CN1449746A - Soft capsule containing trace element - Google Patents
Soft capsule containing trace element Download PDFInfo
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- CN1449746A CN1449746A CN03116773A CN03116773A CN1449746A CN 1449746 A CN1449746 A CN 1449746A CN 03116773 A CN03116773 A CN 03116773A CN 03116773 A CN03116773 A CN 03116773A CN 1449746 A CN1449746 A CN 1449746A
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- trace element
- soft capsule
- vitamin
- milligrams
- grease
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Abstract
The present invention relates to a troce element softcapsule. The trace element in said capsule can be isolated from oil matter in the capsule, and it is characterized by that the oily matter is covered with gelatin containing trace element.
Description
The present invention relates to a kind of soft capsule that contains trace element in rubber, the trace element of indication is ferrum, zinc, germanium, copper, manganese, chromium, selenium, fluorine, iodine.
The people sick, old,, extremely all be in the same place with biomolecule (as protein, peptide, lipid, polysaccharide, hormone and vitamin) close ties, but the past does not obtain enough understanding to the relation of trace element and health.Progressively raising along with people's living standard, constantly advancing of the development of society, science and technology, life sciences more and more causes people's attention, studies show that in a large number, trace element and above-mentioned biomolecule have substantial connection, life process to the people plays regulating and controlling effect, and most results of study all show, trace element and people's health, disease, longevity, intelligence, beauty treatment etc. are relevant.Trace element and other are had a coordinative role on physiology active substance combination together; can play unthinkable effect; for example the selenic biological function of the non-oxidizability of vitamin E and trace element is closely related; the two is in different angles; play strong oxidation, protection biomembrane, delaying sanility process; for example selenium and beta-carotene all have the effect of cancer-resisting and angiocardiopathy preventing again, and these all are well-known.
Combine containing fat-soluble biological active substances and trace element, by traditional method is exactly that trace element is suspended in the grease of fat-soluble biological active substances, this method causes the muddiness, rotten of soft capsule content unavoidably, muddy not only lose attractive in appearance but also the drink person can think that the generation of sneaking into of foreign body probably avoids by mistake, worried taking, rotten meeting makes the decline of tiring.No. the 2298137th, British patent, particle diameter to the solids in the solution in the soft capsule has been done qualification, be in the capsule 's content solid contents less than 10%, then the solids particle diameter should be less than 5 microns, less than 1%, then can prevent the precipitation of solid material in the capsule like this, but the content in solids and the capsule is in contact with one another bring perishable and does not overcome yet in capsular muddiness and the capsule greater than 400 microns.
The objective of the invention is to, will in grease, sneak in the rubber shell of soft capsule by insoluble trace element, make with capsule in content isolate, cause the reduction of tiring of the muddy and preparation of capsule 's content to prevent trace element, and make simplified manufacturing process.
The present invention is achieved in that and will contains the grease of fat-soluble biological active substances, wraps up in the gelatin suitcase that contains non-fat-soluble trace element.
Trace element among the present invention refers to the thing that contains of ferrum, zinc, copper, manganese, chromium, germanium, selenium, fluorine, iodine, saidly contain the change that thing refers to trace element and contain thing such as sodium selenite, or its carrier contains thing as containing selenium yeast.
Trace element consists of 0.01～20% among the present invention in rubber, and its content is subjected to the quantity delivered of the every day of trace element, holds the quantitative limitation of trace element in the molecular weight of chemical compound or the carrier in the ratio of contained trace element and the rubber.Above-mentioned composition is in predetermined restricted.
Grease among the present invention is meant vegetable oil (as soybean oil, Oleum Arachidis hypogaeae semen, Radix Oenotherae erythrosepalae oil, oleum lini, safflower oil, Folium Perillae wet goods), aquatic animal oil (as fish oil, blubber oil, cod-liver oil etc.) and oily PEG400.
Biological active substances among the present invention is meant vitamin A, vitamin D, vitamin E, vitamin K, beta-carotene, lycopene, astaxanthin, phospholipid, propolis, bitter edible plant polyphenol, Squalene.
Trace element is sneaked into the method in the gelatin solution, water soluble trace elements is contained thing, can directly it be dissolved in the water of rubber shell prescription, water-insoluble trace element is contained thing, it can be dropped in the rubber shell prescription, by blender or mixing roll stirring or mixing, make its full and uniform dispersion in gelatin solution, make gelatin solution by well-established law again, mixing roll commonly used is a ball mill, mixing or stir in the bubble that produces can eliminate by the vacuum concentration deaeration.
Grease is wrapped up in the process that promptly prepares soft capsule with the gelatin suitcase and can be realized by following list of references: 1, drug application preparation technique version Beijing in 2000 Chinese Medicine science and technology publishing house, the 234th page; 2, pharmaceutical preparation engineering version in 2002, Chemical Industry Press, teaching material publishing centre, the 74th page 77 pages.
The present invention makes the work simplification of the soft capsule that contains trace element, grease content in trace element and the capsule is isolated, the reduction of tiring that prevents to interact and cause can also prevent to cause muddiness in the oily content owing to trace element is suspended in, and unlikelyly causes the drink person has no a sense of safety.
Example one:
(rubber shell component)
0.25 milligram of 0.11 milligram of ethyl hydroxybenzoate of sodium selenite
0.08 milligram of 75.1 milligrams of propylparaben of gelatin
22.5 milligrams of glycerol
(grease)
100 milligrams of vitamin Es are diluted to 250 milligrams with refined plant oil
With the rubber shell component and the grease of aforementioned proportion,, make special-shaped soft capsule by the die pressing of preceding note list of references.
Real row two:
(rubber shell component)
21 milligrams of 0.11 milligram of glycerol of sodium selenite
0.25 milligram of 7.5 milligrams of ethyl hydroxybenzoate of zinc oxide
0.08 milligram of 70 milligrams of propylparaben of gelatin
(grease)
116 milligrams of 100 milligrams of refined plant oil of vitamin E
34 milligrams of 30% oiliness beta-carotene
Rubber shell component and water are even through the ball mill ball milling, use the rubber shell component and the grease of aforementioned proportion then, by the die pressing of preceding note list of references, make special-shaped soft capsule.
Example three:
(rubber shell component)
0.25 milligram of sodium selenite 0.055 microgram ethyl hydroxybenzoate
0.08 milligram of 75.1 milligrams of propylparaben of gelatin
22.5 milligrams of glycerol
(grease)
25 milligrams of tea polyphenols
225 milligrams of PEG400s
With the rubber shell component and the grease of aforementioned proportion,, make special-shaped soft capsule by the die pressing of preceding note list of references.
Example four:
(rubber shell component)
43 milligrams of 0.11 milligram of glycerol of sodium selenite
0.5 milligram of 7.5 milligrams of ethyl hydroxybenzoate of zinc oxide
0.16 milligram of 143 milligrams of propylparaben of gelatin
(grease)
120 milligrams of 100 milligrams of propolis of vitamin E
246 milligrams of 34 milligrams of refined plant oil of 30% oiliness beta-carotene
Rubber shell component and water, even through the ball mill ball milling, use the rubber shell component and the grease of aforementioned proportion then, by the die pressing of preceding note list of references, make special-shaped capsule.
Example five:
(rubber shell component)
0.117 milligram of 5 milligrams of ethyl hydroxybenzoate of zinc oxide
0.039 milligram of 34.4 milligrams of propylparaben of gelatin
10.4 milligrams of glycerol
(grease)
Contain 3-Hydroxyretinol 000 Iu, the refined plant oil 120mg of D300 Iu, rubber shell component and water are even through the ball mill ball milling, use the rubber shell component and the grease of aforementioned proportion then, by the drop pill method of preceding note list of references, make the ball-type soft capsule.
Example six:
(rubber shell component)
19.8 milligrams of 13.6 milligrams of glycerol of ferrous sulfate
0.25 milligram of 57.7 milligrams of ethyl hydroxybenzoate of gelatin
0.08 milligram of 8.2 milligrams of propylparaben of sorbitol
(grease)
Contain 3-Hydroxyretinol 000 Iu, 250 milligrams of the refined plant oil of D300 Iu
With the rubber shell component and the grease of aforementioned proportion,, make special-shaped capsule by the compression moulding of preceding note list of references.
Claims (5)
1, a kind of soft capsule that contains trace element is characterized in that and will contain the grease of fat-soluble biological active substances, wraps up in containing the gelatin suitcase that non-fat-soluble trace element contains thing.
2,, it is characterized in that trace element contains thing and consist of 0.01～2% in the gelatin skin according to the described soft capsule of claim 1.
3, according to the described soft capsule of claim 1, what it is characterized in that trace element chosen from Fe, zinc, copper, manganese, chromium, germanium, selenium, fluorine, iodine contains thing, the said thing that contains, the carrier that refers to contain the chemical compound of trace element or contain trace element.
4,, it is characterized in that said grease is meant vegetable oil, aquatic animal oil, oily PEG400 according to the described soft capsule of claim 1.
5,, it is characterized in that said biological active substances is meant vitamin A, vitamin D, vitamin E, vitamin K, β-Hu square-bottomed bamboo basket Bu Su, lycopene, astaxanthin, phospholipid, propolis, bitter edible plant polyphenol, Squalene according to the described soft capsule of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN03116773XA CN1449746B (en) | 2003-05-07 | 2003-05-07 | Soft capsule containing trace element |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN03116773XA CN1449746B (en) | 2003-05-07 | 2003-05-07 | Soft capsule containing trace element |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1449746A true CN1449746A (en) | 2003-10-22 |
| CN1449746B CN1449746B (en) | 2012-01-04 |
Family
ID=28684263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN03116773XA Expired - Fee Related CN1449746B (en) | 2003-05-07 | 2003-05-07 | Soft capsule containing trace element |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1449746B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102511824A (en) * | 2011-12-20 | 2012-06-27 | 金利油脂（苏州）有限公司 | Antimutation and antitumor functional foodstuff |
| CN102894356A (en) * | 2012-08-15 | 2013-01-30 | 苏州谷力生物科技有限公司 | Anti-aging anti-oxidation composition |
| CN103719301A (en) * | 2013-12-24 | 2014-04-16 | 青岛银色世纪健康产业集团有限公司 | Healthy food taking astaxanthin oil as main material |
| CN103750562A (en) * | 2014-01-15 | 2014-04-30 | 中国烟草总公司广东省公司 | Squalene and beta-carotene composition polycystic lipidosome preparation method and application thereof for decreasing free radical and reducing harm |
| CN103767070A (en) * | 2014-01-15 | 2014-05-07 | 中国烟草总公司广东省公司 | Preparation method of squalene and astaxanthin composition liquid precursor lipidosome and radical reducing and harm reduction application of squalene and astaxanthin composition liquid precursor lipidosome |
| CN103859588A (en) * | 2014-03-20 | 2014-06-18 | 广西中烟工业有限责任公司 | Preparation method of squalene and astaxanthin composite multivesicular liposome and radical lowering and harm reducing method thereof |
| CN104886567A (en) * | 2015-05-13 | 2015-09-09 | 宁波北仑戌鸿农业科技有限公司 | Selenium containing health-care food |
| CN105077268A (en) * | 2015-07-10 | 2015-11-25 | 江苏艾兰得营养品有限公司 | Soft capsule preparation containing multivitamins, plant extracts and microelements and preparation method of soft capsule preparation |
| CN108065404A (en) * | 2017-12-12 | 2018-05-25 | 深圳市博奥生物科技有限公司 | Health products and its production method with replenishing vitamins AD effects |
-
2003
- 2003-05-07 CN CN03116773XA patent/CN1449746B/en not_active Expired - Fee Related
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102511824A (en) * | 2011-12-20 | 2012-06-27 | 金利油脂（苏州）有限公司 | Antimutation and antitumor functional foodstuff |
| CN102894356A (en) * | 2012-08-15 | 2013-01-30 | 苏州谷力生物科技有限公司 | Anti-aging anti-oxidation composition |
| CN103719301A (en) * | 2013-12-24 | 2014-04-16 | 青岛银色世纪健康产业集团有限公司 | Healthy food taking astaxanthin oil as main material |
| CN103750562B (en) * | 2014-01-15 | 2015-08-05 | 中国烟草总公司广东省公司 | The preparation method of squalene and beta carotene composition multivesicular liposome and fall base harm reduction and apply |
| CN103767070A (en) * | 2014-01-15 | 2014-05-07 | 中国烟草总公司广东省公司 | Preparation method of squalene and astaxanthin composition liquid precursor lipidosome and radical reducing and harm reduction application of squalene and astaxanthin composition liquid precursor lipidosome |
| CN103750562A (en) * | 2014-01-15 | 2014-04-30 | 中国烟草总公司广东省公司 | Squalene and beta-carotene composition polycystic lipidosome preparation method and application thereof for decreasing free radical and reducing harm |
| CN103767070B (en) * | 2014-01-15 | 2015-08-05 | 中国烟草总公司广东省公司 | The preparation method of squalene and astaxanthin composition liquid precursor liposome and fall base harm reduction and apply |
| CN103859588A (en) * | 2014-03-20 | 2014-06-18 | 广西中烟工业有限责任公司 | Preparation method of squalene and astaxanthin composite multivesicular liposome and radical lowering and harm reducing method thereof |
| CN103859588B (en) * | 2014-03-20 | 2016-04-13 | 广西中烟工业有限责任公司 | The preparation of squalene and astaxanthin composition multivesicular liposome and fall base harm reduction |
| CN104886567A (en) * | 2015-05-13 | 2015-09-09 | 宁波北仑戌鸿农业科技有限公司 | Selenium containing health-care food |
| CN105077268A (en) * | 2015-07-10 | 2015-11-25 | 江苏艾兰得营养品有限公司 | Soft capsule preparation containing multivitamins, plant extracts and microelements and preparation method of soft capsule preparation |
| CN105077268B (en) * | 2015-07-10 | 2017-11-28 | 江苏艾兰得营养品有限公司 | A kind of soft capsule preparation containing multivitamin and plant extracts and trace element and preparation method thereof |
| CN108065404A (en) * | 2017-12-12 | 2018-05-25 | 深圳市博奥生物科技有限公司 | Health products and its production method with replenishing vitamins AD effects |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1449746B (en) | 2012-01-04 |
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