CN100512799C - Effervescence tablet containing multiplex vitamin including iron, zinc and calcium, ring shaped preparation and preparation method - Google Patents
Effervescence tablet containing multiplex vitamin including iron, zinc and calcium, ring shaped preparation and preparation method Download PDFInfo
- Publication number
- CN100512799C CN100512799C CNB2004100609497A CN200410060949A CN100512799C CN 100512799 C CN100512799 C CN 100512799C CN B2004100609497 A CNB2004100609497 A CN B2004100609497A CN 200410060949 A CN200410060949 A CN 200410060949A CN 100512799 C CN100512799 C CN 100512799C
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- China
- Prior art keywords
- vitamin
- effervescent tablet
- agent
- calcium
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 229940088594 vitamin Drugs 0.000 title claims abstract description 22
- 229930003231 vitamin Natural products 0.000 title claims abstract description 22
- 235000013343 vitamin Nutrition 0.000 title claims abstract description 22
- 239000011782 vitamin Substances 0.000 title claims abstract description 22
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims description 54
- 238000002360 preparation method Methods 0.000 title claims description 35
- 229910052742 iron Inorganic materials 0.000 title claims description 26
- 150000003722 vitamin derivatives Chemical class 0.000 title claims description 18
- 239000011575 calcium Substances 0.000 title abstract description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title description 5
- 229910052791 calcium Inorganic materials 0.000 title description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title 1
- 229910052725 zinc Inorganic materials 0.000 title 1
- 239000011701 zinc Substances 0.000 title 1
- 239000007938 effervescent tablet Substances 0.000 claims abstract description 83
- 239000011790 ferrous sulphate Substances 0.000 claims abstract description 11
- 235000003891 ferrous sulphate Nutrition 0.000 claims abstract description 11
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims abstract description 11
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims abstract description 11
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims abstract description 11
- 229960001763 zinc sulfate Drugs 0.000 claims abstract description 11
- 229910000368 zinc sulfate Inorganic materials 0.000 claims abstract description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 54
- 235000016709 nutrition Nutrition 0.000 claims description 30
- 238000002156 mixing Methods 0.000 claims description 28
- IHBCFWWEZXPPLG-UHFFFAOYSA-N [Ca].[Zn] Chemical compound [Ca].[Zn] IHBCFWWEZXPPLG-UHFFFAOYSA-N 0.000 claims description 27
- 239000002202 Polyethylene glycol Substances 0.000 claims description 26
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 26
- 229920001223 polyethylene glycol Polymers 0.000 claims description 26
- 238000002372 labelling Methods 0.000 claims description 25
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 24
- 239000011230 binding agent Substances 0.000 claims description 22
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 16
- 239000000314 lubricant Substances 0.000 claims description 15
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 14
- 230000001476 alcoholic effect Effects 0.000 claims description 14
- 125000003118 aryl group Chemical group 0.000 claims description 14
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 14
- 239000008187 granular material Substances 0.000 claims description 14
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 14
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 14
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 12
- 229930003268 Vitamin C Natural products 0.000 claims description 12
- 235000019154 vitamin C Nutrition 0.000 claims description 12
- 239000011718 vitamin C Substances 0.000 claims description 12
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 9
- 235000011090 malic acid Nutrition 0.000 claims description 9
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 claims description 8
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 8
- 239000000377 silicon dioxide Substances 0.000 claims description 8
- 235000012239 silicon dioxide Nutrition 0.000 claims description 8
- 235000002906 tartaric acid Nutrition 0.000 claims description 8
- 239000011975 tartaric acid Substances 0.000 claims description 8
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 7
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 7
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 7
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 7
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 7
- 229930003427 Vitamin E Natural products 0.000 claims description 7
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 7
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 7
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 7
- 235000013734 beta-carotene Nutrition 0.000 claims description 7
- 239000011648 beta-carotene Substances 0.000 claims description 7
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 7
- 229960002747 betacarotene Drugs 0.000 claims description 7
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 7
- 229960002079 calcium pantothenate Drugs 0.000 claims description 7
- 229960000304 folic acid Drugs 0.000 claims description 7
- 235000019152 folic acid Nutrition 0.000 claims description 7
- 239000011724 folic acid Substances 0.000 claims description 7
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 7
- 235000019359 magnesium stearate Nutrition 0.000 claims description 7
- 239000001630 malic acid Substances 0.000 claims description 7
- 229960003080 taurine Drugs 0.000 claims description 7
- 235000019155 vitamin A Nutrition 0.000 claims description 7
- 239000011719 vitamin A Substances 0.000 claims description 7
- 235000019165 vitamin E Nutrition 0.000 claims description 7
- 239000011709 vitamin E Substances 0.000 claims description 7
- 229940046009 vitamin E Drugs 0.000 claims description 7
- 229940045997 vitamin a Drugs 0.000 claims description 7
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 7
- 229960004543 anhydrous citric acid Drugs 0.000 claims description 6
- 235000015165 citric acid Nutrition 0.000 claims description 6
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 6
- 235000017550 sodium carbonate Nutrition 0.000 claims description 6
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 5
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 5
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 5
- 239000001530 fumaric acid Substances 0.000 claims description 5
- HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 claims description 5
- 239000011736 potassium bicarbonate Substances 0.000 claims description 5
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 5
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 5
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 5
- 235000011181 potassium carbonates Nutrition 0.000 claims description 5
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 5
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 5
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- 235000010216 calcium carbonate Nutrition 0.000 claims description 4
- 229960004106 citric acid Drugs 0.000 claims description 4
- 229960002598 fumaric acid Drugs 0.000 claims description 4
- 235000011087 fumaric acid Nutrition 0.000 claims description 4
- 229940099690 malic acid Drugs 0.000 claims description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 4
- 229960001367 tartaric acid Drugs 0.000 claims description 4
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 3
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 4
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 abstract 1
- 229940062672 calcium dihydrogen phosphate Drugs 0.000 abstract 1
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- 239000000686 essence Substances 0.000 description 18
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- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
An annular effervescent tablet containing Fe, Ze, Ca and vitamins for children and juveniles is prepared from ferrous sulfate, zinc sulfate, calcium dihydrogen phosphate, VC, etc, through particular technology. It has high disintegrating speed.
Description
Technical field
The present invention relates to health food effervescent tablet and preparation method thereof technical field, relate in particular to a kind of multivitamin effervescent tablet of iron content zinc calcium and annular preparation and preparation method.
Background technology
Human body every day all must be by obtaining various nutrients in the diet, but the requirement of every kind of nutrient is all had a suitable scope, and intake is crossed and lowly can be caused some disease, the too high danger that then can cause poisoning.And the kind of every kind of food institute nutrient containing all is different with quantity, people are the intakes of regulating various nutrients by balanced diet in the daily life, but the child of China and the phenomenon of teenager ubiquity monophagia usually cause in the body certain nutrient to lack and influence normal growth promoter and healthy.As lack vitamin, and can cause tooth unsound, skeleton development is slow, symptoms such as elongation deficiency; Calcium deficiency causes dysplasia; Iron deficiency causes anemia; Zinc deficiency causes intelligence unsound.The health food nutrition arrangement is various in the market, allows consumers in general be difficult to follow; Common multivitamin agent producing process falls behind, and it is inhomogeneous to cause mcg vitamin to disperse, and has influenced curative effect; Dosage form is single, and the picture that supplements the nutrients is taken medicine, and is difficult to cause child and teen-age interest, thereby has influenced replenishing of nutrition.
Effervescent tablet is to be a kind of novel form that disintegrating agent is made with the effervescent material, drop in the water and can produce a large amount of bubbles, and dissolving within a short period of time, have characteristics such as onset is rapid, bioavailability is high, easy to carry, with the characteristics of solid preparation and liquid preparation.And the oral administration effervescing sheet is specially adapted to the patient of child, old people and the solid preparation of can not swallowing.Ring segment early has application in food industry, but in health food effervescent tablet preparation field, does not appear in the newspapers as yet.The vitamins effervescent formulation is existing procucts production at home and abroad in recent years, as vitamin C effervescent tablet, but with various trace elements for example ferrum zinc calcium and vitamin make quickly disintegrated annular effervescent tablet, do not appear in the newspapers as yet.
Because of the vitamin amount that human body every day is required considerably less, for example the content of the various vitamin that must absorb every day is at several milligrams to tens milligrams, if make common vitamin effervescent tablet,, the vitamin effervescent tablet do not have solubility problem in the 100-200 ml water usually because of being dissolved in.
But human body required calcium content every day needs the hundreds of milligram approximately, and is more relatively.Relative 1000 milliliters (18 degrees centigrade time) water can dissolve 700 gram citric acids, 700 gram tartaric acid simultaneously, and the common water solublity of calcium salt is bad, and for example the dissolubility of dalcium biphosphate is/1000 milliliters of 18 grams (30 degrees centigrade time).
The disintegrate of effervescent tablet in water can not be leaned on manual the stirring and mechanical agitation, what rely on is that the carbon dioxide air source that sour agent and alkaline agent reaction discharge stirs, if therefore make calcareous effervescent tablet, bad because of calcium salt water solublity such as dalcium biphosphates, can influence the disintegration rate of whole effervescent tablet in water.When disintegration rate up to 3-5 minute, can influence the patience of consumer, its commercial value sharply descends.
More because of contained nutritional labeling in the prescription, physicochemical property has multiformity, needs to add more binding agent in preparation effervescent tablet process, could guarantee that finished product hardness is qualified, binder dosage increases a little, the disintegration rate that also can slow down, but this has also influenced the disintegration rate of effervescent tablet from another point of view.
By the custom that consumer has a drink, drink the beverage of 100-200 milliliter at every turn, therefore the solid matter that provides of every effervescent tablet will satisfy keep enough nutrition and mouthfeel in the 100-200 ml water.The monolithic weight of the vitamins that provides in the market and the effervescent tablet of replenishing the calcium reaches about 4 grams.This and the common 0.35 gram/sheet of western medicine tablet have huge difference on deal.20/pipe of leading products " Kant's dimension " the board vitamin C effervescent tablet of for example German SUNLIFE company (weight 90 grams).4 gram tablets and 0.35 gram tablet are widely different on water solublity.The disintegration rate of the composite effervescent sheet that weight ratio is bigger is slow.
If it is to improve disintegration rate that ferrum zinc calcium multivitamin is made the difficult problem that the bigger composite effervescent sheet of weight ratio must overcome.
Summary of the invention
The purpose of this invention is to provide a kind of multivitamin effervescent tablet of iron content zinc calcium and annular preparation and preparation method, more comprehensively to satisfy the needs that child and teenager daily nutrition replenish better.Annular preparation disintegrate fast wherein, commercial value is big.
Technical scheme of the present invention has following:
The multivitamin effervescent tablet of iron content zinc calcium, wherein: the composition of this effervescent tablet comprises weight proportion: some parts of nutritional labeling, sour agent 50-150 part, alkaline agent 40-120 part, binding agent 1-15 part, lubricant 1-5 part, sweeting agent 1-120 part, aromatic 0-5 part; Wherein nutritional labeling comprises: ferrous sulfate 0.1-0.4 part, zinc sulfate 0.1-0.4 part, dalcium biphosphate 8-20 part, vitamin C 0.2-0.8 part; The acid agent can be selected from one or more in citric acid, tartaric acid, malic acid, fumaric acid, anhydrous citric acid, the sodium dihydrogen citrate salt; Alkaline agent can be selected from one or more in potassium carbonate, potassium bicarbonate, sodium carbonate, sodium bicarbonate, calcium carbonate, the calcium bicarbonate; Binding agent is selected from the alcoholic solution of Polyethylene Glycol (PEG); Lubricant is selected from one or more in Polyethylene Glycol (PEG) 6000, Polyethylene Glycol (PEG) 4000, sodium lauryl sulphate, magnesium stearate, Pulvis Talci, the silicon dioxide.
The multivitamin effervescent tablet of iron content zinc calcium; wherein: the composition of this effervescent tablet also comprises weight proportion: 0.004 part of vitamin A, 0.001 part of beta-carotene, 0.001 part in folic acid; 0.015 part of calcium pantothenate; 0.3 part of taurine, vitaminB10 .005 part, 0.005 part of vitamin B2; 0.005 part of vitamin B6; 0.000015 part of vitamin B12,0.000005 part of vitamin D3,0.0375 part of vitamin E.
The multivitamin effervescent tablet of iron content zinc calcium, wherein: this effervescent tablet is annular preparation.
The multivitamin effervescent tablet of iron content zinc calcium, wherein: annular preparation comprises circular ring type, oval ring-like, polygon in ring-like any one.
The multivitamin effervescent tablet of iron content zinc calcium, wherein: polygonly ring-likely be that triangle is ring-like, ring-like, the five side ring types in four directions, hexagon are ring-like, in ring-like any one of eight side ring types, odd plots of land that can be cultivated.
The multivitamin effervescent tablet of iron content zinc calcium, wherein: the outer ring diameter of annulus is the 10-35 millimeter, interior ring diameter is the 2-8 millimeter.
The multivitamin effervescent tablet of iron content zinc calcium, wherein: the outer ring diameter of annulus is the 12-18 millimeter, interior ring diameter is the 4-8 millimeter.
The preparation method of the multivitamin effervescent tablet of iron content zinc calcium, concrete steps comprise: with the nutritional labeling mixing, get the A part; Alkaline agent, sweeting agent mixing add binding agent, cross 20 mesh sieves and granulate, and 45-50 ℃ is dried to moisture and is lower than 0.1%, and granulate is crossed the pharmacopeia sieve No. 2, the B part; 100 order pharmacopeia sieve was pulverized in the acid agent, granulated, and got the C part; C partly adds aromatic, sweeting agent, with A part, B part mixing, adding lubricant, mixing, tabletting in ring-like mould, promptly gets the effervescent tablet of annular preparation.
Sweeting agent is selected from one or more in cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, saccharin sodium (calcium), the lactose etc.; Aromatic wherein is selected from one or more among orange essence, flavoring orange essence, Herba Menthae essence or Fructus Citri Limoniae essence, the flavoring banana essence.
The selection of sweeting agent and aromatic can also be the material of other drug food administrative service division permission.Because of sweeting agent and aromatic mainly are to be used to regulate mouthfeel, not emphasis of the present invention, do not need to repeat to enumerate the kind of various sweeting agents and aromatic.
In the above-mentioned preparation method, granulating process can adopt methods such as wet granulation, dry granulation, one-step palletizing when big production.
Compare with existing conventional tablet health food, the present invention has following characteristics:
1, the various nutritional labeling proportioning equilibrium of prescription of the present invention can be satisfied the actual needs that Chinese child and teenager daily nutrition replenish;
2, adopt modern dispersion technology, make the effervescent dosage form, micro-nutrient composition is uniformly dispersed in the product, helps absorption in vivo, has improved bioavailability;
3, effervescent tablet is dropped in the water, disintegrating agent is wherein met water acid-base reaction is taken place at once, and the carbon dioxide of generation makes the rapid disintegrate of tablet become microgranule and dissolves, and forms liquid beverage, delicious taste, and the notion of elimination " medicine " when taking, the easier people of allowing accepts;
4, produce a large amount of carbon dioxide during the effervescent tablet effervescent, tablet is seethed up and down, and surrounded by bubble group, send the sound of " whistling " simultaneously, have much interest, can satisfy child and teen-age curious psychology, the easier people of allowing accepts.
5, make annular effervescent tablet, disintegrate is faster, uses more convenient.More because of contained nutritional labeling in the prescription, physicochemical property has multiformity, needs to add more binding agent in preparation effervescent tablet process, could guarantee that finished product hardness is qualified, but also therefore influence the disintegration rate of effervescent tablet simultaneously.After being made into ring segment, increased the contact surface of disintegrating agent and water, made disintegrating agent from about two aspects and water effect.Effervescent tablet is easy to rupture after being subjected to the power of both direction, thereby has increased the contact surface with water more, makes effervescent tablet disintegrate fully in the short time.The present invention's prescription is made annular effervescent tablet and common effervescent tablet respectively, and both comparing results on disintegration time are as follows:
Make effervescent powder by embodiment 9 prescriptions and technology, it is 20 millimeters that a part of solid tabletting obtains external diameter, the composite effervescent sheet of the 4 gram/sheets that weight is.Another part is tabletting in ring-like mould, and promptly obtaining weight is the composite ring effervescent tablet of 4 gram/sheets, and its outer ring diameter is 28 millimeters, and interior ring diameter is 6 millimeters.Two kinds of effervescent tablets are put into 150 milliliters of (18 degrees centigrade) water to be observed:
Configuration design is circularized, and is the characteristics of maximum of the present invention.Because annular effervescent tablet can significantly improve disintegration rate, has saved the consumption of disintegrating agent to a certain extent, thereby has simplified prescription, provides cost savings.Simultaneously, the annular compound vitamin effervescent tablet of disintegrate in two minutes even in a minute had both met national standard, can satisfy people's demand easy to use again; Need the disintegrate of 4-5 minute ability to compare with the bread and cheese effervescent tablet, the commercial value of annular effervescent tablet aspect the disintegrate convenience is higher.
Specific embodiment
Embodiment 1,
The multivitamin effervescent tablet of iron content zinc calcium, wherein: the composition of this effervescent tablet comprises weight proportion: some parts of nutritional labeling, sour agent 50-150 part, alkaline agent 40-120 part, binding agent 1-15 part, lubricant 1-5 part, sweeting agent 1-120 part, aromatic 0-5 part; Wherein nutritional labeling comprises: ferrous sulfate 0.1-0.4 part, zinc sulfate 0.1-0.4 part, dalcium biphosphate 8-20 part, vitamin C 0.2-0.8 part; The acid agent can be selected from one or more in citric acid, tartaric acid, malic acid, fumaric acid, anhydrous citric acid, the sodium dihydrogen citrate salt; Alkaline agent can be selected from one or more in potassium carbonate, potassium bicarbonate, sodium carbonate, sodium bicarbonate, calcium carbonate, the calcium bicarbonate; Binding agent is selected from the alcoholic solution of Polyethylene Glycol (PEG); Lubricant is selected from one or more in Polyethylene Glycol (PEG) 6000, Polyethylene Glycol (PEG) 4000, sodium lauryl sulphate, magnesium stearate, Pulvis Talci, the silicon dioxide.
Embodiment 2,
The multivitamin effervescent tablet of iron content zinc calcium; wherein: the composition of this effervescent tablet also comprises weight proportion: 0.004 part of vitamin A, 0.001 part of beta-carotene, 0.001 part in folic acid; 0.015 part of calcium pantothenate; 0.3 part of taurine, 0.005 part of vitamin B1,0.005 part of vitamin B2; 0.005 part of vitamin B6; 0.000015 part of vitamin B12,0.000005 part of vitamin D3,0.0375 part of vitamin E.
Embodiment 3,
The multivitamin effervescent tablet of iron content zinc calcium, wherein: this effervescent tablet is annular preparation.
Embodiment 4,
The multivitamin effervescent tablet of iron content zinc calcium, wherein: annular preparation comprises circular ring type, oval ring-like, polygon in ring-like any one.
Embodiment 5,
The multivitamin effervescent tablet of iron content zinc calcium, wherein: polygonly ring-likely be that triangle is ring-like, ring-like, the five side ring types in four directions, hexagon are ring-like, in ring-like any one of eight side ring types, odd plots of land that can be cultivated.
Embodiment 6,
The multivitamin effervescent tablet of iron content zinc calcium, wherein: the outer ring diameter of annulus is the 10-35 millimeter, interior ring diameter is the 2-8 millimeter.
Embodiment 7,
The multivitamin effervescent tablet of iron content zinc calcium, wherein: the outer ring diameter of annulus is the 12-18 millimeter, interior ring diameter is the 4-8 millimeter.
Embodiment 8,
The preparation method of the multivitamin effervescent tablet of iron content zinc calcium, concrete steps comprise: with the nutritional labeling mixing, get the A part; Alkaline agent, sweeting agent mixing add binding agent, cross 20 mesh sieves and granulate, and 45-50 ℃ is dried to moisture and is lower than 0.1%, and granulate is crossed the pharmacopeia sieve No. 2, the B part; 100 order pharmacopeia sieve was pulverized in the acid agent, granulated, and got the C part; C partly adds aromatic, sweeting agent, with A part, B part mixing, adding lubricant, mixing, tabletting in ring-like mould, promptly gets the effervescent tablet of annular preparation.
Embodiment 9,
Take by weighing nutritional labeling (weight portion) by following proportioning:
Ferrous sulfate 0.26 zinc sulfate 0.18 dalcium biphosphate 13
Vitamin A 0.004 beta-carotene 0.001 folic acid 0.001
Calcium pantothenate 0.015 taurine 0.3 vitamin B
10.005
Vitamin B
20.005 vitamin B
60.005 vitamin B
120.000015
Vitamin C 0.6 vitamin D
30.000005 vitamin E 0.0375
Take by weighing formula constituent (weight portion) by following proportioning
Anhydrous citric acid 105
Lactose 65 essence 3
Sodium bicarbonate 55 aspartames 5
PEG6000 5 mannitol 4
Silicon dioxide 3
Preparation method
With the nutritional labeling mixing, get the A part; Sodium bicarbonate, lactose, mannitol mixing add the PEG alcoholic solution and do binding agent, cross 20 mesh sieves and granulate, and 45-50 ℃ is dried to moisture and is lower than 0.1%, and granulate is crossed the pharmacopeia sieve No. 2, the B part; Anhydrous citric acid was pulverized 100 order pharmacopeia sieve, granulated with the PEG alcoholic solution, got the C part; C partly adds essence, aspartame, with A part, B part mixing, adds silicon dioxide, mixing, and tabletting, promptly.It is 20 millimeters that the solid tabletting of part obtains external diameter, and weight is the composite effervescent sheet of 4 gram/sheets.Another part is tabletting in ring-like mould, and promptly obtaining weight is the composite ring effervescent tablet of 4 gram/sheets, and its outer ring diameter is 28 millimeters, and interior ring diameter is 6 millimeters.
Embodiment 10,
Take by weighing nutritional labeling (weight portion) by following proportioning:
Ferrous sulfate 0.32 zinc sulfate 0.18 dalcium biphosphate 13
Vitamin A 0.004 beta-carotene 0.001 folic acid 0.001
Calcium pantothenate 0.015 taurine 0.28 vitamin B
10.005
Vitamin B
20.005 vitamin B
60.005 vitamin B
120.000015
Vitamin C 1.0 vitamin D
30.000005 vitamin E 0.0375
Take by weighing formula constituent (weight portion) by following proportioning
Tartaric acid 90
Lactose 75 essence 3
Potassium bicarbonate 60 cyclamates 5
PEG6000 5 mannitol 4
Silicon dioxide 3
Preparation method
With the nutritional labeling mixing, get the A part; Potassium bicarbonate, lactose, mannitol mixing add the PEG alcoholic solution and do binding agent, cross 20 mesh sieves and granulate, and 45-50 ℃ is dried to moisture and is lower than 0.1%, and granulate is crossed the pharmacopeia sieve No. 2, the B part; Tartaric acid was pulverized 100 order pharmacopeia sieve, granulated with the PEG alcoholic solution, got the C part; C partly adds essence, cyclamate, with A part, B part mixing, adds silicon dioxide, mixing, and tabletting, promptly.It is 25 millimeters that the solid tabletting of part obtains external diameter, and weight is the composite effervescent sheet of 5 gram/sheets.Another part is tabletting in ring-like mould, and promptly obtaining weight is the composite ring effervescent tablet of 5 gram/sheets, and its outer ring diameter is 35 millimeters, and interior ring diameter is 8 millimeters.Two kinds of effervescent tablets are put into 150 milliliters of (18 degrees centigrade) water to be observed:
Embodiment 11,
Take by weighing nutritional labeling (weight portion) by following proportioning:
Ferrous sulfate 0.26 zinc sulfate 0.26 dalcium biphosphate 13
Vitamin A 0.004 beta-carotene 0.001 folic acid 0.001
Calcium pantothenate 0.015 taurine 0.3 vitamin B
10.005
Vitamin B
20.005 vitamin B
60.005 vitamin B
120.000015
Vitamin C 1.0 vitamin D
30.000005 vitamin E 0.0375
Take by weighing formula constituent (weight portion) by following proportioning
Malic acid 95
Lactose 75 essence 4
Sodium bicarbonate 50 acesulfame potassiums 5
PEG6000 5 mannitol 6
Magnesium stearate 5
Preparation method
With the nutritional labeling mixing, get the A part; Sodium bicarbonate, lactose, mannitol mixing add the PEG alcoholic solution and do binding agent, cross 20 mesh sieves and granulate, and 45-50 ℃ is dried to moisture and is lower than 0.1%, and granulate is crossed the pharmacopeia sieve No. 2, the B part; Malic acid was pulverized 100 order pharmacopeia sieve, granulated with the PEG alcoholic solution, got the C part; C partly adds essence, acesulfame potassium, with A part, B part mixing, adds magnesium stearate, mixing, and tabletting, promptly.It is 8 millimeters that the solid tabletting of part obtains external diameter, and weight is the composite effervescent sheet of 3 gram/sheets.Another part is tabletting in ring-like mould, and promptly obtaining weight is the composite ring effervescent tablet of 3 gram/sheets, and its outer ring diameter is 10 millimeters, and interior ring diameter is 2 millimeters.Two kinds of effervescent tablets are put into 150 milliliters of (18 degrees centigrade) water to be observed:
Embodiment 12,
Take by weighing nutritional labeling (weight portion) by following proportioning:
Ferrous sulfate 0.26 zinc sulfate 0.26 dalcium biphosphate 13
Vitamin A 0.004 beta-carotene 0.001 folic acid 0.001
Calcium pantothenate 0.015 taurine 0.3 vitamin B
10.005
Vitamin B
20.005 vitamin B
60.005 vitamin B
120.000015
Vitamin C 1.0 vitamin D
30.000005 vitamin E 0.0375
Take by weighing formula constituent (weight portion) by following proportioning
Nutritional labeling 15 malic acids 95
Lactose 75 essence 4
Sodium bicarbonate 50 acesulfame potassiums 5
PEG6000 5 mannitol 6
Magnesium stearate 5
Preparation method
With the nutritional labeling mixing, get the A part; Sodium bicarbonate, lactose, mannitol mixing add the PEG alcoholic solution and do binding agent, cross 20 mesh sieves and granulate, and 45-50 ℃ is dried to moisture and is lower than 0.1%, and granulate is crossed the pharmacopeia sieve No. 2, the B part; Malic acid was pulverized 100 order pharmacopeia sieve, granulated with the PEG alcoholic solution, got the C part; C partly adds essence, acesulfame potassium, with A part, B part mixing, adds magnesium stearate, mixing, and tabletting, promptly.It is 8 millimeters that the solid tabletting of part obtains external diameter, and weight is the composite effervescent sheet of 3 gram/sheets.Another part is tabletting in ring-like mould, and promptly obtaining weight is the composite ring effervescent tablet of 3 gram/sheets, and its outer ring diameter is 10 millimeters, and interior ring diameter is 2 millimeters.Two kinds of effervescent tablets are put into 150 milliliters of (18 degrees centigrade) water to be observed:
Embodiment 13, one group of multivitamin effervescent tablet of iron content zinc calcium:
(1) the multivitamin effervescent tablet of iron content zinc calcium, wherein: the composition of this effervescent tablet comprises weight proportion: some parts of nutritional labeling, 50 parts of sour agent, 40 parts of alkaline agents, 1 part of binding agent, 1 part of lubricant, 1 part of sweeting agent aspartame; Wherein nutritional labeling comprises: 0.1 part in ferrous sulfate, 0.1 part in zinc sulfate, 8 parts of dalcium biphosphates, 0.2 part of vitamin C; The acid agent can be selected from 20 parts of fumaric acid, 30 parts of sodium dihydrogen citrate salt; Alkaline agent can be selected from 10 parts of potassium carbonate, 20 parts of sodium carbonate, 5 parts of sodium bicarbonate, 2 parts of calcium carbonate, 3 parts of calcium bicarbonate; Binding agent is selected from the alcoholic solution of Polyethylene Glycol (PEG); Lubricant is selected from Polyethylene Glycol (PEG) 4000.Make the effervescent tablet of annular preparation by the method for embodiment 8, obtaining weight is the composite ring effervescent tablet of 4 gram/sheets, and its outer ring diameter is 12 millimeters, and interior ring diameter is 4 millimeters.
(2) the multivitamin effervescent tablet of iron content zinc calcium, wherein: the composition of this effervescent tablet comprises weight proportion: some parts of nutritional labeling, 150 parts of sour agent, 120 parts of alkaline agents, 15 parts of binding agents, 5 parts of lubricants, 120 parts of sweeting agents, 5 parts of aromatic; Wherein nutritional labeling comprises: 0.4 part in ferrous sulfate, 0.4 part in zinc sulfate, 20 parts of dalcium biphosphates, 0.8 part of vitamin C; The acid agent can be selected from 60 parts of citric acids, 20 parts in tartaric acid, 70 parts of malic acids; Alkaline agent can be selected from 110 parts of sodium carbonate, 10 parts of sodium bicarbonate; Binding agent is selected from the alcoholic solution of Polyethylene Glycol (PEG); Lubricant is selected from 2 parts of sodium lauryl sulphates, 1 part in indurated talc powder, the silicon dioxide 2 parts.Sweeting agent is selected from 4 parts of cyclamates, 3 parts of steviosin, 2 parts of acesulfame potassiums, 1 part of aspartame, 30 parts of protein sugar, 55 parts of sucrose, 5 parts of saccharin sodium (calcium), 20 parts of lactose.Make the effervescent tablet of annular preparation by the method for embodiment 8, obtaining weight is the composite ring effervescent tablet of 3 gram/sheets, and its outer ring diameter is 18 millimeters, and interior ring diameter is 3 millimeters.Aromatic is selected from 3 parts of orange essences.2 parts in Herba Menthae essence.
(3) the multivitamin effervescent tablet of iron content zinc calcium, wherein: the composition of this effervescent tablet comprises weight proportion: some parts of nutritional labeling, 85 parts of sour agent, 65 parts of alkaline agents, 5 parts of binding agents, 2 parts of lubricants, 40 parts of sweeting agents, 2 parts of aromatic; Wherein nutritional labeling comprises: 0.3 part in ferrous sulfate, 0.25 part in zinc sulfate, 6 parts of dalcium biphosphates, 0.45 part of vitamin C; The acid agent can be selected from one or more in citric acid, tartaric acid, malic acid, fumaric acid, anhydrous citric acid, the sodium dihydrogen citrate salt;-alkaline agent can be selected from 35 parts of potassium carbonate, 20 parts of sodium carbonate, 10 parts of calcium bicarbonate; Binding agent is selected from the alcoholic solution of Polyethylene Glycol (PEG); Lubricant is selected from 1 part (PEG) 6000,1 parts of Pulvis Talci.Make the effervescent tablet of annular preparation by the method for embodiment 8, obtaining weight is the composite ring effervescent tablet of 2 gram/sheets, and its outer ring diameter is 11 millimeters, and interior ring diameter is 2 millimeters.Aromatic is selected from 2 parts of 2 parts of flavoring orange essences or 2 parts of Fructus Citri Limoniae essence or flavoring banana essences.
Claims (2)
1, the multivitamin effervescent tablet of a kind of iron content zinc calcium, the composition of this effervescent tablet comprise weight proportion: sour agent 50-150 part, alkaline agent 40-120 part, binding agent 1-15 part, lubricant 1-5 part, sweeting agent 1-120 part, aromatic 0-5 part; Ferrous sulfate 0.1-0.4 part, zinc sulfate 0.1-0.4 part, dalcium biphosphate 8-20 part, vitamin C 0.2-0.8 part; 0.004 part of vitamin A, 0.001 part of beta-carotene, 0.001 part in folic acid, 0.015 part of calcium pantothenate, 0.3 part of taurine, 0.005 part of vitamin B1,0.005 part of vitamin B2,0.005 part of vitamin B6,0.000015 part of vitamin B12,0.000005 part of vitamin D3,0.0375 part of vitamin E; The acid agent is one or more in citric acid, tartaric acid, malic acid, fumaric acid, anhydrous citric acid, the sodium dihydrogen citrate salt; Alkaline agent is one or more in potassium carbonate, potassium bicarbonate, sodium carbonate, sodium bicarbonate, calcium carbonate, the calcium bicarbonate; Binding agent is the alcoholic solution of Polyethylene Glycol (PEG); Lubricant is one or more in polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, magnesium stearate, Pulvis Talci, the silicon dioxide; It is characterized in that: this effervescent tablet is annular preparation.
2, the preparation method of the multivitamin effervescent tablet of claim 1 described iron content zinc calcium, concrete steps comprise: with the nutritional labeling mixing, get the A part; Alkaline agent, sweeting agent mixing add binding agent, cross 20 mesh sieves and granulate, and 45-50 ℃ is dried to moisture and is lower than 0.1%, and granulate is crossed the pharmacopeia sieve No. 2, the B part; 100 order pharmacopeia sieve was pulverized in the acid agent, granulated, and got the C part; C partly adds aromatic, with A part, B part mixing, adding lubricant, mixing, tabletting in ring-like mould, promptly gets the effervescent tablet of annular preparation.
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| CN107951034B (en) * | 2017-12-01 | 2021-03-23 | 郑州拓洋生物工程有限公司 | Effervescent vitamin preparation and its preparing process |
| CN108669403A (en) * | 2018-05-28 | 2018-10-19 | 广州富诺营养科技有限公司 | A kind of multivitamin effervescent tablet of iron content zinc calcium and its annular preparation and preparation method |
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