CN1230191C - Health care combination of propolis for reducing blood sugar and fat as well as method for mfg. its capsule - Google Patents
Health care combination of propolis for reducing blood sugar and fat as well as method for mfg. its capsule Download PDFInfo
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Abstract
The present invention discloses a bee glue health-care composition for reducing blood sugar and blood fat, which is composed of the following components of the proportion by weight: 26 to 41% of bee glue, 20 to 37% of royal jelly dried powder, 9 to 32% of sunflower seed oil, 5 to 10% of liquorice extract and 5 to 10% of plant essence, wherein the plant essence is one of gingko extract or ganoderma lucidum spore powder or a mixture of the gingko extract and the ganoderma lucidum spore powder of arbitrary proportion. Borax occupying 0.5% of the total weight of the composition and beeswax occupying 1.5% of the total weight of the composition can also be emulsified step by step, then, the emulsified borax and beeswax are filtered to obtain solid, and finally, gelatin capsules are used for preparing soft capsule products. The present invention solves the problems of high heavy metal content, high irritability rate, lower effective content, etc. of the existing unilateral medicament products, and has the advantages of low heavy metal content, low irritability rate, high effective component content, reasonable compounding, high biological availability, no side effect, good treatment effect, abundant nutrient component, etc. The bee glue health-care composition can be widely used for maintaining the functions of livers and kidneys, reducing blood fat and blood sugar, treating diabetes and preventing and treating complication.
Description
Technical field the present invention relates to a kind of bee-glue for lowering blood-sugar Antilipemic health compositions and capsular manufacture method thereof, more particularly, relate to a kind of with the propolis be primary raw material and add Lac regis apis and Chinese medicine in order to the health composition and the capsular manufacture method thereof of hypoglycemic.
Background technology is well-known, propolis is that Apis is adopted propolis, warp-wise wherein inserts the colloid substance that Apis lingual gland, wax wax secretions mixed catalytic process, be Apis with it as environment purification, diseases prevention, unique material of curing the disease, main component wherein is flavone compound, obedient vinyl compound and enzyme etc.
In the prior art, existing nearly 5,000 years application history in the west, as far back as ancient Egypt, people just make mummy with carpenter bee glue as antiseptic; During the World War II, countries such as English, Russia just are used as propolis as antibiosis and usually use.Along with development of science and technology, the application of propolis also is used in the treatment of difficult miscellaneous diseases such as cancer, diabetes, cardiovascular and cerebrovascular disease more widely, and obtains mysterious effect.Taiwan propolis academic authority-Ou Benli points out: propolis is known as the medicament that has no side effect fully in each difficult miscellaneous diseases of treatment, also is mysterious cancer medication by envelope.And point out that " propolis " is only the comprehensive expression of person of naturopathy, tool surmounts the effect of modern medical service.The China honeybee is treated authority-professor Wang Jinyong and writes articles: have blood sugar reducing function in the time of propolis blood fat reducing preventing arteriosclerosis, and can improve activity of islet cells, can within a short period of time fast quick-recovery blood glucose.Minister report in the island in the Japan: propolis is to the quick restitution of diabetes tool.China's propolis academic authority-Liu Fu placard is led: have 55% diabetics (I type and II type) to take propolis on former treatment basis, high blood glucose progressively is reduced; Have patient's (I type) of 39% taking propolis about a week, blood glucose target just can recover normally, and normal person's blood glucose is not had influence.In the prior art,, be bee glue preparation product both at home and abroad, do not find the compound formulation products of propolis as yet than single component though there is numerous businessmans exploitation propolis product to promote the well-being of mankind.The single preparations of ephedrine product has shortcomings such as content of beary metal height, irritated rate height, effective content are lower, thereby needs to improve.
Summary of the invention the objective of the invention is to overcome not to be had specific aim to treating correlative diseases in the prior art and provides a kind of to diabetes, the pointed health composition of hyperlipidemia, added " integration of edible and medicinal herbs " plant extract that can remove heavy-metal residual component in the human body and effectively reduce irritated rate, and solid content height, nutritional labeling abundant and have an effective health composition of hypoglycemic.
In order to achieve the above object, the invention provides following technical scheme: develop a kind of bee-glue for lowering blood-sugar Antilipemic health compositions, the composition of said composition and weight percentage are: propolis 26-41, Lac regis apis dry powder 20-37, safflower oil 9-32, Radix Glycyrrhizae extract 5-10, blood pressure and blood lipoid regulator 5-10, the mixture of any one that described blood pressure and blood lipoid regulator is Semen Ginkgo extrac or Ganoderma spore powder or two kinds of arbitrary proportions, described propolis is that Apis is adopted propolis, be that Apis inserts the Apis lingual gland in resin, the colloid substance that wax gland secretions forms, Lac regis apis dry powder is to adopt freezing and through the Lac regis apis of concentrate drying, safflower oil is the oils and fats that refines from Semen Flos Carthami, and Radix Glycyrrhizae extract is that the Radix Glycyrrhizae crude drug is through soaking, the active ingredient of concentrated extract, each composition fully mix and promptly get compositions.Studies have shown that: propolis has following five large effects: 1. antibiotic, antiinflammatory, granulation promoting, toxin expelling-the be described as material of the natural antibiosis of tool of occurring in nature; Free radical resisting, regulate metabolism, enhancement of SOD isoreactivity-the be described as Natural antioxidant (modern science proves: the propolis antioxidation is only second to vitamin E); 3. reinforced immunological improves the resistance of body and vis medicatrix naturae-be described as natural immunity reinforcing agent; 4. purify the blood, vessel softening improves blood circulation-be described as blood vessel street cleaner; 5. promotion cell regeneration is accelerated the damage body function and is recovered-be described as healthy protect god.Lac regis apis is a kind of biological activity height and the strong natural tonic of pharmacological action, have health care and pharmacology two-way function: 1, can promote protein and cell regeneration, activate aged cells, significantly improve the immunity of body, regulate metabolism, keep various balances, the hemopoietic function of excited bone marrow, improve the erythrocyte of human body, strengthen the heart and brain blood capillary; 2, blood vessel dilating, balancing blood pressure, blood sugar lowering, blood fat and cholesterol; 3, can increase the respiratory function of liver mitochondrion; 4, Lac regis apis is acidic materials, and propolis effect in sour environment is the strongest.Therefore, propolis and Lac regis apis compatibility have potentiation, and propolis has very strong antioxidation, can protect the activity of Lac regis apis.Safflower oil is rich in linoleic acid, oleic acid, palmitic acid, bioactive substances such as tocopherol, safflower oil is rich in linoleic acid 73%-85% and provides necessary fatty acid for human body, clinical trial proves: the safflower oil high density lipoprotein in the serum that can raise, thereby the drainage of the low density cholesterol in the increasing blood, make T-CHOL decline in the serum, reach the control hyperlipidemia, the arteriosclerosis that hypercholesterolemia causes, coronary heart disease, the diabetic complication that hypertension etc. are common, and propolis is emulsified in the safflower oil, be more conducive to digesting and assimilating of human body, play potentiation.Radix Glycyrrhizae extract mainly contains glycyrrhizin, multiple flavone compound, tonkabean spermin, cinnamic acid derivative and several amino acids.Have and coordinate substance metabolism, enhancing body adaptive capacity, poisonings such as medicine, food, interior metabolism product and bacteriotoxin are all had certain Detoxication, and effects such as antiulcer, antiinflammatory, antitumor and blood fat reducing are arranged adverse circumstances.Radix Glycyrrhizae extract not only plays potentiation but also can reduce the oral irritated rate of propolis, the property of medicine of gentle preparation in whole prescription.In sum, four kinds of components are used in aforesaid ratio, have synergism each other, have fabulous blood sugar lowering and effect for reducing blood fat.The two all has blood sugar regulation and blood fat Semen Ginkgo extrac and Ganoderma spore powder, and raise immunity can play potentiation, and its effect is basic identical, in compositions, add the two one or both of all add, all be fine.
The present invention's technical scheme preferably can also be: contain said composition gross weight 0.4%～0.6% Borax and 1%～2% mellisic auxiliary composition in the above-mentioned composition, described Cera Flava is the secretions of Apis wax gland.But the pH value of Borax balance preparation is got rid of the heavy metal that remains in human body and the propolis; But the Cera Flava stabilization formulations, the gentle property of medicine.Undoubtedly, all be very useful no matter contain the Borax and the Cera Flava that add described amount in the compositions of Semen Ginkgo extrac, Ganoderma spore powder one or both of to whether to improving the property of medicine and taking effect.
The method that the present composition is made capsule formulation is: use existing soft capsule, adopt substep emulsifying, detailed process is: described mixed liquor: A is prepared and handled in (1) as follows, quantitatively take by weighing each component, and earlier with propolis under-3--5 ℃ the temperature freezing at least 15 minutes and be crushed to 40 orders or more than, B again, the Polyethylene Glycol of getting composition total weight 25%-30% mixes with propolis powder, got I liquid at least 20 minutes in 68-75 ℃ of heating and stirring and emulsifying, naturally cooling, and C, the Cera Flava of getting quantitative safflower oil and composition total weight 1%～2% mix II liquid, be warming up to 70-75 ℃ and under this temperature and stirring and emulsifying at least 3 minutes, while D, the Borax of getting the glycerol of composition total weight 4%-6% and composition total weight 0.4%-0.6% mix III liquid, be warming up to 75-80 ℃, this liquid is mixed with II liquid, holding temperature 70-80 ℃ and stirring and emulsifying at least 3 minutes, with these two kinds of mixed liquors mix with I liquid IV liquid, naturally cooling, (2) are under 40-45 ℃ of temperature then, quantitatively add other each composition to IV liquid, stirring and emulsifying at least 20 minutes, filter with 100-150 order drainage screen, in the online capsule core material that gets, (3) fill capsule gets capsule product then; Described composition total weight is for only comprising the gross weight of propolis, Lac regis apis dry powder, safflower oil, Radix Glycyrrhizae extract, Semen Ginkgo extrac and Ganoderma spore powder.This health composition preferably is made into capsule, decomposes in view of the volatile and easy oxidation by air of the active ingredient of propolis in the compositions and Lac regis apis dry powder, removes to prepare promptly the clothes, must keep in Dark Place, so preferably make capsule.
Compared with prior art, the present invention has following tangible advantage: 1, the single preparations of ephedrine product is compared with combination propolis product of the present invention: (1) content of beary metal is low: the propolis raw material lead tolerance that the beekeeper gathers is too high, can not directly eat.Commercially available general propolis product content of beary metal height, bee-glue composition heavy metal of the present invention only contain the following heavy metal of 1ppm, and have added the natural materials that can remove heavy metal in the human body in prescription, have avoided the side effect of heavy metal to human body substantially fully; (2) irritated rate is low: propolis irritated crowd for oral administration is 3/10000ths, added " integration of edible and medicinal herbs " plant extract that can effectively reduce irritated rate in the bee-glue composition of the present invention, diabetics hypersensitive once appearred in other brand propolis products of taking that have, and allergic phenomena disappears behind the bee-glue composition of the present invention; (3) effective component content height: commercially available bee glue soft capsule contains solid content matter, and generally all less than 3.5%, effective solid content matter of bee-glue composition of the present invention is greater than 50%, and product efficacy is more powerful; (4) compatibility is reasonable: commercially available common propolis product is single component, this bee-glue composition is through studying, screen prescription repeatedly, determine with the propolis to be that monarch, royal jelly are that minister, several natural plants elite are that assistant makes, make the product P H-number be acid propolis pH value and be about 6.8, propolis is under sour environment, and effect is obviously strengthened; In addition, when this product has in " control support in conjunction with " prescription propolis and royal jelly tool therapeutical effect, its very rich nutrient contents remedied patient's too tight malnourished defective that produces of keeping on a diet at ordinary times again, body has increased nutrition, bring into play the effect of the treatment of medicine again better, this has demonstrated fully the marrow that the traditional Chinese medical science " is controlled and supported combination "; Moreover, effect tool specific aim, the therapeutic efficiency of traditional propolis product almost " is guaranteed to cure all diseases ", carries out compatibility at pathology of Diabetes Mellitus, the cause of disease, and bee-glue composition of the present invention has better curative effect to diabetics.2, bioavailability height: commercially available general propolis product is the ethanol preparation, medically, and diabetes, the cardiovascular and cerebrovascular vessel medication, not advocating with ethanol is carrier, bee-glue composition of the present invention is a hydrophilic oil solubility preparation, and, be more conducive to human consumption and absorb through the processing of emulsification pretreatment technology.3, bee-glue composition gum base of the present invention and the correlated advantage of traditional diabetes medicament: (1) traditional Western medicine is with strong points, but side effect, particularly hypoglycemia can occur.Propolis of the present invention has quick blood sugar reducing function, and tool activates islet cells, safeguards liver, renal function, and the function of liver, kidney decomposition glucose is strengthened, and alleviates the islets of langerhans burden, simultaneously hypoglycemia is also had a regulating action; (2) Drug resistance can appear after the general diabetes patient of traditional Western medicine took for a long time, effect is satisfactory for result not as taking the initial stage, can't guarantee that the diabetes patient controls euglycemia, propolis application Shi Shangshang does not at home and abroad find Drug resistance, propolis is the tool potentiation in clinical practice, when having 55% diabetes patient such as the former effect of taking medicine undesirable, increase the clothes propolis and can make blood glucose progressively normal.The application of propolis of the present invention then reflects better effect; (3) the good antiinflammatory promoting muscle growth functions of propolis tool of the present invention, this is that present diabetes medicament can't have both when the performance blood sugar reducing function simultaneously.Propolis of the present invention possesses good antiinflammatory granulation promoting effect when guaranteeing normal blood glucose regulation, this is the important measures of control glycosuria blood complication; (4) propolis of the present invention all has significant effect to blood fat, blood pressure in blood sugar lowering, this be Western medicine can't chase after than, also be the important foundation of diabetes control complication.
The clinical case of following the application of the invention product further specifies its concrete effect: take bee-glue composition soft capsule of the present invention, general patient obeys 2-3 time every day, each two, this compositions of meter clothes 2-3g, taking 3 months continuously is a course of treatment, wherein: 100 routine diabeticss have 96 routine blood glucose that in various degree decline is arranged, fall up 9.6mmol/l, minimum 0.8mmol/l, average 3.82mmol/l, effective percentage 96%; In addition, 42 routine hypertension, hyperlipemic patients are taken, and wherein hyperpietic's 89% subjective symptom is obviously improved, and 83.4% blood pressure reduces, average shrinkage pressure drop 25-40mmHg, and diastole pressure drop 10mmHg is completely without untoward reaction; Hyperlipemic patients cholesterol reducing total effective rate 70.6%, triglyceride reducing total effective rate 87.3%.Below be concrete case:
Feng Deming, the man, 45 years old, people from Chengdu, Sichuan, type ii diabetes, medical history 5 years, treatments such as glyburide, precious stilbene in the clothes all the time, effect is undesirable always, glycemic control repeatedly, take thirsty before this compositions, polydipsia, polyuria, insomnia, constipation, symptom such as weak, on original treatment basis, add present embodiment 1 compositions (promptly joining instant-drink) day clothes 2 times, each 1g, above-mentioned symptom is clearly better after one month, fasting glucose is reduced to 6.1mmol/l from 9.14mmol/l, and the blood glucose fall reaches 33%, and glucose in urine is before take ++ ++ reduce to+.
Ceng Zhiming, man, 43 years old, the ShenZhen,GuangDong people, type ii diabetes, medical history 5 years, all the time the thing of taking medicine treatment, take symptoms such as the preceding thirst and liking drink of this compositions, constipation, blood glucose 12.9mmol/l, glucose in urine ++ ++, 1 composition soft every day of clothes present embodiment 2 times, each two (pure medicine 1g), fasting glucose 6.3mmol/l after 15 days, glucose in urine reduce to+.
Huang Aizhen, woman, 57 years old, Jiangshan of Zhejiang Province people, hypertension, coronary heart disease, medical history 10 years, main chat uncomfortable in chest, head rises, insomnia, symptom such as weak, blood pressure 105/170mmHg on inspection, T-CHOL, glyceride all are higher than normal range, 5 composition soft every days of clothes present embodiment 3 times, each two and pure medicine 1.5Kg, blood pressure is 85/120mmHg after three months, T-CHOL, triglyceride are all in normal range.
By specific embodiment the present invention is carried out more detailed description below the specific embodiment:
Embodiment 1
Take by weighing each composition by each composition weight of following compositions: propolis micelle 28Kg, Lac regis apis dry powder 20Kg, safflower oil 10Kg, Radix Glycyrrhizae extract 5Kg, add Semen Ginkgo extrac 3Kg and Ganoderma spore powder 5Kg again, fully mix, take by weighing every 1g and get final product with the lucifuge bag hermetic package.
Embodiment 2
Take by weighing each composition by each composition weight of following compositions: propolis micelle 40Kg, Lac regis apis dry powder 22Kg, safflower oil 20Kg, Radix Glycyrrhizae extract 6Kg adds Semen Ginkgo extrac 8Kg again, fully mixes, and takes by weighing every 1g and gets final product with the lucifuge bag hermetic package.
Embodiment 3
Weight parcel capsule process with embodiment 2 prescription is as follows: prepares and handles described mixed liquor: A as follows, quantitatively takes by weighing each component, and earlier with propolis under-5 ℃ temperature freezing 20 minutes and be crushed to 40 order powdereds; B, the Polyethylene Glycol of 30Kg and propolis powder are mixed, put into 70 ℃ of heating of water-bath constant temperature, and start the emulsification pretreatment machine and made propolis emulsifying get I liquid in 30 minutes, lower the temperature naturally, emulsive propolis is moved to another container, be cooled to 45 ℃ naturally; C, get the Cera Flava of safflower oil and 2Kg weight, put into water-bath, 70 ℃ of intensification and constant temperature, starting the emulsification pretreatment machine made propolis emulsifying get II liquid in 5 minutes, while D, the Borax of getting the glycerol of 5Kg weight and 0.5Kg weight mix III liquid, heat up 80 ℃, this liquid is mixed with II liquid, 75 ℃ of holding temperatures also start emulsification pretreatment machine emulsifying 5 minutes, with these two kinds of mixed liquors mix with I liquid IV liquid, naturally the cooling, (2) are under 45 ℃ of temperature then, quantitatively add the royal jelly lyophilized powder to IV liquid, the Radix Glycyrrhizae extract, Semen Ginkgo extrac and the sub-powder of Ganoderma bud, stirring and emulsifying 30 minutes is filtered with 120 order rustless steel drainage screens, in the online capsule core material that gets, (3) get the gelatine capsule casing material then, use the core material fill, get the capsule formulation product.
Embodiment 4-8 capsule formulation manufacture method is with example 3, and prescription is as table 1.
Table 1 is made capsule formulation prescription one and is pulled list position: Kg
| The example composition | 4 | 5 | 6 | 7 | 8 |
| Propolis | 26 | 30 | 33 | 40 | 36 |
| Lac regis apis dry powder | 22 | 25 | 32 | 27 | 22 |
| Safflower oil | 25 | 10 | 30 | 23 | 28 |
| Radix Glycyrrhizae extract | 7 | 5 | 5 | 8 | 6 |
| Semen Ginkgo extrac | 8 | 5 | 3 | 5 | |
| Ganoderma spore powder | 5 | 5 | 3 | 2 | |
| Cera Flava | 1.2 | 1.3 | 1.6 | 1.5 | 1.5 |
| Polyethylene Glycol | 26 | 20 | 28 | 28 | 30 |
| Glycerol | 5 | 4 | 5 | 5 | 5 |
| Borax | 0.5 | 0.5 | 0.5 | 0.55 | 0.55 |
In the raw material of aforementioned each embodiment: Semen Ginkgo extrac is the lyophilized powder of Folium Ginkgo extract, and Guangzhou Australia woods chemical industry company limited is produced; Radix Glycyrrhizae extract is produced by Baoji gloomy plant chemical industry company limited of gold; The sub-powder of Ganoderma bud is produced by Mount Taishan, Tai big peace Ganoderma company limited; Gelatin is produced by Danyang City, Jiangsu pharmaceutcal corporation, Ltd.
Claims (3)
1, a kind of bee-glue for lowering blood-sugar Antilipemic health compositions, it is characterized in that: the composition of compositions and weight percentage are:
Propolis 26-41
Lac regis apis dry powder 20-37
Safflower oil 9-32
Radix Glycyrrhizae extract 5-10
Blood pressure and blood lipoid regulator 5-10
The mixture of any one that described blood pressure and blood lipoid regulator is Semen Ginkgo extrac or Ganoderma spore powder or two kinds of arbitrary proportions, described propolis is that Apis is adopted propolis, be that Apis inserts the colloid substance that Apis lingual gland, wax gland secretions form in resin, Lac regis apis dry powder is to adopt freezing and through the Lac regis apis of concentrate drying, safflower oil is the oils and fats that refines from Semen Flos Carthami, Radix Glycyrrhizae extract be the Radix Glycyrrhizae crude drug through soak, the active ingredient of concentrated extract, each composition fully mixes and promptly gets compositions.
2, compositions according to claim 1 is characterized in that: also add said composition gross weight 0.4%～0.6% Borax and 1%～2% mellisic auxiliary composition, described Cera Flava is the secretions of Apis wax gland.
3, the manufacture method of the capsule preparations of claim 1 or 2 described compositionss is used existing soft capsule, it is characterized in that: adopt substep emulsifying, detailed process is:
(1) prepare and handle described mixed liquor as follows:
A, quantitatively take by weighing each component, and earlier with propolis under-3--5 ℃ the temperature freezing at least 15 minutes and be crushed to 40 orders or more than, again
B, the Polyethylene Glycol of getting composition total weight 25%-30% mix with propolis powder, in 68-75 ℃ of heating and stirring and emulsifying at least 20 minutes I liquid, lower the temperature naturally, and
C, the Cera Flava of getting quantitative safflower oil and composition total weight 1%～2% mix II liquid, be warming up to 70-75 ℃ and under this temperature and stirring and emulsifying at least 3 minutes, simultaneously
The Borax of D, the glycerol of getting composition total weight 4%-6% and composition total weight 0.4%-0.6% mix III liquid, be warming up to 75-80 ℃, this liquid is mixed with II liquid, holding temperature 70-80 ℃ and stirring and emulsifying at least 3 minutes, with these two kinds of mixed liquors mix with I liquid IV liquid, naturally cooling, then
(2) under 40-45 ℃ of temperature, quantitatively add other each composition to IV liquid, stirring and emulsifying at least 20 minutes is filtered with 100-150 order drainage screen, in the online capsule core material that gets, then
(3) fill capsule gets capsule product;
Described composition total weight is for only comprising the gross weight of propolis, Lac regis apis dry powder, safflower oil, Radix Glycyrrhizae extract, Semen Ginkgo extrac and Ganoderma spore powder.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03113649 CN1230191C (en) | 2003-01-20 | 2003-01-20 | Health care combination of propolis for reducing blood sugar and fat as well as method for mfg. its capsule |
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| CN 03113649 CN1230191C (en) | 2003-01-20 | 2003-01-20 | Health care combination of propolis for reducing blood sugar and fat as well as method for mfg. its capsule |
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| CN1230191C true CN1230191C (en) | 2005-12-07 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100340250C (en) * | 2005-06-09 | 2007-10-03 | 周云川 | Composite propolis soft capsule |
| CN101120750B (en) * | 2006-08-10 | 2012-07-18 | 宋涛 | Method for preparing ginkgo bee product |
| CN102166013A (en) * | 2011-03-03 | 2011-08-31 | 王海林 | Health-care food capable of lowering blood pressure and processing method thereof |
| CN102823792B (en) * | 2012-08-28 | 2013-09-11 | 安徽省王巢食品有限公司 | Soft propolis astragalus mongholicus capsule and preparation method thereof |
| CN103815395A (en) * | 2013-12-25 | 2014-05-28 | 伊犁百信草原蜂业有限责任公司 | Propolis-safflower oil soft capsule and preparation method thereof |
| CN104489444A (en) * | 2014-12-22 | 2015-04-08 | 黑龙江农垦东北黑蜂开发有限公司 | Propolis-royal jelly soft capsule |
| JP2022074486A (en) * | 2020-11-04 | 2022-05-18 | 株式会社山田養蜂場本社 | Sarcopenia improver |
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