CN103156889A - Capsule for enhancing bone mineral density, and preparation method thereof - Google Patents
Capsule for enhancing bone mineral density, and preparation method thereof Download PDFInfo
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- CN103156889A CN103156889A CN2011104130871A CN201110413087A CN103156889A CN 103156889 A CN103156889 A CN 103156889A CN 2011104130871 A CN2011104130871 A CN 2011104130871A CN 201110413087 A CN201110413087 A CN 201110413087A CN 103156889 A CN103156889 A CN 103156889A
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Abstract
The invention discloses a capsule for enhancing bone mineral density, and a preparation method thereof. The capsule comprises the components of, by weight, 33.25 parts of glucosamine hydrochloride, 31.25 parts of calcium carbonate, 20.75 parts of rhzizoma drynariae, 12.5 parts of microcrystalline cellulose and 2.25 parts of silica powder. The capsule for enhancing the bone mineral density can reach an effect for enhancing the bone mineral density. The capsule is prepared by scientific and reasonable production process according to a health-care theory for increasing the bone mineral density, by using the glucosamine hydrochloride, the calcium carbonate and the rhzizoma drynariae are used as main raw materials. The product has a definite function and controllable quality and is safe for taking. The preparation method of the capsule for enhancing the bone mineral density is simple and can finish the preparation of the capsule by a common apparatus.
Description
Technical field
The invention belongs to the health care medicine technical field, relate to a kind of health product capsule, particularly a kind of enhancing bone density capsule and preparation method thereof.
Background technology
The expection of exploitation strength of calligraphic strokes source capsule product reaches the health care that increases bone density.This product according to increasing bone density health care theory, adopts scientific and reasonable production technology to process take glucosamine hydrochloride, calcium carbonate, Rhizoma Drynariae as primary raw material, and this product function is clear and definite, and is quality controllable, takes safety.Osteoporosis (Osteoporosis, OP) be a kind of general skeletal diseases that is caused by many reasons, it reduces with the bone amount, and bone density descends, the osseous tissue microstructure deteriorates to feature, causes bone fragility to increase and follows the increase at age and a kind of degenerative osteopathy of occuring.Osteoporosis is a kind of Senile disease, and the women falls ill higher than the male, is caused dysostosis and formed by many reasons.
Summary of the invention
Purpose of the present invention aims to provide a kind of enhancing bone density capsule and preparation method thereof, the existing calcium carbonate of this product is the basic comprising material of calcium as a supplement, there are again glucosamine hydrochloride and Rhizoma Drynariae extract to promote calcareously better to be absorbed, block calcareous loss by skeleton, increase the toughness of bone.Each composition synergism promotes calcareous absorption to increase the effect of bone density thereby reach.
Technical scheme of the present invention is: design a kind of enhancing bone density capsule, it is characterized in that composition and weight proportion thereof that it contains are: 33.25 parts of glucosamine hydrochloride, 31.25 parts of calcium carbonate, 20.75 parts of Rhizoma Drynariae, 12.5 parts of microcrystalline Cellulose, 2.25 parts of micropowder silica gels.
Described a kind of preparation method that strengthens the bone density capsule is characterized in that it comprises the following steps:
1) by following weight ratio weighting raw materials: 33.25 parts of glucosamine hydrochloride, 31.25 parts of calcium carbonate, 20.75 parts of Rhizoma Drynariae, 12.5 parts of microcrystalline Cellulose, micropowder silica gel .2.25 part;
2) accurately take above-mentioned supplementary material, cross 80 mesh sieves, batching;
The supplementary material that 3) will the take mix homogeneously in mixer of packing into, standby;
4) with said mixture (4), upper capsule filling machine carries out filling, gets final product;
5) inner packing;
6) outer package, product inspection, warehouse-in.
Glucosamine in the present invention is a kind of natural amino monosaccharide, is the base substance of synthesizing amino polysaccharide, is also the constituent of proteoglycan in articular cartilage: calcium carbonate is white powder, odorless, tasteless.Its calcium content is high, and bioavailability is good, has no side effect, and is a kind of important calcium-supplementing preparation, is widely used in the world; Rhizoma Drynariae bitter in the mouth warm in nature is returned liver, kidney channel.Has the continuous wound of invigorating blood circulation, the effect of the kidney invigorating bone strengthening.Be used for the treatment of deficiency of the liver and kindey, soreness of waist and knee joint, muscles and bones unable, have a dizzy spell.Each raw material all plays a role from different aspects to increasing bone density, and calcium carbonate plays the effect of the basic substance that increases bone density as the primary raw material that increases bone density; The glucosamine hydrochloride element can be regulated body to calcareous absorption, and bone propagation is played special regulating action; Rhizoma Drynariae extract significantly improves osteoblast activity by promoting osteoblastic propagation, obvious promoting bone growing, and enhancing bone reconstruction etc. reaches control and improves osteoporotic effect.This formula can be treated osteoporosis, replenishes the nutrition of articular cartilage, strengthens elasticity and the toughness in joint.
Advantage of the present invention is: strength of calligraphic strokes source capsule of the present invention is take glucosamine hydrochloride, calcium carbonate, Rhizoma Drynariae as primary raw material, for a health food of osteoporosis crowd exploitation.The existing calcium carbonate of this product is the basic comprising material of calcium as a supplement, has again glucosamine hydrochloride and Rhizoma Drynariae extract to promote calcareously better to be absorbed, block calcareous loss by skeleton, increases the toughness of bone.Each composition synergism, thus reach the effect that strengthens bone density.And do not contain hormones, anesthesia class, stimulate the class material, no dependence has no side effect to human body.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, but not as limitation of the present invention.The part that is not described in detail in the present embodiment is to adopt prior art, and industry standard or known approaches.
Embodiment
Enhancing bone density capsule that the described embodiment of the present invention provides and preparation method thereof adopts following steps to make:
1) take raw material by following weight ratio: 33.25 parts of glucosamine hydrochloride, 31.25 parts of calcium carbonate, 20.75 parts of Rhizoma Drynariae, 12.5 parts of microcrystalline Cellulose, micropowder silica gel .2.25 part;
2) accurately take above-mentioned supplementary material, cross 80 mesh sieves, batching;
The supplementary material that 3) will the take mix homogeneously in mixer of packing into, standby;
4) with said mixture (4), upper capsule filling machine carries out filling, gets final product;
5) inner packing;
6) outer package, product inspection, warehouse-in.
Strength of calligraphic strokes source capsule clinical testing data of the present invention
The inventor is according to the human feeding trial rules, 240 routine patients with osteoarthritis adopted the research method of multicenters, random, double blinding, is divided into test group, matched group, according to the contrast principle of 1:1, and every group of 120 examples.Test group is taken and is observed the enhancing bone density capsule that sample is made according to the embodiment of the present invention, matched group is taken placebo (outsourcing has the U.S. board soybean isoflavone of the angel capsule that strengthens bone substance density improving function), each 3, every day 3 times, took continuously 3 months, and followed up a case by regular visits to and observe its clinical efficacy and untoward reaction.Result shows that capsule group treatment osteoarthritis total effective rate is 92.5%, and quality of life of patients obviously improves.The placebo group effective percentage is 20.8%, and relatively there were significant differences (p＜0.05) with test group.Capsule group adverse reaction rate is respectively 0.8%.The prompting embodiment of the present invention strengthens bone density capsule for treating osteoarthritis good effect, and is safe.The no abnormality seens such as spirit, sleep, diet, defecation before and after the test group experiment.The duration of test normal diet does not change original dietary habit, illustrates that observed sample copy inventive embodiments strengthens the bone density capsule and belongs to health without impact.Cut out the embodiment of the present invention strengthen the bone density capsule after 5 days experimenter's indices all normal, illustrate that strength of calligraphic strokes source capsule does not have dependency.According to the criterion of " health food check and assessment technique standard ", think that the embodiment of the present invention strengthens the bone density capsule and has defecating feces excretion, and respond well.
Claims (2)
1. one kind strengthens the bone density capsule, it is characterized in that composition and weight proportion thereof that it contains are: 33.25 parts of glucosamine hydrochloride, 31.25 parts of calcium carbonate, 20.75 parts of Rhizoma Drynariae, microcrystalline Cellulose 12.5, micropowder silica gel .2.25 part.
2. the preparation method by above-mentioned enhancing bone density capsule is that it comprises the following steps:
1) take raw material by following weight ratio: 33.25 parts of glucosamine hydrochloride, 31.25 parts of calcium carbonate, 20.75 parts of Rhizoma Drynariae, microcrystalline Cellulose 12.5, micropowder silica gel .2.25 part;
2) accurately take above-mentioned supplementary material, cross 80 mesh sieves, batching;
The supplementary material that 3) will the take mix homogeneously in mixer of packing into, standby;
4) with said mixture (4), upper capsule filling machine carries out filling, gets final product;
5) inner packing;
6) outer package, product inspection, warehouse-in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104130871A CN103156889A (en) | 2011-12-10 | 2011-12-10 | Capsule for enhancing bone mineral density, and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104130871A CN103156889A (en) | 2011-12-10 | 2011-12-10 | Capsule for enhancing bone mineral density, and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103156889A true CN103156889A (en) | 2013-06-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011104130871A Pending CN103156889A (en) | 2011-12-10 | 2011-12-10 | Capsule for enhancing bone mineral density, and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362308A (en) * | 2015-12-07 | 2016-03-02 | 天津中新药业集团股份有限公司达仁堂制药厂 | Bone density increasing tablet and method for preparing same |
| CN105362307A (en) * | 2015-12-07 | 2016-03-02 | 天津中新药业集团股份有限公司达仁堂制药厂 | Traditional Chinese medicine composition capable of increasing bone mineral density and preparation method thereof |
| CN105410941A (en) * | 2015-12-08 | 2016-03-23 | 湖南洞庭水殖珍珠有限公司 | Serene Tablet health-care food capable of increasing bone density and strengthening immunity and preparation method thereof |
| CN107960663A (en) * | 2017-11-24 | 2018-04-27 | 南通励成生物工程有限公司 | Carbonic acid calcium-nutrition intensifying agent and preparation method |
-
2011
- 2011-12-10 CN CN2011104130871A patent/CN103156889A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362308A (en) * | 2015-12-07 | 2016-03-02 | 天津中新药业集团股份有限公司达仁堂制药厂 | Bone density increasing tablet and method for preparing same |
| CN105362307A (en) * | 2015-12-07 | 2016-03-02 | 天津中新药业集团股份有限公司达仁堂制药厂 | Traditional Chinese medicine composition capable of increasing bone mineral density and preparation method thereof |
| CN105410941A (en) * | 2015-12-08 | 2016-03-23 | 湖南洞庭水殖珍珠有限公司 | Serene Tablet health-care food capable of increasing bone density and strengthening immunity and preparation method thereof |
| CN107960663A (en) * | 2017-11-24 | 2018-04-27 | 南通励成生物工程有限公司 | Carbonic acid calcium-nutrition intensifying agent and preparation method |
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Application publication date: 20130619 |