CN102133395A - Skeleton health-care product or medicinal composite and application thereof - Google Patents
Skeleton health-care product or medicinal composite and application thereof Download PDFInfo
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Abstract
The invention relates to a skeleton health-care product or a medicinal composite, which comprises the following raw materials in part by weight: 160,000 to 185,000 parts of calcium carbonate, 1 to 2 parts of vitamin D3, 11,000 to 13,000 parts of casein phosphoeptide, 30,000 to 50,000 parts of chondroitin sulfate, 80,000 to 100,000 parts of glucosamine hydrochloride, 50,000 to 70,000 parts of ossein and 1,150 to 1,500 parts of manganese chloride. The skeleton health-care product or the medicinal composite has a skillful and unique design, mutually-synergistic components and high bioavailability, can be used for increasing bone mineral density, relieving bone pain, restoring bone functions and improving immunity, treats the symptoms of osteoporosis, bone pain, loss of bone joint functions and the like, can be prepared into a compound preparation, does not have toxic or side effect, and is suitable for large-scale popularization and application.
Description
Technical field
Thing or pharmaceutical composition technical field the present invention relates to keep healthy, be particularly related to skeleton health care thing or pharmaceutical composition technical field, specifically be meant a kind of skeleton health care thing or pharmaceutical composition and application thereof, this skeleton health care thing or pharmaceutical composition can be used for bone density improving and alleviate bone pain recovery bone function raising immunity.
Background technology
Osteoarthrosis such as osteoporosis have become one of most important public health problem of developed country, also are the more and more distinct issues that developing country need face.American-European countries report, osteoporotic fracture can take place in 30% women and 12% man in life, the medical care expenses of being spent in Britain and the U.S. up to 1,400,000,000 and 15,000,000,000 dollars.The hip fracture rate that the result of Asia area osteoporotic fracture Epidemiological study in the recent period shows Hong-Kong and Singapore is than having increased by 3 times the sixties in 20th century, and the change of environmental factorss such as this mainly increases sharply with elderly population, life style is relevant.
Along with the aged crowd of China increases, the socioeconomic obvious change that develops rapidly with life style, change as dietary structure, physical exertion minimizing etc., make osteoporosis and serious consequence thereof fracture also become the more and more serious community health problem of China, therefore everybody should attract great attention, and prevents and treats early.
Therefore, need provide a kind of skeleton health care thing or pharmaceutical composition, it can be used for bone density improving alleviates bone pain and recovers the bone function and improve immunity, thereby for ensureing that human health makes certain contribution.
Summary of the invention
The objective of the invention is to have overcome above-mentioned shortcoming of the prior art, a kind of skeleton health care thing or pharmaceutical composition and application thereof are provided, this skeleton health care thing or pharmaceutical composition design ingenious uniqueness, take mutually between component together, the bioavailability height can be used for bone density improving and alleviate bone pain recovery bone function raising immunity, obviously solve osteoporosis, bone pain, and symptom such as osteoarthrosis afunction, and can be made into compound preparation, have no side effect, be suitable for large-scale promotion application.
To achieve these goals,, provide a kind of skeleton health care thing or pharmaceutical composition, be characterized in, formed by following materials based on weight: the calcium carbonate of 160000～185000 weight portions, the vitamin D of 1～2 weight portion in a first aspect of the present invention
3, the phosphopeptide caseinate of 11000～13000 weight portions, the chondroitin sulfate of 30000～50000 weight portions, the ossein of the glucosamine hydrochloride of 80000～100000 weight portions and 50000～70000 weight portions, the manganese chloride of 1150～1500 weight portions.
Preferably, described calcium carbonate is 168000～180000 weight portions, described vitamin D
3It is 1～2 weight portion, described phosphopeptide caseinate is 11500～12500 weight portions, described chondroitin sulfate is 40000～50000 weight portions, described glucosamine hydrochloride be 88000～95000 weight portions with described ossein be 55000～65000 weight portions, the manganese chloride of 1200～1450 weight portions.
Best, described calcium carbonate is 173333 weight portions, described vitamin D
3Be 1 weight portion, described phosphopeptide caseinate is 12000 weight portions, and described chondroitin sulfate is 46667 weight portions, described glucosamine hydrochloride be 93333 weight portions with described ossein be 60000 weight portions, described manganese chloride is 1333 weight portions.
Above-mentioned compound basis is as follows:
Modern medicine study proves that many factors can influence people's bone density: the living habit that (1) is bad: all can reduce bone density and then cause osteoporosis as long-term excessive drinking and smoking.(2) trophic factor: the normal growth of osseous tissue and growth need an amount of calcium to take in, and have only the calcium of capacity to take the photograph the people in adolescence and just can reach best peak bone density.(3) exercise factor: motion is necessary to normal bone mineralising, and the positive outdoor exercise activity of adolescence is very definite to the influence of peak bone density.(4) endocrine hormone: androgen has been kept important regulating action to the growth of male's normal bone, metabolism, bone amount.This effect is by autoreceptor mediation, on the surface of the endotheliocyte of osteoblast, osteoclast, osteocyte, marrow stromal cell and blood vessel androgen receptor arranged all.Estrogen is to existing estrogen receptor defects or synthetic estrogen.Parathyroid hormone can increase osteoblast number and activity, is osteoblast by the cell transformation of guiding bone liner, and does not need to stimulate the propagation of precursor, can also stop osteoblast to be transferred and die, and plays an important role in the mineralising of regulating bone matrix.(5) oxidative stress more and more comes into one's own as an osteoporotic risk factor in recent years.There are some researches show that too much free radical can suppress osteoblastic differentiation in the bone marrow during oxidative stress status, stimulate the osteoclast differentiation simultaneously, bone density is reduced, promoted osteoporotic the development.
A large amount of researchs prove that also many functional factors all have certain bone density improving function, but their mechanism is had nothing in common with each other: 1) calcium is the basic nutrition of maintaining bone density, also is an important dietary factors that influences bone density.When calcium absorption or calcium absorption deficiency, will bring out hyperparathyroidism, cause then mobilizing, discharge more calcium to keep the calcium stable of serum from the bone of skeleton.Therefore bone loss takes place.Therefore, the status of calcium in prevention and treatment osteoporosis is very important and irreplaceable; 2) body vitamin D
3Level and bone density, the strong density of muscle is relevant, vitamin D
3Be the main adjusting factor of calcium absorption, can help absorption of human body calcium, improve the human body bone density effectively and take in the peak value that calcium can be kept to the long duration bone density.Shortage or not enough human body also can cause the Secondary cases parathyroid function to increase to the incomplete absorption 10% of calcium, increase the bone conversion, promote bone loss, cause osteoporosis and fracture; 3) phosphopeptide caseinate promotes absorbing of divalent minerals such as calcium; 4) chondroitin sulfate can promote osteoblastic propagation in vivo, promote osteoblastic mineralising, and chondroitin sulfate also has very strong antioxidant activity, and this all helps the development of delaying osteoporosis and improves bone density; 5) glucosamine hydrochloride has very strong antioxidant activity, helps the development of delaying osteoporosis, thus bone density improving relatively; 6) bone collagen can make calcium effectively be deposited on the skeleton, improve the absorbance of calcium, the calcium that human body absorbed, the interconnect function by collagen protein is just effectively utilized by skeleton just, have only enough osseins of replenishing, could guarantee the rational proportion of skeleton composition.7) manganese: be the composition that constitutes the human body plurality of enzymes, the enzyme of especially synthetic cartilaginous tissue and the active enzyme of promotion osteoblast, these two kinds of enzymes are good catalyst, can accelerate to promote the synthetic and bone calcium deposition of cartilage.Manganese can also promote the synthetic of superoxide dismutase, promotes albumen synthetic.
The compatibility relationship of skeleton health care thing of the present invention or pharmaceutical composition: formula components is from different perspectives, promotes the absorption of calcium and the deposition on skeleton by different mechanism, suppress the dissolving and the loss of calcium, promote the formation of bone matrix, thereby bone density is increased, reduce bone pain, recover the bone function.Wherein, calcium carbonate is the calcium source that replenishes, directly at the low material base of bone density; Phosphopeptide caseinate and the absorption of vitamin D3 with different mechanism promotion calcium; Glucosamine hydrochloride and chondroitin sulfate mainly reduce the generation that bone density reduces with antioxidative mechanism; Ossein can make calcium effectively be deposited on the skeleton, the calcium that human body absorbed, and the interconnect function by collagen protein is just effectively utilized by skeleton just; Manganese can accelerate to promote the synthetic and bone calcium deposition of cartilage.
In a second aspect of the present invention, provide above-mentioned skeleton health care thing or the application of pharmaceutical composition in preparation skeleton health product or medicine.For example, by being mixed, this skeleton health care thing or pharmaceutical composition and edibility adjuvant or pharmaceutically acceptable carrier etc. make skeleton health product or medicine.
For example, a kind of skeleton health product or medicine can prepare by the following method: 1, all raw materials are crossed 60 mesh sieves; 2, take by weighing each raw material by formula proportion; 3, mix: the mixer rotating speed is 60 rev/mins, and incorporation time is 45 minutes; 4, on automatic capsule filling machine, 0# capsule, 0.58 gram/grain carry out capsule and fill; 5, capsule polishing; 6, bottling.
Beneficial effect of the present invention is specific as follows: skeleton health care thing of the present invention or pharmaceutical composition, form by following materials based on weight: the calcium carbonate of 160000～185000 weight portions, the vitamin D of 1～2 weight portion
3The phosphopeptide caseinate of 11000～13000 weight portions, the chondroitin sulfate of 30000～50000 weight portions, the ossein of the glucosamine hydrochloride of 80000～100000 weight portions and 50000～70000 weight portions, the manganese chloride of 1150～1500 weight portions, design ingenious uniqueness, take mutually between component together, the bioavailability height, can be used for bone density improving and alleviate bone pain recovery bone function raising immunity, obviously solve osteoporosis, bone pain, reach symptoms such as osteoarthrosis afunction, and can be made into compound preparation, have no side effect, be suitable for large-scale promotion application.
The specific embodiment
In order more to be expressly understood technology contents of the present invention, describe the present invention below by specific embodiment.
Embodiment 1 prescription screening
The purpose of this prescription screening is to study simple calcium and vitamin D supplement and increases the difference of composition aspect the bone density improving effect such as helping bone matrix formation and antioxidation on this basis.
1.1, prescription forms and dosage
| ? | Control formula | The research prescription |
| Prescription is formed | Calcium carbonate 99.9g, vitamin D3 5mg | Prescription 1, prescription 2, prescription 3 |
| People's dosage | 0.017g/kg?BW | 0.058g/kg?BW |
| The dosage of rat | 0.17g/kg?BW | 0.58g/kg?BW |
First kind of prescription (prescription 1): calcium carbonate 260g, vitamin D3 1.5mg, phosphopeptide caseinate 18g, chondroitin sulfate 70g, glucosamine hydrochloride 140g, ossein 90g, manganese chloride 2g;
Second kind of prescription (prescription 2): calcium carbonate 185g, vitamin D3 1mg, phosphopeptide caseinate 13g, chondroitin sulfate 50g, glucosamine hydrochloride 80g, ossein 50g, manganese chloride 1.5g;
The third prescription (prescription 3): calcium carbonate 160g, vitamin D3 2mg, phosphopeptide caseinate 11g, chondroitin sulfate 30g, glucosamine hydrochloride 100g, ossein 70g, manganese chloride 1.15g;
1.2, laboratory animal: SPF level SD kind male and healthy rat is provided by Chinese Academy of Sciences's Shanghai Experimental Animal Center that (quality certification number: No. the 003rd, middle section moving pipe word), body weight: 71.26 ± 4.83g, pellet are also provided by Chinese Academy of Sciences's Shanghai Experimental Animal Center.
1.3 experiment grouping: control formula group and research prescription group are established in experiment, and other establishes a low calcium matched group (150mg/100g feedstuff).30 rats were quarantined under laboratory condition after the week, be divided into three dosage groups at random, be respectively the control formula group, 1 group of research prescription, 2 groups of research prescriptions, 3 groups of research prescriptions, low calcium matched group, 10 every group, to be tried thing (corresponding prescription) and mix in the feedstuff and feed, by 10% conversion of body weight.Continuous 30 days.
1.4 observation index comprises that body weight and height mensuration are (behind the fasting 12h, measure body weight, height, 1 time weekly), the femur gravimetry (puts to death behind the animal feeding 30d, separate the right side femur, roasting to constant weight in 105 ℃ of baking boxs, weighing is key heavy), femoral bmd measure (bone density of measuring the fluff of femur mid point, distal end and sclerotin with dual intensity x light borne densitometers), calcium content of bone and feedstuff calcium content measure (use aas determination), rat growth promoter (birth ablactation rat all around after 1 week of laundering period, sub-cage rearing 30d.Drink deionized water to avoid from drinking-water, obtaining calcium.Measure height, body weight weekly once.Treatments of the sample: digest with bone calcium.Mensuration is carried out according to the step of atomic absorption spectrophotometer instrument description.Measure liquid, standard solution and blank and all use the lanthana solution dilution).
1.5 the statistical disposition data are carried out variance analysis with SPSS 10.0 software kits.
1.6 result
1.6.1 the variation of body weight and food utilization from table 1～2 as seen, each organizes body weight and food utilization index there was no significant difference between rat, shows that research prescription (prescription 1, prescription 2, prescription 3) does not have obvious influence to the weight of animals and food utilization.
Table 1 prescription is to the influence (n=10) of rat body weight
Table 2 prescription is to the influence (n=10) of rat food utilization
1.6.2 the mensuration of height as seen from Table 3,2nd, respectively filled a prescription in 3,4 weeks treated animal height and low calcium matched group relatively increases, and learns check by statistics, and difference has significance meaning (P＜0.05), long, each prescription group of the 1st all heights of beginning with hang down the calcium matched group relatively, difference does not have the significance meaning; Research prescription treated animal the 2nd, 3,4 all heights and control formula group relatively increase, and learn check by statistics, and difference has significance meaning (P＜0.05).
Table 3 prescription is to the influence (n=10) of rat height
Annotate: # represents and hangs down the calcium matched group relatively, P＜0.05; ★ represents to compare P＜0.05 with the control formula group.
1.6.3 the mensuration of femur weight, calcium content of bone as seen from Table 4, each fill a prescription treated animal right lateral thigh bone weight and low calcium matched group relatively increase, and learn check by statistics, and difference has significance meaning (P＜0.05); Each fill a prescription treated animal right lateral thigh calcium content of bone and low calcium matched group relatively increase, and learn check by statistics, and difference has significance meaning (P＜0.05); Research prescription group (prescription 1, prescription 2, prescription 3) animal femur weight and femur calcium content all are higher than the control formula group, learn check by statistics, and difference has significance meaning (P＜0.05).
Table 4 prescription is to the influence of femur weight, calcium content of bone
| Group | Dosage (g/kgbw) | Femur weight (g) | Calcium content of bone (g/kg) |
| Low calcium matched group | 0.00 | 0.35±0.02 | 103.5±6.8 |
| Control formula | 0.17 | 0.40±0.04# | 146.7±11.3# |
| Research prescription 1 | 0.58 | 0.49±0.04#★ | 169.8±15.5#★ |
| Research prescription 2 | 0.58 | 0.49±0.06#★ | 169.7±17.5#★ |
| Research prescription 3 | 0.58 | 0.49±0.05#★ | 169.8±13.5#★ |
| The F value | ? | 0.737 | 2.792 |
| The P value | ? | ＞0.05 | ＞0.05 |
Annotate: # represents and hangs down the calcium matched group relatively, P＜0.05; ★ represents to compare P＜0.05 with the control formula group.
1.6.4 the mensuration of bone density as seen from Table 5, the bone density and the low calcium matched group of the fluff of prescription treated animal left side femur mid point, distal end and sclerotin relatively increase, difference all has significance meaning (P＜0.05), research prescription group and control formula group relatively increase, and difference has significance meaning (P＜0.05).
Table 5 prescription is to the influence of bone density
Annotate: # represents and hangs down the calcium matched group relatively, P＜0.05; ★ represents to compare P＜0.05 with the control formula group.
1.7 conclusion: control formula and research prescription (prescription 1, prescription 2, prescription 3) all have positive acting to body length, femur weight, calcium content of bone and the bone density of rat, but the effect of research prescription (prescription 1, prescription 2, prescription 3) is better than control formula, and difference all has significance meaning (P＜0.05).
Embodiment 2 dose screenings
According to the prescription results of screening, selected research is filled a prescription as formula for a product, but need do further screening to the dosage of prescription.With the prescription among the embodiment 11 is example.
2.1 the experiment grouping experiment is established high, medium and low three dosage groups, dosage is respectively 0.29,0.58,1.74g/kg BW, is equivalent to 5,10,30 times of human body recommended amounts, and other establishes a low calcium matched group.Every group of 10 rats will be tried thing and mix in the feedstuff and feed 30 days observation periods.
2.2 observation index and detection method are with prescription screening part.
2.3 result
Credit is analysed by statistics, and each dosage group is compared with low calcium matched group, and each observation index all is better than low calcium matched group, and significant difference is arranged.Middle dosage group is compared with low dose group, and significant difference is arranged.High dose group and middle dosage group have significant difference than there was no significant difference with the low dose group ratio.
2.4 conclusion: compare with middle dosage group because of high dose group, the difference of each index does not have significance, and considers cost of material and the convenience of taking, and has therefore finally adopted middle dosage assembly side.
The check of embodiment 3 functional experiments
1, under this laboratory condition, show for the result of rat oral gavage after 3 months with this preparation (prescription 1 among the embodiment 1) of 0.29g/kgbw, 0.58g/kgbw, 1.74g/kgbw dosage: the height and the height value added in high dose group rat experiment latter stage are significantly higher than low calcium matched group; The bone density of high dose group rat femur center and distal end, femur weight, femur calcium content and TC are significantly greater than low calcium matched group; Basic, normal, high dosage group rat is taken in calcium and excrement calcium and middle and high dosage group rat urine calcium content and is significantly higher than low calcium matched group; The apparent absorbance of middle and high dosage group calcium in rats and the rate that retains significantly are lower than the calcium matched group.Difference has significance (P＜0.01 or P＜0.05).Above every index of high dose group rat does not have significance (p＞0.05) with corresponding calcium carbonate control group comparing difference.Point out the effect that this preparation has increases rat bone density.
2, result
2.1 this preparation (prescription 1) to the influence of rat body weight, the results are shown in Table 6.Organize respectively before the experiment that the inchoate aspect method of double differences of rat is different not to have a significance (P＞0.05); The weight increase value of each dosage group rat of experiment back is compared difference with low calcium matched group do not have significance (P＞0.05), and the end-body of high dose group rat weighs and has a net increase of the value added difference of comparing with calcium carbonate control group does not have significance (P＞0.05).
This preparation of table 6 is to the influence of rat body weight
2.2 this preparation (prescription 1) to the influence of rat height, the results are shown in Table 7.The initial height of respectively organizing rat before the experiment does not have significant difference (P＞0.05); Calcium carbonate control group, high dose group test last height and the height value added is significantly higher than low calcium matched group (P＜0.05 or P＜0.01); Experiment end height of high dose group rat and value added thereof are compared difference with calcium carbonate control group do not have significance (P＞0.05).
This preparation of table 7 is to the influence of rat height
2.3 this preparation (prescription 1) to the influence of rat femur length and bone density, the results are shown in Table 8.Each organizes the femur length difference of rat does not have significance (P＞0.05); Calcium carbonate control group, high dose group rat femur distal end bone density, femur center bone density are significantly higher than low calcium matched group (P＜0.05 or P＜0.01); Sample high dose group femur center bone density and femur distal end bone density are compared difference with calcium carbonate control group do not have significance (P＞0.05).
This preparation of table 8 is to the influence of rat femur length and bone density
2.4 this preparation (prescription 1) to the influence of rat femur weight and calcium content, the results are shown in Table 9.The femur weight of high dose group rat is significantly greater than low calcium matched group (P＜0.01), and the femur weight of high dose group rat is compared with corresponding calcium carbonate control group does not have significant difference (P＞0.05); Femur calcium content of high dose group rat and TC are significantly greater than low calcium matched group (P＜0.01).Femur calcium content of high dose group rat and TC are compared difference with corresponding calcium carbonate control group do not have significance (P＞0.05).
This preparation of table 9 is to the influence of rat femur weight, calcium content of bone and TC
TC=femur weight (g) * calcium content (mg/g)
2.5 the influence that this preparation (prescription 1) is taken in calcium, excrement calcium and urinated calcium rat the results are shown in Table 10.Each dosage group, calcium carbonate control group rat are taken in calcium and are significantly higher than low calcium matched group (P＜0.01), and the urine calcium content of basic, normal, high dosage group, calcium carbonate control group rat kind calcium and middle and high dosage group, calcium carbonate control group rat is significantly higher than low calcium matched group (P＜0.05 or P＜0.01); The absorption calcium of high dose group rat, excrement calcium and urine calcium output are compared difference with corresponding calcium carbonate control group do not have significance (P＞0.05).
This preparation of table 10 is to the influence of rat femur weight, calcium content of bone and TC
2.6 this preparation (prescription 1) retains the influence of rate to apparent absorbance of rat and calcium, the results are shown in Table 11.The apparent absorbance of middle and high dosage group, calcium carbonate control group calcium in rats significantly is lower than calcium matched group (P＜0.01).The apparent absorbance of high dose group calcium is compared difference with corresponding calcium carbonate control group do not have significance (P＞0.05); The rate that retains of middle and high dosage group calcium carbonate control group calcium in rats significantly is lower than calcium matched group (P＜0.01); The rate that retains of high dose group calcium is compared difference with corresponding calcium carbonate control group do not have significance (P＞0.05).
This preparation of table 11 is to the metabolic influence of calcium in rats
Apparent absorbance (%)=(taking in calcium-excrement calcium) taken in calcium * 100; Calcium retains rate (%)=(taking in calcium-excrement calcium-urine calcium)/absorption calcium * 100
2.7 adopt prescription 2 and prescription 3 to carry out the above-mentioned functions checking respectively, the result is similar to the result of the test that adopts prescription 1 to obtain.
3, brief summary
Under this laboratory condition, show for the result of rat oral gavage after 3 months with this preparation of 0.29g/kgbw, 0.58g/kgbw, 1.74g/kgbw dosage (prescription 1, prescription 2, prescription 3): the height and the height value added in high dose group rat experiment latter stage are significantly higher than low calcium matched group; The bone density of high dose group rat femur center and distal end, femur weight, femur calcium content and TC are significantly greater than low calcium matched group; Basic, normal, high dosage group rat is taken in calcium and excrement calcium and middle and high dosage group rat urine calcium content and is significantly higher than low calcium matched group; The apparent absorbance of middle and high dosage group calcium in rats and the rate that retains significantly are lower than the calcium matched group.Difference has significance (P＜0.01 or P＜0.05).Above every index of high dose group rat does not have significance (P＞0.05) with corresponding calcium carbonate control group comparing difference.Point out this preparation (prescription 1, prescription 2, prescription 3) to have the effect that increases rat bone density.
Therefore, skeleton of the present invention health care thing or pharmaceutical composition can bone density improving, alleviate bone pain, recover the bone function and improve immunity, and its advantage is: 1, effectively promote calcareous absorption; 2, repair the osteoarthrosis cell, promote the osteocyte growth; Obviously bone density improving is prevented and treated osteoporosis; 3, effectively promote skeleton collagen Proteometabolism, stabilization of bony collagen network structure, activation muscles and bones, anti-curing arthritis and aching; 4, recover osteoarthrosis proper motion function; 5, reduce the fracture occurrence risk; 6, human body immunity improving power; But 7 two-ways regulation human endocrine levels are improved the quality of living.
To sum up, skeleton health care thing of the present invention or pharmaceutical composition design ingenious uniqueness, take mutually between component together, the bioavailability height, can be used for bone density improving and alleviate bone pain and recover the bone function and improve immunity, obviously solve osteoporosis, bone pain, and symptom such as osteoarthrosis afunction, and can be made into compound preparation, have no side effect, be suitable for large-scale promotion application.
In this description, the present invention is described with reference to its certain embodiments.But, still can make various modifications and conversion obviously and not deviate from the spirit and scope of the present invention.Therefore, description is regarded in an illustrative, rather than a restrictive.
Claims (4)
1. skeleton health care thing or pharmaceutical composition is characterized in that, are made up of following materials based on weight: the calcium carbonate of 160000～185000 weight portions, the vitamin D of 1～2 weight portion
3, the phosphopeptide caseinate of 11000～13000 weight portions, the chondroitin sulfate of 30000～50000 weight portions, the glucosamine hydrochloride of 80000～100000 weight portions, the manganese chloride of the ossein of 50000～70000 weight portions and 1150～1500 weight portions.
2. skeleton health care thing according to claim 1 or pharmaceutical composition is characterized in that described calcium carbonate is 168000～180000 weight portions, described vitamin D
3It is 1～2 weight portion, described phosphopeptide caseinate is 11500～12500 weight portions, described chondroitin sulfate is 40000～50000 weight portions, described glucosamine hydrochloride be 88000～95000 weight portions with described ossein be 55000～65000 weight portions, the manganese chloride of 1200～1450 weight portions.
3. skeleton health care thing according to claim 1 or pharmaceutical composition is characterized in that described calcium carbonate is 173333 weight portions, described vitamin D
3Be 1 weight portion, described phosphopeptide caseinate is 12000 weight portions, and described chondroitin sulfate is 46667 weight portions, described glucosamine hydrochloride be 93333 weight portions with described ossein be 60000 weight portions, described manganese chloride is 1333 weight portions.
4. skeleton health care thing according to claim 1 or the application of pharmaceutical composition in preparation skeleton health product or medicine.
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