CN103536574A - Coenzyme Q10 soft capsule and preparation method thereof - Google Patents
Coenzyme Q10 soft capsule and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a coenzyme Q10 soft capsule and a preparation method thereof. The coenzyme Q10 soft capsule comprises the following components by mass percentage: 1-20 parts of coenzyme Q10, 30-95 parts of diluent, 1-50 parts of emulsifying agent and 1-30 parts of cosolvent. The invention also provides a preparation method of the coenzyme Q10 soft capsule. The coenzyme Q10 soft capsule not only has high stability but also achieves excellent effects in product dissolvability and content uniformity; as phosphatide is used as an emulsifying agent, the emulsified coenzyme Q10 soft capsule has higher stability and water in vivo and lipid substances can be fully mixed so as to improve the bioavailability of a medicament.
Description
Technical field
The present invention relates to a kind of coenzyme Q 10 soft capsule and preparation method thereof, belong to the technical field of pharmaceutical preparation.
Background technology
Coenzyme Q10 (coenzyme Q, ubiquinone) claim again coenzyme, ubiquinone and Q10, and chemistry CoQ10 by name, is fatsoluble vitamin analog.Nineteen fifty-seven, a gram Lay Enbrel scholar for the U.S. isolates coenzyme Q10 from the cardiac muscle of cattle, and the same year, the Morton professor of Britain also obtained this compound from the mouse liver of vitamin A defect, and by its name.Karl professor Folkers of 1958 Nian， Texas, USA universities has assert its chemical structural formula, and from then on the scholar of countries in the world has added in the research of coenzyme Q10.1972, gondola professor Littarru proved that lacking coenzyme Q10 is one of reason of the diseases such as cardiac trigger disease.1977, Japan realized microbiological industryization and has produced coenzyme Q10.1978, professor Mitchell explained that with chemiosmotic theory coenzyme Q10 plays important proton translocation effect in bio-energy transfer is included in energy conversion system, and has obtained Nobel chemistry Prize.Nineteen ninety, Karl Folkers professor's research shows that coenzyme Q10 has biostearin character.In Japan and European countries, about basic research and the clinical research of coenzyme Q10, launch extensively and profoundly, relate at present the independent element of coenzyme Q10 or the medicine of composite parts and surpass 100, the annual sales amount of the 2002 Nian U.S. surpasses 200,000,000.Coenzyme Q10 is the essential composition of the active tissue of energy metabolism, it concentrates on the mitochondrion in histiocyte, between complex I and Complex II, Main Function is metastatic electron between redox materials in electron transport chain, with this, produces through biomembranous electronic gradient.Coenzyme Q10 is accepted hydrogen from complex I and Complex II, by proton release to mitochondrial matrix, electronics passes to cytochrome, active by this process accelerating oxidation phosphorylation and electronics is shifted, form thus the main matter ATP that human body energy is stored, and improve ATP level by reducing myocardium AMP loss, reduce calcium ion and run off, stabilizing cell membrane and to maintain calcium channel complete.In addition, coenzyme Q10 has strong effect of scavenging radical, its mechanism of action be by transmit hydrogen to free radical after, under the effect of antioxidase, react, suppress the biomembranous damage of radical pair, be therefore used as natural antioxidant and free radical scavenger.
Along with the mechanism of action of coenzyme Q10 is revealed, it is widely used clinically, mainly contain the following aspects: (1) congestive heart failure, blood measuring by clinical heart disease patient is studied, find that patients with congestive heart failure cardiac muscle coenzyme Q10 content calibration ordinary person is low, confirmed that patients with congestive heart failure cardiac muscle endogenous coenzyme Q10 content is lower than normal level; And by cardiac muscle biopsy is shown, the patient that degree of heart failure is more serious, its myocardium coenzyme Q10 content is lower.By to finding after oral coenzyme Q10 treatment patients with congestive heart failure every day, patient respiration difficulty more than half and the clinical symptoms such as tired are significantly improved, and often fight capacity and Left Ventricular Ejection Fraction of oral coenzyme Q10 group patient obviously increases.(2) hypertension, coenzyme Q10 all has hypotensive effect to a certain degree to human body and animal.Because supplemented with exogenous coenzyme Q10 can increase the synthetic of ATP; can be used as the superoxidant state that free radical scavenger reduces blood vessel; reduce the superoxides of endotheliocyte and vascular smooth muscle cell; protect and alleviate the damage of vascular endothelial cell; reduce the level of endochylema NADH; promote vascular endothelial cell to discharge active substance NO, the PGI2 that can keep antiotasis, diastole peripheral blood vessel also reduces Peripheral resistance, plays the effect reducing blood pressure.(3) nervous system disease; exogenous coenzyme Q10 can improve the coenzyme Q10 deficiency state of pathological tissues; can pass through blood brain barrier; the apoptosis that minimizing causes due to cytolipin peroxide injury; or by stabilized cell membrane structure; maintain the integrity of calcium channel to reduce cell injury, slow down dopamine to mitochondrial damage, thereby play the effect of neuroprotective.(4) skin diseases, the photic damage such as skin photosensitivity reaction, photoaging and skin carcinoma that continuous light causes, be to produce a large amount of reactive oxygen specieses due to illumination, skin silicosis oxidant and anti-oxidant system is unbalance to be caused.By research, find, the generation of photoaging reduces relevant with the content of endogenous antioxidant coenzyme Q10, coenzyme Q10 can significantly suppress the expression of fell fibroblast hose lining Clotogen, thereby reduces the degraded of collagen in skin, many-sided damage that photoaging capable of blocking causes.(5) cancer, certain cancers patient blood ubiquinone l0 phenomenon on the low side has caused scientific research personnel's attention, the morbidity that a large number of experiments show that cancer is relevant with oxygen-derived free radicals, oxygen-derived free radicals cell membrane, mitochondrion, protein, lipid, DNA have destruction, supplement ubiquinone l0 and can consume a large amount of oxygen-derived free radicals, so coenzyme Q10 has certain treatment and preventive effect to cancerous protuberance.(6) antioxidation, resisting fatigue in sports medical science, ubiquinone l0 is the activator of cellular metabolism and Cellular respiration, is again natural antioxidant and free radical scavenger, has the important function of protection and recovery biofilm structure integrity.Take ubiquinone l0 and can reduce the rear serum CK level of motion, promote middle-distance runner's aerobic capacity to improve, effectively remove the free radical producing in motion, there is certain antifatigue effect, can improve muscle nutrition imbalance, improve the symptoms such as exercise tolerance, skelalgia, fatigue, can improve people's energy and mental.
【1-2】
Soft capsule is a kind of novel form growing up after sheet, injection, can be by oily medicine, drug solution or drug suspension, the pastel quantitative pressure injection of drug powder being encapsulated in glued membrane even, form size, different seal capsule.Compare with other dosage forms, possess the features such as bioavailability is high, content accurate, good uniformity, good looking appearance; If oily medicine, the technical finesse such as also can save absorption, solidify, can effectively avoid oily medicine to ooze out from absorb adjuvant, therefore the soft capsule optimum dosage form that is fat-soluble medicine.
Chinese patent literature CN101658510(application number: 200810012923.3) disclose a kind of ubiquinone
10self-emulsifying microcapsules and preparation method, be characterized in being comprised of by weight following raw material: ubiquinone
10: lipid: surfactant: wall material=1～20: 5～30: 5～30: 30～90; Its preparation method is to get respectively ubiquinone
10, lipid, surfactant, put into the material-compound tank with agitating device, be uniformly mixed, add 5-20 times of water, stir, form uniform solution, add wall material, be stirred to dissolve, spraying is dry, obtains ubiquinone
10self-emulsifying microcapsules.The present invention is a kind of self-emulsification solid preparation, by ubiquinone
10self-emulsifying composition is wrapped in microcapsule, improves ubiquinone
10self-emulsifiable preparation stability, can be in gastric juice automatic emulsified one-tenth microemulsion, increase ubiquinone
10absorption, improved drug effect, the diseases such as cardiovascular disease, hepatitis, hypoimmunity are had to better therapeutical effect.
Chinese patent literature CN103156193A(application number: 201310116545.4) disclose and a kind of coenzyme Q 10 soft capsule and preparation method thereof, content is comprised of the raw material of following component and percentage by weight: coenzyme Q10 1～20, vitamin E 0.1～10, Semen Maydis oil 70～95, Cera Flava 1～20, and by making utricule, prepare content, prepare the steps such as capsule and obtain coenzyme Q 10 soft capsule.Compared with prior art, the present invention be take coenzyme Q10 as main effect composition, be aided with natural Vitamin E, Semen Maydis oil and Cera Flava and make soft capsule preparation, the health care with enhancing immunity, constant product quality, taking convenience, meet the requirement of State Food and Drug Administration to health food, safe and effective, can long-term taking, be the health food that hypoimmunity crowd is desirable.
Chinese patent literature CN101897440A(application number: 200910238024.X) disclose a kind of coenzyme Q10 composite soft capsule and preparation method thereof, formed by softgel shell and capsule content; Capsule content consists of by weight following raw material: coenzyme Q10: zinc lactate: sodium selenite: vitamin E: Semen Maydis oil=1: (0.8-1.6): (0.001-0.005): (1.5-3.5): (15-25); The composition of soft capsule shell is gelatin, glycerol and pure water.Technique is: capsule material preparation: in gelatin, glycerol, water (0.5-2): (0.2-0.8): ratio (0.5-1.5), heating in water bath 50-95 ℃ dissolving, 45-80 ℃ of insulation.By formula ratio extracting lactic acid zinc and sodium selenite equivalent, increase progressively and mix, then mix homogeneously with coenzyme Q10, micronizing; Natural Vitamin E and Semen Maydis oil are put into 500-2000rpm and are stirred, and add mixing fine powders after must mixing oil plant, stir; Use automatic rotation rolling capsule machine to make coenzyme Q10 composite soft capsule.Advantage is: the stability that has greatly increased coenzyme Q10.
But the disclosed coenzyme Q10 capsule of above-mentioned patent documentation is mostly the stability of single pursuit medicine, and has ignored the effect of effective ingredient coenzyme Q10 medicine at aspects such as dissolution, uniformities.
Summary of the invention
For the deficiencies in the prior art, the invention provides a kind of coenzyme Q 10 soft capsule and preparation method thereof; Especially provide a kind of stability high, well behaved coenzyme Q 10 soft capsules in aspect such as dissolution and uniformity and preparation method thereof.
Technical scheme of the present invention is as follows:
, in capsule, the component of content and mass percent thereof are composed as follows:
Each component dosage sum is 100%; Described diluent is selected from one or more in soybean oil, Oleum Brassicae campestris, Oleum Ricini, almond oil, Semen Maydis oil, Oleum Gossypii semen, olive oil, Oleum Arachidis hypogaeae semen, Oleum Helianthi, Oleum sesami;
Described emulsifying agent is selected from one or more the mixing in phospholipid or phospholipid and following material:
Cera Flava, glyceryl monostearate, Brazil wax, polyglycol ether, arabic gum, albumin;
Described cosolvent is selected from one or more in glycerol triacetate, sodium lauryl sulphate, polysorbate 20, polysorbate 40, polysorbate 60, polyoxyethylene sorbitan monoleate, Macrogol 200, Liquid Macrogol, PEG400, Macrogol 600, Polyethylene Glycol 800, cetomacrogol 1000, polyethylene glycol 1500, Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, ethanol, isosorbide dimethyl ether, glycerol and propylene glycol.
According to the present invention, preferred, in described capsule, the component of content and mass percent thereof are composed as follows:
Each component dosage sum is 100%.
According to the present invention, preferred, in every coenzyme Q 10 soft capsule, the component of content and mass content thereof are as follows:
According to the present invention, preferred, in every coenzyme Q 10 soft capsule, the component of content and mass content thereof are as follows:
According to the present invention, preferred, in every coenzyme Q 10 soft capsule, the component of content and mass content thereof are as follows:
According to the present invention, preferred, in every coenzyme Q 10 soft capsule, the component of content and mass content thereof are as follows:
Coenzyme Q 10 soft capsule of the present invention main auxiliary material used all can be buied in market.
According to the present invention, the preparation method of described coenzyme Q 10 soft capsule, comprises the following steps:
(1) diluent of formula ratio is placed in to material-compound tank, adds emulsifying agent, heating makes emulsifiers dissolve and stirs;
(2) under step (1) solution temperature, add again the cosolvent of formula ratio, after stirring, be cooled to room temperature, obtain emulsion;
(3) coenzyme Q10 of getting formula ratio joins in the emulsion that step (2) makes, and stirs, and obtains the content medicinal liquid in capsule;
(4) gained content medicinal liquid in step (3) and softgel shell rubber are pressed into ball through encapsulating machine, dry, obtain.
According to the present invention, preferred, in step (1), heating for dissolving temperature is 60-90 ℃.
According to the present invention, preferred, the softgel shell rubber described in step (4) is to be made and make according to prior art by gelatin, glycerol, opacifier, antiseptic, pigment and water; Opacifier, antiseptic, pigment are selected from the conventional reagent in capsule shells preparation field.
Beneficial effect of the present invention:
1, not only stability is high for coenzyme Q 10 soft capsule of the present invention, and is all reaching good effect aspect product dissolution, content uniformity.
2, all kinds of vegetable oil are indispensable flavoring agent in people's life; it for soft capsule, is also good diluent; wherein contain multiple unsaturated fatty acid, there is the symptoms such as the blood fat of adjusting, cleaning thrombosis, enhancing immunity, protection retina, supplementing the brain brain-strengthening, ameliorate osteoarthritis.The present invention selects each vegetable oil as diluent, can promote the absorption of coenzyme Q10 and fat-soluble raw material, and produces better therapeutic effect with coenzyme Q10 generation synergism.
3, phospholipid is the biological active substances that forms one of biological cell membrane main component, it has regulating and controlling effect to physical function, can promote human body metabolism, enhancing immunity, strengthen the resistance of human body, clinically for preventing and treating the diseases such as cardiovascular and cerebrovascular vessel and liver, tumor.The fusing point of phospholipid is low, and after heating, dissolve complete is scattered in vegetable oil, can improve the uniformity of coenzyme Q10.The amphipathic property feature of phospholipid makes its advantage as emulsifying agent outstanding, and than the emulsify well of other emulsifying agents, the stability after emulsifying is higher; Phospholipid can make moisture and the lipid material in body fully mix, to improve the bioavailability of medicine.
4, in soft capsule, selectively use Cera Flava as emulsifying agent, can be good at improving the stability of emulsifying agent.The present invention is on the basis of using phospholipid as emulsifying agent, selectively Cera Flava, glyceryl monostearate, Brazil wax, polyglycol ether, arabic gum and albumin and phospholipid are used in conjunction with, not only can reach good emulsifying effectiveness, and avoid occurring the phenomenons such as layering that single emulsifier causes, flocculation.
The specific embodiment
Below by specific embodiment, the present invention will be further described, but be not limited to this.
In embodiment, supplementary material used is market and buys.
It is example that amounts of components in embodiment and comparative example all be take 1000 soft capsules.
Embodiment 1
Formula forms:
Preparation method:
The Oleum Helianthi of formula ratio is placed in to material-compound tank, add glyceryl monostearate, the heating that heats up is opened and is stirred simultaneously, makes to dissolve, in 60 ℃～90 ℃ left and right after glyceryl monostearate dissolves completely, the phospholipid, the glycerol that add successively formula ratio, stir, be cooled to room temperature and obtain emulsion, get the coenzyme Q10 of formula ratio, join in above-mentioned emulsion, stirring, it is standby to obtain medicinal liquid.By the above-mentioned medicinal liquid access softgel shell rubber configuring, through encapsulating machine, be pressed into ball, dry, obtain.
Embodiment 2
Formula forms:
Preparation method:
The Semen Maydis oil of formula ratio, soybean oil are placed in to material-compound tank, add Brazil wax, the heating that heats up is opened and is stirred simultaneously, makes to dissolve, in 60 ℃～90 ℃ left and right after Brazil wax dissolves completely, the phospholipid, the Polysorbate that add successively formula ratio, stir, be cooled to room temperature and obtain emulsion, get the coenzyme Q10 of formula ratio, join in above-mentioned emulsion, stirring, it is standby to obtain medicinal liquid.By the above-mentioned medicinal liquid access softgel shell rubber configuring, through encapsulating machine, be pressed into ball, dry, obtain.
Embodiment 3
Formula forms:
Preparation method:
The Oleum sesami of formula ratio is placed in to material-compound tank, add Cera Flava, the heating that heats up is opened and is stirred simultaneously, makes to dissolve, in 60 ℃～90 ℃ left and right after Cera Flava dissolves completely, the phospholipid, the glycerol triacetate that add successively formula ratio, stir, be cooled to room temperature and obtain emulsion, get the coenzyme Q10 of formula ratio, join in above-mentioned emulsion, stirring, it is standby to obtain medicinal liquid.By the above-mentioned medicinal liquid access softgel shell rubber configuring, through encapsulating machine, be pressed into ball, dry, obtain.
Embodiment 4
Formula forms:
Preparation method:
The almond oil of formula ratio is placed in to material-compound tank, add Cera Flava, the heating that heats up is opened and is stirred simultaneously, makes to dissolve, after stirring in 60 ℃～90 ℃ left and right, the phospholipid, the glycerol that add successively formula ratio, stir, be cooled to room temperature and obtain emulsion, get the coenzyme Q10 of formula ratio, join in above-mentioned emulsion, stirring, it is standby to obtain medicinal liquid.By the above-mentioned medicinal liquid access softgel shell rubber configuring, through encapsulating machine, be pressed into ball, dry, obtain.
Embodiment 5
Formula forms:
Preparation method:
The Oleum Arachidis hypogaeae semen of formula ratio, Oleum Brassicae campestris are placed in to material-compound tank, the heating that heats up is opened and is stirred simultaneously, when temperature reaches 60 ℃～90 ℃ of left and right, the phospholipid, the propylene glycol that add successively formula ratio, stir, be cooled to room temperature and obtain emulsion, get the coenzyme Q10 of formula ratio, join in above-mentioned emulsion, stirring, it is standby to obtain medicinal liquid.By the above-mentioned medicinal liquid access softgel shell rubber configuring, through encapsulating machine, be pressed into ball, dry, obtain.
Comparative example
Formula forms:
Wherein, the natural Vitamin E that vitamin E is 1000IU/g.
Preparation method:
The Semen Maydis oil of formula ratio is placed in to material-compound tank, and the heating that heats up is opened and is stirred simultaneously, adds successively vitamin E, the Cera Flava of formula ratio, stirs, and adds the coenzyme Q10 of formula ratio, and stirring, it is standby to obtain medicinal liquid.By the above-mentioned medicinal liquid access softgel shell rubber configuring, through encapsulating machine, be pressed into ball, dry, obtain.
Experimental example 1, stability test
Get respectively that coenzyme Q 10 soft capsule prepared by embodiment 1-5 and comparative example carries out product characteristics, disintegration, related substance, (content refers to the result that measured value is surveyed with respect to inventory to content measuring, the scope allowing is 90%-110%), test result is as shown in table 1.
Table 1
The long-term placement after 24 months of coenzyme Q 10 soft capsule prepared by above-described embodiment 1-5 and comparative example carried out product characteristics, disintegration, related substance, content measuring again, and test result is as shown in table 2.
Table 2
Experimental result:
1, the coenzyme Q 10 soft capsule process study on the stability of long-term 24 months that prepared by embodiment 1-5, the value of character, disintegration, related substance is all up to specification; Content is without significant change.
2, the coenzyme Q 10 soft capsule process study on the stability of long-term 24 months that prepared by comparative example, character is without significant change, and disintegration, related substance increase obviously, and content reduction degree is greater than embodiment 1-5.
Above result shows, the stability of coenzyme Q 10 soft capsule prepared by embodiment 1-5 is better than comparative example.
Experimental example 2, dissolution test
Get embodiment 1-5 and comparative example coenzyme Q 10 soft capsule, press < < Chinese Pharmacopoeia > > appendix X C dissolution determination method the second method, isopropyl alcohol-0.5% Tween 80 solution (25:75) 500ml of take is solvent, rotating speed is 150 revs/min, in the time of 45 minutes, getting 10ml solution filters, press < < Chinese Pharmacopoeia > > appendix IV A ultraviolet visible spectrophotometry and measure absorbance, calculate dissolution, its result is as shown in table 3.
Table 3
From result, the coenzyme Q 10 soft capsule of embodiment 1-5 in the time of 45 minutes dissolution higher than contrast groups.
Experimental example 3, content uniformity test
Get each 10 of embodiment 1-5 and comparative example coenzyme Q 10 soft capsules, measure every content, calculate the uniformity of dosage units of each sample, result represents with A+1.80S.Its result is as shown in table 4.
Table 4
Result shows, the embodiment 1-5 coenzyme Q 10 soft capsule uniformity is significantly better than comparative example.
Claims (8)
1. a coenzyme Q 10 soft capsule, in capsule, the component of content and mass percent thereof are composed as follows:
Coenzyme Q10 1-20
Diluent 30-95
Emulsifying agent 1-50
Cosolvent 1-30
Each component dosage sum is 100%; Described diluent is selected from one or more in soybean oil, Oleum Brassicae campestris, Oleum Ricini, almond oil, Semen Maydis oil, Oleum Gossypii semen, olive oil, Oleum Arachidis hypogaeae semen, Oleum Helianthi, Oleum sesami;
Described emulsifying agent is selected from one or more the mixing in phospholipid or phospholipid and following material:
Cera Flava, glyceryl monostearate, Brazil wax, polyglycol ether, arabic gum, albumin;
Described cosolvent is selected from one or more in glycerol triacetate, sodium lauryl sulphate, polysorbate 20, polysorbate 40, polysorbate 60, polyoxyethylene sorbitan monoleate, Macrogol 200, Liquid Macrogol, PEG400, Macrogol 600, Polyethylene Glycol 800, cetomacrogol 1000, polyethylene glycol 1500, Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, ethanol, isosorbide dimethyl ether, glycerol and propylene glycol.
2. coenzyme Q 10 soft capsule according to claim 1, is characterized in that, in described capsule, the component of content and mass percent thereof are composed as follows:
Coenzyme Q10 3-15
Diluent 60-85
Emulsifying agent 2-20
Cosolvent 2-15
Each component dosage sum is 100%.
3. coenzyme Q 10 soft capsule according to claim 1, is characterized in that, in every coenzyme Q 10 soft capsule, the component of content and mass content thereof are as follows:
Coenzyme Q10 20mg
Oleum Arachidis hypogaeae semen 400mg
Phosphatidase 15 0mg
Polyglycol ether 10mg
Glycerol 15mg.
4. coenzyme Q 10 soft capsule according to claim 1, is characterized in that, in every coenzyme Q 10 soft capsule, the component of content and mass content thereof are as follows:
Coenzyme Q10 35mg
Olive oil 380mg
Phospholipid 70mg
Cera Flava 10mg
Polyoxyethylene sorbitan monoleate 22.5mg.
?
5. coenzyme Q 10 soft capsule according to claim 1, is characterized in that, in every coenzyme Q 10 soft capsule, the component of content and mass content thereof are as follows:
Coenzyme Q10 22.5mg
Soybean oil 390mg
Phospholipid 80mg
Glyceryl monostearate 15mg
Glycerol triacetate 25mg.
6. coenzyme Q 10 soft capsule according to claim 1, is characterized in that, in every coenzyme Q 10 soft capsule, the component of content and mass content thereof are as follows:
Coenzyme Q10 50mg
Oleum Arachidis hypogaeae semen 300mg
Oleum Brassicae campestris 50mg
Phospholipid 90mg
Isosorbide dimethyl ether 16mg.
7. a preparation method for the coenzyme Q 10 soft capsule described in claim 1-6 any one, comprises the following steps:
(1) diluent of formula ratio is placed in to material-compound tank, adds emulsifying agent, heating makes emulsifiers dissolve and stirs;
(2) under step (1) solution temperature, add again the cosolvent of formula ratio, after stirring, be cooled to room temperature, obtain emulsion;
(3) coenzyme Q10 of getting formula ratio joins in the emulsion that step (2) makes, and stirs, and obtains the content medicinal liquid in capsule;
(4) gained content medicinal liquid in step (3) and softgel shell rubber are pressed into ball through encapsulating machine, dry, obtain.
8. the preparation method of coenzyme Q 10 soft capsule according to claim 7, is characterized in that, in step (1), heating for dissolving temperature is 60-90 ℃.
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| CN109922793A (en) * | 2016-09-06 | 2019-06-21 | 雅典娜股份公司 | The dietary supplements of poorly water-soluble and the dissolving method of pharmaceutically active agents |
| CN110967430A (en) * | 2019-12-25 | 2020-04-07 | 上海普康药业有限公司 | Method for measuring dissolution curve of coenzyme Q10 capsule |
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| CN113546062A (en) * | 2021-08-05 | 2021-10-26 | 上海健康医学院 | Vitamin D soft capsule and preparation method thereof |
| CN117502646A (en) * | 2023-11-29 | 2024-02-06 | 航天神舟生物科技集团有限公司 | High-content water-soluble coenzyme Q10 composition and preparation method thereof |
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| CN105167105A (en) * | 2014-06-04 | 2015-12-23 | 百岳特生物科技（上海）有限公司 | Composition having coenzyme Q10 and preparation method thereof |
| CN105167105B (en) * | 2014-06-04 | 2017-12-12 | 百岳特生物科技（上海）有限公司 | A kind of constituent with Co-Q10 and preparation method thereof |
| US10905657B2 (en) | 2015-06-12 | 2021-02-02 | Indena S.P.A. | Solid dispersions of Coenzyme Q10 |
| CN105963254B (en) * | 2016-06-28 | 2019-03-22 | 北京素维生物科技有限公司 | A kind of coenzyme Q 10 pharmaceutical composition and its preparation process |
| CN105963254A (en) * | 2016-06-28 | 2016-09-28 | 北京素维生物科技有限公司 | Coenzyme Q10 pharmaceutical composition and preparation process thereof |
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| CN112370442A (en) * | 2020-12-15 | 2021-02-19 | 浙江工业大学 | Coenzyme Q10 drug delivery system and preparation method thereof |
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