CN110338423A - A kind of health food for the pre- preventing bone rarefaction of the middle-aged and the old - Google Patents

A kind of health food for the pre- preventing bone rarefaction of the middle-aged and the old Download PDF

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Publication number
CN110338423A
CN110338423A CN201810305035.4A CN201810305035A CN110338423A CN 110338423 A CN110338423 A CN 110338423A CN 201810305035 A CN201810305035 A CN 201810305035A CN 110338423 A CN110338423 A CN 110338423A
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CN
China
Prior art keywords
vitamin
health food
content
folic acid
calcium
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Pending
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CN201810305035.4A
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Chinese (zh)
Inventor
于多
白洁
张磊
王滨燕
徐希平
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AUSA PHARMED Ltd
BEIJING AOSA MEDICINE RESEARCH CENTRE Co Ltd
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AUSA PHARMED Ltd
BEIJING AOSA MEDICINE RESEARCH CENTRE Co Ltd
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Priority to CN201810305035.4A priority Critical patent/CN110338423A/en
Publication of CN110338423A publication Critical patent/CN110338423A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The present invention provides one kind by vitamin A, vitamin K, vitamin B12, folic acid and appropriate auxiliary material composition health food, it is 10~100 μ g, vitamin B that wherein vitamin A content, which is 250~800 μ g, Wei Shengwei K contents,12Content is 5~20 μ g, and folate content is 200~800 μ g.The invention has the advantages that selected function related vitamin, prescription is scientific, reasonable, for mid-aged population, the pre- preventing bone rarefaction of emphasis；Have effects that synergistic effect between each composition, embodies accurate nutritional characteristic.

Description

A kind of health food for the pre- preventing bone rarefaction of the middle-aged and the old
Technical field
The present invention relates to a kind of health foods, more precisely, prevent sclerotin the present invention relates to a kind of couple of middle-aged and the old and dredge Loose disease has the health food for assisting protective effect.
Technical background
With Chinese population aging, some disease incidence for increasing related degenerative disease with the age also increase therewith, Such as osteoporosis.Osteoporosis is a kind of systemic disease characterized by bone brittleness increases and fracture easily occurs, doctor Be presented with bone amount in skeletal system unit volume is reduced, bone tissue microstructure is abnormal etc..Report from the World Health Organization Announcement shows in 50 years old or more the old man in the whole world, and 1/3 women and 1/5 male will receive the threat of osteoporosis.China is in the world On occupied the first place of patients with osteoporosis quantity, patients with osteoporosis increases 300% between Past 30 Years.Recent statistics The results show that China's sufferers of osteoporosis face is up to 90,000,000, wherein 50 years old or more women's disease incidence is more than 50%.
Currently, the health food for " increasing bone density " in the market is substantially divided to two classes: one kind is the health food of calcic, is logical It crosses direct supplement calcium and reaches and increase bone density purpose, this kind of health food mainly promotes the suction of calcium by vitamine D3 It receives, absorption excessively be easy to cause the health problems such as calcium disorder, muscle bone pain, and the intake of calcium is excessively high, leads to calcium phosphorus ration It is unbalance, so as to cause a series of sclerotin and intestinal absorption problem；It is another kind of to be free from calcium or the health care not for the purpose of replenishing the calcium Food is to promote the absorption of calcium to increase bone density this purpose, such as isoflavones, sulphur to reach by adjusting endocrine Aching and limp ossein.This kind of health food is mainly inherent adjusting, but calcium insufficiency of intake is equally problem, and has certain side effect (stimulate stomach lining, cause constipation etc.).Therefore, it invents and a kind of does not cause that calcium disorder, that there are few the promotion skeletal systems of side effect is strong The health food of health is particularly important.
Summary of the invention
The purpose of the present invention is to provide a kind of couple of middle-aged and the old to prevent the health care food that osteoporosis has facilitation Product.
To achieve the goals above, the invention adopts the following technical scheme:
A kind of couple of middle-aged and the old prevents the health food that osteoporosis has facilitation, consists of the following compositions:
(1) vitamin A
(2) vitamin K
(3) folic acid
(4) vitamin B12
(5) auxiliary material.
In above-mentioned health food, vitamin A content is 250~800 μ g, and vitamin K content is 10~100 μ g, folic acid Content is 200~800 μ g, vitamin B12Content is 5~20 μ g.
Preferably, health food of the present invention, vitamin A content be 600~800 μ g, vitamin K content be 35~ 100 μ g, folate content are 400~600 μ g, vitamin B12Content is 5~10 μ g.
In the present invention, the folic acid includes folic acid, 5-methyltetrahydrofolate, formyl tetrahydrofolic acid, folinic acid, Zuo Yaye Sour calcium etc. includes artificial synthesized and plant extract source various forms folic acid.
Health food of the present invention can be made into conventional tablet, chewable tablet, soft capsule, hard capsule, pulvis and The peroral dosage forms such as granule.
In the present invention, the auxiliary material be selected from filler (dispersing agent), suspending agent, wetting agent, adhesive, disintegrating agent, The combination of one or more of lubricant, corrigent, stabilizer, embedded object, coating pre-mixing agent, edible pigment.
Wherein, filler (dispersing agent) of the present invention includes starch, soluble starch, dextrin, maltodextrin, Ma Ling Sweet potato starch, cornstarch, wheaten starch, D-mannital, calcium monohydrogen phosphate, calcium phosphate dibasic anhydrous, maltose, xylitol, sorb Sugar alcohol, microcrystalline cellulose, isomaltoketose, milk powder, low-substituted hydroxypropyl cellulose, sucrose, glucose, lactose, pregelatinized starch, The one or more of edible vegetable oil, polyethylene glycol etc..
Suspending agent of the present invention include beeswax, insect wax, lecithin, glycerin monostearate, ethyl cellulose etc. its One or more of, the wetting agent includes purified water and ethyl alcohol, the adhesive include hydroxypropyl methyl cellulose, Povidone, hydroxypropylcellulose, carmethose, starch, methylcellulose, ethyl cellulose, gelatin, polyethylene glycol, pre- glue It is one of or several to change starch, sucrose, glucose etc..
Disintegrating agent of the present invention includes starch, carboxyrnethyl starch sodium, crospovidone, cross-linked carboxymethyl cellulose sodium, low Replace hydroxypropylcellulose, sodium bicarbonate and citric acid etc. one such or several, the lubricant includes magnesium stearate, hard Resin acid, talcum powder, silica, hydrogenated vegetable oil, polyethylene glycol, lauryl sodium sulfate, Compritol 888 ATO, stearic rich horse Sour sodium etc. is one such or several.
Corrigent of the present invention include Fruit powder, edible essence, high sweetener, acid etc. it is one such or Several, the Fruit powder includes orange powder, lemon powder, cherry powder, apple powder, strawberry powder, strawberry powder, kiwi fruit powder, tangerine powder, sand Spine fruit powder, green plum fruit powder, mango fruit powder, mulberry powder, hawthorn fruit powder, watermelon fruit powder, pineapple fruit powder, blueberry powder, honey peach Fruit powder, "Hami" melon fruit powder, grape fruit powder, vanilla fruit powder, pomegranate fruit powder, rose fruit powder etc. are one such or several.
Edible essence of the present invention include vanilla, orange flavor, milk flavour, flavoring apple essence, grape essence, Strawberry essence, flavoring pineapple essence, peach flavor, Hami melon essence, lemon extract, cherry essence, sweet corn flavor, banana incense Essence, grape essence, grape essence, flavoring rose essence, blackcurrant essence, green apple essence, mango essence, green mango essence, orange Essence, fragrant citrus essence, pyrus nivalis essence, strawberry essence, green plum essence, blueberry flavor, red bayberry essence, shaddock essence, flavoring pineapple essence, Guava essence, passion fruit essence, Chinese grooseberry essence, cherry essence, kiwi flavor, watermelon essence, pawpaw essence, "Hami" melon Essence, durian essence, lychee flavor, hawthorn essence, olive essence, flavoring mulberry essence etc. are one such or several.
High sweetener of the present invention includes Sucralose, Aspartame, mogroside, neotame, stevioside, institute The acid stated includes citric acid, citric acid, malic acid, lactic acid, tartaric acid and fumaric acid, and the edible pigment includes caramel Color, Gardenia Yellow, curcumin and chlorophyll, chilli orange, capsanthin, Grape Skin be red, carmine and its aluminum lake, sunset yellow and its Aluminum lake, brilliant blue and its aluminum lake, indigo and its aluminum lake, beet red, natural amaranth, gardenia blue, plant carbon black, iron oxide Black, iron oxide red, semen sojae atricolor be red, quinoline yellow, lycopene, Monascus color, yellow ferric oxide, cacao pigment, safflower yellow, monascus yellow pigment Deng one or more.
Stabilizer of the present invention includes vitamin E, dibutyl hydroxy toluene (BHT), butylated hydroxy anisole (BHA), vitamin C, the embedded object include beta-cyclodextrin, alpha-cyclodextrin, gamma-cyclodextrin, dextrin, starch, edible denaturation Starch, sucrose, maltodextrin, gum arabic etc. are one such or several.
The vitamin of health food screening function collaboration of the present invention carries out scientific composition, so that it is guaranteed that the function of product Effect, by supplementing optimal dose vitamin A, vitamin K, folic acid, vitamin B12, reach and increase bone density, pre- preventing bone rarefaction The effect of disease.
Vitamin A other than protection eyesight, the common effect such as prevent yctalopia and xerophthalmia, also with the close phase of bone health It closes.Vitamin A is proved to be present in osteoclast and osteoblast, and osteoblast is bon e formation, skeleton development and growth Important cells, it can be to generation collagenous fibres and matrix around it, and can promote matrix calcification.When vitamin A deficiency at Bone and it is osteoclastic between balance be broken, skeletal system metabolism is abnormal；Vitamin A deficiency also results on renal tubule Skin lesion wound, the protein-bonded biosynthesis of intracellular Ca2+ are reduced, and inhibit reabsorption of the renal tubule to calcium, and calcium content of bone reduces, prolongs Slow bone uptake.
Vitamin K is initially recognized with coagulation factor, is goed deep into recent years with research, finds vitamin K pair The importance that internal calcium is adjusted.Vitamin K participates in bone γ -2 carboxyglutamic acid protein or osteocalcin, matrix γ -2 carboxyglutamic acid Modification after protein transcription has positive effect to normal bone metabolism.Osteocalcin also cry bone γ-carboxyglutamic acid albumen or bone according to Rely property vitamin K albumen, reflects osteoblast maturation degree, activity, be the marker gene of osteoblast late differentiation, osteocalcin base It is weak with calcium-binding capacity because highly conserved, but there is high affinity with hydroxyapatite, inhibit the hydroxyapatite knot in bone Brilliant formation.Osteocalcin can also be combined into compound with osteopontin, and osteoclast can be concentrated on bone resorption portion by the latter Point, to promote bone resorption.Need vitamin K that could complete during osteocalcin carboxylation as coenzyme participation, with this as it can be seen that mending Filling vitamin K can promote bon e formation, reduces bone and decomposes, has assisting in preventing and treating effect to osteoporosis.
After homocysteine (Hcy) increases in blood, the probability that human body suffers from osteoporosis is also multiplied.Research card Real, either male or female subjects, after Hcy is more than normal value 25% in blood, the probability fractured is obvious Increase.The study found that folic acid or vitamin B12Shortage can lead to high Hcy mass formed by blood stasis, and deeper mechanisms are that methylation reaction is impaired: leaf Acid is through dihyrofolate reductase and vitamin B12Catalysis after form tetrahydrofolic acid, be combined into tetrahydrofolic acid with a variety of one carbon units Class coenzyme transmits the one carbon unit including methyl.During Hcy is methionine cyclic metabolism (be called one carbon unit circulation) The important intermediate of generation, catabolism need folic acid, vitamin B6、B12(with co-enzyme form) etc. participates in, therefore folic acid, dimension Raw element B12Shortage then causes Hcy metabolism to be obstructed, and Hcy accumulates in vivo, forms high Hcy mass formed by blood stasis.Therefore, Supplement of folic acid and vitamin B12High Hcy mass formed by blood stasis can be effectively relieved.In addition, vitamin B12It is important to maintaining central nervous system function normally also to have with folic acid Effect.
The selected related vitamin of the present invention, does not cause the potential disorder of bring of directly replenishing the calcium, equally reaches increase bone density Effect, preventing osteoporosis to the middle-aged and the old has significant health care or facilitation, the constituent significant in efficacy that is better than Independent or any united application effect.Compared with existing product, this patent product be a kind of better effect, it is less side effects Vitamin nutritional supplement or health food.Embodiments of the present invention are further described below with reference to embodiment.
Specific embodiment
Embodiment 1: the tablet of health food of the present invention prepares (1000 amounts)
Formula:
Preparation method: it takes PVP K30 to prepare composite adhesives with 50% ethanol solution, then vitamin A and vitamin K is added Enter in adhesive and stirs evenly, it is spare.Separately take vitamin B12, folic acid, Sucralose mix, be sieved with pregelatinized starch, then plus Enter milk flavour, carboxyrnethyl starch sodium, dextrin mixing, be added it is prepared containing vitamin A and vitamin K adhesive softwood, Magnesium stearate mixing, tabletting is added in the granulation of 24 meshes, 55 DEG C of dry 2h, 24 mesh sieves.Coating pre-mixing agent is configured to molten Liquid, plain piece coating, obtains the tablet of health food of the present invention.
Health food made from the present embodiment is taken, according to the evaluation of the Ministry of Public Health's " health food is examined and assessment technique specification " Method carries out animal function test and Toxicological evaluation test.
Animal contractile studies show: this health food can obviously increase bone density, reduce homocysteine level, Preventing osteoporosis to the middle-aged and the old has booster action.
Embodiment 2: the soft capsule of health food of the present invention prepares (1000 amounts)
Formula:
Preparation method: beeswax is added in soybean oil, and 50 DEG C of heating are dissolved beeswax, placed to room temperature, take vitamin A, Vitamin K, folic acid, vitamin B12It is added in soybean oil and suspension is made, it is spare.Separately take gelatin, purified water, burnt sugar coloring, to hydroxyl Yl benzoic acid ester is configured to glue, and soft capsule is made with pellet press pelleting in suspended matter obtained, is formed, and washes at ball and drying After reason, the soft capsule of health food of the present invention is obtained.
Embodiment 3: health food hard capsule of the present invention prepares (1000 amounts)
Formula:
Preparation method: folic acid is mixed with 20% microcrystalline cellulose, and sieving adds vitamin A dry powder, vitamin K, 5- Methyl tetrahydrofolate mixing, resulting raw mixture is mixed with the microcrystalline cellulose equal increments of surplus, adds cream Sugar, magnesium stearate mixing, are then filled using Autocapsulefillingmachine, are obtained after polished processing of the present invention The hard capsule of health food.
Embodiment 4: the granule preparation (1000 deal) of health food of the present invention
Formula:
Preparation method: sucrose crushing is sieved with 100 mesh sieve spare；PVP K30 is taken to be configured to bond with 50% ethanol solution Agent, then vitamin A and vitamin K are added to the adhesive and stirred evenly, it is spare.Separately take vitamin B12, folic acid mixed with sucrose, Sieving adds apple powder, flavoring apple essence, carboxyrnethyl starch sodium, maltodextrin mixing, be added it is prepared containing vitamin A and Vitamin K adhesive softwood, the granulation of 24 meshes, 55 DEG C of dry 2h, 24 mesh sieves obtain health food of the present invention Granule.
Embodiment 5: the chewable tablets of health food of the present invention prepares (1000 amounts)
Formula:
Preparation method: hydroxypropyl methylcellulose E5 is taken to prepare composite adhesives with 60% ethanol solution, then by vitamin A and Wei Sheng Plain K, which is added to the adhesive, to stir evenly, spare.Separately take vitamin B12, folic acid mix, be sieved with microcrystalline cellulose, add sweet tea Chrysanthemum glycosides, lemon extract, milk powder, xylitol mixing, be added it is prepared containing vitamin A and vitamin K adhesive softwood, 24 Magnesium stearate mixing is added in mesh granulation, 55 DEG C of dry 2h, 24 mesh sieves, and tabletting obtains health food of the present invention Chewable tablets.
Animal is carried out with a kind of health food suitable for the pre- anti-osteoporosis of the middle-aged and the old given by embodiment 1 below Experiment, further illustrating that the present invention has improves osteoporosis, alleviates calcium disorder and other effects.
1) material and method
1.1) sample: being sample according to the capsule that embodiment 1 is produced.
1.2) dosage group selection and tested material give mode: low calcium feed formula (gram): casein 10.0, soybean powder 15.0, wheat flour 54.0, peanut oil 4.0, cellulose 2.0, AIN-76 salt-mixture 2.6, AIN-76 mixed vitamin 1.0, chlorination Choline 0.2, DL- METHIONINE 0.2, starch 11.0, CaCO3, which is added, makes feed calcium content reach 150mg/100g, raises as low calcium Material.
According to human oral's recommended amounts, sample of the invention is that basic, normal, high dosage is respectively 0.25g/kg.bw, 0.50g/ Kg.bw, 1.50g/kg.bw (are respectively equivalent to 5 times, 10 times, 30 times that human body recommends dosage), when calcium carbonate reference substance is prepared, The calcium carbonate (being equivalent to high dose of the invention) of basic, normal, high dosage.When preparing sample, basic, normal, high dosage takes respectively 2.50g, 5.00g, 15.00g add deionized water to 100ml, and calcium carbonate control group takes 5.97g calcium carbonate to add deionized water extremely 100ml, low calcium control group give isometric deionized water, give animal subject stomach-filling respectively, and daily stomach-filling is primary, stomach-filling body Product is 11.0ml/100g.bw.
1.3) experimental situation condition: experimental situation is barrier environment.22 DEG C~24 DEG C of environment temperature, humidity 52~58%. 1.4) key instrument: SD-1000C bone mineral measuring instrument.
1.5) experimental method:
Growth and development index: weighing in weekly and height.
Femur-bone densitometry: at the end of experiment, sacrificed by decapitation rat removes right femur, permanent through being baked in 105 ovens Weight, after being cooled to room temperature, measures the length of femur and the bone density of midpoint and distal end.
Calcium content of bone measurement: EDTA titration measuring is used after weighing the total weight of femur.
Functional component, physical and chemical index, sanitary index: according to enterprise-quality standard test.
2) experimental result
2.1) data conversion and statistical analysis Data Processing in Experiment: are carried out with Spss11.0 software.
2.2) interpretation of result: the calcium content of bone or bone density for giving tested material group are significantly higher than low calcium control group, and with phase It is not significantly different compared with dosage calcium carbonate control group, the absorptivity of calcium is not less than calcium carbonate control group, can determine that tested material Have the function of increasing bone density；Its functional component index, physical and chemical index, Hygienic Index meet company standard Q/ The regulation of RCH007-2009D.
Influence of 1 sample of table to rat body weight
As shown in Table 1, the starting of experimental group rat and mid-term weight are compared with low calcium control group without significant difference (P > 0.05)；Calcium carbonate control group and high dose group rat latter stage weight and weight gain there were significant differences compared with low calcium control group (P < 0.01), the initial weight of high dose group experimental group rat.Mid-term weight, latter stage weight and its have a net increase of it is value added with calcium carbonate control group compared with do not have There is marked difference (P > 0.05).
Influence of 2 sample of table to rat femur length and bone density
As can be seen from Table 2, the femur length of high dose group rat, femur center bone density, femur distal end bone density Compared with corresponding calcium carbonate control group, it is not significantly different (P > 0.05)；Calcium carbonate control group, high calcium dosage group femur are long Degree is noticeably greater than low calcium control group (P < 0.01)；Calcium carbonate control group, middle dose group, high dose group rat femur center bone are close Degree is noticeably greater than low calcium control group (P < 0.01).Calcium carbonate control group and high dose group rat femur distal end bone density are significant Greater than low calcium control group (P < 0.01).
The femur weight of 3 sample high dose group rat of table, the influence of femur calcium content
As can be seen from Table 4, the femur weight of sample high dose group rat, the influence of femur calcium content.High dose experiment Femur weight, femur calcium content and the calcium total amount of group rat are not significantly different (P > compared with corresponding calcium carbonate control group 0.05)；Calcium carbonate control group, high calcium dosage group femur weight are noticeably greater than low calcium control group (P < 0.01)；Calcium carbonate control Group, middle dose group, high dose group rat femur total calcium content and calcium content are noticeably greater than low calcium control group (P < 0.01).
Show using capsule prepared by technique given by the present invention there is enhancing to increase bone density through animal test results Function.

Claims (6)

1. a kind of health food, by vitamin A, vitamin K, vitamin B12, folic acid and health food acceptable auxiliary material composition.
2. health food according to claim 1, it is characterised in that: the vitamin A content is 250~800 μ g, preferably 600~800 μ g；The vitamin K content is 10~100 μ g, preferably 35~100 μ g；The vitamin B12Content is 5~20 μ G, preferably 5~10 μ g；The folate content is 200~800 μ g, preferably 400~600 μ g.
3. health food according to claims 1 to 2, it is characterised in that: the folic acid includes folic acid, 5- methyl tetrahydro Folic acid, formyl tetrahydrofolic acid, folinic acid, Calcium Levofolinate etc. include artificial synthesized and plant extract source various shapes Formula folic acid.
4. health food according to claims 1 to 2, it is characterised in that: the vitamin K includes plant origin K1, microbe-derived K2 and artificial synthesized K3 and K4, the K1 in preferred plant source and microbe-derived K2.
5. health food according to claim 1, it is characterised in that: the health food or nutritional supplement can be made into The peroral dosage forms such as conventional tablet, chewable tablet, soft capsule, hard capsule, pulvis and granule.
6. the guarantor that the described in any item health foods of Claims 1 to 5 can be used for the pre- anti-osteoporosis of the middle-aged and the old in preparation Purposes in health food or nutritional supplement.
CN201810305035.4A 2018-04-08 2018-04-08 A kind of health food for the pre- preventing bone rarefaction of the middle-aged and the old Pending CN110338423A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060216361A1 (en) * 2005-03-10 2006-09-28 Edwards John B Compositions and methods for the treatment of osteoporosis and inflammatory joint disease
WO2008090201A1 (en) * 2007-01-25 2008-07-31 Phrontier S.A.R.L. Use of folic acid, vitamin b6, and vitamin b12
CN102318835A (en) * 2011-08-31 2012-01-18 石家庄中硕药业集团有限公司 Composition for reducing bone loss and preparation method thereof
CN106798337A (en) * 2017-01-18 2017-06-06 深圳泰乐德营养与健康有限公司 A kind of nutritious supplementary pharmaceutical suitable for the elderly
CN107028191A (en) * 2017-05-24 2017-08-11 深圳泰乐德营养与健康有限公司 A kind of vitamin combination of the accurate nutrition of suitable mid-aged population
CN107232611A (en) * 2017-05-22 2017-10-10 深圳泰乐德营养与健康有限公司 A kind of nutrient composition being made up of vitamin D, K and folic acid

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060216361A1 (en) * 2005-03-10 2006-09-28 Edwards John B Compositions and methods for the treatment of osteoporosis and inflammatory joint disease
WO2008090201A1 (en) * 2007-01-25 2008-07-31 Phrontier S.A.R.L. Use of folic acid, vitamin b6, and vitamin b12
CN102318835A (en) * 2011-08-31 2012-01-18 石家庄中硕药业集团有限公司 Composition for reducing bone loss and preparation method thereof
CN106798337A (en) * 2017-01-18 2017-06-06 深圳泰乐德营养与健康有限公司 A kind of nutritious supplementary pharmaceutical suitable for the elderly
CN107232611A (en) * 2017-05-22 2017-10-10 深圳泰乐德营养与健康有限公司 A kind of nutrient composition being made up of vitamin D, K and folic acid
CN107028191A (en) * 2017-05-24 2017-08-11 深圳泰乐德营养与健康有限公司 A kind of vitamin combination of the accurate nutrition of suitable mid-aged population

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