CN106901378A - A kind of health food suitable for women - Google Patents
A kind of health food suitable for women Download PDFInfo
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- CN106901378A CN106901378A CN201710140768.2A CN201710140768A CN106901378A CN 106901378 A CN106901378 A CN 106901378A CN 201710140768 A CN201710140768 A CN 201710140768A CN 106901378 A CN106901378 A CN 106901378A
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- Prior art keywords
- vitamin
- health food
- women
- folic acid
- health
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- 235000019412 neotame Nutrition 0.000 description 1
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- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 235000012658 paprika extract Nutrition 0.000 description 1
- 239000001688 paprika extract Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 235000012752 quinoline yellow Nutrition 0.000 description 1
- 239000004172 quinoline yellow Substances 0.000 description 1
- 229940051201 quinoline yellow Drugs 0.000 description 1
- IZMJMCDDWKSTTK-UHFFFAOYSA-N quinoline yellow Chemical compound C1=CC=CC2=NC(C3C(C4=CC=CC=C4C3=O)=O)=CC=C21 IZMJMCDDWKSTTK-UHFFFAOYSA-N 0.000 description 1
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- 239000004576 sand Substances 0.000 description 1
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- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229960005137 succinic acid Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
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- 230000002792 vascular Effects 0.000 description 1
- 230000009441 vascular protection Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019195 vitamin supplement Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention provides one kind by vitamin E, folic acid, vitamin B12And the health food or nutritious supplementary pharmaceutical of appropriate auxiliary material composition, wherein content of vitamin E is that 10~500mg, folate content are 0.2~2.0mg, vitamin B12Content is 5~100 μ g.Health food of the invention has beautifying and anti-aging effect, has auxiliary protection function to Women of childbearing age healthy reproduction and to middle and aged women cardiovascular health；The method have the advantages that:Selected function related vitamin, for specific crowd, acts synergistically between each composition with effect, embodies accurate nutritional characteristic.
Description
Technical field
The present invention relates to a kind of health food, more precisely, the present invention relates to a kind of beautifying and anti-aging, to Women of childbearing age
There is the health food of cardiovascular auxiliary protection function with reproductive health care, to middle aged and aged women.
Background technology
In modern society, mobile phone, micro-wave oven, the radiation of refrigerator and the pollution of living environment all accelerate human senescence.And with
Age increase, human body target tissue changes to the reactivity of some hormones or active material or substantially reduces, and divides in body
Secrete systemic-function to go down, so as to accelerate aging course.On the other hand, human body oxidation resistance with age also decline,
The generation of women oxygen radical after 25 years old gradually exceedes body ability to bear, the peroxylradicals produced in substance metabolism process
Body injury, such as unrighted acid can be caused to be oxidized to superoxides, form lipofuscin.Oxygen radical destruction cell membrane is complete
Property, make protein and enzyme denaturation, when radical damage accumulation is beyond body repair ability, then cell differentiation state change declines
It is old to accelerate.
Epidemiology survey finds that estrogen deficiency is the important paathogenic factor that cardiovascular disease in women occurs, post menopausal
There is the risk of angiocardiopathy apparently higher than Pre-menopausal Women in women, and this risk increases in just with the postclimacteric age
It is related.Postmenopausal women, especially more than the 60 years old cardiovascular disease in women incidence of disease rise and accelerate, and reach and male's incidence of disease
Suitable level.Investigation also shows that premenopausal, the ill ratio of men and women's coronary heart disease is 4 to women:1；Post menopausal, this ratio
Narrow down to 3:2~2:1, and reach 1 to this ratio at more than 60 years old:1, even more high.To find out its cause, mainly women post menopausal
Endogenous estrogen secretion is reduced, and the protection to cardiovascular system weakens.
B B-complex product is numerous in the market, mostly nutritious supplementary pharmaceutical, and various people can all take, but due into
Point many, every kind of constituent content is relatively low, and lack of targeted, actual health-care effect is in the lap of future.Therefore, it is contemplated that exploitation is a kind of
Women beautifying and anti-aging based on vitamin E, there is reproductive health care to Women of childbearing age and there are painstaking effort to middle aged and aged women
The health food of pipe auxiliary protection function, is the improvement to existing multivitamin product, is also complied with current to specific crowd reality
Apply the development trend of accurate nutrition.
The content of the invention
It is an object of the invention to provide a kind of beautifying and anti-aging, to Women of childbearing age reproductive health care, to the middle aged and aged women heart
Vascular system has the health food of auxiliary protection function.
To achieve these goals, the present invention uses following technical scheme：
A kind of B B-complex health food, consists of the following composition：
(1) vitamin E；(2) vitamin B12；(3) folic acid；(4) auxiliary material.
In above-mentioned health food, content of vitamin E is 10~500mg, vitamin B12Content is 5~100 μ g, and folic acid contains
It is 0.2~2.0mg to measure, preferably.
Preferably, health food of the present invention, content of vitamin E is 15~200mg, vitamin B12Content be 5~
20 μ g, folate content is 0.4~1.0mg.
Vitamin E of the present invention includes natural VE (D- alpha-tocopherols, D- α-D-α-tocopherol acetate, D- α-butanedioic acid
Tocopherol), dl- α-D-α-tocopherol acetate, dl- alpha-tocopherols, the form such as VE succinic acid calcium, wherein alpha-tocopherol is nature
The most abundant active highest vitamin E form of most Extensive quantity is distributed in boundary.
Leaf acid of the present invention includes folic acid, 5-methyltetrahydrofolate, calcium leucovorin, L- methyl leaves
The active metabolite of acid, folate, folic acid or folate and the material of folic acid can be in vivo discharged/generate, i.e., including artificial conjunction
Into and plant extract source various folic acid forms.5-methyltetrahydrofolate is particularly suited for TT genotype crowds, increases it
To folic acid utilization ratio.
Vitamin B of the present invention12Including cobalamin, Mecobalamin element, 5 '-deoxyadenosyl cobalamin, hydroxocobalamine, cyanogen cobalt
The derivative of amine element and other cobalamins and the material that can in vivo discharge/generate cobalamin.
Health food of the present invention can be made into conventional tablet, pill, electuary, oral liquid, chewable tablet, soft capsule
The peroral dosage forms such as agent, hard capsule, pulvis and granule.
Heretofore described auxiliary material is selected from filler, wetting agent, adhesive, disintegrant, lubricant, flavouring, stabilization
Agent, embedded object, the one or more combination being coated in pre-mixing agent, food coloring.
Filler of the present invention includes that starch, soluble starch, dextrin, maltodextrin, farina, corn form sediment
Powder, wheaten starch, D-mannital, calcium monohydrogen phosphate, calcium phosphate dibasic anhydrous, maltose, xylitol, D-sorbite, microcrystalline cellulose
One kind of element, isomaltoketose, milk powder, low-substituted hydroxypropyl cellulose, sucrose, glucose, lactose, pregelatinized starch etc. is several
Kind.
Wetting agent of the present invention includes purified water and ethanol, described adhesive include hydroxypropyl methyl cellulose,
PVP, hydroxypropylcellulose, carmethose, starch, methylcellulose, ethyl cellulose, gelatin, polyethylene glycol, pre- glue
Change the one of which or several such as starch, sucrose, glucose.
Disintegrant of the present invention includes starch, carboxyrnethyl starch sodium, PVPP, cross-linked carboxymethyl cellulose sodium, low
Substitution hydroxypropylcellulose, sodium acid carbonate and citric acid etc. it is therein one or more, described lubricant includes magnesium stearate, hard
Resin acid, talcum powder, silica, hydrogenated vegetable oil, polyethylene glycol, lauryl sodium sulfate, Compritol 888 ATO, stearic richness horse
Sour sodium etc. it is therein one or more.
Flavouring of the present invention it is therein a kind of including Fruit powder, flavoring essence, high sweetener, acid etc. or
Several, described Fruit powder includes orange powder, lemon powder, cherry powder, apple powder, strawberry powder, strawberry powder, kiwi fruit powder, tangerine powder, sand
Spine fruit powder, green plum fruit powder, mango fruit powder, mulberry powder, hawthorn fruit powder, watermelon fruit powder, pineapple fruit powder, blueberry powder, honey peach
Fruit powder, "Hami" melon fruit powder, grape fruit powder, vanilla fruit powder, pomegranate fruit powder, rose fruit powder etc. it is therein one or more.
Flavoring essence of the present invention include vanilla, orange flavor, milk flavour, flavoring apple essence, grape essence,
Strawberry essence, flavoring pineapple essence, peach flavor, Hami melon essence, lemon extract, cherry essence, sweet corn flavor, banana incense
Essence, grape essence, flavoring rose essence, blackcurrant essence, green apple essence, mango essence, blue or green mango essence, flavoring orange essence, fragrant citrus
Essence, pyrus nivalis essence, green plum essence, blueberry flavor, red bayberry essence, shaddock essence, flavoring pineapple essence, guava essence, passion fruit
Essence, Chinese grooseberry essence, kiwi flavor, watermelon essence, pawpaw essence, durian essence, lychee flavor, hawthorn essence, olive
Essence, flavoring mulberry essence etc. it is therein one or more.
High sweetener of the present invention includes Sucralose, Aspartame, mogroside, neotame, stevioside, institute
The acid stated includes citric acid, malic acid, lactic acid, tartaric acid and fumaric acid, and described food coloring includes burnt sugar coloring, cape jasmine
Yellow, curcumin and chlorophyll, chilli orange, capsanthin, Grape Skin be red, carmine and its aluminum lake, sunset yellow and its aluminum lake,
Light blue and its aluminum lake, indigo and its aluminum lake, beet red, natural amaranth, gardenia blue, plant carbon black, iron oxide black, oxidation
Iron oxide red, black soya bean are red, the one of quinoline yellow, lycopene, Monascus color, yellow ferric oxide, cacao pigment, safflower yellow, monascus yellow pigment etc.
Plant or several.
Stabilizer of the present invention includes dibutyl hydroxy toluene (BHT), butylated hydroxy anisole (BHA), vitamin
C, described embedded object includes beta-schardinger dextrin, alpha-cyclodextrin, gamma-cyclodextrin, dextrin, starch, modified food starch, sucrose, wheat
Bud dextrin, gum arabic etc. it is therein one or more.
The important physiologic function of vitamin E is to promote female, androgen secretion, improves hormone concentration, promotes fertility, can be used
In treatment threatened abortion and habitual abortion, male sterility etc. is prevented and treated；Vitamin E is splendid free radical scavenger：It is exposed to
Many cell enzyme systems of environmental factor, Mitochondrial electron transmission may all generate oxygen type free base and other free radicals, dimension life
Plain E is oxidized to tocopherol by itself, protects cells from oxidation, prevents free radical or oxidant to many insatiable hungers in cell membrane
With the damage that aliphatic acid, film are rich in the protein component and cytoskeleton and nucleic acid of dredging base；Vitamin E can also excite siberian crabapple
System function, plays immunologic function；Additionally, vitamin E has reduction cholesterol, suppresses the effect of the vascular protections such as platelet aggregation.
Vitamin B12Various metabolic processes are participated in the form of coenzyme, promotes the formation and transfer of methyl, participate in some changes
The isomerization of compound, the reducing condition for maintaining SH bases, promote the synthesis of DNA and protein, promote the maturation of cell, maintain
The normal function of nerve fiber, clinically can be used for treatment pernicious anaemia, liver diseases, neuritis, neuralgia etc..Vitamin
B12During shortage, main influence hemopoietic system and nervous system are also relevant with the disease such as senile dementia, depression.Additionally, vitamin
B12The utilization rate of folic acid can be increased, promote three major nutrient metabolism.Vitamin B12Shortage is that a global nutrient lacks
Weary disease, its incidence of disease studies discovery crowd's vitamin B more than the height estimated12Insufficient rate is 3~29%.
Folic acid is body cell growth and material necessary to breeding.Human body lacks the exception that folic acid can cause red blood cell,
The increase of immature cell, anaemia and white blood cell are reduced.Folic acid is through dihyrofolate reductase and vitamin B12Catalytic action
After form tetrahydrofolic acid, transmit one carbon unit, many important reactions and nucleic acid synthesis etc. in vivo are participated in, including offer-CH3
Homocysteine (Homocysteine, Hcy) is methylated again, so as to promote the metabolism of Hcy to change, treat Hcy mass formed by blood stasis high.
From the point of view of the result of study that current documents and materials are accumulated for many years with us, folic acid is the confrontation elevated most effective intervention hands of Hcy
Section, and Hcy mass formed by blood stasis high is the independent hazard factor of cardiovascular and cerebrovascular disease.
Folic acid or the indispensable nutrient of embryo growth and development, when pregnant woman's shortage folic acid is likely to result in fetal birth
There is under-weight, harelip, heart defect etc..If lacking folic acid in pregnancy is first 3 months, fetal neural tube can be caused to develop
Defect, causes deformity.Therefore, prepare the women of pregnancy, can begin to take 400~500 μ g folic acid daily before pregnancy.And I
Folic acid intensified foodstuff is not carried out by state, custom of the masses without the conscious Supplement of folic acid from food, overall serum folate levels compared with
It is low, along with Chinese family is accustomed to high-temperature cooking food, folic acid and vitamin B12Easily destroyed, its effective intake is not enough.
Health food of the present invention, the definite raw material of screening effect carries out scientific composition, so that it is guaranteed that the work(of product
Effect.By anti-oxidant, protect biomembrane to be attacked from free radical, be beneficial to beautifying and anti-aging；By Supplement of folic acid and vitamin E
It is favorably improved the fecundity and prevention Fetal neurotubules malformation of Women of childbearing age；By Supplement of folic acid, vitamin B12Can drop
Low Hcy, protects blood vessel endothelium, helps to prevent middle aged and aged women disease of cardiovascular system.Compared with existing product, the present invention is protected
Health food is a kind of better, more accurately vitamin supplement product.With reference to embodiment to embodiments of the present invention
It is further described.
Brief description of the drawings
Fig. 1 is health food wet granulation technology flow chart of the present invention；
Fig. 2 is health food vertical compression process route chart of the present invention；
Fig. 3 is health food embedding+vertical compression process route chart of the present invention.
Specific embodiment
The preparation of the health food conventional tablet of the present invention of embodiment 1.
Prescription
Preparation technology：Take 50% ethanol solution of PVP K30 and prepare composite adhesives, then vitamin E is added into adhesive
In stir, it is standby.Separately take vitamin B12, folic acid, Sucralose mix with pregelatinized starch, sieve, add milk fragrant
Essence, carboxyrnethyl starch sodium, dextrin mixing, addition prepare containing vitamin E adhesive softwood, the granulation of 24 mesh sieves, 55 DEG C dry
Dry 2h, 24 mesh sieve whole grains add magnesium stearate mixing, compressing tablet.Pre-mixing agent will be coated and be configured to solution, plain piece is coated, that is, be obtained
The tablet of health food of the present invention.
In order to prove the anti-oxidant of health products of the present invention, anti-aging, reproductive health care effect, we devise following experiment,
Mainly to superoxide dismutase (SOD), reductive glutathione (GSH), alpha-tocopherol, Endothelin in experimental animal serum
(ET-1) and nitric oxide (NO) content, investigate the efficacy effect of health products of the present invention.
Experimental technique：48 30~35g, 5 sexual maturing period at monthly age female KM mouse are grouped at random, respectively blank pair
According to group, take health products (embodiment 1) low dose group, middle dose group, high dose group, every group 12, sub-cage rearing, free water
Diet.Wherein, except the daily gavage respective volume solvent of blank control group, low dose group vitamin E+folic acid+vitamin B12(15+
0.05+0.0005) mg/kg/d gavages give this health products, middle dose group vitamin E+folic acid+vitamin B12(30+0.1+
0.001) mg/kg/d gavages give this health products, high dose group vitamin E+folic acid+vitamin B12(60+0.2+0.002)mg/
Kg/d gavages give this health products, continue 8 weeks.Put to death preceding fasting in 12 hours and can't help water.Mouse abdominal aorta blood is taken, 4h is stood
Afterwards, centrifugation (4000r/min, 10min/) take supernatant freezing it is standby.Respectively to superoxide dismutase in mice serum (SOD),
Reductive glutathione (GSH), estradiol, the content of progesterone are measured.
Experimental result：
Mice serum SOD and the GSH measurement result of table 1
Compare with blank control group,#P<0.05,##P<0.01
The mice serum estradiol of table 2 and progesterone measurement result
Compare with blank control group,#P<0.05,##P<0.01
By 1~table of table 2 as can be seen that compared with blank group, taking health products group SOD in serum and GSH levels significantly being raised,
Show that antioxidant ability of organism strengthens；Serum estradiol and progesterone level are significantly raised simultaneously, and endometrium receptivity increases, and has
Beneficial to embryo nidation and development, the reproductive function to animal is beneficial.
The preparation of the health food soft capsule of the present invention of embodiment 2.
Prescription
Preparation technology：By beeswax add soybean oil in, 50 DEG C heating, dissolve beeswax, place to room temperature, take vitamin E,
Folic acid, vitamin B12Suspension is made in addition soybean oil, it is standby.Separately take gelatin, purified water, burnt sugar coloring, P-hydroxybenzoic acid
Ester is configured to glue, and obtained suspended matter is made into soft capsule with pellet press pelleting, through shaping, after washing ball and dried process, i.e.,
The soft capsule of health food of the present invention is obtained.
The preparation of the health food chewable tablets of the present invention of embodiment 3.
Prescription
Preparation technology：Take 60% ethanol solutions of Hydroxypropyl methylcellulose E5 and prepare composite adhesives, then vitamin E is added viscous
Stirred in mixture, it is standby.Separately take vitamin B12, 5-methyltetrahydrofolate mix with microcrystalline cellulose, sieve, add sweet
Chrysanthemum glycosides, lemon extract, milk powder, xylitol mixing, addition prepare containing vitamin E adhesive softwood, 24 mesh sieves are pelletized,
55 DEG C dry 2h, and 24 mesh sieve whole grains add magnesium stearate mixing, and compressing tablet is the chewable tablets that health food of the present invention is obtained.
In order to prove that health products of the present invention have certain protection effect to disease of cardiovascular system, we devise following reality
Test, mainly to T-CHOL (TC), low-density lipoprotein (LDL), the finger of blood vessel endothelium defencive function in experimental animal serum
The content of mark Endothelin (ET-1) and nitric oxide (NO) is measured, and experimental animal blood pressure is monitored in experimentation to examine
Examine the efficacy effect of health products of the present invention.
Experimental technique：40 12~13 week old SHR rats are grouped at random, are divided into model group, are taken health products (embodiment
3) low dose group, middle dose group, high dose group, every group 10, male and female half and half have 10 close WKY rats of week old to make in addition
It is blank control group, male and female half and half, sub-cage rearing, free water diet.Wherein, except WKY groups are fed with normal diet, remaining group is equal
Fat homomethionin feed high is fed with, after continuing 4 weeks, model group and the daily gavage respective volume solvent of WKY groups, low dose group dimension life
Plain E+5- methyl tetrahydrofolates+vitamin B12(20+0.1+0.002) mg/kg/d gavages give this health products, middle dose group dimension life
Plain E+5- methyl tetrahydrofolates+vitamin B12(40+0.2+0.004) mg/kg/d gavages give this health products, the dimension life of high dose group
Plain E+5- methyl tetrahydrofolates+vitamin B12(80+0.4+0.008) mg/kg/d gavages give this health products, continue 6 weeks, while
Blood pressure (0w), the preceding blood pressure (6w) of execution before gavage are determined, preceding fasting in 12 hours is put to death and be can't help water.Rat aorta blood is taken, it is quiet
After putting 4h, it is standby that centrifugation (4000r/min, 10min/) takes supernatant freezing.Respectively to T-CHOL in serum (TC), low density lipoprotein
The content of albumen (LDL) and homocysteine (HCY) is measured.
Experimental result：
Rat ET-1 and the NO measurement result of table 3
Compare with blank control group,#P<0.05,##P<0.01, compare with model group,*P<0.05,**P<0.01
The rat blood pressure measurement result of table 4
Compare with blank control group,#P<0.05,##P<0.01
The Serum TC of table 5, LDL and HCY measurement results
Compare with blank control group,#P<0.05,##P<0.01, compare with model group,*P<0.05,**P<0.01
By 3~table of table 5 as can be seen that compared with model group, the reduction of the level of Serum ET -1, NO levels increase, and show endothelium
Degree of injury has more apparent improvement compared with model group, and this is consistent with the protection of ecs function conclusion of known folic acid.Model group blood
Clear TC, LDL and HCY value is significantly raised, and taking health products high dose group serum TC, LDL and HCY levels substantially reduces, and
In, low dose group have certain lipid-loweringing trend.Do not taken while taking health products group animal mean blood pressure after gavage 6w and being less than
Group, antihypertensive effect is not notable, the antihypertensive effect for having 5~10mmHg to health products group.
Generally, the health products are to risk factors of cardiovascular diseases blood pressure, blood fat and HCY, endothelial function index NO, ET-1
Level has different degrees of improvement result, further demonstrates the efficacy effect of health products of the present invention.
Other safety toxicology experiment shows that this health products is safe and free of toxic and side effects.
The preparation of the health food granule of the present invention of embodiment 4.
Prescription
Preparation technology：Sucrose was crushed into 100 mesh sieves standby；Take 50% ethanol solution of PVP K30 and be configured to bonding
Agent, then will be stirred in vitamin E addition adhesive, it is standby.Separately take vitamin B12, folic acid mix with sucrose, sieve, then add
Enter apple powder, flavoring apple essence, carboxyrnethyl starch sodium, maltodextrin mixing, it is soft containing vitamin E adhesive system that addition is prepared
Material, the granulation of 24 mesh sieves, 55 DEG C dry 2h, and 24 mesh sieve whole grains are obtained the granule of health food of the present invention.
The preparation of the health food pulvis of the present invention of embodiment 5.
Prescription
Preparation technology：Above-mentioned each group is placed in mixer and is well mixed, then dispensed with racking machine, that is, be obtained
The pulvis of health food of the present invention.
Claims (8)
1. a kind of health food or nutritious supplementary pharmaceutical, by vitamin E, folic acid and vitamin B12And appropriate amount of auxiliary materials composition.
2. health food according to claim 1, it is characterised in that：The content of vitamin E is 10~500mg, preferably
15~200mg；The vitamin B12Content be 5~100 μ g, preferably 5~20 μ g；The folate content is 0.2~2.0mg,
It is preferred that 0.4~1.0mg.
3. health food according to claims 1 to 2, it is characterised in that：The vitamin E includes natural VE (D-
Alpha-tocopherol, D- α-D-α-tocopherol acetate, D- α-tocopheryl succinate), dl- α-D-α-tocopherol acetate, dl- alpha-tocopherols, vitamin E
The forms such as calcium succinate.
4. health food according to claims 1 to 2, it is characterised in that：The folic acid includes folic acid, 5- methyl tetrahydrochysene leaves
Acid, calcium leucovorin, folate and its active metabolite, i.e., including artificial synthesized and plant extract source various leaves
Sour form.
5. health food according to claims 1 to 2, it is characterised in that：The vitamin B12Including cobalamin, Mecobalamin
Element, 5 '-deoxyadenosyl cobalamin, hydroxocobalamine, cyanocobalamin.
6. health food according to claims 1 to 5, it is characterised in that：Described auxiliary material be selected from filler, wetting agent,
Adhesive, disintegrant, lubricant, flavouring, food coloring, stabilizer, embedded object, coating pre-mixing agent etc. are therein a kind of or several
Plant combination.
7. health food according to claims 1 to 6, it is characterised in that：Described health food is prepared to oral system
Agent, including conventional tablet, pill, electuary, oral liquid, chewable tablet, soft capsule, hard capsule, pulvis and granule etc..
8. the multivitamin composition described in any one of claim 1~7 can be used for beautifying and anti-aging, Women of childbearing age in preparation
Purposes in the health food of healthy reproduction and auxiliary protection middle and aged women cardiovascular system health.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710140768.2A CN106901378A (en) | 2017-03-10 | 2017-03-10 | A kind of health food suitable for women |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710140768.2A CN106901378A (en) | 2017-03-10 | 2017-03-10 | A kind of health food suitable for women |
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Family
ID=59187756
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110122879A (en) * | 2018-02-08 | 2019-08-16 | 越洋医药开发(广州)有限公司 | It is a kind of for Supplement of folic acid and the vitamin combination health food of vitamin E and preparation method thereof |
| CN110786516A (en) * | 2018-08-01 | 2020-02-14 | 深圳奥萨医药有限公司 | Nutritional supplement suitable for perimenopausal women |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1271579A (en) * | 1999-03-18 | 2000-11-01 | 布里斯托尔-迈尔斯斯奎布公司 | Compound vitamin for health of cardiovascular |
| WO2003059274A2 (en) * | 2002-01-14 | 2003-07-24 | Bristol-Myers Squibb Company | Vitamin formulation for cardiovascular health |
| CN101897706A (en) * | 2009-05-27 | 2010-12-01 | 北京奥萨医药研究中心有限公司 | Composition containing folic acid and B vitamins and applications thereof |
-
2017
- 2017-03-10 CN CN201710140768.2A patent/CN106901378A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1271579A (en) * | 1999-03-18 | 2000-11-01 | 布里斯托尔-迈尔斯斯奎布公司 | Compound vitamin for health of cardiovascular |
| WO2003059274A2 (en) * | 2002-01-14 | 2003-07-24 | Bristol-Myers Squibb Company | Vitamin formulation for cardiovascular health |
| CN101897706A (en) * | 2009-05-27 | 2010-12-01 | 北京奥萨医药研究中心有限公司 | Composition containing folic acid and B vitamins and applications thereof |
Non-Patent Citations (4)
| Title |
|---|
| 何卫珍: "《新编孕产期营养百科》", 31 October 2014, 中国纺织出版社 * |
| 李正化: "《药物化学》", 31 January 2000, 人民卫生出版社 * |
| 王志文: "重组人类促红细胞生成素防治早产儿贫血疗效观察", 《临床心身疾病杂志》 * |
| 蔡慧珍: "《孕期这样吃健康又益智》", 30 November 2012, 新世界出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110122879A (en) * | 2018-02-08 | 2019-08-16 | 越洋医药开发(广州)有限公司 | It is a kind of for Supplement of folic acid and the vitamin combination health food of vitamin E and preparation method thereof |
| CN110786516A (en) * | 2018-08-01 | 2020-02-14 | 深圳奥萨医药有限公司 | Nutritional supplement suitable for perimenopausal women |
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