CN110338424A - A kind of health food suitable for the middle-aged and the old - Google Patents
A kind of health food suitable for the middle-aged and the old Download PDFInfo
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- CN110338424A CN110338424A CN201810305048.1A CN201810305048A CN110338424A CN 110338424 A CN110338424 A CN 110338424A CN 201810305048 A CN201810305048 A CN 201810305048A CN 110338424 A CN110338424 A CN 110338424A
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- Prior art keywords
- vitamin
- health food
- calcium
- content
- folic acid
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- 210000003491 skin Anatomy 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
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- 235000003702 sterols Nutrition 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
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- 239000011593 sulfur Substances 0.000 description 1
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- 230000001502 supplementing effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
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- 238000004448 titration Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
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- 235000013311 vegetables Nutrition 0.000 description 1
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- 239000011718 vitamin C Substances 0.000 description 1
- 102000009310 vitamin D receptors Human genes 0.000 description 1
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- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a kind of health foods or nutritional supplement being made of vitamin A, vitamin D, vitamin K, folic acid and appropriate auxiliary material, wherein vitamin A content is 250~800 μ g, vitamin D content is 5~15 μ g, vitamin K content is 10~100 μ g, and folate content is 200~800 μ g.The invention has the advantages that selected function related vitamin, prescription is scientific, reasonable, for the pre- anti-osteoporosis of the middle-aged and the old, has effects that synergistic effect between each composition, and embody accurate nutritional characteristic.
Description
Technical field
The present invention relates to a kind of health foods, more precisely, prevent sclerotin the present invention relates to a kind of couple of middle-aged and the old and dredge
Loose disease has the health food for assisting protective effect.
Technical background
The osteoporosis problem of the middle-aged and the old is quite serious.Osteoporosis (osteoporosis, OP) is one kind with bone
Amount is low, bone micro-structure destroys, bone brittleness increases, the systemic osteopathy that fracture is characterized easily occurs.The middle-aged and the old is that sclerotin is dredged
The group of people at high risk of pine, according to statistics, the patient of global osteoporosis about 200,000,000, and the age is more than 50% women in 50 years old crowd
It will appear osteoporosis with 20% male.Chinese society aging progress faster, the ratio of the elderly is higher and higher, osteoporosis
The disease incidence of disease also will be in rising trend.Osteoporosis can lead to the problems such as pain, fracture, textured bone, threaten the elderly's
Health and Living quality, most serious consequence of the Hip Fracture as osteoporosis, it might even be possible to cause death.
Homocysteine (homocysteine, Hcy) is a kind of sulfur-containing amino acid, is the centre of Methionine metabolism process
Product.The study found that high Hcy mass formed by blood stasis be not only cardiovascular disease risk factor (pathogenic mechanism include damage blood vessel endothelium, promote
Into vascular smooth muscle cell proliferation and artery sclerosis etc.), while being also a risk factor of osteoporotic fracture.High Hcy
Mass formed by blood stasis can interfere with the connection of collagen fabric and tissue, to promote osteoporosis, according to 19% senile bone of reckoning
It rolls over related with high Hcy level.Human body blood Hcy level, which depends on factors, the folic acid insufficiency of intakes such as heredity, diet, can make blood Hcy
Increase, investigation display, the folic acid intake of many national crowds is insufficient in the world, this Chinese problem due to genetic background more
Aobvious prominent (aftermentioned).
Currently, the health food for " increasing bone density " in the market is the health food of calcic mostly, it is by directly supplementing
Absorption that is calcareous and promoting calcium by vitamin D increases bone density purpose to reach.But US Experts discovery is simple to mend
Fill calcium and vitamin D be for the prevention and treatment of osteoporosis it is far from being enough, this is global traditional understanding mistaken ideas.Clinical practice
It has been confirmed that: a large amount of supplement calcium preparations can not improve bone density, prevention or treatment osteoporosis.More frighteningly, a large amount of to mend
It is excessively high that calcium will cause blood calcium in human body, causes a series of cardiovascular and cerebrovascular diseases, such as atherosclerosis, apoplexy, a large amount of blood
Calcium ion with blood migration, may deposit in internal organs because that can not combine with synosteosis albumen, will cause the interior accumulation of yin cold in viscera
Stone forms spur etc., causes bigger physiological load and physical pain.Therefore, invent one kind can supplement calcium, increase bone it is close
Degree, but the health care product that can solve bone doped calcium problem is particularly important.
Summary of the invention
The purpose of the present invention is to provide a kind of couple of middle-aged and the old to prevent the guarantor that osteoporosis has auxiliary protection function
Health food.
To achieve the goals above, the invention adopts the following technical scheme:
A kind of couple of middle-aged and the old prevents the health food that osteoporosis has auxiliary protection function, by following component group
At:
(1) vitamin A
(2) vitamin D
(3) vitamin K
(4) folic acid
(5) auxiliary material.
In above-mentioned health food, vitamin A content is 250~800 μ g, and vitamin D content is 5~15 μ g, vitamin K
Content is 10~100 μ g, and folate content is 200~800 μ g.
Preferably, health food of the present invention, vitamin A content be 600~800 μ g, vitamin D content be 8~
15 μ g, vitamin K content are 35~100 μ g, and folate content is 400~800 μ g.
In the present invention, the folic acid includes folic acid, 5-methyltetrahydrofolate, formyl tetrahydrofolic acid, folinic acid, Zuo Yaye
Sour calcium etc. includes artificial synthesized and plant extract source various forms folic acid.
In the present invention, the vitamin K includes K1, the microbe-derived K2 of plant origin and artificial synthesized
K3 and K4, the K1 in preferred plant source and microbe-derived K2.
Health food of the present invention can be made into conventional tablet, chewable tablet, soft capsule, hard capsule, pulvis and
The peroral dosage forms such as granule.
In the present invention, the auxiliary material be selected from filler (dispersing agent), suspending agent, wetting agent, adhesive, disintegrating agent,
The combination of one or more of lubricant, corrigent, stabilizer, embedded object, coating pre-mixing agent, edible pigment.
Wherein, filler (dispersing agent) of the present invention includes starch, soluble starch, dextrin, maltodextrin, Ma Ling
Sweet potato starch, cornstarch, wheaten starch, D-mannital, calcium monohydrogen phosphate, calcium phosphate dibasic anhydrous, maltose, xylitol, sorb
Sugar alcohol, microcrystalline cellulose, isomaltoketose, milk powder, low-substituted hydroxypropyl cellulose, sucrose, glucose, lactose, pregelatinized starch,
The one or more of edible vegetable oil, polyethylene glycol etc..
Suspending agent of the present invention include beeswax, insect wax, lecithin, glycerin monostearate, ethyl cellulose etc. its
One or more of, the wetting agent includes purified water and ethyl alcohol, the adhesive include hydroxypropyl methyl cellulose,
Povidone, hydroxypropylcellulose, carmethose, starch, methylcellulose, ethyl cellulose, gelatin, polyethylene glycol, pre- glue
It is one of or several to change starch, sucrose, glucose etc..
Disintegrating agent of the present invention includes starch, carboxyrnethyl starch sodium, crospovidone, cross-linked carboxymethyl cellulose sodium, low
Replace hydroxypropylcellulose, sodium bicarbonate and citric acid etc. one such or several, the lubricant includes magnesium stearate, hard
Resin acid, talcum powder, silica, hydrogenated vegetable oil, polyethylene glycol, lauryl sodium sulfate, Compritol 888 ATO, stearic rich horse
Sour sodium etc. is one such or several.
Corrigent of the present invention include Fruit powder, edible essence, high sweetener, acid etc. it is one such or
Several, the Fruit powder includes orange powder, lemon powder, cherry powder, apple powder, strawberry powder, strawberry powder, kiwi fruit powder, tangerine powder, sand
Spine fruit powder, green plum fruit powder, mango fruit powder, mulberry powder, hawthorn fruit powder, watermelon fruit powder, pineapple fruit powder, blueberry powder, honey peach
Fruit powder, "Hami" melon fruit powder, grape fruit powder, vanilla fruit powder, pomegranate fruit powder, rose fruit powder etc. are one such or several.
Edible essence of the present invention include vanilla, orange flavor, milk flavour, flavoring apple essence, grape essence,
Strawberry essence, flavoring pineapple essence, peach flavor, Hami melon essence, lemon extract, cherry essence, sweet corn flavor, banana incense
Essence, grape essence, grape essence, flavoring rose essence, blackcurrant essence, green apple essence, mango essence, green mango essence, orange
Essence, fragrant citrus essence, pyrus nivalis essence, strawberry essence, green plum essence, blueberry flavor, red bayberry essence, shaddock essence, flavoring pineapple essence,
Guava essence, passion fruit essence, Chinese grooseberry essence, cherry essence, kiwi flavor, watermelon essence, pawpaw essence, "Hami" melon
Essence, durian essence, lychee flavor, hawthorn essence, olive essence, flavoring mulberry essence etc. are one such or several.
High sweetener of the present invention includes Sucralose, Aspartame, mogroside, neotame, stevioside, institute
The acid stated includes citric acid, citric acid, malic acid, lactic acid, tartaric acid and fumaric acid, and the edible pigment includes caramel
Color, Gardenia Yellow, curcumin and chlorophyll, chilli orange, capsanthin, Grape Skin be red, carmine and its aluminum lake, sunset yellow and its
Aluminum lake, brilliant blue and its aluminum lake, indigo and its aluminum lake, beet red, natural amaranth, gardenia blue, plant carbon black, iron oxide
Black, iron oxide red, semen sojae atricolor be red, quinoline yellow, lycopene, Monascus color, yellow ferric oxide, cacao pigment, safflower yellow, monascus yellow pigment
Deng one or more.
Stabilizer of the present invention includes vitamin E, dibutyl hydroxy toluene (BHT), butylated hydroxy anisole
(BHA), vitamin C, the embedded object include beta-cyclodextrin, alpha-cyclodextrin, gamma-cyclodextrin, dextrin, starch, edible denaturation
Starch, sucrose, maltodextrin, gum arabic etc. are one such or several.
The vitamin of health food screening function collaboration of the present invention carries out scientific composition, so that it is guaranteed that the function of product
Effect can increase bone density, to reach prevention by supplement optimal dose vitamin A, vitamin D, vitamin K and folic acid
The effect of osteoporosis.
Vitamin A is still closely related with bone health in addition to common effects such as common protection eyesights.Studies have shown that
Vitamin A is present in osteoblast and osteoclast, there is that osteoblast activity is activated to inhibit osteoclast activity.
Osteoblast is bon e formation, the important cells of skeleton development and growth, it can to generating collagenous fibres and matrix around it, and
It can promote matrix calcification.When vitamin A deficiency, bone tissue will be denaturalized, cause skeletonization and it is osteoclastic between imbalance；Dimension life
Plain A shortage also results in tubular epithelial injury, and the protein-bonded biosynthesis of intracellular Ca2+ is reduced, and inhibits renal tubule to calcium
Reabsorption, calcium content of bone reduce, delay bone uptake, keep bone moulding bad, lead to the generation of osteoporosis.
Vitamin D is a kind of liposoluble vitamin, is sterol analog derivative, there are five types of compounds, closeer with healthy relationship
What is cut is calciferol and D3, is present in the natural food of part, can be converted by the ultraviolet light irradiation intracorporal cholesterol of descendant
Vitamin D.Vitamin D receptor is present in body most tissues, many common diseases include some kinds of tumor, diabetes,
Senile dementia, cardiovascular disease and osteoporosis are all related with vitamin D deficiency.Vitamin D deficiency has become public health
Problem.Vitamin D is to maintain one of essential substance of bone health, promotes Calcium and phosphorous absorption, calcified bone matrix, keeps sclerotin hard
Firmly, osteopontin and the alkaline phosphatase enzymatic synthesis in osteoblast are also stimulated, TNF-a Induced Apoptosis in Osteoblasts, advantageous bon e formation are inhibited.Dimension
Raw element D shortage causes or aggravates adult bone amount reduction and osteoporosis, or even causes osteomalacia and myasthenia, increases fracture wind
Danger.
Vitamin K is initially recognized with coagulation factor by people, in recent years, with going deep into for research, finds vitamin K
The importance that internal calcium is adjusted.Vitamin K participates in bone γ -2 carboxyglutamic acid protein or osteocalcin, matrix γ -2 carboxyl paddy ammonia
Acid albumin transcription after modification, play the role of to normal bone metabolism it is positive, be blood calcium conversion skeletonization calcium key factor.Bone
Calcium element is reflection osteoblast maturation degree, activity, is the marker gene of osteoblast late differentiation.Osteocalcin can be with bone bridge egg
White to be combined into compound, osteoclast can be concentrated on bone resorption part by the latter, to promote bone resorption.In osteocalcin carboxylation
Needing vitamin K in the process could complete as coenzyme participation.Calcium can be made by intestinal absorption with vitamin D combination, smoothly
Bone calcium is converted by blood calcium, is truly realized and is ideally deposited on calcium in bone, raising bone density rapidly and efficiently.It can with this
See, replenishing vitamins K can promote bon e formation, reduce bone catabolism, plays an important role to blood calcium conversion skeletonization calcium, solves bone calcium
Problem is deposited, is helped out to the prevention and treatment of osteoporosis.
Folic acid belongs to B family vitamin, the necessary material for growing and breeding for body cell.Homocysteine (Hcy) generation
It thanks and needs the B family vitamins such as folic acid to participate in and be provided methyl.Hcy metabolism is obstructed when folic acid deficiency, and Hcy accumulates in vivo,
When Hcy value is excessively high, the increased risk of fracture.On the other hand, methylenetetrahydrofolate reductase (MTHFR) gene pleiomorphism can
Population of China can be caused to the relative deficiency of folic acid Utilization ability: MTHFR is that 5,10- methylene tetrahydrofolate is reduced to 5- methyl
The key enzyme of tetrahydrofolic acid, is remarkably decreased enzymatic activity if gene mutation, and influencing exogenous folic acid activation is 5- methyl tetrahydro
Folic acid, and then influence one carbon unit transmitting.There are three types of genotype, i.e. homozygous wildtype (CC), heterozygous (CT) by MTHFR C677T
With homozygous mutant (TT), TT type enzymatic activity only has CC type 30%.Population of China TT genotype frequency average 23.2%, it is significantly high
In American-European countries, the habit of high-temperature cooking vegetables, folic acid deficiency rate (65%) are apparently higher than American-European countries in addition.
In short, appropriate specific aim replenishing vitamins A, vitamin D, vitamin K and folic acid, not only promote Calcium and phosphorous absorption, promote
Into blood calcium to the conversion of bone calcium, promote calcified bone matrix, keep sclerotin hard, can also plasma Hcy level be made to reduce, it is close to increase bone
Degree, four prevention and treatment for playing centering senile osteoporosis disease jointly play auxiliary protection function.
Compared with existing product, product of the present invention is a kind of better effect, more scientific vitamin functional health
Food, the independent or any united application effect significant in efficacy for being better than constituent.Below with reference to embodiment to of the invention
Embodiment is further described.
Specific embodiment
Embodiment 1: the tablet of health food of the present invention prepares (1000 amounts)
Formula:
Preparation method: take PVP K30 with 50% ethanol solution prepare composite adhesives, then by vitamin A, vitamin D and
Vitamin K, which is added to the adhesive, to stir evenly, spare.Separately folic acid, Sucralose is taken to mix, be sieved with pregelatinized starch, then plus
Enter milk flavour, carboxyrnethyl starch sodium, dextrin mixing, addition is prepared to contain vitamin A, vitamin D and vitamin K adhesive
Magnesium stearate mixing, tabletting is added in softwood processed, the granulation of 24 meshes, 55 DEG C of dry 2h, 24 mesh sieves.Coating pre-mixing agent is matched
Solution is made, plain piece coating obtains the tablet of health food of the present invention.
Embodiment 2: the soft capsule of health food of the present invention prepares (1000 amounts)
Formula:
Preparation method: beeswax is added in soybean oil, and 50 DEG C of heating are dissolved beeswax, placed to room temperature, take vitamin A,
Vitamin D, vitamin K, folic acid, which are added in soybean oil, is made suspension, spare.Separately take gelatin, purified water, burnt sugar coloring, to hydroxyl
Benzoic ether is configured to glue, and soft capsule is made with pellet press pelleting in suspended matter obtained, is formed, washes ball and drying process
Afterwards, the soft capsule of health food of the present invention is obtained.
Embodiment 3: health food hard capsule of the present invention prepares (1000 amounts)
Formula:
Preparation method: folic acid is mixed with 20% microcrystalline cellulose, and sieving adds vitamin A dry powder, vitamin D, dimension
Raw element K, 5-methyltetrahydrofolate mixing, resulting raw mixture is mixed with the microcrystalline cellulose equal increments of surplus,
Lactose, magnesium stearate mixing are added, is then filled using Autocapsulefillingmachine, this is obtained after polished processing
Invent the hard capsule of the health food.
Embodiment 4: the granule preparation (1000 deal) of health food of the present invention
Formula:
Preparation method: sucrose crushing is sieved with 100 mesh sieve spare；PVP K30 is taken to be configured to bond with 50% ethanol solution
Agent, then vitamin A, vitamin D and vitamin K are added to the adhesive and stirred evenly, it is spare.Separately folic acid is taken to mix with sucrose,
Sieving adds apple powder, flavoring apple essence, carboxyrnethyl starch sodium, maltodextrin mixing, is added prepared containing vitamin A, dimension
Raw element D and vitamin K adhesive softwood, the granulation of 24 meshes, 55 DEG C of dry 2h, 24 mesh sieves obtain of the present invention
The granule of health food.
Embodiment 5: the chewable tablets of health food of the present invention prepares (1000 amounts)
Formula:
Preparation method: it takes hydroxypropyl methylcellulose E5 to prepare composite adhesives with 60% ethanol solution, then vitamin A, dimension is given birth to
Plain D and vitamin K, which are added to the adhesive, to stir evenly, spare.Separately folic acid is taken to mix, be sieved with microcrystalline cellulose, adds sweet tea
Chrysanthemum glycosides, lemon extract, milk powder, xylitol mixing, addition is prepared to contain vitamin A, vitamin D and vitamin K adhesive
Magnesium stearate mixing is added in softwood processed, the granulation of 24 meshes, 55 DEG C of dry 2h, 24 mesh sieves, and tabletting obtains of the present invention
The chewable tablets of health food.
Zoopery is carried out with a kind of health food suitable for the middle-aged and the old given by embodiment 1 below, furtherly
The bright present invention, which has, increases bone density, improves the effect of osteoporosis.
(1) material and method
Sample: being sample according to the tablet that embodiment 1 is produced.
Dosage group selection and tested material give mode: low calcium feed formula (gram): casein 10.0, soybean powder 15.0 are small
Flour 54.0, peanut oil 4.0, cellulose 2.0, AIN-76 salt-mixture 2.6, AIN-76 mixed vitamin 1.0, choline chloride 0.2,
DL- METHIONINE 0.2, starch 11.0, CaCO3, which is added, makes feed calcium content reach 150mg/100g, as low calcium feed.
According to human oral's recommended amounts, sample of the invention is that basic, normal, high dosage is respectively 0.25g/kg.bw, 0.50g/
Kg.bw, 1.50g/kg.bw (are respectively equivalent to 5 times, 10 times, 30 times that human body recommends dosage), when calcium carbonate reference substance is prepared,
The calcium carbonate (being equivalent to high dose of the invention) of basic, normal, high dosage.When preparing sample, basic, normal, high dosage takes respectively
2.50g, 5.00g, 15.00g add deionized water to 100ml, and calcium carbonate control group takes 5.97g calcium carbonate to add deionized water extremely
100ml, low calcium control group give isometric deionized water, give animal subject stomach-filling respectively, and daily stomach-filling is primary, stomach-filling body
Product is 11.0ml/100g.bw.
Key instrument: SD-1000C bone mineral measuring instrument.
Experimental method:
Growth and development index: it weighs in weekly.
Femur-bone densitometry: at the end of experiment, sacrificed by decapitation rat removes right femur, permanent through being baked in 105 ovens
Weight, after being cooled to room temperature, measures the length of femur and the bone density of midpoint and distal end.
Calcium content of bone measurement: EDTA titration measuring is used after weighing the total weight of femur.
(2) experimental result
Data Processing in Experiment: data conversion and statistical analysis are carried out with Spss11.0 software.
Interpretation of result: the calcium content of bone or bone density for giving tested material group are significantly higher than low calcium control group, and with identical dose
For amount calcium carbonate control group compared to being not significantly different, the absorptivity of calcium is not less than calcium carbonate control group, can determine that tested material has
Increase the effect of bone density；Its functional component index, physical and chemical index, Hygienic Index meet company standard Q/RCH007-
The regulation of 2009D.
Influence of 1 sample of table to rat body weight
As shown in Table 1, the starting of experimental group rat and mid-term weight are compared with low calcium control group without significant difference (P >
0.05)；Calcium carbonate control group and high dose group rat latter stage weight and weight gain there were significant differences compared with low calcium control group (P <
0.01), the initial weight of high dose group experimental group rat.Mid-term weight, latter stage weight and its have a net increase of it is value added with calcium carbonate control group compared with do not have
There is marked difference (P > 0.05).
Influence of 2 sample of table to rat femur length and bone density
As can be seen from Table 2, the femur length of high dose group rat, femur center bone density, femur distal end bone density
Compared with corresponding calcium carbonate control group, it is not significantly different (P > 0.05)；Calcium carbonate control group, high calcium dosage group femur are long
Degree is noticeably greater than low calcium control group (P < 0.01)；Calcium carbonate control group, middle dose group, high dose group rat femur center bone are close
Degree is noticeably greater than low calcium control group (P < 0.01).Calcium carbonate control group and high dose group rat femur distal end bone density are significant
Greater than low calcium control group (P < 0.01).
The femur weight of 3 sample high dose group rat of table, the influence of femur calcium content
As can be seen from Table 3, the femur weight of sample high dose group rat, the influence of femur calcium content.High dose experiment
Femur weight, femur calcium content and the calcium total amount of group rat are not significantly different (P > compared with corresponding calcium carbonate control group
0.05)；Calcium carbonate control group, high calcium dosage group femur weight are noticeably greater than low calcium control group (P < 0.01)；Calcium carbonate control
Group, middle dose group, high dose group rat femur total calcium content and calcium content are noticeably greater than low calcium control group (P < 0.01).
Show using tablet prepared by technique given by the present invention there is enhancing to increase bone density through animal test results
Function.
Claims (6)
1. a kind of health food is made of vitamin A, vitamin D, vitamin K, folic acid and the acceptable auxiliary material of health food.
2. health food according to claim 1, it is characterised in that: the vitamin A content is 250~800 μ g, preferably
600~800 μ g；The vitamin D content is 5~15 μ g, preferably 8~15 μ g；The vitamin K content is 10~100 μ g, excellent
35~100 μ g are selected, the folate content is 200~800 μ g, preferably 400~800 μ g.
3. health food according to claims 1 to 2, it is characterised in that: the folic acid includes folic acid, 5- methyl tetrahydro
Folic acid, formyl tetrahydrofolic acid, folinic acid, Calcium Levofolinate etc. include artificial synthesized and plant extract source various shapes
Formula folic acid.
4. health food according to claims 1 to 2, it is characterised in that: the vitamin K includes plant origin
K1, microbe-derived K2 and artificial synthesized K3 and K4, the K1 in preferred plant source and microbe-derived K2.
5. health food according to claim 1, it is characterised in that: the health food can be made into conventional tablet, nozzle
The peroral dosage forms such as chewable tablet, soft capsule, hard capsule, pulvis and granule.
6. the health care that the described in any item health foods of Claims 1 to 5 are used for the pre- anti-osteoporosis of the middle-aged and the old in preparation
Purposes in product or accurate nutritional supplement.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115316669A (en) * | 2021-05-11 | 2022-11-11 | 深圳芙莱特营养与健康有限公司 | Nutrient composition |
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