CN104666581A - Health care product for enhancing bone density and improving immunity and preparation method of health care product - Google Patents
Health care product for enhancing bone density and improving immunity and preparation method of health care product Download PDFInfo
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Abstract
The invention provides a health care product for enhancing bone density and improving immunity and a preparation method of the health care product. The health care product has the functions of enhancing bone density, repairing cartilage tissues and improving immunity. Mainly based on tonifying the liver and kidney and assisting the functions of dispelling wind and eliminating dampness and promoting blood circulation to remove blood stasis, the product further improves the adverse environment of damaged regions of rheumatoid bone diseases, so that treatment on both symptoms and root causes is realized. The health care product has the functions of treating cervical spondylosis, lumbar spondylosis, degenerative arthritis, rheumatic arthritis or rheumatoid arthritis and the like. By adopting decoction pieces corn cervi pantotrichum, achyranthes bidentata, prepared rehmannia roots, roots of kudzu vines, herba epimedii and the like which are combined, the product hits the pathogenesis of deficiency of the kidney, insufficiency of the spleen and blood stasis of osteoporosis and that of deficiency of kidney storing congenital vital essence and spleen governing water valley of immunocompromised people, the full formula has the functions of tonifying liver and kidney, tonifying spleen, enriching blood, promoting blood circulation to remove blood stasis, strengthening tendons and bones and strengthening body resistance and eliminating evil, achieves the health care functions of enhancing the bone density and improving the immunity, and has remarkable effects on various bone diseases.
Description
Technical field
The present invention relates to Chinese medicine health care product and preparation field thereof, be specifically related to a kind of for strengthening bone density and improving the preparation method of the health product of immunity and corresponding health product.
Background technology
Middle-aged and elderly people, especially often easily there is the situation such as osteoporosis, hypoimmunity in more than 45 years old women, more than 50 years old male, brings very large threat to the health of middle-aged and elderly people.And along with the growth along with the age, people also easily suffer from some osteopathia, such as cervical spondylosis, lumbar spondylosis, gonarthrosis, rheumatoid arthritis.
At present, doctor trained in Western medicine generally believes that osteoporosis causes due to calcium deficiency, therefore, often takes the most directly mode, namely replenish the calcium for osteoporotic patient, to improve bone density.Doctor trained in Western medicine thinks bone density, i.e. " bone mineral density ", is the important symbol of bone mass, and reflection osteoporosis degree, bone density height can be used as the important evidence of prediction fracture probability.
At present, the health food for increasing bone density mainly contains: 1. calcium: calcium is the essential minerals that skeleton and tooth are organized in the materialization of health chats, is the basal nutrient maintaining bone density, is also the important dietary factors affecting bone density.Will bring out hyperparathyroidism when calcium is taken in or calcium absorption is not enough, then cause the bone from skeleton to be mobilized, discharge more calcium to maintain the calcium stable of serum, therefore bone loss occurs.Therefore, the status of calcium in prevention and therapy osteoporosis is extremely important and irreplaceable.2. vitamin D: level and the bone density of body vitamin D are closely related.Vitamin D is the main regulate factors of calcium absorption, can help absorption of human body calcium, effectively improve human bone mineral density.It may be one of major reason causing senile osteoporosis to occur that the quantity of vitamin D and usefulness reduce; Suitable vitamin D can delay bone loss, reduces incidence of fracture.3. soybean isoflavone, soybean saponin.
But, above-mentioned for material for enhancing bone density, be all that index is not effected a permanent cure, it is only provide corresponding material according to the composition of skeleton, does not find and strengthens the essence factor of bone density, to the immune system of health also without any help.And these products above-mentioned produce little effect for the treatment of various osteopathia.
Therefore, people wish a kind ofly can strengthen bone density, treatment osteopathia and improve the product of body immunity.
Summary of the invention
For the problems referred to above, the present invention is desirable to provide a kind of osteopathia (lumbar spondylosis, cervical spondylosis, arthritis etc.) that fundamentally can strengthen bone density, treatment human body, and improve the preparation method of the health product of user's immunity, and corresponding health promoting product.
On the one hand, the invention provides a kind of for strengthening bone density and improving the preparation method of the health product of immunity, described method comprises:
Step 1): Radix Achyranthis Bidentatae and the Radix Rehmanniae Preparata of getting scheduled volume, mix the two and be placed in water and decoct the scheduled time;
Step 2): decoction gained Aqueous extracts is leached, discards medicinal residues;
Step 3): obtained Aqueous extracts is carried out concentrating under reduced pressure, obtains the first thick extractum;
Step 4): Radix Puerariae and the Herba Epimedii of getting scheduled volume, carry out one or many alcohol extraction to the two;
Step 5): obtained alcohol extract is concentrated, obtains the second thick extractum;
Step 6): described first thick extractum and described second thick extractum are merged, carries out dried, obtain dry extract;
Step 7): obtained dry extract is pulverized and filters, obtain extract extract powder;
Step 8): the cervus elaphus linnaeus getting scheduled volume, make cervus elaphus linnaeus powder;
Step 9): described cervus elaphus linnaeus powder is mixed homogeneously with described extract extract powder.
In the present invention, dry run preferably adopts vacuum drying mode, certainly, does not get rid of and also can adopt other drying modes.Water used herein can, for meeting the drinking water of national standard, also can be purified water.
Further, described method also comprises and carrying out described cervus elaphus linnaeus
60co irradiation sterilization, dosage is 5kGy.
Further, described step 5) comprise the decoction pieces Radix Puerariae, the Herba Epimedii that take formula ratio and put in (positive cone) extraction pot, add 8-10 times amount 70% ethanol respectively, reflux, extract, 2 times, each 2 hours, filter respectively, merging filtrate, obtain alcohol extract.
Further, by weight, each material quantity adopted is: cervus elaphus linnaeus 70-90 part, Radix Achyranthis Bidentatae 400-600 part, Radix Puerariae 350-620 part, Radix Rehmanniae Preparata 400-510 part, Herba Epimedii 210-430 part.
Further, described method also comprises and adds Massa Medicata Fermentata 120-140 part, Pericarpium Citri Reticulatae 75-95 part in said products.
On the other hand, the invention provides a kind of for strengthening bone density and improving the health product of immunity, it is characterized in that, described health product comprise: cervus elaphus linnaeus, Radix Achyranthis Bidentatae, Radix Puerariae, Radix Rehmanniae Preparata, Herba Epimedii, or cervus elaphus linnaeus, Radix Achyranthis Bidentatae, Radix Puerariae, Radix Rehmanniae Preparata, Herba Epimedii extract.
Further, in described health product, comprise the powder of cervus elaphus linnaeus 70-90 part, the dried powder of the water extract of Radix Achyranthis Bidentatae 400-600 part and Radix Rehmanniae Preparata 400-510 part, the dried powder of the ethanol extract of Radix Puerariae 350-620 part and Herba Epimedii 210-430 part.
Further, described health product comprise the powder of cervus elaphus linnaeus 85 parts, the dried powder of the water extract of Radix Achyranthis Bidentatae 500 parts and Radix Rehmanniae Preparata 450 parts, the dried powder of the ethanol extract of Radix Puerariae 500 parts and Herba Epimedii 333 parts.
On the other hand, the invention provides a kind of application of described health product, it is characterized in that, described health product are used for the treatment of osteopathia.
Further, described osteopathia comprises cervical spondylosis, lumbar spondylosis, gonarthrosis, rheumatoid arthritis.Product of the present invention treats osteopathia mainly through repairing damaged cartilage.
It should be noted that, various raw material of the present invention is commercially available conventional Chinese crude drug.
Introduce foundation and the principle of formula of the present invention below.Applicant thinks osteopathia, no matter is cervical spondylosis, lumbar spondylosis, or gonarthrosis etc., it is impaired relevant that its morbidity is all organized with cartilage, fibrous ring and synovial membrane etc.Therefore, repairing the tissues such as damaged cartilage, fibrous ring and synovial membrane, make it regenerate, is the key for the treatment of osteopathia.
Repairing damaged cartilage one is external source replacement therapy, as directly supplemented the main component D-glucosamine etc. of the tissues such as cartilage, fibrous ring and synovial membrane for human body, found that curative effect is not very good, because D-glucosamine etc. is difficult to directly absorbed by the body.
A kind of is the endogenous source therapy of Chinese Medicine Thinking, by mend ingeniously strengthen the tissues such as human body cartilage, fibrous ring and synovial membrane Endogenous system---Liver and kidney (think by the traditional Chinese medical science, liver governing tendons, kidney governing bones, so Liver and kidney is the endogenous origin head of the tissues such as human body cartilage, fibrous ring and synovial membrane), repair the tissues such as impaired cartilage, fibrous ring and synovial membrane, make it regenerate, clinical effectiveness obtains certainly.
Department of Chinese medicine institute of China chief rheumatic osteopathia expert professor Feng Xinghua thinks, the treatment of rheumatic osteopathia will be set about from the source of morbidity, with skilful invigorating the liver and kidney for this, assistant is with expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, takes into account and improves rheumatic osteopathia affected area adverse environment for mark, realize treating both the principal and secondary aspects of a disease." skilful invigorating the liver and kidney, regenerating bone or cartilage " reach source side (i.e. product of the present invention), just professor Feng Xinghua rely on more than 50 year treatment rheumatic osteopathia clinical experience and create.The medical material of this Fang Qiaoxuan " invigorating the liver and kidney, the tissues such as interior raw cartilage ", strict exquisite monarch and Gui Jing, the morbidity source of through rheumatic osteopathia.
The present invention, from traditional Chinese medical science legislation, is mainly divided into two aspects " this and mark ", i.e. treating both the principal and secondary aspects of a disease.
1. nourishing YIN and invigorating YANG, giving young employees remedial-courses in general knowledge and vocational skills Liver and kidney (Cornu Cervi Pantotrichum, Radix Rehmanniae Preparata etc.), effects a permanent cure.
The present invention, by selecting the Chinese crude drug compatibility of the giving young employees remedial-courses in general knowledge and vocational skills such as Cornu Cervi Pantotrichum, Radix Rehmanniae Preparata Liver and kidney ingeniously, takes the cartilage, fibrous ring and the synovial membrane Endogenous system that strengthen human body afterwards, namely strengthens hepatic and renal function, improve the self-repairing capability organized cartilage, fibrous ring and synovial membrane etc.
In addition, experiment proves, after the medical material such as Cornu Cervi Pantotrichum, Radix Rehmanniae Preparata compatibility is taken, effectively can promote the synthesis of protein and nucleic acid, and protein and nucleic acid be cartilage, the base substance that generates such as annulus fibrosus disci intervertebralis, synovium of joint, knuckle synovia.And Cornu Cervi Pantotrichum YANG invigorating, Radix Rehmanniae Preparata YIN nourishing, by the ingenious compatibility (ingenious both selections proportioning) of the Chinese crude drug such as Cornu Cervi Pantotrichum, Radix Rehmanniae Preparata, strengthen Endogenous system---the hepatic and renal function of human body cartilage, fibrous ring and synovial membrane, improve the repair ability to human body cartilage, fibrous ring and synovial membrane, realize effecting a permanent cure from source.
2. expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling (Herba Epimedii, Radix Achyranthis Bidentatae, Radix Puerariae etc.), takes stopgap measures.
During Liver and kidney deficiency in origin, wind-cold damp pathogen very easily attacks human body, and numbness passages through which vital energy circulates, causes blood vessels to stagnate, the poor blood circulation of osteopathia damaged part, is unfavorable for that the nutrition supply of damaged part tissue and inflammation are eliminated.
(1) removing cold and wind damp.The medical materials such as Herba Epimedii, can cold-dispelling damp, again can invigorating yangqi, can efficient solution stagnating except blood vessels.
(2) conducting blood to flow downwards, blood circulation promoting and blood stasis dispelling.Radix Achyranthis Bidentatae, can conducting blood to flow downwards, again can blood circulation promoting and blood stasis dispelling, Herba Epimedii etc. can be coordinated effectively to improve the local environment of waist, knee joint damaged part, blood circulation promoting, increase needed for endotrophic, reducing swelling and alleviating pain.
(3) yang invigorating expelling pathogenic factors from muscles, blood circulation promoting and blood stasis dispelling.Because of caused by liver and kidney deficiency, wind-cold damp pathogen invasion and attack neck, coagulation of QI-blood meridians, cause neck rigidity, and muscle muscle arteries and veins is had a pain.Radix Puerariae, is the good medicine for the treatment of cervical spondylosis, can coordinates the removing cold and wind damps such as Herba Epimedii, invigorating yangqi, yang invigorating expelling pathogenic factors from muscles, can promote again the blood circulation at neck position, accelerates the reparation of damaged cartilage, fibrous ring etc.
The present invention is by the ingenious compatibility (proportionings of ingenious selection three kinds of medical materials) of the Chinese crude drugs such as Herba Epimedii, Radix Achyranthis Bidentatae, Radix Puerariae, removing cold and wind damp, invigorating yangqi, reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling, improve osteopathia damaged part blood circulation, increase the nutrition supply of damaged cartilage, fibrous ring and synovial membrane etc., realize taking stopgap measures.
Therefore, product of the present invention can strengthen bone density, repairs cartilaginous tissue, and can realize treating both the principal and secondary aspects of a disease for osteopathia such as lumbar vertebra, cervical vertebra, arthritis.
Accompanying drawing explanation
Fig. 1 is the simplification of flowsheet figure of health product preparation method of the present invention.
Fig. 2 is the refinement flow chart of health product preparation method of the present invention.
Detailed description of the invention
Below in conjunction with Fig. 1 and Fig. 2, embodiments of the invention are further elaborated.
Embodiment one
1, raw material, adjuvant require and pre-treatment
Prepare raw material decoction pieces cervus elaphus linnaeus, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Radix Puerariae, Herba Epimedii and supplementary product starch, magnesium stearate etc. respectively.And prepare for extracting and the drinking water of preparation or purified water.
Decoction pieces cervus elaphus linnaeus is carried out
60co irradiation sterilization, dosage is 5kGy, and the cervus elaphus linnaeus after irradiation is for subsequent use; Decoction pieces Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Radix Puerariae, Herba Epimedii are weighed by formula ratio respectively, for subsequent use; Supplementary product starch, magnesium stearate cross 80 mesh sieves respectively, weigh by formula ratio, for subsequent use.
Each proportioning raw materials is as following table:
2, feed intake, extract
Take the decoction pieces Radix Achyranthis Bidentatae of formula ratio, Radix Rehmanniae Preparata puts in positive cone extraction pot, add 10 times amount (purification) water respectively, decoct extraction 2 times, extract 1.5h at every turn, filter respectively, merging filtrate, obtain Aqueous extracts.Medicinal residues discard.
Take the decoction pieces Radix Puerariae of formula ratio, Herba Epimedii puts in positive cone extraction pot, add 8 times amount 70% ethanol respectively, reflux, extract, 2 times, each 2 hours, filter respectively, merging filtrate, obtain alcohol extract.Medicinal residues discard.
3, concentrated
Aqueous extracts is put in vacuum concentration pot, be evaporated to relative density 1.20-1.25 (measuring under about 60 DEG C of conditions), obtain thick extractum I.Concentrating under reduced pressure technological parameter: vacuum 0.08MPa, temperature 65 ~ 75 DEG C.
Alcohol extract is put in vacuum concentration pot, be evaporated to without alcohol taste, reclaim ethanol, and continue to be concentrated into relative density 1.20-1.25 (measuring under about 60 DEG C of conditions), obtain thick extractum II.Concentrating under reduced pressure technological parameter: vacuum 0.08MPa, temperature 55 ~ 65 DEG C.
4, dry, pulverizing
Thick extractum I is merged with thick extractum II, puts in vacuum drying oven and carry out vacuum drying (technological parameter: vacuum 0.08MPa, temperature 70 ~ 80 DEG C), obtain dry extract, dry extract is put in pulverizer and pulverizes, cross 80 mesh sieves, obtain extract extract powder, for subsequent use.
Will be through
60the cervus elaphus linnaeus of Co irradiation sterilization is put in pulverizer and is pulverized, and crosses 80 mesh sieves, obtains cervus elaphus linnaeus powder, take by formula ratio, for subsequent use.
5, mix
Said extracted thing extract powder, cervus elaphus linnaeus powder, starch and magnesium stearate are put in mixer and mix 20 minutes, obtain mixed powder.Mixed powder answers uniform color consistent, no color differnece.
6, filled capsules, polishing, capsule is selected
Mixed powder is used Autocapsulefillingmachine filled capsules, use 0# Capsules, filling specification is 0.45g/ grain, and content uniformity controls in ± 5% scope.Capsule after filling is carried out polishing in capsule polisher, removes inferior defective work of Denging.
7, inner packing
Qualified capsule is loaded plastic bottle, 60 every bottle.Packaging material are oral stable medicinal polythene bottle with high density (meeting the standard-required of YBB00122002).
8, outer package, product inspection, warehouse-in:
Label, case.Randomly draw and often criticize product, test according to method described in quality standard and requirement, after the assay was approved, finished product is put in storage.
9, production environment and management should meet the requirement of health food GMP, vacuum drying in production process, pulverize, sieve, mix, capsule-filling and inner packing process all operate under meeting GB17405-1998 to require the production clean area condition of (being 100,000 grades).
After preparing product of the present invention, in order to verify effect of the present invention, need to carry out clinical verification to product of the present invention.Specifically, applicant provides product of the present invention to carry out clinical verification (when appointing confidentiality obligations) to the patient that position up to a hundred suffers from arthritis, lumbar spondylosis or cervical spondylosis in clinical, then, respectively regular further consultation is carried out to the effect after up to a hundred patient consumes.
By measuring these bone mineral densities, can find, patient is 2-3 week after the tablet has been ingested, and bone density will obviously increase, and cervical spondylosis and lumbar spondylosis all can have obvious improvement.And 4-6 is all after the tablet has been ingested, the disease such as synovitis, rheumatoid arthritis all can be almost recovered.And by the mensuration to pill taker's immunity albumen, also can find, the content of patient's immune protein after the tablet has been ingested of taking medicine adds.
Therefore, suffice to show that product of the present invention can strengthen bone density, treatment osteopathia and, improve body immunity.And currently used medicine, often or only for bone density, or only treat osteopathia, be difficult to the increase both having realized bone density, realize again the treatment of osteopathia and the lifting of immunity.
Embodiment two
In the present embodiment, the preparation method adopted is substantially identical with embodiment one, and just each component content of formula has carried out suitable adjustment.
This formula more stresses effecting a permanent cure for osteopathia, therefore, more long-acting after taking.
Embodiment three
In the present embodiment, the preparation method adopted and embodiment one substantially similar, be just carried out suitable adjustment at formula.
Specifically, its formula is as following table
In above-mentioned material, Radix Morindae Officinalis and Fructus Lycii adopt the mode (adding in the step of alcohol extraction) of alcohol extraction, obtain dried powder after alcohol extraction.The mode (adding in the step of water extraction) of Fructus Amomi Rotundus, Massa Medicata Fermentata, Pericarpium Citri Reticulatae employing water extraction.After with the addition of above-mentioned adjuvant, the better effects if for the treatment of osteopathia, stimulates less to the intestines and stomach of patient, promotes that people digest absorbs.
It should be noted that; although with specific embodiments and the drawings describes in detail invention has been above; but; description is above only schematically illustrate; so that those skilled in the art's the understanding of the present invention, the restriction of detail not to invention protection domain of parts shown in figure.Those skilled in the art also should be appreciated that, above-described embodiment is also only the explanation to exemplary implementation of the present invention, not limiting the scope of the invention.
Claims (10)
1., for strengthening bone density and improving the preparation methoies of the health product of immunity, described method comprises:
Step 1): Radix Achyranthis Bidentatae and the Radix Rehmanniae Preparata of getting scheduled volume, mix the two and be placed in water and decoct the scheduled time;
Step 2): decoction gained Aqueous extracts is leached, discards medicinal residues;
Step 3): obtained Aqueous extracts is carried out concentrating under reduced pressure, obtains the first thick extractum;
Step 4): Radix Puerariae and the Herba Epimedii of getting scheduled volume, carry out one or many alcohol extraction to the two;
Step 5): obtained alcohol extract is concentrated, obtains the second thick extractum;
Step 6): described first thick extractum and described second thick extractum are merged, carries out dried, obtain dry extract;
Step 7): obtained dry extract is pulverized and filters, obtain extract extract powder;
Step 8): the cervus elaphus linnaeus getting scheduled volume, make cervus elaphus linnaeus powder;
Step 9): described cervus elaphus linnaeus powder is mixed homogeneously with described extract extract powder.
2. the preparation method of health product according to claim 1, is characterized in that, described method also comprises carries out described cervus elaphus linnaeus
60co irradiation sterilization, dosage is 5kGy.
3. the preparation method of health product according to claim 1, it is characterized in that, described step 5) comprise the decoction pieces Radix Puerariae, the Herba Epimedii that take formula ratio and be placed in extraction pot, add 8-10 times amount 70% ethanol respectively, reflux, extract, 2 times, each 2 hours, filters respectively, merging filtrate, obtains alcohol extract.
4. the preparation method of health product according to claim 1, is characterized in that, by weight, each material quantity adopted is: cervus elaphus linnaeus 70-90 part, Radix Achyranthis Bidentatae 400-600 part, Radix Puerariae 350-620 part, Radix Rehmanniae Preparata 400-510 part, Herba Epimedii 210-430 part.
5. the preparation method of health product according to claim 4, is characterized in that, described method also comprises and adds Massa Medicata Fermentata 120-140 part, Pericarpium Citri Reticulatae 75-95 part in said products.
6., for strengthening bone density and improving the health product of immunity, it is characterized in that, described health product comprise: cervus elaphus linnaeus, Radix Achyranthis Bidentatae, Radix Puerariae, Radix Rehmanniae Preparata, Herba Epimedii, or cervus elaphus linnaeus, Radix Achyranthis Bidentatae, Radix Puerariae, Radix Rehmanniae Preparata, Herba Epimedii extract.
7. health product according to claim 6, it is characterized in that, the powder of cervus elaphus linnaeus 70-90 part is comprised, the dried powder of the water extract of Radix Achyranthis Bidentatae 400-600 part and Radix Rehmanniae Preparata 400-510 part, the dried powder of the ethanol extract of Radix Puerariae 350-620 part and Herba Epimedii 210-430 part in described health product.
8. health product according to claim 6, is characterized in that, described health product comprise the powder of cervus elaphus linnaeus 85 parts, the dried powder of the water extract of Radix Achyranthis Bidentatae 500 parts and Radix Rehmanniae Preparata 450 parts, the dried powder of the ethanol extract of Radix Puerariae 500 parts and Herba Epimedii 333 parts.
9. according to an application for the health product described in claim 6-8, it is characterized in that, described health product are used for the treatment of osteopathia.
10. application according to claim 9, is characterized in that, described osteopathia comprises cervical spondylosis, lumbar spondylosis, gonarthrosis, rheumatoid arthritis.
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| CN113170883A (en) * | 2021-04-26 | 2021-07-27 | 吉林大清鹿苑保健科技有限公司 | Health food for increasing bone mineral density and preparation method thereof |
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| CN113170883A (en) * | 2021-04-26 | 2021-07-27 | 吉林大清鹿苑保健科技有限公司 | Health food for increasing bone mineral density and preparation method thereof |
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