CN107582738A - A kind of Chinese medicine for losing weight composition and preparation method thereof - Google Patents
A kind of Chinese medicine for losing weight composition and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine for losing weight composition, said composition includes following raw material：5 25 parts of gynostemma pentaphylla, 2 22 parts of cassia seed, 3 10 parts of radish seed (stir-fry), 5 20 parts of fructus cannabis, 28 parts of citrus chachiensis hortorum, 5 20 parts of Poria cocos, 2 10 parts of lotus leaf, 3 15 parts of Chinese Fevervine Herb, 16 parts of green tea.The invention also discloses the preparation method of said composition.The present composition by sending down abnormally ascending arrange it is turbid, relax bowel, helping digestion disperse accumulations so as to reach fat-reducing disappear fat the effect of.The present invention it is raw materials used for " integration of drinking and medicinal herbs " class Chinese medicine, the Chinese herbal medicine of the Chinese medicine of raw material available for health food, daily drunk tealeaves or the raw material as characteristic snack among the people, each flavour of a drug pass through scientific and reasonable formula, prescription is rigorous, the few power of medicine is special, with nutrition and treatment two-way function, fat-reducing effect is obvious, the advantages that safe without toxic side effect.
Description
Technical field
The invention belongs to medicine field, and in particular to a kind of Chinese medicine for losing weight composition and preparation method thereof.
Background technology
With the continuous development of science and technology and society, people's living standard is steadily improved, and overweight and problem of obesity are also got over
It is fat as one of chronic disease of world today's most serious more to protrude, it is referred to as global prevalence disease.In the world,
The adult and 10% children for having more than 1,000,000,000 belong to overweight and fat；In China, population obesity rates are 12%, it has also become the world
The most populous country of upper obesity.Obesity is the result of heredity, psychology, social economy and the interaction of culture background factors,
Existing inherent cause (constituting about 25-40%), there is very strong environmental factor again.With the continuous improvement of people's living standards,
Quick rhythm of life causes pressure to increase, and bad eating habit, such as high fat savoury, excessive drinking and smoking, in addition, most of
Working clan is chronically at the state of sitting, does not get enough athletic exercise, and the incidence of disease for causing obesity is in tend to rise situation year by year.Fat band
To people definitely be not only stature aesthetic the problem of, obesity also trigger a series of health problems, obesity can be led
Cause many relevant diseases, such as type II diabetes, cardiovascular disease, gallbladder disease, osteoarthritis, obstructive sleep apnea and
Other cancers.The Major Risk Factors of obesity or many serious diseases, add hypertension, diabetes, blood fat disorder,
The morbidity and mortality of the diseases such as coronary heart disease, malignant tumour, turn into the sixth-largest disease risk factors in the whole world.In addition, fat
Generation result in medical expense increase, and serious health problem, psychological problems and financial burden are brought to society and individual.Cause
This, problem of obesity becomes the focus of global concern, and fat preventing and treating is extremely urgent.
Method of weight-reducing is mainly kept on a diet, kept fit through sport, gastrointestinal surgery, gene therapy, drug therapy, its Chinese medicine
Thing treatment is most convenient, most popular supplementary means.At present there is offer limited effectiveness or bad anti-in the slimming drugs of commercial type
The defects of serious is answered, the problem of different degrees of or hidden danger in security be present, such as causing enterogastric diseases, arrythmias, head
Bitterly, angiocardiopathy, habituation etc. endanger, and incorrect use results even in death, these dangerous presence, also limit this
The use range of a little slimming medicines.In addition, easily bounce-back, and current the shortcomings that slimming drugs are commonly present on the market.Therefore seek
The slimming drugs that curative for effect, toxic side effect is small, is not easy to rebound are looked for turn into the important topic of the world of medicine of various countries growing interest.The traditional Chinese medical science
Medicine has rich experience in terms of obesity is prevented and treated, and its purpose is not only limited to treatment obesity itself, and is additionally beneficial to one
The preventing and treating of serious complications, and Chinese medicine possesses low cost, Small side effects, can be long-term use of the features such as.
The present invention works out a kind of Chinese medicine for losing weight composition, is made up of the taste Chinese medicine of gynostemma pentaphylla etc. 8, wherein cassia seed, Lay clothes
Son, fructus cannabis, Poria cocos, lotus leaf are " integration of drinking and medicinal herbs class " Chinese medicine, and gynostemma pentaphylla is that the Ministry of Public Health announces for 2002《On further rule
The notice of model healthy food material management》In can be used for the article list of health food, citrus chachiensis hortorum both be Chinese medicine, again to be traditional
Spices and season good taste, can medicine-food two-purpose, Chinese Fevervine Herb is the raw material of Guangdong and Guangxi Provinces characteristic snack among the people, and green tea is is daily drunk by people
Tealeaves.The Chinese medicine composition has the two-way function of nutrition and treatment, has Mutiple Targets adjustment effect during for losing weight, safety
Effectively, relevant report is had not yet to see.
(1) gynostemma pentaphylla, it is the complete of cucurbitaceous plant gynostemma pentaphylla Gynostemma pentaphyllum (Thunb.) Mak.
Grass.Record in《Chinese book on Chinese herbal medicine》：【Nature and flavor and channel tropism】Hardship, it is sweet, it is cool；Returns spleen, lung, kidney channel.【Function is with curing mainly】Heat-clearing；Qi-restoratives；
Removing toxic substances.For physically weak weak, nephrasthenia emission, hyperlipidemia, virus hepatitis, chronic gastroenteritis, chronic bronchitis.
(2) cassia seed, it is legume Cassia Cassia obtusifolia L.'s or little Cassia tora Cassia tora L.
Dry mature seed.Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is sweet, bitter, salty, it is slightly cold；Return liver, large intestine channel.
【Function is with curing mainly】Heat-clearing improving eyesight, relax bowel.Secretly fail to understand for the puckery pain of hot eyes, the more tears of photophobia, dizziness of having a headache, mesh, big constipation
Knot.
(3) radish seed, it is crucifer radish Raphanus sativusL. dry mature seed.Record in《In
State's pharmacopeia》Version in 2015：【Nature and flavor and channel tropism】It is pungent, sweet, put down；Return lung, spleen, stomach.【Function is with curing mainly】Help digestion de-swelling, sending down abnormally ascending
Phlegm.For retention of food and drink, abdominal distention, constipation, stagnate rush down dysentery, and phlegm, which is stopped up, breathes with cough.
(4) fructus cannabis, it is moraceae plants hemp Cannabis sativa L. dry mature fruit.Record in《China
Pharmacopeia》Version in 2015：【Nature and flavor and channel tropism】It is sweet, put down；Returns spleen, stomach, large intestine channel.【Function is with curing mainly】Relax bowel.For the deficiency of blood
Body fluid deficiency, dry constipation of intestines.
(5) citrus chachiensis hortorum, the dried orange peel produced by Guangdong.Dried orange peel is rutaceae orange Citrus reticulata Blanco
And its dry mature skin of variety.Dried orange peel record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is bitter, pungent, temperature；
Return lung, the spleen channel.【Function is with curing mainly】Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.For abdominal fullness and distention, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
(6) Poria cocos, it is On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf dry sclerotia.Record in《In
State's pharmacopeia》Version in 2015：【Nature and flavor and channel tropism】It is flat, it is sweet, light；The thoughts of returning home, lung, spleen, kidney channel.【Function is with curing mainly】Clearing damp and promoting diuresis, it is good for
Spleen calming heart.For oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
(7) lotus leaf, it is nymphaeaceae plant lotus Nelumbo nucifera Gaertn. dried leaf.Record in《Middle traditional Chinese medicines
Allusion quotation》Version in 2015：【Nature and flavor and channel tropism】Hardship, put down；Return liver, spleen, stomach.【Function is with curing mainly】Clearing away summer-heat and eliminating dampness, sending up the lucid yang, cool blood
Hemostasis.Mandrill, uterine bleeding of having blood in stool are told for hot summer weather polydipsia, summer heat damp diarrhea, splenasthenic diarrhea, blood-head.
(8) Chinese Fevervine Herb, it is the herb and root of madder wort Chinese Fevervine Herb.Record in《Dictionary of medicinal plant》：【Nature and flavor are with returning
Through】Sweet acid, put down；The heart, liver, spleen, kidney channel.【Function is with curing mainly】Dispelling wind and eliminating dampness, promoting digestion and removing indigestion, removing toxicity for detumescence, promoting blood circulation and stopping pain.For
Arthralgia pain due to rheumatism, dyspeptic abdominal distention, infantile malnutrition, diarrhoea, acute appendicitis.Raw material of this product also as local characteristic snack are in south China
It is widely adopted.
The disclosure of background above technology contents is only used for inventive concept and the technical scheme that auxiliary understands the present invention, and it is not
The prior art of present patent application is necessarily belonged to, shows the applying date of the above in present patent application in no tangible proof
In the case of disclosed, above-mentioned background technology should not be taken to evaluate the novelty and creativeness of the application.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine for losing weight composition and preparation method thereof, to solve to deposit in the prior art
Diet products toxic side effect it is big, fat-reducing effect is bad, easily rebound the problems such as.It is each used in the Chinese medicine for losing weight composition of the present invention
Flavour of a drug are by scientific and reasonable formula, and prescription is rigorous, and the few power of medicine is special, and fat-reducing effect is obvious, has no toxic side effect.
To solve the above problems, the technical solution adopted by the present invention is as follows：
A kind of Chinese medicine for losing weight composition, including following raw material：Gynostemma pentaphylla 5-25 parts, cassia seed 2-22 parts, radish
Son (stir-fry) 3-10 parts, fructus cannabis 5-20 parts, citrus chachiensis hortorum 2-8 parts, Poria cocos 5-20 parts, lotus leaf 2-10 parts, Chinese Fevervine Herb 3-15 parts, green tea
1-6 parts.
Above-described Chinese medicine for losing weight composition, most preferably preferably includes following raw material：15 parts of gynostemma pentaphylla, cassia seed
12 parts, 6 parts of radish seed (stir-fry), 12 parts of fructus cannabis, 5 parts of citrus chachiensis hortorum, 12 parts of Poria cocos, 7 parts of lotus leaf, 8 parts of Chinese Fevervine Herb, 3 parts of green tea.
Above-described Chinese medicine for losing weight composition, can be prepared into medicinal tea, capsule, pill, tablet, granule etc., preferably
Medicinal tea, capsule is made.
Chinese medicine for losing weight composition described in more than one is prepared into the preparation method of medicinal tea, comprises the following steps：
S1. gynostemma pentaphylla, cassia seed, radish seed (stir-fry), fructus cannabis, citrus chachiensis hortorum, Poria cocos, lotus leaf, Chinese Fevervine Herb, green is taken respectively
Tea, clean, clean, dry；
S2. weighed by following parts by weight：Gynostemma pentaphylla 5-25 parts, cassia seed 2-22 parts, radish seed (stir-fry) 3-10 parts, fructus cannabis
5-20 parts, citrus chachiensis hortorum 2-8 parts, Poria cocos 5-20 parts, lotus leaf 2-10 parts, Chinese Fevervine Herb 3-15 parts, green tea 1-6 parts；
S3. load weighted Chinese medicine is crushed, crosses 40-100 mesh sieves；
S4. mix, pack, seal, sterilizing, mechanical packaging, produce.
Chinese medicine for losing weight composition described in more than one is prepared into the preparation method of capsule, comprises the following steps：
R1. gynostemma pentaphylla, cassia seed, radish seed (stir-fry), fructus cannabis, citrus chachiensis hortorum, Poria cocos, lotus leaf, Chinese Fevervine Herb, green is taken respectively
Tea, clean, clean, dry；
R2. weighed by following parts by weight：Gynostemma pentaphylla 5-25 parts, cassia seed 2-22 parts, radish seed (stir-fry) 3-10 parts, fructus cannabis
5-20 parts, citrus chachiensis hortorum 2-8 parts, Poria cocos 5-20 parts, lotus leaf 2-10 parts, Chinese Fevervine Herb 3-15 parts, green tea 1-6 parts；
R3. load weighted medicinal material is added water to cook, filters, obtain filtrate；
R4. thick paste is concentrated the filtrate to, dry, pulverize, is sieved, get dry extract fine powder；
R5. dry cream fine powder is taken, adds filler and lubricant, is mixed, loads capsule, produces.
Further, above-described Chinese medicine for losing weight composition is prepared into the preparation method of capsule, is decocted described in step R3
Boil to add water to cook 2 times, for the first time plus 2-3 hours are boiled in the 10-15 times of decocting measured, and for the second time plus 1-2 is boiled in the 5-10 times of decocting measured
Hour.
Further, above-described Chinese medicine for losing weight composition is prepared into the preparation method of capsule, thick described in step R4
The relative density of cream is 1.03-1.05 at 70 DEG C, and the drying temperature is 60-70 DEG C, drying time 6-8h；The sieving is
Cross 100-120 mesh sieves.
Further, above-described Chinese medicine for losing weight composition is prepared into the preparation method of capsule, is filled out described in step R5
Fill agent for one or more kinds of combinations in starch, microcrystalline cellulose, lactose and dextrin, the lubricant be magnesium stearate,
One or more kinds of combinations in talcum powder and silica.
Compared with prior art, beneficial effects of the present invention are as follows：
1. in the prescription of the present invention, with gynostemma pentaphylla heat-clearing, qi-restoratives, removing toxic substances；Cassia seed leads to cloudy Liver Channel, relaxes bowel, disperse accumulations
Lead stagnant, Li Shui；Lotus leaf helps spleen health movement, sending up the lucid yang；Radish seed, fructus cannabis, Chinese Fevervine Herb and Poria cocos sending down abnormally ascending row are turbid, can exclude in time
Internal and enteron aisle rubbish；Citrus chachiensis hortorum regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm；Above-mentioned composition shares and plays the logical tune of reinforcing and reducing methods altogether, invigorating the spleen helps fortune, changed
Wet eliminating phlegm, the work(being healthy and strong of making light of one's life by commiting suicide, will accumulate in internal metabolic waste and toxin excludes, and treatment is fat on the whole.
2. the present invention it is raw materials used for " integration of drinking and medicinal herbs " class Chinese medicine, available for health food raw material Chinese medicine, daily drink
The Chinese herbal medicine of tealeaves or raw material as characteristic snack among the people, each flavour of a drug are by scientific and reasonable formula, and prescription is rigorous, and medicine is few
Power is special, has nutrition and treatment two-way function, and fat-reducing effect is obvious, and the advantages that safe without toxic side effect, fat-reducing effective percentage is up to
More than 90%.
3. the Chinese medicine for losing weight composition of the present invention does not have to go on a diet during taking, without suffering from hunger or even suffer all kinds of suffering from diarrhoea it
Hardship, gently not stimulating intestine and stomach, and be not easy to rebound is economical and practical, is easy to be received by Weight loss group.
Embodiment
With reference to specific embodiment, the invention will be further described, but does not limit the scope of the invention and apply
Scope：
First, Chinese medicine for losing weight composition is prepared into medicinal tea
Embodiment 1
A kind of Chinese medicine for losing weight composition is prepared into the preparation method of medicinal tea, comprises the following steps：
S1. gynostemma pentaphylla, cassia seed, radish seed (stir-fry), fructus cannabis, citrus chachiensis hortorum, Poria cocos, lotus leaf, Chinese Fevervine Herb, green is taken respectively
Tea, clean, clean, dry；
S2. weighed by following parts by weight：Gynostemma pentaphylla 0.5kg, cassia seed 0.2kg, radish seed (stir-fry) 0.3kg, fructus cannabis
0.5kg, citrus chachiensis hortorum 0.2kg, Poria cocos 0.5kg, lotus leaf 0.2kg, Chinese Fevervine Herb 0.3kg, green tea 0.1kg；
S3. load weighted Chinese medicine is crushed, crosses 100 mesh sieves；
S4. mix, pack, seal, sterilizing, mechanical packaging, produce.
Embodiment 2
A kind of Chinese medicine for losing weight composition is prepared into the preparation method of medicinal tea, comprises the following steps：
S1. gynostemma pentaphylla, cassia seed, radish seed (stir-fry), fructus cannabis, citrus chachiensis hortorum, Poria cocos, lotus leaf, Chinese Fevervine Herb, green is taken respectively
Tea, clean, clean, dry；
S2. weighed by following parts by weight：Gynostemma pentaphylla 2.5kg, cassia seed 2.2kg, radish seed (stir-fry) 1.0kg, fructus cannabis
2.0kg, citrus chachiensis hortorum 0.8kg, Poria cocos 2.0kg, lotus leaf 1.0kg, Chinese Fevervine Herb 1.5kg, green tea 0.6kg；
S3. load weighted Chinese medicine is crushed, crosses 40 mesh sieves；
S4. mix, pack, seal, sterilizing, mechanical packaging, produce.
Embodiment 3
A kind of Chinese medicine for losing weight composition is prepared into the preparation method of medicinal tea, comprises the following steps：
S1. gynostemma pentaphylla, cassia seed, radish seed (stir-fry), fructus cannabis, citrus chachiensis hortorum, Poria cocos, lotus leaf, Chinese Fevervine Herb, green is taken respectively
Tea, clean, clean, dry；
S2. weighed by following parts by weight：Gynostemma pentaphylla 1.5kg, cassia seed 1.2kg, radish seed (stir-fry) 0.6kg, fructus cannabis
1.2kg, citrus chachiensis hortorum 0.5kg, Poria cocos 1.2kg, lotus leaf 0.7kg, Chinese Fevervine Herb 0.8kg, green tea 0.3kg；
S3. load weighted Chinese medicine is crushed, crosses 70 mesh sieves；
S4. mix, pack, seal, sterilizing, mechanical packaging, produce.
2nd, Chinese medicine for losing weight composition is prepared into capsule
Embodiment 4
A kind of Chinese medicine for losing weight composition is prepared into the preparation method of capsule, comprises the following steps：
R1. gynostemma pentaphylla, cassia seed, radish seed (stir-fry), fructus cannabis, citrus chachiensis hortorum, Poria cocos, lotus leaf, Chinese Fevervine Herb, green is taken respectively
Tea, clean, clean, dry；
R2. weighed by following parts by weight：Gynostemma pentaphylla 25kg, cassia seed 22kg, radish seed (stir-fry) 10kg, fructus cannabis 20kg,
Citrus chachiensis hortorum 8kg, Poria cocos 20kg, lotus leaf 10kg, Chinese Fevervine Herb 15kg, green tea 6kg；
R3. load weighted medicinal material is added water to cook 2 times, for the first time plus 15 times of decoctings measured are boiled 3 hours, second plus 10 times
The decocting of amount is boiled 1 hour, filtering, obtains filtrate；
R4. relative density is concentrated the filtrate in the thick paste that 70 DEG C are 1.05,70 DEG C of drying 6 hours, is crushed, 100 mesh of mistake
Sieve, get dry extract fine powder；
R5. dry cream fine powder is taken, adds starch, microcrystalline cellulose, lactose and magnesium stearate, is mixed, loads capsule, produces.
Embodiment 5
A kind of Chinese medicine for losing weight composition is prepared into the preparation method of capsule, comprises the following steps：
R1. gynostemma pentaphylla, cassia seed, radish seed (stir-fry), fructus cannabis, citrus chachiensis hortorum, Poria cocos, lotus leaf, Chinese Fevervine Herb, green is taken respectively
Tea, clean, clean, dry；
R2. weighed by following parts by weight：It is gynostemma pentaphylla 15kg, cassia seed 12kg, radish seed (stir-fry) 6kg, fructus cannabis 12kg, wide
Dried orange peel 5kg, Poria cocos 12kg, lotus leaf 7kg, Chinese Fevervine Herb 8kg, green tea 3kg；
R3. load weighted medicinal material is added water to cook 2 times, for the first time plus 12 times of decoctings measured are boiled 2.5 hours, second plus 8
The decocting of amount is boiled 1.5 hours again, is filtered, is obtained filtrate；
R4. relative density is concentrated the filtrate in the thick paste that 70 DEG C are 1.04,65 DEG C of drying 7 hours, is crushed, 110 mesh of mistake
Sieve, get dry extract fine powder；
R5. dry cream fine powder is taken, adds microcrystalline cellulose, dextrin, talcum powder and silica, is mixed, loads capsule, i.e.,
.
Embodiment 6
A kind of Chinese medicine for losing weight composition is prepared into the preparation method of capsule, comprises the following steps：
R1. gynostemma pentaphylla, cassia seed, radish seed (stir-fry), fructus cannabis, citrus chachiensis hortorum, Poria cocos, lotus leaf, Chinese Fevervine Herb, green is taken respectively
Tea, clean, clean, dry；
R2. weighed by following parts by weight：It is gynostemma pentaphylla 5kg, cassia seed 2kg, radish seed (stir-fry) 3kg, fructus cannabis 5kg, wide old
Skin 2kg, Poria cocos 5kg, lotus leaf 2kg, Chinese Fevervine Herb 3kg, green tea 1kg；
R3. load weighted medicinal material is added water to cook 2 times, for the first time plus 10 times of decoctings measured are boiled 2 hours, second plus 5 times
The decocting of amount is boiled 2 hours, filtering, obtains filtrate；
R4. relative density is concentrated the filtrate in the thick paste that 70 DEG C are 1.03,60 DEG C of drying 8 hours, is crushed, 120 mesh of mistake
Sieve, get dry extract fine powder；
R5. dry cream fine powder is taken, adds starch, magnesium stearate and talcum powder, is mixed, loads capsule, produces.
3rd, animal experiment
According to the Ministry of Public Health《Health food is examined and assessment technique specification (version in 2003)》Carry out animal function test and examination
Test evaluation of result.
1. test principle：Using obese model method, animal obesity is induced with high heat food, then give given the test agent (fertilizer
Fat model), observe the change of the weight of animals, body fat content.
2. test material
2.1 sample
Using the product of the embodiment of the present invention 5 as given the test agent, while with commercially available orlistat capsule (Western medicine), slimming capsule
(Chinese medicine) is positive control.
2.2 experimental animal
From SD male rats, body weight 140-160g.
2.3 key instrument
Animal balance, disscting instrument.
2.4 nutrient fodder formulas：Basal feed 80%, lard 10%, yolk powder 10%.
3. test method
Using obese model method.
The foundation of 3.1 experimental animal obese models
70 male rats are randomly divided into 2 groups：One group is blank control group, 10, feeds basal feed daily；One group is to make
Module, 50, nutrient fodder is fed daily, two groups of daily diet of rat are identical, free water, feed 45 days, during which claim body weekly
Weigh 1 time, calculate food utilization.
3.2 animal packets and medication
After modeling 45 days, successful 60 obese rats of modeling are randomly divided into 5 groups, respectively model control group, the positive
Control group 1 (Western medicine), positive controls 2 (Chinese medicine), the basic, normal, high dosage group of the product of the embodiment of the present invention 5, every group 10.Low,
Middle and high dosage group, the embodiment of the present invention 5 product content thing 0.25g/kg.d, 0.5g/kg.d, 1.0g/kg.d are given respectively and (is divided
5,10,20 times of the recommended amounts that Wei not be grown up) gavage, positive controls 1 (Western medicine), give profit and take charge of his 0.06g/kg.d gavages, sun
Property control group 2 (Chinese medicine), gives slimming capsule content 0.6g/kg.d gavages；Blank control group, model control group, which are given, distills
Water, gavage volume are 20ml/kg.d, are administered once/d, continuous 30d.
3.3 Testing index and method
3.3.1 food ration, food utilization
Record food ration daily, claim a weight weekly, calculate food utilization.
3.3.2 fat mass, fat body ratio
Solution takes kidney and the fat of surrounding genital weighs fat mass, calculates fat body ratio.
4. result
The foundation of 4.1 obese rat models
After modeling 45 days, compared with blank control group, modeling group weight and food utilization significantly raise after modeling
(P ＜ 0.05), show that obese rat model is successfully established, be shown in Table 1.
Rat changes of body mass after the modeling of table 1
Note:Compared with blank control group,#P ＜ 0.05,##P ＜ 0.01
The influence of 4.2 pairs of obese rat weights
Compared with model control group, positive controls 1 (Western medicine), positive controls 2 (Chinese medicine) and the present invention after administration
The middle and high dosage group weight of embodiment 5 significantly reduces (P ＜ 0.05 or P ＜ 0.01), show the product of the embodiment of the present invention 5 with
Two control medicines increase to obese rat weight inhibitory action, is shown in Table 2.
Table 2 to obese rat weight influence (N=10)
Note：Compared with blank control group,#P ＜ 0.05；Compared with model group,*P ＜ 0.05,**P ＜ 0.01
The influence of 4.3 pairs of food rations and food utilization
The product of the embodiment of the present invention 5 basic, normal, high dosage group rat food ration, food utilization and model comparison after administration
Group compares no significant difference (P ＞ 0.05), and two positive controls rat food rations, food utilizations are compared with model control group
There is significant difference, be shown in Table 3.
Table 3 to obese rat food utilization influence (N=10)
Note：Compared with blank control group,#P ＜ 0.05；Compared with model control group,*P ＜ 0.05
4.4 pairs of fat masses and fat body than influence
Compared with model control group, the basic, normal, high dosage group of the product of the embodiment of the present invention 5 and two positive controls fat
Fat quality, fat body ratio significantly reduce (P ＜ 0.05 or P ＜ 0.01), show that the product of the embodiment of the present invention 5 and two positives are right
The accumulation of body fat can be reduced according to medicine, fat body ratio is reduced, is shown in Table 4.
Table 4 to obese rat fat mass, fat body than influence (N=10)
Note：Compared with blank control group,#P ＜ 0.05；Compared with model control group,*P ＜ 0.05,**P ＜ 0.01
4th, clinical practice is tested
1. case selection standard
With reference to 2003《Chinese Adult is overweight and obesity prevention and control guide (on probation)》According to body mass index method BMI
(kg/m2)=body weight (kg)/[height (m)]2.BMI is the diagnosis most important index of obesity.Overweight BMI=24~29.9, gently
Degree is fat；BMI=30~34.9, central obesity；BMI=35~39.9, severe simple obesity；BMI >=40, male's waistline are more than or equal to
85cm and women waistline are Central obesity more than or equal to 80cm.
2. therapeutic scheme
The obesity patient 304 of above-mentioned standard will be met, wherein man 159, female 145, severe simple obesity 147, in
Degree is fat 125, Mild Obesity 24, overweight 8, is randomly divided into 8 groups, every group 38.
Embodiment group：Give oral 1-6 of embodiment of the present invention samples, wherein embodiment 1-3 samples, once a bag, one day 3
It is secondary, taken after being soaked 10 minutes with 300ml boiling water；Embodiment 4-6 products, one time 3, three times a day.Continuously take 30 days.
Control group 1 (Western medicine)：Commercially available orlistat capsule is given, by specification is taken.Continuously take 30 days.
Control group 2 (Chinese medicine)：Commercially available slimming capsule is given, by specification is taken.Continuously take 30 days.
3. efficacy evaluation
It is effective：Body weight loss >=5kg in 30 days.
Effectively：Body weight loss >=3kg in 30 days.
It is invalid：Body weight does not decline in 30 days.
4. result
During experiment, there are the adverse reactions such as stomachache, diarrhea, flatulence in none patient in 6 embodiment groups；
In control group 1 (Western medicine), there are 21 patients abdominal discomfort, flatulence, diarrhea (steatorrhea or watery stool), tooth or tooth occur
There is headache, menstrual disorder in the adverse reactions such as tooth discomfort, 1 female patient；In control group 1 (Western medicine), there are 7 patients abdomen occur
Bitterly, the adverse reaction such as diarrhea, fash.By 30 days try out, the total effective rate of each embodiment group was above up to more than 94%
Control group 2 (Chinese medicine), it is suitable with the total effective rate of control group 1 (Western medicine), illustrate that product of the present invention has preferable antiobesity action, and
And safe without toxic side effect.It is shown in Table 5.
The curative effect comparative result of table 5
It is several typical examples below：
Exemplary 1
Huang, man, 42 years old, 1.78 meters of height, 128 kilograms of body weight, belong to severe simple obesity.The product of the embodiment of the present invention 3 is taken,
Body weight is 119 kilograms after 30, subtracts 9 kilograms.
Exemplary 2
Lee, female, 38 years old, 1.58 meters of height, 98 kilograms of body weight, belong to central obesity.With the product of the embodiment of the present invention 5,30
Body weight is 88 kilograms after it, subtracts 10 kilograms.
Exemplary 3
The Qin, female, 27 years old, 1.63 meters of height, 69 kilograms of body weight, belong to overweight.The product of the embodiment of the present invention 1 is taken,
Body weight is 63 kilograms after 30 months, subtracts 6 kilograms, is discontinued 3 months and has no bounce-back.
The specific implementation of the invention is not to be limited to these illustrations for above content, is led for technology belonging to the present invention
For the those of ordinary skill in domain, without departing from the inventive concept of the premise, some simple deduction or replace can also be made,
The scope of patent protection that the present invention is determined by the claims submitted should be all considered as belonging to.The present invention is considered as belonging to by institute
The scope of patent protection that claims of submission determine.
Claims (10)
1. a kind of Chinese medicine for losing weight composition, it is characterised in that include the raw material of following parts by weight：Gynostemma pentaphylla 5-25 parts, cassia seed
2-22 parts, radish seed (stir-fry) 3-10 parts, fructus cannabis 5-20 parts, citrus chachiensis hortorum 2-8 parts, Poria cocos 5-20 parts, lotus leaf 2-10 parts, Chinese Fevervine Herb
3-15 parts, green tea 1-6 parts.
2. Chinese medicine for losing weight composition according to claim 1, it is characterised in that including following raw material：Gynostemma pentaphylla
15 parts, 12 parts of cassia seed, 6 parts of radish seed (stir-fry), 12 parts of fructus cannabis, 5 parts of citrus chachiensis hortorum, 12 parts of Poria cocos, 7 parts of lotus leaf, Chinese Fevervine Herb 8
Part, 3 parts of green tea.
3. Chinese medicine for losing weight composition according to claim 1 or 2, it is characterised in that prepared by the Chinese medicine for losing weight composition
Into medicinal tea, capsule, pill, tablet, granule.
4. a kind of Chinese medicine for losing weight composition according to claim 3 is prepared into the preparation method of medicinal tea, it is characterised in that bag
Include following steps：
S1. gynostemma pentaphylla, cassia seed, radish seed (stir-fry), fructus cannabis, citrus chachiensis hortorum, Poria cocos, lotus leaf, Chinese Fevervine Herb, green tea are taken respectively, only
Choosing, clean, dry；
S2. weighed by following parts by weight：Gynostemma pentaphylla 5-25 parts, cassia seed 2-22 parts, radish seed (stir-fry) 3-10 parts, fructus cannabis 5-20
Part, citrus chachiensis hortorum 2-8 parts, Poria cocos 5-20 parts, lotus leaf 2-10 parts, Chinese Fevervine Herb 3-15 parts, green tea 1-6 parts；
S3. load weighted Chinese medicine is crushed, crosses 40-100 mesh sieves；
S4. mix, pack, seal, sterilizing, mechanical packaging, produce.
5. a kind of Chinese medicine for losing weight composition according to claim 3 is prepared into the preparation method of capsule, it is characterised in that
Comprise the following steps：
R1. gynostemma pentaphylla, cassia seed, radish seed (stir-fry), fructus cannabis, citrus chachiensis hortorum, Poria cocos, lotus leaf, Chinese Fevervine Herb, green tea are taken respectively, only
Choosing, clean, dry；
R2. weighed by following parts by weight：Gynostemma pentaphylla 5-25 parts, cassia seed 2-22 parts, radish seed (stir-fry) 3-10 parts, fructus cannabis 5-20
Part, citrus chachiensis hortorum 2-8 parts, Poria cocos 5-20 parts, lotus leaf 2-10 parts, Chinese Fevervine Herb 3-15 parts, green tea 1-6 parts；
R3. load weighted medicinal material is added water to cook, filters, obtain filtrate；
R4. thick paste is concentrated the filtrate to, dry, pulverize, is sieved, get dry extract fine powder；
R5. dry cream fine powder is taken, adds filler and lubricant, is mixed, loads capsule, produces.
6. Chinese medicine for losing weight composition according to claim 5 is prepared into the preparation method of capsule, it is characterised in that step
Decocted described in R3 to add water to cook 2 times, for the first time plus 2-3 hours are boiled in the 10-15 times of decocting measured, second plus the 5-10 times of water measured
Decoct 1-2 hours.
7. Chinese medicine for losing weight composition according to claim 5 is prepared into the preparation method of capsule, it is characterised in that step
The relative density of thick paste described in R4 is 1.03-1.05 at 70 DEG C.
8. Chinese medicine for losing weight composition according to claim 5 is prepared into the preparation method of capsule, it is characterised in that step
Drying temperature described in R4 is 60-70 DEG C, drying time 6-8h.
9. Chinese medicine for losing weight composition according to claim 5 is prepared into the preparation method of capsule, it is characterised in that step
Sieving was 100-120 mesh sieves described in R4.
10. Chinese medicine for losing weight composition according to claim 5 is prepared into the preparation method of capsule, it is characterised in that step
Filler described in rapid R5 is one or more kinds of combinations in starch, microcrystalline cellulose, lactose and dextrin, and the lubricant is
One or more kinds of combinations in magnesium stearate, talcum powder and silica.
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Cited By (3)
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| CN108432914A (en) * | 2018-03-13 | 2018-08-24 | 贵州健安德科技有限公司 | Formula of Chinese medicinal tea for losing weight and preparation method thereof |
| CN112022984A (en) * | 2020-09-15 | 2020-12-04 | 河南融易健康科技有限公司 | Preparation for removing food retention, preparation method and application thereof |
| CN114712466A (en) * | 2022-04-08 | 2022-07-08 | 贵州中医药大学 | Medicine with weight-losing and face-beautifying effects and preparation method thereof |
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| CN108432914A (en) * | 2018-03-13 | 2018-08-24 | 贵州健安德科技有限公司 | Formula of Chinese medicinal tea for losing weight and preparation method thereof |
| CN112022984A (en) * | 2020-09-15 | 2020-12-04 | 河南融易健康科技有限公司 | Preparation for removing food retention, preparation method and application thereof |
| CN114712466A (en) * | 2022-04-08 | 2022-07-08 | 贵州中医药大学 | Medicine with weight-losing and face-beautifying effects and preparation method thereof |
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Application publication date: 20180116 |