CN101836968B - Preparation method of effervescent pills - Google Patents
Preparation method of effervescent pills Download PDFInfo
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- CN101836968B CN101836968B CN2009100193997A CN200910019399A CN101836968B CN 101836968 B CN101836968 B CN 101836968B CN 2009100193997 A CN2009100193997 A CN 2009100193997A CN 200910019399 A CN200910019399 A CN 200910019399A CN 101836968 B CN101836968 B CN 101836968B
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- fine powder
- sodium bicarbonate
- effervescent
- tartaric acid
- principal agent
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Abstract
The invention discloses a preparation method of effervescent pills. The preparation method comprises the following steps: 1, respectively porphyrizing main drug, sodium bicarbonate and tartaric acid, and sieving the porphyrized materials through a sieve of 100 meshes; 2, adding PG400 (polyethylene glycol) into the main drug fine powder prepared in step 1, fully dissolving, adding molten PEG6000, and evenly stirring; 3, adding the sodium bicarbonate fine powder, heating to 65 DEG C, stirring so as to lead the sodium bicarbonate fine powder to be fully wrapped, adding the tartaric acid fine powder, evenly stirring, and placing into an insulated container; and 4, dropping the mixture prepared in step 3 into ice-bath paraffin oil to obtain the finished products. The invention combines the effervescence technology and the pill technology together, thus the prepared effervescent pills have the advantages of effervescence and pill preparations.
Description
Technical field
The present invention relates to a kind of new pharmaceutical dosage form.
Background technology
Effervescent tablet has easy to carry, and onset is characteristics rapidly.But also there is the shortcoming of the following aspects in existing effervescent tablet in actual production and use: 1, many substrate can not be dissolved in water fully, and medicinal liquid is muddy.Medicinal liquid like the chlorhexidine acetate effervescent tablet is just relatively more muddy, and influence is used; 2, must under dry environment, produce, many production environments are had relatively high expectations; 3, part substrate sticking; 4, some oxidisability medicine has corrosiveness to the tablet machine drift; 5, the bubble speckle appears in storage process easily.
Summary of the invention
The object of the invention provides a kind of new pharmaceutical dosage form with regard to being to be directed against the defective of above-mentioned prior art, and it has the advantage of effervescent and dropping pill formulation concurrently.
Its technical scheme is following:
A kind of method for preparing of newtype drug dosage form comprises the steps:
Step 1 is crossed 100 mesh sieves with principal agent, sodium bicarbonate, tartaric acid difference porphyrize;
Step 2 is got the principal agent fine powder that makes in the step 1, after adding PEG400 fully dissolves, adds fused PEG6000 and stirs;
Step 3 adds sodium bicarbonate fine powder and is heated to 65 degrees centigrade, stirs, and makes sodium bicarbonate fine powder by abundant parcel, adds the tartaric acid fine powder again and stirs, and inserts in the cool-bag;
The mixture that step 4 makes step 3 splashes in the ice-bath paraffin oil, gets product.
Above-mentioned principal agent can be chlorhexidine acetate, povidone iodine, vitamin C etc.
The present invention combines the effervescent technology with the drop pill technology, have the advantage of effervescent and dropping pill formulation concurrently.Its beneficial effect is mainly reflected in the following aspects:
1, the above-mentioned effervescent pills preparation that is made by the present invention can dissolve by rapid effervescent in water, and obtain clarifying drug solution.Compare with effervescent tablet, the used substrate of the present invention all is water-soluble substances, thereby the clarification of gained medicinal liquid.
2, principal agent can fully disperse in drop pill substrate, forms solid dispersion.Compare with effervescent tablet, under the same stored condition, the effervescent pills surface is not easy to produce the bubble speckle.
3, this preparation is processed with dropping preparation method, compares with effervescent tablet, does not require harsh dry environment, does not also have sticking problem common when preparing effervescent tablet.
The specific embodiment
List the dosage form of several kinds of different principal agents below with the form of tabulation.
| Principal agent | Sodium bicarbonate | Tartaric acid | PEG400 | PEG6000 | |
| Chlorhexidine acetate | 5 | 14 | 8 | 30.5 | 42.5 |
| Povidone iodine | 6 | 12 | 6 | 1 | 75 |
| Vitamin C | 10 | 12 | 2 | 20 | 56 |
Above-mentioned each embodiment all adopts following method preparation, comprises the steps:
Step 1 is processed principal agent, sodium bicarbonate, tartaric acid difference porphyrize fine powder and is sieved;
Step 2 is got the principal agent fine powder that makes in the step 1, after adding PEG400 fully dissolves, adds fused PEG6000 and stirs;
Step 3 adding sodium bicarbonate fine powder is heated to 65 degrees centigrade, and (PEG6000 still is molten condition in the time of 65 degrees centigrade; Temperature is crossed to hang down and is prone to cause PEG to solidify; Too highly then be prone to cause principal agent and sodium bicarbonate to decompose) stir; Make sodium bicarbonate fine powder by abundant parcel, add the tartaric acid fine powder again and stir, insert in the cool-bag;
The mixture that step 4 makes step 3 splashes in the ice-bath paraffin oil, gets product.
The made preparation of the present invention requires to be stored in hermetic container, and ambient temperature is not higher than 37 degrees centigrade.
Can find out that by table 1 the present invention is superior to effervescent tablet in appearance, show as effervescent pills and in storage period, do not bubble, and effervescent tablet just begin to bubble in the time of 2 months.We think that this and gas-producing disintegrant sodium bicarbonate and tartaric acid dissolve and fully disperse relevant in drop pill excipient PEG.
The outward appearance contrast of table 1 effervescent pills and effervescent tablet
The stable results of comparison of table 2 shows that stability of the present invention will be higher than effervescent tablet.This is because principal agent among the present invention and adjuvant all are that the dissolving back disperses with molecularity in excipient such as PEG, and this homogeneous that helps each composition in the preparation is with stable.
The stability contrast (n=5) of table 2 effervescent pills and effervescent tablet
Stipulate to measure dissolve scattered time limit down according to 2005 editions appendix disintegration of tablet time limit items of Chinese Pharmacopoeia.Dissolve scattered time limit has been checked povidone iodine effervescent pills, effervescent tablet, and the dissolve scattered time limit of chlorhexidine acetate effervescent pills, effervescent tablet all meets the requirement of effervescent tablet within 1 ~ 6 month.Table 3 has been listed the dissolve scattered time limit of chlorhexidine acetate effervescent pills and chlorhexidine acetate drop pill.
The dissolve scattered time limit of table 3 chlorhexidine acetate effervescent pills and hibitane drop pill
Table 3 is the result show, the dissolve scattered time limit of hibitane effervescent pills and hibitane drop pill is all up to specification, and the hibitane effervescent pills is much smaller than the dissolve scattered time limit of hibitane the ten thousandth, and promptly hibitane effervescent pills dissolution velocity is quite fast.
The present invention includes but be not limited in above embodiment, the principal agent that it also can select for use other characteristics and above-mentioned adjuvant to adapt, the proportion relation of its each component also can carry out necessary adjustment as required.
Claims (2)
1. the method for preparing of effervescent pills comprises the steps:
Step 1 is crossed 100 mesh sieves with principal agent, sodium bicarbonate, tartaric acid difference porphyrize;
Step 2 is got the principal agent fine powder that makes in the step 1, after adding PEG400 fully dissolves, adds fused PEG6000 and stirs;
Step 3 adds sodium bicarbonate fine powder and is heated to 65 degrees centigrade of stirrings, makes sodium bicarbonate fine powder by abundant parcel, adds the tartaric acid fine powder again and stirs, and inserts in the cool-bag;
The mixture that step 4 makes step 3 splashes in the ice-bath paraffin oil, gets product;
Said principal agent is a chlorhexidine acetate, and its each ingredients weight parts proportioning is following:
2. the method for preparing of effervescent pills comprises the steps:
Step 1 is crossed 100 mesh sieves with principal agent, sodium bicarbonate, tartaric acid difference porphyrize;
Step 2 is got the principal agent fine powder that makes in the step 1, after adding PEG400 fully dissolves, adds fused PEG6000 and stirs;
Step 3 adds sodium bicarbonate fine powder and is heated to 65 degrees centigrade of stirrings, makes sodium bicarbonate fine powder by abundant parcel, adds the tartaric acid fine powder again and stirs, and inserts in the cool-bag;
The mixture that step 4 makes step 3 splashes in the ice-bath paraffin oil, gets product;
Said principal agent is a povidone iodine, and its each ingredients weight parts proportioning is following:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100193997A CN101836968B (en) | 2009-10-23 | 2009-10-23 | Preparation method of effervescent pills |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100193997A CN101836968B (en) | 2009-10-23 | 2009-10-23 | Preparation method of effervescent pills |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101836968A CN101836968A (en) | 2010-09-22 |
| CN101836968B true CN101836968B (en) | 2012-08-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100193997A Expired - Fee Related CN101836968B (en) | 2009-10-23 | 2009-10-23 | Preparation method of effervescent pills |
Country Status (1)
| Country | Link |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107753459A (en) * | 2017-10-26 | 2018-03-06 | 安徽世龙生物医药科技有限公司 | A kind of vitamin C effervescent tablet and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1345554A (en) * | 2000-09-26 | 2002-04-24 | 江苏板桥药业有限责任公司 | Gingkgo vitamin C effervescent tablets |
| CN1729994A (en) * | 2005-07-25 | 2006-02-08 | 华中农业大学 | Povidone iodine effervescence tablet for treating milk cow colpitis, its preparation process and application |
| CN1759825A (en) * | 2004-10-11 | 2006-04-19 | 江西本草天工科技有限责任公司 | Effervescence tablet containing multiplex vitamin including iron, zinc and calcium, ring shaped preparation, and preparation method |
-
2009
- 2009-10-23 CN CN2009100193997A patent/CN101836968B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1345554A (en) * | 2000-09-26 | 2002-04-24 | 江苏板桥药业有限责任公司 | Gingkgo vitamin C effervescent tablets |
| CN1759825A (en) * | 2004-10-11 | 2006-04-19 | 江西本草天工科技有限责任公司 | Effervescence tablet containing multiplex vitamin including iron, zinc and calcium, ring shaped preparation, and preparation method |
| CN1729994A (en) * | 2005-07-25 | 2006-02-08 | 华中农业大学 | Povidone iodine effervescence tablet for treating milk cow colpitis, its preparation process and application |
Non-Patent Citations (1)
| Title |
|---|
| 刘人树等.小儿平喘泡腾片的制备方法.《中南药学》.2008,第6卷(第3期),315-317. * |
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| CN101836968A (en) | 2010-09-22 |
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Owner name: NO.88 HOSPITAL, P.L.A. Free format text: FORMER OWNER: LIU WEI Effective date: 20101217 Free format text: FORMER OWNER: ZHANG ZHAOQIN ZHANG QIANG SUN XIN YU HUIQIN |
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Inventor after: Liu Wei Inventor after: Zhang Qiang Inventor after: Zhang Zhaoqin Inventor after: Sun Cuan Inventor after: Yu Huiqin Inventor before: Liu Wei Inventor before: Zhang Qiang |
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Free format text: CORRECT: ADDRESS; FROM: 271000 502, BUILDING 3, DORMITORY 3, HOSPITAL 88, HUSHAN EAST ROAD, TAISHANDISTRICT, TAIAN CITY, SHANDONG PROVINCE TO: 271000 NO. 6, DONGCUN VILLAGE, HONGMEN ROAD, TAISHAN DISTRICT, TAI AN CITY, SHANDONG PROVINCE Free format text: CORRECT: INVENTOR; FROM: LIU WEI ZHANG QIANG TO: LIU WEI ZHANG QIANG ZHANG ZHAOQIN SUN XIN YU HUIQIN |
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Effective date of registration: 20101217 Address after: Red Gate Road Taishan District 271000 village in Shandong province Tai'an City No. 6 Applicant after: No.88 Hospital, P. L. A. Address before: Three, building 3, building 88, 502 hospital, Hushan East Road, Taishan District, Shandong, Tai'an 271000 Applicant before: Liu Wei Co-applicant before: Zhang Zhaoqin Co-applicant before: Zhang Qiang Co-applicant before: Sun Cuan Co-applicant before: Yu Huiqin |
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