CN110122879A - It is a kind of for Supplement of folic acid and the vitamin combination health food of vitamin E and preparation method thereof - Google Patents
It is a kind of for Supplement of folic acid and the vitamin combination health food of vitamin E and preparation method thereof Download PDFInfo
- Publication number
- CN110122879A CN110122879A CN201810127492.9A CN201810127492A CN110122879A CN 110122879 A CN110122879 A CN 110122879A CN 201810127492 A CN201810127492 A CN 201810127492A CN 110122879 A CN110122879 A CN 110122879A
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- CN
- China
- Prior art keywords
- vitamin
- folic acid
- health food
- pharmaceutic adjuvant
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 title claims abstract description 98
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title claims abstract description 65
- 235000019152 folic acid Nutrition 0.000 title claims abstract description 53
- 239000011724 folic acid Substances 0.000 title claims abstract description 52
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 229960000304 folic acid Drugs 0.000 title claims abstract description 46
- 229930003427 Vitamin E Natural products 0.000 title claims abstract description 32
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 239000011709 vitamin E Substances 0.000 title claims abstract description 32
- 235000019165 vitamin E Nutrition 0.000 title claims abstract description 32
- 229940046009 vitamin E Drugs 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 235000013402 health food Nutrition 0.000 title claims abstract description 20
- 229940088594 vitamin Drugs 0.000 title claims abstract description 19
- 229930003231 vitamin Natural products 0.000 title claims abstract description 19
- 235000013343 vitamin Nutrition 0.000 title claims abstract description 19
- 239000011782 vitamin Substances 0.000 title claims abstract description 19
- 150000003722 vitamin derivatives Chemical class 0.000 title claims abstract description 18
- 239000013589 supplement Substances 0.000 title description 7
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 238000007796 conventional method Methods 0.000 claims abstract 2
- 230000001070 adhesive effect Effects 0.000 claims description 12
- 239000000853 adhesive Substances 0.000 claims description 11
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 229920002472 Starch Polymers 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 239000000945 filler Substances 0.000 claims description 10
- 239000008107 starch Substances 0.000 claims description 10
- 235000019698 starch Nutrition 0.000 claims description 10
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 229920001353 Dextrin Polymers 0.000 claims description 7
- 239000004375 Dextrin Substances 0.000 claims description 7
- 235000019425 dextrin Nutrition 0.000 claims description 7
- 239000000314 lubricant Substances 0.000 claims description 7
- 239000011122 softwood Substances 0.000 claims description 7
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 6
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 6
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 6
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 6
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 4
- 235000019441 ethanol Nutrition 0.000 claims description 4
- 229940014144 folate Drugs 0.000 claims description 4
- -1 hydroxy-propyl Chemical group 0.000 claims description 4
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 235000020985 whole grains Nutrition 0.000 claims description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- 108010011485 Aspartame Proteins 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 230000002411 adverse Effects 0.000 claims description 2
- 239000000605 aspartame Substances 0.000 claims description 2
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 2
- 235000010357 aspartame Nutrition 0.000 claims description 2
- 229960003438 aspartame Drugs 0.000 claims description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- 229960000913 crospovidone Drugs 0.000 claims description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 229940041616 menthol Drugs 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 229940085605 saccharin sodium Drugs 0.000 claims description 2
- 230000014860 sensory perception of taste Effects 0.000 claims description 2
- 229940013618 stevioside Drugs 0.000 claims description 2
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 2
- 235000019202 steviosides Nutrition 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
- 229930195727 α-lactose Natural products 0.000 claims description 2
- 235000003599 food sweetener Nutrition 0.000 claims 2
- 239000003765 sweetening agent Substances 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- 241000195493 Cryptophyta Species 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000005864 Sulphur Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 239000004067 bulking agent Substances 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 229960001681 croscarmellose sodium Drugs 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims 1
- 239000010977 jade Substances 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 229940083542 sodium Drugs 0.000 claims 1
- 235000015424 sodium Nutrition 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 abstract description 7
- 230000012010 growth Effects 0.000 abstract description 5
- 210000003754 fetus Anatomy 0.000 abstract description 4
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 2
- 230000009469 supplementation Effects 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000000153 supplemental effect Effects 0.000 abstract 1
- 206010016880 Folate deficiency Diseases 0.000 description 4
- 208000010188 Folic Acid Deficiency Diseases 0.000 description 4
- 206010000234 Abortion spontaneous Diseases 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 208000015994 miscarriage Diseases 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 208000000995 spontaneous abortion Diseases 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 208000032170 Congenital Abnormalities Diseases 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 229920003081 Povidone K 30 Polymers 0.000 description 2
- 208000006399 Premature Obstetric Labor Diseases 0.000 description 2
- 206010036600 Premature labour Diseases 0.000 description 2
- 239000004376 Sucralose Substances 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
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- 230000036244 malformation Effects 0.000 description 2
- 210000001161 mammalian embryo Anatomy 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 210000000276 neural tube Anatomy 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 208000026440 premature labor Diseases 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 235000019408 sucralose Nutrition 0.000 description 2
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 208000002330 Congenital Heart Defects Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 208000031320 Teratogenesis Diseases 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 229930003761 Vitamin B9 Natural products 0.000 description 1
- 206010047631 Vitamin E deficiency Diseases 0.000 description 1
- WNQQFQRHFNVNSP-UHFFFAOYSA-N [Ca].[Fe] Chemical compound [Ca].[Fe] WNQQFQRHFNVNSP-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 229960004050 aminobenzoic acid Drugs 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000008122 artificial sweetener Substances 0.000 description 1
- 235000021311 artificial sweeteners Nutrition 0.000 description 1
- 230000007698 birth defect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 235000011132 calcium sulphate Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 206010009259 cleft lip Diseases 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 208000028831 congenital heart disease Diseases 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 230000004578 fetal growth Effects 0.000 description 1
- 150000002224 folic acids Chemical class 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 1
- 210000003716 mesoderm Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229940099908 multivitamin and calcium Drugs 0.000 description 1
- 201000000585 muscular atrophy Diseases 0.000 description 1
- 235000021096 natural sweeteners Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003539 oral contraceptive agent Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 230000004144 purine metabolism Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 235000019159 vitamin B9 Nutrition 0.000 description 1
- 239000011727 vitamin B9 Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of small dosage of folic acid and the vitamin combination health food of vitamin E and preparation method thereof, it can be used for promoting the growth and healthy development of pregnant woman pregnancy period fetus.The health food is made of folic acid, vitamin E and appropriate amount of auxiliary materials, by every capsule (piece) made of conventional method in pharmacy containing 100 ~ 400 μ g of folic acid, 5 ~ 150mg. of vitamin E the invention has the advantages that selected function related vitamin, for the crowd for needing these vitamins of specific supplemental, implement accurate nutritional supplementation.
Description
Technical field
The present invention relates to a kind of vitamin combination health foods, and more precisely, the present invention relates to one kind to be directed to pregnant woman
A kind of supplement small dosage of folic acid of design and the health food of vitamin E.The invention further relates to the preparation methods of said preparation.
Background technique
With the transformation of China's family planning policy, annual neonatal quantity is being risen rapidly.Folic acid is in human body cell
Very important role is play in proliferation and growth course.For physically well developed adult, these processes are not violent,
And for pregnant woman, in abdomen, the growth and development of baby is very vigorous, be unable to do without folic acid at all.Folic acid (Folic acid) is also known as
Pteroylglutamic acid (Pteroylglu-tamic acid, PGA), i.e. vitamin B11.It is a kind of thermo-labile, low molecular weight water-soluble
Property vitamin.It is made of talk endlessly pyridine core, aminobenzoic acid, glutamic acid, and human body cannot synthesize, it is necessary to take the photograph in driven plant food
It takes.The demand of general normal person's folic acid is 200~400 μ g/d, the World Health Organization suggest it is adult be at least 200 μ g/d, it is pregnant
Woman and breast milk are 400 μ g/d, and the supply amount of diet can only be an utterly inadequate amount.
There is research data to show that folic acid deficiency will lead to fetal congenital exception, especially neural tube malformation in crowd
Occur, the incidence of other birth defects can also be caused to rise, such as congenital heart disease, harelip and Tang Shi comprehensive
Sign etc., and can make embryo that serious Poly-monstrosity occur, cause embryo in mesoderm growing early stage death, in addition, folic acid deficiency can also draw
Play the generation of the Disadvantage pregnancies such as premature labor, miscarriage.And pregnancy reaction when early pregnancy, in it is pregnant when fetal weight increase can all influence to digest
Road function reduces folic acid intake；Estrogen level increases, accelerates purine metabolism when pregnant, and increases folic acid consumption.It is various
Factor makes pregnant woman that the danger of trophism folic acid deficiency very likely occur.On the other hand, for the woman of Long-term Oral contraceptive
Female, hormone in vivo is in a long time still in higher level after pregnancy, so that it is low to be easier to occur blood folate level in the pregnancy period,
Folic acid nutrition situation receives serious damage.Therefore folic acid supplementary behavior is the indispensability for breeding two tires.Before and after intended conception daily
Containing 400 μ g foliamins, it is possible to reduce a variety of newborn teratogenesis including neural tube malformation occur.Folic acid meets light, thermoae fragile
Bad, loss late is up to 80% in food reserves, process, and the absorptivity of folic acid is 70% in food, and bioavailability is only
The 1/2 ~ 2/3 of oral foliamin.Most natural folic acid are all more glutamic acid forms, and the folic acid for participating in metabolism need to be single paddy ammonia
Sour form.Therefore, the bioavilability of the more natural folic acid of artificial synthesized foliamin is more preferably.
Vitamin E also known as tocopherol are a kind of effective antioxidants, have the function of that miscarriage prevention is prevented miscarriage, and can prevent to flow
It produces, premature labor, promotes the growth and development of fetus.If pregnant woman's vitamin E deficiency can lead to muscular atrophy, abnormal development of fetus etc. no
Good consequence.Vitamin E also helps the immune system kept fit, and can promote human metabolism, enhances body endurance.
It currently, there are many type of preparation containing folic acid in the market, but is usually a variety of containing multivitamin and calcium iron etc.
The preparation of nutrient, or the preparation containing large dosage of folic acid.The folic acid of this large dosage is not suitable for pregnant woman to prevent mind
Generation through pipe deformity.The present invention is developed one kind and had not only been contained small dosage of folic acid but also contained by research, selected function related vitamin
The health food of vitamin E provides a kind of nutrient selection for the growth and healthy development of pregnant women fetus more, is to existing
Vitamin products significantly improve.
Summary of the invention
The purpose of the present invention is to provide a kind of auxiliary to promote pregnant woman's pregnancy period fetal growth and the combination of healthy development vitamin
Object health food, is composed of folic acid and vitamin E.It is a further object to provide this vitamin combinations
Preparation method.
To achieve the goals above, the invention adopts the following technical scheme:
It is a kind of for Supplement of folic acid and the vitamin combination health food of vitamin E, consist of the following compositions:
(1) vitamin E
(2) folic acid
(3) auxiliary material.
In above-mentioned health food, every (piece) content containing vitamin E is 5~150mg；Folic acid is 100~400 μ g.
Preferably, every (piece) is 20~30mg containing content of vitamin E, and the folate content is 200-300 μ g.
In the present invention, the pharmaceutic adjuvant can by a kind of in filler, disintegrating agent, corrigent, lubricant and adhesive or
It is several to be composed.
Filler of the present invention can select mannitol, sorbierite, four butanol, trehalose, lactose, sucrose etc. various
On the various preparation books such as the water-soluble filler and microcrystalline cellulose mentioned on preparation book, dextrin, starch, calcium sulfate, calcium phosphate
The water-insoluble filler mentioned.Filler can be used simultaneously a kind or a kind or more.
Disintegrating agent of the present invention can select low-substituted hydroxypropyl cellulose, crospovidone, microcrystalline cellulose, friendship
Join sodium carboxymethylcellulose, sodium carboxymethyl starch, NaSO4·10H2O, agar, starch and its derivative are handled, further includes various
That mentions on preparation book has the disintegrating agent of calving disaggregation.Disintegrating agent can be used simultaneously a kind or a kind or more.
Corrigent of the present invention includes stevioside, aspartame, alpha-lactose, maltose, saccharin sodium, protein sugar, sugarcane
Sugar, menthol etc. be natural or artificial sweetener and its various preparation books on mention for covering the addition of the adverse drug sense of taste
Agent.Corrigent can be used simultaneously a kind or a kind or more.
Lubricant of the present invention can select that mentions on talcum powder, magnesium stearate and its kind preparation book can play profit
The lubricant of sliding effect.Lubricant can be used simultaneously a kind or a kind or more.
Adhesive of the present invention can select methylcellulose, polyvinylpyrrolidone and its various preparation books above to mention
To the adhesive that can play adhesive effect.Adhesive can be used simultaneously a kind or a kind or more.Adhesive can use ethyl alcohol or water
It is made after solution for softwood processed.
Preparation method:
(1), folic acid, vitamin E and pharmaceutic adjuvant are sieved for subsequent use respectively；
(2), folic acid, vitamin E, pharmaceutic adjuvant obtained by (1) are weighed respectively by recipe quantity, places and is uniformly mixed in mixing machine；
(3), add suitable amount of adhesive that softwood is made in mixture obtained by (2), pelletize, dry, whole grain；
(4), particle obtained by (3) is added into moderate lubrication agent, it is encapsulated, capsule is made；
(5), by granulation obtained by (3), tablet is made.
The utility model has the advantages that
The nutrient prime replenisher of every (piece) containing 100~400 μ g of folic acid, 5~150mg of vitamin E is made in the present invention, is met
Daily recommended amounts in Chinese " vitamin, mineral types and dosage ".Therefore the present invention can provide reasonably for folic acid deficiency crowd
Nutritional supplementation.
Embodiments of the present invention are further described below with reference to embodiment, listed active vitamin in embodiment
Amount is as active ingredients.
Specific embodiment:
Embodiment 1:
The vitamin combination health food for being used for Supplement of folic acid and vitamin E of the present embodiment, prescription are as follows:
Prescription:
Folic acid 0.2g
Vitamin E 20g
Dextrin 235g
Pregelatinized starch 175g
PVP K30 10g
Carboxyrnethyl starch sodium 10g
Magnesium stearate 2.5g
Milk flavour 1.5g
Sucralose 0.75g
50% ethanol solution is appropriate
It is coated pre-mixing agent 15g
It is made 1000
Preparation method:
PVP K30 is taken, prepares composite adhesives with 50% ethanol solution.Folic acid, vitamin E, Sucralose, pregelatinated are formed sediment
Powder, milk flavour, carboxyrnethyl starch sodium, dextrin cross 80 meshes respectively, weigh by formula rate, set and mix 10~15 points in mixing machine
Clock.Prepared adhesive softwood is added, pelletizes in granulator, magnesium stearate is added in 55 DEG C of dry 2h, 24 mesh sieves
Mixing, tabletting.Coating pre-mixing agent is configured to solution, plain piece coating obtains the tablet of health food of the present invention.
Embodiment 2:
The vitamin combination health food for being used for Supplement of folic acid and vitamin E of the present embodiment, prescription are as follows:
Prescription:
Folic acid 0.3g
Vitamin E 30g
Dextrin 40 g
5% starch slurry is appropriate
It is made 1000
Preparation method:
Folic acid, vitamin E and dextrin are crossed into 80 meshes respectively, folic acid, vitamin E and dextrin is weighed by formula rate, sets mixing
It is mixed 10~15 minutes in machine, adds 5% starch slurry softwood processed in right amount, pelletize in granulator.Dry at 55 DEG C, 16 meshes are whole
Grain examines gained granule filling capsule, packaging to get.
Embodiment 3:
The vitamin combination health food for being used for Supplement of folic acid and vitamin E of the present embodiment, prescription are as follows:
Folic acid 0.2g
Vitamin E 20g
Microcrystalline cellulose 40g
5% polyvinylpyrrolidone is appropriate
It is made 1000
Preparation method:
Folic acid, vitamin E and microcrystalline cellulose are crossed into 80 meshes respectively, weigh folic acid by formula rate, vitamin E and crystallite are fine
Dimension element, sets in mixing machine and mixes 10~15 minutes, add 5% polyvinylpyrrolidone softwood processed in right amount, pelletize in granulator.55
Dry, 16 mesh sieves at DEG C, tabletting are examined, packaging to get.
Claims (10)
1. a kind of vitamin combination health food, it is characterised in that: acceptable including healthcare active and health food
Pharmaceutic adjuvant, the healthcare active is by small dosage of folic acid and vitamin E.
2. health food according to claim 1, it is characterised in that: in every or every, the content of vitamin E is 5
~150mg, the folate content are 100~400 μ g.
3. health food according to claim 2, it is characterised in that: in every or every, the content of vitamin E is 20
~30mg, the folate content are 200-300 μ g.
4. health food according to claim 1, it is characterised in that: wherein pharmaceutic adjuvant be selected from filler, disintegrating agent,
It is one or more kinds of in corrigent, lubricant and adhesive.
5. pharmaceutic adjuvant according to claim 4, it is characterised in that: the filler selects water-soluble filler and water
One of insoluble bulking agent or more than one, the water-soluble filler be selected from mannitol, sorbierite, four butanol, sea
One or more of algae sugar, lactose and sucrose, the water-insoluble filler is selected from microcrystalline cellulose, dextrin, starch, sulphur
One of sour calcium and calcium phosphate or more than one.
6. pharmaceutic adjuvant according to claim 4, it is characterised in that: the disintegrating agent selects low substituted hydroxy-propyl fiber
Element, crospovidone, microcrystalline cellulose, croscarmellose sodium, sodium carboxymethyl starch, NaSO4·10H2O, fine jade is handled
One of rouge, starch and its derivative or more than one.
7. pharmaceutic adjuvant according to claim 4, it is characterised in that: the corrigent selects sweetener and for covering
One of additive of the adverse drug sense of taste or more than one, the sweetener be stevioside, aspartame, alpha-lactose,
One of maltose, saccharin sodium, protein sugar, sucrose and menthol or more than one.
8. pharmaceutic adjuvant according to claim 4, it is characterised in that: the lubricant selects talcum powder, magnesium stearate
One of or more than one.
9. pharmaceutic adjuvant according to claim 4, it is characterised in that: the adhesive selects methylcellulose, poly- second
One of alkene pyrrolidone or more than one, adhesive solution can be made with ethyl alcohol or water after for softwood processed.
10. the preparation method of vitamin combination health food as described in any one of claims 1-9, it is characterised in that:
Preparation method is that folic acid, vitamin E and pharmaceutic adjuvant are sieved respectively, places and uniformly mixes in mixing machine, adds appropriate bonding
Softwood is made in agent, pelletizes, dry, and capsule or tablet is made by conventional method in pharmacy in whole grain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810127492.9A CN110122879A (en) | 2018-02-08 | 2018-02-08 | It is a kind of for Supplement of folic acid and the vitamin combination health food of vitamin E and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810127492.9A CN110122879A (en) | 2018-02-08 | 2018-02-08 | It is a kind of for Supplement of folic acid and the vitamin combination health food of vitamin E and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050043312A1 (en) * | 2003-07-25 | 2005-02-24 | Shea Thomas B. | Formulations for reducing neuronal degeneration |
| CN101120923A (en) * | 2006-08-07 | 2008-02-13 | 曾昭斌 | Vitamin and mineral nutrient complementing granule or tablet for children and teen-agers, and preparation method thereof |
| CN101176734A (en) * | 2006-11-10 | 2008-05-14 | 江西省药物研究所 | Nutrients replenisher for replenishing folic acid and vitamin B12 and preparation method thereof |
| CN106901378A (en) * | 2017-03-10 | 2017-06-30 | 深圳奥萨医疗有限公司 | A kind of health food suitable for women |
-
2018
- 2018-02-08 CN CN201810127492.9A patent/CN110122879A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050043312A1 (en) * | 2003-07-25 | 2005-02-24 | Shea Thomas B. | Formulations for reducing neuronal degeneration |
| CN101120923A (en) * | 2006-08-07 | 2008-02-13 | 曾昭斌 | Vitamin and mineral nutrient complementing granule or tablet for children and teen-agers, and preparation method thereof |
| CN101176734A (en) * | 2006-11-10 | 2008-05-14 | 江西省药物研究所 | Nutrients replenisher for replenishing folic acid and vitamin B12 and preparation method thereof |
| CN106901378A (en) * | 2017-03-10 | 2017-06-30 | 深圳奥萨医疗有限公司 | A kind of health food suitable for women |
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