CN101040713A - Health-care food having functions of oxidation resisting and immunity improving - Google Patents
Health-care food having functions of oxidation resisting and immunity improving Download PDFInfo
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Abstract
The invention relates to a health food having the functions of oxidation resistance and immunity enhancement, which is prepared from grape seeds, green tea, blueberry, tomato, kudzu vine root, ginseng, gynostemma pentaphylla, astragalus root, ganoderma lucidum and matrimony vine through extraction by water or organic solvent, returning flow, organic solvent extracting, mixing and preparing proportionally, and charging auxiliary materials. The food can be prepared into various dose forms including powders, tablets, capsules or oral liquids.
Description
Technical field
The invention belongs to the preparation of health food, be meant a kind of anti-oxidant, as to strengthen immunity function health food and preparation method thereof that has especially.
Background technology
Aging is a kind of physiological phenomenon that each organ dysfunction of human body begins progressively to reduce, and is the process that the human body total system is degenerated, and comprises immune system, the circulatory system, nervous system, hematological system etc.Can follow the generation of various diseases in the old and feeble process, wherein functions of immune system is low, more can directly increase the ill risk of each internal organs of human body.Cause a major reason of human senility to be, in the metabolic process of human body cell, by the accessory substance that self produced---the too much deleterious cellular effects that causes of oxygen radical, cell is subjected to the attack of oxygen radical, cause the variation of structure and function, long-term accumulation causes the aging of cell and even human body.Be directed to person in middle and old age's domestic health products at present, also be in low-level repetition, the stage of exaggerated propaganda, health food mostly is the health product at one or two physical signs, but be not directed to person in middle and old age's general character health problem (as cardiovascular and cerebrovascular disease, cancer, diabetes, hypopsia etc.), and the product that a plurality of target organs are acted on simultaneously.This deviates from mutually with the market demand that progressively improves and constantly enlarge of physical-fitness medicine research level both domestic and external, therefore, in today that astogeny Community health problem is on the rise, the health food anti-oxidant, that strengthen immunity of exploitation high-tech content is very urgent to reduce the ill risk of person in middle and old age.
Summary of the invention
The object of the present invention is to provide a kind of anti-oxidant, as to strengthen immunity function health food and preparation method thereof that has.
Overall technology design of the present invention is:
A kind of have anti-oxidant, as to strengthen an immunity function health food, contains the component of following weight portion:
Grape seed extract 10-20
Green-tea extract 8-15
Bilberry fruit P.E 20-35
Tomato extract 4-8
Kudzu root extract 15-25
Ginseng extract 2-6
Herb Gynostemmae Pentaphylli extract 5-10
Astragalus Root P.E 5-10
Ganodenna Lucidum P.E 4-8
Wolfberry fruit extract 8-15
This has anti-oxidant, as to strengthen the health food of immunity function preparation method, comprises following processing step:
(1) preparation of extract:
A, grape seed extract: dry behind the benzinum soak degreasing after dried grape pip pulverizing, in 40-60 ℃ of water-bath, acetone with 80% extracted 30-60 minute grape pip, stage extraction under different temperatures afterwards, cooling, suction filtration, vacuum concentrates, and gets extract powder;
B, green-tea extract: with the lixiviate in 85-95 ℃ of hot water of dry green tea, filtration, priority ethyl acetate extracting twice, merge organic facies, use anhydrous Na then
2SO
4Drying, decompression distillation remove desolvate green-tea extract;
C, Bilberry fruit P.E: after raw material smashed to pieces, use the acidic methanol extracting, after 80-100 ℃ of extracting 10-20 minute, be dried to powder then;
D, tomato extract: after tomato drying, pulverizing, extract as extract, then the extract vacuum is concentrated, obtain tomato extract with chloroform;
E, kudzu root extract: after raw material pulverizing, at temperature 80-90 ℃, the pH value is under 8 the condition, and doubly to root of kudzu vine weight, the ethanol of 70-90% leaches 2 times with 6-10, each 3 hours, merge extract then, and dealcoholysis is through the vacuum drying powdered;
F, ginseng extract: genseng is pulverized, is added the alcohol immersion 12 hours of excessive 50%-60%, carry out the heating for multiple times refluxing extraction, phegma is concentrated back recovery ethanol, concentrate drying powdered then;
G, Herb Gynostemmae Pentaphylli extract: air-dry gynostemma pentaphylla cauline leaf is pulverized, and the alcohol extract with 40%-60% merges extract after twice extracting, and dealcoholysis then makes saponin(e through behind the drying under reduced pressure;
H, Astragalus Root P.E: the Radix Astragali is pulverized, with lixiviate in the 90-100 ℃ of hot water 3 times, each 1-2 hour, merging filtrate also transfers to neutral concentrating, and adds ethanolic solution and separates, and filter the back that is dissolved in water, and concentrated filtrate, the ethanol that adds 60-80% repeatedly washs, and concentrated spray is dried to powder;
I, Ganodenna Lucidum P.E: with the glossy ganoderma thalline, put into 90-100 ℃ of water lixiviate, one time 2-3 hour, lixiviate is 3 times continuously, merges 3 times water extract decompression, concentrates, and 95% ethanol with 3 times of volumes mixes again, left standstill 10-12 hour, centrifugal, the ethanol that adds 70-90% at last washs, and concentrated spray is dried to powder;
J, wolfberry fruit extract: with 60-90 ℃ of benzinum backflow degreasing secondary of matrimony vine powder, alcohol reflux with 60%-80% extracts secondary again, and the dregs of a decoction are extracted secondaries with 90 ℃ of water-baths, merge secondary raffinate then, check concentrates, filters, and filtrate is added excessive 80-95% ethanol, after this ethanol of the precipitation behind the suction filtration through 80-95% is repeatedly washed, 60 ℃ of dryings, get wolfberry fruit extract;
(2) after each extract that step (1) is prepared is mixed evenly in proportion, make powder.
This has after anti-oxidant, as to strengthen immunity function health food can also each as required that step (1) is prepared extract be mixed evenly in proportion, adds auxiliary material, is prepared into tablet, electuary, capsule, oral liquid.
The main effect of each component is among the present invention:
One, turns to main component compound basis with antioxygen
1, grape seed extract
The main functional component of grape seed extract is an OPC, and modern medicine study shows that the ability anti-oxidant, that remove free radical of OPC in human body is V
E50 times, 20 times of Vc.Pharmacology and clinical studies result point out that OPC has the effect of anti-cardiovascular disease simultaneously, comprising anti-hypertension, regulate blood fat, anti-arteriosclerosis, protection cardiac muscle cell, the effect of anti-ischemia reperfusion injury.In addition, also has neuroprotective unit, antitumor protective effect on cancer risk, anti-aging effects.In recent years studies show that OPC can also prevent and treat that visual performance is low, allergic, the multiple disease that causes because of free radical such as SOA, gastric ulcer, arthritis.
2, Bilberry fruit P.E
The main functional component of Bilberry fruit P.E is an anthocyanin.United States Department of Agriculture nutrition center claims, cowberry is the abundantest a kind of of oxidation resistance in more than the 40 kind of fruits and vegetables of being studied.The main active of Bilberry fruit P.E is an anthocyanin.Correlative study shows that the water-soluble anthocyanin in the cowberry has very strong antioxidation activity, delay senility in addition in addition, anticancer, suppress the effect of platelet aggregation (prevention thrombosis), and can effectively prevent illnesss such as cerebral diseased, artery sclerosis.Long-term edible anthocyanin can promote erythrolabe synthetic again on the retina, assists to remove intraretinal toxic chemical substance, and free radical etc. are eliminated asthenopia.
3, green-tea extract
The main functional component of green-tea extract is a Tea Polyphenols.Tea Polyphenols has wide biological activity, and it is antioxidation efficiently, and the multiple prevention from suffering from the diseases and the treatment of human body played significant role.Studies show that Tea Polyphenols has effects such as anti-arteriosclerosis, antitumor, antiallergy, anti-inflammation, protection cell, anti-sudden change.Zoopery shows that the main active substances catechu in the Tea Polyphenols have and alleviates liver, ephrosis reason damaging action.
4, tomato extract
The main functional component of tomato extract is a lycopene.The clinical epidemiology in recent two decades west studies show that the content of lycopene in the human body is crossed low relevant with the generation of chronic disease such as coronary heart disease and tumour etc., can prevent the generation or the development of these chronic diseases and take in lycopene.Modern medicine study shows, because the strong antioxidant action of lycopene, makes its heart, cerebrovascular disease at the control oxidative damage, and there is remarkable effect aspects such as old and feeble and skin injury, has immunological regulation, pharmacological function such as antitumor in addition.
5, kudzu root extract
The main functional component of kudzu root extract is a kudzu root flavone.Through the modern medicine scientific research, its pharmacological function and clinical effect are determined.Kudzu root flavone has anti-oxidant, raising immunity as a kind of osajin phytoestrogen.Studies show that in recent years, kudzu root flavone all have certain prevention and therapeutic action as angiocardiopathy, mammary gland, prostatic disorders, additional matter osteoporosis with the tumour relevant with sex hormone to some common person in middle and old age's diseases.
Two, to improve the component compound basis of immunity
1, ginseng extract
The main functional component of ginseng extract is a panaxoside.In recent years the biologically active that studies show that panaxoside all is to make body function normalization, and brings into play anti-aging effects and be used for the treatment of disease of old people.The many-sided research of Chinese scholars by panaxoside is carried out is found that panaxoside has wide biological activity to human immune system, nervous system, cardiovascular system, internal system etc., and and is widely used in clinical practice.
2, Herb Gynostemmae Pentaphylli extract
The main functional component of Herb Gynostemmae Pentaphylli extract is a gynosaponin.Gynosaponin has the ability that strengthens immunity of organisms widely, and can suppress rejection.Has reducing blood lipid simultaneously, treatment artery sclerosis, anti thrombotic action.In addition, gynosaponin has the function that alleviates liver, the rational damage of ephrosis.
3, Astragalus Root P.E
The main functional component of Astragalus Root P.E is an astragalus polyose.Astragalus polyose has regulating action widely to body immune system, as strengthen peritoneal macrophage, bone-marrow-derived lymphocyte and NK cell activity, promote immune factors such as IL-2, TNF and INF to produce, promote the lymphocytic enhancing of T to transform, thereby reach the immune defense function of comprehensive raising body.Simultaneously astragalus polyose also has significant antioxidant role, antitumor action, and the damage of cardiovascular system, liver, kidney is had protective effect.
4, Ganodenna Lucidum P.E
The main functional component of Ganodenna Lucidum P.E is a GL-B.GL-B is a kind of biological immunomodulator, can strengthen the cellular immunity and the humoral immunity of body, and modulation on immune status is played a part bidirectional modulation.It mainly shows four aspects: (1) stimulates phagocytosis of macrophages; (2) stimulate the B cell to produce antibody; (3) promote T cell proliferation; (4) effect that mixed lymphocytes is cultivated.Multinomial research shows that also GL-B has obvious effect in antitumor, antioxidant radical, antithrombotic, reducing blood lipid, aspect hypoglycemic and anti-ageing.
5, wolfberry fruit extract
The main functional component of wolfberry fruit extract is a LBP-X.Clinical research shows that LBP-X has the phagocytic function that improves macrophage significantly, improves the lymphocytic multiplication capacity of T, increases serum IgG content, strengthens the effect of specific immunity.Experimental study proof LBP-X protect the liver with anti peroxidation of lipid, anti-cancer and inhibiting tumor, anti-ageing, promote learning memory to play good prevention effect in recovering.
The present invention is the compatibility by different active components just; make the various active composition in different levels; act on same target organ or a plurality of target organ and bring into play synergy, to reach functional protection effect and prevention from suffering from the diseases effect each system of middle-aged and old body.Selecting for use of each active ingredient meets national relevant policies, shows through test and experiment, and it is nontoxic that this has anti-oxidant, as to strengthen an immunity function health food.
Substantive distinguishing features that the present invention possessed and the remarkable technological progress that obtains are:
Can realize the various active composition effectively in different levels, act on same target organ or a plurality of target organ and bring into play synergy, to reach functional protection effect and prevention from suffering from the diseases effect each system of middle-aged and old body.Improve physiological active functions, and fully guaranteed the active function definition of each functional component.Present health food kind effect instability, the agnogenic difficult problem of effect have been solved.Free of contamination water, alcohol extracting technology are mainly adopted in the preparation of each extract among the preparation method of the present invention, have avoided generation residual contaminations such as use macroreticular resin.
The specific embodiment
Below in conjunction with embodiment the present invention is described further:
Embodiment 1
The active princlple that contains following weight portion in the present embodiment:
Grape seed extract 15
Green-tea extract 10
Bilberry fruit P.E 27
Tomato extract 5
Kudzu root extract 18
Ginseng extract 3
Herb Gynostemmae Pentaphylli extract 7
Astragalus Root P.E 8
Ganodenna Lucidum P.E 6
Wolfberry fruit extract 11
The preparation method of present embodiment is as follows:
(1) preparation of extract:
A, grape seed extract: dry behind the benzinum soak degreasing after dried grape pip pulverizing, in 50 ℃ of water-baths, the acetone with 80% extracted 45 minutes grape pip, stage extraction under different temperatures afterwards, and cooling, suction filtration, vacuum concentrates, and gets extract powder;
B, green-tea extract: with the lixiviate in 90 ℃ of hot water of dry green tea, filtration, priority ethyl acetate extracting twice, merge organic facies, use anhydrous Na then
2SO
4Drying, decompression distillation remove desolvate green-tea extract;
C, Bilberry fruit P.E: after raw material smashed to pieces, use the acidic methanol extracting, after 15 minutes, be dried to powder then 95 ℃ of extractings;
D, tomato extract: after tomato drying, pulverizing, extract as extract, then the extract vacuum is concentrated, obtain tomato extract with chloroform;
E, kudzu root extract: after raw material pulverizing, 82 ℃ of temperature, the pH value is under 8 the condition, with 8 times to root of kudzu vine weight, 85% ethanol leaches 2 times, each 3 hours, merge extract then, dealcoholysis is through the vacuum drying powdered;
F, ginseng extract: genseng is pulverized, was added excessive 52% alcohol immersion 12 hours, carry out the heating for multiple times refluxing extraction, phegma is concentrated back recovery ethanol, concentrate drying powdered then;
G, Herb Gynostemmae Pentaphylli extract: air-dry gynostemma pentaphylla cauline leaf is pulverized, and the alcohol extract with 50% merges extract after twice extracting, and dealcoholysis then makes saponin(e through behind the drying under reduced pressure;
H, Astragalus Root P.E: the Radix Astragali is pulverized, with lixiviate in 95 ℃ of hot water 3 times, each 1.5 hours, merging filtrate also transfers to neutral concentrating, and adds 75% ethanolic solution separation, and filter the back that is dissolved in water, and concentrated filtrate, the ethanol that adds 60-80% repeatedly washs, and concentrated spray is dried to powder;
I, Ganodenna Lucidum P.E: with the glossy ganoderma thalline, put into 98 ℃ of water lixiviates, one time 2.5 hours, lixiviate is 3 times continuously, merges 3 times water extract decompression, concentrates, and 95% ethanol with 3 times of volumes mixes again, left standstill 11 hours, centrifugal, add the washing of 85% ethanol at last, concentrated spray is dried to powder;
J, wolfberry fruit extract: with the matrimony vine powder with 70 ℃ of benzinum backflow degreasing secondaries, extract secondary with 75% alcohol reflux again, and the dregs of a decoction are extracted secondaries with 90 ℃ of water-baths, merge secondary raffinate then, check concentrates, filters, and filtrate is added 90% excessive ethanol, after this precipitation behind the suction filtration is repeatedly washed through 85% ethanol, 60 ℃ of dryings, get wolfberry fruit extract;
(2) with each prepared in the step (1) extract, proportionally be mixed evenly after, add amylum pregelatinisatum, lactose, microcrystalline cellulose, PVPP, sodium carboxymethyl starch, dolomol, PVP auxiliary material, make tablet through mixing, granulation, oven dry, compressing tablet.
Embodiment 2
The active princlple that contains following weight portion in the present embodiment:
Grape seed extract 11
Green-tea extract 13
Bilberry fruit P.E 28
Tomato extract 7
Kudzu root extract 21
Ginseng extract 5.5
Herb Gynostemmae Pentaphylli extract 8
Astragalus Root P.E 8.5
Ganodenna Lucidum P.E 6
Wolfberry fruit extract 10
The preparation method is with embodiment 1.
Claims (3)
1, a kind of have anti-oxidant, as to strengthen an immunity function health food, it is characterized in that containing the component of following weight portion:
Grape seed extract 10-20
Green-tea extract 8-15
Bilberry fruit P.E 20-35
Tomato extract 4-8
Kudzu root extract 15-25
Ginseng extract 2-6
Herb Gynostemmae Pentaphylli extract 5-10
Astragalus Root P.E 5-10
Ganodenna Lucidum P.E 4-8
Wolfberry fruit extract 8-15.
2, the preparation method with anti-oxidant, as to strengthen immunity function health food according to claim 1 is characterized in that comprising following processing step:
(1) preparation of extract:
A, grape seed extract: dry behind the benzinum soak degreasing after dried grape pip pulverizing, in 40-60 ℃ of water-bath, acetone with 80% extracted 30-60 minute grape pip, stage extraction under different temperatures afterwards, cooling, suction filtration, vacuum concentrates, and gets extract powder;
B, green-tea extract: with the lixiviate in 85-95 ℃ of hot water of dry green tea, filtration, priority ethyl acetate extracting twice, merge organic facies, use anhydrous Na then
2SO
4Drying, decompression distillation remove desolvate green-tea extract;
C, Bilberry fruit P.E: after raw material smashed to pieces, use the acidic methanol extracting, after 80-100 ℃ of extracting 10-20 minute, be dried to powder then;
D, tomato extract: after tomato drying, pulverizing, extract as extract, then the extract vacuum is concentrated, obtain tomato extract with chloroform;
E, kudzu root extract: after raw material pulverizing, at temperature 80-90 ℃, the pH value is under 8 the condition, and doubly to root of kudzu vine weight, the ethanol of 70-90% leaches 2 times with 6-10, each 3 hours, merge extract then, and dealcoholysis is through the vacuum drying powdered;
F, ginseng extract: genseng is pulverized, is added the alcohol immersion 12 hours of excessive 50%-60%, carry out the heating for multiple times refluxing extraction, phegma is concentrated back recovery ethanol, concentrate drying powdered then;
G, Herb Gynostemmae Pentaphylli extract: air-dry gynostemma pentaphylla cauline leaf is pulverized, and the alcohol extract with 40%-60% merges extract after twice extracting, and dealcoholysis then makes saponin(e through behind the drying under reduced pressure;
H, Astragalus Root P.E: the Radix Astragali is pulverized, with lixiviate in the 90-100 ℃ of hot water 3 times, each 1-2 hour, merging filtrate also transfers to neutral concentrating, and adds ethanolic solution and separates, and filter the back that is dissolved in water, and concentrated filtrate, the ethanol that adds 60-80% repeatedly washs, and concentrated spray is dried to powder;
I, Ganodenna Lucidum P.E: with the glossy ganoderma thalline, put into 90-100 ℃ of water lixiviate, one time 2-3 hour, lixiviate is 3 times continuously, merges 3 times water extract decompression, concentrates, and 95% ethanol with 3 times of volumes mixes again, left standstill 10-12 hour, centrifugal, the ethanol that adds 70-90% at last washs, and concentrated spray is dried to powder;
J, wolfberry fruit extract: with 60-90 ℃ of benzinum backflow degreasing secondary of matrimony vine powder, alcohol reflux with 60%-80% extracts secondary again, and the dregs of a decoction are extracted secondaries with 90 ℃ of water-baths, merge secondary raffinate then, check concentrates, filters, and filtrate is added excessive 80-95% ethanol, after this ethanol of the precipitation behind the suction filtration through 80-95% is repeatedly washed, 60 ℃ of dryings, get wolfberry fruit extract;
(2) after each extract that step (1) is prepared is mixed evenly in proportion, make powder.
3, the preparation method with anti-oxidant, as to strengthen immunity function health food according to claim 2, after it is characterized in that each extract that step (1) is prepared is mixed evenly in proportion, add auxiliary material, be prepared into tablet, electuary, capsule, oral liquid.
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