CN110338425A - A kind of nutritional supplement protecting osteoporosis - Google Patents

A kind of nutritional supplement protecting osteoporosis Download PDF

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Publication number
CN110338425A
CN110338425A CN201810305059.XA CN201810305059A CN110338425A CN 110338425 A CN110338425 A CN 110338425A CN 201810305059 A CN201810305059 A CN 201810305059A CN 110338425 A CN110338425 A CN 110338425A
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vitamin
nutritional supplement
essence
osteoporosis
content
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徐希平
张磊
于多
陈平
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AUSA PHARMED Ltd
BEIJING AOSA MEDICINE RESEARCH CENTRE Co Ltd
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AUSA PHARMED Ltd
BEIJING AOSA MEDICINE RESEARCH CENTRE Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The present invention relates to a kind of nutritional supplements made of 100-800ug vitamin A, 5-20ug vitamin B12,1.5-10ug vitamin D and 5-150mg vitamin E and preparation method thereof, the nutritional supplement has the function of protection osteoporosis, is particularly suitable for gestational patients.Composition provided by the invention is not limited to that nutriment or health food is made, it can also be used to prepare drug.

Description

A kind of nutritional supplement protecting osteoporosis
Technical field
The present invention relates to the nutritional supplements that a kind of pair of osteoporosis has protective action, contain vitamin A, vitamin B12, vitamin D and vitamin E, the replenishers are also suitable for that health food is made.
Background technique
Osteoporosis is one kind bone density as caused by many reasons and bone mass decline, and bone micro-structure is destroyed, caused Bone brittleness increases, to be easy to happen the systemic osteopathy of fracture.Osteoporosis is divided into primary and secondary two major class.It is former Hair property osteoporosis is divided into Postmenopausal Osteoporosis (I type), senile osteoporosis (II type) and idiopathic sclerotin again Three kinds of loose (including juvenile).Zhang Zhihai discloses -50 years old 40 years old age brackets, and women osteoporosis disease incidence is 6.37% ± 2.39%, the loose disease incidence of male is 4.11% ± 1.70%；- 60 years old 50 years old age brackets, the loose disease incidence of women are 21.75% ± 5.96%, male is 12.90% ± 6.35%；- 70 years old 60 years old age brackets: women is 46.38% ± 12.03%, Nan Xingwei 19.90% ± 8.31%；- 80 years old 70 years old age brackets: women is 64.32% ± 9.79%, and male is 28.97% ± 7.63%； - 90 years old 80 years old age brackets: women is 76.74% ± 5.28%, male 39.78% ± 15.09% (Zhang Zhihai etc., China's Mainland Area with -2.5SD be diagnosis developing osteoporosis rate review of literature Journal of Sex Research, Chinese osteoporosis magazine, 2015 21 Roll up 1 phase, 1-7).
Vitamin A is also known as retinol or antiophthalmic factor, is one of nutrient needed by human.Vitamin A only exists In animal food, as not yet found vitamin A in plant tissue in the liver of mammal and fish.In traditional research In, the bioactivity of vitamin A be mainly reflected in the growth of maintenance body, maintenance epidermis is complete, maintain bone and embryonic development, Maintain the normal of hemoposieis and vision.Progress in recent years shows that vitamin A has enhancing body's immunity, anti-grease Matter peroxidative activity, adjusts the multiple biological activities functions such as fatty storage at the anti-infective function of enhancing.The weight of vitamin A deficiency It is influencing first is that damage to epithelial growth and differentiation, causes the careful property of internal body and external skins to decline, be easy after It is even dead to send out bacterium infection.Report that vitamin A deficiency can lead to the decline of dark adaptation ability, epithelial cell hyperkeratosis, tear Gland, (including mucous membrane and slurries membrane part) atrophy, corneal epithelium and the xeroma of Parotid and submandibular gland body of gland and cause dry eyes Disease.Generally there is the increase of squamous keratinocyte in vitamin A deficiency, and granular cell and mucous secreting cell ratio decline phenomenon, can Conjunctiva is set to lose goblet cell, conjunctival epithelium angling and squamatization.In addition, the animal of vitamin A deficiency can cause multiplicity Septicemia, and have very high case fatality rate.It can be seen that vitamin A is indispensable to human body.
The main Physiological Function of vitamin A: 1. vitamin As are the raw materials for synthesizing visual purple, which is a kind of photosensitive object Matter is present in retina.The A that is deficient in vitamin cannot synthesize enough visual purples, will lead to yctalopia.2. helping to protect Skin, nose, throat, respiratory apparatus inner membrance, the health of digestive system and urogenital tract epithelial tissue, and from infect.3. Maintain the growth and development of bone, tooth jointly with nutrients such as vitamin D and calcium.4. preventing Thyroid Gland Swell.5. cholesterol closes At the pure and mild required composition of glycogen institute of cortex.
Vitamin B12 is also known as cobalamin or cyanogen cobalt element.It is a kind of B race dimension life being made of the porphyrins containing cobalt Element.B12 is primarily present in meat, and the soybean and some herbal medicine in plant also contain B12, and enteric bacteria can synthesize, therefore Have no lack of under normal circumstances, but the B12 person that is disease of digestive tract be easy the vitamin lacked and red blood cell generate it is indispensable Important element, if there is a serious shortage of will lead to pernicious anaemia.Vitamin B12 is widely present in animal foodstuff.And its form It can not be absorbed by the body.In addition, vitamin B12 is also the vitamin uniquely containing necessary minerals, take on a red color because of due to containing cobalt, also known as Red vitamin is a small number of coloured vitamins.Though vitamin B12 belongs to B groups of vitamins, it can be housed in liver, use up storage After amount, by more than half a year just will appear shortage symptom.
Tieing up raw D is a kind of liposoluble vitamin, is also seen as a kind of hormone precursor for acting on Ca,P metabolism, it with Sunlight has substantial connection, so being called " sunlight vitamin ".Vitamin D is that family's A, B, C, D ring structure is identical, but side chain is different A kind of compound general name, the architectural source of A, B, C, D ring is in the penta hydrogen alkene phenanthrene ring structure of ring of steroids, the dimension being currently known Raw at least 10 kinds of element D, but most importantly calciferol (vitamin D2) and vitamine D3 (Vitamin D3).Vitamine D3 There is following physiological function: 1, improving absorption of the body to calcium phosphorus, plasma calcium and the level of blood plasma phosphorus is made to reach degree of saturation.2, promote Into growth and bone calcification, promote tooth sound；3, increase the absorption of phosphorus by intestinal wall, and increase the suction of phosphorus by renal tubule It receives；4, the normal level of citrate in blood is maintained；5, prevent amino acid from losing by kidney.Calciferol promotes small intestine glutinous Absorption and reabsorption phosphorus of the film brush border to calcium improve blood calcium, serium inorganic phosphorus concentration, cooperate with parathormone, calcitonin, promote Calcium phosphate is discharged into old bone, maintains and adjust the normal concentration of plasma calcium, phosphorus.Calciferol promotes calcific deposit in new bone formation portion Position, makes citrate take advantage of the occasion in bone, promotes bone calcification and function of osteoblast and osteoid tissue mature.
Vitamin E is a kind of liposoluble vitamin, also known as tocopherol, is one of most important antioxidant.It is dissolved in fat It is not soluble in water in the organic solvents such as ethyl alcohol, heat, acid are stablized, it is sensitive to oxygen, it is insensitive to heat.Currently, vitamin E by It is widely used as the nutritional supplement and antioxidant of medicine, cosmetics and food industry, becomes scientists from all over the world and gos deep into extensively The object of research.Vitamin E physiologic function is primarily as free radical scavenger.It is exposed to many thin of various environmental factors Born of the same parents' enzyme system, Mitochondrial electron transmitting are all difficult to generate oxygen type free base and other free radicals, vitamin E due to its is fat-soluble Cell membrane is directly protected in free radical detoxification system of defense, prevents and treats free radical or oxidant to polyunsaturated fat in cell membrane The damage of sour, film the protein component and cytoskeleton and nucleic acid rich in sulfydryl.Vitamin E and free radical are raw after reacting At tocopherol sulfydryl free radical also tocopherol can be reduced to by vitamin C, glutathione and ubiquinone again.
Vitamin E can promote sex hormone to secrete, and increase man's sperm motility and quantity；Increase woman's female hormone concentration Height improves fecundity, prevention of miscarriage, it may also be used for prevention and treatment male sterility, burn, frostbite, capillary hemorrhage, climacteric The fermentation such as syndrome, beauty.In recent years it has also been found that vitamin E can inhibit the lipid peroxidation reaction in ocular lens body, make tip Blood vessel dilatation improves blood circulation, pre- myopia prevention occurrence and development.
The physiological function of vitamin E: 1, it is a kind of powerful antioxidant, can effectively stop fatty acid in food and alimentary canal It is rancid, protect cells from unsaturated fat acid oxidase generation harmful substance injury.2, it is fabulous radicals scavenging Agent can protect biomembrane to attack from free radical, effective anti-senility nutrient.3, improve body immunity.4, it keeps blood red The integrality of cell promotes the biosynthesis of erythrocyte.5, it is the required promotive factor of cellular respiration, lung tissue can be protected to exempt from By air pollution.6, pre- fat cardiovascular disease.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of battalion of protection osteoporosis more significantly more efficient than vitamin D Replenishers are supported, which is made of following composition:
1) 100-800 μ g vitamin A；
2) 5-20ug vitamin B12；
3) 1.5-10ug vitamin D；
4) 5-150mg vitamin E；
5) auxiliary material.
Further, in nutritional supplement provided by the invention, the preferred content of vitamin A is 160-800ug, dimension life The preferred content of plain B12 is 5-10ug, and the preferred content of vitamin D is 5-10ug, and the preferred content of vitamin E is 50- 100mg。
In the present invention, the B12 includes cobalamin and cyanocobalamin.
In the present invention, the vitamin D preferred vitamin D2 (vitamin D2) and vitamine D3.
Nutritional supplement provided by the invention can be made into conventional tablet, chewable tablet, soft capsule, hard capsule, pulvis And the peroral dosage forms such as granule.
In the present invention, the auxiliary material is selected from filler, wetting agent, adhesive, disintegrating agent, lubricant, corrigent, steady Determine one or more of agent, embedded object, coating pre-mixing agent, edible pigment combination.
Wherein, filler of the present invention include starch, soluble starch, dextrin, maltodextrin, potato starch, It is cornstarch, wheaten starch, D-mannital, calcium monohydrogen phosphate, calcium phosphate dibasic anhydrous, maltose, xylitol, D-sorbite, micro- Crystalline cellulose, isomaltoketose, milk powder, low-substituted hydroxypropyl cellulose, sucrose, glucose, lactose, pregelatinized starch, malt paste The one or more of essence etc..
Wetting agent of the present invention includes purified water and ethyl alcohol, the adhesive include hydroxypropyl methyl cellulose, Povidone, hydroxypropylcellulose, carmethose, starch, methylcellulose, ethyl cellulose, gelatin, polyethylene glycol, pre- glue It is one of or several to change starch, sucrose, glucose etc..
Disintegrating agent of the present invention includes starch, carboxyrnethyl starch sodium, crospovidone, cross-linked carboxymethyl cellulose sodium, low Replace hydroxypropylcellulose, sodium bicarbonate and citric acid etc. one such or several, the lubricant includes magnesium stearate, hard Resin acid, talcum powder, silica, hydrogenated vegetable oil, polyethylene glycol, lauryl sodium sulfate, Compritol 888 ATO, stearic rich horse Sour sodium etc. is one such or several.
Corrigent of the present invention include Fruit powder, edible essence, high sweetener, acid etc. it is one such or Several, the Fruit powder includes orange powder, lemon powder, cherry powder, apple powder, strawberry powder, strawberry powder, kiwi fruit powder, tangerine powder, sand Spine fruit powder, green plum fruit powder, mango fruit powder, mulberry powder, hawthorn fruit powder, watermelon fruit powder, pineapple fruit powder, blueberry powder, honey peach Fruit powder, "Hami" melon fruit powder, grape fruit powder, vanilla fruit powder, pomegranate fruit powder, rose fruit powder etc. are one such or several.
Edible essence of the present invention include vanilla, orange flavor, milk flavour, flavoring apple essence, grape essence, Strawberry essence, flavoring pineapple essence, peach flavor, Hami melon essence, lemon extract, cherry essence, sweet corn flavor, banana incense Essence, grape essence, grape essence, flavoring rose essence, blackcurrant essence, green apple essence, mango essence, green mango essence, orange Essence, fragrant citrus essence, pyrus nivalis essence, strawberry essence, green plum essence, blueberry flavor, red bayberry essence, shaddock essence, flavoring pineapple essence, Guava essence, passion fruit essence, Chinese grooseberry essence, cherry essence, kiwi flavor, watermelon essence, pawpaw essence, "Hami" melon Essence, durian essence, lychee flavor, hawthorn essence, olive essence, flavoring mulberry essence etc. are one such or several.
High sweetener of the present invention includes Sucralose, Aspartame, mogroside, neotame, stevioside, institute The acid stated includes citric acid, malic acid, lactic acid, tartaric acid and fumaric acid, and the edible pigment includes burnt sugar coloring, cape jasmine Yellow, curcumin and chlorophyll, chilli orange, capsanthin, Grape Skin be red, carmine and its aluminum lake, sunset yellow and its aluminum lake, Brilliant blue and its aluminum lake, indigo and its aluminum lake, beet red, natural amaranth, gardenia blue, plant carbon black, iron oxide black, oxidation Iron oxide red, semen sojae atricolor be red, quinoline yellow, lycopene, Monascus color, yellow ferric oxide, cacao pigment, safflower yellow, monascus yellow pigment etc. one Kind is several.
Stabilizer of the present invention includes vitamin E, dibutyl hydroxy toluene (BHT), butylated hydroxy anisole (BHA), vitamin C, the embedded object include beta-cyclodextrin, alpha-cyclodextrin, gamma-cyclodextrin, dextrin, starch, edible denaturation Starch, sucrose, maltodextrin, gum arabic etc. are one such or several.
The vitamin of nutritional supplement screening function collaboration provided by the invention carries out scientific composition, so that it is guaranteed that product Effect has pre- preventing bone rarefaction non-by supplement optimal dose vitamin B12, vitamin D and vitamin E and vitamin A Normal significant curative effect has significant adjuvant treatment effect, and the curative effect of the nutritional supplement for patients with osteoporosis It is significantly stronger than the independent or any united application effect of constituent.Nutritional supplement provided by the invention is particularly suitable for pre- Anti- gestation osteoporosis, is ideal treatment adjuvant drug for pregnant sufferers of osteoporosis face.
The present invention will be further described With reference to embodiment, not limitation of the invention, all according to this The same replacement of any this field that summary of the invention carries out, all belongs to the scope of protection of the present invention.
Specific embodiment
Embodiment 1: vitamin A vitamin B12 Vitamin D Vitamin E tablet
Component:
First by 160ug vitamin A, 5ug vitamin B12,5ug vitamin D and 50mg vitamin E and 76mg microcrystalline cellulose It mixes, 16mg croscarmellose sodium is added in obtained mixed liquor, obtains mixed powder.It is poly- that 24mg is added in mixed powder The bonding of 25ml mixed liquor is added uniformly by every 100mg mixed powder, with hand in the mixed liquor for tieing up ketone K30 and wetting agent (water or ethyl alcohol) The i.e. bulk state for holding agglomerating touching is advisable, and crosses the granulation of 18 meshes.Above-mentioned wet granular is dried, temperature is 60 degree, drying time 4 Hour, moisture refers to that content control is being less than or equal to 7%.Dry particle crosses 18 meshes, obtains dry particl.It is mixed that magnesium stearate is added Close 10 minutes to obtain total hybrid particles.Total hybrid particles are subjected to tabletting, are obtained containing vitamin A vitamin B12 vitamin D and dimension The tablet of raw element E.
Embodiment 2: vitamin A vitamin B12 Vitamin D Vitamin E soft capsule
Component:
Preparation method: beeswax is added in soybean oil, and 50 DEG C of heating are dissolved beeswax, placed to room temperature, take vitamin A, Vitamin B12, vitamin D and vitamin E are added in soybean oil and suspension are made, spare.Separately take gelatin, purified water, burnt sugar coloring, P-hydroxybenzoate is configured to glue, and soft capsule is made with pellet press pelleting in suspended matter obtained, is formed, and washes ball and does After dry processing, the soft capsule is obtained.
Embodiment 3: vitamin A vitamin B12 Vitamin D Vitamin E hard capsule
Component:
Preparation method: vitaminAD is mixed with 20% microcrystalline cellulose, and sieving adds vitamin E, vitamin B12 Mixing, resulting raw mixture is mixed with the microcrystalline cellulose equal increments of surplus, and it is mixed to add lactose, magnesium stearate It closes, is then filled using Autocapsulefillingmachine, pharmaceutical composition of the present invention is obtained after polished processing Hard capsule.
Embodiment 4: vitamin A vitamin B12 Vitamin D Vitamin E lipid nano particle
Preparation: 1. weigh the pungent certain herbaceous plants with big flowers acid glyceride of 1.0g polyethylene glycol-8,1.0g cetearyl glucoside, and 92.5g is gone Ionized water is put into beaker, carries out 60 degree of heating water baths.
2. weighing 2.0g acetylation monoglyceride, the pungent certain herbaceous plants with big flowers acid glyceride of 0.5g carries out 60 degree of heating water baths.
3. vitamin A, vitamin B12, vitamin D and vitamin E are added after lipid in beaker is completely melt, heating is mixed It closes uniform.
4. water phase is added in above-mentioned system, stir evenly, sheared, while opening high pressure homogenizer and with 70 degree Deionized water is heated to 60 degree.
5. the high temperature emulsion system after shearing uniformly is injected high pressure homogenizer.
6. being cooled to room temperature to obtain complex lipid nanoparticle.
Protective effect of 5 compound of embodiment to osteoporosis rat
40 rats are randomly divided into 4 groups by weight: blank control group, model group, vitamin D group, compound group, Every group 10.In addition to blank control group intramuscular injection physiological saline, the equal hind leg of remaining each group replaces intramuscular injection dexamethasone 2.5mg/kg, often Week 2 times, totally 10 weeks.From 2nd week, blank control group, model group stomach-filling give physiological saline 10ml/kg, and vitamin D group gives dimension Raw element D0.5ug/ days, compound (the made tablet of embodiment 1 is dissolved in 1ml water, takes 100ul stomach-filling), once a day, even Continuous administration 12 weeks.
It was administered for the 12nd weekend, by 3% chloral hydrate anesthesia of rat, after abdominal aortic blood, centrifugation takes serum, with complete Automatic biochemistry analyzer is illustrated by kit, and the content of blood Ca, the inspection of para-nitro-pheneye phosphate method are surveyed with o-cresolphthalein complex copper method Survey serum alkaline phosphatase (ALP) content.After rat is put to death, dissociate double hind leg femurs, goes most surrounding tissue, femur is placed in small It on animal platform, is placed along platform long axis, measures femoral bmd (BMD) with Dual-energy X-rays absorptionmetry.Statistical test method It is examined using t.
As a result: as shown in table 1, compared with blank control group, model control group, vitamin D group rat femur bone density are aobvious Writing reduces (P < 0.01)；Type control group, vitamin D group rat femur bone density numerical value are close；With model control group, vitamin D Group compares, and compound group rat femur bone density significantly increases (P < 0.05).Osteoporosis is a kind of with stock intensity drop It is low that body is caused to suffer from the skeletal diseases that fracture risk increase is characterized.Bone strength size depends mainly on bone amount, BMD, that is, unit Bone mineral quantity contained by bone area is the main indicator for reacting bone strength and bone amount, is currently used for diagnosing osteoporosis, fracture The important indicator of Hazard degree assessment.1 experimental result of table shows that model control group rat femur BMD is remarkably decreased, and illustrates this experiment The method of use causes osteoporosis model to be successfully established；With model control group, vitamin D group rat femur bone density phase Than compound group rat femur bone density significantly increases, and illustrates that compound can be to BMD caused by Antiglucocorticoid It reduces, and the effect is significantly stronger than vitamin D and is used alone.
As shown in table 2, compared with blank control group, under model control group rat blood serum Ca content and ALP activity are significant It drops (P < 0.01)；Compared with model control group, compound group serum Ca content and ALP activity significantly increase (P < 0.05)；Compared with model control group, vitamin D group rat femur serum Ca content and ALP activity have raising trend, but difference It is not statistically significant；Compared with vitamin D group rat femur serum ALP activity, compound group serum ALP activity is significant It increases (P < 0.05).As known, the raising of calcium level facilitates the formation or calcification of new bone, while inhibiting strand calcium to blood Transfer reduces the loss of bone amount, treats osteoporosis.Serum levels of ALP is a kind of ectoenzyme of osteoblast, is played in blood circulation The effect of its promoting bone growing.Table 2 statistics indicate that, compound can significantly increase blood calcium, improve ALP activity, and effect is strong In the function and effect of vitamin D.
1 compound of table to the effect of osteoporosis rat femoral bmd (N=10)
Note: compared with normal group,**P<0.01；Compared with compound group,#P<0.05。
2 compound of table to osteoporosis rat Biochemical Indices In Serum influence (N=10)
Note: compared with normal group,**P < 0.01,*P<0.05；Compared with compound group,#P<0.05。

Claims (7)

1. a kind of nutritional supplement is made of following composition
1) 100-800 μ g vitamin A；
2) 5-20ug vitamin B12；
3) 1.5-10ug vitamin D；
4) 5-150mg vitamin E；
5) auxiliary material.
2. nutritional supplement according to claim 1, it is characterised in that the B12 includes cobalamin and cyanocobalamin.
3. nutritional supplement according to claim 1, it is characterised in that the vitamin D includes calciferol and Wei Sheng Plain D3.
4. nutritional supplement according to claim 1, it is characterised in that the content of the vitamin A is 160-800ug, dimension The content of raw element B12 is 5-10ug, and the content of vitamin D is 5-10ug, and the content of vitamin E is 50-100mg.
5. nutritional supplement according to claim 1, it is characterised in that the auxiliary material is selected from filler, wetting agent, glues Mixture, disintegrating agent, lubricant, corrigent, edible pigment, stabilizer, embedded object, coating pre-mixing agent etc. are one such or several Combination.
6. nutritional supplement described in -4 according to claim 1, it is characterised in that: the health food is prepared to ordinary tablet Agent, chewable tablet, soft capsule, hard capsule, pulvis and granule.
7. purposes of the nutritional supplement described in -5 in the product that preparation prevents, treats osteoporosis according to claim 1.
CN201810305059.XA 2018-04-08 2018-04-08 A kind of nutritional supplement protecting osteoporosis Pending CN110338425A (en)

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