JPH0278613A - Soft capsule containing essential oil - Google Patents

Abstract

PURPOSE:To obtain a capsule resistant to the lowering of solubility and discoloration with time, composed of gelatin and a polypeptide and containing an aldehyde-containing natural vegetable oil such as cinnamon oil or anise oil and an essential oil extract reactive to the amino group of gelatin. CONSTITUTION:The soft gelatin capsule is composed of a capsule wall made of gelatin compounded with 15-70wt.% (preferably 20-50wt.%) of a polypeptide and is filled with an oil such as cinnamon oil, anise oil, clove oil, peppermint oil, ginger oil, cardamom oil, lemon oil, citrus oil or l-menthol. Preferably, the polypeptide has a molecular weight of 5,000-10,000 and is used in the form of powder. The gelatin wall of the capsule produced by the above process is resistant to the lowering of solubility and the discoloration with time. The capsule is produced by mixing gelatin with a polypeptide, swelling the mixture with purified water and forming a capsule by a capsule-forming machine using cinnamon oil, etc., as a contact.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to soft gelatin capsules. More specifically, the present invention relates to soft gelatin capsules that prevent gelatin coatings from becoming insolubilized and exhibit stable solubility.

[Prior Art] Conventionally, as a technique for preventing gelatin film from becoming insolubilized, there has been a method of blending various additives with gelatin (Japanese Patent Publication No. 60-9).
No. 011, Japanese Patent Publication No. 57-3008, Japanese Patent Publication No. 59-39834) and a method using so-called modephite gelatin in which the amino groups in gelatin molecules are blocked with organic acids (Japanese Patent Publication No. 50-106876). Publication No.) is known.

[Problems to be Solved by the Invention] However, the types of contents, such as cinnamon oil, fennel oil, clove oil, pepper oil, ginger oil, ginger oil, lemon oil, spruce oil, l-menthol, etc. If a compound that easily reacts with the amino groups of gelatin is contained, the solubility of the gelatin film may deteriorate over time or the gelatin film may change color.

[Means for Solving the Problems] In order to prevent deterioration of solubility and discoloration of the gelatin film, the present inventors have incorporated various additives such as surfactants and plasticizers into gelatin. As a result of examining the situation of insolubilization and discoloration, it was discovered that soft gelatin capsules prepared by powdering a polypeptide and blending it with gelatin met the objective, and based on this knowledge, the present invention was completed.

The present invention contains as contents one or more of the group consisting of cinnamon bark oil, fennel oil, clove oil, mustard oil, ginger oil, ginger oil, lemon oil, spruce oil, l-menthol, and contains polypeptides. It is a soft gelatin capsule consisting of a film containing 15 to 70% by weight of gelatin.

In order to prevent deterioration of solubility and discoloration over time, it is preferable to use the polypeptide of the present invention by powdering the polypeptide with a molecular weight of s, ooo to ooo, and the amount of the polypeptide to gelatin is as follows: The content is 15 to 70% by weight, more preferably 20 to 50% by weight.

For the production method of the present invention, conventional methods for producing soft capsules such as a punching method, a dropping method, and a dipping method can be used, but a rotary one-type punching method is preferable. Furthermore, depending on the contents, a method of producing a so-called seamless capsule without a seam by a dropping method is preferable.An example of the production method of the present invention is as follows.

Gelatin and polypeptide are mixed, an appropriate amount of purified water is added and stirred, and then left to stand for 10 to 20 minutes to allow swelling. This is heated to a temperature of 60°C and dissolved to form a uniform aqueous gelatin solution. This gelatin aqueous solution is defoamed, and a film composition is encapsulated using a capsule making machine, with contents of an aldehyde-containing natural vegetable oil such as cinnamon oil and an essential oil extract that easily reacts with gelatin amino groups. The capsules thus obtained are dried for 16 to 60 hours in a production room controlled at a temperature of 23° C. and a humidity of 40% to form a molded product.

In addition, the soft capsules of the present invention have gelatin as the main base, and a gelatin solution is prepared by adding glycerin, D-sorbitol, or a preservative as a plasticizer, as appropriate, to form a film composition. You can also.

[Effects of the Invention] The gelatin capsule of the present invention does not become insolubilized even when it contains aldehyde-containing natural vegetable oils such as silicone oil and essential oil extracts that easily react with the amino groups of gelatin.

In addition, the gelatin capsules do not deteriorate in solubility or change color over time.

[Example] The present invention will be further specifically explained by giving Examples and Test Examples.

Examples 1 to 10 Table 1 (Film composition) Gelatin (molecular weight 100.000) and polypeptide powder [trade name: water-soluble gelatin U (Nitta Gelatin Co., Ltd.)] were blended in the proportions shown in Table 1, totaling 1 kg. After shaking and mixing in a polyethylene bag with a capacity of 2,
Add 2,500 g of purified water (25°C) to the solution tank equipped with a defoaming device, stir, then let stand at 60°C for 10 minutes to dissolve, and stir while reducing the pressure inside the tank to form a homogeneous aqueous solution. did. A film composition was prepared using this aqueous solution as a film base.

Table 2 This film composition was prepared using a capsule making machine (unexamined Japanese Patent Application Publication No. 2003-100000) using the contents of the formulation shown in Table 2 prepared in advance (prepared by adding essential oil components as crude drugs to the base and stirring uniformly). 1986
-14915 to 14954).

The capsules thus obtained are dried for about 6 hours in a manufacturing room controlled at a temperature of 23°C and a humidity of 40%, and then dried for 48 hours in a shelf-type dehumidifying dryer (temperature of 23°C and humidity of 40% or less) to form a molded product. did.

Test example 1 (disintegration test, discoloration status, film strength) (sample) Specimens 1 to 10: 20 capsules each of Examples 1 to 10.

Control sample: Same contents, same capsule manufacturing machine and drying conditions as Example, 1 kg of gelatin and 2.5 kg of purified water.
20 capsules with a film composition of g.

(Test method) The disintegration test immediately after manufacture was carried out in accordance with the 11th edition of the Japanese Pharmacopoeia, General Test Method 38, Disintegration Test Method (Operating method for capsules).

The degree of disintegration after one month was determined by placing the sample in a glass bottle (with a cap) and leaving it for one month at a temperature of 40°C and humidity of 75%, then removing the sample and measuring the degree of disintegration immediately after manufacture. .

The film strength is expressed as the average breaking strength when crushed at a rate of 6 [for 1 minute] using a rheometer (NMR-2030D-D model, manufactured by Fudo Kogyo Co., Ltd.). The 20 capsules used had an inner diameter of s, o immediately after production.
A film with a film thickness of 0.211H was used.

(result) It is shown in Table 3.

Test Example 2 (Disintegration test and discoloration test) (Sample) Capsule 620 with the same contents as in Example and the film composition shown in Table 4
Individual.

(Test method) Same as Test Example 1.

(result) It is shown in Table 5.

In order to prevent deterioration of solubility and discoloration of gelatin film,
Although modephite gelatin, an antioxidant, a surfactant, and a plasticizer were mixed, a fully satisfactory capsule could not be obtained.

Table 5

Claims (1)

[Claims] 1) Cinnamon oil, fennel oil, clove oil, peppermint oil,
Ginger oil, ginger oil, lemon oil, spruce oil,
Contains one or more members of the group consisting of l-menthol, and contains polypeptide at a ratio of 15% to gelatin.
Soft gelatin capsules consisting of a film containing ~70% by weight.