CN106387352A - Microcapsule animal immunoenhancer containing tea polyphenol and preparation method of immunoenhancer - Google Patents
Microcapsule animal immunoenhancer containing tea polyphenol and preparation method of immunoenhancer Download PDFInfo
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- CN106387352A CN106387352A CN201611073211.3A CN201611073211A CN106387352A CN 106387352 A CN106387352 A CN 106387352A CN 201611073211 A CN201611073211 A CN 201611073211A CN 106387352 A CN106387352 A CN 106387352A
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- tea polyphenols
- microcapsule
- inner core
- animal
- animal immunity
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Abstract
The invention discloses a microcapsule animal immunoenhancer containing tea polyphenol and a preparation method of the immunoenhancer. The immunoenhancer comprises an inner core and a wall material, wherein the inner core is prepared from raw materials including tea polyphenol, milkvetch root powder, vitamin E, mannan oligosaccharides and organic selenium through even mixing; the wall material is prepared from magaldrate, ethyl cellulose, methyl cellulose and butylated hydroxyanisole through even mixing. The inner core is added to the wall material twice, the immunoenhancer is prepared after high-speed stirring, even distribution of effective ingredients is facilitated, and the immunoenhancer is simple to operate and easy to popularize, facilitates absorption by animals after being added to animal feed and has the characteristics of being low in dosage, good in immune effect and low in cost.
Description
Technical field
The present invention relates to immunostimulant preparing technical field is and in particular to a kind of microcapsule animal immune containing tea polyphenols
Reinforcing agent and preparation method thereof.
Background technology
Immunostimulant is by different modes, reaches a para-immunity medicine of enhancing human body immunity power.Clinically
It is usually used in treating the disease relevant with immunologic hypofunction and immunodeficiency.At present, in order to prevent, domesticated animal is sick,
Improve the resistances against diseases of animal, during raising, typically can add a certain proportion of antibiotic in feedstuff.But it is so long
The raising of time not only results in animal and develops immunity to drugs, and remain antibiotic in animal body pass through food chain directly or
Indirectly enter people's cognition and cause great hidden danger to healthy.Therefore people are highly desirable a kind of health of pure natural, no
The animal immunity potentiator of toxic and side effects, to improve the resistances against diseases of animal.
Although the research about animal immunity potentiator gradually increases at present, the immunostimulant generally existing of preparation is used
Amount is big, immune effect is general, and the shortcomings of put into big, partial immunity reinforcing agent even has reduction breeding performonce fo animals, causes
The toxic and side effects such as multiple diseases, easily remain, and easily pollute environment.
Content of the invention
For solve above-mentioned technical problem, the invention provides a kind of microcapsule animal immunity potentiator containing tea polyphenols and its
Preparation method.
The present invention is achieved by the following technical programs：
A kind of microcapsule animal immunity potentiator containing tea polyphenols, the animal immunity potentiator that this contains tea polyphenols includes inner core
And wall material, inner core is made up of following raw material：Tea polyphenols 50-60, astragalus membranaceus powder 10-20, Vitamin E 10-20, manna are few
Sugared 5-12, organic selenium 2-6, wall material is made up of following raw material：Magaldrate 3-8, ethyl cellulose 5-10, methyl are fine
The plain 2-3 of dimension, Butylated hydroxyanisole 2-6.
Tea polyphenols are the general names of Polyphenols of Tea, including flavanol compound, anthocyanin class, flavonoid, flavonols
With phenolic acids etc..Research shows, tea polyphenols isoreactivity material tool detoxifies and radiation resistance, can effectively stop radioactive substance
Invade bone marrow, and strontium 90 and Co 60 can be made to excrete rapidly, " radiation jinx " is described as by health and medical circle.
The Radix Astragali has enhancing human body immunity function, liver protection, diuresis, defying age, anti-stress, blood pressure lowering and wide antibacterial to make
With.Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, adjust blood sugar content.The Radix Astragali can not only coronary artery dilator,
Improve blood supply of cardiac muscle, improve immunologic function, and be capable of the process of delaying cell aging.
Vitamin E has different physiological roles, as natural fat-soluble chain breaking antioxidants, can stop intracellular insatiable hunger
And lipid oxidation, protect cell membrane from oxidative damage, maintain cell integrity.
Mannooligo saccharide is also called manna oligosaccharide, is the class novel antigens active matter extracting from Yeast Cultivation cell wall
Matter, is widely present in Rhizoma amorphophalli powder, guar gum, sesbania gum and multiple-microorganism cell wall.Because it not only has low grade fever, steady
The good physicochemical properties such as fixed, safety non-toxic, also have the protection effect such as intestinal and enhance immunity.
Organic selenium is to be combined into aminoacid through bioconversion, typically presented in Selenomethionine, with Vitamin E
There is synergism, strengthen product non-oxidizability.
The weight of described inner core and wall material is than for 1：2-5.
As additive, consumption in feedstuff is 100-400mg/ to the described microcapsule animal immunity potentiator containing tea polyphenols
kg.
A kind of microcapsule animal immunity potentiator preparation method containing tea polyphenols, this contains the microcapsule animal immune of tea polyphenols
Reinforcing agent preparation method is：
1) tea polyphenols, astragalus membranaceus powder, Vitamin E, mannooligo saccharide, organic selenium mix to obtain inner core；
2) magaldrate, ethyl cellulose, methylcellulose, Butylated hydroxyanisole mix and stir and to obtain wall material, so
Make after adding inner core high-speed stirred drying afterwards.
In described 1), inner core is divided into two parts of size, and both part by weight are 1：0.3-0.8, first by the one large addition in inner core
Stir in wall material, then add the aliquot of inner core.
Described high-speed stirred speed is 200-800r/min, and mixing time is 10-35min.
Described drying is process 15-35min at 28-45 DEG C.
As additive, consumption in feedstuff is 100-400mg/ to the described microcapsule animal immunity potentiator containing tea polyphenols
kg.
The beneficial effects of the present invention is：In the animal immunity potentiator of present invention preparation, core raw material is by tea polyphenols, the Radix Astragali
Powder, Vitamin E, mannooligo saccharide, organic selenium mix and make, and by certain proportioning, the characteristic being sufficiently used each raw material makes
Product has antiinflammatory, antiviral, anti-stress, the function of enhancing human body immunity, it is to avoid cell membrane suffers from oxidative damage, reaches wide spectrum
Antibacterial and environmental protection.And wall material is then mixed by magaldrate, ethyl cellulose, methylcellulose, Butylated hydroxyanisole
Make, this animal immunity potentiator is the form of microcapsule, made by stirring cold drying, be so conducive to keeping in raw material
Beneficial, inner core adds at twice in wall material and is conducive to being uniformly distributed of beneficial, and simple to operate easy to spread,
Make an addition to the absorption not only contributing to animal in animal feed, also have that consumption is few, immune effect substantially, the feature of low cost.
Specific embodiment
With reference to embodiments technical scheme is further described, but claimed scope is not limited to
In described.
Embodiment one
A kind of microcapsule animal immunity potentiator containing tea polyphenols, the animal immunity potentiator that this contains tea polyphenols includes inner core
And wall material, inner core is made up of following raw material：Tea polyphenols 50, astragalus membranaceus powder 10, Vitamin E 10, mannooligo saccharide 5, organic selenium
2, wall material is made up of following raw material：Magaldrate 3, ethyl cellulose 5, methylcellulose 2, Butylated hydroxyanisole
2.
The weight of inner core and wall material is than for 1：2.
As additive, consumption in feedstuff is 100mg/kg to microcapsule animal immunity potentiator containing tea polyphenols.
A kind of microcapsule animal immunity potentiator preparation method containing tea polyphenols, this contains the microcapsule animal immune of tea polyphenols
Reinforcing agent preparation method is：
1) tea polyphenols, astragalus membranaceus powder, Vitamin E, mannooligo saccharide, organic selenium mix to obtain inner core；
2) magaldrate, ethyl cellulose, methylcellulose, Butylated hydroxyanisole mix and stir and to obtain wall material, so
Make after adding inner core high-speed stirred drying afterwards.
By 1) in inner core be divided into two parts of size, both part by weight be 1：0.3, first by the one large addition wall material in inner core
Stirring, then adds the aliquot of inner core.
High-speed stirred speed is 200r/min, and mixing time is 35min.
Drying is process 15min at 28 DEG C.
As additive, consumption in feedstuff is 100mg/kg to microcapsule animal immunity potentiator containing tea polyphenols.
Embodiment two
A kind of microcapsule animal immunity potentiator containing tea polyphenols, the animal immunity potentiator that this contains tea polyphenols includes inner core
And wall material, inner core is made up of following raw material：Tea polyphenols 53, astragalus membranaceus powder 13, Vitamin E 15, mannooligo saccharide 7, organic selenium
3, wall material is made up of following raw material：Magaldrate 4, ethyl cellulose 7, methylcellulose 3, Butylated hydroxyanisole
3.
The weight of inner core and wall material is than for 1：3.
As additive, consumption in feedstuff is 200mg/kg to microcapsule animal immunity potentiator containing tea polyphenols.
A kind of microcapsule animal immunity potentiator preparation method containing tea polyphenols, this contains the microcapsule animal immune of tea polyphenols
Reinforcing agent preparation method is：
1) tea polyphenols, astragalus membranaceus powder, Vitamin E, mannooligo saccharide, organic selenium mix to obtain inner core；
2) magaldrate, ethyl cellulose, methylcellulose, Butylated hydroxyanisole mix and stir and to obtain wall material, so
Make after adding inner core high-speed stirred drying afterwards.
By 1) in inner core be divided into two parts of size, both part by weight be 1：0.5, first by the one large addition wall material in inner core
Stirring, then adds the aliquot of inner core.
High-speed stirred speed is 400r/min, and mixing time is 18min.
Drying is process 35min at 33 DEG C.
As additive, consumption in feedstuff is 100mg/kg to microcapsule animal immunity potentiator containing tea polyphenols.
Embodiment three
A kind of microcapsule animal immunity potentiator containing tea polyphenols, the animal immunity potentiator that this contains tea polyphenols includes inner core
And wall material, inner core is made up of following raw material：Tea polyphenols 56, astragalus membranaceus powder 17, vitamin e1 6, mannooligo saccharide 9, organic selenium
4, wall material is made up of following raw material：Magaldrate 6, ethyl cellulose 8, methylcellulose 3, Butylated hydroxyanisole
4.
The weight of inner core and wall material is than for 1：4.
As additive, consumption in feedstuff is 300mg/kg to microcapsule animal immunity potentiator containing tea polyphenols.
A kind of microcapsule animal immunity potentiator preparation method containing tea polyphenols, this contains the microcapsule animal immune of tea polyphenols
Reinforcing agent preparation method is：
1) tea polyphenols, astragalus membranaceus powder, Vitamin E, mannooligo saccharide, organic selenium mix to obtain inner core；
2) magaldrate, ethyl cellulose, methylcellulose, Butylated hydroxyanisole mix and stir, and are subsequently adding
Make after inner core high-speed stirred drying.
By 1) in inner core be divided into two parts of size, both part by weight be 1：0.7, first by the one large addition wall material in inner core
Stirring, then adds the aliquot of inner core.
Mixing speed is 330r/min, and mixing time is 25min.
Drying is process 22min at 37 DEG C.
As additive, consumption in feedstuff is 300mg/kg to microcapsule animal immunity potentiator containing tea polyphenols.
Example IV
A kind of microcapsule animal immunity potentiator containing tea polyphenols, the animal immunity potentiator that this contains tea polyphenols includes inner core
And wall material, inner core is made up of following raw material：Tea polyphenols 50-60, astragalus membranaceus powder 18, Vitamin E 19, mannooligo saccharide 10, have
Machine selenium 5, wall material is made up of following raw material：Magaldrate 7, ethyl cellulose 9, methylcellulose 2, butylhydroxy fennel
Fragrant ether 5.
The weight of inner core and wall material is than for 1：4.
As additive, consumption in feedstuff is 360mg/kg to microcapsule animal immunity potentiator containing tea polyphenols.
A kind of microcapsule animal immunity potentiator preparation method containing tea polyphenols, this contains the microcapsule animal immune of tea polyphenols
Reinforcing agent preparation method is：
1) tea polyphenols, astragalus membranaceus powder, Vitamin E, mannooligo saccharide, organic selenium mix to obtain inner core；
2) magaldrate, ethyl cellulose, methylcellulose, Butylated hydroxyanisole mix and stir, and are subsequently adding
Make after inner core high-speed stirred drying.
Mixing speed is 370r/min, and mixing time is 18min.
Drying is process 28min at 40 DEG C.
As additive, consumption in feedstuff is 360mg/kg to microcapsule animal immunity potentiator containing tea polyphenols.
Embodiment five
A kind of microcapsule animal immunity potentiator containing tea polyphenols, the animal immunity potentiator that this contains tea polyphenols includes inner core
And wall material, inner core is made up of following raw material：Tea polyphenols 50-60, astragalus membranaceus powder 20, Vitamin E 20, mannooligo saccharide 12, have
Machine selenium 6, wall material is made up of following raw material：Magaldrate 8, ethyl cellulose 10, methylcellulose 3, butylhydroxy
Methoxybenzene 6.
The weight of inner core and wall material is than for 1：5.
As additive, consumption in feedstuff is 400mg/kg to microcapsule animal immunity potentiator containing tea polyphenols.
A kind of microcapsule animal immunity potentiator preparation method containing tea polyphenols, this contains the microcapsule animal immune of tea polyphenols
Reinforcing agent preparation method is：
1) tea polyphenols, astragalus membranaceus powder, Vitamin E, mannooligo saccharide, organic selenium mix to obtain inner core；
2) magaldrate, ethyl cellulose, methylcellulose, Butylated hydroxyanisole mix and stir, and are subsequently adding
Make after inner core high-speed stirred drying.
By 1) in inner core be divided into two parts of size, both part by weight be 1：0.8, first by the one large addition wall material in inner core
Stirring, then adds the aliquot of inner core.
Mixing speed is 500r/min, and mixing time is 35min.
Drying is process 15min at 45 DEG C.
As additive, consumption in feedstuff is 400mg/kg to microcapsule animal immunity potentiator containing tea polyphenols.
Claims (8)
1. a kind of microcapsule animal immunity potentiator containing tea polyphenols it is characterised in that：The animal immune that this contains tea polyphenols strengthens
Agent includes inner core and wall material, and inner core is made up of following raw material：Tea polyphenols 50-60, astragalus membranaceus powder 10-20, Vitamin E 10-
20th, mannooligo saccharide 5-12, organic selenium 2-6, wall material is made up of following raw material：Magaldrate 3-8, ethyl cellulose 5-
10th, methylcellulose 2-3, Butylated hydroxyanisole 2-6.
2. a kind of microcapsule animal immunity potentiator containing tea polyphenols according to claim 1 it is characterised in that：Described interior
The weight of core and wall material is than for 1：2-5.
3. a kind of microcapsule animal immunity potentiator containing tea polyphenols according to claim 1 it is characterised in that：Described contain
As additive, consumption in feedstuff is 100-400mg/kg to the microcapsule animal immunity potentiator of tea polyphenols.
4. a kind of microcapsule animal immunity potentiator preparation method containing tea polyphenols it is characterised in that：This contains micro- glue of tea polyphenols
Capsule animal immunity potentiator preparation method is：
1) tea polyphenols, astragalus membranaceus powder, Vitamin E, mannooligo saccharide, organic selenium mix to obtain inner core；
2) magaldrate, ethyl cellulose, methylcellulose, Butylated hydroxyanisole mix and stir and to obtain wall material, Ran Houjia
Make after entering inner core high-speed stirred drying.
5. a kind of microcapsule animal immunity potentiator preparation method containing tea polyphenols according to claim 4, its feature exists
In：1) in, inner core is divided into two parts of size, and both part by weight are 1：0.3-0.8, first will stir in the one large addition wall material in inner core
Mix, then add the aliquot of inner core.
6. a kind of microcapsule animal immunity potentiator preparation method containing tea polyphenols according to claim 4, its feature exists
In：Institute's high-speed stirred speed is 200-800r/min, and mixing time is 10-35min.
7. a kind of microcapsule animal immunity potentiator preparation method containing tea polyphenols according to claim 4, its feature exists
In：Described drying is process 15-35min at 28-45 DEG C.
8. a kind of microcapsule animal immunity potentiator preparation method containing tea polyphenols according to claim 4, its feature exists
In：As additive, consumption in feedstuff is 100-400mg/kg to the described microcapsule animal immunity potentiator containing tea polyphenols.
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| CN201611073211.3A CN106387352A (en) | 2016-11-29 | 2016-11-29 | Microcapsule animal immunoenhancer containing tea polyphenol and preparation method of immunoenhancer |
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Cited By (2)
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| CN109279632A (en) * | 2018-10-30 | 2019-01-29 | 长沙兴嘉生物工程股份有限公司 | A kind of preparation method and applications of hydroxy chloride magnesium |
| CN109619315A (en) * | 2018-12-04 | 2019-04-16 | 安徽农业大学 | A kind of feed addictive and its preparation method and application improving birds, beasts and eggs polyphenol content |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109279632A (en) * | 2018-10-30 | 2019-01-29 | 长沙兴嘉生物工程股份有限公司 | A kind of preparation method and applications of hydroxy chloride magnesium |
| CN109279632B (en) * | 2018-10-30 | 2021-07-06 | 长沙兴嘉生物工程股份有限公司 | Preparation method and application of hydroxyl magnesium chloride |
| CN109619315A (en) * | 2018-12-04 | 2019-04-16 | 安徽农业大学 | A kind of feed addictive and its preparation method and application improving birds, beasts and eggs polyphenol content |
| CN109619315B (en) * | 2018-12-04 | 2022-11-18 | 安徽农业大学 | Feed additive for increasing polyphenol content of poultry eggs and preparation method and application thereof |
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Application publication date: 20170215 |