CN101120923A - Vitamin and mineral nutrient complementing granule or tablet for children and teen-agers, and preparation method thereof - Google Patents

Vitamin and mineral nutrient complementing granule or tablet for children and teen-agers, and preparation method thereof Download PDF

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Publication number
CN101120923A
CN101120923A CNA2006102007833A CN200610200783A CN101120923A CN 101120923 A CN101120923 A CN 101120923A CN A2006102007833 A CNA2006102007833 A CN A2006102007833A CN 200610200783 A CN200610200783 A CN 200610200783A CN 101120923 A CN101120923 A CN 101120923A
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vitamin
adjuvant
high pressure
starch
sucrose
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曾昭斌
丁武孝
朱靖华
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Abstract

The present invention is a vitamin and microelement nutrition supplement particle or tablet for children and teenagers, by using one kind reversal kinds of the vitamin, the mineral as the raw materials preparation. The present invention is characterized in that the production comprises a bubble produced by the neutral gas; when the children and teenagers take the supplement, the bubble can release, and therefore effect of minimal bursting can occur in the mouth. The present invention also relates to the preparation method for the vitamin and microelement nutrition supplement of young children.

Description

A kind of child and teenager vitamin, mineral nutrient complementing granule or tablet and preparation method thereof
Technical field
The present invention is that a kind of with in vitamin, the mineral one or more are that the child of feedstock production and teenager vitamin, micro-element nutrition are replenished granule or tablet, is characterized in containing in the product particle micro-bubble that high pressure neutral gas forms.As the child, when teenager is taken this preparation, bubble discharges, and promotes granule and produce the effect of small explosion in mouth, increases the interest of taking.The invention still further relates to the preparation method of this juvenile's vitamin and micro-element nutrition supplement.
Background technology
Child's normal growth is grown with rational nutrition very confidential relation.Add up according to interrelated data, investigate from the Most of children diet nutritional, scarcely there is the shortage of protein and heat energy in the child nutrition of China at present, it is the deficiency of vitamin and some mineral, and these materials are to keep the indispensable element of human life, though human body is few to the requirement of this type of material, it is then most important to growth of human body normal growth and adjusting physiological function.If be deficient in vitamin in the food, mineral, not only influence upgrowth and development of children, and cause the morbid state of various vitamin of child and mineral deficiency.Therefore, try every possible means to be replenished, optimal way is the rational allocation diet, makes it can reach each age child's meals pay standard.In the real life,, be difficult to accomplish balanced diet, can cause that more or less some vitamin is under-supply owing to be subjected to the influence of factors such as provand, food processing, cooking method, dietary habit; In addition, present recommended dietary allowance is for satisfying the child nutrition needs, preventing the nutrient deficiency disease to formulate, in order to promote children's health ground growth promoter, therefore only this is not enough, is preferably on the basis of daily meals and suitably replenishes some vitamin, mineral.At present, the vitamin, the mineral nutrient supplement list marketing that have had a lot of special children of confession and teenager to take, the Themgran Junior of releasing as Shanghai Shi Guibao company, the growth of Hainan Yangshengtang Pharmaceutical Co., Ltd's listing are happy, the Centrum Junior of Hui Shi hundred palace Pharmaceuticaies etc., these kinds are on the basis of adult's vitamin, mineral nutrient supplement, according to Chinese child's dietary habit and nutrition present situation, be 2~14 years old designed for children, the high-quality compound vitamin of development, mineral nutrient supplement specially.The formulation of its each composition, each content all is the actual needs based on Chinese child, the part of vitamin, mineral Deficiency of Intake in the energy reasonable supplement China child diet.The favor that this colony of child is begged in some product exactissima diligentia simultaneously, by research to aspects such as child psychology, a lot of homework have all been done at aspects such as the taste of product, figure of tablet, name, packing, terminals, as in product, adding cocoa powder, like the chocolate eat to what product was done as the child, or add the fruity regulator, make product have the taste of fruit.On figure of tablet, changed the round or disciform normality of general medicine, and adopted shape of various lovely toys etc.Yet this colony of child is as the end user of product, what they often were concerned about is joyful, not to be concerned about very much problems such as nutrition, they like having fraicheur things, can constantly accept new things, will fade from memory gradually losing fraicheur things, this colony of child is that the phenomenon of " being inconstant or irresolute " is comparatively obvious, and vitamin, mineral nutrient supplement must be taken for a long time, and this just can cause being sick of of child inevitably, influences the effect of product.
Summary of the invention
The present invention is that a kind of with in vitamin, the mineral one or more are vitamin, mineral nutrient complementing granule or the tablet of feedstock production; contain the micro-bubble that high pressure neutral gas forms in the granule of this vitamin, mineral nutrient supplement; described bubble can produce small explosion effect in the mouth; give full play to child's curiosity; make child prefer taking these supplement; improve juvenile's the compliance of taking, thereby guaranteed that child takes this vitamin, mineral nutrient supplement for a long time.The vitamin of being chatted, mineral can be vitamin A, vitamin B 1, vitamin B 2, vitamin B 6, vitamin B 12, vitamin C, vitamin D, vitamin E, vitamin K 1, in the folic acid, biotin, pantothenic acid, nicotiamide, phosphorus, potassium, magnesium, ferrum, copper, calcium, manganese, iodine, chromium, zinc, selenium, molybdenum, nickel, stannum, vanadium, silicon one or more.This supplementary can be used as health product, food or medicine.
In order to reach above-mentioned small explosion effect, the inventor screens the adjuvant that meets medicinal requirements, and preferred diluent, sucrose, starch, gelatin or arabic gum prepare and contain the neutral gas solid adjuvant material, and have obtained suitable consumption proportion.The diluent of being chatted can be one or more of cellulose families such as saccharide such as lactose, xylitol, glucose, lactitol, maltose alcohol, fructose, dextrinose, glucosan, sorbitol and microcrystalline Cellulose pharmaceutic adjuvant commonly used.
The ratio of above-mentioned diluent, sucrose, starch, gelatin or arabic gum is:
Diluent 20~100%
Sucrose 0~50%
Starch 0~50%
Gelatin or arabic gum 0~30%
More than be weight ratio
The ratio of preferred diluent, sucrose, starch, gelatin or arabic gum is:
Diluent 20~60%
Sucrose 20~40%
Starch 20~40%
Gelatin or arabic gum 5~20%
More than be weight ratio
The invention provides the method that a kind of preparation contains the neutral gas granules of accessories, this method is that diluent, sucrose, starch, gelatin or arabic gum are placed autoclave by the mixture of said ratio, evenly mixed, be dissolved in suitable quantity of water (water content be mixture quality 25%), form slowly to be heated to just after the dense auxiliary material liquid and seethe with excitement, keep the boiling liquid temp about the solution boiling point and maintenance boil to water content and reduce to 2% when following, can add this moment such as pigment and flavoring agent etc., to regulate the color and the taste of adjuvant, make it be more suitable for child's hobby.Add the back that finishes and feed pressure in 30~50 atmospheric neutral gases at once, these neutral gases can be one or more in oxygen, air, carbon dioxide, the nitrogen, preferred 40~50 atmospheric neutral carbon dioxides, the speed of changeing with per minute 300~500 stirred 5~10 minutes, fully mix dense auxiliary material liquid and neutral gas, make the neutral gas bubble diameter that contains in the dense auxiliary material liquid reduce to quite little stage.For after stirring end, reduce about neutral gas pressure to 20~30 atmospheric pressure of reactor suddenly, make to enter the bubble that particle diameter is big in the dense auxiliary material liquid and overflow, and the bubble of other required sizes is still stayed in the dense auxiliary material liquid, so that the neutral bubble in the dense auxiliary material liquid reaches the diameter of expectation.In the reactor wall, feed 10~20 ℃ cold water cooling adjuvant when reducing pressure, treat that adjuvant cools off the fritter that lumps into multiple size, grind the adjuvant fritter with medium-speed pulverizer, the gained granule is crossed 80 mesh sieves, remove little granule with sieve, keep the granule that can cross 20 mesh sieves, bigger granules of accessories continues to join the agitating device gentle agitation, the pharmacy commonly used adjuvant of repetitive operation to obtain diameter at 80 orders~20 purpose adjuvants, promptly to get to contain neutral gases at high pressure.
The invention provides the method that another kind of preparation contains neutral gases at high pressure granules of accessories, this method is to use as Figure of description mesohigh sprayer unit and prepares the adjuvant that contains high pressure neutral gas, operational approach is 20~30 atmospheric pressure for feeding 10~20 ℃ cold water cooled containers and keep the middle pressure of high pressure resistant double container (5) in high pressure resistant double container (5) wall, then diluent, sucrose, starch, gelatin or arabic gum are placed high pressure stirred tank (8) by the mixture of said ratio, evenly mixed, heating makes dense auxiliary material liquid.These dense auxiliary material liquid are input to sample bottle (3), with high pressure neutral gas ejection, promptly get the pharmacy that contain neutral gas commonly used adjuvant after condensing into solid through spray gun (1).
The adjuvant of method for preparing can be prepared into oral granular formulation, chewable tablet or the oral cavity disintegration tablet of vitamin, mineral by conventional method known in the art, when oral, the bubble release gas that breaks, small bubble discharges, and produces the effect of small explosion in mouth.Simultaneously also can add the fruity regulator, produce the product that is fit to child's taste, product can also be made the shape of various lovely toys, to satisfy the many-sided demand of child.
Description of drawings
Figure one is the structural representation that preparation contains the high pressure sprays fog equipment of high pressure neutral gas.
Among the figure: (1) is the high-pressure fog spray gun, (2) be the gun controls switch, (3) be sample bottle, (5) be high pressure resistant double container, can feed cold water cooling entire container in the wall, (4) be the bi-directional compression air line, switch controls Compressed Gas on the pipeline is only carried or is only carried to withstand voltage double container (5) to spray gun (1), (6) be gas compressor, can feed high pressure neutral gas in entire container, (7) are pressure control valve, can keep constant pressure in the container, (8) be the high pressure stirred tank, (9) are the conveyance conduit of belt switch.Sample bottle (3), compressed air hose pipeline joint and spray gun (1) constitute one, and link to each other with gas compressor by compressed air piping 4.Whole device constitutes an airtight pressure vessel.
The specific embodiment
The following examples can help those skilled in the art more fully to understand the present invention, but do not limit the present invention in any way.
Embodiment 1: contain the preparation of the lactose granules of accessories of neutral carbon dioxide
1,3kg lactose, 2kg sucrose are dropped in the autoclave, add 1 premium on currency simultaneously;
2, slowly increase and about temperature of reaction kettle to 120 ℃ lactose is slowly dissolved to be liquid state, to keep the temperature transpiring moisture to make final water content 2%;
3, feed 50 atmospheric neutral carbon dioxides, the speed of changeing with per minute 400 stirs the lactose slurry simultaneously;
4, stop after 7 minutes stirring, reducing autoclave pressure is 25 atmospheric pressure, feeds 15 ℃ of cold water cooling lactose slurries in the reactor wall;
5, treat that the fritter of multiple size is lumpd in lactose cooling after, pour out lactose, with medium-speed pulverizer the lactose fritter is worn into granule, collect and can and can not pass through the lactose of 80 mesh sieves by 20 mesh sieves, promptly get the lactose that contains neutral carbon dioxide.
Embodiment 2: contain lactose, sucrose and the particulate preparation of starch mixed accessories of neutral carbon dioxide
1,3kg lactose, 1kg sucrose and 1kg corn another name for Sichuan Province starch are dropped in the autoclave, add 1.5 premium on currency simultaneously;
2, slowly increase and about temperature of reaction kettle to 120 ℃ pressed powder is slowly dissolved to be liquid state, to keep the temperature transpiring moisture to make final water content 3%;
3, feed 50 atmospheric neutral carbon dioxides, the speed of changeing with per minute 400 stirs the lactose slurry simultaneously;
4, stop after 7 minutes stirring, reducing autoclave pressure is 25 atmospheric pressure, feeds 15 ℃ of cold water cooling lactose slurries in the reactor wall;
5, treat that the fritter of multiple size is lumpd in syrup cooling after, pour out, with medium-speed pulverizer fritter is worn into granule, collect and can and can not pass through the granule of 80 mesh sieves by 20 mesh sieves, promptly get lactose, sucrose and the starch hybrid particles of neutral carbon dioxide.
Embodiment 3: contain lactose, sucrose, gelatin and the particulate preparation of starch mixed accessories of neutral carbon dioxide, adding gelatin is in order to increase the particulate crushing resistance of gained, to remain on particulate integrity in the tabletting process
1,2kg lactose, 1kg sucrose, 1kg gelatin and 1kg corn another name for Sichuan Province starch are dropped in the autoclave, add 3 premium on currency simultaneously;
2, slowly increase and about temperature of reaction kettle to 120 ℃ pressed powder is slowly dissolved to be liquid state, to keep the temperature transpiring moisture to make final water content 3%;
3, feed 50 atmospheric neutral carbon dioxides, the speed of changeing with per minute 400 stirs the lactose slurry simultaneously;
4, stop after 8 minutes stirring, reducing autoclave pressure is 25 atmospheric pressure, feeds 15 ℃ of cold water cooling lactose slurries in the reactor wall;
5, treat that the fritter of multiple size is lumpd in syrup cooling after, pour out, with medium-speed pulverizer fritter is worn into granule, collect and can and can not pass through the granule of 80 mesh sieves by 20 mesh sieves, promptly get lactose, sucrose and the starch hybrid particles of neutral carbon dioxide.
Embodiment 4: by contain lactose, sucrose, gelatin and the starch mixed accessories granule of neutral gases at high pressure as the high pressure sprays fog equipment preparation of Figure of description
1, in high pressure resistant double container (5) wall, feeds 10~20 ℃ cold water cooled containers.
2, using gases compressor (6) is compressed into 45 atmospheric gases with neutral gas, regulate the switch of bi-directional compression air line (4), the high pressure neutral gas of generation is only carried in high pressure resistant double container (5), and adjusting pressure control valve (7), it is just opened greater than 30 atmospheric pressure at high pressure resistant double container pressure, emit gas, pressure remains at 30 atmospheric pressure in the high pressure resistant double container (5) to keep.
3, treat that pressure reaches 30 atmospheric pressure in the high pressure resistant double container after, regulate the switch of bi-directional compression air line (4) at once, make the only conveying to spray gun (1) in of high pressure neutral gas of generation.
4, use diluent, sucrose, starch, gelatin or arabic gum are placed high pressure stirred tank (8) as Figure of description mesohigh sprayer unit by the mixture of said ratio, evenly mixed, be dissolved in suitable quantity of water (water content be mixture quality 25%), form slowly to be heated to just after the dense auxiliary material liquid and seethe with excitement, keep the boiling liquid temp about the solution boiling point and maintenance boil to water content and reduce to 2% when following, can add this moment such as pigment and flavoring agent etc., to regulate the color and the taste of adjuvant, make it be more suitable for child's hobby.
5, add the back that finishes and feed pressure in 30~50 atmospheric neutral gases at once, these neutral gases can be one or more in oxygen, air, carbon dioxide, the nitrogen, preferred 40~50 atmospheric neutral carbon dioxides, the speed of changeing with per minute 300~500 stirred 5~10 minutes, fully mix dense auxiliary material liquid and neutral gas, make the neutral gas bubble diameter that contains in the dense auxiliary material liquid reduce to quite little stage.
6, after stir finishing, open the switch of conveyance conduit (9), utilize pressure that all dense auxiliary material liquid are transported in the sample bottle (3), treat dense auxiliary material liquid carry finish after, the switch of cutting out conveyance conduit (9) refluxes to prevent dense auxiliary material liquid at once.
7, open Switch of spray pistol (2), make the dense auxiliary material liquid in the sample bottle (3) mix 50 atmospheric neutral gases at high pressure ejections, obtain containing the adjuvant of neutral gases at high pressure after condensing.
Embodiment 5: the preparation of vitamin C granules agent
Prescription: vitamin C (fine powder or superfine little crystallization) 100g
Tartaric acid 1g
50% ethanol is an amount of
Magnesium stearate 1.5g
Granule 900g as embodiment 1 preparation
Make 1000 bags
Method for making: vitamin C is placed the electronic mixer of rustless steel, in addition tartaric acid is dissolved in 50% alcohol, once joins in the ascorbic mixed-powder mix homogeneously, make soft material, once make the wet grain of 20~40 orders by 20 order nylon mesh, put drying in the drying baker, temperature is no more than 60 ℃ during beginning, temperature can rise to below 70 ℃ when dry nearly, quickening drying, but temperature is unsuitable too high, in order to avoid variable color.Dry granular adds as granule, the magnesium stearate of embodiment 1 preparation and mixes and stirs by 20 mesh sieves, packs promptly, and every pouch net content is about 1g.The child, when teenager is taken, granule is kept in the mouth, discharge neutral carbon dioxide, produce the effect of small explosion.
Embodiment 6: the preparation of vitamin C oral disintegration tablet
Prescription: vitamin C (fine powder or superfine little crystallization) 100g
Crospolyvinylpyrrolidone 400g
Mannitol 100g
Magnesium stearate 7.0g
Granule 200g as embodiment 2 preparations
Make 1000
Method for making: with vitamin C, crospolyvinylpyrrolidone, mannitol mixing, cross 80 mesh sieves, add granule and magnesium stearate then, behind the mix homogeneously, adopt direct compression process to prepare sheet and heavily be the tablet of 0.8g as embodiment 2 preparations.The gained tablet complete bright and clean, color and luster is even.The gained tablet need not water delivery service, and rapidly disintegrate and dissolving produces the effect of small explosion in the oral cavity.
Embodiment 7: the preparation of juvenile's vitamin A chewable tablet
The retinyl acetate dry powder (325,000i.u./g) 350g
Mannitol 100g
Granule 200g as embodiment 3 preparations
Polyvinylpyrrolidone 350g
Magnesium stearate 5g
Micropowder silica gel 200 3g
Make 1000
Method for making: all the components of mixing recipe quantity, direct compression can get the vitamin A chewable tablet.Gained tablet weight 1g, the surface complete bright and clean, color and luster is even.When the gained tablet is chewed,, produce the effect of small explosion at dissolved in oral cavity in mouth.
Embodiment 8: the preparation of juvenile's multivitamin chewable tablet
Vitamin A (500,000i.u./g) 7.0g
Thiamine mononitrate 1.2g
Riboflavin sodium phosphate 1.2g
Nicotiamide 20.0g
Vitamin B 61.8g
Vitamin B 126.5g
Vitamin C 60.0g
Vitamin D 3(100,000 i.u./g) 5.0g
Vitamin E 31.0g
Sorbitol 100.0g
Sucrose 50.0g
Granule 250g as embodiment 3 preparations
Polyvinylpyrrolidone 450g
Micropowder silica gel 200 1.0g
Flavoring orange essence powder 30.0g
Raspberry flavour conc.na powder 6.0g
Herba Passiflorae Caeruleae essence powder 3.0g
Sodium cyclamate 2.0g
Make 1000
Method for making: mixing all the components, direct compression are promptly.The gained tablet surface complete bright and clean, color and luster is even.When the gained tablet was chewed in mouth, adjuvant produced the effect of small explosion at dissolved in oral cavity.
Embodiment 9: the particulate preparation of juvenile's multivitamin
Prescription: vitamin A 5,000,000 units
Vitamin D 400,000 units
Vitamin E 30,000 units
Vitamin C 60 grams
Folic acid 0.4 gram
Vitamin B 11.5 gram
Vitamin B 21.7 gram
Nicotiamide 20 grams
Vitamin B 62 grams
Vitamin B 126 milligrams
Starch 100g
5% hypromellose (HPMC) is an amount of
Micropowder silica gel 1.5g
Adjuvant 300g as embodiment 3 preparations
Make 1000 bags
Method for making: get all principal agent porphyrizes of recipe quantity, cross 100 mesh sieves, starch is crossed 80 mesh sieves, and is standby.Get HPMC, add water and make 5%HPMC solution, as binding agent.All principal agents of recipe quantity and starch mixing add 5%HPMC solution, cross 30 mesh sieves and granulate 60 ℃ of dryings, 30 order granulate.The auxiliary materials and mixing that dried granule added 100 purpose micropowder silica gels and prepared as embodiment 3, pack promptly.The child, when teenager is taken, granule is kept in the mouth, when lactose dissolves, discharge neutral carbon dioxide, produce the effect of small explosion.
Embodiment 10: the particulate preparation of juvenile's multivitamin
Prescription: folic acid 400mg, nicotiamide 20g, vitamin A 5,000,000 units, vitamin B 11.5g, vitamin B 126mg, vitamin B 21.7g, vitamin B 62g, vitamin C 60g, vitamin D 400,000 units, vitamin E 30,000 units, starch 100g, 5% hypromellose (HPMC) is an amount of, and micropowder silica gel 1.5g is as the adjuvant 300g of embodiment 3 preparations.
Method for making is made 1000 bags with embodiment 9.

Claims (10)

1. one kind is that the child of feedstock production and teenager vitamin, micro-element nutrition are replenished granule or tablet with in vitamin, the mineral one or more, it is characterized in that containing in the product particle micro-bubble that high pressure neutral gas forms.As the child, when teenager is taken this preparation, bubble discharges, and promotes granule and produce the effect of small explosion in mouth, increases the interest of taking.
2. according to the nutrient complementing granule or the tablet of claim 1, wherein the vitamin of being chatted, mineral can be one or more in vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K1, folic acid, biotin, pantothenic acid, nicotiamide, phosphorus, potassium, magnesium, ferrum, copper, calcium, manganese, iodine, chromium, zinc, selenium, molybdenum, nickel, stannum, vanadium, the silicon.
3. a pharmacy adjuvant that contains neutral gas is characterized in that containing in the adjuvant bubble that neutral gases at high pressure form.
4. pharmacy adjuvant according to claim 3 is characterized in that the solid adjuvant material that contains neutral gas that diluent, sucrose, starch, gelatin or arabic gum are prepared into.
5. pharmacy adjuvant according to claim 4, wherein the diluent of chatting can be one or more of cellulose families such as saccharide such as lactose, xylitol, glucose, lactitol, maltose alcohol, fructose, dextrinose, glucosan, sorbitol and microcrystalline Cellulose pharmaceutic adjuvant commonly used.
6. according to claim 4 described pharmacy adjuvants, wherein the ratio of diluent, sucrose, starch, gelatin or arabic gum is:
Diluent 20~100%
Sucrose 0~50%
Starch 0~50%
Gelatin or arabic gum 0~30%
More than be weight ratio.
7. according to claim 4 described pharmacy adjuvants, wherein the ratio of diluent, sucrose, starch, gelatin or arabic gum is:
Diluent 20~60%
Sucrose 20~40%
Starch 20~40%
Gelatin or arabic gum 5~20%
More than be weight ratio.
8. according to the preparation method of the adjuvant of claim 4, it is characterized in that the mixture of diluent, sucrose, starch, gelatin or arabic gum proportioning is placed autoclave, evenly mixed, heating makes dense auxiliary material liquid.Feed pressure in 30~50 atmospheric neutral gases, these neutral gases can be one or more in oxygen, air, carbon dioxide, the nitrogen, preferred 40~50 atmospheric neutral carbon dioxides, fully mix dense auxiliary material liquid and neutral gas, after stirring end, reduce suddenly about neutral gas pressure to 20~30 atmospheric pressure of reactor.In the reactor wall, feed cold water cooling adjuvant when reducing pressure, treat that adjuvant cools off the fritter that lumps into multiple size, grind the adjuvant fritter, obtain diameter, promptly get the pharmacy that contains neutral gases at high pressure adjuvant commonly used at 80 orders~20 purpose adjuvants with medium-speed pulverizer.
9. according to the preparation method of the adjuvant of claim 4, it is characterized in that using the high pressure sprays fog equipment preparation to contain the adjuvant of high pressure neutral gas, it is characterized by in the wall of high pressure resistant double container (5) and to feed the cold water cooled containers and to keep that pressure is 20~30 atmospheric pressure in the high pressure resistant double container (5), mixture with diluent, sucrose, starch, gelatin or arabic gum proportioning places high pressure stirred tank (8) then, evenly mixed, heating makes dense auxiliary material liquid.These dense auxiliary material liquid are input in the sample bottle (3), with high pressure neutral gas ejection, promptly get the pharmacy that contain neutral gas commonly used adjuvant after condensing into solid through spray gun (1).
10. according to the application of the adjuvant of claim 4, it is characterized in that containing oral granule, chewable tablet or the oral cavity disintegration tablet of small high pressure bubble by known conventional method preparation.
CNA2006102007833A 2006-08-07 2006-08-07 Vitamin and mineral nutrient complementing granule or tablet for children and teen-agers, and preparation method thereof Pending CN101120923A (en)

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101869295A (en) * 2010-05-24 2010-10-27 北京世纪维他生物技术有限公司 Production method of nutrient premix used for foods
CN103431391A (en) * 2013-08-28 2013-12-11 张秀平 Comprehensive nutrition powder
CN104127435A (en) * 2014-07-21 2014-11-05 福建省力菲克药业有限公司 Vitamin mineral sublingual lozenge and a preparation method thereof
CN106361588A (en) * 2016-10-27 2017-02-01 陆腾蛟 Tooth cleaning product and production device and process
CN106491640A (en) * 2017-01-11 2017-03-15 江苏艾兰得营养品有限公司 A kind of Vc zincification dissolution formulation and preparation method thereof
CN110122879A (en) * 2018-02-08 2019-08-16 越洋医药开发(广州)有限公司 It is a kind of for Supplement of folic acid and the vitamin combination health food of vitamin E and preparation method thereof
CN113509445A (en) * 2021-04-07 2021-10-19 海南锦瑞制药有限公司 Voriconazole dispersible tablet and preparation method thereof
CN113729222A (en) * 2020-05-29 2021-12-03 李永川 A food or health food containing endothelium corneum Gigeriae Galli for children and its preparation method

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101869295A (en) * 2010-05-24 2010-10-27 北京世纪维他生物技术有限公司 Production method of nutrient premix used for foods
CN101869295B (en) * 2010-05-24 2012-05-02 北京世纪维他生物技术有限公司 Production method of nutrient premix used for foods
CN103431391A (en) * 2013-08-28 2013-12-11 张秀平 Comprehensive nutrition powder
CN104127435A (en) * 2014-07-21 2014-11-05 福建省力菲克药业有限公司 Vitamin mineral sublingual lozenge and a preparation method thereof
CN104127435B (en) * 2014-07-21 2017-06-20 福建省力菲克药业有限公司 A kind of vitamin and minerals sublingual lozenge and preparation method thereof
CN106361588A (en) * 2016-10-27 2017-02-01 陆腾蛟 Tooth cleaning product and production device and process
CN106491640A (en) * 2017-01-11 2017-03-15 江苏艾兰得营养品有限公司 A kind of Vc zincification dissolution formulation and preparation method thereof
CN110122879A (en) * 2018-02-08 2019-08-16 越洋医药开发(广州)有限公司 It is a kind of for Supplement of folic acid and the vitamin combination health food of vitamin E and preparation method thereof
CN113729222A (en) * 2020-05-29 2021-12-03 李永川 A food or health food containing endothelium corneum Gigeriae Galli for children and its preparation method
CN113509445A (en) * 2021-04-07 2021-10-19 海南锦瑞制药有限公司 Voriconazole dispersible tablet and preparation method thereof
CN113509445B (en) * 2021-04-07 2023-06-27 海南锦瑞制药有限公司 Voriconazole dispersible tablet and preparation method thereof

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Application publication date: 20080213