CN109247585A - A kind of full nutrition special medicine purposes formula food for trauma patient - Google Patents
A kind of full nutrition special medicine purposes formula food for trauma patient Download PDFInfo
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A23L33/16—Inorganic salts, minerals or trace elements
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A23L33/19—Dairy proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
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Abstract
The invention discloses a kind of full nutrition special medicine purposes formula foods for trauma patient, it is grouped as by each group of following mass percent: ocean Isin glue collagen peptide 6-7%, gadus albumen oligopeptide 6-7%, lactalbumin 8-10%, plant oil powder 12-13%, maltodextrin 28-30%, isomalt 23-25%, dietary fiber 5-6%, minerals 2.2-2.22%, vitamin 0.098-0.103%, moisture 3-4%.The present invention is using ocean Isin glue collagen peptide, gadus albumen oligopeptide as matrix, creatively as the nutritional ingredient of nitrogen source, special medicine purposes formula food of the research and development for wound, infection, operation and other stress situations, the negative nitrogen balance that patient's body will fundamentally be corrected, improves the symptoms such as nutrient absorption is bad.
Description
Technical field
The invention belongs to Medical Nutritional technical fields, and in particular to a kind of full nutrition special medicine use for trauma patient
Way formula food.
Background technique
The stress situations such as wound, infection and operation have tremendous influence to human health, deal with improperly will lead to high fever,
Symptoms, the serious person such as swell and ache, fester can cause the serious consequences such as tissue necrosis, stupor, shock, systemic toxicity, even result in
The death of patient.Body will appear a series of metabolic alterations after trauma stress, shows as rest energy expenditure (REE) and increases, is high
Blood glucose, gluconeogenesis enhancing, breaks down proteins enhancing, lipid mobilization are accelerated, under negative nitrogen balance and body cell aggregate level
Drop.Body will appear neuroendocrine function in trauma stress, cell factor generates and the change of metabolism, can have metabolism high
Into the net decomposition of protein is higher than net synthesis, and as a result body repairs group without enough energy, nitrogen source and other nutrients etc.
It knits.
Currently, mainly being coped with by means such as physiotherapy, drug therapy, medical dressing in China's clinical treatment postoperative
The problems such as healing, skin trauma, tissue infection.But physical chemistry treatment can all bring corresponding toxic side effect to body, and
External application auxiliary material does not also act on the improvement of nutrition situation and the adjusting of internal nitrogen balance.And all wounds, infection,
Often there is Disorder of Digestion and A orption in the patient of operation and other stress situations, and underfed situation is caused to take place frequently, if these
Patient is malnutritive, and wound cannot cure at all.Thus it is guaranteed that the nutrition intake of patient, especially using polypeptide as functional component
Nitrogen source intake, be the basic guarantee of Rehabilitation.
104171798 A of patent of invention CN discloses a kind of wound, infection, operation and the full nutrition of other stress situations and matches
Square food, full nutrition formula food, specific full nutrient formulation for wound, infection, operation and other stress situation edible for patients
Food or non-whole nutritional formula food.The formula in conjunction with wound, is felt according to the requirement of " special medicine purposes formula food general rule "
The constitutive character of dye, operation and other stress situations patient, advanced physiology, the medicine, battalion of comprehensive nowadays American Harvard University
Support and learn and the research achievements such as clinical application, the marrow of the Traditional Chinese Medicine according to " middle residence that disappears is mended ", " balanced tone " it is theoretical (liver, spleen,
The dirty people having the same aspiration and interest of kidney three is main principle) it develops.The product uses the Chinese medical extract essence of 10 kinds or more dual-purpose of drug and food, Duo Zhongyi
Raw bacterium, prebiotics are primary raw material, with small peptide, amino acid, water-soluble dietary fiber, multi-vitamins, composite mineral matter auxiliary material,
It can be used as single source of nutrition and meet wound, infection, operation and the nutritional need of other stress situations patient, also play
Activating microcirculation and removing stasis medicinal is removed necrosis and promoted granulation, effect that bowl spares qi-regulating, dysmenorrhea are active.
On Vehicles Collected from Market for wound, infection, operation and the full nutrition formula food of other stress situations patient lack again
It is few.Traditional Chinese medicine ingredients, or addition prebiotics are added on the basis of focusing on nutrition or in conjunction with Traditional Chinese medical theory in existing product
And probiotics.But not yet occur correcting wound, infection, operation and other stress situation patient's body negative nitrogen balances correlations in the market
Full nutrition formula food.
Summary of the invention
In view of the deficiencies of the prior art, the present invention is by providing a kind of full nutrition special medicine purposes for trauma patient
Formula food the technical issues of to solve wound, infection, operation and other stress situation patient's body negative nitrogen balances, and improves
The symptoms such as its endotrophic malabsorption.
To achieve the above object, the technical solution of the present invention is as follows:
A kind of full nutrition special medicine purposes formula food for trauma patient, by each group of following mass percent
It is grouped as: ocean Isin glue collagen peptide 6-7%, gadus albumen oligopeptide 6-7%, lactalbumin 8-10%, plant oil powder 12-
13%, maltodextrin 29-30%, isomalt 23-25%, dietary fiber 5-6%, minerals 2.2-2.22%, dimension life
Plain 0.098-0.103%, moisture 3-4%.
Preferably, the ocean Isin glue collagen peptide is the oligopeptide that molecular weight is less than 1000Da.
Preferably, the gadus albumen oligopeptide is the oligopeptide that molecular weight is less than 1000Da.
Further, the mass ratio of the ocean Isin glue collagen peptide and gadus albumen oligopeptide is 1:1.
Preferably, the plant oil powder is by one of corn oil, olive oil, linseed oil or a variety of auxiliary with food
Expect formulated, emulsification, sterilization, be spray-dried and manufactured powder.
Preferably, the dietary fiber be xylo-oligosaccharide, it is inulin, oligoisomaltose, one or more in oligofructose
Mixture.
Preferably, the minerals are the organic or inorganic compound of the minerals.
Preferably, in full nutrition special medicine purposes formula food described in every 100g, the minerals include: sodium 375-
380mg, potassium 500-510mg, copper 600-650 μ g, magnesium 80-85mg, iron 6-6.2mg, zinc 5.5-6mg, manganese 1400-1500 μ g, calcium
380-400mg, phosphorus 260-280mg, iodine 60-64 μ g, chlorine 550-600mg, selenium 25-27 μ g, molybdenum 25-30 μ g, chromium 20-22 μ g.
Preferably, in full nutrition special medicine purposes formula food described in every 100g, the vitamin includes: vitamin
A 400-450 μ g, vitamin D 6-6.5 μ g, vitamin E 6-7mg, vitamin K 27-29 μ g, vitamin B1 0.7-0.9mg、
Vitamin B207-0.9mg, vitamin B60.7-0.9mg, vitamin B121.1-1.35 μ g, niacin 4.1-4.5mg, folic acid
130-140 μ g, pantothenic acid 4-5mg, vitamin C 80-85mg, biotin 14-15 μ g.
Compared with prior art, advantages of the present invention:
(1) present invention can be directly absorbed using ocean Isin glue collagen peptide, gadus albumen oligopeptide as nitrogen source matrix
It utilizes；The medical usage formula food prepared through the invention can satisfy the normal nutrition demand of general trauma patient, not add
Add any medication active constituent, generation meal, correction wound, operation, infection and the negative nitrogen of stress situation patient's body can put down completely
Weighing apparatus and nutrient malabsorption.
(2) the invention using two kinds of oceans source oligopeptide as raw material, and ocean Isin glue collagen peptide and gadus egg
White oligopeptide mass ratio is 1:1, and sufficient protein provision is provided for patient；And by test of many times studies have shown that ocean
Oligopeptide bioavilability with higher in source can be absorbed by patient's rapid digestion.The collagen peptide in processes of wound repair
Predominantly collagenous fibres synthesis, wound closure provide nutritional substrate；In addition, gadus albumen oligopeptide is a kind of high-quality protein, it must
Palpus chemistry of amino acids scoring is higher, can meet the amino acid requirement of human body.Therefore, the present invention improves protein and energizes ratio, has
Conducive to patient's body negative nitrogen balance is improved, promote wound healing.
(3) present invention selects xylo-oligosaccharide and inulin as the main source of dietary fiber.The xylo-oligosaccharide property of can choose
Ground promotes the proliferation activity of intestinal bifidobacteria, and bifidobacterium factor functional is 10-20 times of other polymerization carbohydrates, has enhancing machine
Body immunity blood pressure lowering, reduces serum cholesterol, prevents the functions such as constipation；Currently, inulin has been widely used for person in middle and old age's milk
Powder, beverage, is a kind of very ideal dietary fibre materials in herbal tea at milk tablet.
The present invention is using ocean Isin glue collagen peptide, gadus albumen oligopeptide as matrix as a result, creatively as nitrogen
The nutritional ingredient in source, research and development for wound, infection, operation and other stress situations special medicine purposes formula food, will be from
The negative nitrogen balance for fundamentally correcting patient's body, improves the symptoms such as nutrient absorption is bad, while will greatly improve to marine resources
Utilization rate, have important Social benefit and economic benefit.
Detailed description of the invention
Present invention will be further explained below with reference to the attached drawings and examples.
Fig. 1 is the influence of model group and sample sets to rat back wound healing rate in embodiment 4；
Fig. 2 is that model group and sample sets rat back wound HE coloration result compare in embodiment 4；
Fig. 3 is the influence of model group and sample sets to rat back wound hydroxyl Proline content in embodiment 4.
Specific embodiment
The present invention is directed to unbalance for negative nitrogen in trauma patient body and the symptoms such as nutrient absorption is bad provide a kind of easily absorption
And nitrogen level in trauma patient body can be effectively adjusted, correct the specific full nutrition special medicine purposes formula of negative nitrogen balance after wound
Food.To achieve the above objectives, the present invention is with ocean collagen peptide, gadus albumen oligopeptide and high-quality protein source lactalbumin
Matrix, the nutrients such as addition carbohydrate, fat, minerals, vitamin, preparation obtain one kind and are suitable for wound, operation, infect and answer
Swash the special medicine purposes formula food of status patients.
A kind of full nutrition special medicine purposes formula food for trauma patient comprising each group of following parts by weight
Point: Isin glue collagen peptide 6-7 parts of ocean, 6-7 parts of gadus albumen oligopeptide, 8-10 parts of lactalbumin, plant oil powder 12-13
Part, 29-30 parts of maltodextrin, 23-25 parts of isomalt, 5-6 parts of dietary fiber, 2.2-2.22 parts of minerals, vitamin
0.098-0.103 parts, 3-4 parts of moisture.
Wherein, the ocean Isin glue collagen peptide is the oligopeptide that molecular weight is less than 1000Da；The gadus albumen is oligomeric
Peptide is the oligopeptide that molecular weight is less than 1000Da；The mass ratio of the ocean Isin glue collagen peptide and gadus albumen oligopeptide is 1:
1.The plant oil powder is by one of corn oil, olive oil, linseed oil or a variety of formulated, newborn with food auxiliary material
Change, sterilization, be spray-dried and manufactured powder.The dietary fiber is xylo-oligosaccharide, inulin, oligoisomaltose, oligomeric fruit
One or more mixtures of sugar.The minerals are the organic or inorganic compound of the minerals.
The present invention is described in further detail with attached drawing With reference to embodiment.
Embodiment 1
A kind of full nutrition special medicine purposes formula food for trauma patient, specific full nutrient formulation food described in 100g
Contain in product:
Ocean collagen peptide 6g, gadus albumen oligopeptide 6g, lactalbumin 10g, plant oil powder 12g, maltodextrin
30g, isomalt 25g, dietary fiber 6g, minerals 2.22g, vitamin 98.8mg, moisture 3g.
The additive amount of minerals is executed referring to " special medicine purposes formula food general rule ", wherein every 100g medical usage
The additive amount of formula food finished product mineral are as follows: sodium 375mg, potassium 510mg, 600 μ g of copper, magnesium 85mg, iron 6.2mg, zinc 6mg,
1400 μ g of manganese, calcium 380mg, phosphorus 260mg, 60 μ g of iodine, chlorine 600mg, 27 μ g of selenium, 30 μ g of molybdenum, 20 μ g of chromium.
The additive amount of vitamin is executed referring to " special medicine purposes formula food general rule ", wherein every 100g medical usage
The additive amount of vitamin in formula food finished product are as follows: 450 μ g of vitamin A, 6.5 μ g of vitamin D, vitamin E 6mg, vitamin
29 μ g of K, vitamin B10.9mg, vitamin B20.9mg, vitamin B60.9mg, vitamin B121.35 μ g, niacin 4.5mg,
140 μ g of folic acid, pantothenic acid 5mg, vitamin C 80mg, 14 μ g of biotin.
This formula food is as full nutritional support or part nutritional supplementation.The daily recommended intake 400g/60kg of patient is used
Warm water is modulated into paste (formula: water=1:3) and takes in afterwards.It can be taken by breakfast, lunch and dinner.If patient can normal diet, formula food make
For part nutritional supplementation, intake can be suitably reduced.
Embodiment 2
A kind of full nutrition special medicine purposes formula food for trauma patient, specific full nutrient formulation food described in 100g
Contain in product:
Ocean collagen peptide 7g, gadus albumen oligopeptide 7g, lactalbumin 8g, plant oil powder 13g, maltodextrin 29g,
Isomalt 25g, dietary fiber 5g, minerals 2.2g, vitamin 102.8mg, moisture 4g.
The additive amount of minerals is executed referring to " special medicine purposes formula food general rule ", wherein every 100g medical usage
The additive amount of formula food finished product mineral are as follows: sodium 380mg, potassium 500mg, 650 μ g of copper, magnesium 80mg, iron 6mg, zinc 5.5mg,
1500 μ g of manganese, calcium 400mg, phosphorus 280mg, 64 μ g of iodine, chlorine 550mg, 27 μ g of selenium, 25 μ g of molybdenum, 22 μ g of chromium.
The additive amount of vitamin is executed referring to " special medicine purposes formula food general rule ", wherein every 100g medical usage
The additive amount of vitamin in formula food finished product are as follows: 400 μ g of vitamin A, 6 μ g of vitamin D, vitamin E 7mg, vitamin K
27 μ g, vitamin B10.7mg, vitamin B20.7mg, vitamin B60.7mg, vitamin B121.1 μ g, niacin 4.1mg, leaf
130 μ g of acid, pantothenic acid 4mg, vitamin C 85mg, 15 μ g of biotin.
This formula food is as full nutritional support or part nutritional supplementation.The daily recommended intake 400g/60kg of patient is used
Warm water is modulated into paste (formula: water=1:3) and takes in afterwards.It can be taken by breakfast, lunch and dinner.If patient can normal diet, formula food make
For part nutritional supplementation, intake can be suitably reduced.
Embodiment 3
Safety evaluatio:
One, acute toxicity test
The special medicine purposes formula food that the present invention obtains, toxicity very little can not measure LD 50, and therefore, this test is adopted
With maximum tolerated dose (MTD) method.
1, experimental material
Cleaning grade kunming mice 20, half male and half female, weight 20-25g.Tested material is the special of the acquisition of case study on implementation 1 and 2
Medical usage formula food.
2, experimental method and result
(1) preliminary result is shown, formula food is modulated into paste with warm water, mouse maximal tolerance dose is 150g/kg.
(2) 2 groups are randomly divided by weight, stop feeding and drinking-water before stomach-filling 1h for the first time, eaten with the formula of 150g/kgbw
Product carry out stomach-filling, and continuous observation 14d continues observation 7 days.
In (3) 7 days, mouse does not occur death, and mouse feed is normal, full of vitality, and hair color light is without loose, without frightened
It faints.
Two, Genetic toxicity
1, experimental method
Micronucleus test: 50 mouse, weight 20-25g, half male and half female are randomly divided into 5 by gender and weight
Group.Negative control group gives physiological saline；3 dosage groups give special medicine purposes formula food, and dosage is respectively 100g/
Kgbw, 50g/kgbw and 15g/kgbw.Positive controls give cyclophosphamide, dosage 40mg/kgbw.After stomach-filling
6h takes breastbone to prepare bone marrow smear, Giemsa dyeing.Every animal observes 1 000 polychromatic erythrocytes, and record has micronucleus
Polychromatic erythrocyte number calculates microkernel incidence.
2, experimental result
Table 1: each group of other micronuclear rates.
Note: compared with negative control group, * P < 0.05, * * P < 0.01.
As shown in Table 1, compared with negative control group, the detection of positive controls (cyclophosphamide) micronuclear rates is significantly raised, together
When there are extremely significant difference (P < 0.01), illustrate modeling success.The equal < 4 ‰ of the micronuclear rates of three formula food dosage groups, and with
Significant difference (P > 0.05) is not present compared to all in negative control group.The result shows that special medicine purposes formula food is in each dosage
Under the conditions of have no mutagenesis.
Embodiment 4
Both effectiveness experiment:
One, excision property wound model
Rat eats influence of the inventive formulation food to wound healing rate.
1, modeling and grouping:
Healthy SD male rat 48 are chosen, weight 180-200g is randomly divided into two groups.Model control group and formulation samples
Group.Wound is cut off in the round full thickness skin of 48 rat back manufacture diameter 1cm long.Sample sets are given in 40g/kg example 1
Formula food.Model control group gives the physiological saline of equal volume.Respectively at 4 days, 8 days, 8 rats of execution in 12 days were obtained
Back wound tissue carries out wound healing rate, HE dyeing, the measurement of hydroxyl Proline content.
2, result and discussion
It can be seen from Fig. 1-3 compared with model group, the wound healing rate of formulation samples group, HE is dyed, and hydroxyl proline contains
Measuring measurement result has extremely significant sex differernce (P < 0.05).Display inventive formulation food is remarkably improved wound healing rate.
There is meaning of crucial importance for the nutritional support of trauma operation patient.
From the foregoing, it will be observed that the present invention is using ocean Isin glue collagen peptide, gadus albumen oligopeptide as nitrogen source matrix, ocean source is low
Poly- peptide bioavilability with higher, can be absorbed by patient's rapid digestion, and amino acid ratio meets the necessary amino acid of human body
Demand.According to the requirement of " special medicine purposes formula food general rule " and the nutritional need of wound, patient with operation, addition is suitable
Complete protein, carbohydrate, dietary fiber, multi-vitamins, the composite mineral matter of ratio.What is prepared through the invention is complete
Nutrition special medicine purposes formula food can satisfy the normal nutrition demand of general trauma patient, not add any medication
Active constituent generation meal, correction wound, operation, infection and stress situation patient's body negative nitrogen balance and nutriment can be taken the photograph completely
It takes and malabsorption.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention are fallen within the scope of the claimed invention.
Claims (9)
1. a kind of full nutrition special medicine purposes formula food for trauma patient, which is characterized in that by following quality percentage
The each group of ratio is grouped as: ocean Isin glue collagen peptide 6-7%, gadus albumen oligopeptide 6-7%, lactalbumin 8-10%, plant
Oil powder 12-13%, maltodextrin 29-30%, isomalt 23-25%, dietary fiber 5-6%, minerals 2.2-
2.22%, vitamin 0.098-0.103%, moisture 3-4%.
2. the full nutrition special medicine purposes formula food according to claim 1 for trauma patient, it is characterised in that:
The ocean Isin glue collagen peptide is the oligopeptide that molecular weight is less than 1000Da.
3. the full nutrition special medicine purposes formula food according to claim 1 for trauma patient, it is characterised in that:
The gadus albumen oligopeptide is the oligopeptide that molecular weight is less than 1000Da.
4. the full nutrition special medicine purposes formula food according to claim 2 or 3 for trauma patient, feature exist
In: the mass ratio of the ocean Isin glue collagen peptide and gadus albumen oligopeptide is 1:1.
5. the full nutrition special medicine purposes formula food according to claim 1 for trauma patient, it is characterised in that:
The plant oil powder be by one of corn oil, olive oil, linseed oil or a variety of formulated with food auxiliary material, emulsifications,
Sterilization is spray-dried and manufactured powder.
6. the full nutrition special medicine purposes formula food according to claim 1 for trauma patient, it is characterised in that:
The dietary fiber is xylo-oligosaccharide, inulin, oligoisomaltose, mixture one or more in oligofructose.
7. the full nutrition special medicine purposes formula food according to claim 1 for trauma patient, it is characterised in that:
The minerals are the organic or inorganic compound of the minerals.
8. the full nutrition special medicine purposes formula food according to claim 7 for trauma patient, it is characterised in that:
In full nutrition special medicine purposes formula food described in every 100g, the minerals include: sodium 375-380mg, potassium 500-
510mg, copper 600-650 μ g, magnesium 80-85mg, iron 6-6.2mg, zinc 5.5-6mg, manganese 1400-1500 μ g, calcium 380-400mg, phosphorus
260-280mg, iodine 60-64 μ g, chlorine 550-600mg, selenium 25-27 μ g, molybdenum 25-30 μ g, chromium 20-22 μ g.
9. the full nutrition special medicine purposes formula food according to claim 1 for trauma patient, it is characterised in that:
In full nutrition special medicine purposes formula food described in every 100g, the vitamin includes: vitamin A 400-450 μ g, dimension
Raw element D 6-6.5 μ g, vitamin E 6-7mg, vitamin K 27-29 μ g, vitamin B10.7-0.9mg, vitamin B2 07-
0.9mg, vitamin B60.7-0.9mg, vitamin B121.1-1.35 μ g, niacin 4.1-4.5mg, folic acid 130-140 μ g, pantothenic acid
4-5mg, vitamin C 80-85mg, biotin 14-15 μ g.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210844989.9A CN115997920A (en) | 2018-08-27 | 2018-08-27 | Total nutrient medical use formula food for wounded patients |
| CN201810983346.6A CN109247585A (en) | 2018-08-27 | 2018-08-27 | A kind of full nutrition special medicine purposes formula food for trauma patient |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810983346.6A CN109247585A (en) | 2018-08-27 | 2018-08-27 | A kind of full nutrition special medicine purposes formula food for trauma patient |
Related Child Applications (1)
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109717475A (en) * | 2019-01-28 | 2019-05-07 | 山东省科学院生物研究所 | A kind of special medicine purposes formula food containing marine organisms rouge |
| CN110916195A (en) * | 2019-11-25 | 2020-03-27 | 中国海洋大学 | Total nutrient tumor formula food added with specific marine oligopeptide and preparation method thereof |
| CN115053958A (en) * | 2022-07-05 | 2022-09-16 | 三奇生物医药(山东)有限公司 | Special meal food for postoperative patients and preparation method thereof |
| CN115812880A (en) * | 2022-12-16 | 2023-03-21 | 青岛中大寰球生物科技有限公司 | Perch protein peptide compound beverage |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105982331A (en) * | 2016-05-13 | 2016-10-05 | 浙江省海洋开发研究院 | Universal type aquatic collagen peptide food for wound healing |
| CN106578093A (en) * | 2016-12-23 | 2017-04-26 | 上海奥医生物医药科技有限公司 | Wound, infection, operation and other stress state special-purpose clinical nutrition formula and preparation method thereof |
| CN106579345A (en) * | 2016-12-21 | 2017-04-26 | 青岛琛蓝海洋生物工程有限公司 | Total nutrient formula containing marine active substances for FSMP (foods for special medical purpose) and preparation method of total nutrient formula |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104171798A (en) * | 2014-07-29 | 2014-12-03 | 胡安然 | Full-nutrition formula food suitable for patients with trauma, infection, operation and other stress states |
| CN104855960A (en) * | 2015-04-22 | 2015-08-26 | 劲膳美生物科技股份有限公司 | Non-complete nutrition formula food for wound infection following surgery and other emergency conditions |
| CN106136234A (en) * | 2016-07-02 | 2016-11-23 | 威海御膳坊生物科技有限公司 | A kind of postoperative patient special medicine purposes formula food |
| CN107822116A (en) * | 2017-11-13 | 2018-03-23 | 福建省水产研究所（福建水产病害防治中心） | Suitable for the ocean short peptide type special medicine purposes formula food of diabetic |
-
2018
- 2018-08-27 CN CN202210844989.9A patent/CN115997920A/en active Pending
- 2018-08-27 CN CN201810983346.6A patent/CN109247585A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105982331A (en) * | 2016-05-13 | 2016-10-05 | 浙江省海洋开发研究院 | Universal type aquatic collagen peptide food for wound healing |
| CN106579345A (en) * | 2016-12-21 | 2017-04-26 | 青岛琛蓝海洋生物工程有限公司 | Total nutrient formula containing marine active substances for FSMP (foods for special medical purpose) and preparation method of total nutrient formula |
| CN106578093A (en) * | 2016-12-23 | 2017-04-26 | 上海奥医生物医药科技有限公司 | Wound, infection, operation and other stress state special-purpose clinical nutrition formula and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 姜锡瑞: "《生物发酵产业技术》", 31 May 2016, 中国轻工业出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109717475A (en) * | 2019-01-28 | 2019-05-07 | 山东省科学院生物研究所 | A kind of special medicine purposes formula food containing marine organisms rouge |
| CN110916195A (en) * | 2019-11-25 | 2020-03-27 | 中国海洋大学 | Total nutrient tumor formula food added with specific marine oligopeptide and preparation method thereof |
| CN115053958A (en) * | 2022-07-05 | 2022-09-16 | 三奇生物医药(山东)有限公司 | Special meal food for postoperative patients and preparation method thereof |
| CN115812880A (en) * | 2022-12-16 | 2023-03-21 | 青岛中大寰球生物科技有限公司 | Perch protein peptide compound beverage |
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| Publication number | Publication date |
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| CN115997920A (en) | 2023-04-25 |
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Application publication date: 20190122 |