part of Fructus Hippophae extract.
Embodiment 3
The adaptogen preparation containing Radix Rhodiolae in the present embodiment is filled a prescription by weight and is: 0.15～0.9 part of Radix Rhodiolae extract, 0.1～0.9 part of Radix Et Caulis Acanthopanacis Senticosi extract, 0.15～0.9 part of Herb Gynostemmae Pentaphylli extract, 0.1～0.6 part of Fructus Lycii extract, 0.1～0.6 part of Fructus Hippophae extract, 0.1～0.6 part of Fructus Schisandrae Chinensis extrat.
The preparation method of the adaptogen preparation containing Radix Rhodiolae of the present embodiment comprises the following steps:
1, sieve
By each supplementary material sieving for standby.
2, mix
Each supplementary material mix homogeneously is obtained to total mixture.
3, soft material processed
Stevioside is dissolved in volumetric concentration 95% ethanol, using this solution as wetting agent, is mixed to get soft material with total mixed powder.
4, granulate
Soft material is crossed to 14 mesh sieves, obtain wet granular.
5, dry
Wet granular is dry at 60-70 ℃, obtain dry granule.
6, granulate
Dried particles is crossed 12 mesh sieve granulate.
7, inner packing
Inner packing aluminum-plastic composite membrane, every bag of 2g.
8, outer package
Outer package adopts corrugated case.
9, check
The inspection item that require according to company standard are tested.
Get this compositions that the preparation per os gavage in embodiment 3 gives mice various dose (333.3mg/kgBW, 666.7mg/kgBW, 1000mg/kgBW) after 30 days, the results are shown in Table 51-table 52.
The impact of this preparation of table 31 on mice Hypoxia under normal pressure
From table 32, each dosage group mice Hypoxia under normal pressure of sample is all higher than negative control group, and difference has utmost point significance (P<0.01).
This preparation of table 32 is on the impact of anoxia time of chmice acute cerebral ischemia
From table 32, the Ischemia Injury in Brain anoxia time of each dosage group mice of sample is all higher than negative control group, and difference has significance (P<0.05).
From the experimental data of showing 31-table 32, can find out, the preparation in the present embodiment has the function of the anoxia endurance that improves body.
In the present embodiment, containing the adaptogen preparation of Radix Rhodiolae formula by weight, can be specially (but being not limited to following formula):
A: 0.3 part of Radix Rhodiolae extract, 0.3 part of Radix Et Caulis Acanthopanacis Senticosi extract, 0.3 part of Herb Gynostemmae Pentaphylli extract, 0.3 part of Fructus Lycii extract, 0.3 part of Fructus Hippophae extract, 0.3 part of Fructus Schisandrae Chinensis extrat.
B: 0.15 part of Radix Rhodiolae extract, 0.15 part of Radix Et Caulis Acanthopanacis Senticosi extract, 0.9 part of Herb Gynostemmae Pentaphylli extract, 0.1 part of Fructus Lycii extract, 0.6 part of Fructus Hippophae extract, 0.1 part of Fructus Schisandrae Chinensis extrat.
C: 0.9 part of Radix Rhodiolae extract, 0.3 part of Radix Et Caulis Acanthopanacis Senticosi extract, 0.3 part of Herb Gynostemmae Pentaphylli extract, 0.6 part of Fructus Lycii extract, 0.3 part of Fructus Hippophae extract, 0.3 part of Fructus Schisandrae Chinensis extrat.
D: 0.15 part of Radix Rhodiolae extract, 0.9 part of Radix Et Caulis Acanthopanacis Senticosi extract, 0.15 part of Herb Gynostemmae Pentaphylli extract, 0.1 part of Fructus Lycii extract, 0.1 part of Fructus Hippophae extract, 0.6 part of Fructus Schisandrae Chinensis extrat.
Embodiment 4
The adaptogen preparation containing Radix Rhodiolae in the present embodiment is filled a prescription by weight and is: 1～6 part of Radix Rhodiolae, 1～6 part of Fructus Lycii, 1～6 part of Fructus Hippophae.
The preparation method of the adaptogen preparation containing Radix Rhodiolae of the present embodiment comprises the following steps:
(a), by proportioning, take each component and carry out cleaning treatment;
(b), the drinking waters that add 10 times of amount medical materials decoct extraction, extract 2 times, 2h for the first time, 1h for the second time, extracting solution is evaporated to relative density 1.10-1.30, makes concentrated solution;
(c), concentrated solution adds the adjuvants such as dextrin, granulate, dry, cross 12 mesh sieve granulate, make dry granule;
(d), packing.
In the present embodiment, containing the adaptogen preparation of Radix Rhodiolae formula by weight, can be specially (but being not limited to following formula):
A: 1 part of Radix Rhodiolae, 1 part of Fructus Lycii, 2 parts of Fructus Hippophaes.
B: 6 parts of Radix Rhodiolaes, 3 parts of Fructus Lycii, 6 parts of Fructus Hippophaes.
C: 2 parts of Radix Rhodiolaes, 6 parts of Fructus Lycii, 1 part of Fructus Hippophae.
D: 3 parts of Radix Rhodiolaes, 3 parts of Fructus Lycii, 3 parts of Fructus Hippophaes.
Embodiment 5
The adaptogen preparation containing Radix Rhodiolae in the present embodiment formula is by weight: 1～6 part of Radix Rhodiolae, 1～6 part of Radix Et Caulis Acanthopanacis Senticosi, 1～6 part of Herb Gynostemmae Pentaphylli, 1～6 part of Fructus Lycii, 1～6 part of Fructus Hippophae, 1～6 part of Fructus Schisandrae Chinensis.
The preparation method of the adaptogen preparation containing Radix Rhodiolae of the present embodiment comprises the following steps:
(a), by proportioning, take each component and carry out cleaning treatment;
(b), the drinking waters that add 10 times of amount medical materials decoct extraction, extract 2 times, 2h for the first time, 1h for the second time, extracting solution is evaporated to relative density 1.10-1.30, makes concentrated solution;
(c), concentrated solution adds the adjuvants such as dextrin, granulate, dry, cross 12 mesh sieve granulate, make dry granule;
(d), packing
Preparation in the present embodiment formula by weight can be specially (but being not limited to following formula):
A: 6 parts of Radix Rhodiolaes, 2 parts of Radix Et Caulis Acanthopanacis Senticosis, 3 parts of Herb Gynostemmae Pentaphylli, 6 parts of Fructus Lycii, 5 parts of Fructus Hippophaes, 1 part of Fructus Schisandrae Chinensis.
B: 6 parts of Radix Rhodiolaes, 1 part of Radix Et Caulis Acanthopanacis Senticosi, 6 parts of Herb Gynostemmae Pentaphylli, 1 part of Fructus Lycii, 6 parts of Fructus Hippophaes, 1 part of Fructus Schisandrae Chinensis.
C: 1 part of Radix Rhodiolae, 6 parts of Radix Et Caulis Acanthopanacis Senticosis, 1 part of Herb Gynostemmae Pentaphylli, 3 parts of Fructus Lycii, 1 part of Fructus Hippophae, 6 parts of Fructus Schisandrae Chinensis.
D: 3 parts of Radix Rhodiolaes, 3 parts of Radix Et Caulis Acanthopanacis Senticosis, 3 parts of Herb Gynostemmae Pentaphylli, 3 parts of Fructus Lycii, 3 parts of Fructus Hippophaes, 3 parts of Fructus Schisandrae Chinensis.
Finally it should be noted that: above embodiment only, in order to technical scheme of the present invention to be described, is not intended to limit; Although the present invention is had been described in detail with reference to previous embodiment, those of ordinary skill in the art is to be understood that: its technical scheme that still can record aforementioned each embodiment is modified, or to wherein part technical characterictic be equal to replacement; And these modifications or replacement do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (7)
1. containing an adaptogen preparation for Radix Rhodiolae, it is characterized in that, its raw material packet contains Radix Rhodiolae or Radix Rhodiolae extract.
2. the adaptogen preparation containing Radix Rhodiolae according to claim 1, is characterized in that, its raw material comprises the each component of following weight portion:
1～6 part of Radix Rhodiolae,
1～6 part of Fructus Lycii,
1～6 part of Fructus Hippophae.
3. the adaptogen preparation containing Radix Rhodiolae according to claim 2, is characterized in that, its raw material comprises the each component of following weight portion:
1～6 part of Radix Rhodiolae,
1～6 part of Radix Et Caulis Acanthopanacis Senticosi,
1～6 part of Herb Gynostemmae Pentaphylli,
1～6 part of Fructus Lycii,
1～6 part of Fructus Hippophae,
1～6 part of Fructus Schisandrae Chinensis.
4. the adaptogen preparation containing Radix Rhodiolae according to claim 1, is characterized in that, its raw material comprises the each component of following weight portion:
0.15～0.9 part of Radix Rhodiolae extract,
0.1～0.6 part of Fructus Lycii extract,
0.1～0.6 part of Fructus Hippophae extract.
5. the adaptogen preparation containing Radix Rhodiolae according to claim 4, is characterized in that, its raw material comprises the each component of following weight portion:
0.15～0.9 part of Radix Rhodiolae extract,
0.15～0.9 part of Radix Et Caulis Acanthopanacis Senticosi extract,
0.15～0.9 part of Herb Gynostemmae Pentaphylli extract,
0.1～0.6 part of Fructus Lycii extract,
0.1～0.6 part of Fructus Hippophae extract,
0.1～0.6 part of Fructus Schisandrae Chinensis extrat.
6. contain as claimed in claim 2 or claim 3 the preparation method of the adaptogen preparation of Radix Rhodiolae, it is characterized in that, comprise the following steps:
(a), by proportioning, take each component and carry out cleaning treatment;
(b), add drinking water and decoct extraction, extracting solution concentrates, and makes concentrated solution;
(c), concentrated solution adds adjuvant, soft material processed sieve granulation, be dried, granulate, make dry granule; Or extract concentrated solution and add adjuvant, through one-step-granulating method, make dry granule; Or concentrated solution drying and crushing sieves and make extract powder, then add adjuvant, soft material processed sieve granulation, dry, granulate, make dry granule.
(d), packing.
7. the preparation method of the adaptogen preparation containing Radix Rhodiolae as described in claim 4 or 5, is characterized in that, comprises the following steps:
(a), by proportioning, take each component and sieve;
(b), each extract mix homogeneously is obtained to total mixture;
(c), in total mixture, add adjuvant, soft material processed sieve granulation, dry, granulate, make dry granule; Or add adjuvant in total mixture, through one-step-granulating method, make dry granule;
(d), packing.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107006856A (en) * | 2017-04-04 | 2017-08-04 | 陈霞 | One kind enhancing endurance, raising anti anoxia tolerance nutritional agents and preparation method thereof |
| CN108576829A (en) * | 2018-05-09 | 2018-09-28 | 哈尔滨工业大学 | One kind fight flood and relieve victims personnel it is special it is antifatigue stress chewable tablets and preparation method thereof |
| CN112955164A (en) * | 2018-09-24 | 2021-06-11 | 托伦哥白尼大学 | Composition with adaptogen activity based on acanthopanax senticosus extract and preparation method thereof |
| RU2774575C2 (en) * | 2021-07-15 | 2022-06-21 | Антон Станиславович Кудрин | Method for obtaining the author's biologically active pharmacological energy, adaptogene, biostimulating emulsion composition used in the 1st half of the day, consisting of: -methixanthines, -ginsenosides a,b,c,d,f, -farnesene, -panaxiol, -panaxitriol, -eleutherosides a,b,c,d,e,f, -gum, -lipids, -coumarin, -salidroside, -rosin, -rosavin, -rosarin, -rhodioline, -astragalin, -citral, -geranyl, -geraniol, -tannins, -schizandrin, -schizandrol, -pinenes, -enantiomers of limonene |
| CN117018133A (en) * | 2023-08-17 | 2023-11-10 | 红云制药(贵州)有限公司 | Continuous preparation method of lung-benefiting cough-relieving capsule |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107006856A (en) * | 2017-04-04 | 2017-08-04 | 陈霞 | One kind enhancing endurance, raising anti anoxia tolerance nutritional agents and preparation method thereof |
| CN108576829A (en) * | 2018-05-09 | 2018-09-28 | 哈尔滨工业大学 | One kind fight flood and relieve victims personnel it is special it is antifatigue stress chewable tablets and preparation method thereof |
| CN112955164A (en) * | 2018-09-24 | 2021-06-11 | 托伦哥白尼大学 | Composition with adaptogen activity based on acanthopanax senticosus extract and preparation method thereof |
| RU2774575C2 (en) * | 2021-07-15 | 2022-06-21 | Антон Станиславович Кудрин | Method for obtaining the author's biologically active pharmacological energy, adaptogene, biostimulating emulsion composition used in the 1st half of the day, consisting of: -methixanthines, -ginsenosides a,b,c,d,f, -farnesene, -panaxiol, -panaxitriol, -eleutherosides a,b,c,d,e,f, -gum, -lipids, -coumarin, -salidroside, -rosin, -rosavin, -rosarin, -rhodioline, -astragalin, -citral, -geranyl, -geraniol, -tannins, -schizandrin, -schizandrol, -pinenes, -enantiomers of limonene |
| CN117018133A (en) * | 2023-08-17 | 2023-11-10 | 红云制药(贵州)有限公司 | Continuous preparation method of lung-benefiting cough-relieving capsule |
| CN117018133B (en) * | 2023-08-17 | 2024-01-30 | 红云制药(贵州)有限公司 | Continuous preparation method of lung-benefiting cough-relieving capsule |
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Application publication date: 20141203 |