CN105410941A - Serene Tablet health-care food capable of increasing bone density and strengthening immunity and preparation method thereof - Google Patents
Serene Tablet health-care food capable of increasing bone density and strengthening immunity and preparation method thereof Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses Serene Tablet health-care food capable of increasing bone density and strengthening immunity and a preparation method thereof. The Serene Tablet health-care food is prepared from the following raw materials with homology of medicine and food: pearl powder, calcium carbonate, D-Glucosamine hydrochloride, casein phosphopeptides, starch, dextrin and magnesium stearate and by the following steps of sieving, weighing, mixing, preparing of a soft material, pelletizing, drying, granulating, total blending, tableting, inner packing, outer packing, inspection and storage to obtain tablets. The characteristic ingredients and content are described as follows: every 100g of tablet contains 14.5g of calcium and 15.5g of D-Glucosamine hydrochloride; and the Serene Tablet health-care food has the health-care functions of increasing bone density and strengthening immunity. The emphasis of the product is put on disease treatment above disease prevention, under the condition that the disease prevention lies in improving the concept of health of immunity to guide the development tendency, the invention provides the double-function health-care food which can not only increase bone density and relieve osteoarthritis symptom, but also strengthen human immunity, and the health-care food is suitable for middle-aged and aged people or people with low immunity to eat.
Description
Technical field
The present invention relates to a kind of auspicious right sheet health food of Dongting Lake board and the method for making thereof that can increase human bone mineral density and immunity, belong to technical field of health care food.
Background technology
Osteoarthritis is a kind of DD, the incidence of disease is very high, often send out after middle age, in more than 50 years old crowds, 50% suffers from Osteoarthritis, in over-65s crowd, the women of 90% and the male sex of 80% suffer from osteoarthritis, along with the increase of China's aging, middle-aged and old arthritic sharply increases, and the illness rate of osteoarthritis is higher than European and American developed countries far away;
1956, first Sweden researcher found that aminoglucose hydrochloride may work to the osteoarthritis cause of disease.Afterwards, through research and the clinical testing of various countries scientist decades, Glucosamine is widely applied as the first-selected etiological treatment medicine for the treatment of osteoarthritis." Chinese medical converges and removes from office " book is also pointed out: " at present, in worldwide, Glucosamine, as the most directly renovation agent of articular cartilage, is thought by medical circle the specific drug can giving treatment to osteoarthrosis;
On international market, glucosamine product has more than 200 to plant, and can be divided into two classes substantially: one is the glucosamine formulations adding chemical antiphlogistic; Two is numerous aminoglucose carbohydrate health foods.Along with the raising of consumer health's consciousness, aminoglucose carbohydrate health food progressively occupies consumption market, and on market, Glucosamine health food can be divided into 3 classes again: one is simple Glucosamine component preparation; Two is compound formulations of Glucosamine+chondroitin sulfate; Three is Glucosamine+other compound products becoming to be grouped into;
Along with the bad reaction of the disorder of the increase of being growing more intense of social competition, live and work pressure, work and rest rule, spirit too anxiety, antibiotic abuse, some drugs all can cause human body immunity of organisms low, particularly suffer from some chronic diseases as suffered from the elderly of osteoarthritis, the ability resisting outer heresy is very low, weather slight change, the various diseases such as flu come one after another, and the health of body in serious threat.
The first loyalty of research and development of products of the present invention is exactly increase based on aging society the elderly osteoarthritis incidence of disease, body immune function is caused sharply to decline, and the aminoglucose carbohydrate health food in the market with good treatment osteoarthritis is more with the compound formulation product of simple Glucosamine component preparation and Glucosamine+chondroitin sulfate, Glucosamine+other compound products becoming to be grouped into are less, particularly increase bone density, two effect products of develop immunitypty, market does not almost have, therefore, diseases prevention is overweighted from curing the disease, under diseases prevention is that the health theory of raising resistance guides development trend situation, one is provided both to increase human bone mineral density, alleviate osteoarthritis symptoms, strengthen again the multifunctional health-care food of body immunity, this disappearance can well be filled up, meet the need of market.
Summary of the invention
For solving the problem of current middle-aged and old ubiquity osteoporosis and hypoimmunity, the object of this invention is to provide a kind of auspicious right sheet health food of Dongting Lake board that can increase human bone mineral density and immunity, in order to meet numerous the elderly to having the demand increasing bone density and the bifunctional health food of develop immunitypty, improve middle-aged and old health status.Another object of the present invention is to provide the preparation method of the auspicious right sheet health food of Dongting Lake board.
For solving its technical problem, the technical solution used in the present invention is: the present inventor is according to middle-aged and old rule of life and physiological feature, from market to the demand of the healthy nonhazardous health product of two effect, research composition is natural emphatically, efficacy effect is strong, good absorbing effect, the prescription played a role can be worked in coordination with after each components compatibility, through screening layer by layer, finally develop a kind of auspicious right sheet health food of Dongting Lake board that can increase human bone mineral density and immunity, this health food is made up of the raw material of following integration of drinking and medicinal herbs: wherein primary raw material is: pearl powder, calcium carbonate, D-Glucosamine Hydrochloride, auxiliary material is: CPP, starch, dextrin and dolomol, through processing the tablet be prepared from, its significant composition and content are: every 100g contains: calcium 14.5g, D-Glucosamine Hydrochloride 15.5g, product specification is: 0.75g/ sheet, its health care is: increase bone density, develop immunitypty, suitable population is the elderly or immunocompromised person.
The raw material of the auspicious right sheet health food of this Dongting Lake board select pearl powder be because: pearl is sweet, salty, cold, various trace elements and more than the 17 kinds amino acid needed by human body such as the calcium containing needed by human body, magnesium, iron, have antifatigue, improve the effect such as immunity of organisms, prevention of osteoporosis;
Calcium carbonate is selected to be because its main component is calcium, calcium is the indispensable trace element of human body, be the constructor of health, again the attemperator of health, people in old period can draw various " calcium deficiency " syndrome, a series of illnesss such as such as osteoporosis, osteoproliferation, hypertension along with migrating of calcium;
D-Glucosamine Hydrochloride is selected to be commonly called as ammonia sugar, because one of the important component part and the important nutrient forming cartilage cell of its proteoglycan that to be hydrophily extremely strong, ammonia sugar can not only collagen in synthesized human, repairs damaged cartilage, can also block the pathologic process of Osteoarthritis, improve joint motion, alleviating pain, prevents PD, is a kind of medicine for the treatment of Osteoarthritis, determined curative effect, bad reaction is few;
Therefore, the auspicious right sheet function of health food of this Dongting Lake board is made good use of, and has no side effect, play integrally-regulated advantage, with the most direct effective method of Orally taken product, allow numerous the elderly increase bone density and develop immunitypty unconsciously, reach the object of good health and a long life.The various experiments such as the Safety and toxicology experiment of product of the present invention through disease prevention and control center of Hunan Province, the zoopery of increase bone substance density improving function, develop immunitypty functional experiment, functional component, stability test, Hygienic determination, result confirms that board auspicious right sheet in Dongting Lake belongs to nontoxic level and has the high-quality health care product increasing bone density, the two effect of develop immunitypty.
The consumption of health food of the present invention is that the present inventor is with reference to a large amount of scientific literature, Multiple experiments prepares final summary repeatedly, the raw material dosage of each component has good effect within the scope of following weight portion: pearl powder 2 ~ 5 parts, 30 ~ 40 parts, calcium carbonate, D-acidic group glucosamine salt hydrochlorate 10 ~ 20 parts, CPP 1 ~ 3 part, starch 25 ~ 30 parts, 12 ~ 18 parts, dextrin, dolomol 1 ~ 2 part.
The preferred composition of raw materials of the auspicious right sheet health food of described Dongting Lake board is following weight portion: pearl powder 2 parts, 35 parts, calcium carbonate, D-acidic group glucosamine salt hydrochlorate 16 parts, CPP 1 part, starch 28 parts, 14 parts, dextrin and dolomol 1 part.
The preparation method of the auspicious right sheet health food of described Dongting Lake board, the method comprises the step of following order: sieve, weigh, mix, softwood processed, granulation, drying, whole grain, total mixed, compressing tablet, inner packing, external packing, inspection put in storage, be finally prepared from tablet.
Compared with prior art, the present invention has following substantive distinguishing features:
1, product of the present invention has develop immunitypty and increases two efficacy effects of bone density, and health-care effect two obtains at one stroke;
2, the technology of the present invention content sources key technology in the national OTC of the certificate that gets the Green Light, formula is advanced, mature technology can operate;
3, the present invention's formula is compound formula, and in major ingredient, pearl powder, D-Glucosaminic acid salt are medicine-food two-purpose material, and composition is natural, good absorbing effect, have no Reporting of harms between raw material;
The various experiments such as 4, the Safety and toxicology experiment of product of the present invention through disease prevention and control center of Hunan Province, the zoopery of increase bone substance density improving function, develop immunitypty functional experiment, functional component, stability test, Hygienic determination, result shows, this product belongs to nontoxic level and has the high-quality health care product increasing bone density, the two effect of develop immunitypty;
5, product of the present invention is health food, raw material is extensive, method for making is simple, taking convenience, easy to utilize.
Compared with prior art, the present invention has following progress significantly:
1, the present invention compensate in market the disappearance of two effect products increasing bone density, develop immunitypty, meets the need of market;
2, the present invention takes the lead in employing pearl powder, calcium carbonate and D-Glucosaminic acid salt is the prescription of primary raw material;
3, salt acid type Glucosamine selected by raw material of the present invention, purity is higher, sodium, potassium content are few compared with sulfuric acid type Glucosamine, with the addition of pearl powder in formula simultaneously, its calcium form exists with free state, trap is better, and not easily remain in internal organs, the compound product that several material combination is produced decreases the negative interaction of human body to sodium, potassium, calcium composition excessive consumption as far as possible when efficacy effect reaches completely;
4, the technology of the present invention content sources key technology in the national OTC of the certificate that gets the Green Light;
5, this invention simplifies preparation technology, be convenient to industrialization, automated production;
6, product of the present invention selects Tabules, provides convenience for the elderly goes out to carry, and simultaneously after product tabletted, can increase stability and extend validity.
Detailed description of the invention
(1) be further described below in conjunction with the beneficial effect of experimental example to the auspicious right sheet health food of this Dongting Lake board:
Experiment material is the auspicious right sheet health food of Dongting Lake board, and its significant composition and content are: every 100g contains: calcium 14.5g, D-Glucosamine Hydrochloride 15.5g; Product specification is: 0.75g/ sheet.
Embodiment 1: the toxicological experiment of the preferred composition of raw materials of the auspicious right sheet health food of Dongting Lake board:
Disease prevention and control center of Hunan Province carries out toxicological experiment to the auspicious right flake products of the Dongting Lake board produced by optimization formula, it is one large group with every 40 mouse, totally five large groups, 0.375g/Kg.bw, 0.750g/Kg.bw, 2.250g/Kg.bw dosage gavage is set, once a day, continuous 30 days, final inspection conclusion was as follows:
1, acute oral toxicity test: 20.00g/Kg.bw is greater than to the maximum tolerance agent (MTD) of Kunming kind male and female mouse, belongs to nontoxic level;
2, three genetic toxicity tests: Salmonella reversion test, mice bone marrow micronucleus, the test of mouse sperm shape are feminine gender;
3,30 days feeding trials: auspicious for Dongting Lake board right sheet is mixed feed hole rat feeding 30 days by the ratio with 1.875%, 3.740%, 7.500%, experimental session, animal growth is good, each dosage group body weight, weightening finish, food utilization, routine blood indexes, blood biochemistry index, organ weights and internal organs/body weight ratio compare with control group, there was no significant difference (P>0.05).Gross anatomy and tissue pathology checking have no obviously relevant with sample abnormal change.The auspicious right sheet of prompting Dongting Lake board is fed and is had no obvious toxic-side effects to rat for 30 days.
Embodiment 2: the increase bone density animal functional experiment of the preferred composition of raw materials of the auspicious right sheet health food of Dongting Lake board:
Disease prevention and control center of Hunan Province carries out increase bone density animal functional experiment to the auspicious right flake products of the Dongting Lake board produced by optimization formula, select the male rat 50 of body weight 60-80 gram, 0.375g/Kg.bw, 0.750g/Kg.bw, 2.250g/Kg.bw dosage gavage is set, once a day, compare with low calcium feed formula group, experiment in continuous 90 days, final inspection conclusion is as follows:
Show to the result of rat oral gavage after three months with the auspicious right sheet of the Dongting Lake board of 0.375g/Kg.bw, 0.750g/Kg.bw, 2.250g/Kg.bw dosage: the height value added at 2.250g/Kg.bw dosage group experiment end is significantly higher than low calcium control group (P>0.05); The bone density of 2.250g/Kg.bw dosage group rat femur center and distal end, femur calcium content and TC are significantly higher than low calcium control group (P<0.05 or P<0.01); 0.750g/Kg.bw, 2.250g/Kg.bw dosage group rat is taken in calcium, excrement calcium and urine calcium content and is significantly higher than low calcium control group (P<0.01); 0.750g/Kg.bw, 2.250g/Kg.bw dosage group calcium in rats apparent absorptivity and Retention are significantly lower than low calcium control group (P<0.01).Above indices and the corresponding calcium carbonate control group comparing difference of 2.250g/Kg.bw dosage experiments rat do not have conspicuousness (P>0.05); Prompting is under this experiment condition, and board auspicious right sheet in Dongting Lake has the effect increasing rat bone density.
Embodiment 3: the develop immunitypty functional experiment of the preferred composition of raw materials of the auspicious right sheet health food of Dongting Lake board:
Disease prevention and control center of Hunan Province carries out develop immunitypty animal functional experiment to the auspicious right flake products of the Dongting Lake board produced by optimization formula, with every 40 mouse in order to one large group, totally five large groups carry out immunity test experiments, 0.375g/Kg.bw, 0.750g/Kg.bw, 2.250g/Kg.bw dosage gavage is set, once a day, continuous 30 days, final inspection conclusion was as follows:
Under this experiment condition, per os gavage gives mouse 0.375g/Kg.bw, 0.750g/Kg.bw, the auspicious right sheet of Dongting Lake board of 2.250g/Kg.bw dosage 30 days, compare with control group, 0.750g/Kg.bw, 2.250g/Kg.bw dosage can significantly improve mouse delayed allergy ability, NK cytoactive, 2.250g/Kg.bw dosage can significantly improve mouse HD50 value, antibody-producting cell number (P<0.05 or P<0.01), each dosage increases Mouse Weight, thymus gland/body weight ratio, spleen/body weight ratio, lymphocyte transformation ability, the ability of carbonic clearance and macrophage phagocytic chicken red blood cell does not all make significant difference (P>0.05).The auspicious right sheet of prompting Dongting Lake board has develop immunitypty function.
(2) below by embodiment, preparation method of the present invention is further illustrated:
One, first the carrying out of the raw material of the auspicious right sheet health food of Dongting Lake board is screened:
Board auspicious right sheet health food in Dongting Lake selects to have the raw material increasing bone density and develop immunitypty function: primary raw material is: pearl powder, calcium carbonate and D-propylhomoserin glucosamine salt hydrochlorate, and all the other are auxiliary material, and auxiliary material is the product meeting and require in pharmacopeia for 2015.The nature,taste and action of primary raw material is as follows:
(1) pearl powder: pearl is sweet, salty, cold.The thoughts of returning home, Liver Channel.Have arresting convulsion of calming the nerves, improving eyesight disappears screen, detoxify and promote granulation, moistening skin and eliminating spot.For insomnia of palpitating with fear, infantile convulsion epilepsy, cataract, the diseases such as sore is not held back, skin splash.Research in recent years confirms again the various trace elements such as calcium, magnesium, iron containing needed by human body in pearl, particularly containing the rare element such as germanium, vanadium; Separately to there are some researches show in pearl containing more than 17 kinds amino acid needed by human body and other active ingredient, there is antifatigue, improve body low resistance, anti-inflammatory, anti-ageing, promote longevity, the effect such as antitumor, prevention of osteoporosis.Every consumption per day 0.1 ~ 0.3g of Pharmacopoeia of the People's Republic of China version recommendation pearl in 2015, the every consumption per day of this product pearl powder is 0.09g, and consumption is safe and effective;
(2) calcium carbonate: calcium is one of mineral matter of needed by human is also the mineral element that in human body, content is maximum.Show according to the study: when people exceedes 50 years old, bone total amount reduces 30%, during people to 60 year old, the loss of bone total amount is more than 50%.So people to person in middle and old age period along with migrating of calcium in body can cause various " calcium deficiency " syndrome.Such as: climacteric metancholia, osteoporosis, osteoproliferation, hypertension, arrhythmia, diabetes, poor appetite, apathy, tired out, the pain in waist and lower extremities in the whole body, drowsiness, knot, a series of pathology such as numb in every limb, calculus, neurasthenia, health become short, angiocardiopathy, senile dementia, vascular sclerosis, cancer, therefore, old man needs to replenish the calcium.Be 250-1000mg according to vitamin, mineral matter consumption calcium recommended amounts every day, in this product calcium carbonate, the every consumption per day of calcium is 636mg, and consumption is safe and effective;
(3) D-Glucosamine Hydrochloride: Glucosamine is commonly called as ammonia sugar, have another name called gucosamine abroad, one of the important component part and the important nutrient forming cartilage cell of the extremely strong proteoglycan of hydrophily, also be the basis of cartilage matrix and joint fluid, be distributed widely in organization of human body tissue, as in cartilage, ligament and tendon; Ammonia sugar can not only collagen in synthesized human, repairs damaged cartilage; And can intense stimulus synovial cell regenerate, expedite the emergence of and supplementary knuckle synovia, continuous lubricating joint cartilage aspect, the effect of reducing friction, makes joint part nimbly and freely; Also control the metabolic balance of the osteoarticular health of human body and articular cartilage and synovial membrane.
two, right againthe production method of the auspicious right sheet health food of Dongting Lake board further illustrates:
Embodiment 1: the production method of the auspicious right sheet health food of Dongting Lake board comprises the steps:
1, get the raw materials ready, sieve, weigh: prepare pearl powder 2 parts, D-acidic group glucosamine salt hydrochlorate 16 parts, CPP 1 part, cross 60 mesh sieves respectively, for subsequent use; By 35 parts, calcium carbonate, starch 28 parts, 14 parts, dextrin, dolomol 1 part, crosses 60 mesh sieves respectively, for subsequent use;
2, mix: by pearl powder, CPP, D-acidic group glucosamine salt hydrochlorate after weighing, put three-dimensional motion mixer (SYH-300, Europe, Nanjing side machinery) middle mixing, obtain mixed powder A, mixed powder A and calcium carbonate, starch, dextrin are put into mixer (CH-200, Jiangyin Tongda Machineries) middle mixing 30min, obtain total mixed powder, for subsequent use;
3, softwood processed: with the ethanolic solution of 90%, add the obtained total mixed powder of step 2 and carry out stirrings and soften, hold agglomerating with have gentle hands, namely that pinches falls apart for spending, stand-by;
4, granulate: utilize efficient wet mixer-granulator (YR-160, Jiangyin Tongda Machineries), the material obtained by step 3, makes grain and crosses 16 mesh sieves, obtaining wet grain stand-by;
5, dry: step 4 to be obtained wet granulation and put into hot air circulation drying oven (CT-C-II, Wuxi China star medicine) inner drying, dry at temperature is 50 ~ 60 DEG C, make the water content < 5% of material particles, obtain dried particles;
6, whole grain: the dried particles obtained by step 5, crosses 14 mesh sieves, leaves particulate, coarse fodder is returned step 3, make softwood;
7, the total mixed particle of system: particulate material obtained in step 6 put in mixer (SYH-600, the positive drying equipment of Changzhou product), added 60 mesh sieves and the standby dolomol of institute after weighing, and carried out the abundant stirring of 10 minutes, obtain always mixed particle;
8, compressing tablet: the total mixed particle obtained through step 7 is put into compressing tablet in high speed tablet press (GZPL, traditional Chinese medicines dragon in Beijing is vertical), the heavy 0.75g/ sheet of sheet;
9, inner packing: adopt satisfactory PETG bottle to be packaging material, be wrapped inside dress;
10, external packing: finished product step 9 being installed bottle is put into packing case and carried out external packing, obtains finished product box stand-by;
11, check, put in storage: by product inspection warehousing after passing.
Embodiment 2: the production method of the auspicious right sheet health food of another Dongting Lake board comprises the steps:
1, get the raw materials ready, sieve, weigh: prepare pearl powder 4 parts, D-acidic group glucosamine salt hydrochlorate 20 parts, CPP 2 parts, cross 60 mesh sieves respectively, for subsequent use; By 30 parts, calcium carbonate, starch 25 parts, 12 parts, dextrin, dolomol 2 parts, crosses 60 mesh sieves respectively, for subsequent use;
2, mix: by pearl powder, CPP, D-acidic group glucosamine salt hydrochlorate after weighing, put three-dimensional motion mixer (SYH-300, Europe, Nanjing side machinery) middle mixing, obtain mixed powder A, mixed powder A and calcium carbonate, starch, dextrin are put into mixer (CH-200, Jiangyin Tongda Machineries) middle mixing 30min, obtain total mixed powder, for subsequent use;
3, softwood processed: with the ethanolic solution of 90%, add the obtained total mixed powder of step 2 and carry out stirrings and soften, hold agglomerating with have gentle hands, namely that pinches falls apart for spending, stand-by;
4, granulate: utilize efficient wet mixer-granulator (YR-160, Jiangyin Tongda Machineries), the material obtained by step 3, makes grain and crosses 16 mesh sieves, obtaining wet grain stand-by;
5, dry: step 4 to be obtained wet granulation and put into hot air circulation drying oven (CT-C-II, Wuxi China star medicine) inner drying, dry at temperature is 50 ~ 60 DEG C, make the water content < 5% of material particles, obtain dried particles;
6, whole grain: the dried particles obtained by step 5, crosses 14 mesh sieves, leaves particulate, coarse fodder is returned step 3, make softwood;
7, the total mixed particle of system: particulate material obtained in step 6 put in mixer (SYH-600, the positive drying equipment of Changzhou product), added 60 mesh sieves and the standby dolomol of institute after weighing, and carried out the abundant stirring of 10 minutes, obtain always mixed particle;
8, compressing tablet: the total mixed particle obtained through step 7 is put into compressing tablet in high speed tablet press (GZPL, traditional Chinese medicines dragon in Beijing is vertical), the heavy 0.75g/ sheet of sheet;
9, inner packing: adopt satisfactory PETG bottle to be packaging material, be wrapped inside dress;
10, external packing: finished product step 9 being installed bottle is put into packing case and carried out external packing, obtains finished product box stand-by;
11, check, put in storage: by product inspection warehousing after passing.
Embodiment 3: the production method of the auspicious right sheet health food of the third Dongting Lake board comprises the steps:
1, get the raw materials ready, sieve, weigh: prepare pearl powder 5 parts, D-acidic group glucosamine salt hydrochlorate 10 parts, CPP 3 parts, cross 60 mesh sieves respectively, for subsequent use; By 40 parts, calcium carbonate, starch 30 parts, 18 parts, dextrin, dolomol 1.5 parts, crosses 60 mesh sieves respectively, for subsequent use;
2, mix: by pearl powder, CPP, D-acidic group glucosamine salt hydrochlorate after weighing, put three-dimensional motion mixer (SYH-300, Europe, Nanjing side machinery) middle mixing, obtain mixed powder A, mixed powder A and calcium carbonate, starch, dextrin are put into mixer (CH-200, Jiangyin Tongda Machineries) middle mixing 30min, obtain total mixed powder, for subsequent use;
3, softwood processed: with the ethanolic solution of 90%, add the obtained total mixed powder of step 2 and carry out stirrings and soften, hold agglomerating with have gentle hands, namely that pinches falls apart for spending, stand-by;
4, granulate: utilize efficient wet mixer-granulator (YR-160, Jiangyin Tongda Machineries), the material obtained by step 3, makes grain and crosses 16 mesh sieves, obtaining wet grain stand-by;
5, dry: step 4 to be obtained wet granulation and put into hot air circulation drying oven (CT-C-II, Wuxi China star medicine) inner drying, dry at temperature is 50 ~ 60 DEG C, make the water content < 5% of material particles, obtain dried particles;
6, whole grain: the dried particles obtained by step 5, crosses 14 mesh sieves, leaves particulate, coarse fodder is returned step 3, make softwood;
7, the total mixed particle of system: particulate material obtained in step 6 put in mixer (SYH-600, the positive drying equipment of Changzhou product), added 60 mesh sieves and the standby dolomol of institute after weighing, and carried out the abundant stirring of 10 minutes, obtain always mixed particle;
8, compressing tablet: the total mixed particle obtained through step 7 is put into compressing tablet in high speed tablet press (GZPL, traditional Chinese medicines dragon in Beijing is vertical), the heavy 0.75g/ sheet of sheet;
9, inner packing: adopt satisfactory PETG bottle to be packaging material, be wrapped inside dress;
10, external packing: finished product step 9 being installed bottle is put into packing case and carried out external packing, obtains finished product box stand-by;
11, check, put in storage: by product inspection warehousing after passing.
three, rightthe product pilot scale demonstration test report of the auspicious right sheet health food of Dongting Lake board:
Satisfactory former, auxiliary material is carried out the production of 3 batches, 20101210 batches are amplified production by 40 times of formula ratios and (wherein before compressing tablet, take out 10kg, for toxicological study and animal function test), 20101211,20101212 expand 10 times, basic technological parameters is without large change, pilot product is used for the detection of functional component, stability test, and hygiene inspection and sample are rechecked;
Enlarged experiment result of the test is as following table:
According to the data display in scale up test scale-up sample, determine that the process stabilizing of this product is reliable, production technology is scientific and reasonable, and meet the requirement that health food is produced, can amplify production, indices conforms with the regulations.
Claims (7)
1. the auspicious right sheet health food of Dongting Lake board of an energy develop immunitypty and increase bone density, it is characterized in that: this health food is made up of the raw material of following integration of drinking and medicinal herbs: wherein primary raw material is: pearl powder, calcium carbonate, D-Glucosamine Hydrochloride, auxiliary material is: CPP, starch, dextrin and dolomol, through processing the tablet be prepared from, its significant composition and content are: every 100g contains: calcium 14.5g, D-Glucosamine Hydrochloride 15.5g; Product specification is: 0.75g/ sheet; Its health care is: increase bone density, develop immunitypty; Suitable population is the elderly or immunocompromised person.
2. according to claim 1 can develop immunitypty and increase the auspicious right sheet health food of Dongting Lake board of bone density, it is characterized in that: the weight portion of described each raw material dosage is as follows: pearl powder 2 ~ 5 parts, 30 ~ 40 parts, calcium carbonate, D-acidic group glucosamine salt hydrochlorate 10 ~ 20 parts, CPP 1 ~ 3 part, starch 25 ~ 30 parts, 12 ~ 18 parts, dextrin, dolomol 1 ~ 2 part.
3. energy develop immunitypty and the auspicious right sheet health food of Dongting Lake board increasing bone density according to claim 1 or 2, it is characterized in that: the preferred composition of raw materials of the auspicious right sheet health food of described Dongting Lake board is following weight portion: pearl powder 2 parts, 35 parts, calcium carbonate, D-acidic group glucosamine salt hydrochlorate 16 parts, CPP 1 part, starch 28 parts, 14 parts, dextrin and dolomol 1 part.
4. according to claim 1 can develop immunitypty and increase the auspicious right sheet health food of Dongting Lake board of bone density, it is characterized in that: the preferred composition of raw materials of the auspicious right sheet health food of described Dongting Lake board is following weight portion: pearl powder 4 parts, 30 parts, calcium carbonate, D-acidic group glucosamine salt hydrochlorate 20 parts, CPP 2 parts, starch 25 parts, 12 parts, dextrin and dolomol 2 parts.
5. according to claim 1 can develop immunitypty and increase the auspicious right sheet health food of Dongting Lake board of bone density, it is characterized in that: the preferred composition of raw materials of the auspicious right sheet health food of described Dongting Lake board is following weight portion: pearl powder 5 parts, 40 parts, calcium carbonate, D-acidic group glucosamine salt hydrochlorate 10 parts, CPP 3 parts, starch 30 parts, 18 parts, dextrin and dolomol 1.5 parts.
6. the preparation method of the auspicious right sheet health food of Dongting Lake board of an energy develop immunitypty and increase bone density, it is characterized in that: the method comprises the step of following order: sieve, weigh, mix, softwood processed, granulation, drying, whole grain, total mixed, compressing tablet, inner packing, external packing, inspection put in storage, be finally prepared from tablet.
7. according to claim 6 can develop immunitypty and increase the preparation method of the auspicious right sheet health food of Dongting Lake board of bone density, it is characterized in that: the method comprises the steps:
1, get the raw materials ready, sieve, weigh: prepare pearl powder 2 ~ 5 parts, 30 ~ 40 parts, calcium carbonate, D-acidic group glucosamine salt hydrochlorate 10 ~ 20 parts, CPP 1 ~ 3 part, starch 25 ~ 30 parts, 12 ~ 18 parts, dextrin, dolomol 1 ~ 2 part crosses 60 mesh sieves respectively, for subsequent use;
2, mix: by pearl powder, CPP, D-acidic group glucosamine salt hydrochlorate after weighing, put three-dimensional motion mixer (SYH-300, Europe, Nanjing side machinery) middle mixing, obtain mixed powder A, mixed powder A and calcium carbonate, starch, dextrin are put into mixer (CH-200, Jiangyin Tongda Machineries) middle mixing 30min, obtain total mixed powder, for subsequent use;
3, softwood processed: with the ethanolic solution of 90%, add the obtained total mixed powder of step 2 and carry out stirrings and soften, hold agglomerating with have gentle hands, namely that pinches falls apart for spending, stand-by;
4, granulate: utilize efficient wet mixer-granulator (YR-160, Jiangyin Tongda Machineries), the material obtained by step 3, makes grain and crosses 16 mesh sieves, obtaining wet grain stand-by;
5, dry: step 4 to be obtained wet granulation and put into hot air circulation drying oven (CT-C-II, Wuxi China star medicine) inner drying, dry at temperature is 50 ~ 60 DEG C, make the water content < 5% of material particles, obtain dried particles;
6, whole grain: the dried particles obtained by step 5, crosses 14 mesh sieves, leaves particulate, coarse fodder is returned step 3, make softwood;
7, the total mixed particle of system: particulate material obtained in step 6 put in mixer (SYH-600, the positive drying equipment of Changzhou product), added 60 mesh sieves and the standby dolomol of institute after weighing, and carried out the abundant stirring of 10 minutes, obtain always mixed particle;
8, compressing tablet: the total mixed particle obtained through step 7 is put into compressing tablet in high speed tablet press (GZPL, traditional Chinese medicines dragon in Beijing is vertical), the heavy 0.75g/ sheet of sheet;
9, inner packing: adopt satisfactory PETG bottle to be packaging material, be wrapped inside dress;
10, external packing: finished product step 9 being installed bottle is put into packing case and carried out external packing, obtains finished product box stand-by;
11, check, put in storage: by product inspection warehousing after passing.
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| CN114288349A (en) * | 2022-01-05 | 2022-04-08 | 盖茨汉普(武汉)植物应用研究有限公司 | MitoQ glucosamine soft capsule preparation formula and preparation process |
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| CN106165898A (en) * | 2016-07-12 | 2016-11-30 | 江苏神华药业有限公司 | There is health composition of increase bone density, easing joint movement and preparation method thereof |
| CN110897152A (en) * | 2019-11-22 | 2020-03-24 | 安徽萨普丽生物医药有限公司 | Composition and capsule for increasing bone mineral density and preparation method thereof |
| CN114288349A (en) * | 2022-01-05 | 2022-04-08 | 盖茨汉普(武汉)植物应用研究有限公司 | MitoQ glucosamine soft capsule preparation formula and preparation process |
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Address after: 415000 Changde city of Hunan province Wuling district north of the city community construction office Jian Min Xiang Road No. 348 Applicant after: Hunan Da Hu Biotechnology Co., Ltd. Applicant after: Dahu Aquaculture Co., Ltd. Address before: No. 348, Wuling District, Wuling District, Changde, Hunan Applicant before: HUNAN DONGTING WATER YIELD PEARL CO., LTD. Applicant before: Dahu Aquaculture Co., Ltd. |
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Application publication date: 20160323 |