CN105232384A - Anti-aging lycium barbarum skin-care product - Google Patents

Abstract

The invention relates to an anti-aging lycium barbarum skin-care product, and also provides a preparation method of a preferred lycium barbarum extract. The lycium barbarum extract prepared by the method can play a relatively good anti-aging effect, and serves as the main active ingredient to be applied to anti-aging cosmetics for the first time, and the optimal selection of various additives and the optimal ratio of all components are determined through prescription screening, so that the obtained skin-care product is exquisite and mild, good in spreadability and excellent in consumer experience.

Description

A kind of Fructus Lycii anti-aging skin care product

Technical field

The present invention relates to detergents and cosmetic cosmetic field, be specifically related to a kind of Fructus Lycii anti-aging skin care product.

Background technology

Fructus Lycii (LyciumchinenseMill.) begins the Shennong's Herbal be loaded in before more than 2,000 year, and be listed in top grade, effects such as " taking for a long time; hard muscle ... mend vital essence various symptoms and signs of deficiency; improving eyesight is calmed the nerves; make us long-lived " that Ming Dynasty's Li Shizhen (1518-1593 A.D.) is recorded Fructus Lycii and had in Compendium of Material Medica, application has Fructus Lycii, sky essence grass, Cortex Lycii, this three to be the fruit of Fructus Lycii, leaf and root bark respectively clinically.Lycium about 80 kinds, is under the jurisdiction of Solanaceae (Solanaceae), is mainly distributed in south, North America, forms Liang Ge distribution center with the Arizona State of the U.S. and Argentina, but is that Eurasia has 10 kinds at most with South America; China has 7 kinds, 3 mutation, is distributed in THE SOUTH OF NORTHEAST CHINA, North China, northwest to the ground such as south China, southwest more; Also there are cultivation in Korea, Japan.

Fructus Lycii is mainly containing lycium barbarum polysaccharide, betanin, carotenoid and carotenoid ester, VC, scopoletin, several amino acids and the composition such as elements K, Na, Ca, Mg, Cu, Fe, Mn, Zn, P.Modern pharmacology study general thinks that the bioactive ingredients in Fructus Lycii can be summarized as 3 main aspects: 1. abundant in wolfberry pigment carotenoid; 2. betanin, plays methyl supplying in vivo, can promote lipid metabolism, has lipotropic effect; 3. lycium barbarum polysaccharide, is a kind of nonspecific immunostimulant, can improves body's immunity, strengthens resistance against diseases, thus reaches the effects such as defying age, anticancer, anti-lonizing radiation, anti-hepatitis and AIDS resisting.

Fructus Lycii nature and flavor are sweet flat, return liver, kidney channel, have effect of nourishing liver and kidney, replenishing vital essence to improve eyesight, cure mainly asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat are quenched one's thirst, blood deficiency and yellow complexion, blurred vision are not clear.Modern medicine proves, Fructus Lycii mainly has following biological activity: (1) delaying senility function, Fructus Lycii increases leukocyte and Neutrophil numbers, strengthen the phagocytic function of macrophage, improve the biosynthesis of splenocyte nucleic acid and protein, promote the generation of interleukin II, promote marrow hemopoietic stem cells propagation, suppress the generation of lipid peroxide, improve the activity of glutathion peroxidase and superoxide dismutase, and there is the effect of plan choline-like, reduce serum cholesterol, suppress arteriosclerosis etc.; (2) antitumor action, Japanese scholars 1979 report, Folium Lycii and fruit have inhibitory action to the cancerous cell of In vitro culture, and China also finds lycium barbarum leaf, really, fruit stem can produce growth inhibitory effect in various degree to two kinds of human cancer cells; (3) increase immunization, lycium barbarum polysaccharide can activated T lymphocytes and bone-marrow-derived lymphocyte, to strengthen cellular immunization, also can strengthen humoral immune function simultaneously; (4) hepatoprotective effect, the Radix Betae alkali salt in Fructus Lycii can make the phospholipid in rat blood serum regulating liver-QI obviously increase, and gives rat phospholipid caused by carbon tetrachloride to decline and cholesterol raises and has significant protective effect to long expiration; (5) hypoglycemic activity, lycium barbarum polysaccharide all has hypoglycemic activity to normal and diabetic animal models, and its hypoglycemic activity is mainly by promoting that beta Cell of islet uelralante produced; (6) effect for reducing blood fat, the blood fat of lycium barbarum polysaccharide to Experimental Hyperlipemia Rabbits has a significant effect, and significantly can reduce serum cholesterol and triacylglycerol content, blood fat reducing effective percentage reaches 100%.

Also usual in prior art Fructus Lycii to be used in cosmetics, but there is not been reported for anti-aging cosmetics to it can be used as main component.Thus, how to make full use of the nutritive value of Fructus Lycii, provide its utilization rate, exploitation has the cosmetics new product of senile-resistant efficacy, meets and enriches the growing material requisite of people, significant.

Summary of the invention

The object of the invention is to overcome above-mentioned defect, provide a kind of Fructus Lycii anti-aging skin care product, it is using wolfberry fruit extract as main activity of fighting against senium composition, has excellent senile-resistant efficacy.

The technical scheme that the present invention solves this technical problem is:

A kind of Fructus Lycii anti-aging skin care product, is made up of following compositions in weight percentage:

Wolfberry fruit extract 20-30

Glycerol 10-20

Spermol 10-20

Sodium stearoyl lactate 5-10

Silicone oil 5-10

Retinol 1-2

Adermykon 1-2

Methyl parahydroxybenzoate 0.1-0.2

Fragrance qs

Purified water to 100%.

Preferably, be made up of following compositions in weight percentage:

Wolfberry fruit extract 25

Glycerol 20

Spermol 18

Sodium stearoyl lactate 10

Silicone oil 10

Retinol 2

Adermykon 1

Methyl parahydroxybenzoate 0.2

Fragrance qs

Purified water to 100%.

The preparation method of described wolfberry fruit extract is: Fructus Lycii drying ground, be placed in reflux, add chloroform-n-butyl alcohol (5:1) 20mL/ time, reflux defat 3 times at 60 DEG C, each 1h, leach solvent, 60% ethanol is added 20mL/ time after residue is air-dry, 60 DEG C of backflows 3 times, each 1h, reclaim ethanol, again with 60 DEG C of solid-to-liquid ratios for 1:(10-15) distilled water extraction 3 times, each 1h, merging filtrate concentrates, with 95% alcohol settling of 5 times amount, place 24h, sucking filtration, products therefrom uses 95% ethanol successively, dehydrated alcohol, washing with acetone, vacuum drying, obtain.

The solid-to-liquid ratio of described distilled water extraction is preferably 1:15.

Invention also provides the preparation method of above-mentioned Fructus Lycii anti-aging skin care product, its operating procedure is:

(1) by formula ratio by glycerol, spermol, silicone oil, retinol and adermykon in 75 DEG C heating mix homogeneously;

(2) by formula ratio, wolfberry fruit extract, sodium stearoyl lactate and purified water are heated mix homogeneously in 75 DEG C;

(3) by step (1) and the mixing of step (2) gained mixture, add methyl parahydroxybenzoate and essence, stir, cooling, to obtain final product.

Beneficial effect of the present invention:

(1) the present invention provides wolfberry fruit extract first as the application of main active in anti-aging cosmetics, and provides the preparation method of preferred wolfberry fruit extract, and thus obtained extract can play good senile-resistant efficacy.

(2) the present invention determines the optimum selection of various additive and the optimum proportioning of each component by prescription screening, and thus obtained skin care item exquisiteness is soft, and spreadability is good, and consumer experience is good.

Detailed description of the invention

Below in conjunction with specific embodiment, set forth the present invention further.Should be understood that these embodiments are only not used in for illustration of the present invention to limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example, the usually conveniently conditioned disjunction condition of advising according to manufacturer.Unless otherwise indicated, otherwise all percent, ratio, ratio or number by weight.

Unless otherwise defined, all specialties used in literary composition and scientific words and one skilled in the art the same meaning be familiar with.In addition, any method similar or impartial to described content and material all can be applicable in the inventive method.The use that better implementation method described in literary composition and material only present a demonstration.

Embodiment 1:

Fructus Lycii drying is ground, be placed in reflux, add chloroform-n-butyl alcohol (5:1) 20mL/ time, reflux defat 3 times at 60 DEG C, each 1h, leach solvent, 60% ethanol is added 20mL/ time after residue is air-dry, 60 DEG C of backflows 3 times, each 1h, reclaim ethanol, again with 60 DEG C of solid-to-liquid ratios distilled water extraction that is 1:10 3 times, each 1h, merging filtrate concentrates, with 95% alcohol settling of 5 times amount, place 24h, sucking filtration, products therefrom uses 95% ethanol, dehydrated alcohol, washing with acetone successively, vacuum drying, obtains wolfberry fruit extract;

Take each component as following weight percent:

Wolfberry fruit extract 20

Glycerol 15

Spermol 18

Sodium stearoyl lactate 10

Silicone oil 8

Retinol 2

Adermykon 2

Methyl parahydroxybenzoate 0.2

Fragrance qs

Purified water to 100%;

By glycerol, spermol, silicone oil, retinol and adermykon are in 75 DEG C of heating mix homogeneously; By wolfberry fruit extract, sodium stearoyl lactate and purified water in 75 DEG C of heating mix homogeneously; Both mixed, add methyl parahydroxybenzoate and essence, stir, cooling, to obtain final product.

Embodiment 2:

Fructus Lycii drying is ground, be placed in reflux, add chloroform-n-butyl alcohol (5:1) 20mL/ time, reflux defat 3 times at 60 DEG C, each 1h, leach solvent, 60% ethanol is added 20mL/ time after residue is air-dry, 60 DEG C of backflows 3 times, each 1h, reclaim ethanol, again with 60 DEG C of solid-to-liquid ratios distilled water extraction that is 1:15 3 times, each 1h, merging filtrate concentrates, with 95% alcohol settling of 5 times amount, place 24h, sucking filtration, products therefrom uses 95% ethanol, dehydrated alcohol, washing with acetone successively, vacuum drying, obtains wolfberry fruit extract;

Take each component as following weight percent:

Wolfberry fruit extract 25

Glycerol 20

Spermol 18

Sodium stearoyl lactate 10

Silicone oil 10

Retinol 2

Adermykon 1

Methyl parahydroxybenzoate 0.2

Fragrance qs

Purified water to 100%;

By glycerol, spermol, silicone oil, retinol and adermykon are in 75 DEG C of heating mix homogeneously; By wolfberry fruit extract, sodium stearoyl lactate and purified water in 75 DEG C of heating mix homogeneously; Both mixed, add methyl parahydroxybenzoate and essence, stir, cooling, to obtain final product.

Embodiment 3:

Fructus Lycii drying is ground, be placed in reflux, add chloroform-n-butyl alcohol (5:1) 20mL/ time, reflux defat 3 times at 60 DEG C, each 1h, leach solvent, 60% ethanol is added 20mL/ time after residue is air-dry, 60 DEG C of backflows 3 times, each 1h, reclaim ethanol, again with 60 DEG C of solid-to-liquid ratios distilled water extraction that is 1:12 3 times, each 1h, merging filtrate concentrates, with 95% alcohol settling of 5 times amount, place 24h, sucking filtration, products therefrom uses 95% ethanol, dehydrated alcohol, washing with acetone successively, vacuum drying, obtains wolfberry fruit extract;

Take each component as following weight percent:

Wolfberry fruit extract 30

Glycerol 10

Spermol 10

Sodium stearoyl lactate 5

Silicone oil 5

Retinol 1.5

Adermykon 1.5

Methyl parahydroxybenzoate 0.1

Fragrance qs

Purified water to 100%;

By glycerol, spermol, silicone oil, retinol and adermykon are in 75 DEG C of heating mix homogeneously; By wolfberry fruit extract, sodium stearoyl lactate and purified water in 75 DEG C of heating mix homogeneously; Both mixed, add methyl parahydroxybenzoate and essence, stir, cooling, to obtain final product.

Embodiment 4: the Antisenility Experiment of Fructus Lycii defying age extract

Experimental principle: lipid peroxide (LPO) is the peroxide that unsaturated fatty acid is formed through Free Radical, the rising of its content can cause all damages to the structure of cell and cell membrane or function, it is relevant with aging with the index such as superoxide dismutase and oxygen-derived free radicals, can Immunosuppression function.

Superoxide dismutase (SOD) is antioxidase important in body, its can scavenging free radicals to the toxic action of body, enhance SOD activity can reduce the generation of LPO in body, removes the infringement that interior free yl causes, thus reduces generation and the slow down aging of disease.

Collagen protein is the main component forming connective tissue cell interstitial collagen fiber, old people and geriatric animals collagen protein dissolubility increase with the age and reduce gradually, hydroxyproline (HO-Pro) content of collagen protein body free peptide or binding peptide reduces, HO-Pro and Animal Aging also exist dependency, can detect the aging aspects of animal by measuring HO-Pro.

Experimental technique: get Aged Mice 40, be divided into 4 groups at random, often organize 10, gavage the wolfberry fruit extract 100mg/kg of embodiment 1-3 respectively, normal saline 0.5mL/, under equal conditions, feed continuous 30 days, after last administration, eye socket blood sampling in 2 hours, measures SOD and LPO content, gets tail eyelash and measure HO-Pro content after putting to death mice.Result is as shown in table 1:

Table 1 Fructus Lycii defying age extract is on the impact of Aged Mice SOD, LPO, HO-PRO

	SOD(u/ghb)	LPO(mol/ml)	HO-Pro(mg/5mg)
				Normal saline group	1243	8.24	3.16
Embodiment 1	2512	4.21	5.12
				Embodiment 2	2432	4.08	5.31
Embodiment 3	2533	4.33	5.08

Meanwhile, get mice 40, be divided into 4 groups at random, often organize 10, gavage the wolfberry fruit extract 100mg/kg of embodiment 1-3 respectively, normal saline 0.5mL/ only, under equal conditions, feed continuous 30 days, carry out endurance mensuration respectively, bear a heavy burden according to 15% of Mouse Weight, in depth of water 60cm, the water went swimming of water temperature 22 DEG C, sinks under water with mice and no longer floats for index, measure their swimming time.Result is as shown in table 2:

Table 2 Fructus Lycii defying age extract is on the impact of mice swimming time

	Normal saline group	Embodiment 1	Embodiment 2	Embodiment 3
					Swimming time (s)	43.9	89.9	91.2	90.3

Result shows, Fructus Lycii defying age extract of the present invention significantly can reduce LPO level in Aged Mice serum, improve SOD in Aged Mice erythrocyte active, mice can be extended simultaneously and improve endurance, extend mice swimming time, thus effectively can remove the infringement that interior free yl causes, thus reduce generation and the slow down aging of disease.

The foregoing is only preferred embodiment of the present invention, and be not used to limit substantial technological context of the present invention, substantial technological content of the present invention is broadly defined in the right of application, any technology entities that other people complete or method, if with application right define identical, also or a kind of change of equivalence, be all covered by being regarded as among this right.

Claims (5)

1. a Fructus Lycii anti-aging skin care product, is characterized in that, is made up of following compositions in weight percentage: wolfberry fruit extract 20-30

Glycerol 10-20

Spermol 10-20

Sodium stearoyl lactate 5-10

Silicone oil 5-10

Retinol 1-2

Adermykon 1-2

Methyl parahydroxybenzoate 0.1-0.2

Fragrance qs

Purified water to 100%.

2. Fructus Lycii anti-aging skin care product according to claim 1, is characterized in that, is made up of following compositions in weight percentage:

Wolfberry fruit extract 25

Glycerol 20

Spermol 18

Sodium stearoyl lactate 10

Silicone oil 10

Retinol 2

Adermykon 1

Methyl parahydroxybenzoate 0.2

Fragrance qs

Purified water to 100%.

3. Fructus Lycii anti-aging skin care product according to claim 1 and 2, it is characterized in that, the preparation method of described wolfberry fruit extract is: Fructus Lycii drying ground, be placed in reflux, add chloroform-n-butyl alcohol (5:1) 20mL/ time, reflux defat 3 times at 60 DEG C, each 1h, leach solvent, 60% ethanol is added 20mL/ time after residue is air-dry, 60 DEG C of backflows 3 times, each 1h, reclaim ethanol, again with 60 DEG C of solid-to-liquid ratios for 1:(10-15) distilled water extraction 3 times, each 1h, merging filtrate concentrates, with 95% alcohol settling of 5 times amount, place 24h, sucking filtration, products therefrom uses 95% ethanol successively, dehydrated alcohol, washing with acetone, vacuum drying, obtain.

4. Fructus Lycii anti-aging skin care product according to claim 3, is characterized in that, the solid-to-liquid ratio of described distilled water extraction is preferably 1:15.

5. the preparation method of the Fructus Lycii anti-aging skin care product according to any one of claim 1-4, is characterized in that, its operating procedure is:

(1) by formula ratio by glycerol, spermol, silicone oil, retinol and adermykon in 75 DEG C heating mix homogeneously;

(2) by formula ratio, wolfberry fruit extract, sodium stearoyl lactate and purified water are heated mix homogeneously in 75 DEG C;

(3) by step (1) and the mixing of step (2) gained mixture, add methyl parahydroxybenzoate and essence, stir, cooling, to obtain final product.