CN106605744A - Composition capable of reducing fat, slimming, expelling toxin and beautifying, as well as preparation method thereof - Google Patents
Composition capable of reducing fat, slimming, expelling toxin and beautifying, as well as preparation method thereof Download PDFInfo
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Abstract
The invention discloses a composition capable of reducing fat, slimming, expelling toxin and beautifying, as well as a preparation method thereof. The composition capable of reducing fat, slimming, expelling toxin and beautifying is prepared from the following raw materials: L-carnitine, a white kidney bean extract, a kudzuvine root extract, a green coffee bean extract, a garcinia cambogia extract, a cassia seed extract, and a lotus leaf extract. The preparation method of the composition comprises the following steps: stirring and mixing the raw materials according to pre-set proportion at room temperature, adding an excipient, carrying out stirring and mixing, preparing the mixture into tablets, capsules, granules, powder or oral liquid, carrying out sterilization, and carrying out packaging, so that the composition capable of reducing fat, slimming, expelling toxin and beautifying is prepared. The composition utilizes the L-carnitine to promote fat metabolism; moreover, multiple medicines are combined, and the essences thereof are absorbed. Thus, the composition is capable of regulating human hormone, conditioning endocrine, burning fat and eliminating toxins from the body so as to realize the effects of speeding up body metabolism, reducing fat, slimming, detoxifying and beautifying.
Description
Technical field
The present invention relates to field of health care food, specifically a kind of compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin and its preparation
Method.
Background technology
Obesity is a kind of metabolic syndrome of today's society generally existing.Developed country is become and developing country has faced
Most serious public health problem, it has collectively constituted four new great society difficult medical problems with acquired immune deficiency syndrome (AIDS), drug and alcohol abuse.Fertilizer
Fat disease prevalence is worldwide continuously increased, it is estimated that obese people counts to 2015 will be increased to by 1.36 hundred million in 2006
1.62 hundred million.Obesity is a kind of pathological state that body fat piles up excessive or abnormal distribution, obesity and type ii diabetes, coronary disease
The generation of the diseases such as disease, cancer, respiratory system disease and osteoarthritis is closely related.Therefore, prevention and treatment obesity becomes and subtracts
The key of the M ＆ M that few mankind increasingly increase.Strictly, obesity is disease of life-style, is exactly mainly
The disease of " eat come ", thus, it is one effectively and is most important approach from " diet " enforcement fat-reducing measure of starting with.
Motherland's medical science is early recognized to fat.Such as《Plain Questions is logical to comment deficiency and excess opinion》Say：" fertile high official, then the disease of fat meat and fine grain ",《Scape
Yue Quanshu》Say：" how it is anti-the deficiency of vital energyThe body of lid people, bone is monarch, and fertile people person is soft to be contained in just, excess of YIN in sun, and meat with
Blood has the deficiency of vital energy more into, total all cloudy class fertile people ", explicitly point out examine assign and diet be fat morbidity fundamental cause,《Dan Xi is controlled
The method heart will》In then clearly propose " how wet fertile white man is ", " fertile white man must excessive phlegm ".Therefore, Traditional Chinese medical theory thinks that obesity is expectorant
Accumulate in wet, due to visceral dysfunctions such as lung, spleen, kidney, liver and gall, and addiction Sorghum vulgare Pers. savoury, in lying on bed for a long time sitting, affection of exogenous damp etc.
Influencing each other for exopathogenic factor is caused.I.e. with insufficiency of the spleen, kidney deficiency, irritability stasis as this, expectorant, heat, wet, blood stasis, cream fat are mark, are " deficiency in origin
The disease of mark reality ".
Currently, many diet products it is many by " diuresis, rush down under, appetite-suppressing " with the characteristics of, body constitution is reduced while fat-reducing,
Spiritlessness and weakness, lassitude, hypoimmunity all day, or even there are certain additive, it is that one kind has nocuity unsound
Fat-reducing mode.And the satiety of slimmer can be substantially met, and and nutrition, the constitutional fat-reducing drink of balance can be supplemented
It is serious deficient.
The pharmacology and mechanism of action of pathology, clinical manifestation and slimming medicine therefore, according to obese people；Defer to Willie special
The principle and the traditional Chinese medical science " four gas five properties " of health diet pyramid is theoretical；Coordinate and there is lipid-loweringing, fat-reducing, strengthen physical ability and enriched nutritive
" integration of edible and medicinal herbs " food, collectively constituted can lipid-lowering weight-reducing, and can eliminating toxin and beautifying the skin, and conveniently, safely, have no side effect
Function compound recipe, meet " not anorexia, do not suffer from diarrhoea, not weak, not addiction " four fat-reducing principles.
The content of the invention
It is an object of the invention to provide a kind of compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin and preparation method thereof, to solve
The problem proposed in certainly above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme：
A kind of compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin, are prepared from by the raw material of following weight portion：L-carnitine
20～50 parts, 10～30 parts of Semen Phaseoli Vulgaris extract, 1～20 part of Radix Puerariae extract, 10～30 parts of green coffee bean extract, Fructus Resina garciniae
10～30 parts of extract, 5～20 parts of Semen Cassiae extract, 1～20 part of Folium Nelumbinis extract.
As further scheme of the invention：Further it is prepared from by the raw material of following weight portion：L-carnitine 20
～40 parts, 10～25 parts of Semen Phaseoli Vulgaris extract, 1～15 part of Radix Puerariae extract, 10～25 parts of green coffee bean extract, Fructus Resina garciniae is carried
Take 10～25 parts of thing, 5～15 parts of Semen Cassiae extract, 1～10 part of Folium Nelumbinis extract.
As further scheme of the invention：Further it is prepared from by the raw material of following weight portion：L-carnitine
30 parts, 15 parts of Semen Phaseoli Vulgaris extract, 10 parts of Radix Puerariae extract, 15 parts of green coffee bean extract, 15 parts of Resina garciniae berry extract, Semen Cassiae
10 parts of seed extract, 5 parts of Folium Nelumbinis extract.
A kind of each method processed of the described compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin, it is characterised in that by above-mentioned original
Material is stirred at room temperature mixing by preset proportioning, adds excipient, stirring mixing to make tablet, capsule, granule, powder
Or oral liquid, then sterilize, pack.
As further scheme of the invention：The excipient is starch, maltodextrin, resistant dextrin, Pulvis Talci, sucrose
One kind in powder, ethanol, Microcrystalline Cellulose, Lactose, hydroxypropyl methylcellulose sodium, inulin, oligofructose or magnesium stearate.
L-carnitine：L-carnitine (L-carnitine), is that one kind promotes fat also known as VBT or transliteration Carnitine
The amino acid of energy is converted into, red meat is the main source of L-carnitine, and human body is had no toxic side effect.It is different types of
Diet is containing the L-carnitine of 5-100 milligrams, but common people can only take in daily 50 milligrams from meals, vegetarian
Intake is less.The main Physiological Function of L-carnitine is to promote adipose conversion into energy, and taking L-carnitine can reduce body
While body fat, reduction body weight, moisture and muscle are not reduced, regarded as by International Obesity health tissues in 2003 most safe
The fat-reducing nutrient complementary goods having no side effect.
At present L-carnitine has been applied to the fields such as medicine, health care and food, and by Switzerland, France, the U.S. and the world
Health organization is defined as legal multipurpose nutritive agent.China's food additive sanitary standard GB2760-1996 defines left-handed
Carnitine tartrate is food enrichment, can be applicable to chewable tablet, drink, capsule, milk powder and milk beverage etc..
L-carnitine is a kind of crucial material in fat metabolic process, and fatty acid can be promoted to enter mitochondrial oxidation
Decompose.It may be said that carnitine is the carrier for transporting fatty acid.In long-time strenuous exercise, carnitine improves the oxygen of fat
Change speed, the consumption of glycogen is reduced, while also having delayed fatigue.At present people are applied to popular fat-reducing, sports carnitine
Athlete's fat reducing resisting fatigue, Jing is observed for many years, and effect is obvious.The Olympic Games in 1980, Italian endurance athletes generally take a left side
Rotation carnitine, achieves the achievement for attracting people's attention.Particularly nineteen eighty-two Italy football player takes L-carnitine and obtains the world
After cup champion, the L-carnitine just fashionable whole world becomes the new lover of nutritional supplement, and many high-tech weight-reducing products all make L-carnitine
One of main component for fat-reducing, suitably supplements L-carnitine, allows your fat to burn in time, and you can be allowed healthy, slender, possesses
Charming stature.
L-carnitine can remove unnecessary fat and other fat as the key substance of fatty acid beta oxidation in body
The residue of fat acid, is balanced intracellular energy.L-carnitine has been really achieved world health group in weight loss procedures
Knit the big standard of health slimming three of (WHO) defined：Not anorexia, do not suffer from diarrhoea, it is not weak.
The metabolic process of fat is sought to through an obstacle, and obstacle is exactly mitochondrial membrane, mitochondrion can with burn fat,
It is allowed to release energy, is consumed by body, but long-chain fatty acid can't pass this road obstacle, so carnitine is just served central
The effect of porter.Long-chain fatty acid is transported to bit by bit shielding outside, mitochondrion is given, its further oxidation is allowed.
L-carnitine is a kind of biostearin from red meats such as beef, Carnis Sus domesticas, and human body itself also can synthesize, and be
What is had now been found that subtracts the nutrient best and safe for left-handed fertilizer efficiency fruit.Due to being derived from food and human body itself
A part can be synthesized, not lose weight medicine and health product, so and having no side effect.1980：FDA (Food and Drug Adminstration)
(FDA) administrative manual publishes L-Carnitine for natural materials.
Obtain within 1993 the accreditation of U.S.'s food, drug administration (FDA) and World Health Organization (WHO) (WHO), US Experts committee
Member can confirm the safety of L-Carnitined, and German Ministry of Public Health regulation is using L-carnitine without the need for maximum.1996, in
The 16th national food additive technical committee for standardization (TCST) of state, it is allowed in beverage, milk beverage, cookiess, solid beverage, milk powder
Used in L-carnitine.
Semen Phaseoli Vulgaris extract：Sweet in the mouth is mild-natured, is one with warming the middle warmer and descending qi, only sharp the intestines and stomach, the function such as singultuss, kidney tonifying complement
Plant nourishing diet good food.Semen Phaseoli Vulgariss are rich in alpha-amylase inhibitor and dietary fiber.It can effectively block high starch food (rice
Meal, wheaten food, miscellaneous grain crops and related snacks and cake) in starch decomposition, the intake of the most of starch heat of blocking reduces human body most
Big is adipose-derived.Eat before the meal, 80% calorie intake (not affecting the absorption of other nutrient substance) can be blocked.Can be effective
Coordinate the Diet Therapy of slimmer, make their meals have enough, eliminate hunger sensation, and after the meal body weight does not increase.And in Semen Phaseoli Vulgariss elite
Alpha-amylase inhibitor Jing gastrointestinal tract is excreted, it is not necessary to through blood circulation, do not act on cerebral nerve maincenter, after eating not
Diarrhoea, not weak, anorexia, body weight do not rebound, comply fully with the fat-reducing principle of World Health Organization (WHO).
Radix Puerariae extract：(it is referred to as the isoflavone of phytoestrogen and different containing a large amount of highly active isoflavone in Radix Puerariae
Flavone inducer), with significant simulation, interference, two-ways regulation estrogen and progestogen to the undue stimulation of human body, can effectively mend
Fill and nurse one's health Endocrine Levels, accelerate internal metabolism, exclude toxin, enhance immunity, delay skin aging, so that skin
Skin has the gloss and elasticity of health, while fully producing heat, burn fat, the fat of accumulation is substantially slackened.And supplement
The trace element of needed by human body, adjusts physiological equilibrium, is allowed to not rebound, and reaches the effect of fat-reducing.
Semen Cassiae extract：Bitter in the mouth, sweet, salty, cold nature, enter liver, kidney, large intestine channel；Loosening bowel to relieve constipation, lipid-loweringing improving eyesight, treatment
Constipation and hyperlipidemia, hypertension.Liver heat removing and eyesight improving, diuretic relieving constipation has laxative action, reducing blood pressure and blood fat.
Green coffee bean extract：Green coffee is Rubiaceae evergreen shrubss or dungarunga, leaf opposite, keratin, long avette；Semen arachidis hypogaeae
In axil, white；Berry is oval, peony, two, built-in seed.Chlorogenic acid in green coffee bean extract is that plant exists
A kind of phenylpropanoids that Jing shikimic acid pathwaies are produced during aerobic respiration, are called caffeotannic acid, by various isomers
Constitute.Chlorogenic acid is soluble in water, ethanol, acetone, is slightly soluble in ethyl acetate, is in faint yellow solid under room temperature.Animal is external to grind
Study carefully proof, when the chlorogenic acid in green coffee reaches finite concentration, the hydrolysis that can irreversibly suppress G-6-Pase is made
With, reduce the decomposition of hepatic glycogen and reduce the absorption of Exogenous Glucose, promote human body to decompose body fat to supplement energy, to reach
To fat reducing effect.
Resina garciniae berry extract：HCA in Resina garciniae berry extract comes from natural extract, while and having Western medicine raw material clear and definite
Chemical composition and anti-obesity mechanism.It by suppress fat synthesis, promote fatty acid burning, reduce food intake, three
Position one, reaches the effect of slimming, and fat-reducing effect is fine, be a kind of Weight-reducing health raw material of health.The effect of HCA is former
Reason, exactly when human glucose switchs to fat, suppresses the ferment of one of ATP Citrate lyase, make fatty acid without
Method synthesizes, and suppresses the carrying out of sugar solution (glycolysis) effect.
Folium Nelumbinis extract：Property is pungent cool, and taste is slightly pained, micro- salty.It is various that Folium Nelumbinis contain nuciferine, miltanthin and nuciferine etc.
The compositions such as alkaloid and Flavonoid substances, vitamin, polysaccharide.Folium Nelumbinis have diuresis relieving constipation, logical intestinal poison, lipid-loweringing oil removing, clearing away summer-heat solution
Heat etc. is acted on, and can substantially reduce triglyceride and cholesterol level in serum, with the health-care effect for adjusting blood fat.Its fat-reducing is former
Reason be take after one layer of fatty isolating membrane is formed on human body intestinal wall, effectively prevent the absorption of fat, fundamentally loss of weight, and more
Effectively control bounce-back.Say in key to Diagnosis and Treatment：" Folium Nelumbinis take it, make us thin bad." visible Folium Nelumbinis are just found to have in ancient times fat-reducing
The effect of.There are Hedan tablet, XUEZHINING, ZHIMAIKANG JIAONANG, tablets for invigorating circulation and reducing bloodfat with Folium Nelumbinis taste, the Weight-reducing and lipid-lowering preparation as Main Ingredients and Appearance
Deng.(Sun Chenguang, by the fat-reducing and antihyperglycemic of Folium Nelumbinis, TCM clinical study 2014 (03), 100-103)
Compared with prior art, the invention has the beneficial effects as follows：
Compositionss with lipid-lowering weight-reducing waste-discharging and youth-keeping function of the present invention promote lipid metabolism with L-carnitine,
For principal agent；It is aided with the most of starch calorie intake of Semen Phaseoli Vulgaris extract blocking, green coffee bean extract reduces Exogenous Glucose
Absorb, Resina garciniae berry extract suppresses the synthesis of fat, Semen Cassiae extract diuretic relieving constipation；Assistant prevents fat from inhaling with Folium Nelumbinis extract
Receive, Radix Puerariae extract accelerates metabolism, excludes toxin.All medicines share, selects the essence, and it is in adjusting human hormone, nursing one's health
While secretion, burn fat excludes vivotoxin, and so as to reach human metabolism, lipid-loweringing, weight reducing, toxin expelling, skin care are accelerated
Effect.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than the embodiment of whole.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
Compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin, weigh respectively following raw materials：300 grams of L-carnitine, Semen Phaseoli Vulgaris are carried
Take 150 grams of thing, 100 grams of Radix Puerariae extract, 150 grams of green coffee bean extract, 150 grams of Resina garciniae berry extract, Semen Cassiae extract
100 grams, then 50 grams of Folium Nelumbinis extract, 600 grams of resistant dextrin mixes each raw material, stirs, and pours capsule filling into
In mould, fill capsule, subpackage obtains 3000,0.4 gram/.Wherein, per contains 0.075 gram of L-carnitine, and Semen Phaseoli Vulgaris are carried
Take 0.037 gram of thing, 0.037 gram of green coffee bean extract, 0.037 gram of Resina garciniae berry extract.
Embodiment 2
Compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin, weigh respectively following raw materials：300 grams of L-carnitine, Semen Phaseoli Vulgaris are carried
Take 150 grams of thing, 100 grams of Radix Puerariae extract, 150 grams of green coffee bean extract, 150 grams of Resina garciniae berry extract, Semen Cassiae extract
100 grams, then 50 grams of Folium Nelumbinis extract, 4000 grams of cane sugar powder mixes each raw material, stirs, using 50% ethanol
Used as binding agent, soft material processed will make granule in the oscillating granulator of the above-mentioned eye mesh screens of soft material Jing 14, granule be moved into multi-functional
In boiling drier, then 50 degrees Celsius of airpillow-dry about 30 minutes, control pellet moisture pelletizes 5%, and subpackage obtains 5000
Gram, 5 grams/bag.Wherein, per bag contains 0.3 gram of L-carnitine, 0.15 gram of Semen Phaseoli Vulgaris extract, 0.15 gram of green coffee bean extract, rattan
0.15 gram of yellow fruit extract.
Embodiment 3
Compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin, weigh respectively following raw materials：300 grams of L-carnitine, Semen Phaseoli Vulgaris are carried
Take 150 grams of thing, 100 grams of Radix Puerariae extract, 150 grams of green coffee bean extract, 150 grams of Resina garciniae berry extract, Semen Cassiae extract
100 grams, then 50 grams of Folium Nelumbinis extract, 1000 grams of Lactose, 200 grams of Microcrystalline Cellulose mixes each raw material, is sufficiently stirred for
Even, using 50% ethanol as binding agent, soft material processed will make granule in the oscillating granulator of the above-mentioned eye mesh screens of soft material Jing 14,
Granule is moved in multi-functional boiling drier, 50 degrees Celsius of airpillow-dry about 25 minutes, control pellet moisture 6%, granulation,
Then 100 grams of magnesium stearate is added in granule, total mixed, tabletting, film coating, subpackage obtains 5100,0.45 gram/piece.Its
In, per bag contains 0.058 gram of L-carnitine, and 0.029 gram of Semen Phaseoli Vulgaris extract, 0.029 gram of green coffee bean extract, Fructus Resina garciniae is extracted
0.029 gram of thing.
Embodiment 4
Compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin, weigh respectively following raw materials：300 grams of L-carnitine, Semen Phaseoli Vulgaris are carried
Take 150 grams of thing, 100 grams of Radix Puerariae extract, 200 grams of green coffee bean extract, 100 grams of Resina garciniae berry extract, Semen Cassiae extract
100 grams, then 50 grams of Folium Nelumbinis extract, 600 grams of resistant dextrin mixes each raw material, stirs, and pours capsule filling into
In mould, fill capsule, subpackage obtains 3000,0.4 gram/.Wherein, per contains 0.075 gram of L-carnitine, and Semen Phaseoli Vulgaris are carried
Take 0.037 gram of thing, 0.05 gram of green coffee bean extract, 0.025 gram of Resina garciniae berry extract.
Embodiment 5
Compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin, weigh respectively following raw materials：300 grams of L-carnitine, Semen Phaseoli Vulgaris are carried
Take 150 grams of thing, 100 grams of Radix Puerariae extract, 100 grams of green coffee bean extract, 200 grams of Resina garciniae berry extract, Semen Cassiae extract
100 grams, then 50 grams of Folium Nelumbinis extract, 600 grams of resistant dextrin mixes each raw material, stirs, and pours capsule filling into
In mould, fill capsule, subpackage obtains 3000,0.4 gram/.Wherein, per contains 0.075 gram of L-carnitine, and Semen Phaseoli Vulgaris are carried
Take 0.037 gram of thing, 0.025 gram of green coffee bean extract, 0.05 gram of Resina garciniae berry extract.
Embodiment 6
Compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin, weigh respectively following raw materials：300 grams of L-carnitine, Semen Phaseoli Vulgaris are carried
Take 200 grams of thing, 100 grams of Radix Puerariae extract, 100 grams of green coffee bean extract, 100 grams of Resina garciniae berry extract, Semen Cassiae extract
150 grams, then 50 grams of Folium Nelumbinis extract, 600 grams of resistant dextrin mixes each raw material, stirs, and pours capsule filling into
In mould, fill capsule, subpackage obtains 3000,0.4 gram/.Wherein, per contains 0.075 gram of L-carnitine, and Semen Phaseoli Vulgaris are carried
Take 0.05 gram of thing, 0.025 gram of green coffee bean extract, 0.025 gram of Resina garciniae berry extract.
Embodiment 7
Compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin, weigh respectively following raw materials：300 grams of L-carnitine, Semen Phaseoli Vulgaris are carried
Take 100 grams of thing, 100 grams of Radix Puerariae extract, 100 grams of green coffee bean extract, 100 grams of Resina garciniae berry extract, Semen Cassiae extract
200 grams, then 100 grams of Folium Nelumbinis extract, 600 grams of resistant dextrin mixes each raw material, stirs, and pours capsule into and fills out
In mold filling tool, fill capsule, subpackage obtains 3000,0.4 gram/.Wherein, per contains 0.075 gram of L-carnitine, Semen Phaseoli Vulgaris
0.025 gram of extract, 0.025 gram of green coffee bean extract, 0.025 gram of Resina garciniae berry extract.
Both effectiveness experimental verification：
First, animal experiment
1st, principle
This method is fat with high heat food induction animal, then gives given the test agent (obese model), or is giving height
Calorie food gives given the test agent (prevention obese model), observation the weight of animals, the change of body fat content simultaneously.
2nd, material and method
2.1 sample：Test specimen：Embodiment 1 obtains slimming capsule agent, gram/of specification 0.4.It is every that people orally recommends consumption
2 times a day for people (adult), 2 every time, and adult's body weight is calculated by 60KG, and equivalent dosage is prepared for 27mg/kg BW. with distilled water
Basic, normal, high dosage group is set into concentration with 5 times of human body recommended dose, 10 times, 20 times respectively.Pentobarbital sodium.Given the test agent is given
The time is given to be 7 weeks.
2.2 apparatuses and consumptive material：Gastric perfusion needle, syringe, animal balance, refrigerated centrifuger, dissecting instrument, spectrophotometer,
Test kit etc..
2.3 animals and feedstuff：SPF male SD rats, 200 ± 20g of body weight, every group of 8-12 is only.Animal room temperature：22-25
DEG C, relative humidity 55-75%；High heat model feedstuff：Add 15.0% sucrose, 15.0% Adeps Sus domestica in feedstuff is maintained, in right amount
Casein, calcium hydrogen phosphate, stone powder etc..It is the moisture of model feedstuff, crude protein, crude fat, crude fibre, thick in addition to crude fat
Ash, calcium, phosphorus, calcium：Phosphorus is intended to reach the national standard for maintaining feedstuff.
2.4 dosage choices give mode with tested material：According to the human body recommended dose of sample, if 133,266,533mg/kg
3 dosage groups of BW (being respectively equivalent to 5,10,20 times that human body recommends consumption).Separately set blank control group, an obese model pair
According to group and positive controls；Per group of 10 animals.It is divided into and weighs test specimen 1.33g, 2.66g, 5.33g, respectively adds distilled water extremely
100mL, mixes, be configured to 13.3,26.6, the suspension of 53.3mg/mL concentration, using oral mode, by 1.0mL/100g BW
Volume give corresponding dosage group animal gavage test solution, positive controls give orlistat (Xenical), Switzerland Ba Sai
Er Haofumai Roches company limited produces, and with distilled water the gavage liquid that concentration is 10mg/mL is configured to；Blank and model pair
Give isopyknic pure water according to group, daily gavage once, continuous gavage 6 weeks.
2.5 method
Obese model method
Laundering period：Rat feeding maintains feedstuff to observe 6 days under barrier system.
The modeling phase：
Laundering period is randomly divided into 2 groups after terminating by body weight, and 10 rats give maintenance feedstuff as blank control group, 60
Rat gives high heat model feedstuff.Record weekly to appetite, berley amount, surplus appetite, weigh in 1 time.
After feeding 2 weeks, give 60 rats of high-calorie feed and sort by weight gain, eliminate weight gain it is relatively low 1/
3 Diet resistant rats.High-calorie feed is given again 6 weeks, blank control group is given simultaneously by filter out 40 fat Sensitive Rats
Give maintenance feedstuff.
Given the test agent gives：
After the modeling phase terminates, 40 fat Sensitive Rats are randomly divided into 4 groups by body weight, respectively model control group and three
Dosage group.Record weekly to appetite, berley amount, surplus appetite, weigh in 1 time.Model control group and three dosage groups give height
Heat model feedstuff, blank control group gives maintenance feedstuff.Each dosage group gavage gives the given the test agent of various dose, model pair
The coordinative solvent of equivalent is given according to group and blank control group, given the test agent gave the time for 7 weeks.
After off-test, weigh, 1% pentobarbital sodium (0.5ml/100g BW) anesthesia, solution take perinephric fat,
Testis peripheral adipose, and weigh, calculate fat/body ratio.
2nd, data processing and result judgement
Typically statistical disposition is carried out to experimental data using variance analyses；The body weight or weight gain of experimental group is less than model
Matched group, body fat weight or fat/body ratio is less than model control group, and difference has significance, and food ration is not significantly lower than model
Matched group, can determine that the given the test agent animal weight losing function experimental result is positive.
3rd, experimental result
(1) impact of the slimming capsule to rat body weight
Each group rat body weight changes (X ± S) before and after table 1 is tested
* (P ＜ 0.01)；* (P ＜ 0.05)；## (P ＜ 0.01)；# (P ＞ 0.05)；
From table 1, compare with blank control group, model group rats body weight and body weight increase pole are significantly higher than blank
Group (P ＜ 0.01), illustrates modeling success；Compare with model control group, medication group rat body weight and body weight increase pole are substantially less than
Model group matched group (P ＜ 0.01), illustrates that Weight reducing compound has the effect of control body weight.
(2) impact of the slimming capsule to rat total foodstuff utilization rate
The weightening of each group rat of table 2, total food-intake and total foodstuff utilization rate (X ± S)
From table 2, positive controls, high dose group, total food-intake and total amount of heat of middle dosage combination low dose group are taken the photograph
Enter and be slightly less than model control group, but the difference beaten of each dosage group and model control group there are no significant (P ＞ 0.05).
(3) impact of the slimming capsule to rat body fat weight
The weight and fat/body weight proportion (X ± S) of each group rat body fat of table 3
From table 3, the rat limosis body weight of model control group, body fat weight and fat/body weight proportion are all higher than
Blank control group, difference has very significant (P ＜ 0.01), shows that obese model is set up.Positive controls and each dosage group
Rat limosis body weight, body fat weight and fat/body weight proportion be respectively less than model control group, and positive controls, height, in
The rat body fat weight of dosage group has very significant (P ＜ 0.01), positive controls with the difference of model control group
There is significance (P ＜ 0.05) with the rat fat/body weight proportion of high dose group and the difference of model control group, show the fat-reducing
Capsule has the effect that mitigation rat body fat is spreaded to.
Conclusion：Respectively with 133,266,533mg/kg BW (being respectively equivalent to 5,10,20 times that human body recommends consumption) dosage
Compositionss to obese model rat continuous gavage 6 weeks, the body weight increase of obese model rat can be suppressed, mitigate obese model big
The body fat of Mus is piled up, and reduces the food utilization of obese model rat, and the food ration and total amount of heat to animal is taken in without bright
Development rings, and these experimental result explanation said composition products have animal antiobesity action, and by difficult to understand with positive control drug sharp
Take charge of him to compare, fat-reducing effect is suitable.
4th, human feeding trial
1st, test method
Simple Obesity adult totally 250 is collected, one full year of life at age 30-60, random to divide 5 groups, per group of 50 people.
2nd, experimenter's inclusive criteria
Study subject is Simple Obesity crowd, BMI >=30 of being grown up, or total fat percentage reaches male ＞ 25%, female ＞
30% volunteer.
3rd, Subject Exclusion Criteria
Merge intentionally, liver, the serious disease such as kidney and hemopoietic system, psychotic.
The article relevant with tested function is taken in a short time, has influence on the judgement person to result.
Not by the edible given the test agent of regulation, it is impossible to which umbra does not ring effect or safety judgement person to judge effect or data.
5th, EXPERIMENTAL DESIGN and packet is required
The weight losing function test of staple food is not substituted
Designed using controlled trial between own control and group.Test-meal group is randomly divided into by the body weight of experimenter, body fat weight
And matched group, principal element such as age, sex, diet, the moving situation etc. for affecting result is considered as far as possible, carry out harmonious inspection
Test, to ensure the comparability between group.Every group of experimenter is no less than 50.
6th, the dosage and using method of given the test agent
The weight losing function given the test agent of staple food is not substituted：Test-meal group takes tested products by recommendation instructions of taking, dose,
Matched group can take placebo.Test-meal test is carried out by blind.Given the test agent gives the time 60 days.
7th, evaluation of result standard：
It is effective：15≤BMI ＜ 25
Take a turn for the better：25≤BMI ＜ 30
It is invalid：30≤BMI
The human experiment result statistical table of table 4 (total effective rate=obvious effective rate+improvement rate)
Result from table 4 can be seen that the fat-reducing effect of slimming capsule group of the present invention 1,2,3,4 preferably, greatly
It is better than placebo group greatly.Total effective rate is more than 88%.And without obvious side effect during taking.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of spirit or essential attributes without departing substantially from the present invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Claims (5)
1. a kind of compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin, it is characterised in that be prepared from by the raw material of following weight portion：
20～50 parts of L-carnitine, 10～30 parts of Semen Phaseoli Vulgaris extract, 1～20 part of Radix Puerariae extract, green coffee bean extract 10～30
Part, 10～30 parts of Resina garciniae berry extract, 5～20 parts of Semen Cassiae extract, 1～20 part of Folium Nelumbinis extract.
2. compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin according to claim 1, it is characterised in that it is further by with
The raw material of lower weight portion is prepared from：20～40 parts of L-carnitine, 10～25 parts of Semen Phaseoli Vulgaris extract, Radix Puerariae extract 1～15
Part, 10～25 parts of green coffee bean extract, 10～25 parts of Resina garciniae berry extract, 5～15 parts of Semen Cassiae extract, Folium Nelumbinis extract
1～10 part.
3. compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin according to claim 1 and 2, it is characterised in that further
It is prepared from by the raw material of following weight portion：30 parts of L-carnitine, 15 parts of Semen Phaseoli Vulgaris extract, 10 parts of Radix Puerariae extract, green coffee
15 parts of coffee bean extract, 15 parts of Resina garciniae berry extract, 10 parts of Semen Cassiae extract, 5 parts of Folium Nelumbinis extract.
4. a kind of preparation method of the compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin as described in any claim 1～3, it is special
Levy and be, above-mentioned raw materials are stirred at room temperature into mixing by preset proportioning, add excipient, stirring mixing to make tablet, glue
Capsule, granule, powder or oral liquid, then sterilize, packaging.
5. the preparation method of the compositionss with lipid-lowering weight-reducing eliminating toxin and beautifying the skin according to claim 4, it is characterised in that institute
Excipient is stated for starch, maltodextrin, resistant dextrin, Pulvis Talci, cane sugar powder, ethanol, Microcrystalline Cellulose, Lactose, hydroxypropyl
One kind in sodium cellulosate, inulin, oligofructose or magnesium stearate.
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| CN201610727018.0A CN106605744A (en) | 2016-08-25 | 2016-08-25 | Composition capable of reducing fat, slimming, expelling toxin and beautifying, as well as preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107440095A (en) * | 2017-08-03 | 2017-12-08 | 江西美庐乳业集团有限公司 | A kind of science loss of weight complete nourishing powder composition with satiety |
| CN108095068A (en) * | 2017-11-30 | 2018-06-01 | 北京东方红航天生物技术股份有限公司 | The food compositions and its application method of control body weight |
| CN109527575A (en) * | 2018-12-28 | 2019-03-29 | 李超 | A kind of lipid-loweringing is cultivated one's moral character toxin-expelling and face nourishing ferment |
| CN109567201A (en) * | 2019-01-04 | 2019-04-05 | 无锡海尔偲生命科技有限公司 | For blocking composition and the application of human body parts fat and carbohydrate absorption |
| CN109924485A (en) * | 2019-03-29 | 2019-06-25 | 华熙生物科技股份有限公司 | A kind of slimming health food and preparation method thereof containing hyaluronic acid |
| CN110574894A (en) * | 2018-06-11 | 2019-12-17 | 江苏帝尔生物科技有限公司 | nutritional meal replacement product capable of helping to eliminate vivotoxin and preparation method thereof |
| CN113170890A (en) * | 2021-05-25 | 2021-07-27 | 北京澳特舒尔保健品开发有限公司 | Fat-reducing and sugar-resisting health food composition and preparation method thereof |
| CN113397168A (en) * | 2021-06-29 | 2021-09-17 | 苏州赛迈尔生物科技有限公司 | Composition beneficial to weight management and preparation method thereof |
| CN114081087A (en) * | 2021-11-10 | 2022-02-25 | 湖南康琪壹佰生物科技有限公司 | Food for promoting fat metabolism of human body and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102150838A (en) * | 2010-12-16 | 2011-08-17 | 北京康比特体育科技股份有限公司 | Weight losing composition, preparation containing same and preparation method thereof |
| CN103891962A (en) * | 2014-04-16 | 2014-07-02 | 江苏安康生物科技发展有限公司 | Health tea capable of beautifying face and losing weight and preparation method of health tea |
| CN105146267A (en) * | 2015-08-24 | 2015-12-16 | 杭州娃哈哈科技有限公司 | Composition with weight losing function and application thereof |
| CN105341905A (en) * | 2015-10-27 | 2016-02-24 | 北京中科郎迈纳米科技有限公司 | Nutrient used for reducing weight and slimming |
-
2016
- 2016-08-25 CN CN201610727018.0A patent/CN106605744A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102150838A (en) * | 2010-12-16 | 2011-08-17 | 北京康比特体育科技股份有限公司 | Weight losing composition, preparation containing same and preparation method thereof |
| CN103891962A (en) * | 2014-04-16 | 2014-07-02 | 江苏安康生物科技发展有限公司 | Health tea capable of beautifying face and losing weight and preparation method of health tea |
| CN105146267A (en) * | 2015-08-24 | 2015-12-16 | 杭州娃哈哈科技有限公司 | Composition with weight losing function and application thereof |
| CN105341905A (en) * | 2015-10-27 | 2016-02-24 | 北京中科郎迈纳米科技有限公司 | Nutrient used for reducing weight and slimming |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107440095A (en) * | 2017-08-03 | 2017-12-08 | 江西美庐乳业集团有限公司 | A kind of science loss of weight complete nourishing powder composition with satiety |
| CN108095068A (en) * | 2017-11-30 | 2018-06-01 | 北京东方红航天生物技术股份有限公司 | The food compositions and its application method of control body weight |
| CN108095068B (en) * | 2017-11-30 | 2020-10-27 | 北京东方红航天生物技术股份有限公司 | Food composition for weight management and method of use thereof |
| CN110574894A (en) * | 2018-06-11 | 2019-12-17 | 江苏帝尔生物科技有限公司 | nutritional meal replacement product capable of helping to eliminate vivotoxin and preparation method thereof |
| CN109527575A (en) * | 2018-12-28 | 2019-03-29 | 李超 | A kind of lipid-loweringing is cultivated one's moral character toxin-expelling and face nourishing ferment |
| CN109567201A (en) * | 2019-01-04 | 2019-04-05 | 无锡海尔偲生命科技有限公司 | For blocking composition and the application of human body parts fat and carbohydrate absorption |
| CN109924485A (en) * | 2019-03-29 | 2019-06-25 | 华熙生物科技股份有限公司 | A kind of slimming health food and preparation method thereof containing hyaluronic acid |
| CN113170890A (en) * | 2021-05-25 | 2021-07-27 | 北京澳特舒尔保健品开发有限公司 | Fat-reducing and sugar-resisting health food composition and preparation method thereof |
| CN113397168A (en) * | 2021-06-29 | 2021-09-17 | 苏州赛迈尔生物科技有限公司 | Composition beneficial to weight management and preparation method thereof |
| CN114081087A (en) * | 2021-11-10 | 2022-02-25 | 湖南康琪壹佰生物科技有限公司 | Food for promoting fat metabolism of human body and preparation method thereof |
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