CN106165898A - There is health composition of increase bone density, easing joint movement and preparation method thereof - Google Patents
There is health composition of increase bone density, easing joint movement and preparation method thereof Download PDFInfo
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- CN106165898A CN106165898A CN201610543959.9A CN201610543959A CN106165898A CN 106165898 A CN106165898 A CN 106165898A CN 201610543959 A CN201610543959 A CN 201610543959A CN 106165898 A CN106165898 A CN 106165898A
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- joint movement
- bone density
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention belongs to health product technology field, be specifically related to a kind of there is increase bone density, the health composition of easing joint movement and preparation method.This health composition is made up of following raw material: chondroitin sulfate, glucosamine, hyaluronic acid, Paecilomyces hepiali Chen et Dai Mycelia, the Cortex Eucommiae, Radix Cyathulae, Herba Epimedii, Rhizoma Smilacis Glabrae, Herba Dendrobii, Rhizoma Drynariae.Its manufacture method is as follows: by the Cortex Eucommiae, Radix Cyathulae, Herba Epimedii, Rhizoma Smilacis Glabrae, Herba Dendrobii, and Rhizoma Drynariae obtains extract powder through Hydrolysis kinetics, then with chondroitin sulfate, glucosamine, hyaluronic acid, Paecilomyces hepiali Chen et Dai Mycelia mixes.Ten kinds of medicines of the present invention complement each other, and invigorating the kidney and strengthening the bones is gone together with easing joint movement, and synergism plays the function preferably increasing bone density, easing joint movement.
Description
Technical field
The invention belongs to field of health care food, be specifically related to a kind of have increase bone density, the health-care combination of easing joint movement
Thing and preparation method thereof.
Background technology
Health food refers to claim have specific health care or the food for the purpose of vitimin supplement, mineral,
I.e. it is suitable for specific crowd to eat, there is regulation body function, not for the purpose for the treatment of disease, and human body is not produced any
Acute, the subacute or food of chronic hazard.
There is presently no the health composition that can safely, effectively increase bone density, easing joint movement.
Summary of the invention
The present invention provides a kind of health composition that can safely, effectively increase bone density, easing joint movement.
It is a further object of the present invention to provide the preparation method of this health composition.
It is a still further object of the present invention to provide the application of this health composition.
It is an object of the invention to be accomplished by:
A kind of have increase bone density, the health composition of easing joint movement, and it is made up of the component of following weight portion: sulphuric acid
Chrondroitin 50-150 part, glucosamine 50-150 part, hyaluronic acid 1-10 part, Paecilomyces hepiali Chen et Dai Mycelia 1-10 part, Du
Secondary 20-100 part, Radix Cyathulae 20-100 part, Herba Epimedii 20-100 part, Rhizoma Smilacis Glabrae 20-100 part, Herba Dendrobii 20-50 part, Rhizoma Drynariae 20-
100 parts.
Above-mentioned have increase bone density, the health composition of easing joint movement and be preferably made up of the component of following weight portion: sulfur
Aching and limp ossein 100-150 part, glucosamine 100-150 part, hyaluronic acid 1-5 part, Paecilomyces hepiali Chen et Dai Mycelia 1-5 part,
Cortex Eucommiae 30-50 part, Radix Cyathulae 30-50 part, Herba Epimedii 30-50 part, Rhizoma Smilacis Glabrae 30-50 part, Herba Dendrobii 20-30 part, Rhizoma Drynariae 30-50
Part.
Above-mentioned have increase bone density, the health composition of easing joint movement increases bone density, easing joint movement for preparing
Health care medicine or health food.
Above-mentioned have increase bone density, the health composition of easing joint movement and can be prepared as solid preparation.Described solid
Preparation is preferably granule, capsule, soft capsule, tablet, pill.
The above-mentioned preparation method with the health composition increasing bone density, easing joint movement comprises the following steps:
A. taking the Cortex Eucommiae, Radix Cyathulae, Herba Epimedii, Rhizoma Smilacis Glabrae, Herba Dendrobii according to part by weight, Rhizoma Drynariae Six-element Chinese medicine adds purified water
Heating extraction, united extraction liquid, filters, filtrate is concentrated to give extractum, extract dry, pulverizes, obtain extract powder；
B. take Paecilomyces hepiali Chen et Dai Mycelia, dry, pulverize, sieve, obtain Paecilomyces hepiali Chen et Dai Mycelia fine powder；
C. mixing extract powder and Paecilomyces hepiali Chen et Dai Mycelia powder, obtain medical material powder；
D. add chondroitin sulfate, glucosamine, hyaluronic acid mix homogeneously, to obtain final product.
In the above-mentioned preparation method with the health composition increasing bone density, easing joint movement, in described step a, medical material
Adding purified water heating extraction condition is: extract 2-3 time, extracts 0.5-2 hour every time, and the addition of each purified water is that medical material is total
Weight 10-20 times, united extraction liquid, to filter, it is 1.10-1.50g/ml that filtrate is concentrated into relative density, obtains extractum, and extractum is at 50-
80 DEG C dry, pulverize 50-120 mesh sieve and obtained extract powder.
Peacilomyce hepiahi bacterium in above-mentioned step b with the preparation method increasing bone density, easing joint movement health food
Filament baking temperature 40-70 DEG C, pulverizes, and crosses 50-120 mesh sieve, obtains Paecilomyces hepiali Chen et Dai Mycelia fine powder.
Above-mentioned step d with the preparation method increasing bone density, easing joint movement health food adds chondroitin sulfate,
Glucosamine, hyaluronic acid mixes, and crosses 50-120 mesh sieve.
Above-mentioned have increase bone density, the health composition of easing joint movement and can be used for preparation and increase bone density, easing joint movement,
Prevent and improve the medicine of osteoporosis and arthritis.
The present invention by chondroitin sulfate and glucosamine with the use of, there is pain relieving, promote effect of regenerating bone or cartilage, can
With from improving joint prob at all；Taking glucamine, to absorb chrondroitin extremely important, because chrondroitin can promote Portugal simultaneously
Grapes glucosamine penetrates into the process in joint.Can more effectively protect in conjunction with ingestion of glucose amine and chrondroitin, reverse damage and promote to repair
Compound joint cartilage and membrane bone.The Cortex Eucommiae is sweet, temperature, returns liver, kidney channel；The Cortex Eucommiae has invigorating the liver and kidney, controls spinal column ache, and foot and knee flaccidity is little
Just the heeltap, uncontrolled urination itches, hypertension, antiabortive effect；Herba Epimedii is pungent, sweet, warm；Slow down aging, blood pressure lowering, blood sugar lowering, fall
Blood fat；Radix Cyathulae sweet in the mouth, micro-hardship, property is put down, is had eliminating blood stasis and inducing menstruation, easing joint movement, diuresis inducing function；Rhizoma Smilacis Glabrae sweet in the mouth, light, property
Flat, return liver, stomach warp；There is removing toxic substances, dehumidifying, easing joint movement effect, cure mainly the limbs contracture caused by syphilis and mercurialism, muscles and bones is ached
Bitterly；Damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies；Rhizoma Drynariae bitter in the mouth, warm in nature, there is the kidney invigorating bone strengthening, continue and hinder pain relieving, for kidney
Virtual waist pain, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone；External treatment alopecia areata, vitiligo；Herba Dendrobii sweet in the mouth, cold nature, return
Stomach, kidney channel, have reinforcing stomach reg fluid, nourishing YIN and clearing away heat, hinder for calentura Tianjin, xerostomia excessive thirst, deficiency of stomach-Yin, and lack of appetite is retched, empty after being ill
Heat is not moved back, hyperactivity of fire caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, poor vision, and muscles and bones flaccidity is soft.Seven kinds of Chinese medicines and chondroitin sulfate, glucosamine, thoroughly
Bright matter acid is complemented each other, and makes the purpose that in the present invention, health-care food composition invigorating the kidney and strengthening the bones and easing joint movement are gone together.
Fang Xie: reuse the invigorating the kidney and strengthening the bones of the Cortex Eucommiae, Herba Epimedii and Rhizoma Drynariae in combination, is equipped with Radix Cyathulae, Rhizoma Smilacis Glabrae tonneau pass
Joint, reaches bone strengthening and goes together purpose with profit joint；It is aided with Paecilomyces hepiali Chen et Dai Mycelia and protects lung kidney tonifying effect；Herba Dendrobii enriching yin and nourishing kidney,
Compatibility YIN-tonifying drug among YANG invigorating, takes the justice of " treating YIN within YANG "；Being equipped with chondroitin sulfate in combination, it is close that glucosamine strengthens bone
Degree is used, hyaluronic acid Saving cortilage；Full presciption medicine letter power is special, mild in medicine property and, blending the east and the west, invigorating the kidney and strengthening the bones and easing joint movement, reach
To the function increasing bone density easing joint movement simultaneously.
The present invention uses food grade chondroitin sulfate, the Hepialus armorieanus Oberthur of glucosamine and hyaluronic acid combination integration of edible and medicinal herbs to intend
Waste penicillium biomass, the Cortex Eucommiae, Radix Cyathulae, Herba Epimedii, Rhizoma Smilacis Glabrae, Herba Dendrobii, Rhizoma Drynariae has invigorating the kidney and strengthening the bones, easing joint movement function, suitable
Close osteoporosis, arthritis crowd.
The Paecilomyces hepiali Chen et Dai Mycelia that the present invention uses is commercially available Paecilomyces hepiali Chen et Dai Mycelia powder, meets health care
Raw-food material standard.
Below by way of to concrete test of pesticide effectiveness example, the present composition can be prevented, improve osteoporotic effect and carry out
Further illustrate.
1. material and method
1) use the health food of two embodiments of the present invention as sample sets.
2) laboratory animal: select by 2 monthly age male Sprague-of Qinglongshan animal reproduction field, Jiangning county breeding
Dawley rat.
3) dosage: the health food consumption of the present invention is (body weight 60kg) every day 4 of being grown up, every 3g, is equivalent to 0.2g/
Day/kg.Administration group rat 2 per os every day give, and rat oral gavage volume is 0.01g/100g Mus weight, and sample uses water-soluble rear filling
Stomach.Setting 3 groups of matched groups, blank group use water replaces health food of the present invention, and every day, gavage was identical with sample sets consumption simultaneously.Sulphuric acid
Chrondroitin is identical with sample sets consumption with gavage glucosamine group (both consumptions are same as in Example 1) every day, few Hepialus armorieanus Oberthur
Paecilomycerol filament group (preparation method with embodiment 1, the only few Paecilomyces hepiali Chen et Dai Mycelia of component) gavage every day and sample
Product group consumption is identical.
4) preparation of adenine feedstuff: the preparation of feedstuff is completed by Suzhou Shuan Shi laboratory animal feed companies.By 375g gland
The former powder of purine adds in the muroid feedstuff of 50Kg, fully after mixing, makes the pellet containing 0.75% adenine, seals standby
With.
5) nephropathy osteopathia modeling
After rat adaptability feeds 1 week, give within 4 weeks, to set up chronic nephropathy osteopathia animal containing 0.75% adenine forage feed
Model, freely takes food during modeling, drinks tap water.
6) experimental technique: be randomly divided into 5 groups: example 1 group, 2 groups and 3 matched groups of example.Use nephropathy osteopathia animal model real
Proved recipe method, sample sets is gavage health food of the present invention while giving containing 0.75% adenine forage feed；Matched group gives
Containing 0.75% adenine forage feed.After feeding 4 weeks, jugular vein blood drawing 3ml, stand rear 3000 turns × 5min and be centrifuged, deposit
It is used for detecting serum calcium, PTH, 1,25 (OH) 2D3 foundation level in-80 DEG C of refrigerators.
Experiment shows, administration group serum calcium, PTH relatively 3 matched groups are significantly increased, and serum 1,25 (OH) 2D3 is the most notable
Reducing, there were significant differences (P < 0.05), illustrates that the present invention prevents, and improves nephropathy osteopathia result of the test positive.Simultaneously according to sulphuric acid
With glucosamine group and few Paecilomyces hepiali Chen et Dai Mycelia group, chrondroitin test result indicate that product of the present invention is evident in efficacy excellent
Bone density health product (adding glucosamine as raw material with chondroitin sulfate) are increased in general.
Detailed description of the invention
Form by the following examples, is described in further detail the foregoing of the present invention again, but should be by this
Being interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to Examples below, all technology realized based on foregoing of the present invention are equal
Belong to the scope of the present invention.
Embodiment 1
Formula:
Chondroitin sulfate 100g, glucosamine 100g, Cortex Eucommiae 50g, Radix Cyathulae 50g, Herba Epimedii 50g, Rhizoma Smilacis Glabrae 50g,
Rhizoma Drynariae 50g, Herba Dendrobii 30g, hyaluronic acid 5g, Paecilomyces hepiali Chen et Dai Mycelia 5g.
Preparation method:
A. raw material is made: chondroitin sulfate 100g, glucosamine 100g, Cortex Eucommiae 50g, Radix Cyathulae 50g, Herba Epimedii 50g,
Rhizoma Smilacis Glabrae 50g, Rhizoma Drynariae 50g, Herba Dendrobii 30g, hyaluronic acid 5g, Paecilomyces hepiali Chen et Dai Mycelia 5g；
B. take the Cortex Eucommiae, Radix Cyathulae, Herba Epimedii, Rhizoma Smilacis Glabrae, Herba Dendrobii, Rhizoma Drynariae Six-element Chinese medicine, clean, add purified water extraction 3
Secondary, extraction time is respectively 2 hours, and united extraction liquid filters to obtain clear liquor；It is 1.10g/ that clear liquor is concentrated into relative density
Ml, obtains extractum, and extractum dry, pulverize 120 mesh sieves at 80 DEG C and obtains extract powder；
C. taking Paecilomyces hepiali Chen et Dai Mycelia, 45 DEG C dry, pulverize, and cross 120 mesh sieves, obtain Paecilomyces hepiali Chen et Dai Mycelia thin
Powder；
D. mixing extract powder and Paecilomyces hepiali Chen et Dai Mycelia powder, obtain medical material powder；
E. medical material powder adds chondroitin sulfate, glucosamine, hyaluronic acid and general food auxiliary materials and mixing, crosses 120 mesh
Sieve, 1000 hard capsules of fill, every 3g.
Embodiment 2
Formula:
Chondroitin sulfate 150g, glucosamine 150g, Cortex Eucommiae 30g, Radix Cyathulae 30g, Herba Epimedii 30g, Rhizoma Smilacis Glabrae 30g,
Rhizoma Drynariae 30g, Herba Dendrobii 20g, hyaluronic acid 1g, Paecilomyces hepiali Chen et Dai Mycelia 1g.
Preparation method:
A. raw material is made: chondroitin sulfate 150g, glucosamine 150g, Cortex Eucommiae 30g, Radix Cyathulae 30g, Herba Epimedii 30g,
Rhizoma Smilacis Glabrae 30g, Rhizoma Drynariae 30g, Herba Dendrobii 20g, hyaluronic acid 1g, Paecilomyces hepiali Chen et Dai Mycelia 1g；
B. take the Cortex Eucommiae, Radix Cyathulae, Herba Epimedii, Rhizoma Smilacis Glabrae, Herba Dendrobii, Rhizoma Drynariae Six-element Chinese medicine, clean, add purified water extraction 2
Secondary, extraction time is respectively 1 hour, and united extraction liquid filters to obtain clear liquor；It is 1.50g/ that clear liquor is concentrated into relative density
Ml, obtains extractum, and extractum dry, pulverize 80 mesh sieves at 70 DEG C and obtains extract powder；
C. taking Paecilomyces hepiali Chen et Dai Mycelia, 50 DEG C dry, pulverize, and cross 80 mesh sieves, obtain Paecilomyces hepiali Chen et Dai Mycelia thin
Powder；
D. mixing extract powder and Paecilomyces hepiali Chen et Dai Mycelia powder, obtain medical material powder；
E. add chondroitin sulfate, glucosamine, hyaluronic acid and general food auxiliary materials and mixing, cross 80 mesh sieves, fill
1000 hard capsules, every 3g.
Embodiment 3
Preparing medical material powder according to embodiment 1 method and add chondroitin sulfate, glucosamine, after hyaluronic acid mixing
Granule is prepared according to common process.
Embodiment 4
Prepare medical material powder according to embodiment 1 method and add chondroitin sulfate, glucosamine, hyaluronic acid and food
Prepare granule according to common process after level auxiliary materials and mixing, then tabletting prepares tablet.
Embodiment 5
Prepare medical material powder according to embodiment 1 method and add chondroitin sulfate, glucosamine, hyaluronic acid and food
Honeyed pill is prepared according to common process after level auxiliary materials and mixing.
Embodiment 6
Prepare medical material powder according to embodiment 1 method and add chondroitin sulfate, glucosamine, hyaluronic acid and food
Drop pill is prepared according to common process after level auxiliary materials and mixing.
In above-described embodiment, Paecilomyces hepiali Chen et Dai Mycelia meets " Ministry of Health of the People's Republic of China's ministerial standard " WS3-C1-
0001-95 (Z) " fermented Cordyceps powder (CS-4) ", Jiangsu Shenhua Medicine Co., Ltd produces.
Chondroitin sulfate of the present invention and glucosamine with the use of, there is pain relieving, promote effect of regenerating bone or cartilage, permissible
From improving joint prob at all；The Cortex Eucommiae, Herba Epimedii and Rhizoma Drynariae warming and recuperating the kidney-YANG；Herba Dendrobii enriching yin and nourishing kidney, among YANG invigorating, compatibility is mended
Cloudy medicine, takes the justice of " treating YIN within YANG "；Hyaluronic acid is to constitute the connective tissues such as human body cell interstitial, vitreum, knuckle synovia
Main component；Radix Cyathulae and Rhizoma Smilacis Glabrae have easing joint movement effect；Paecilomyces hepiali Chen et Dai Mycelia has the strong effect of tonification
And enhancing immunologic function；Ten kinds of medicines complement each other, and invigorating the kidney and strengthening the bones is gone together with easing joint movement, and synergism plays preferably increase
Bone density, the function of easing joint movement.
Claims (10)
1. one kind has increase bone density, the health composition of easing joint movement, it is characterised in that it is by the component of following weight portion
Make: chondroitin sulfate 50-150 part, glucosamine 50-150 part, hyaluronic acid 1-10 part, Paecilomyces hepiali Chen et Dai Mycelia
1-10 part, Cortex Eucommiae 20-100 part, Radix Cyathulae 20-100 part, Herba Epimedii 20-100 part, Rhizoma Smilacis Glabrae 20-100 part, Herba Dendrobii 20-50 part,
Rhizoma Drynariae 20-100 part.
The most according to claim 1 have increase bone density, the health composition of easing joint movement, it is characterised in that it is by such as
The component of lower weight portion is made: chondroitin sulfate 100-150 part, glucosamine 100-150 part, hyaluronic acid 1-5 part, Vespertilio
Moth paecilomycerol filament 1-5 part, Cortex Eucommiae 30-50 part, Radix Cyathulae 30-50 part, Herba Epimedii 30-50 part, Rhizoma Smilacis Glabrae 30-50 part, stone
Dry measure used in former times 20-30 part, Rhizoma Drynariae 30-50 part.
The most according to claim 1 and 2 have increase bone density, the health composition of easing joint movement, it is characterised in that should
Health composition is for preparing increase bone density, the health care medicine of easing joint movement or health food.
The most according to claim 1 and 2 have increase bone density, the health composition of easing joint movement, it is characterised in that should
Health composition is prepared as solid preparation.
The most according to claim 4 have increase bone density, the health composition of easing joint movement, it is characterised in that described
Solid preparation is granule, capsule, soft capsule, tablet, pill.
6. the preparation method with the health composition increasing bone density, easing joint movement described in claim 1 or 2, its
It is characterised by that the method comprises the following steps:
A. taking the Cortex Eucommiae, Radix Cyathulae, Herba Epimedii, Rhizoma Smilacis Glabrae, Herba Dendrobii according to part by weight, Rhizoma Drynariae Six-element Chinese medicine adds purified water heating
Extract, united extraction liquid, filter, filtrate is concentrated to give extractum, extract dry, pulverizes, obtain extract powder；
B. take Paecilomyces hepiali Chen et Dai Mycelia, dry, pulverize, sieve, obtain Paecilomyces hepiali Chen et Dai Mycelia fine powder；
C. mixing extract powder and Paecilomyces hepiali Chen et Dai Mycelia powder, obtain medical material powder；
D. add chondroitin sulfate, glucosamine, hyaluronic acid mix homogeneously, to obtain final product.
The preparation method with the health composition increasing bone density, easing joint movement the most according to claim 6, its feature
Being, in described step a, heating extraction condition is: extract 2-3 time, extracts 0.5-2 hour, the addition of each purified water every time
It is medical material gross weight 10-20 times, united extraction liquid, to filter, it is 1.10-1.50g/ml that filtrate is concentrated into relative density, obtains extractum, leaching
Cream dry, pulverize 50-120 mesh sieve at 50-80 DEG C and obtained extract powder.
The most according to claim 6 have increase bone density, the preparation method of easing joint movement health food, and its feature exists
In, Paecilomyces hepiali Chen et Dai Mycelia baking temperature 40-70 DEG C in described step b, pulverize, cross 50-120 mesh sieve, obtain Hepialus armorieanus Oberthur and intend
Waste penicillium biomass fine powder.
The most according to claim 6 have increase bone density, the preparation method of easing joint movement health food, and its feature exists
In: described step d adds chondroitin sulfate, glucosamine, and hyaluronic acid mixes, and crosses 50-120 mesh sieve.
10. having described in claim 1 or 2 increases bone density, the health composition of easing joint movement is being prepared for increasing bone
Density, easing joint movement, prevent and improve the application in the medicine of osteoporosis and arthritis.
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Application publication date: 20161130 |